GenomeNet

Database: Pfam
Entry: DrrA_P4M
LinkDB: DrrA_P4M
Original site: DrrA_P4M 
#=GF ID   DrrA_P4M
#=GF AC   PF14860.9
#=GF DE   DrrA phosphatidylinositol 4-phosphate binding domain
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   Jackhmmer:Q29ST3
#=GF GA   26.20 26.20;
#=GF TC   26.20 26.80;
#=GF NC   25.20 24.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   20176951
#=GF RT   Structural mechanism of host Rab1 activation by the bifunctional
#=GF RT   Legionella type  IV effector SidM/DrrA.
#=GF RA   Zhu Y, Hu L, Zhou Y, Yao Q, Liu L, Shao F;
#=GF RL   Proc Natl Acad Sci U S A. 2010;107:4699-4704.
#=GF RN   [2]
#=GF RM   20616805
#=GF RT   High-affinity binding of phosphatidylinositol 4-phosphate by
#=GF RT   Legionella pneumophila DrrA.
#=GF RA   Schoebel S, Blankenfeldt W, Goody RS, Itzen A;
#=GF RL   EMBO Rep. 2010;11:598-604.
#=GF DR   INTERPRO; IPR028057;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain binds to phosphatidylinositol 4-phosphate. It is
#=GF CC   found in Legionella pneumophila DrrA, a protein involved in the
#=GF CC   redirection of endoplasmic reticulum-derived vesicles to the
#=GF CC   Legionella-containing vacuoles [1,2].
#=GF SQ   35
#=GS A0A0W0ZNX1_9GAMM/384-497    AC A0A0W0ZNX1.1
#=GS A0A0W0XW72_9GAMM/494-595    AC A0A0W0XW72.1
#=GS A0A6F8T857_9GAMM/129-236    AC A0A6F8T857.1
#=GS Q5ZSB6_LEGPH/326-430        AC Q5ZSB6.1
#=GS A0A0W1AIZ4_9GAMM/1-56       AC A0A0W1AIZ4.1
#=GS A0A0W0TS70_9GAMM/23-120     AC A0A0W0TS70.1
#=GS A0A0W0XQN7_9GAMM/296-401    AC A0A0W0XQN7.1
#=GS A0A0W1A4Q3_9GAMM/340-425    AC A0A0W1A4Q3.1
#=GS A0A0W0TLF4_9GAMM/506-587    AC A0A0W0TLF4.1
#=GS A0A098G3D5_9GAMM/338-447    AC A0A098G3D5.1
#=GS A0A098G693_9GAMM/596-706    AC A0A098G693.1
#=GS A0A433JGK0_9GAMM/1925-2023  AC A0A433JGK0.1
#=GS A0A0W1AC27_9GAMM/52-156     AC A0A0W1AC27.1
#=GS A0A0W0Y666_9GAMM/507-611    AC A0A0W0Y666.1
#=GS A0A0W1ABC9_9GAMM/54-151     AC A0A0W1ABC9.1
#=GS A0A078KTJ3_9GAMM/1013-1105  AC A0A078KTJ3.1
#=GS G9EKK5_9GAMM/1-86           AC G9EKK5.1
#=GS A0A0W0V8A7_9GAMM/495-606    AC A0A0W0V8A7.1
#=GS A0A0W1AD05_9GAMM/295-407    AC A0A0W1AD05.1
#=GS A0A078L2I8_9GAMM/474-517    AC A0A078L2I8.1
#=GS A0A0W0WH13_9GAMM/294-402    AC A0A0W0WH13.1
#=GS A0A378LY42_9GAMM/744-857    AC A0A378LY42.1
#=GS A0A0W1A7G5_9GAMM/810-875    AC A0A0W1A7G5.1
#=GS G9ERP3_9GAMM/462-566        AC G9ERP3.1
#=GS G9EMR5_9GAMM/194-296        AC G9EMR5.1
#=GS A0A0W1ACG7_9GAMM/220-310    AC A0A0W1ACG7.1
#=GS DRRA_LEGPH/538-640          AC Q5ZSQ3.1
#=GS DRRA_LEGPH/538-640          DR PDB; 4MXP A; 538-640;
#=GS DRRA_LEGPH/538-640          DR PDB; 3L0M B; 538-638;
#=GS DRRA_LEGPH/538-640          DR PDB; 3L0M A; 538-640;
#=GS DRRA_LEGPH/538-640          DR PDB; 3N6O B; 538-637;
#=GS DRRA_LEGPH/538-640          DR PDB; 3N6O A; 538-639;
#=GS A0A0W1AGC3_9GAMM/294-399    AC A0A0W1AGC3.1
#=GS A0A078L153_9GAMM/223-328    AC A0A078L153.1
#=GS A0A0W0XXU0_9GAMM/147-250    AC A0A0W0XXU0.1
#=GS A0A0W0YVQ3_9GAMM/360-464    AC A0A0W0YVQ3.1
#=GS Q5ZWI4_LEGPH/213-318        AC Q5ZWI4.1
#=GS A0A378M2J1_9GAMM/112-217    AC A0A378M2J1.1
#=GS A0A0W0TZ20_9GAMM/180-262    AC A0A0W0TZ20.1
#=GS G9EKI0_9GAMM/1-49           AC G9EKI0.1
A0A0W0ZNX1_9GAMM/384-497               ..................e-KPR.KHDYEVt.....tEtVVNASQEFKSRYQNMKGDELKTHILLNFKSKIEQ....FK.TTEEIQEYLKA..FKDTNEYK..TLEIGQGAFTRVahkLG.LKkwitTDSVDAIDKIVKDTMKKIEEK-g.................
A0A0W0XW72_9GAMM/494-595               ..................y-TNR.HHFWPA.......-.-----TIAKGQFANLRGDPLKQAILADFKRQIEA....CT.SDNGLKQCSSR..LRESSEFQ..VLTMAQDRFTYF...FR.WLpwvkTSSEKAFEKMLNDQGSYLSL--sk................
A0A6F8T857_9GAMM/129-236               ..................a-KDR.IHLFKAtl...nsN.KNQNCTFLNEEEKKLTGDALKGKILDKFKNELES....SV.GPEKFKEVVAK..ITASPEYQ..IIKTSQGLASKI...LG.LE....TDSHKTLRDMISQRKTELN---ige...............
Q5ZSB6_LEGPH/326-430                   ..................k-KFK.KHSHEV.......GvNRFFSPKKQEIYEGLKGDGLKKVILKELRDSLAE....IR.TMEQLEEKKLE..FLASPEMQ..ILAEGQDKTTKA...LN.LK....TSSRKKVMVIFKEAEERILNS-p.................
A0A0W1AIZ4_9GAMM/1-56                  ..................d----.------.......-.----------------------------------....--.--EAVRSFKKE..SKEITEYQ..VLCASQGITSHL...FG.LK....TSSLKALEQIIADAYK------lakerq............
A0A0W0TS70_9GAMM/23-120                .........vaytdlkpgf----.------.......-.-------YQNECQGLFGVDLKRKILEIAVTELLE....AQgDRKKIGETLDA..LCDSGALA..ILEKGQGFTSRM...FPcIK....TSAAKSLKSILDEISNPLK---sme...............
A0A0W0XQN7_9GAMM/296-401               ..................r-KNR.LHFFHE......vSvNDASHDRFKNQYKGIKGDALKRAILNGLKDELAE....AE.TEEALLDIITR..FLKSPEMA..ILDKAQGKLTHS...FN.LK....TDSHKAAEKLFEAAKKRIND--aa................
A0A0W1A4Q3_9GAMM/340-425               ...........svklikqe----.------.......-.---------------KRNPSKHSILKNLQQKLAE....ID.SLDELYRHRIA..FKKGEDYK..LLLKNQHSIYNL...FG.RS....INFKKEVKQLYHQAASRILDN-e.................
A0A0W0TLF4_9GAMM/506-587               ........ytsgceglrdv----.------.......-.------------------ALKRKILEMVTEALLR....AE.NREGYNKVLDT..LESSGALG..ILRTGQGFYSRM...FN.AQ....TSPMAALEAIKAEVS-------kdk...............
A0A098G3D5_9GAMM/338-447               ...hkkrtvdlsnvsfqkp----.------.......E.SSEEFKNFKSKYGNLKGDHLKTKILEDFRQQIEE....TT.SKKELADLKTK..IEASYEYD..VLKKAQGWFTGK...VG.IK....TSSEKALADMFKQQEKFLSN--td................
A0A098G693_9GAMM/596-706               ..................n-THY.EHATHIt.....eNnRWYFCQASSDKFRDLKGDCLKTRLLLDFKSELTTyaqmCT.SKEQFDKHVEE..LKQSKEYE..VLATGQGQVTKI...FG.LE....TSSVKAFNNIAAELRDGIDD--ls................
A0A433JGK0_9GAMM/1925-2023             ....prnhryivevdhlpe----.------.......-.---------------KGDQLKGKILKNLRKALNLaiadSS.SLQELDSEITR..IKKDYEFElnTLKTAQDITTWL...FG.LR....TDSFKAFEKMCKDAREI-----vikna.............
A0A0W1AC27_9GAMM/52-156                .................ai--GR.PHVFGD.......-.TAKGFKDIKAELAHLKGEQLKREILFDFKKEVDK....LT.TLEELTSFEQRtiIQKSHAYQ..ILEKQQGFLSRL...SS.TE....TDSVKALKKMVHEKREALRF--es................
A0A0W0Y666_9GAMM/507-611               ..................n-SGR.LHLYNK.......AaVAEGMNLVKAELQGLRGDALKRGILDAYKEKIAA....CG.TKEELEDLRKA..YDQSDDKK..IIESSQGLMSSI...RK.LE....TSSQKEMKAMFESADERVKEF-e.................
A0A0W1ABC9_9GAMM/54-151                ..................d-KGR.THLWEA.......-.-----KSFKQQYHALKGDALKTTILNDFKSKIVN....CS.SRQELEDAVEN..IRASNDFK..ILAQAQGLVTHH...FN.LK....TSSVEALERIIEDKFTELRSS-s.................
A0A078KTJ3_9GAMM/1013-1105             .................gh--SR.LHLAPA.......-.-----KSNDPKYEHLKGDVLKRKILLDFKHKLES....CS.NEDDLRAVISE..IKGSKEYA..ILDKAQTWQA--...--.PT....PDAKNALENMIADSELE-----lgis..............
G9EKK5_9GAMM/1-86                      ...............mssa----.------.......-.-----------EHGLKGDLLKTKILLDFRISLMN....IT.DLEHFDLVIKR..FEQSKDYT..ILKTGQGLITRF...FN.LE....TSSVRAVKEIIAEVRQEIQQK-p.................
A0A0W0V8A7_9GAMM/495-606               ..................g-NSR.KHASPVsldnlevKgDFHKVHDLKAKYKGVMGDALKTSILLDFKTQLEN....CN.TREDLEKKITE..IEASPAYH..VLKKGQGITTQL...LR.LK....TSSIDALEKLIKTRRDELPD--tg................
A0A0W1AD05_9GAMM/295-407               .................tv--NR.VHTFHEas..aedLgYADDFKKIKEEFMGIKGDALKRVIIKELKDSLES....ID.TLEDLARRKLS..FYDSPKMK..ILDIAQGKTTSIlgpLG.LK....TSSHDAVAQLFKDAEKRIQNQE..................
A0A078L2I8_9GAMM/474-517               ..................g-KSR.SHLIPV.......-.IPVKYQGPKRQYYGLVGDNLKRAILDDFKDSLEE....--.-----------..--------..------------...--.--....----------------------..................
A0A0W0WH13_9GAMM/294-402               ...................KEDR.KHTFHE......vSaEDFKSQEYKQEYRGIRGDALKRTILKELKDALED....VK.TEEELEEIKSN..FFKSPEMK..IIDKPQGRATRMlghFG.LK....TDAHKAAEEIFKKAEEKISKF-s.................
A0A378LY42_9GAMM/744-857               tryehfatsnqenrevatm----.-----A.......T.CADLNQSFKERYKQCQGDHLKSTILKDFYEDLEN....AE.TEREVDDVVNR..YKKDGRYD..ILAKAQNNTMQV...LG.MT....TTSAKAFESLITERMESINAQ-k.................
A0A0W1A7G5_9GAMM/810-875               ...................KNCR.FHLFAA.......-.--KIDAQKYPKYQEKKGDVLKTEILKNFKKSLEG....-K.NKTEI------..--------..------------...--.--....----------------------xxxxklthknirsikrkk
G9ERP3_9GAMM/462-566                   ..............kpfyt----.-HASNT.......QsRFHMFGANSQQYRAFHGDLLKTKILSIFKEKLQS....CS.SPIELQNKVLE..IKNCDEYR..ILAQGQGLITRG...LG.LE....TSSIKALNKMIEDIGRSLSDS-p.................
G9EMR5_9GAMM/194-296                   .................ag--GR.FHAYKV.......-.SGTKFAGLPEHLQKFKGDHLKSQILLDFKMQLMD....AK.THQEVDDLVTE..FQKKVEYD..VLTTGQGFISLR...FH.RP....TSSLRAFEHMVNERKQDISTE-k.................
A0A0W1ACG7_9GAMM/220-310               ...........pgrdhgey----.------.......-.-----TATSENYKGLQGDALKTKILSDFRDAIAG....-K.SAKEIQNIYDD..FKTKPEYT..ILATGQGWATRF...FH.WK....TSSIIALNAIKEEAA-------aen...............
DRRA_LEGPH/538-640                     ..................d-EGR.EHRYTA.......-.STENFKNVKEKYQQMRGDALKTEILADFKDKLAE....AT.DEQSLKQIVAE..LKSKDEYR..ILAKGQGLTTQL...LG.LK....TSSVSSFEKMVEETRESIKSQE..................
#=GR DRRA_LEGPH/538-640          SS    ..................S---S.--TT--.......-.-STT-TTS-GGGTT--HHHHHHHHHHHHHHHHTT....--.SHHHHHHHHHH..HHTSHHHH..HHHS-SSHHHHH...HT.--....-HHHHHHHHHHHHHHHTTCCHH..................
A0A0W1AGC3_9GAMM/294-399               ..................r-ESR.AHTFHE......vSsDDFQSPSFKKQYQSIKGDALKRTILRELKYSLDQ....MD.NLEELQQLKHQ..FLRSPEMQ..ILDKAQGQWTSR...FH.LK....TDSHKAVERLFASAEKRIKEE-i.................
A0A078L153_9GAMM/223-328               .................kd--SRwYHAFKA.......T.TKDTSQAFKDKHKDQIGDHLKNSILEDFRKQIED....APfDLPEFKTFVTT..LRNTEGYA..ILKTGQGCLTTF...FD.WE....TSSVAAFNEMVAEKIKQIGQ--ie................
A0A0W0XXU0_9GAMM/147-250               ..................e-ANR.THLFKAt....lnLsKTQNCFFLDNEEKKLTGDALKGKILEKFRIELEN....CI.TSDDFKDTVNR..IRGSEEYQ..IIKKSQGLGFRE...--.--....TDSHKALRSMISQRGSDLNV--pe................
A0A0W0YVQ3_9GAMM/360-464               ..................s-TGR.AHRYSV.......-.SAETMKTIKQEFQQLKGDHLKREILLDFKSQIEN....IS.TIEELQKFETEniKNKSESYK..ILATSQDLTTRI...LH.LE....TDSVKALKHMINEKRVVLNT--dl................
Q5ZWI4_LEGPH/213-318                   .................ig--SR.FHLFTA......kVdEKTGDQSFKDRYSQVKGDILKRAIINNLKNDIEK....ID.NLDDLKDFIKK..FKQSSEYM..TLSKAQGLFTKV...TG.IK....TDSQRAVEEIFSKALKDLQSP-k.................
A0A378M2J1_9GAMM/112-217               ..........hyehatyvk--GR.IHALNI.......-.---DRSKLSPELRKLSGDALKTAILLKVKNDLDK....LT.EPQAIEKYKSD..FLDKPEYD..VLKSAQGLVTYF...FK.RD....TSSITAFNLLIAEAIKN-----cttp..............
A0A0W0TZ20_9GAMM/180-262               ........epytsgckglr----.------.......-.----------------DVALKRKILEILAEALLR....AE.TPEQYQEALSK..LDSSGAVS..ILTTGMGFSSRI...FQ.LQ....TSSSDALTAIEEE---------vwek..............
G9EKI0_9GAMM/1-49                      ..................m----.------.......-.----------------------------------....--.---------QE..LKSKPEYK..ILEKGQGIATKV...FG.LE....TSSVKAFNKMVDEQGKNLSKKE..................
#=GC SS_cons                           ..................S---S.--TT--.......-.-STT-TTS-GGGTT--HHHHHHHHHHHHHHHHTT....--.SHHHHHHHHHH..HHTSHHHH..HHHS-SSHHHHH...HT.--....-HHHHHHHHHHHHHHHTTCCHH..................
#=GC seq_cons                          ..................t..sR..Hhh................pthpppaptl+GDsLKppILpcaKppLpp....hp.ohc-lpchhpc..hcpSs-Yp..ILppuQGhhTph...hs.lc....ToSh+Alcphhp-ttpplpt....................
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