#=GF ID   DUF6374
#=GF AC   PF19901.5
#=GF DE   Family of unknown function (DUF6374)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   25.10 25.60;
#=GF NC   24.70 22.20;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 8 -Z 90746521 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   30867595
#=GF RT   Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of
#=GF RT   natural products.
#=GF RA   Zhang B, Wang KB, Wang W, Wang X, Liu F, Zhu J, Shi J, Li LY,
#=GF RA   Han H, Xu K, Qiao HY, Zhang X, Jiao RH, Houk KN, Liang Y, Tan
#=GF RA   RX, Ge HM;
#=GF RL   Nature. 2019;568:122-126.
#=GF DR   INTERPRO; IPR045954;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0002024) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, polyketide, in particular
#=GF CC   the nargenicin biosynthetic gene cluster from Nocardia
#=GF CC   argentinensis [1].
#=GF SQ   28
#=GS A0A7X6L344_9NOCA/1-59   AC A0A7X6L344.1
#=GS A0A370I526_9NOCA/10-68  AC A0A370I526.1
#=GS A0A164K7S5_9NOCA/1-48   AC A0A164K7S5.1
#=GS A0A7K0DU52_9NOCA/1-59   AC A0A7K0DU52.1
#=GS A0A370GJG3_9NOCA/1-59   AC A0A370GJG3.1
#=GS A0A846XQ89_9NOCA/1-59   AC A0A846XQ89.1
#=GS A0A7W9PDD3_9NOCA/1-59   AC A0A7W9PDD3.1
#=GS A0A7G1KBA2_9NOCA/1-59   AC A0A7G1KBA2.1
#=GS A0A231HF88_9NOCA/1-58   AC A0A231HF88.1
#=GS A0A6G9YBB3_9NOCA/1-54   AC A0A6G9YBB3.1
#=GS A0A4R6NWN1_NOCIG/1-43   AC A0A4R6NWN1.1
#=GS A0A931N361_9NOCA/1-58   AC A0A931N361.1
#=GS A0A231GUH8_9NOCA/1-58   AC A0A231GUH8.1
#=GS A0A1V2TGH7_9NOCA/25-83  AC A0A1V2TGH7.1
#=GS U5EAF6_NOCAS/1-59       AC U5EAF6.1
#=GS A0A378YFJ9_9NOCA/1-59   AC A0A378YFJ9.1
#=GS A0A379JNB9_9NOCA/1-57   AC A0A379JNB9.1
#=GS A0A7K0DNB7_9NOCA/1-59   AC A0A7K0DNB7.1
#=GS A0A6I3L6N7_9NOCA/1-58   AC A0A6I3L6N7.1
#=GS A0A917RH61_9NOCA/1-59   AC A0A917RH61.1
#=GS A0A4V3CME4_NOCIG/1-54   AC A0A4V3CME4.1
#=GS A0A7D6VN18_9NOCA/1-56   AC A0A7D6VN18.1
#=GS A0A3M2LA57_9NOCA/2-60   AC A0A3M2LA57.1
#=GS A0A164HE06_9NOCA/1-59   AC A0A164HE06.1
#=GS A0A6I2FW31_9NOCA/1-58   AC A0A6I2FW31.1
#=GS K0F577_NOCB7/1-59       AC K0F577.1
#=GS A0A849CBQ1_9NOCA/1-60   AC A0A849CBQ1.1
#=GS A0A7K0CWG6_9NOCA/10-67  AC A0A7K0CWG6.1
A0A7X6L344_9NOCA/1-59              ..MPDLEPTQFAYSQINAVRRQLLDAAAFGKHLRPEHLENMAGKLAEGLRAYTEAMTPT--tp....
A0A370I526_9NOCA/10-68             ..MPPDRHIQFAQLWLEQVRDRLASAAATSDPLGPEQLNILSGKVAEGLRIFTELTEHHR-s.....
A0A164K7S5_9NOCA/1-48              ..-----------MNLEQVRSQLLDAAAFGKYLPPEQLENAAGKIAEGLRIFLEETQHL--aq....
A0A7K0DU52_9NOCA/1-59              ..MSEPARIPDAYQQIDQVRRQLVEAAAFSKHLTPDALEHLAGTLATGLRLIADHTTA---spv...
A0A370GJG3_9NOCA/1-59              ..MPLDRHIHLAQLWLEQVRDHLASSAATSTNLSAEQLNVMSGKVAEGLRIFTELAGQPS-t.....
A0A846XQ89_9NOCA/1-59              ..MPELAPIPFARLNLEQVRERLLAAAAFGESLSPDQLEALAGKLSAGLNIYIEATQNSS-r.....
A0A7W9PDD3_9NOCA/1-59              ..MPLDRHIHFAQLWLEQVRDHLASAAATSTNLSAEQLNVMSGKVAEGLRIFTELADQPP-a.....
A0A7G1KBA2_9NOCA/1-59              ..MPLDRHIQFAQLWLEQVRDHLASAAATSSPLTAEQLSVMSGKVTEGLRVFTELAAT---ttn...
A0A231HF88_9NOCA/1-58              me---LTPLEYARLNLEQVRAQLVDAAAFDKALTPDQLERAAWKIREGLRIYREHTESP--rv....
A0A6G9YBB3_9NOCA/1-54              ..MLERSRISLAQTQIDNVRRQLLDAAAFGKRITPDQLEHLAAKLGDSLRILTEE------p.....
A0A4R6NWN1_NOCIG/1-43              ..MAQTSRPDWTAAALTALRRQVLDATAFGVLVHPTQVY----------------------aitacl
A0A931N361_9NOCA/1-58              ..MSDPDRIDFARAQVEDVRRALLDAAAFGKTLRPAPLEGLAGKLAAALRIYREVGE----qge...
A0A231GUH8_9NOCA/1-58              md---LSRLEWARMNLEQVRAQLLDAAAFAKYLPPEQLERAAWKIGEGLRIYREETEPA--da....
A0A1V2TGH7_9NOCA/25-83             ..MPELAPIPFARMNLEQVRERLLAAAAFGETLSPDQLEALARKVTAGLRIYIQATQNGA-r.....
U5EAF6_NOCAS/1-59                  ..MSEMPAPAPTAAALATVRRQLGVCAAFGAVAAPEQLDEIAERLTEVLRGYAVADTRRY-p.....
A0A378YFJ9_9NOCA/1-59              ..MPELSRLDWARMNLDQVRRQLLDAAAFGKYITPEQLEHAAGKIAEGMRIYLEETHPTP-a.....
A0A379JNB9_9NOCA/1-57              ..MPELDRRDWAALNLRQVCAQLLDAAAFGKYLTPEQLEHAAGKVGEGLRVFLEETER---s.....
A0A7K0DNB7_9NOCA/1-59              ..MPLDRHLQFAQLWLEQVRDNLATAAATGTPVPPEQLNIMSGKIAAGLRVFSELAEHRP-h.....
A0A6I3L6N7_9NOCA/1-58              ..MPELSRRDWATMNLKEVQRQLLKAASFGKALSPEQLENAAGKIGEGLRIFLEEMDQ---tg....
A0A917RH61_9NOCA/1-59              ..MPELAPIPFARLNLEQVRERLLAAAAFGEDLSPDQLEVLAGKLSTGLSIYIEATQNSA-p.....
A0A4V3CME4_NOCIG/1-54              ..MAQTSRPDWTAAALAALRRQVLDATAFGAVVHPAQVEAITARLDAHLR-----------arlrhd
A0A7D6VN18_9NOCA/1-56              ..MPELSRLEWAHMNLDQVRRQLLDAAAWGKYITPEQLEHAAGKIAEGMRIYREE------ige...
A0A3M2LA57_9NOCA/2-60              ..SPAERRIRFAQQWLEQVRDHLADAGAQGSPLSPEQLNILSGKVAGGLEIFVAETRAVS-h.....
A0A164HE06_9NOCA/1-59              ..MPLERHVQFAQLWLEQVRDRLAEAGATSASLPPEQLNILSGKVAEGLRIFIEATHEPP-a.....
A0A6I2FW31_9NOCA/1-58              ..MPELSRHEWATMNLEQVRRQLLDAAAFGKYMTPEQLENAAGKIGEGLRIFREETDHP--r.....
K0F577_NOCB7/1-59                  ..MSQPSRREWATWNLEQVRDQLLDAAACGKRLPPEQLEQAAGKIGEGLRVFQELTRGAA-e.....
A0A849CBQ1_9NOCA/1-60              ..MPDLDPVAIAHMQLNDVRRQLLDAAAFGKLTPPEWLEHMAGRVADGLRIYTAAL-----dsrtpe
A0A7K0CWG6_9NOCA/10-67             ..MPLDRH-HLAHLWLEQVRDHLAQAATTNTPLPPEQLNIMSGKVAAGLQILTEPTHPD--eh....
#=GC seq_cons                      ..MPp.s+lpaAphpLEQVRcpLL-AAAFGchLsPEQLEthAGKlu-GLRIatEtspt...s.....
//