#=GF ID Dredd_2nd
#=GF AC PF23724.1
#=GF DE Caspase-8, second domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE ECOD:Q8IRY7_D2
#=GF GA 27.00 27.00;
#=GF TC 28.70 27.10;
#=GF NC 23.40 26.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 81514348 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0041
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in Caspase-8 from Drosophila melanogaster
#=GF CC (Dredd) and similar proteins mainly found in insects. Dredd is
#=GF CC an effector of the programmed cell death (PCD) activators rpr,
#=GF CC grim and hid. It plays a role in the innate immune response and
#=GF CC may be involved in apoptosis in the germline as well as soma.
#=GF CC This protein is predicted to be organised into three domains: an
#=GF CC N-terminal, this entry, and a caspase domain (Pfam:PF00656).
#=GF CC This domain is predicted to adopt an all-alpha configuration.
#=GF SQ 116
#=GS A0A836EWI9_9HYME/125-197 AC A0A836EWI9.1
#=GS A0A6J1MJQ8_BICAN/126-224 AC A0A6J1MJQ8.1
#=GS X2JHT0_DROME/62-161 AC X2JHT0.1
#=GS A0A6I8TFZ5_AEDAE/112-205 AC A0A6I8TFZ5.1
#=GS A0A6P9ADC9_THRPL/123-217 AC A0A6P9ADC9.1
#=GS B4N271_DROWI/123-226 AC B4N271.1
#=GS A0A7M7GGK5_NASVI/126-208 AC A0A7M7GGK5.1
#=GS CASP8_DROPS/119-215 AC Q29IM7.1
#=GS A0A4C1VWG9_EUMVA/115-212 AC A0A4C1VWG9.1
#=GS A0A0C9QWR7_9HYME/126-218 AC A0A0C9QWR7.1
#=GS B0X6C0_CULQU/107-200 AC B0X6C0.1
#=GS CASP8_DROME/116-215 AC Q8IRY7.3
#=GS A0A8J9Y909_9NEOP/126-224 AC A0A8J9Y909.1
#=GS A0A6J2TTX1_DROLE/125-234 AC A0A6J2TTX1.1
#=GS A0A8S4RT59_9NEOP/126-224 AC A0A8S4RT59.1
#=GS W5JJK4_ANODA/107-201 AC W5JJK4.1
#=GS A0A484B0N7_DRONA/114-217 AC A0A484B0N7.1
#=GS A0A9J7DW14_SPOLT/140-237 AC A0A9J7DW14.1
#=GS A0A0M8ZUG3_9HYME/121-202 AC A0A0M8ZUG3.1
#=GS A0A922CJJ7_MANSE/128-227 AC A0A922CJJ7.1
#=GS A0A0L7RG46_9HYME/122-214 AC A0A0L7RG46.1
#=GS A0A8S9X764_APOLU/129-214 AC A0A8S9X764.1
#=GS A0A212FDA5_DANPL/89-187 AC A0A212FDA5.1
#=GS A0A194QJI1_PAPXU/125-221 AC A0A194QJI1.1
#=GS A0A834K095_VESPE/122-222 AC A0A834K095.1
#=GS A0A5E4R1P6_9NEOP/121-216 AC A0A5E4R1P6.1
#=GS A0A7E5V8W2_TRINI/130-229 AC A0A7E5V8W2.1
#=GS A0A0L0CNR9_LUCCU/658-754 AC A0A0L0CNR9.1
#=GS A0A1J1HLU3_9DIPT/97-189 AC A0A1J1HLU3.1
#=GS B3MYZ3_DROAN/116-217 AC B3MYZ3.2
#=GS A0A195EBU4_9HYME/126-219 AC A0A195EBU4.1
#=GS A0A9J6BMQ6_POLVA/97-188 AC A0A9J6BMQ6.1
#=GS A0A8S0ZP02_ARCPL/131-224 AC A0A8S0ZP02.1
#=GS A0A6P7FAC6_DIAVI/173-261 AC A0A6P7FAC6.1
#=GS A0A182YJE3_ANOST/49-142 AC A0A182YJE3.1
#=GS A0A151IPZ8_9HYME/130-223 AC A0A151IPZ8.1
#=GS B4L579_DROMO/114-217 AC B4L579.2
#=GS A0A482VRD0_9CUCU/148-238 AC A0A482VRD0.1
#=GS A0A8J5RJX6_9HYME/130-211 AC A0A8J5RJX6.1
#=GS A0A6A4JJM6_APOLU/129-214 AC A0A6A4JJM6.1
#=GS B4I943_DROSE/116-215 AC B4I943.1
#=GS T1GWX8_MEGSC/110-196 AC T1GWX8.1
#=GS A0A6J1WR13_GALME/124-222 AC A0A6J1WR13.1
#=GS A0A7M7GZS1_APIME/121-215 AC A0A7M7GZS1.1
#=GS A0A2J7QKG1_9NEOP/168-232 AC A0A2J7QKG1.1
#=GS A0A0L0CNR9_LUCCU/130-227 AC A0A0L0CNR9.1
#=GS A0A6P4HQ37_DROKI/117-218 AC A0A6P4HQ37.1
#=GS A0A834J573_VESVU/122-223 AC A0A834J573.1
#=GS B4R7G3_DROSI/116-182 AC B4R7G3.1
#=GS A0A6I9VJ20_BACDO/125-222 AC A0A6I9VJ20.1
#=GS A0A2J7QKF2_9NEOP/159-258 AC A0A2J7QKF2.1
#=GS A0A154NWC5_DUFNO/122-216 AC A0A154NWC5.1
#=GS A0A8S3WZN8_PARAO/126-224 AC A0A8S3WZN8.1
#=GS A0A0L7LPH4_OPEBR/140-238 AC A0A0L7LPH4.1
#=GS B4H2Q9_DROPE/87-183 AC B4H2Q9.1
#=GS A0A0T6AWY1_9SCAR/139-233 AC A0A0T6AWY1.1
#=GS A0A1W4WH04_AGRPL/181-284 AC A0A1W4WH04.1
#=GS A0A6J3KAZ6_9HYME/121-215 AC A0A6J3KAZ6.1
#=GS A0A1S4H7C5_ANOGA/106-199 AC A0A1S4H7C5.1
#=GS A0A5N4AZ53_PHOPY/128-217 AC A0A5N4AZ53.1
#=GS A0A1W4W5J4_AGRPL/162-265 AC A0A1W4W5J4.1
#=GS A0A2J7QKF5_9NEOP/168-267 AC A0A2J7QKF5.1
#=GS A0A836JZP6_9HYME/114-207 AC A0A836JZP6.1
#=GS A0A2J7QKE1_9NEOP/168-267 AC A0A2J7QKE1.1
#=GS A0A1W4W5I4_AGRPL/132-235 AC A0A1W4W5I4.1
#=GS N6TGN6_DENPD/195-281 AC N6TGN6.1
#=GS A0A310SUV1_9HYME/122-216 AC A0A310SUV1.1
#=GS A0A833RYR4_9HYME/121-215 AC A0A833RYR4.1
#=GS A9ZMY8_BOMMO/130-227 AC A9ZMY8.1
#=GS F4WNG8_ACREC/216-308 AC F4WNG8.1
#=GS A0A821X9B3_9NEOP/118-212 AC A0A821X9B3.1
#=GS A0A6P4F8C4_DRORH/116-215 AC A0A6P4F8C4.1
#=GS A0A6J1RW79_FRAOC/121-217 AC A0A6J1RW79.1
#=GS A0A1I8M1X4_MUSDO/125-223 AC A0A1I8M1X4.1
#=GS A0A158NXZ1_ATTCE/115-208 AC A0A158NXZ1.1
#=GS A0A4S2L5U4_9HYME/122-215 AC A0A4S2L5U4.1
#=GS A0A8K0CDA9_9COLE/172-263 AC A0A8K0CDA9.1
#=GS A0A834INZ1_RHYFE/147-232 AC A0A834INZ1.1
#=GS D6WJH5_TRICA/158-248 AC D6WJH5.1
#=GS A0A6P3X5A5_DINQU/120-213 AC A0A6P3X5A5.1
#=GS A0A084WBG7_ANOSI/107-200 AC A0A084WBG7.1
#=GS E1ZVM8_CAMFO/118-186 AC E1ZVM8.1
#=GS A0A834MTE2_VESGE/122-222 AC A0A834MTE2.1
#=GS A0A0M4EZM9_DROBS/115-217 AC A0A0M4EZM9.1
#=GS A0A232F6M9_9HYME/126-208 AC A0A232F6M9.1
#=GS A0A6P8ZG92_DROAB/114-217 AC A0A6P8ZG92.1
#=GS A0A2J7QKF9_9NEOP/168-267 AC A0A2J7QKF9.1
#=GS A0A7R8YN34_HERIL/121-213 AC A0A7R8YN34.1
#=GS A0A6I9WL82_9HYME/117-213 AC A0A6I9WL82.1
#=GS A0A194QL32_PAPMA/125-221 AC A0A194QL32.1
#=GS A0A6L2PW42_COPFO/85-184 AC A0A6L2PW42.1
#=GS A0A6J0BRU9_NEOLC/117-209 AC A0A6J0BRU9.1
#=GS A0A6J2XJ59_SITOR/153-233 AC A0A6J2XJ59.1
#=GS A0A8J2VXE2_9NEOP/127-225 AC A0A8J2VXE2.1
#=GS E0W1C4_PEDHC/120-216 AC E0W1C4.1
#=GS A0A8S4EFK1_PLUXY/180-277 AC A0A8S4EFK1.1
#=GS B4JNA9_DROGR/115-215 AC B4JNA9.1
#=GS A0A6J2TRC5_DROLE/114-223 AC A0A6J2TRC5.1
#=GS A0A653BKU8_CALMS/160-252 AC A0A653BKU8.1
#=GS A0A835CWB2_9HYME/123-216 AC A0A835CWB2.1
#=GS A0A151WV87_9HYME/115-208 AC A0A151WV87.1
#=GS A0A8J6HK89_TENMO/105-194 AC A0A8J6HK89.1
#=GS A0A067QV28_ZOONE/69-167 AC A0A067QV28.1
#=GS A0A182H1W5_AEDAL/112-205 AC A0A182H1W5.1
#=GS E2BE23_HARSA/105-159 AC E2BE23.1
#=GS A0A026WDB3_OOCBI/101-194 AC A0A026WDB3.1
#=GS A0A2A4KAV9_HELVI/130-228 AC A0A2A4KAV9.1
#=GS A0A6I8WCV0_DROPS/119-215 AC A0A6I8WCV0.1
#=GS B4M7Y9_DROVI/112-215 AC B4M7Y9.1
#=GS A0A6J1RUQ9_FRAOC/121-217 AC A0A6J1RUQ9.1
#=GS A0A8K0P339_LADFU/1-80 AC A0A8K0P339.1
#=GS A0A2A3E9L8_APICC/72-166 AC A0A2A3E9L8.1
#=GS A0A195B8D0_9HYME/114-207 AC A0A195B8D0.1
#=GS A0A195FXN4_9HYME/126-219 AC A0A195FXN4.1
#=GS A0A8J2MM11_COTCN/130-211 AC A0A8J2MM11.1
#=GS A0A8B8ICL6_VANTA/126-224 AC A0A8B8ICL6.1
A0A836EWI9_9HYME/125-197 ..s-KSINVIAKCL.YKLCESLNESEQKILLSYVK...SEIH.....--....N..Y.......DPLLD-NV.DYLELHMLYWIQIGYITISK--......--.......-----------.-.----------------gmftltynl.........................
A0A6J1MJQ8_BICAN/126-224 ..n-VYIDPVKKVL.YNLCEQMTSENYQKLKRTLT...TY--.....--....-..-.......-NIDVSEH.ESCEAVFLELMCQKFIKLGTYN......TErka.ytaTYDLEKLITII.EnFGGLSKYATILKEVQN..................................
X2JHT0_DROME/62-161 ...TLHVHPLLKSL.YRMCEELSLVQSGRLLLDVR...EKVE....sQQ....A..G.......DPLRFYDP.AYLEIFLLDWLTRRSIKLGDIN......AA.......GSDVQLLVGHL.K.SNGLQAQANLLKDTI-i.................................
A0A6I8TFZ5_AEDAE/112-205 ...ATHVHPVLKGL.WLLCEKMDRATSDRLENYLR...QNY-.....--....-..-.......-ALAVMDS.EFLEMIMLDMIGQGVIKLGSKE.....gGQ.......VSDLSNLIAAF.K.ALEMEGLKDFCKNIE-s.................................
A0A6P9ADC9_THRPL/123-217 ...SCHVDLIRKVL.YLMVDDLSKDDWNDLRLLII...EETK.....--....-..L.......QSVPAKYT.EIPECLLLILMSRNFIQLKK-K......DQ.......RVNLSLLFSCL.K.RLGKDYWAHQLKSIEN..................................
B4N271_DROWI/123-226 ...TLHIHPLLKAL.YVICEQLTEHQSGRLVLDIT...DMLArrlgpNN....M..G.......DPFRFYDF.KYLEIFLLDWICRRFLQLGDIN......AK.......GSNVEILIEYF.K.SKDMSVQAKLLIDTIN..................................
A0A7M7GGK5_NASVI/126-208 sen---LNKVIKSL.YFVCSNLDTKEVSKLITKVN...ERLC.....--....S..P.......VQLNS-NK.LWLEVYILYWLQQNYISINE--......-D.......NPNLNNLIEDL.K.SIG-------------cli...............................
CASP8_DROPS/119-215 ..r-VHIHPLLKSL.YTICEELTLAQRGRMVLDIK...EK--.....NS....V..G.......DPLRFYDA.EYLEIFLLDWLTRRLIRLGDFN......AN.......GSDVQLLIEYF.K.FNDLHAQATLLVDTVN..................................
A0A4C1VWG9_EUMVA/115-212 ..t-HYINPMKKLL.YKICENIQMENLLKLKKTLV...TF--.....--....-..-.......-DIDVQEY.ETCELIFLKLIVEEFIMIGSWKte.ckiQE.......QCNMKNLTNIF.RnLQGLMKFALELQE---aen...............................
A0A0C9QWR7_9HYME/126-218 .rt--QVHIGAKLLfYLFDKDLGEKERIKLLGKVY...EQIR.....--....P..P.......EELKN--N.DPMEIHALYWIQQRYIALTS--......DG.......RGNLENLLKPL.K.AMGLSEHTRYL-----dlqk..............................
B0X6C0_CULQU/107-200 ..t-SFVHPVLKGL.YLLCEKMDDGLAGKVIDYLK...KTH-.....--....-..-.......-SVGVLNS.RFFELVLLELISEDFVKLGSKS.....aGE.......ECDLLLLVACF.K.SLDLYDLAEFCKRIS-d.................................
CASP8_DROME/116-215 ...TLHVHPLLKSL.YRMCEELSLVQSGRLLLDVR...EKVE....sQQ....A..G.......DPLRFYDP.AYLEIFLLDWLTRRSIKLGDIN......AA.......GSDVQLLVGHL.K.SNGLQAQANLLKDTI-i.................................
A0A8J9Y909_9NEOP/126-224 ..n-IYIDPMKKVL.YRLCESMTTKHMTKLKKTLL...SY--.....--....-..-.......-KIDVSNC.EATEVLFLELICKKFITLGQYStdmktyTN.......KYEMDQLVGIL.EsFNGLTEFALTIKEIQ-s.................................
A0A6J2TTX1_DROLE/125-234 ...TLHVHPLLKAL.YIVCEQLTLAQSSRLVLSISdmqTRIN....aQQ....Q..GpesasanDRLLIYDF.AYLEIFLLHWLTRRIIKLGDIN......AE.......GSDMQILIEYF.K.FNNLESLSSLLIQTIN..................................
A0A8S4RT59_9NEOP/126-224 ..n-VYIDPVKKVL.YNLCESMTSENYAKLKRTLT...TY--.....--....-..-.......-KIDVSEH.ETCEAVFLELMCQKFIKLGQYNretkayTA.......TYDVELLIKII.KpFGALSKFATILREVQ-s.................................
W5JJK4_ANODA/107-201 ...AVKVHPLLKGL.YHFCERLDDANARKLAKQLG...QPYG.....--....-..-.......-GTSDVAE.NCFEVVLLRLLSSEAVRLGSKT.....eSQ.......ECDLLTLSAAC.K.AIELYDESYFLKGIA-d.................................
A0A484B0N7_DRONA/114-217 ...TLHVHPLLKAL.YNICEQLTVAQSGRLVLDIN...DKLA....rRRisgeH..D.......EPLRFYDY.SYLEIFLLDWLTRHHLRLGDID......AI.......GSDVQLLIEYF.K.FNDLNSLATLLIQTVN..................................
A0A9J7DW14_SPOLT/140-237 ..k-MYINPMKKAL.YKLCESINSDNLLKLKKALL...TY--.....--....-..-.......-ETDTTEY.ECCEQVFLKLMCDKFITINQYQ......YNkkv.lgfKVEIDKLVKIL.D.----------------nlpglkkllleinmlq..................
A0A0M8ZUG3_9HYME/121-202 ...SRYINLAAKCL.YLLCEALCEDKTKLLLQYIQ...TDLT.....-P....Y..E.......E--NLKNI.DFLELHMLYWTRENYISIY---......--.......-PDLGLICE--.-.----------------dlkkrenhqnv.......................
A0A922CJJ7_MANSE/128-227 ...SKYINPVKKVL.YHACENINSTNLLKLKKSLL...SY--.....--....-..-.......-DINVMEY.TTCELIFLELLSNKFITINNIG......QKiktnqncICNVENLVKIL.DnLNGLKKVAMNL-----ryfqs.............................
A0A0L7RG46_9HYME/122-214 ...SRYINVVAKCL.YLLCEALSEDRIKLLLQYVK...SDLT.....--....-..E.......YLKYLEDI.DFLELHMLYWMQENYISIQT--......--.......GGNLKNLLKHI.KrFDDLELIYEDLKNHEN..................................
A0A8S9X764_APOLU/129-214 rvl----NCNKITL.YKICEGLDVQHKKIFLRSMA...ESIP.....--....-..-.......KKMPIKGH.EYLEMYFMYWEISGAIDPST--......--.......RKGFDHVVKAL.H.ATGLTNLIE-------lif...............................
A0A212FDA5_DANPL/89-187 ...SIYTDPMKKVL.YKLCESLNSEIFSRLQKTLI...SY--.....--....-..-.......-NYNVSEY.RTCELVLLELISKRFIKLGYYDkdkksyTN.......TYDIEELAKIIeK.FSTVSILASVLREIQ-e.................................
A0A194QJI1_PAPXU/125-221 ..c-IYINPMKKAL.YKFCENVIVNILVRLKKSLL...TY--.....--....-..-.......-DIDTSEH.ESCELICLELISQKFITLNKNNfv..veNK.......QCHVEKLVRIV.EnIPGLKKVAEDLQIIA-n.................................
A0A834K095_VESPE/122-222 tkq---LNPIAKCL.YILCESLTVEETKALLHSVK...EDKIflsidKD....K..K.......YEAMLEEI.DQLELHLLYWMDIGYISIFS--......AK.......EGNLKDLLKHL.NaFDDI------------kpiirdlkcy........................
A0A5E4R1P6_9NEOP/121-216 ..t-SNVHPGKKLL.YRLCENITAENLDKLKKSLL...S-F-.....--....-..-.......-DIDTIEY.ESSELIFLELMSRKLIILPQPHn...lhEN.......KVDFGCLPEIL.KrFPELNEYTSYLIDMQ-d.................................
A0A7E5V8W2_TRINI/130-229 ..k-MYINPLKKAL.YKLCENINSDNLLKLKKTLL...TY--.....--....-..-.......-DIDTTEY.DSCELIFLKLMCIKFITIDQFQ.....yGKkv..lgyKVTLEKLLKIV.-.----------------enlpglkkivmeinllqqs...............
A0A0L0CNR9_LUCCU/658-754 ...SVYIHPLLKVL.YKIAERLTPEQAGRLIQYIH...TKY-.....-E....E..C.......QHLRFYDY.SYLEVFFLNWLLKRVIAVGNRN......LE.......NSNMQILIEFF.K.FNDMDSFKNLLLETIN..................................
A0A1J1HLU3_9DIPT/97-189 .nm--QINVGLKLL.FKFCDACYQNTTSSFISYIK...ENC-.....--....-..-.......HTAKHCNH.EMLEVYLLHLIISHQIIIT-KS......ID.......HCDFVFITNFL.K.GKKFHEVENVLVE---fpq...............................
B3MYZ3_DROAN/116-217 ...TLHIHPLLKSL.YTICEQMTVAQSGRLVLDVG...EKVA....rQQ....EgaG.......DPMHFNDP.AYLEIYLLDWLTRKAIKLGDIN......TN.......GSDVQLLIEHL.K.FNDLQEQAKLLIDTIN..................................
A0A195EBU4_9HYME/126-219 ..s-KSINVIAKCL.YKLCESLNESEQKLLLTYVK...SEIH.....--....-..N.......YEPLLDNV.DYLELHMLYWIQIGYITISK--......DK.......MHNMKKLLKHL.KkFE--------------grvkiicmelekf.....................
A0A9J6BMQ6_POLVA/97-188 .sh--LINSGIKLL.YELCESLTQDISDKLINFIK...DECN.....--....-..F.......ATIR--NV.DQLEIFLLHAIVNGKIKIAST-......LD.......ACDFSM-IHNF.KtTINVT-----------dqkilevlek........................
A0A8S0ZP02_ARCPL/131-224 ..k-MFINPIKKAL.YKLCENMNADNFLNLKKALF...TY--.....--....-..-.......-NIDASEY.ESCELVLLKLMCDKFIIVNEFKy....nTKtf...gfQVQLDKLLRII.-.----------------etlpglrtcaqei.....................
A0A6P7FAC6_DIAVI/173-261 ...SLQINKLKKAV.YLICDNFDSEATKTFLKYMR...QNFM.....-N....R..Q.......VQFNEFDVdDNLELYFLNWESNRQLNFE---......--.......-----EIKSIL.K.KMEQYRLYDM------lcsala............................
A0A182YJE3_ANOST/49-142 ...SFLVHPMLKGL.YNFCERLDDANASKLIVQLQ...ETT-.....--....-..-.......-GVSSLQN.QNMETVLLHLLCNGKIQLGSKQ.....sGQ.......ESNLLVLTAAC.K.AIELYDESDFLKSIV-s.................................
A0A151IPZ8_9HYME/130-223 ...SRSINVIAKCL.YKLCESLNESEQKLLLDYVK...SE--.....-N....H..N.......YEPLLDNV.DYLELHMLYWIQIGYITISK--......DK.......SYNMKRLLKHL.K.KFEDGHLKIICIE---lek...............................
B4L579_DROMO/114-217 ...TLHVHPLLKAL.YNVCEQLTVAQSGRLVLDIN...DKLA....rRRisgeH..D.......EPLRFYDY.SYLEIFLLDWLTRHHLRLGDID......AI.......GSDVQLLIEYF.K.FNNLNSLATLLIQTIN..................................
A0A482VRD0_9CUCU/148-238 ...SYNVSKVKKAL.YFLCESLTRTEAEQLLKLVF...TDF-.....ND....K..G.......LETKFFDS.SYLELYFLHWESVGYIK-----......--.......HDNFNNLYRIL.K.QLEHFDMCDSLKRVV-p.................................
A0A8J5RJX6_9HYME/130-211 .gk---INVGNKIL.FKFFESLSEKESEKILKKIY...SDIR.....--....-..-.......LDKRLSDI.HLMEIHALYWLSIGFIKITPAD......G-.......--DLSNLLKYL.K.P---------------lgyfdt............................
A0A6A4JJM6_APOLU/129-214 rvl----NCNKITL.YKICEGLDFQHKKIFLRSMA...ESIP.....--....-..-.......KKMPIKGH.EYLEMYFMYWEISGAIDPST--......--.......RKGFDHVVKAL.H.ATGLTNLIE-------lif...............................
B4I943_DROSE/116-215 ...TLHVHPLLKSL.YRMCEELSLAQSGRLFLDVG...EKVA....sQQ....A..G.......DPLRFYDP.AYLEIFLLDWLTKRSIKLGDIN......AA.......GSNVDLLVEHL.K.FNDLHAQAKLITDTI-i.................................
T1GWX8_MEGSC/110-196 ...SNYINLIVKNL.YILCEKLKISEGGKLILDQN...ND--.....--....-..-.......-SFMFYDH.SFLEMYFLYWITESKISVD---......--.......PPNLDILISYF.K.AKERDSLKELLLDAI-k.................................
A0A6J1WR13_GALME/124-222 .eh--FINPMKKLL.YKLCENIDSEKLHKLKKTLS...TYS-.....--....-..-.......--IDTTMF.ESCELIFLDLMCRKFIEVQQYQyaqkitGN.......EYNIENLAKII.EnFSGLEEFAKQLRDL--ea................................
A0A7M7GZS1_APIME/121-215 ...SRYVNLTAKCL.YLLCETLSEDKIKLLLQYVK...TDII.....--....-..E.......YNVNLKDS.DFLELHMLYWMQENYISINL--......DG.......TVKLENLLKHL.KkIEDLESIYDDLKNHEN..................................
A0A2J7QKG1_9NEOP/168-232 ...SLFVNCMRKAL.YHVCESLDSDGLKKLLRYVK...EDYR....lFQ....K..G.......VELQSFDP.EYMEVNLLYWSSRGYIR-----......--.......-----------.-.----------------..................................
A0A0L0CNR9_LUCCU/130-227 ...SVHIHPLLKAL.YVLAERLTPDQANQLIHYIN...TKY-.....QT....D..T.......QHLRFYDC.SYLEVFLLNWLNKRIIALGDRQ......LK.......GCNIQLLIEYF.K.FNDMAGIKDLLIETIN..................................
A0A6P4HQ37_DROKI/117-218 ...SLHVHPLLKSL.YRICEDLTMAQSGRLILEVS...EKVG....rQQa..gA..G.......DPLRFYDT.SFLEIFLLDWLTRRCIRLGDLN......AT.......GSDVQLLIEHL.K.FNDMQEQAKLLIDTIN..................................
A0A834J573_VESVU/122-223 tkq---LNPIAKCL.YILCESLTEEETKALLHSVK...EDKIflsidKD....K..K.......YEAMLEDI.DQLELHLLYWMNIGYISIFS--......AK.......EGNLKDLLKHL.NaFDDIKQVIRDL-----kcyd..............................
B4R7G3_DROSI/116-182 ...TLHVHPLLKSL.YRMCEELSLAQSGRLFLDVG...EKVA....sQQ....A..G.......DPLRFYDP.AYLEIFLLDWLTKRSIK-----......--.......-----------.-.----------------hh................................
A0A6I9VJ20_BACDO/125-222 ...SVHVHPLLKAL.YRICERLKPAQAGQLVLRVN...EQH-.....KG....P..G.......EHLRFYDF.AYLEIFLLDWLSRRIITLGDRV......AN.......GADVDVLLEFF.K.FNDMDALKTLLLETI-v.................................
A0A2J7QKF2_9NEOP/159-258 ...SLFVNCMRKAL.YHVCESLDSDGLKKLLRYVK...EDYR....lFQ....K..G.......VELQSFDP.EYMEVNLLYWSSRGYISLGDKD......GR.......GVDVHRLKTQL.K.TMGETTLVEKLESAE-k.................................
A0A154NWC5_DUFNO/122-216 ...SRNINLVAKCL.YLLCEELTEDEITLLLQYVK...SDLN.....--....-..K.......YEESLNDI.RYLELHMLYWIQEKYISVY--S......GG.......KANLKNLLKHI.KrFDDLGLIYEDLKG---hdn...............................
A0A8S3WZN8_PARAO/126-224 ...SIYVNPIKKAL.YKLCENINANNLLRLKKTLL...TY--.....--....-..-.......-DIDTSEY.EACELIILQLMCQKFITLSESKiektlsNN.......KCEVEKLIMIV.EnISELKKIALELREIQN..................................
A0A0L7LPH4_OPEBR/140-238 ..n-MHINPMKKAL.YRVCENIDSDNLARLKRTLR...NY--.....--....-..-.......-KIDTMEF.DTCELILLKLMSEKFISMTQIQydkkvlGC.......EFKVDKLVKILeK.LRGLEDLGKEL-----rllqs.............................
B4H2Q9_DROPE/87-183 ..a-LCIIGARQSL.YTICEELSLAQRGRLVLDIK...EK--.....NS....V..G.......DPLRFYDP.EYLEIFLLDWLTRRLIRLGDIN......AN.......GSDVQLLIEYF.K.FNDLHAQATLLVDTVN..................................
A0A0T6AWY1_9SCAR/139-233 ..c-LQVDRIRKHC.FRVCEDFKRTRTKLFLDYLE...DDVEn..lkCM....P..Q.......NEKEMYSM.DYLEMYFLFLEGEKYIS-----......--.......ANNIKNLANIL.K.KMDLLNLHDKFIS---lhe...............................
A0A1W4WH04_AGRPL/181-284 ..h-LFVDPIKKLL.YLLCEHFDSKTTKNFVSYLQ...NKYK.....--....-..-.......DCNIHYSS.ENLEITLLSLLSTKCISLDDMSs....fAQilkelgiEAFYDQLKKFC.K.SNGCEE----------ikplkngtkk........................
A0A6J3KAZ6_9HYME/121-215 ...SRYLNLIAKSL.YLLCEALSEDKIKLLLQYVR...TDLT.....--....-..V.......YEEYLKDV.DFLELHMLYWMQVNYISIYP--......DG.......KVKLENLLKHL.KiFKDLEHIYEDLKKYEN..................................
A0A1S4H7C5_ANOGA/106-199 ...ALHVHPMLKGL.YHFCERLSDENAQKLVIQLQ...QST-.....--....T..F.......APLRH---.ECMEIILLQLLINGNIELGLKQ.....sGV.......ESNVLLLTAAC.K.AAELYDESDFLKSIA-s.................................
A0A5N4AZ53_PHOPY/128-217 ...SLFVDLYKKKL.YCICEKMTNAQMETFLGHVQ...KDF-.....NT....K..K.......LKYMNFPV.PYMEMYLLHWISSKYIS-----......--.......PTDLSNLTKVF.K.VMEMYDACESLKI---kl................................
A0A1W4W5J4_AGRPL/162-265 ..h-LFVDPIKKLL.YLLCEHFDSKTTKNFVSYLQ...NKYK.....--....-..-.......DCNIHYSS.ENLEITLLSLLSTKCISLDDMSs....fAQilkelgiEAFYDQLKKFC.K.SNGCEE----------ikplkngtkk........................
A0A2J7QKF5_9NEOP/168-267 ...SLFVNCMRKAL.YHVCESLDSDGLKKLLRYVK...EDYR....lFQ....K..G.......VELQSFDP.EYMEVNLLYWSSRGYISLGDKD......GR.......GVDVHRLKTQL.K.TMGETTLVEKLESAE-k.................................
A0A836JZP6_9HYME/114-207 ..s-KSINVIAKCL.YKLCESLNESEQKILLSYVK...SEIH.....--....N..Y.......DPLLD-NV.DYLELHMLYWIQIGYITISK--......DK.......MYNMKKLLKHL.K.KFE-------------dghikiismelek.....................
A0A2J7QKE1_9NEOP/168-267 ...SLFVNCMRKAL.YHVCESLDSDGLKKLLRYVK...EDYR....lFQ....K..G.......VELQSFDP.EYMEVNLLYWSSRGYISLGDKD......GR.......GVDVHRLKTQL.K.TMGETTLVEKLESAE-k.................................
A0A1W4W5I4_AGRPL/132-235 ..h-LFVDPIKKLL.YLLCEHFDSKTTKNFVSYLQ...NKYK.....--....-..-.......DCNIHYSS.ENLEITLLSLLSTKCISLDDMSs....fAQilkelgiEAFYDQLKKFC.K.SNGCEE----------ikplkngtkk........................
N6TGN6_DENPD/195-281 ..s-CAVNHKRKVL.YLIAEHLNSGQSSHLMGLMK...KSLA.....-R....A..N.......ITIPDYYR.DYLELSFLQWEYSR--------......--.......-----------.-.----------------mdfgdirnmlkkmgfevfadelesvis.......
A0A310SUV1_9HYME/122-216 ...SRYLNLTAKCL.YILCEALTIDRIKLLLQYVR...ADLT.....--....-..K.......YDENLKDT.DYLELHMLYWMQENYISICL--......DG.......KVKLKNLLKHL.KrFDDLELIYEDLET---nek...............................
A0A833RYR4_9HYME/121-215 ...SRYINLAAKCL.YLLCEALCEDKTKLLLQYIQ...TDLT.....-P....Y..E.......E--NLKNI.DFLELHMLYWMRENYISIYP--......DG.......TAKLKNLLKHL.KtLEDLELICEDLKKR--en................................
A9ZMY8_BOMMO/130-227 ...SMYVDPLRKIL.YKICEEIDTPNLIKLQKSLL...TY--.....--....-..-.......-DIDVSGH.NICEIILLELMSRRFIGIKYCR......HD.......-----------.-.----------------ekylteikidkflriienfdglrklsldlkflqn
F4WNG8_ACREC/216-308 ..s-KSINVIAKCL.YKLCESLNESEQKILLSYVK...SEIH.....--....N..Y.......DPLLD-NV.DYLELHMLYWIQIGYITISK--......DK.......MYNMKKLLKHL.K.KFE-------------dghikiismele......................
A0A821X9B3_9NEOP/118-212 ..c-IHINPLKKIL.YRLCESINTDTLHTLKQTLH...S-F-.....--....-..-.......-DQDITDY.ESCELVFLELMCKKFIL-DRNDl...ckHT.......KVDYQKLTQIL.E.----------------hfpvlssysvyiseles.................
A0A6P4F8C4_DRORH/116-215 ...TLHVHPLLKSL.YRICEQLSLAQSGRLVLDVG...EKVA....rQQ....A..G.......DPLRFYDP.SYLEIFLLDWLTRGCIRLGDIN......AT.......GSDVQLLIEHL.K.FNDLQEHAKLLIDTIN..................................
A0A6J1RW79_FRAOC/121-217 ...SHHVDLVRKTL.FLLLEDLSNEQWNQIMMNLT...TVA-.....SN....N..Q.......ISIPSTCF.EIRECFLVFLMTRKLLQLKTK-......KC.......SMDFVNIRSAL.K.CANLYYWSNQLENLE-n.................................
A0A1I8M1X4_MUSDO/125-223 ...SVHIHPMLKAL.YKICERLSTTQAGRMVMKIN...ERHL.....QR....E..A.......HNLRFYDY.EYLEVFLLFWITRDVISIGNQN......LQ.......GVDVLNLKAYF.K.ENDLDSMKAILDDTIN..................................
A0A158NXZ1_ATTCE/115-208 ..s-KSINVIAKCL.YKLCESLNESEQKLLLNYVK...SEIH.....--....N..Y.......DPLLD-NV.DYLELHMLYWIQIGYITISK--......DK.......MHNMKKLLKHL.K.KFEDGHIKI-------icmelek...........................
A0A4S2L5U4_9HYME/122-215 ...SRSINTVAKCL.YRLCESLNENEQKLLLNNVK...SEN-.....-C....N..Y.......EPL-LDNV.DYLELHMLYWIQIGYITISK--......DK.......LHNMKKLLKHL.K.KFKDGR----------lkiicielek........................
A0A8K0CDA9_9COLE/172-263 ...SLFIDCIKKKL.YRIADSFDNLTTKKFLKIVR...DDF-.....QN....K..R.......LDFKDYGV.QYLEMYFLYWITIKYIF-----......-P.......PHNLKNVCHAF.K.VMERYDITESLEDLV-a.................................
A0A834INZ1_RHYFE/147-232 ...SIVIKKSRKAL.YLLAEKLDHTEIQTLLNSIK...LNVE.....--....T..F.......SDMKSKYN.KYIELFLLNLELNN--------......--.......-----------.-.----------------idickyikgalksmdklelydmlsecf.......
D6WJH5_TRICA/158-248 .ya--YVNKVRKAL.YFVCEALQQKDVENLLNLAC...KDF-.....RE....K..G.......LDFKCINA.QFLELYLLHWETVGYVKLD---......--.......--DLSNLCRVL.K.QIDQLDICDKLREIV-p.................................
A0A6P3X5A5_DINQU/120-213 ..s-KNINIIAKCL.YMICESLDETDQKLLLDNVK...SES-.....-F....N..Y.......EPL-LDNI.NYLELHMLYWMQIKYITIS---......QD.......KCNMKKLLKHL.RnFENLKTICMDLEKF--en................................
A0A084WBG7_ANOSI/107-200 ...ALHVHPILKGL.YQFCERLDDKTSMQLMKQLK...QYVG.....--....-..-.......-N-ASVPQ.DCLEIVLLHLISNDTINLGSRA.....sGK.......ECDLVALTAAC.K.SVELYDESEFLKGIS-q.................................
E1ZVM8_CAMFO/118-186 ..s-KNINIVAKCL.YKLCESLNENEQKQLLSYIK...SD--.....-N....S..N.......YELLLDNI.DYLELHMLYWMQITYITISK--......--.......-----------.-.----------------styli.............................
A0A834MTE2_VESGE/122-222 tkr---LNPIAKCL.YILCESLTVEETKALLHSVK...EDKIflsidKD....K..K.......YEAMLEDI.NQLELHLLYWMNIGYISIFS--......AK.......EGNLKDLLKYL.NaFDDIK-----------piirdlkcy.........................
A0A0M4EZM9_DROBS/115-217 ...TLHIHPLLKAM.YIICEQLTLAQTGRLVLNIN...EKLA....qQQe.hhQ..H.......EPLRFYDS.AYLEIFLLDWLTRHHVRLGDIN......AM.......GSDVQLLIEYF.K.MNDMQAQATLLVETVN..................................
A0A232F6M9_9HYME/126-208 sen---LNKVIKSL.YFVCSNLETKEVSKLITKVN...ERLC.....--....S..P.......VQLDS-NK.LWLEVYILHWLQQNYISINE--......-D.......NPNLNNLIEDL.K.NI--------------gcli..............................
A0A6P8ZG92_DROAB/114-217 ...SLHVHPMLKAL.YVICERLTVAQSGRLVLDIN...EKLA....rQR....N..Egd...igEPLRFYDL.EYLEIFMLDWLTRRHIRLGDIE......TI.......GSDVQLLIEYF.K.FHDMHQFATLLIQTY-n.................................
A0A2J7QKF9_9NEOP/168-267 ...SLFVNCMRKAL.YHVCESLDSDGLKKLLRYVK...EDYR....lFQ....K..G.......VELQSFDP.EYMEVNLLYWSSRGYISLGDKD......GR.......GVDVHRLKTQL.K.TMGETTLVEKLESAE-k.................................
A0A7R8YN34_HERIL/121-213 ...STNIHPILKIL.YKICEVLTPAEAGKLL-SIN...KN--.....--....-..-.......STLRFYDE.SYLEVFFLDWISKDIIAIGDVL.....kKK.......PPNLDELVEYF.K.FNGKIGLYDLTLSA--is................................
A0A6I9WL82_9HYME/117-213 ...SRNINVITKCL.YRLCESLNENEQQWLLNLVK...CEIC.....--....N..Y.......EPLL-DNV.HYLELHMLYWMQIGYITISKSK......--.......IQNTSKLLRHL.E.ECEDSSLKIICM----dlekfnn...........................
A0A194QL32_PAPMA/125-221 ..c-VYINPIKKAL.YKFCENVTANNLVRLKKSLL...TY--.....--....-..-.......-EIDTSEH.ESCELICLELISQKFISLTQNNla..akIK.......QCQVEKLVKIV.EnIPGLKKIAEDLQIIA-n.................................
A0A6L2PW42_COPFO/85-184 ...SLFVSCVRKAL.YHVCESLDSRGLGVLLRLVR...EDYR....hFE....G..G.......GEWEIFDP.EYMELNILYWSDRGYISLGEKN......GR.......GVDVHRLITQL.K.AMGETALVEKLESSV-r.................................
A0A6J0BRU9_NEOLC/117-209 ...SCKINKYAKTF.YNLFENLSKDDAVKLQQRIY...QQID.....--....P..P.......RCSAWMDE.NFLEIHLLWWIKKGLITIS---......GD.......NWELLRILEIL.K.LLNMSSSSAYL-----alqm..............................
A0A6J2XJ59_SITOR/153-233 ..s-ELVNKKRKSL.YLLAEKLNTRETEIFLYNMR...KAFE.....-E....N..H.......EVFQDYDF.DYLELYFLDWEQRT--------......--.......-----------.-.----------------igsnyikrslkimdkehlyei.............
A0A8J2VXE2_9NEOP/127-225 ...SIYIDPMKKVL.YKLCESLNSEIFSKLQKTLI...SY--.....--....-..-.......-NYNVAEY.KTCELILLELISKRFIKLGYYDkekksyTN.......TYDIEELAKIIeK.FSKVNILASVLREIQ-e.................................
E0W1C4_PEDHC/120-216 .ad--SVSNIRKLL.YNICEDLDKEDTRRLIEAMDl.kNEID....yHN....D..D.......DEKGF---.KYLEYKFLLWSKYRVINLNP--......DE.......NINLDALIKVL.K.SINFSNYVPGIEIIV-e.................................
A0A8S4EFK1_PLUXY/180-277 .vc--HISPMKIAL.YRLCEEMNSDNLNRFKKTLL...SY--.....--....-..-.......-NIDVSQH.ETTELVLLELLCCRFISIAKINdl.rqlDN.......ECEMDKLVKII.EnCPGLLSCAQKIKE---aer...............................
B4JNA9_DROGR/115-215 ...ALHIHPLLKAM.YHICEQLTITQSGRLILDLN...EKLTr...hKQ....N..N.......EPLHFYDA.DYLEIFLLDWLTHRHLRLGDIN......AV.......GSDVQLLIEYF.K.FNDLKSLATLLIETVN..................................
A0A6J2TRC5_DROLE/114-223 ...TLHVHPLLKAL.YIVCEQLTLAQSSRLVLSISdmqTRIN....aQQ....Q..GpesasanDRLLIYDF.AYLEIFLLHWLTRRIIKLGDIN......AE.......GSDMQILIEYF.K.FNNLESLSSLLIQTIN..................................
A0A653BKU8_CALMS/160-252 ...TVYVNKLRKML.YIICEKLDSSKTEVLLEYVR...KDYM....hKS....M..E.......LNEFNMDP.IALELYLLYWESCDYIK-----......--.......QTNVENLMKAF.K.VMEEEQLYNILDSYH-k.................................
A0A835CWB2_9HYME/123-216 .vi--KIHTATKIM.YKLFELLNEQQSQLLCKLIY...KDI-.....--....-..-.......PVIKFNQN.DILESHAFYWLSKKYITISS--......DG.......SCDLSKIHKHM.K.TIGL------------fdtpiyhdmekyvk....................
A0A151WV87_9HYME/115-208 ..s-KSINVIAKCL.YKLCESLNESEQKLLLNYVK...SEIH.....--....-..N.......YEPLLDNV.DYLELHMLYWIQIGYITISK--......DK.......MHNMKKLLKHL.K.KFEDGHIKIIC-----memek.............................
A0A8J6HK89_TENMO/105-194 ..f-LYVNKSRKAL.YFLCELFLPHEVEALVSLAS...SDMA.....-R....K..N.......VPFKRF-N.SYLELYFLDWEVSGYIK-----......--.......QNNWNNLYVIL.K.QMEEFDRCDNLKEIV-p.................................
A0A067QV28_ZOONE/69-167 ...SLFVNCVRKAL.YHVCESLDSEGLNELLRRIK...EDYR.....CL....H..G.......VELETFDP.QYMEVNILCWSSRGYISLGDKD......GC.......GVNVHRLKSAL.K.AMGETGLVEKLESAV-k.................................
A0A182H1W5_AEDAL/112-205 ...ATHVHPVLKGL.LLLCEKMDRATGGRLVDYLK...QNC-.....--....-..-.......-ASTVTDS.EYLEMVMLELIEQGRIKLGSKQ.....sSQ.......ACDLSNLIAAF.K.GMELEALKDFCKSIE-s.................................
E2BE23_HARSA/105-159 ..s-KNINIIAKCL.YVICESLDEVNRELLLDHIK...SEN-.....--....S..N.......YESLLDNI.NYLELHMLYWM-----------......--.......-----------.-.----------------..................................
A0A026WDB3_OOCBI/101-194 ..a-QNVNVIAKCL.YDVCESLDEDEQNLLIRFVK...SEN-.....-S....N..Y.......EPLL-DNV.DCLELHMLYWMQIKYITISK--......DR.......EHLIRLLKHLA.S.FANLQTICWDLE----kfdn..............................
A0A2A4KAV9_HELVI/130-228 ..k-MYVNPMKKAL.YKLCESINSDNLLKLKKALL...TY--.....--....-..-.......-DLDTTEY.ESCELVFLKLMCEKFIIINQYQ......YNskv.lgfKVNVDKLIKIV.E.----------------nlpglkklaleinmlqh.................
A0A6I8WCV0_DROPS/119-215 ..r-VHIHPLLKSL.YTICEELTLAQRGRMVLDIK...EK--.....NS....V..G.......DPLRFYDA.EYLEIFLLDWLTRRLIRLGDFN......AN.......GSDVQLLIEYF.K.FNDLHAQATLLVDTVN..................................
B4M7Y9_DROVI/112-215 ...SLHVHPLLKAL.YNICEQLTIAQTGRLVLDIN...DQLA....rRQagrhA..D.......EPLRFYDH.AYLEIFLLDWLTRHHLRLGDIN......AR.......GSDMQLLIEYF.K.FNDMHSLATLLVQTIN..................................
A0A6J1RUQ9_FRAOC/121-217 ...SHHVDLVRKTL.FLLLEDLSNEQWNQIMMNLT...TVA-.....SN....N..Q.......ISIPSTCF.EIRECFLVFLMTRKLLQLKTK-......KC.......SMDFVNIRSAL.K.CANLYYWSNQLENLE-n.................................
A0A8K0P339_LADFU/1-80 ...-----------.----EDLHPKTSQKLVQRVE...SER-.....-P....D..L.......ARHFLPDA.RLLEVTILHWASRGYIKII--Q......EN.......SMDVRNIIRHL.S.EMGELKMAEFLEKY--lp................................
A0A2A3E9L8_APICC/72-166 ...SRYVNLTAKCL.YLLCESLSEDKIKLLLQYVK...TDII.....--....-..E.......YKVNLKDS.DFLELHMLYWMQENYISINL--......DG.......TVKLENLLKHL.KkIEDLESIYDDLKNHEN..................................
A0A195B8D0_9HYME/114-207 ..s-KSINVIAKCL.YKLCESLNESEQKLLLNYVK...SEIH.....--....N..Y.......DPLLD-NV.DYLELHMLYWIQIGYITISK--......DK.......MHNMKKLLKHL.K.KFEDGHIKI-------icmelek...........................
A0A195FXN4_9HYME/126-219 ..s-KSINVIAKCL.YKLCESLNESEQKLLLNYVK...SEIH.....--....N..Y.......DPLLD-NV.DYLELHMLYWIQIGYITISK--......DK.......MHNMKKLLKHL.K.KFEDGHIKL-------icmelek...........................
A0A8J2MM11_COTCN/130-211 .gk---INVGNKIL.FKFFESLSEKESENVLKKIY...SDI-.....--....-..C.......LDRRLSDI.NLMEIHALYWLSIGFIKITPTD......--.......-GDLGNLLKYL.K.P---------------lgyfdt............................
A0A8B8ICL6_VANTA/126-224 ...TVYIDPVKKAL.YKICENMTLEHLSKFKRTLI...SY--.....--....-..-.......-KINISEH.DMCEIIFLELMSQKFILLGQYD......KEtkk.yngNYDIEELAVIF.DnLSHFGKYATILREIK-n.................................
#=GC seq_cons ....halssltKsL.YplCEsLspsptppLlptlp...pch........................slphhsh.-aLElahL.WhsppaIplsp........sp.......tsslppLlchl.K.h.shtthhp.l.......................................
//
