GenomeNet

Database: Pfam
Entry: Dsl1_N
LinkDB: Dsl1_N
Original site: Dsl1_N 
#=GF ID   Dsl1_N
#=GF AC   PF11988.11
#=GF DE   Retrograde transport protein Dsl1 N terminal
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_3etu
#=GF GA   25.00 25.00;
#=GF TC   35.60 28.90;
#=GF NC   22.80 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0295
#=GF RN   [1]
#=GF RM   19151722
#=GF RT   Structural characterization of Tip20p and Dsl1p, subunits of the
#=GF RT   Dsl1p vesicle tethering complex.
#=GF RA   Tripathi A, Ren Y, Jeffrey PD, Hughson FM;
#=GF RL   Nat Struct Mol Biol. 2009;16:114-123.
#=GF RN   [2]
#=GF RM   11493604
#=GF RT   The coatomer-interacting protein Dsl1p is required for
#=GF RT   Golgi-to-endoplasmic reticulum retrieval in yeast. 
#=GF RA   Andag U, Neumann T, Schmitt HD; 
#=GF RL   J Biol Chem 2001;276:39150-39160.
#=GF DR   INTERPRO; IPR021875;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Dsl1 is a peripheral membrane protein required for transport
#=GF CC   between the Golgi and the endoplasmic reticulum [1]. It is
#=GF CC   localised to the ER membrane, and in vitro it specifically binds
#=GF CC   to coatomer, the major component of the protein coat of COPI
#=GF CC   vesicles [2]. It is comprised primarily of alpha helical bundles
#=GF CC   [1]. It complexes with another subunit of the Dsl1p complex
#=GF CC   called Tip20 which forms heterodimers by pairing the N termini
#=GF CC   of each protein [1].  A central disorganised region between the
#=GF CC   N and C termini of Dsl1 contains binding sites for coatomer [1].
#=GF CC   The C terminus of Dsl1 contains a binding site to the Sec39
#=GF CC   subunit of the Dsl1p complex [1].
#=GF SQ   30
#=GS DSL1_YEAST/5-360         AC P53847.1
#=GS DSL1_YEAST/5-360         DR PDB; 3ETU A; 37-355;
#=GS DSL1_YEAST/5-360         DR PDB; 3ETV A; 54-350;
#=GS A0A1U7EQB3_9SACH/20-370  AC A0A1U7EQB3.1
#=GS Q6CUS2_KLULA/12-352      AC Q6CUS2.1
#=GS Q6CUS2_KLULA/12-352      DR PDB; 6WC4 C; 333-352;
#=GS Q6CUS2_KLULA/12-352      DR PDB; 3K8P C; 333-352;
#=GS G0V593_NAUCC/12-369      AC G0V593.1
#=GS K0KHW4_WICCF/10-178      AC K0KHW4.1
#=GS A0A1X7R2M1_9SACH/5-355   AC A0A1X7R2M1.1
#=GS J7S867_KAZNA/6-376       AC J7S867.1
#=GS G8BQ21_TETPH/10-363      AC G8BQ21.1
#=GS A0A7H9AV59_ZYGMR/16-366  AC A0A7H9AV59.1
#=GS A0A1G4MGQ1_LACFM/21-362  AC A0A1G4MGQ1.1
#=GS J8Q396_SACAR/5-358       AC J8Q396.1
#=GS A0A1E3P269_WICAA/24-196  AC A0A1E3P269.1
#=GS A0A1E4RZ31_CYBJN/19-176  AC A0A1E4RZ31.1
#=GS A0A1E5RGU1_9ASCO/23-407  AC A0A1E5RGU1.1
#=GS A0A1G4JZV3_9SACH/23-369  AC A0A1G4JZV3.1
#=GS G8ZQK5_TORDC/17-366      AC G8ZQK5.1
#=GS A0A1G4JWI2_9SACH/21-364  AC A0A1G4JWI2.1
#=GS Q6FNZ0_CANGA/3-351       AC Q6FNZ0.1
#=GS C5DYW5_ZYGRC/12-364      AC C5DYW5.1
#=GS Q752C3_ASHGO/45-390      AC Q752C3.1
#=GS A7TF57_VANPO/11-362      AC A7TF57.1
#=GS I2GW53_TETBL/22-390      AC I2GW53.1
#=GS A0A376B2R6_9ASCO/21-405  AC A0A376B2R6.1
#=GS A0A1V2L1Q6_CYBFA/15-195  AC A0A1V2L1Q6.1
#=GS A0A7H9HNE0_9SACH/16-365  AC A0A7H9HNE0.1
#=GS G0WD68_NAUDC/10-396      AC G0WD68.1
#=GS H2AUI4_KAZAF/5-354       AC H2AUI4.1
#=GS C5DK93_LACTC/23-365      AC C5DK93.1
#=GS A0A1S7HMD7_9SACH/12-362  AC A0A1S7HMD7.1
#=GS A0A0C7N2K0_9SACH/24-368  AC A0A0C7N2K0.1
DSL1_YEAST/5-360                    .....................f-PNKGEIIRELLKD....PLI...LKNDSKRSn............gSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMR......NNAAYLKQ.SFNFQQSISTYVDTLHLELVSTLYKILTNGFWKI........T.ENSIQFTPTV...EWGKDKVHIEYDTFMDFVAQQYF..............PKGSL..DNQAWFILDM.TSAD.SQEQVRAKLNTIMKEYMNLSRIVSM.IKNSIFISGKEISYENEKNI...lVFSKSS........SHGQHCVSTVLTSFEAVCDFMLDGLAFR.DRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPL.KNLVSVINNKLTRLVAK.........sEVTNWTH...SGKEIQDLLMNKQLYYNLLLDKVLESHISEIR.....................
#=GR DSL1_YEAST/5-360         SS    .....................X-XXXXXXXXXXXXX....XXX...XXXXXXXXX............XXXXXXXHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH......H-CCHHCS.-HHHHHHHHHHHHHHHHHHHHHHHHHHHCTTEEE........-.SSEEEE-SEE...EETTTTEEEEHHHHHHHHHHHH-..............CCCS-..-TTSHHHHT-.SSHH.HHHHHHHHHHHHHHHHTS-HHHHHH.HHCCTT-TTEEEEEETTTTE...EEEEE--........------HHHHHHHHHHHHHHHHHTS-HH.HHHHHHHHHHHHHHHHHHHHHHHTHHHHTSSTT-CH.HHHHHHHHHHHHHHHHH.........HT-SS---...-SHHHHHHCHXHHHHHHHHHHHHHHHXXXXXX.....................
A0A1U7EQB3_9SACH/20-370             ....................ll--NKENVLASLKDD....PLL...TGAQDEETn............kDPATLDYDAILRKESCLNQQLHDLSSLRSVSGLIMEFKANFELLEFENCYYSLQSLRKKLR......DNAAINKQ.GVSFQQSVLAHADAMHSQLVHKFYEIITQHFWQV........T.DESIAFEPIV...GLGDDSEDLDYVPFMSFIEQQFY..............SDGFL..DANLWIIGDM.RAGP.TQDEVIFELNAIFHDYLNSRMIIEV.IKKFLFSKAKQIVFERGSC-....VKLKLH........RDGEDKVSDRIANINSVACFLCEGISVR.DIDTFAKKLGPVLATELIQTVKSNPYTVLHSSHSQI.RADVAMANQNLRKLAKK..........--SNWTY...HGSDVESLLNDNQVQNRLLLDGIFEQYALKIR.....................
Q6CUS2_KLULA/12-352                 ......................LSDTSALSQAIEAD....PQF...KSSDSVHP..............KPNSKLLEEVLREDSDLTKDLAKYNQYKILSDLLKEFNTNYELNELENCYYSLQNIHKKFK......-DVNISGE.SFRFQQSVATYIDCLHLNVLERFKEV-SNMFYTI........S.GNEMMFKKTI...--ELDSVEFNFDEMVELFENNFF..............DHNMI..DQTHWFIAST.NLET.YKDKEIVLLQEILDDTVKLNPLIKF.FKEFVFDEKCIMVRAE----....PGKLTL........ATSEYNSLDQIKSYQTLTTFIENDLSKH.AKESVMIHFGNVLLTELLKIIRANPELLSNDKEQT-.TEIISSIHDSLTKISEE..........--TEWAY...DGFELNRILKDENIYTTLKFESMMQQRVIQIR.....................
#=GR Q6CUS2_KLULA/12-352      SS    ......................XXXXXXXXXXXXXX....XXX...XXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......-XXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX........X.XXXXXXXXXX...--XXXXXXXXXXXXXXXXXXXXX..............XXXXX..XXXXXXXXXX.XXXX.XXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXX----....XXXXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-.XXXXXXXXXXXXXXXXX..........--XXXXX...XXXXXXXXXXXX--HHHHHHHHHHHHHHHHHH.....................
G0V593_NAUCC/12-369                 ......................LGNRDALIQSIEQNletpPLT...ATHDGNSS..............-TQELNRGQLMMKEEQLSSQLHDLNNLKILSGLLIEFKTNFELLELENCFYSLQSIRKRINg....nNNSSFLKQ.SFHFQRSVAVYVDTMHSTLIDKIFEIITTKFWQI........NdTGSIAFHKKI...TYGPEDIDLEYESFIDFVKQQYF..............PQNVL..DSQLWIISDM.DIND.LQENVRGKLQTILKSYIHLNVVIDR.IKKSIFTKGKMFDYELGKLL...fKDVSNI........TDNQSLLQETIASFTSLVRFFQDILIED.DCITVLTSLGNVISNELTKLVKQNASVILND-NSPL.KDRIIEVSKSLVKLADR..........TKNQWHF...NDSEILNILNNEQIYFNLMLDKKFNEALEYMR.....................
K0KHW4_WICCF/10-178                 .........qleslnekihqlv-------------D....PEV...LNSQLNGS.............kTLDFNTISKLQQRDYEITQELQQLREFWIVSTLLKETEVNLDLFEFENVLYSLKNFEKKIK......-SDSFDTK.LIILEKLQAEH-DRLYNLTIENIGTSWSK-LIEV........Q.ESSVTFNAEV...--DINGNTVLYESVSDVIKSN--..............-----..----------.----.-------------------------.--------------------....------........----------------------------.------------------------------------.-----------------..........-------...--------------------------------dlqlkvpnsniih........
A0A1X7R2M1_9SACH/5-355              ....................ii--EENRIITSIAND....PIF...AKDDVDTR..............-SSNLDVNHILETESQLSSQLHDLKNLKVLASLIKEFNTNLELLELENCYYSLQNLRKKLK.....eNNEAFIKQ.SFHFQKSVVTYVDSLHVEFINKLYDIFSQGFWNI........T.DDSIRFRSSI...EWGDENFLLEHDLLLDLVKQLFC..............PGDTL..DLHSWIIDDM.EFGN.DRDTVRTKIEDLHKNYILLNSLINP.IKDKIFSKNALIKYTKKDD-....TIKFIV........SESKPSVPMLFDCFQALCDFSLNTIPQS.LLPILLKSIGKVLENELLKCVKNNAGEIIGRDNKDL.KEHASKINDLFSTLSSK..........SQGNWSY...HAHTIKDLLQDRQLYINLLVDEIYHRAVRDIR.....................
J7S867_KAZNA/6-376                  .....................a-PEREEVLLSVERD....PIF...QGENGADVaa.........snyTQLTERIREVVAQEAQLGSMLHDLSVLKTFGDLLNEFNTNLAKSLFQDCYRALQTLRQKLN.....tSRDCFVKQ.PLHFQRSLMNYIDELHLTLIERIYEIISTDFWSV........T.HDSITFHNKI..vCSEGSGGQFEYRQFMELVKKLFFw............dDGEIS..TEDTWFLKDM.DLNNpSSNIVRNKLSEISKNYLELNEIVVN.LKRGIFDNSIKFEFQAESCT...lSFTKVKnaipnssgSYNKAALASVVESINALADFLMQCIDGN.DLVIILSKLGPLLSNELLNFLRKNATVILRDSDPSI.REGIVLINNRFGVLASK..........SNGFWNH...NRNDIEHLLNDKQLYINLLVDDAFAKTFKEIR.....................
G8BQ21_TETPH/10-363                 ....................vl--NEQSIKESLLQD....PLL...FRNKSGDSvd..........snSNELLSFESVMNKDTALVAELHDLNSLKQISDLILEFNANWEYIEVENCYYSLLNLRKKLK.....qNDTVLAKQ.NIRFQQSVITYVESLHLKLIEKVSDLLTEKFWNI........T.SNSVVYNASV...--ELNNVKFEYKPFLEFLSNELIi............eNDNIL..DLNNWFIKDM.SLGE.LHNMVRNKMKIILNDYLHFELLLNK.LKEALFNSNMKFDYDVNNR-....KLSWEE........NYHDVKSKDKLESLTNIVNYMNTELSEL.NSK-LIEKLSPLVANEFTKLVKGNISEIVQNENL--.STTVLTLNESINNLKSF.........tQTASWYF...DTAVINDLLKSKEVYNNLILDQILESHLEQLR.....................
A0A7H9AV59_ZYGMR/16-366             ......................LGDNDKLLRELKND....KLL...EEYLNSNR..............-ENGHNSSDILSREQELSKELHELSRLRSIPGLVLEIETNLELQEFENCYQSLKTLRKKLY......ENEFILNK.SFGLQQSVSRFVDGLHVKFVHQVHEVCKA-FWKV........Q.DDSIALHKRI...KWGKDDVEIEYSAFIESVATLFF..............PEGLV..DSKHWIIDDM.LLAD.LQENVRATLKSIFNDHIHLDVIVEK.MKSLIFVGKKEIAFSDDKDF...lILKGVY........IGNEETTAGTLSNFESILLFLDHTSPPG.AKSVLVRRLCPVLANDLLKVIKKNASGVFGPQESSV.KKKALRVNCLLEKLLNS..........QEDMSKA...IASEIERLLTSEELYVHLQLEKIFQEQLQELR.....................
A0A1G4MGQ1_LACFM/21-362             .....................l-EDLDSLAAAIESD....PNF...RPYEKAST..............--QNTNIDELIKKDAELSGQLSVLTSLKVVSAFIDEFKTNYDLWELENCYYSLQNMHKKLE......-TIDLSNL.SLRFQESLSTYIDSLHADLVDRIKDLLGK-FWSI........D.RHKIQYINNV...RMGEDEIEFEFEGFKVFLETCFY..............SDGHF..DPNSWFTSEI.RMGD.TRDEVSNALSEIYTEYITYSKIITI.LKESLFSSDVQLVLCE----....-DVLLF........QHAKCQTEQVIASFENLAYFLLHISPKS.CSSLILSQLGNTFVNEIVKFVKLRSNEVLTPDSSS-.KLELIKLNQMLVDLSEK..........VNTSWKY...HETRLTSLLYDEHILNNLLLDKLLRNQVVELR.....................
J8Q396_SACAR/5-358                  ....................sh--NKDEIIRELRKD....PLV...IKSDNQKIn............sGELKLDSSELLRQEATLANELNTLDNLKALSTLIVEVKTNLDLLELENCFYSLQSLRTKMR......KNTAFLKQ.SFNFQQSVSSYVDTLHLELVNALHKILTTGFWKI........T.ENSIQFTPTV...KWGKNEVDIEYDTFMDFVVRQYF..............PQSSL..DNQAWIISDM.GNAD.SQEQVRAKLNTILKDYINLTSVVNM.IKCSIFIPGRQVSYEEEKN-....MLVFSQ........SSLQNNTSAALTSFETVCDFVLDRLSLR.DKKTLSYELGHLFNTEFTKFVKNNASIILDSLDSPL.KKLVSVTNDKLIRLASE.........tGVTNWSY...SGKEIQDLLMNKQLYYNLLLDKILESHIKDLR.....................
A0A1E3P269_WICAA/24-196             dpanlraqvenvggvskalsfd--------------....---...--------..............-----ELSKLQQRDYEITQELQQLRELWVISTLLKETEVNLELFEFENVFDSLRNFQKKIK......-SDSLTSS.LIIVDKLQNEH-DRCYDLAIEKIKQCWNE-LIHV........D.NDSIEFNAEV...EINGNLVQFE--NISDVIKTNNL..............QTK--..----------.----.-------------------------.--------------------....------........----------------------------.------------------------------------.-----------------..........-------...--------------------------------ipnsntshlidqkllnsltes
A0A1E4RZ31_CYBJN/19-176             ..........ldklvgeitdvk--------------....--K...LQEQLTLK..............-VDTQQLGELESKDIELQDELDQLQELWYLMTLQKEIEVNVDLFEFETVFHSLSKLKSKVD......-QMNIKSD.A--IRSKLMMEGSRLEDLAVNKLLDCWDQ-IVHV........T.GGSVTLNSEI...HVDGFPISFE-------------..............-----..----------.----.-------------------------.--------------------....------........----------------------------.------------------------------------.-----------------..........-------...--------------------------------avvlivehyslpqprfnl...
A0A1E5RGU1_9ASCO/23-407             ......................LKDQEHIQLEIEND....PKFnelFLAKGQENdnsnai..iahetkNPTIDKKSDILSKDQEYITQIEVLRSLQLIARLIEEFEKCLAKWSFEDAYVKLQQMCEKHK.....tLWQSFPLQlSLQLQKSLTSKLDELHLDFLEKLVKVY-KFFFQT........N.EDKNELVLNV...VSEDGNVSLK--DVHTFVVSSLLehkni....envtkENSTL..FIDTWFIDSIvDSNS.VMEHCLSLMNGVAIKYIKLNNIIDRyIKYVLFHNSVCLSITKNSGLcwsvETSTLS........SNEKVPFERQVENMQNVAALYDFLMVQN.QEYYNFSKLSQTLVKQFENFIKLNVKPLWNKETN-F.KKEIIKIVEKSETLSRSnll...nillDRSGNTY...NSIIMDKLIRE---------------------gfvelrnlfsdttvlekt...
A0A1G4JZV3_9SACH/23-369             ....................vc--DQERILESIEKD....SNL...ALRDNESKv............lHQQVTDVPRLLAHDAGLSKQLGTYQGLSVISDLLDEFSVNFQLWELENCFHSLHNVHRRLQ......NLDS-GTL.PLQFQESLKLHVNTLHLDLLTRCEEVMQQ-MWTI........E.SDSITFNISI...KAGPDQTVIEYLPIREFLDTCLF..............PDGRF..ETTFWFVSSL.GVTD.IKDTVITKLSKLYGLYIGLQEIQGQ.LKSFLFATGAYLETQD----....NCSLRK........IPRHCNAGETIRSFEAIVSFLSEIIWRG.DANTILARLGSTLVVEIIKFSKQNSRQVLGSDTGY-.KEQILNLNNQLKVMSVN..........SNGVWPY...DGRELDSILHDDSVIINLMLDKLLQRQLVKIR.....................
G8ZQK5_TORDC/17-366                 ......................LADRNGILHQLEDD....PVL...INDELREP..............--SKIDTDAILKREMGLSRELREYTALKTVPSLVLEFKTNLHLLEFENSFYSLQTLRKKLR......DFSEILSQ.SYGLQRSVATYVDNMHLDLVNSLYSILNDGFWKI........G.SDFVSFQEKV...AFGNDRVDIDYVDFMASMVSLYF..............PQGHL..DPKSWIISDM.ILGT.MQETVRAKLDFILKEYVKLSGVTNL.IKSCIFAQSSEALLEDNNKT...lKFRQSS........KKGDEKFKETLSSFKNVLQFLTETVVSQ.DKKILAERLGPSISTELMKSIKANASIIFRPENTHL.RDESLAINLILKDLSEN..........-SDIWSY...NGSELERLFSNSDIPTNLQVDKILQDQLTELR.....................
A0A1G4JWI2_9SACH/21-364             ..................lgri----EIVKKSIKND....PNF...ALPRLVVD..............-DRNADINALLKADVELTEKLHAYKELRIIGGLLKEFYVNLELWELESCFYSLRNIHQKLQ......-KNILAGQ.SRQFKQSVNDSVDHLHFQLIERVRDALDG-FWKF........G.KDSITFRSSF...TTESGDNEILYNEISECVKSHLF..............EDAVLgsNSSCWFVSSI.ESIA.TKNVVIQELSAISDKYLKHEQTILF.FKKFLFSSDIVLFLE-----....GSCIIS........ERRTRTIDLTLDSFQNLATFLSGIVSAK.DADLILQSIGNLLVNEIIKFVRQEAAQLLIVSQQ--.RQRLIDINAAMADLSLN..........TAVHWCY...DRSKLDVLLADEKIIIDLKLDQILHDELLKLR.....................
Q6FNZ0_CANGA/3-351                  .....................y-ADKDHVITELLKD....PVY...LSRHNSLA..............-THPKDENDLYALETKLEEELHDLKDLKIVSSLVKETQVNLDLMELENCYYSLYNLSKKLK......SSRSFLKQ.SLHFQRSVAVHVDELRIKLLSTIYDILATKFWSI........S.ESSFEFHPDI...KWKEEEFMMKYEEFKSFVSKSFF..............PDNAI..NNSHWLITDI.IHSE.EQERMRNKLKDIYINYIDFASLTKA.VKDALFSDEYEFEWSDNNY-....TKLLIT........KRGALCIQKRIESFNNLLSFLEKGISNS.DKFKLLTNLGKAIGIEFLRFVKSNATGIIDKNANSI.KQQTLLLNDRLKTISEQ..........-SGAWNF...DSDQISKLLNDEILYKSLLLDGVLGRAISDVR.....................
C5DYW5_ZYGRC/12-364                 ....................ll--SKAEILESLGKD....PLL...VNEKESKSd...........nkDDTPVDFEGILKRESSLNQELHDLASLRSISGLIMEFKANFELLELENCYYSLQNLRKKLR......DTSSLTKQ.SFSFQQSVFSHVDTMHLQLVGKLYEIISQWFWQV........N.GDSITFKRLV...ELGEDSETMEYVPFITFVEQQYY..............PDGFL..DPDLWVIRHM.KVGS.SQDTVVENLNSILRDYLNSNLMIET.IKRFLFAKGGKITWEDLGNT....QKLHFK........QSGTDKVGERISNILNVVSFLNEGITPH.DKHALAEKLGPLLANDLLQSVRSNAYSVLHSSDSPL.REEVSLVNEKLKFLSND..........--TRWNY...QSNDVEDLLNDDQVHKNLLLDGVFENYALKIR.....................
Q752C3_ASHGO/45-390                 ......................LGNPMQVLAAIEDD....PSL...WLDSSEKK..............-PNHLALQELKQRDVEVTKTLQQHLRLKIVADLLIKYNSEIQCAEFTAAFETLRQCVQKAK......-SADVSAH.GVRFEQAFNTYLSGLHAVFVRKLQGLLEE-VWHI........H.DDGFSFQQQVsekLDDAREHNFDYDTLVDMFNSCFL..............KDGDI..DERSWFFKNI.SMPD.VRDDVKQCVNSTYNNYIKLSQVKEN.LKGFLFSDSLRISCS-----....GTRLHV........DQGCETPAAKVESYVVLADYLLNVLSPV.ASNQILMTLGGAIVTEATKLLKQHSKELLSKEANQ-.KKDLAHFNDTLVKLSSR..........KGSSWTY...NGNALDKLLNDPETFATLMFEQHVHLHLLKLR.....................
A7TF57_VANPO/11-362                 .....................v-ADKERLLQLLRND....PLL...SLNDDVEI..............-TEKIDLEGLLKLDASLTEELHVLNSLKTIPSLILEFKANMEYLELENCYYSLQNLRKKLK......ENDTLVRQ.NIRLQQSVATYVDSLHVQLVDKLFDLISNHFWNF........K.EHTISHKDEI...VYGKDKVKFDYETLLEFVNRDIF..............PQNVL..DFEHWLIKDM.VMGD.LQEIVRERLSTIVKSYILFDSIIHD.VKENIFNDKGIFTYDEDSKK...lSLVDSR........SKDLDLLTEKLVGFGKLADYLLSCISKR.DVVILSSRIGPSIAKESHKLIKENISSILQEQSTSI.KNLILELNDKLLSLSNA..........TNGVWNY...SGNETEELLNDKQIYNNLLLDKIFEEQVNRIR.....................
I2GW53_TETBL/22-390                 ......................LNNRDILVASIKND....IES...TIEDSPTQppt.......iethIKAHIDPFVIQQEDTQLSNDLYELNKLKTITSLIMEFKTNYELMEYENCYYSLQNLRKKIH......ENEPILVK.NYHLKQSLSSYADGLHVQLIEAIHSLVSKGFWKIptvsasdnQ.NVSIEFQKII...HWGNGHIEFEYEFFIDFLRDALF..............PDSKF..DLQNWLITEL.VSTD.LQQIVKDNMDSLFNEYIQFSTLVHV.LKTGIMNRNYSIVLTGEASN...iINLQTK........LNSKSSIQDYLYSLENIIEYLKNTLLER.DSITIFNQIGNYFFNEIIKLIKSNTYIILEDDGNDIlKSQISKICNTLSFLSKR..........NTSIWKF...DEDEITHLLNNRQLQSNLLVDKLFETKITTIR.....................
A0A376B2R6_9ASCO/21-405             ......................LSDQNSLQLAIKND....KNY...NQVFGPTVdn.........tpsITSPEDLDRLKNQDSEYIAEIDQLLLLKTINQSLNEFQTNLKLSEFENCYYTLKNLVNQFNkllnlaETNS-YQI.KPTLPKSISNKIDSLHLDFLTLLENMYNR-LIAIrd...vdaN.TKVLNINRSI...----GNNELHLKELNEFMVKTLLesqesiatknpiayNGPDS..TLKIWFITSI.TETS.KVEECLKRLDHLITTYLQLSPILNKfVKCFLFSSKIQVELTTTGDEr..lDLKLIE........SAENLSLQDYLTSFINMVQFVDSLIGWDsKLMAFFEPVSTLFQKELEKFIKLNIKEILKVGNDA-.-EHHNALLLNLQKLLSQee......gkKSSILTLcgnSKTNLSLLLKDEKVYKQVILDQLIQQKFEELR.....................
A0A1V2L1Q6_CYBFA/15-195             ...deqitrlvavdslktqlsa--------------....---...----TSHR..............SLDIKELGQLQARDGQIVTEIEQLQELWVITTLKKEVEVNLEMFEFENVFASLQKLTEKIQg....iSLNSASVK.TKWLERATQLQ-DEVLETFTKTWKQLVSVDEESS........G.AVSVTFHEEV...--EIDDFAIAFESLADVVETFAL..............PQNIF..NLAH------.----.-------------------------.--------------------....------........----------------------------.------------------------------------.-----------------..........-------...--------------------------------tidtcfmdtyldd........
A0A7H9HNE0_9SACH/16-365             ......................LGNRDEIARRLDND....PLL...RKNEDGES..............--LKIDLEAILRREKELSNELHDFTALKTIPGLILEFKTNLQLLELENCFYSLQALRRKLH......ANFSIINR.SFGLQRSIMTYVDNMHLELVNTLFATLKDGFWKI........N.ADAIEFQSTV...THGDDQVQLQYADLMDSVENLYF..............PSGQL..DQKLWIISDM.VLGT.LQETLRDRLNTILNEYVKLSDIVSL.IKSCLFAENKQFMLANDNSK...lIFEDST........KDGDEKVEETANSFKNLLLFMRETVWLR.DQKILAQKLGSLIATQLLEFIKVNSSVVFRPENAQL.RVIIGEVNQDLVKLSTE..........-TSSWSY...DGTAINDLFNNDQIPMNLHIDKVFHEQITELR.....................
G0WD68_NAUDC/10-396                 ......................LSNKDELISSIKDD....LLL...LQNKNNITttgndaeddlnvskMDKTPDVNTILTKETQLATELHDLQQLKTISSLIMEFKTNFELFELENCFYSLQSLRKQIGtitinnNNPSFARQ.NYHFQRSVIVYIDSLHLDLISRIFEIITLKFWNI........T.SESISFNPKLnvqTTDGLDVEIAYDSFISSIKNLYF..............PNDII..DSEFWIISNV.ELND.LHESIRNKLQTIFKDYINLDGVSAM.IKNAIFTNNKQFKYANNKLS...iISSLTS........MNQTDFLTTTIESFQNIITFLNETLPLQ.DRNILLSKLGNTITTELLKFVKVNISKILNNENSNLmKDQTLKINTELITFAKHftlsssshsgLNNFKNY...DGQQIIELLNNNRIYYNLLLDNSLYDQIKQMR.....................
H2AUI4_KAZAF/5-354                  ......................LPDRETLISLVEQN....-LI...LKNKNTID..............-DPSLEMNKILEEESKLSEELRDLTKLKTISSLLKEVNVNFELLEFENCYYSLKSLRSKLT.....eNNSVFIKQ.TYRFQRSTALYIDSLHSKLIDSIHEVITTKFWNI........T.SNTIKFNPKI...KIGDDDVQFDYTEFMSFAKSSFF..............TKDTS..SSEFWFLATM.ELGD.YKENVRSKLNDINRNFIEFNNIIGS.IKNLIYDDSVNVTYSTQDN-....ILSFQK........GESNDYLEKIIEKSQAIVNFLTETFLPN.NLYVIVSEVGSLLSTELFKTAKSNASQLLRDRKNPL.IDLVRSINSSLIKLSNE..........IKSNWKY...NGSDIDHLLNDEKVYINLLIDKTFDAEIKMLR.....................
C5DK93_LACTC/23-365                 ......................LNDQDAILAGIESD....PNL...KMEGSARR..............-EEPSDVQAILNQDVQLSKKLGALKELNLVANLIDEFKANFELWELENCYYSLQNLHKRLE......-KVDMSLF.PIQFQGLLKVHIDSLHVDLLSRIDKVMRQ-FWDI........S.ARSVTFNQKI...AVDRDDVLLEYDSFSLFLKSCFF..............SQDHF..EPTSWFVATM.NMGD.AKDKVTNLLATAFNEWVRLQTVQEK.LKQFLFSANVCLSLK-----....GCTLGA........SENPGNLDDTLKSFEALVMFMKDVTTAE.DTAVILAKLGNTLLTEIVKFVKQNSSHLFAPGTNY-.KNSVVSLNTMLTELSHK..........GGKSWQY...AGRELDNLINDDSVINNLMLDKLLQEQISAIR.....................
A0A1S7HMD7_9SACH/12-362             ....................ll--NKDSVLASLKDD....PLL...TGAKDELTn............nDPATLDYDAILRKDSRLSQQLHDLSSLRSVSGLIMEFKANFELLEFENCYYSLQSLRKKLR......DNAAINKQ.GVSFQQSVLAHTDAMHSQLVHKFYEIITQHFWQV........T.DESIAFEPIV...RLGVDSENLDYVSFMRFIEQQFY..............PDGFL..DANMWIIGDM.RVGP.TQDAVISELNAIFHDFLNFRMIIEV.IKKFLFSKAKQIVFERGNC-....VKLSLH........RGGEDNVSDRIANINNVACFLCEGISVR.DIDTFAKKLGPVLATELIQTIKSNPYTVLPSSHSQI.RADVAMANQNLRQLAKK..........--SNWTY...HGSDVENLLNDNQVQNSLLLDGIFERYALKIR.....................
A0A0C7N2K0_9SACH/24-368             ......................LSDQDSISANIECD....PKL...QFLDVPSA..............NETSTDIQALRAQETLLSDQLVVCRELSVVSDLLEEAKMNLQLCELENCFYSLQNIRRKLT......-VIDFKIL.PMRFEQDLKLHLDEMHAHLVSRCDDIMHG-FWKI........D.DCGITFVEST...IVGTDRVEFNYSYFRQFLKTCFF..............PNGSF..EPTIWFVSSL.SMSD.TKEAITTGLSTLFTQYIELEVVQEK.LKSLLFSENVFLELKS----....ESTLEV........TTKKCSLDEILCKYTALVLFLLRAVTSD.DQNTILSRLGNTIAVEVLKFFKQNSTVLLSPGSKQ-.KEQLIRLNDDLKLLSDS..........TKGVWVY...NGTELDALLNDDSVINNLKLDKLLQSQIVKIR.....................
#=GC SS_cons                        ......................XXXXXXXXXXXXXX....XXX...XXXXXXXX..............XXXXXXHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXHHHHHHHHHHHHHHHH......HXCCHHCS.XHHHHHHHHHHHHHHHHHHHHHHHHHHHCTTEEE........X.SSEEEEXSEE...EETTTTEEEEHHHHHHHHHHHHX..............CCCSX..XTTSHHHHTX.SSHH.HHHHHHHHHHHHHHHHTSXHHHHHH.HHCCTTXTTEEEEEETTTTE...EEEEEXX........XXXXXXHHHHHHHHHHHHHHHHHTSXHH.HHHHHHHHHHHHHHHHHHHHHHHTHHHHTSSTTXCH.HHHHHHHHHHHHHHHHH.........HT-SSXXX...XSHHHHHHCHXHHHHHHHHHHHHHHHHHHHHH.....................
#=GC seq_cons                       ........................sp-plltplcpD....Phh...htpcssps...............ppph-hspllp+-spLop-LcsLppL+slusLlhEFcsNh-LhEhENCaYSLQsL+KKlc......pssshhpp.shpFQpSlssalDsLHlpLlp+lh-llsp.FWpI........s.scSIsFpppl...phst-slph-Ypshh-hlcspaa..............ssshl..-.phWhIssh.phss.hp-pVpspLssIhppYlphs.llph.lKphlFspshphthpptt.......hhh.p........ppsppphpptlpuapslspFlppsls.p.ct.hlhpcLGshlssElhKhlKpNsp.llpspss...+pplhtlNppLtpLupp...........ts.WsY...susclppLLpscplh.sLhlDplhpppl.clR.....................
//
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