#=GF ID   DurN
#=GF AC   PF19375.5
#=GF DE   DurN substrate-assisted peptide maturase
#=GF PI   DUF5950;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   23.90 23.90;
#=GF TC   34.80 75.40;
#=GF NC   23.80 20.00;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   30177849
#=GF RT   Substrate-assisted enzymatic formation of lysinoalanine in
#=GF RT   duramycin.
#=GF RA   An L, Cogan DP, Navo CD, Jimenez-Oses G, Nair SK, van der Donk
#=GF RA   WA;
#=GF RL   Nat Chem Biol. 2018;14:928-933.
#=GF DR   INTERPRO; IPR045994;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC) involved in duramycin biosynthesis, a ribosomally
#=GF CC   synthesized and post-translationally modified peptide (RiPP)
#=GF CC   produced by various actinomycetes and marine symbionts.
#=GF CC   Duramycin binds phosphatidylethanolamine (PE), a major
#=GF CC   structural phospholipid in mammalian and microbial cell
#=GF CC   membranes which contains 19 amino acids and 5 post-translational
#=GF CC    modifications (PTMs). This entry represents DurN, an enzyme
#=GF CC   that forms (2S,9S)-Lal one of the two last PTMs. DurN catalyses
#=GF CC   stereospecific and diastereoselective Lal formation in an
#=GF CC   unusual substrate-assisted mechanism in  which the active site
#=GF CC   residues that make the reaction proceed come from the substrate
#=GF CC   itself, manoeuvred into position by DurN [1].
#=GF SQ   15
#=GS A0A853BJU6_9ACTN/15-117  AC A0A853BJU6.1
#=GS A0A7W8QHT7_9ACTN/15-116  AC A0A7W8QHT7.1
#=GS A0A840NF74_9PSEU/16-118  AC A0A840NF74.1
#=GS A0A9W6RZE3_9ACTN/17-119  AC A0A9W6RZE3.1
#=GS A0A326UM79_THEHA/17-119  AC A0A326UM79.1
#=GS A0A2P4UCX4_9ACTN/20-122  AC A0A2P4UCX4.1
#=GS A0A543CCG8_9ACTN/15-117  AC A0A543CCG8.1
#=GS A0A3M2LW14_9ACTN/21-122  AC A0A3M2LW14.1
#=GS A0A372JNN6_9ACTN/1-103   AC A0A372JNN6.1
#=GS A0A4R5BUC2_9ACTN/16-118  AC A0A4R5BUC2.1
#=GS A0A1T4SL45_9ACTN/15-117  AC A0A1T4SL45.1
#=GS A0A7X0L1H1_9ACTN/20-122  AC A0A7X0L1H1.1
#=GS A0A9W6UVB5_9ACTN/24-126  AC A0A9W6UVB5.1
#=GS A0A931GK11_9ACTN/20-122  AC A0A931GK11.1
#=GS A0A6I5VMB4_9ACTN/11-106  AC A0A6I5VMB4.1
A0A853BJU6_9ACTN/15-117             IRRIQQLVVLCSLLPPDGKLRELLETALAVHEEPLLAHVGPVPDLH.PHAVKGWLESFWLRDDITPEERQVVDWQSDSDNMGAAMRELSNVEQQTGMRLIAEK-s....
A0A7W8QHT7_9ACTN/15-116             IRRVQQLMVVCSLLPDDGKLREALQAALALPDRPVLDRTPPVPDLH.PHRLKGWLESIWLSDSPSPEEKALVDWQSDSDNMTAAMRELDEVERHIGARLSI---vl...
A0A840NF74_9PSEU/16-118             IRQIQELVLFCSLLPPDGKLREVLELALALHEEPMLSRLRPVTDLH.PFSTKEWMESLWMHADLPANEKEVVAWQNKDENMSPALVELKNVEQQLGISLVAR--lr...
A0A9W6RZE3_9ACTN/17-119             IRQVQQLMIFCSLLPPDGKLREVLTRALDLHEEPILSRITPMTDIQ.PHATKAWLESIWIESGLSPDEKELVRWQNDSDNMAAAIRELQNVERQIGIRLVAEK-t....
A0A326UM79_THEHA/17-119             IRQIQMLLVLLSHLPPDSMLREIFEHAMALPHDPWAARVTPVTDTS.FYGLKTWLESLWARDGLSADEQRLVDWQRSGKNIEIAVRELKAIQQLTGFKFGIVA-l....
A0A2P4UCX4_9ACTN/20-122             VRQLQHLMVLCELLPPGSRLHEALTIALSINEPSLPGRITPVRDLH.PLTTKTWLESLWDPDLISPEEMELVAWQNNKAKMDAAVEEMQKIERRIGIRLATEKI.....
A0A543CCG8_9ACTN/15-117             IRRVQQLMIFCSLIPPDGKLREVLSLALSLHEEPVLSRVTPMSDTQ.PHAAKAWLEAIWLENGLSAEEKELVRWQNDSENMAAAIAELRNAEGQLGMRLVAET-t....
A0A3M2LW14_9ACTN/21-122             VRQIQHLLVLCSLLKQDGPLARAMATALRLDPLPMAARAEPVPTLH.PQATKDWLESFWDPAALTPDEVEVAAWQNNITEMVTAVEEVHAIEKLIRIRLTTE--l....
A0A372JNN6_9ACTN/1-103              MRQIQHLLVLCSLLRRDSPLARILTTALELDPVPMAARATPAPSVH.PQETKDWLESFWDPAALTPDEVEVAAWQNNITEMVTAVEEIHAIEKLIDIRLTSEK-a....
A0A4R5BUC2_9ACTN/16-118             IRRIQHLMALCSLLPPDGKLREVLELALSLNEETLLPHVEPLADLH.PHAVKTWLECLWIHDGLGPEGKELLAWQNTSDNMAAAMRELRNVETQTGITLAAEA-t....
A0A1T4SL45_9ACTN/15-117             IRQIQSLMILCSLLPPDGKLREALQIALALHEEPLLAQITPISDLH.PHTAKEWLETLWRRDDLSPQVKELVDWQSNSDNMSAAIQELRNVEQQSGMKLVAVK-p....
A0A7X0L1H1_9ACTN/20-122             VRQIQFLMVLCSVLPPDGKAREMLRLALDVRNEEFPDGVEPIRDLH.PQATKTWLEFFWTRVGISPEERELIDWQNDKPSMDIAVEELQEAERRLGIRLAPRT-v....
A0A9W6UVB5_9ACTN/24-126             VRQIQHLMLLCSLLPPDGAMQKILRRALSLHEEPLLARVTPVTDLH.PQATKEWLESFWIRDGISPEEEELIAWQNDKPTMDAAIAEIANVERQLGIRLVT---alv..
A0A931GK11_9ACTN/20-122             IRQIQHLMLLCSLLPPGGKLHEILRLALSVHDENLPAHVSPVRDLH.PQATKDWLESIWDRADISDEERELVVWQSDKPNMDAAAEELQRIERLLGIRLATE--iv...
A0A6I5VMB4_9ACTN/11-106             IRYLQGLAVLLSCFPKGGKVHEFFQLALDAEGPAVLARANVDAALDdDAELKAWLEKLWAPEGLHASEQGLVEWQNNSDNMTAALDELRAV-------------vgnfg
#=GC seq_cons                       IRQIQpLMlLCSLLPPDGKLRElLphALuLc-EPlLuRlsPlsDLH.PpusKsWLESlWhcsuLSP-E+ELVsWQNsscNMsAAlcELcslEpplGIRLssct.s....
//