#=GF ID   DUF7497
#=GF AC   PF24327.3
#=GF DE   Domain of unknown function (DUF7497)
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Andreeva A;0000-0002-0450-0091
#=GF SE   ECOD:Q4CU84_D5
#=GF GA   27.80 27.80;
#=GF TC   27.80 37.20;
#=GF NC   27.50 26.80;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0159
#=GF DR   INTERPRO; IPR055920;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in a group of uncharacterised eukaryotic
#=GF CC   proteins. It contains two highly conserved cysteines. This
#=GF CC   domain is predicted to fold into Ig-like beta-sandwich.
#=GF SQ   32
#=GS A0A7G2CM12_9TRYP/392-497    AC A0A7G2CM12.1
#=GS A4HLG9_LEIBR/162-264        AC A4HLG9.2
#=GS A0A7G2CSA7_9TRYP/129-243    AC A0A7G2CSA7.1
#=GS A0A422MWD3_TRYRA/1255-1354  AC A0A422MWD3.1
#=GS A0A3R7MAE0_9TRYP/1267-1366  AC A0A3R7MAE0.1
#=GS K2MU84_TRYCR/259-358        AC K2MU84.1
#=GS A0A7G2CM12_9TRYP/134-250    AC A0A7G2CM12.1
#=GS A0A7G2CMA5_9TRYP/32-133     AC A0A7G2CMA5.1
#=GS A4HLG8_LEIBR/72-151         AC A4HLG8.1
#=GS A0A7G2CMA5_9TRYP/245-341    AC A0A7G2CMA5.1
#=GS A0A7G2CSA7_9TRYP/590-691    AC A0A7G2CSA7.1
#=GS A0A1X0NQV5_9TRYP/2889-2988  AC A0A1X0NQV5.1
#=GS S9UXK6_9TRYP/332-432        AC S9UXK6.1
#=GS Q4Q476_LEIMA/124-226        AC Q4Q476.1
#=GS A0A0N0DSY8_LEPPY/142-244    AC A0A0N0DSY8.1
#=GS A4I8X9_LEIIN/124-226        AC A4I8X9.1
#=GS A0A061J3P1_TRYRA/586-685    AC A0A061J3P1.1
#=GS A0A7G2CSA7_9TRYP/1029-1125  AC A0A7G2CSA7.1
#=GS A0A0M9FVC6_LEPPY/142-244    AC A0A0M9FVC6.1
#=GS A0A7G2CSA7_9TRYP/811-912    AC A0A7G2CSA7.1
#=GS A0A0M9FV86_LEPPY/145-247    AC A0A0M9FV86.1
#=GS A0A1X0P0N0_9TRYP/1240-1339  AC A0A1X0P0N0.1
#=GS A0A7G2CM12_9TRYP/886-974    AC A0A7G2CM12.1
#=GS A0A7G2CSA7_9TRYP/369-470    AC A0A7G2CSA7.1
#=GS Q4CRJ6_TRYCC/83-182         AC Q4CRJ6.1
#=GS A0A0S4JA94_BODSA/3066-3165  AC A0A0S4JA94.1
#=GS A0A1X0P224_9TRYP/1240-1339  AC A0A1X0P224.1
#=GS Q389M5_TRYB2/1242-1341      AC Q389M5.1
#=GS A0A7G2CM12_9TRYP/647-747    AC A0A7G2CM12.1
#=GS Q4CU84_TRYCC/471-570        AC Q4CU84.1
#=GS S9UXK6_9TRYP/79-195         AC S9UXK6.1
#=GS Q4DZQ8_TRYCC/1253-1352      AC Q4DZQ8.1
A0A7G2CM12_9TRYP/392-497               aklhvsghn------STYPT.IVKSGETLLILGTFDENAV..YEVLMYYSKQDi.....aDISATVPTCT.........SLQITS...........NRIECTI.FSKPSI..MGPFKFLVRDVATGWILP...GSTSLTDILISS-s..........
A4HLG9_LEIBR/162-264                   .......sp--HKVTGESSS.WPSTGETWTISGTFDPAKS..YSVVFYNTEADa.....vPGNPSPVTCA.........ALSVAA...........TKLSCTI.IAVNGV..MGMYRFLVKDTTSDALLL...GSTSLSSIAVNPP...........
A0A7G2CSA7_9TRYP/129-243               ........p-EELVTSFSTD.ALTVGKDWVLYGNFDLSAE..YEILFYNNQKMm.....vDGSPGLPACT.........AVTVGRgmsqegapspaNALTCKAvTSHVGS..MGMYSVLVRNKGNGQFVR...GSTTLWMVTVE--fd.........
A0A422MWD3_TRYRA/1255-1354             .......sg--ESVGAVRPH.SVQNGDILELFGLFITSSR..YSVRFVRAAST.......GGSHVAPLCT.........VDGVQA...........GSLMCKM.QVRAGV..IGMWNVSLMNGATQVPFA...-KGTRNEIQVLP-l..........
A0A3R7MAE0_9TRYP/1267-1366             ........t-EESVGAVRPS.RVHDGDVLEMFGAFITSSR..YSVRFVPAVPG.......SGIRVAPLCA.........VDKVTT...........STLSCKM.QVRAGT..IGRWNVSLMKGTTQVPFV...-EGARSEILALP-l..........
K2MU84_TRYCR/259-358                   ........a-KATVGAIRPL.SVRNGDDLEMFGTFITGSS..YILRFYPAVSG.......GDTMAAPTCA.........VHKVTT...........GVLTCEM.QVQAGT..VGGWNVSLLDGEAPVPFE...-EGAVNTIHVLPP...........
A0A7G2CM12_9TRYP/134-250               ........p-NSRIVSTADG.PFTVGKKLTIYGTFEDNTE..YEVLLYNEQEKlaqenieDGSQFFATCEnaavdhvniV----Stv.......vpNAITCTL.SKRPMA..MGRYGVIVRNKATLAIMR...GSGALEGFDIQN-t..........
A0A7G2CMA5_9TRYP/32-133                ...qnfsvv---------GI.TPSSGTEFTIYGVFNTSAT..YAVQFYNVQDGm.....vSGSPGLPTCS.........SLKISAd.........gTTLSCTA.EIKIGM..IGMYGFLVRDSDTHWYLN...GSTSLSPIAIIPP...........
A4HLG8_LEIBR/72-151                    .......ln-----------.--------------DPAKS..YSVVFYNTEADa.....vPGNPSPVTCA.........ALSVAA...........TKLTCTI.IAVNGV..MGMYRFLVKDTTSDALLL...GSTSLSSIAVNPP...........
A0A7G2CMA5_9TRYP/245-341               .......yl--NNYSAIVPT.TVRDGEKLHFIGNFSESLQ..YTVEL------.......--GENAPTCA........dAKLISQ...........NILQCTY.KGKVGY..TSSIEPLVRESSSQAYVSyntTTISLTSLTVYPP...........
A0A7G2CSA7_9TRYP/590-691               ........a-EYAVSSIQND.QPNTGDSFVIYGIFDASQT..YTVQFYNLQSPm.....vDGSPGLPTCT.........GVVATS...........SSLTCTV.KSEIGM..MGMYRFLVTDS-TGWILP...GSTTVNAIAINPT...........
A0A1X0NQV5_9TRYP/2889-2988             ........t-NDTVWFITPN.EPSDGEDIYFGGYFSSTSSedYNVLIEPIRS-.......NNTVRSPTCR.........VKQVNQ...........TMLVCTI.SVPVGT..IGLWNTSIYKTGVKVTYE...--GVLNVLVCVPP...........
S9UXK6_9TRYP/332-432                   ........s-SSYVADGAPL.AVSSGSELTLYGAYADTTAanYEVRFVNGGTG.......ALASGAGTCA.........VVSVSS...........TALRCTYtAAGSSA..SSAVAPMVYTTAGAAYLQ...T------------gllldstya..
Q4Q476_LEIMA/124-226                   ........a-PHKVTGQSSD.WPSTGDAWSISGTFDPANH..YSVLFYNIEAEa.....aAGNPSQITCA.........LLTVTA...........SKLTCTI.VAANGV..MGMYRFLVKDTTKGTLLL...GSTSLGAIAVNPP...........
A0A0N0DSY8_LEPPY/142-244               ........s-NYRVTGQSSD.WPSTGDTWSVSGTFNPAST..YSIVFYNNQKKa.....aIDSPGTPTCA.........PVKVTA...........TTLTCTI.TSANGV..MGMYNFLVRDSTNNALLL...GSSSLPMLAVNPP...........
A4I8X9_LEIIN/124-226                   .......gp--HKVTGQSSD.WPSTGDAWSISGTFDPANH..YSVLFYNIEAEa.....aAGNPSHVTCA.........LLTVTA...........SKLTCTI.IAASGV..MGMYRFLVKDTTKGTLLL...GSTSLGAIAVNPP...........
A0A061J3P1_TRYRA/586-685               .......sg--ESVGAVRPH.SVQNGDILELFGVFVASSR..YSVRFVPAASA.......GGSHVAPLCT.........IDGVRT...........GSLMCKM.QVRAGA..IGMWNVSLMNGATQVPFA...-KGTRNEIQVIP-r..........
A0A7G2CSA7_9TRYP/1029-1125             .......yl--YNYTAVAPT.AVQDGNTITFFGHFDPAGR..YVVSF------.......--GTSDVTCD........sPVVVSK...........TVLQCTY.KAPVGF..TGDTFPYVRDEANGAYLShdaTAITAATLTLYPP...........
A0A0M9FVC6_LEPPY/142-244               ........s-NYRVTGQSSD.WPSTGDTWSVSGTFNPAST..YSIVFYNNQKKa.....aIDSPGTPTCA.........PVKVTA...........TTLTCTI.TSANGV..MGMYNFLVRDSTNNALLL...GSSSLPMLAVNPP...........
A0A7G2CSA7_9TRYP/811-912               ........a-EYAVSSIQND.QPNTGDSFVIYGIFDASQT..YTVQFYNLQSPm.....vDGSPGLPTCT.........GVVATS...........SSLTCTV.KSEIGM..MGMYRFLVTDS-TGWILP...GSTTVNAIAINPT...........
A0A0M9FV86_LEPPY/145-247               ........s-NYRVTGQSSD.WPSTGDTWSVSGTFNPAST..YSIVFYNNQKKa.....aIDSPGTPTCA.........PVKVTA...........TTLTCTI.TSANGV..MGMYNFLVRDSTNNALLL...GSSSLPMLAVNPP...........
A0A1X0P0N0_9TRYP/1240-1339             ........t-TESVTAVQPS.TVSNGTILELHGKFNNNTQ..YSVVFTPATSA.......AGKMIIPLCT.........IQKVMP...........AVLTCEM.SVRAGV..MGNWNVSLTDGHEPLPFE...-DDVVRTLRVQPP...........
A0A7G2CM12_9TRYP/886-974               .......ym--YNVTMAAPS.NLRDNSYLTFFGHFNASAT..YNVTF------.......-GKSYAMTCD.........VVSVST...........NAVRCLY.NSNGQAvdSGDAFPLLNDAET-----...-------------tgrltrdartl
A0A7G2CSA7_9TRYP/369-470               ........a-EYAVSSIQND.QPNTGDSFVIYGIFDASQT..YTVQFYNLQSPm.....vDGSPGLPTCT.........GVVATS...........SSLTCTV.KSEIGM..MGMYRFLVTDS-TGWILP...GSTTVNAIAINPT...........
Q4CRJ6_TRYCC/83-182                    ........a-KATVRAIRPF.SVRNGDDLEMFGTFIPDSS..YIVRFNPAVSG.......GDKMAAPTCA.........VQKVTT...........GVLTCEM.QVQAGT..VGGWNVSLLDGEAPVPFE...-EGAVNTIHVLPP...........
A0A0S4JA94_BODSA/3066-3165             .......aa--GYVSSVSPM.IVADDGVLTLSGNYSNNVTtaYTVQLVGASAQ.......PTTMKIPTCS.........ITFVNA...........SVVLCSM.SVRQNT..SGQWLVNLYFRGEQVT--...-NKQVFSITAVPP...........
A0A1X0P224_9TRYP/1240-1339             ........t-TESVTAVQPS.TVSNGTILELHGKFNINTQ..YSVVFTPVTSA.......AGKMIIPLCT.........IQKVMP...........AVLTCEM.SVRAGV..MGNWNVSLTDGQEPLPFE...-DDVVRTLRVHPP...........
Q389M5_TRYB2/1242-1341                 ........a-DDIVAAIRPR.MVRDGVVAQFYGRFDPRKG..YAVNFTSSGTP.......RPDCTKPFCS.........VLSITE...........ELLTCEV.HVNTPL..ACNWTAVVSSGGKAVPFS...-SGSFTTLQVHPS...........
A0A7G2CM12_9TRYP/647-747               ......etl---YVSSRGGGsVLAFEEVMEIFGRFDATAT..YEVIVYNSEE-.......GGSDDGPTCT.........VVTVNS...........NKVTCSL.WKKPSH..MGLFKILVRDKKSGWILR...ISPNVRPFLLNS-r..........
Q4CU84_TRYCC/471-570                   ........a-KATVGAIRPF.SVRNGDDLEMFGTFIPDSS..YIVRFNPAVSG.......GDKMAAPTCA.........VQKVTT...........GVLTCEM.QVQAGT..VGGWNVSLLDGEAPVPFE...-EGAVNTIHVLPP...........
S9UXK6_9TRYP/79-195                    ........v-SEVVTGIAGDgTITTGDSFTLYGNFSEGST..YKLLLYNAQSAm.....vTGSPGLPACSn......adALTVKRtgrg..taplpNTLVCTSlTTVTQA..MGMYGYLVYNTGTNRYVY...GSATLYLLAVNPP...........
Q4DZQ8_TRYCC/1253-1352                 ........a-KATVGAIRPF.SVRNGDDLEMFGTFITDSS..YIVRFNPAVSG.......GDTMAAPTCA.........VQKVTT...........GVLTCEM.QVQAGT..VGGWNVSLLDGEAPVPFE...-EGAVNTIHVLPP...........
#=GC seq_cons                          ........s..tpVsuhpss.tspsG-shplaGsFssuss..YsVhFhsspst.......ssssshPTCs.........shpVos...........ssLoCoh.pspsGs..hGhaphhVpDssssshh.....ssslssltl.Ps...........
//