GenomeNet

Database: Pfam
Entry: EAD5
LinkDB: EAD5
Original site: EAD5 
#=GF ID   EAD5
#=GF AC   PF19957.2
#=GF DE   Effector-associated domain 5
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF SE   Aravind L
#=GF GA   27.00 27.00;
#=GF TC   32.10 51.30;
#=GF NC   24.70 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   32101166
#=GF RT   Highly regulated, diversifying NTP-dependent biological conflict
#=GF RT   systems with implications for the emergence of multicellularity.
#=GF RA   Kaur G, Burroughs AM, Iyer LM, Aravind L;
#=GF RL   Elife. 2020; [Epub ahead of print]
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Effector-associated domains (EADs) are predicted to function as
#=GF CC   adaptor domains mediating protein-protein interactions. The EADs
#=GF CC   show a characteristic architectural pattern. One copy is always
#=GF CC   fused, typically to the N- or C-terminus, of a core component of
#=GF CC   a biological conflict system; examples include VMAP, iSTAND, or
#=GF CC   GAP1. Further copies of the same EAD are fused to either
#=GF CC   effector or signal-transducing domains, or additional EADs. EAD
#=GF CC   pairs are frequently observed together on the genome in
#=GF CC   conserved gene neighborhoods, but can also be severed from such
#=GF CC   neighborhoods and located in distant regions, indicating EAD-EAD
#=GF CC   protein domain coupling attenuates collinear transcription
#=GF CC   requirements.
#=GF SQ   35
#=GS F2RGA1_STRVP/1440-1572      AC F2RGA1.1
#=GS A0A646KTF2_STRJU/4-136      AC A0A646KTF2.1
#=GS A0A6I6S879_9ACTN/4-136      AC A0A6I6S879.1
#=GS C7PUM2_CHIPD/3-135          AC C7PUM2.1
#=GS G0FN91_AMYMS/5-150          AC G0FN91.1
#=GS D2R1J4_PIRSD/304-401        AC D2R1J4.1
#=GS A0A3D9LU76_9ACTN/1425-1557  AC A0A3D9LU76.1
#=GS A0A0G3AAP3_9DELT/889-985    AC A0A0G3AAP3.1
#=GS A0A0D7CFN5_9ACTN/4-136      AC A0A0D7CFN5.1
#=GS A0A1B6ARU8_9ACTN/4-137      AC A0A1B6ARU8.1
#=GS A0A1H0W5Z0_9PSEU/5-148      AC A0A1H0W5Z0.1
#=GS A0A652L9Y5_9ACTN/1405-1537  AC A0A652L9Y5.1
#=GS A0A1H7RXK1_9BACT/3-134      AC A0A1H7RXK1.1
#=GS A0A2P2GKA6_9ACTN/1422-1554  AC A0A2P2GKA6.1
#=GS A0A1G6RZ25_9PSEU/5-150      AC A0A1G6RZ25.1
#=GS A0A344U9L9_9ACTN/5-136      AC A0A344U9L9.1
#=GS A0A542QK06_9ACTN/4-139      AC A0A542QK06.1
#=GS A0A1L6L3T3_9DELT/50-168     AC A0A1L6L3T3.1
#=GS A0A1D8G8D9_9ACTN/14-146     AC A0A1D8G8D9.1
#=GS A0A1L6L257_9DELT/1-95       AC A0A1L6L257.1
#=GS A0A0X3W374_9ACTN/4-136      AC A0A0X3W374.1
#=GS S9P7V4_9DELT/12-144         AC S9P7V4.1
#=GS A0A1S2JX66_9ACTN/4-136      AC A0A1S2JX66.1
#=GS A0A1L6LFS4_9DELT/3-162      AC A0A1L6LFS4.1
#=GS A0A2T7BGC7_9BACT/3-144      AC A0A2T7BGC7.1
#=GS A0A371PR31_9ACTN/4-138      AC A0A371PR31.1
#=GS A0A1D7VKX5_9ACTN/6-140      AC A0A1D7VKX5.1
#=GS A0A495TXI4_9SPHI/4-142      AC A0A495TXI4.1
#=GS A0A0H5CZF2_9PSEU/5-145      AC A0A0H5CZF2.1
#=GS A0A2R4SWT3_9ACTN/4-136      AC A0A2R4SWT3.1
#=GS A0A0G3UTY9_9ACTN/5-137      AC A0A0G3UTY9.1
#=GS A0A117IVV3_9ACTN/4-136      AC A0A117IVV3.1
#=GS D2R1J3_PIRSD/3-148          AC D2R1J3.1
#=GS A0A429RYI5_9ACTN/5-137      AC A0A429RYI5.1
#=GS A0A0A8F1W7_9ACTN/4-136      AC A0A0A8F1W7.1
F2RGA1_STRVP/1440-1572                 .FLRQQELVRVRNAAMAA..GLADR.SLRPSLLKGVPGYFTATLEPLD.DPREQVHADLNAMNQVERLIDGLVPMEIWLHNAIEHTHEPGP.RAVL............QGA.LDSVAR.AITG...........EAELPADMM.PG-.-EMKEEIVLQDDTVPYEFLH.........................................................
A0A646KTF2_STRJU/4-136                 .YLSPEEILRVRDAALET..GLADP.MVRPLLFDGILPRYRGTLPLLA.APGMQVHSDLNQMNRVERLVDGSVPLEIWLRNAIAQTTEAAA.LTLF............QRI.LDDVAR.SAGG...........EPDIVAQTP.AP-.-EIKEEIVHRDDTVPFAFLR.........................................................
A0A6I6S879_9ACTN/4-136                 .YLPADAVLRLRDTALET..GLGDP.ALRPLLFDGIMTRYRGTLPVLA.APGHQLHSDLNQMNRVERLVDGSVPLEIWLRNAVAQTTEAAA.LATF............QGA.LDEVAR.QAGG...........EPDVLAGRA.AP-.-EIKEAIVHRDDTVPIGFLR.........................................................
C7PUM2_CHIPD/3-135                     .YLSPVEVNDLSLAIA--..AATDPiANRGALYQSVDPRVMMVMPIGGgAILPKLMTEISFMNNLERITTGQVPLQIFLQNAALLVSVLPA.SEKT............VRLlLEKVIQ.LSSG...........APPVNIAMA.P--.-IINQTFIHRDDMVTFSFVE.........................................................
G0FN91_AMYMS/5-150                     .YLNDAALEEVRRAAIDL..GFADE.QNRLALAAGISRAFVDAFTTGG.TGVAKLLTLTSRMNGTRVLLSGEVPLQTWLNNAILLSAGTEE.ELVF............RRA.LEIVSV.DGIAppttspsdapaAAPTDAAEL.PRT.DGELEITIVEDDTLDVGFLH.........................................................
D2R1J4_PIRSD/304-401                   .YLTHDQVLDLCRLLVGA..FPTD-.ESIASLFLGIAPEIVASLPSGN.NPKEKLLNRLQALNNIGRIIGGQSPLQLILKTAALLRESFPD.EQIL............QQY.LAIVS-.----...........---------.---.--------------------k........................................................
A0A3D9LU76_9ACTN/1425-1557             .FLPQPELVRVRNAAMEA..GLADR.SLRQALLKGIPGYFTAELEPLD.DPLEQTHADLDAMNQVERLLDGLVPLEIWLHNALEQTHEPGP.RAVL............QGA.LDTVAR.AITG...........EAELPAEMM.PG-.-EMKEEIVLQDDTVPYEFLH.........................................................
A0A0G3AAP3_9DELT/889-985               c-LTHERLLKVHDAAVSA..GLARA.--REELLAGVEPRVVSGLPLQS.NTAGQLLSDLTRLNQISRLDTGLIPLRTWLENALEMTDKRRE.QAEF............KRA.LRA---.----...........---------.---.--------------------idd......................................................
A0A0D7CFN5_9ACTN/4-136                 .YLPPDAIQQVSDAALES..GLAEP.ALRPLLFDGIMLKYRGGLPLLP.APGPQVHSDLASMNRVERLVDGSVPLGIWLRNAVAQTTESAP.LAVF............QRA.LDEVAR.QAGG...........EPDILAEHP.AP-.-EIKEEIVHRDDTVPIGFLR.........................................................
A0A1B6ARU8_9ACTN/4-137                 .YLSPDEVRRVLDAAVET..GLADP.AVRPLLFDGIMPRYRGTLPLHP.APGRQVHSDLNEMNRVERLVDGSVPLEIWLRNAVAETTEAGP.LTVL............QRA.LDEVAR.AAGG...........EPDVPGGLP.LP-.GEIKEEIIHRDDTVPIGFLR.........................................................
A0A1H0W5Z0_9PSEU/5-148                 .YLTSDELREVQQAAVAL..GFADP.DQSAALTATISRAFVATATQGG.TPMAKLMSLTARMNTTRALVSGEVPLREWLGAAIPMAGGQPE.EMVF............RRA.LELMSA.DGRArttp..gddptPVLADMDDL.PRS.DGELEVVIFEDDTLDVAFLH.........................................................
A0A652L9Y5_9ACTN/1405-1537             .YLSPEDVVRVRNAALDA..GLAES.AVRPLLFDGTTPRFRASLPVLD.SPLRQTHSDLVAMNRVERLIDGTVPLEVWLRNAIAQTLEAGP.LTVL............QRA.LDDVAR.DAAG...........EPDVPPGAL.PG-.-ENKEEIVFRDDTVPFEFLH.........................................................
A0A1H7RXK1_9BACT/3-134                 l-LTQQEILKLADALI--..GSLDPaGSRIALLQSIDRRFVAVFPQAG.APAAQMMVDIGYMNDVERLTSGVVPLQQYLQNAAFLLYGAGQ.NEVT............VRAiLDLVTQ.RATG...........APRPDVENI.K--.-EIKEQIIHADDMVTFAFME.........................................................
A0A2P2GKA6_9ACTN/1422-1554             .YLTDEELLRVQSAAVEA..GLADT.ELRPKLFAGTTRHFRAGLPLQR.TPFEQIRSDLRTVNRVERLIDGTVPLEVWLRNALTMTVQPGP.VAVF............QRA.LDDVSR.DAAG...........EPELPVDFL.PA-.-EFKEEIVFRDDTVPFEFLQ.........................................................
A0A1G6RZ25_9PSEU/5-150                 .HLTPSALKEVQHAAIEL..GFADD.GMLAALTSGIPPAFVASAMQGG.QGVAKLMTLTSRMNCTRVLLSGQVPLLQWLDNAVLLAAGRPE.EMVF............RRA.LEIASV.DGDAppttspvdepaAAVPDVESM.LDD.RGALEVVIAEDDTLDVGFLH.........................................................
A0A344U9L9_9ACTN/5-136                 .YLPREDILRLRDTALET..GLADP.STRPLLLAGIMPRYRGVLPVLA.APGAQVQSDLEAMNRVERLVDGSVPLEIWLRNAVAQTAEAGP.LAVF............QSA.LDRVAR.DAAG...........EPDVP-EPP.SG-.-ETKEEIVFRDDTVPFEFL-l........................................................
A0A542QK06_9ACTN/4-139                 .YLTAHEILQVRDAALET..GLADP.MVRPLLFDGIMPKYRGTLPMLP.APGRQLHSDLNEMNRVERLVDGSVPLEIWLRNAIAQTTEAEP.LALL............QRT.LDDVAR.SAGG...........EPDIMAGMPgSDI.REIKEEIVHRDDTVPFDFLR.........................................................
A0A1L6L3T3_9DELT/50-168                .HLPLEDITAIHKAAVKL..GLGAS.--RSALLGGLDPAFTASLAIHP.SPAAQMLTDLHTLNGIEALTDGSVPLHVWLTNALDLTSTTRE.SEVF............ARA.LEVLGG.AART...........AA-------.---.--------------------alpggaelerfiqqsn.........................................
A0A1D8G8D9_9ACTN/14-146                .YLAREDVLAVRDAALDA..GLADP.AVRPLLFDGVLPRYRATLPLLA.APGLQVQSDLVEMNRVERLVDGSVPLEIWLRNAVAHTTAAAP.MAVL............QRA.LDDVAR.DAGG...........EPDVMAGRA.VP-.-EIKEEIVHRDDTVPFTFLR.........................................................
A0A1L6L257_9DELT/1-95                  m-----------------..-----.-------AGLDQGLVATFPRAA.NAAAQLLGDLNRLNDIGQLSDGSMPLRTWLDNALALCGPVSQ.AQVF............REV.LTLLSAsRASGm.........aPPSPSM---.---.--------------------apapaaaggst..............................................
A0A0X3W374_9ACTN/4-136                 .YLPPEAILRVRDAALDS..GLTDP.SVRPLLFDGVLPRYRGTLPILA.APMRQLHSDLAQMNQVERLVDGSVPLEIWLRNAIAQTTEAEP.LRVF............QEA.LDEVAR.RAGG...........EPDVLPGGA.AP-.-EIKEQIVHRDDTVPIDFLR.........................................................
S9P7V4_9DELT/12-144                    .YLKQDELLELTTVALRM..GLGNP.MTQMTLLSSLNPQFAGSIQTLGlSPSTMLLNTLNRLNHTERLTDGSVPLAAWLKSALAVAGPVED.AKVF............AQA.LSVVSQ.RSSG...........APPIELENV.P--.-ERKERIIHQDDMVSFGFF-t........................................................
A0A1S2JX66_9ACTN/4-136                 .YLSSEAVLAVKDAALDS..GLVDP.SVRPLLLDGILPRFAASLPLHA.APAVQVQSDLVRLNQVSRLVDGSVPLEIWLRNAVAQTAQTAP.LAVF............QQA.LDDVAR.DAGG...........EPDPLAGRP.AA-.-ELKERIVHRDDTVPFGFLR.........................................................
A0A1L6LFS4_9DELT/3-162                 l-LDQDDLRALHRAVVDD..GLAGD.AGLDALLEGLSPGYVTTLPVGG.VPAIRLLRVLSRLSQDGQLRDGTVPLRVLLENAAHLAAGRRG.AALFddmlrrlgpsraS--.------.----...........---------.---.--------------------rdkdgasplrllflsaqpesettlnpgrayraieeaiakaggkdqihlasgwavrpt
A0A2T7BGC7_9BACT/3-144                 .YLNQQERNDLNDAIYNT..IGYEA.SIRRIFLAEVHPGFRALLFTDHnHSMVQLELDVIQLNDTPRLTDGTIPFYAWLQQAARHVRLFPA.AAAT...........vDRA.IAKLEG.QGTKaa.......gsATVLPAPST.STIlQIEKERSISGNEMLSYAWL-a........................................................
A0A371PR31_9ACTN/4-138                 .YLSPDEIRRVLDAAVET..GLADP.AVRPLLLDGIMPRYRSTLPLNP.APGRQVHSDLNEMNRVERLVDGSVPLEIWLRNAVAETTEAEP.LTVF............QQA.LDDVAR.QAGG...........EPDVLAGLP.TPA.SEIKEQIVHRDDTVPIGFLR.........................................................
A0A1D7VKX5_9ACTN/6-140                 .YLSPDEIRQVLDAALET..GLADP.AVRPLLLDGVMPRYRGTLPLNP.APGRQVHSDLNEMNRVERLVDGTVPLEIWLRNAVAETTEAEP.LTVF............QRA.LDEVAR.KAGG...........EPDVLAGLP.SPA.AEIKEEIVHRDDTVPIGFLR.........................................................
A0A495TXI4_9SPHI/4-142                 f-LNDQQKRKVVDQIGGN..IGYRP.EIRQIMWNDINRQFRDMQPANS.PDLLQLILDVNVLNRTPRLTDGIIPFESWLQKAAWLLKPYPDaLAVI............QTA.LNTISL.QQSAqq.......ivNQVPPSPEL.L-Q.KAQLEKTIHRDDMVSFAFLE.........................................................
A0A0H5CZF2_9PSEU/5-145                 .HLTPAELTKVQQAALAC..GFASE.GEMAALTADISPVFVATATQGG.TPAARLITLTSRMNTTRALLSGQNPLRLWLDKAVLLAAGRPE.ELVF............RRA.LEVVEI.DGSAmai.....dapAAPMDVDTL.PGV.DGELEVVIFEDDTLDVGFLH.........................................................
A0A2R4SWT3_9ACTN/4-136                 .YLSPDEILRVRDAALET..GLADP.SVRPLLFDGIMPKYRGTLPLLA.APGRQVHSDLNEMNRVERLVDGSVPLELWLRNAVAQTTEAAA.LAVL............QRA.LDDVAR.KAGG...........EPDVMAGVP.VP-.-EIKEEIVHRDDTVPFGFLR.........................................................
A0A0G3UTY9_9ACTN/5-137                 .YLPSEEVVRLSDAALEA..GLADP.VVRTLLFDGIMPKYRGTLPLLA.APGLQVRSDLNAMNRVERLVDGSVPLEVWLRNAVAQTVAADP.LAVF............QRA.LDEVAR.NAAG...........EPDVPAGPA.EG-.-ETKEEVVHHDDTVPFEFLQ.........................................................
A0A117IVV3_9ACTN/4-136                 .YLSPEELLALRDAAVDA..GLADP.SVRPLLFQGIMPRYRSTLPLLA.APGLQVQSDLAEMNRVERLVDGSVPLETWLRNAVAQSTAAAP.VAVF............QRA.LDDVAR.GANG...........EPDVLAGRP.VP-.-EIKEEIVHRDDTVPFGFLR.........................................................
D2R1J3_PIRSD/3-148                     .YLTQDQIHEIHSQAVNRtpGLLDA.--WKQMLIGLPIAYMSTLPNIDgNKNLGLLAQLSTMNEVDVIKGGVVPLEVWLNNAAYFSELFPD.SQKLyrdya..rvileKRA.ITKRNA.TSSF...........DQTVNAPSL.KGM.SEVKERIIFINEMVPYGFAQ.........................................................
A0A429RYI5_9ACTN/5-137                 .YLSHEEIQKLTATALEQ..GLANP.MMRNLLFAGILPRYYGALPMLP.APGPQVQSDLNEMNRVERLIDGSVPLALWLRNAADQVTDAAA.RDAF............LGA.LDRVAR.DASG...........EPDVAPRVP.AG-.-ETKEEIVFRDDTVPFAFL-g........................................................
A0A0A8F1W7_9ACTN/4-136                 .YLSPDEILRLRDAALES..GLTDP.GVRPLLFDGIMPRYRGTLPMLA.APMHQLQSDLAQMNQVERLVDGSVPLEIWLRNAVAQTTQAEP.LKVF............QRA.LDEVAR.RAGG...........EPDILADRP.AP-.-EIKEQIVHRDDTVPIGFLR.........................................................
#=GC seq_cons                          .YLss--lhclpcAAl-s..GLADP.uhRshLhsGI.P+apuoLPhhu.uPutQlpoDLspMNcVERLlDGoVPLclWL+NAls.ostsss.hsVF............QRA.LDcVup.pAuG...........-Pcl.ss...ss...EhKEpIlacDDTVPhuFLc.........................................................
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