#=GF ID   DUF8596
#=GF AC   PF29882.1
#=GF DE   Domain of unknown function (DUF8596)
#=GF AU   Pfeiffer F;0000-0003-4691-3246
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   Friedhelm Pfeiffer
#=GF GA   31.50 31.50;
#=GF TC   31.60 31.50;
#=GF NC   31.30 31.40;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Domain_of_unknown_function
#=GF CL   CL0328
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a domain of unknown function found in a group of
#=GF CC   uncharacterised archaeal proteins, including HVO_1906
#=GF CC   (Swiss:D4GTD9) from Haloferax volcanii. It has several conserved
#=GF CC   residues R, W and H.
#=GF SQ   41
#=GS A0A0U5H5F1_9EURY/4-143   AC A0A0U5H5F1.1
#=GS A0A4T0V026_9ACTN/5-145   AC A0A4T0V026.1
#=GS A0A3N0GTH2_9ACTN/14-154  AC A0A3N0GTH2.1
#=GS A0A975T079_9ACTN/6-146   AC A0A975T079.1
#=GS A0A930VF35_9ACTN/4-143   AC A0A930VF35.1
#=GS A0A6B9F116_9EURY/4-143   AC A0A6B9F116.1
#=GS A0A1I0V6V1_9BACL/9-148   AC A0A1I0V6V1.1
#=GS D4GTD9_HALVD/65-209      AC D4GTD9.1
#=GS A0A3A6PSJ4_9EURY/4-143   AC A0A3A6PSJ4.1
#=GS E1ICQ4_9CHLR/98-239      AC E1ICQ4.1
#=GS A0A4R5BVH5_9ACTN/81-222  AC A0A4R5BVH5.1
#=GS A0A1H3E917_9EURY/4-143   AC A0A1H3E917.1
#=GS A0A418Q5J8_9CORY/6-152   AC A0A418Q5J8.1
#=GS A0A417Y4S2_9ACTN/5-145   AC A0A417Y4S2.1
#=GS A0A830EJ65_9EURY/4-143   AC A0A830EJ65.1
#=GS A0A0T2IHG9_9MICO/5-144   AC A0A0T2IHG9.1
#=GS A0A7M2YUX8_9ACTN/6-145   AC A0A7M2YUX8.1
#=GS M1XPV6_NATM8/4-143       AC M1XPV6.1
#=GS A0A1S8ART1_9EURY/3-142   AC A0A1S8ART1.1
#=GS A0A1V1VYZ4_9ACTN/6-147   AC A0A1V1VYZ4.1
#=GS A0A7H2BE22_9MICC/5-145   AC A0A7H2BE22.1
#=GS A0A5B1LZV2_9ACTN/5-145   AC A0A5B1LZV2.1
#=GS A0A4Q4ZBL4_9ACTN/6-146   AC A0A4Q4ZBL4.1
#=GS A0A9X1N9S4_9ACTN/15-155  AC A0A9X1N9S4.1
#=GS A0A0Q7JGG2_9ACTN/5-145   AC A0A0Q7JGG2.1
#=GS A0A518SAX7_9EURY/4-143   AC A0A518SAX7.1
#=GS A0A9E6XZ11_9ACTN/9-149   AC A0A9E6XZ11.1
#=GS A0A4T0UNV3_9ACTN/6-146   AC A0A4T0UNV3.1
#=GS A0A0H5CCU3_9PSEU/5-145   AC A0A0H5CCU3.1
#=GS A0AAE3TPF2_9EURY/4-143   AC A0AAE3TPF2.1
#=GS A0A930VLH0_9ACTN/6-146   AC A0A930VLH0.1
#=GS A0A6G2G0V8_9EURY/4-143   AC A0A6G2G0V8.1
#=GS A0A511V1W9_9BACL/13-152  AC A0A511V1W9.1
#=GS A0A0P9H8T1_9CHLR/86-227  AC A0A0P9H8T1.1
#=GS A0A7V7ZPH8_9CHLR/68-209  AC A0A7V7ZPH8.1
#=GS E7QRJ1_HALPU/8-144       AC E7QRJ1.1
#=GS Q5UWU2_HALMA/4-143       AC Q5UWU2.1
#=GS A0A9R1CRL1_9EURY/4-143   AC A0A9R1CRL1.1
#=GS A1SNE5_NOCSJ/6-147       AC A1SNE5.1
#=GS Q4FPY0_PSYA2/56-195      AC Q4FPY0.1
#=GS R4W7D5_9EURY/4-143       AC R4W7D5.1
A0A0U5H5F1_9EURY/4-143              .....LVWLLDRGAALVAYPALYLSVLTGIFYN.....T.E......A..F.G..T.L..H...E.A.A.R..RVHIEVSVFATLVTLLH.AgL.G.IL.DAWF.......-VLS.GQAPPPAYSTS..Y.FLgGVVVGVGAL...FL.LV.V.AVLG.F.TDAGRF.D...RPWGPRVVHSFAYGGFTFGTIHAAAIGTD....
A0A4T0V026_9ACTN/5-145              .....LLWYLDRSTGLLLVLLLGAVTALGVLTS....gG.R......P..A.G..R.L..P...RfA.T.Q..ALHRNLALVSLALLAAH.V.LlA.VA.HEYVd.....iRLVD.AVLPGVARWEP..L.WL.GLGTIATD-...LI.LV.V.AVTS.G.LRARLG.G...RSW--RAVHLSAYAAWLLGTLHGLGIGTD....
A0A3N0GTH2_9ACTN/14-154             .....MLWYLNRGSGVALLLVLTATLCLGILSA.....R.A......G..R.S..R.LvpR...F.V.G.Q..QLHRNLGVLALVLVVGH.VaT.A.VA.DTYV.......DIRW.WQAVSPVGATYkpL.WL.GLGSLSFDV...ML.L-.V.VLTS.L.LRHRMG.Q...RSWH--AVHLLGYLSWPLAVVHSVGIGTD....
A0A975T079_9ACTN/6-146              ....f-LWYANRGTGVVLLVLLTLTTVLGVLAT.....R.G......D..A.GsrV.P..R...F.L.T.Q..SFHRNLALVSTVLLVVH.VaT.A.VV.DEYV.......DIRW.WQAFVPVGATY..Q.PL.WLGLGTVAL...DL.VA.V.VVLS.S.LLRARLsH...RSW--RVLHLSAYACWAVSVLHGQGIGTD....
A0A930VF35_9ACTN/4-143              ....w-VWWVDRGAGIVLLALLTSAVVTGLWSA.....ApR......R..R.G..M.P..R...F.A.T.L..ALHRNLALLAVTLLAVH.VgT.A.VV.DTFV.......EIRW.WQVVVPATSGF..R.PL.WVGFGTVAV...DL.LLaV.VATS.L.VRHRLG.L...RAW--RAVHLAVWPAWGLGVGHALALGTD....
A0A6B9F116_9EURY/4-143              .....LVWLLDRGAALIAYPALYLAVLTGILYS.....I.E......P..F.G..I.L..Q...R.A.S.Q..RVHVELSVFAMLVTLLH.AgV.G.LL.DTLF.......-IVT.GQAPAPAYPLS..Y.FLgGVAVGVGAL...LL.LV.V.AVRG.F.TEATRF.D...QPWGPRVVHAFAYGGFVFATVHAAAVGTD....
A0A1I0V6V1_9BACL/9-148              ....t-VWTTTRAAGITCYLLLFVSTGAGILTS.....L.K......L..F.G..P.K..T...R.AgA.L..FLHQSAGWFGFLFGALH.GsV.L.MF.DKYVg.....ySPLE.LLVPFAARTHP..Y.LM.GIGTLSFYI...TL.VL.I.ASSD.M.M--KRLgK...KNW--RAIHFLAFPGFFMGLVHGLLLGTD....
D4GTD9_HALVD/65-209                 lvgti-----SRVSMEHSYTLMFLATLTGILSR.....R.G......T..P.G..L.V..R...L.R.A.Q..RVHTLLAYGAGALVALH.V.L.T.QL.DSLSliadvlsQVVTgGLAGVDTRGLS..K.AV.GVGIGLCAV...VV.TT.V.AAVS.F.LRPRLF.T...GSVRPYVVHAFVYAGFA--TIHALVLGH-e...
A0A3A6PSJ4_9EURY/4-143              .....VIWYLDRAAGLLAYPSLTLAVLTGIGYN.....S.P......S..F.G..V.L..H...T.A.A.Q..RVHIEVSVFAMIVTLLH.AlI.G.VV.DTWN.......-VLS.GQVPPPAYSLS..Y.FSaGVIVGGGAL...LL.LV.V.AVLG.F.TDPARF.S...RPWGPRVVHTFAYGGFMFGTIHAAAIGTD....
E1ICQ4_9CHLR/98-239                 ....a-YWYLARSSAFVSYGLLWLAMIFGLLMT.....S.R......A..A.R..L.WpgG...P.V.A.F..DLHQHASLLGLAFALFH.A.L.I.LLgDAYI.......QADLrQVLVPFAYTGY..Q.PL.WVGLGQVGF...YL.ML.I.VSLS.FyLKGMLG.R...TAW--RVIHTLSFAMFVLALAHGVLSGSD....
A0A4R5BVH5_9ACTN/81-222             .agaf----LDFYCGVFALVALSLTVMIGLLAT.....D.R......A..VlA..P.R..H...R.VrA.Q..AVHRAFAFLAVSMLLLH.L.A.T.QL.ARH-.......RVGA.GQAFLPHS-RG..H.LA.DVGLGTLAF...YL.LI.I.AIAG.G.VARGRF.AaarHPWAWRATHLTAYAAWPLGILHGLT----sgra
A0A1H3E917_9EURY/4-143              .....LVWLLDRGAALVTYPALYLAVLTGILYN.....T.E......S..F.G..M.L..H...E.A.A.Q..RIHIELSVFAMIVTLLH.AgL.G.VL.DTWF.......-VVT.GQVPAPAYSMP..Y.FLgGIAVGAGAL...LM.LV.V.AVLG.F.TDAKRF.Q...RPWGPRVVHSFAYAGFAFGTIHAAAIGTD....
A0A418Q5J8_9CORY/6-152              .....LMWFANRGAAVAAFAALTMSVALGLYSSaglraT.RrlawmgR..F.R..P.H..R...G.L.P.L..QLHASMSLAALVALAIH.I.VtT.LL.NTHV.......P---.--VSVLDVVVP..F.RV.GIAYGLGAIafdLL.LI.T.AATG.W.LRNRLP.Q...RAW--RVVHSAAYICWPVALIHAVAAGTD....
A0A417Y4S2_9ACTN/5-145              .....MLWFLNRGTGMVLLGVLTATVLLGVLAA.....R.G......R..A.G..S.L..Lp.aF.V.S.R..SLHRNLSLFGAILLVAH.IaT.A.VL.DEFV.......DIRW.WHAFVPYGAAY..E.PW.WLAVGTLAS..dLI.LA.V.LVTT.A.VRGRLG.L...RCWQ--RVHQLAYLAWALGLVHGLMIGSD....
A0A830EJ65_9EURY/4-143              .....VVWYLDRGAALIAYPSLYLAVLTGILYN.....T.P......S..F.G..I.L..H...T.A.A.Q..RVHIELSVFAMVLTLLH.AaV.G.LV.DSWM.......-VVTgQVPEPAYSVTY..F.VI.GVGVGFGAL...VL.LV.V.AVLG.F.IDAQRF.K...QPWGPRVVHAFTYAGFAFGTIHAVAVGTD....
A0A0T2IHG9_9MICO/5-144              .....LLWYLNRGTGLVLLAVFTLTVVLGVLST.....G.Q......G..G.R..V.W..P...RfA.T.Q..STHRGLSLLTTLLLLAH.A.VtA.VV.DEFV.......DIRW.WQALLPFGGTY..R.PL.YLGLGTLAL...DLtLA.V.GATS.L.LKQRLG.E...RAW--RAVHLMSYLAWTAAVVHTLGIGTD....
A0A7M2YUX8_9ACTN/6-145              ....t-FWLLARAGGLTAYVMLTLSVLAGLVLK.....A.R......P..F.R..A.L..K...P.A.AvT..DLHRVLALLGLGALAMH.G.IaL.VL.DTTV.......EVSP.LGLLVPGLVSY..R.PV.WTALGVLAA...EM.MV.L.VYAS.F.SVRKRI.K...-VKNWRRLHWATYGIFAAATVHGIAGGTD....
M1XPV6_NATM8/4-143                  .....LVWLLDRGAALITYPLLYLAVLTGIFYN.....T.E......S..F.G..V.L..H...E.A.A.R..RIHVELSVFAMIVTLLH.AgL.G.VL.DAWF.......-VVIgAVPAPAYSMPY..F.FG.GVAVGAGAL...LM.LV.V.AVVA.F.IDPKRF.Q...RPWGPRVVHSFAYAGFAFGTIHAAAIGTD....
A0A1S8ART1_9EURY/3-142              .....IIWHLDRSAALVAYPALYLAVLTGILYT.....A.R......S..F.G..P.L..Y...R.L.A.R..KIHIEVSVFAMLVTLLHgV.L.G.VL.DTWF.......-IVT.GSAPQPAYSTT..YlLA.GVVVGVGAL...QV.LA.V.AALG.F.LDAERF.D...RPWGPRIVHAFAYGGFAFATVHAAAVGTD....
A0A1V1VYZ4_9ACTN/6-147              ....f-LWYLNRGTGFVILGLFTMTTALGVLAT.....G.G......R..A.GrgL.P..R...F.V.T.Q..SLHRNLALLSVVMLAVH.VtT.A.VV.DSYV.......DIRW.WQTLVPWAGST..YePV.WLGLGALAL..dLF.LV.V.AVTS.A.VRARMR.H...RSW--RAIHLLAYAGWVAAVVHGLGIGTD....
A0A7H2BE22_9MICC/5-145              .....ILWDIGRGTGVVASVLLTVTVMLGIYGR....sA.R......T..FlG..I.P..R...F.A.M.I..SIHRTASLFSVVFTLVH.V.LtV.TL.DQYT.......NLTF.INAFIPFISSN..E.PL.WYGLGAIAL..dLL.LA.I.SVTG.M.LRSYIG.E...KTFH--AVHWLAYASWPIAIIHGLGAGTD....
A0A5B1LZV2_9ACTN/5-145              .....MLWFLNRGTGMALLAVLTISVCLGVLAT.....R.G......R..A.G..S.QvpA...F.V.T.R..ALHRNLSLFGMALLAGH.I.VtA.VL.DEFV.......DIRW.WIAFVPYGSGY..E.PL.WVAAGTVAT..dLF.LA.V.VVTT.M.VRARLG.L...SRWH--RVHQLAHLAWALGLVHGLAIGTD....
A0A4Q4ZBL4_9ACTN/6-146              .....LLWYVNRGTGVVLLVLLTGSVVLGVLAT.....S.G......R..A.GsrV.P..Q...F.V.R.Q..GLHRNLSLLSVAMLAVH.VaS.A.VL.DSFV.......DIRW.RDAFLPVGGSY..R.PV.WLGLGALSL...DL.LA.V.VVAT.S.LLRTRIpH...RSW--WLVHLLSYLAWAAAVAHSVGIGTD....
A0A9X1N9S4_9ACTN/15-155             .....LLWFLNRGTGVILLVLMTVSVGLGVLST.....V.R......A..S.S..V.FwpR...F.V.T.Q..QLHRNVSLLSVALLIAH.AaL.A.VV.DEYV.......NIRW.WDAFVPFLGEY..Q.PL.WLGLGTVAT...DL.VI.I.TVLT.G.LSRTRF.R...-SRTWRTIHLTSYLGWGAGLVHGFGIGTD....
A0A0Q7JGG2_9ACTN/5-145              ....a-LWFANRGTGVVLLVVVTLSTVLGVLST.....A.R......A..G.S..R.LwpR...F.L.T.Q..GLHRNVALLGVALTLAH.AgT.A.VI.DEYV.......DIRW.WQALVPFGATY..R.PF.WLSLGTLAF...DL.ML.A.AAGT.S.LLRHRM.R...H-GLWRAIHVSTYAVFALGVVHGIGIGTD....
A0A518SAX7_9EURY/4-143              .....IIWYLDRGAALVAYPALYLAVLTGILYN.....T.A......S..F.G..V.L..H...E.A.A.Q..RVHIEVSVFAMIVTLLH.AgL.G.VL.DTWF.......-VIT.GQAPAPAYSMT..Y.FLgGIAVGVGAL...LM.LV.V.AVLG.F.TDANRF.Q...RPWGPRVVHSFAYAGFAFGTIHAAAIGTD....
A0A9E6XZ11_9ACTN/9-149              ....a-LWYVSRGTGLTALIALTASVVLGILHA.....D.Rr....rP..A.G..A.P..R...M.L.V.E..SAHRTLSLLVLALLAVH.IaT.T.VL.DPFA.......PIRL.ADAVIPFASSY..R.--.PLWLGLGAL...AF.DI.L.AAVA.I.TSALRL.RlgaRAW--RAVHWLAYACWPLAVVHGLGTGTD....
A0A4T0UNV3_9ACTN/6-146              .....LLWYLNRATGVVVLVLLTLSVVLGVLAL.....G.G......RpgR.G..L.P..R...F.V.T.Q..SLHRNLALLSVVTLVVH.VaT.A.VL.DTYV.......DIRW.WQALSPVGATY..R.PV.WLGLGAVAL...DL.MA.V.VVLT.S.LVRARLrH...RAW--RAVHVLSWLAWTAAAAHAVGIGTD....
A0A0H5CCU3_9PSEU/5-145              ....l-WWYLARVGGLMSWWLLSATVVWGLLLY.....T.R......V..L.G..P.R..T...T.T.A.RlfDLHRFLSVLSLVFLAVH.V.L.AlVA.DSWV.......DVGL.PQLLFPFTSDF..R.PV.AVAWGVIAV...YLlLA.V.EVTS.L.LR-RRI.P...HRWW-RYVHTCAFAVFALGTVHALTAGTD....
A0AAE3TPF2_9EURY/4-143              .....IVWYLDRGAALVAYPALYLAVLTGILYN.....T.E......S..F.G..V.L..H...E.A.A.R..RVHVEVSVFAMIVTLLH.AgL.G.VF.DAWF.......-VVN.GQVPAPAFSTS..Y.FIgGIVVGAGAL...LM.LV.V.AVLG.F.TDAQRF.Q...RPWGPRVVHSFAYAGFAFGTVHAAAIGTD....
A0A930VLH0_9ACTN/6-146              .....LLWYVNRATGVVLLLLLTLTVVLGVLSV.....R.G......S..H.G..R.RlpA...F.V.T.Q..DLHRNLALLGVVMLGVH.IaS.A.VV.DSYV.......DIRW.WQALVPAGATY..E.PV.WLGLGALAF...DF.LL.VlVVTS.L.VRTRLG.H...RSW--RAVHLSAWVAWCLSVVHGIGIGTD....
A0A6G2G0V8_9EURY/4-143              .....LVWLLDRGAALVTYPLLYLAVLTGVLYN.....T.E......S..F.G..V.L..H...E.A.A.Q..RIHIELSVFAMIVTLLH.AgL.G.VL.DAWF.......-VVT.GQVPAPTYSIP..Y.FLgGVAVGAGAL...LM.LV.V.AVLG.F.TDAKRF.E...RPWGPRVVHSFAYAGFAFGTIHAAAIGTD....
A0A511V1W9_9BACL/13-152             ....s-VWHLTRAAGLVAYGLLFTAVMTGILQS.....M.R......I..L.P..LpL..R...P.A.L.A..AIHNAASWFGLMFALLH.G.C.VlLF.DDYV.......TYTA.WEIAVPFLSDH..E.SV.KEAAGILSF...YL.FF.L.LILS.SdLQKKIG.R...RAW--RLIHYDAFLAYALALTHGVILGTD....
A0A0P9H8T1_9CHLR/86-227             ....a-YWYLARASAFVAYGLLWLSMMLGLTMT.....N.K......L..A.R..V.WpgG...P.V.A.F..DLHQHTSLLGLAFALFH.A.L.V.LLgDRYI.......GYSL.AQILMPFASTA..YkPL.EVGLGQIAL...YL.LA.L.VGLS.F.YVRALIgR...KLW--RSVHFLSFALFVLALLHGVGSGTD....
A0A7V7ZPH8_9CHLR/68-209             ....a-FWYLSRSSAVVAYALLWLSMASGLLIS.....D.-......R..F.A..K.L..WpggP.A.A.F..DLHQQSSLLGLAFGLFH.A.L.V.LLgDRYI.......QASLgQILTPFAYPQE..A.QL.WVGLGQISI...YG.MV.I.TCAS.F.YARQQL.G...RR-AWRAIHAISYGVFALALAHGLMSGSD....
E7QRJ1_HALPU/8-144                  ....a-LWYLDRASALVLYPALWLTVLTGVFFT.....E.R......R..F.G..A.I..H...W.L.S.L..RTHIELAVFAVGMMVLH.AvV.G.TI.DAWL.......-VVD.GIAPAPNYPFP..L.FIaGVGVGGVAV...VL.VV.V.AVLG.F.LEPRRF.E...---HPKAIHALAYGGFAFATIHAVAIGSD....
Q5UWU2_HALMA/4-143                  .....LVWLLDRGAALVTYPALYLAVLTGILYN.....T.E......S..F.G..M.L..H...E.A.A.Q..RIHIELSVFAMIVTLLH.AgL.G.VL.DAWF.......-VVT.GQVPAPAYSMP..Y.FLgGVAVGAGAL...LM.LV.V.AVLG.F.TDAKRF.Q...RPWGPRVVHSFAYAGFAFGTIHAAAIGTD....
A0A9R1CRL1_9EURY/4-143              .....LVWLLDRGAALVAYPTLYLAVLTGIFYN.....T.E......P..F.G..V.L..H...E.A.A.Q..RVHIELSVFAMVVTLLH.AlL.G.IL.DTWF.......-VVT.GEAPLPAYSRS..Y.FVgGVVVGVGAL...LL.LV.V.AVFG.F.VDAKRF.S...RPWGPRVVHSLAYGGFAFGTIHAAAIGTD....
A1SNE5_NOCSJ/6-147                  ....s-LWYLNRSTGFVLLGLFTLTTALGVLAT.....G.G......R..A.GrgL.P..R...F.V.T.Q..TMHRNLALFSVVALGVH.VtT.A.VV.DSYV.......DIRW.WQALVPYVGST..Y.LPlWLGLGTLAV...DLaLV.V.TVTS.L.LRTRMR.H...RSW--RAVHVLAYAGWAASVAHSIGIGTD....
Q4FPY0_PSYA2/56-195                 ....h-FWYLSRASGVVAYSLFWLAVVFGLLLS.....T.R......-..L.G..K.H..V...N.A.A.RvfALHQYLSLIAVGFAAFH.A.GiL.LA.DNYL.......NLNI.WQILLPFGFQT..E.RV.GVALGQLGF...WL.LF.I.CAFS.F.YIKQYI.G...Q-SAWRWLHFLTFFSYMFISIHVFMVGSD....
R4W7D5_9EURY/4-143                  .....LVWLLDRGAALVTYPALYLAVLTGILYN.....T.E......S..F.G..M.L..H...E.A.A.Q..RIHIELSVFAMIVTLLH.AvL.G.VL.DAWF.......-VVT.GQVPAPAYSMP..Y.FLgGITVGAGAL...LM.LV.V.AVLG.F.TDAKRF.Q...RPWGPRVVHSFAYAGFAFGTIHAAAIGTD....
#=GC seq_cons                       ......lWaLsRuuulVshslLhLuVlhGlLhs.....s.c......s..h.G..h.h..+...h.s.u.p..plHppLSlhuhlhhllH.shl.u.Vl.Dsah.......tlhh.hpshsPshush..h..l.hlulGshAl...hl.Ll.V.sVhu.h.lcspph.p...RsW..RsVHhhAYuuashuslHululGTD....
//