GenomeNet

Database: Pfam
Entry: Ebola_NP
LinkDB: Ebola_NP
Original site: Ebola_NP 
#=GF ID   Ebola_NP
#=GF AC   PF05505.15
#=GF DE   Ebola nucleoprotein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_8475 (release 8.0)
#=GF GA   25.00 25.00;
#=GF TC   27.90 27.90;
#=GF NC   22.40 22.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0156
#=GF RN   [1]
#=GF RM   9657001
#=GF RT   DNA vaccines expressing either the GP or NP genes of Ebola virus
#=GF RT   protect mice from lethal challenge. 
#=GF RA   Vanderzanden L, Bray M, Fuller D, Roberts T, Custer D, Spik K,
#=GF RA   Jahrling P, Huggins J, Schmaljohn A, Schmaljohn C; 
#=GF RL   Virology 1998;246:134-144.
#=GF DR   INTERPRO; IPR008609;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of Ebola and Marburg virus nucleoproteins.
#=GF CC   These proteins are responsible for encapsidation of genomic RNA.
#=GF CC   It has been found that nucleoprotein DNA vaccines can offer
#=GF CC   protection from the virus [1].
#=GF SQ   10
#=GS A0A2P1GML8_9MONO/9-471   AC A0A2P1GML8.1
#=GS C6G8D3_EBORE/19-734      AC C6G8D3.1
#=GS A0A068J945_9MONO/19-734  AC A0A068J945.1
#=GS A0A091CLL8_FUKDA/1-109   AC A0A091CLL8.1
#=GS NCAP_MABVM/1-691         AC P27588.3
#=GS NCAP_MABVM/1-691         DR PDB; 4W2O H; 632-691;
#=GS NCAP_MABVM/1-691         DR PDB; 4W2Q D; 633-691;
#=GS NCAP_MABVM/1-691         DR PDB; 4W2Q B; 632-691;
#=GS NCAP_MABVM/1-691         DR PDB; 4W2O F; 632-691;
#=GS NCAP_MABVM/1-691         DR PDB; 6APP B; 632-691;
#=GS NCAP_MABVM/1-691         DR PDB; 4W2O B; 632-691;
#=GS NCAP_MABVM/1-691         DR PDB; 4W2Q H; 633-691;
#=GS NCAP_MABVM/1-691         DR PDB; 4W2Q F; 632-691;
#=GS NCAP_MABVM/1-691         DR PDB; 4W2O D; 632-691;
#=GS NCAP_EBOSU/19-734        AC Q5XX08.1
#=GS K4N3C7_9MONO/1-691       AC K4N3C7.1
#=GS NCAP_EBOZM/19-734        AC P18272.2
#=GS NCAP_EBOZM/19-734        DR PDB; 4ZTI B; 38-365;
#=GS NCAP_EBOZM/19-734        DR PDB; 4Z9P A; 36-350;
#=GS NCAP_EBOZM/19-734        DR PDB; 4YPI D; 39-385;
#=GS NCAP_EBOZM/19-734        DR PDB; 4ZTI A; 38-362;
#=GS NCAP_EBOZM/19-734        DR PDB; 4YPI C; 38-385;
#=GS NCAP_EBOZM/19-734        DR PDB; 4QAZ A; 645-734;
#=GS NCAP_EBOZM/19-734        DR PDB; 5T3T A; 113-125;
#=GS NCAP_EBOZM/19-734        DR PDB; 4YPI A; 39-384;
#=GS NCAP_EBOZM/19-734        DR PDB; 5Z9W A; 19-406;
#=GS NCAP_EBOZM/19-734        DR PDB; 4ZTG A; 36-354;
#=GS NCAP_EBOZM/19-734        DR PDB; 4YPI B; 39-385;
#=GS NCAP_EBOZM/19-734        DR PDB; 6NUT A; 20-406;
#=GS NCAP_EBOZM/19-734        DR PDB; 4QB0 A; 645-734;
#=GS NCAP_EBOZM/19-734        DR PDB; 4ZTA A; 37-361;
#=GS G8EFI1_LLOVA/19-746      AC G8EFI1.1
#=GS A0A1Q1NMU1_9MONO/1-693   AC A0A1Q1NMU1.2
A0A2P1GML8_9MONO/9-471              fsdiastpsdsyvsrsklrvyaskapdllygllvaalldpelprs--------------------------------------------------TAASVFVSLFIGHFYRGDITSFSTSSIAKELTKFGHNLiYVEVDIDVASRTIISPKASRLSQYIKKAELLTD-----RTLERFITYLAAMMPKLMISIDAVHAKVVKTDAVLKSQGIPSLGDVLIHKATVTTVRAHLMDSFPGKYLLIKLTISQVSSGSVCGGQIKTLIDQARMAGLVLIKLFTDHLISGSgGKGNkSWHPILSLKDLEREAGDMVAAINGISAHGDLAPFARILGLSGVEKVEYGKFPKLAAVIVGIGQAHNSSLNLMVVGAAHKPLCEAARLFEESRKKDGEAKlgGMFPTQVTQAEKRRLADFHKDMTKATEESLKAAKAAQMRTLQAIRASVGgp.....gsAVGQPKMVTFEDERDEEHHVGNLTVRRRHREYDSDdysySIDQAEYGFDPP.EEDLDDEVDDE...--..----------------.------.---------------------------------.-------...-----..-.....-----.-----....------.-..-------------------------------------.........----------..------------.------........----.....-----....-------------.--------------------------------......------------------------------------------------------------deedeevgpp
C6G8D3_EBORE/19-734                 .............................................LDYHKILTAGLTVQQGIVRQKIISVYLVDNLEAMCQLVIQAFEAGIDFQENADSFLLMLCLHHAYQGDYKLFLESNAVQYLEGHGFKF.ELRKRDGVNRLEELLPAATSGKNIRRTLAALPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKYLLIHQGMHMVAGHDANDAVIANSVAQARFSGLLIVKTVLDHILQKT.DQGV.RLHPLARTAKVRNEVNAFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAESR..ELDSLGLDDQERRILMNFHQKKNEISFQQTNAMVTLRKERLAKLTEAIT.........LASRPNLGSRQDDDNEIPFPGPISNNPDQDHLEDD....PIDSRDTIIPNS.AIDPEDGDFEN...YN..GYHDDEVGTAGDLVLF.DLDDHE.DDNKAFEPQDSS------PQSQRGIERERLIHP.PLGNNKD...DNRASdnN.....QQSAD.SEEQEdrynRHRGPE.R..TTANRRLSPVYEEDTLIDQGDDDPSGPPPLESDDDDA.........SSSQQDPDYT..AVAPPAPVYRSA.EAHEPP........HKSS.....NEPAE....TSQLNEDPDIGQS.KSMQKLEETYHHLLRTQGPFEAINYYHMMKDE......PVIFSTDDGKEYTYPDSLEEAYPPWLTEKERLDNENRYIYINNQQFFWPVMSPRDKFLAI..........
A0A068J945_9MONO/19-734             .............................................MDYHKILTAGLSVQQGIVRQRVIPVYQVNNLEEICQLIIQAFEAGVDFQESADSFLLMLCLHHAYQGDYKLFLESGAVKYLEGHGFRF.EVKKCDGVKRLEELLPAVSSGRNIKRTLAAMPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKT.ERGV.RLHPLARTAKVKNEVNSFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLFPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAESR..ELDHLGLDDQEKKILMNFHQKKNEISFQQTNAMVTLRKERLAKLTEAIT.........AASLPKTSGHYDDDDDIPFPGPINDDDNPGHQDDD....PTDSQDTTIPDV.VVDPDDGGYGE...YQ..SYSENGMSAPDDLVLF.DLDEDD.EDTKPVPNRSTKGGQQKNSQKGQHTEGRQTQST.PTQNVTG...PRRTI..H.....HASAP.LTDND....RRNEPS.G..STSPRMLTPINEEADPLDDADDETSSLPPLESDDEEQ.........DRDGTSNRTP..TVAPPAPVYRDH.SEKKEL........PQDE.....QQDQD....HIQEARNQDSDNT.QPEHSFEEMYRHILRSQGPFDAVLYYHMMKDE......PVVFSTSDGKEYTYPDSLEEEYPPWLTEKEAMNDENRFVTLDGQQFYWPVMNHRNKFMAI..........
A0A091CLL8_FUKDA/1-109              ..........................................mlc----------------------------------------------------------------------------------------.----------------------------------------------------------------------------------------------------------------------------------------------NVLTYIVVNS.NSGT.QIHPTAQGSAIQGEPTQPEHRCRSLQKHVVYASL----YVSLGYQLEHG---QL--LPWGVSSVYPSTLVGANTDACSLALREAANSAELKLQEL----..-------------------------------------------------.........-----------------------------------....------------.-----------...--..----------------.------.---------------------------------.-------...-----..-.....-----.-----....------.-..-------------------------------------.........----------..------------.------........----.....-----....-------------.--------------------------------......------------------------------------------------------------kfkkye....
NCAP_MABVM/1-691                    .............................................MDLHSLLELGTKPTAPHVRNKKVILFDTNHQVSICNQIIDAINSGIDLGDLLEGGLLTLCVEHYYNSDKDKFNTSPVAKYLRDAGYEF.DVIKNADATRFLDVSPNEPHYSPLILALKTLESTESQRGRIGLFLSFCSLFLPKLVVGDRASIEKALRQVTVHQEQGIVTYPNHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLVTGHDAYDSIISNSVGQTRFSGLLIVKTVLEFILQKT.DSGV.TLHPLVRTSKVKNEVASFKQALSNLARHGEYAPFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAHDAEVKLQRRHEHQ..EIQAIAEDDEERKILEQFHLQKTEITHSQTLAVLSQKREKLARLAAEIEnnivedqgfKQSQNRVSQSFLND---PTPVEVTVQARPM-----....---NRPTALPPP.VDDKIEHESTE...DS..SSSSSFVDLNDPFALL.NEDEDTlDDSVMIPG---------------------TTSR.EFQGIPE...PPR--..-.....-QSQD.LNNSQ....GKQE--.-..----------DESTNRIKKQFLRYQELPPVQEDDESEyttdsqesiDQPGSDNEQG..VDLPPPPLYAQE.KRQDPIqhp..aanPQDPfgsigDVNGD....ILEPIRSPSSPSApQEDTRMREAYE------------LSPDFTNDEdnqqnwPQRVVTKKGRTFLYPNDLLQTNPPESLITALVEEYQNPVSAKELQADWPDMSFDER-RHV..........
#=GR NCAP_MABVM/1-691         SS    .............................................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXX-----....---XXXXXXXXX.XXXXXXXXXXX...XX..XXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXX---------------------XXXX.XXXXXXX...XXX--..-.....-XXXX.XXXXX....XXXX--.-..----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXX.XXXXXXXXX..XXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXX------------XXXXXXXXXXXXXXSSEEEE-TTS-EEEETGGGSSSS--HHHHHHHHHTSS-HHHHHHHHHHGGGS-HHHH-HHH..........
NCAP_EBOSU/19-734                   .............................................LDYHKILTAGLSVQQGIVRQRVIPVYVVSDLEGICQHIIQAFEAGVDFQDNADSFLLLLCLHHAYQGDHRLFLKSDAVQYLEGHGFRF.EVREKENVHRLDELLPNVTGGKNLRRTLAAMPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTSWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDTVISNSVAQARFSGLLIVKTVLDHILQKT.DLGV.RLHPLARTAKVKNEVSSFKAALGSLAKHGEYAPFARLLNLSGVNNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAETR..ELDNLGLDEQEKKILMSFHQKKNEISFQQTNAMVTLRKERLAKLTEAIT.........TASKIKVGDRYPDDNDIPFPGPIYDETHPNPSDDN....PDDSRDTTIPGG.VVDPYDDESNN...YP..DYEDSAEGTTGDLDLF.NLDDDD.DDSQPGPP---DRGQSKERAARTHGLQD-PTLD.GAKKVPE...LTPGS..HqpgnlHITKP.GSNT-....--NQPQ.GnmSSTLQSMTPIQEESEPDDQKDDDDESLTSLDSEGDED.........VESVSGENNP..TVAPPAPVYKDT.GVDTNQ........QNGP.....SNAVD....-GQGSESEALPINpEKGSALEETYYHLLKTQGPFEAINYYHLMSDE......PIAFSTESGKEYIFPDSLEEAYPPWLSEKEALEKENRYLVIDGQQFLWPVMSLQDKFLAV..........
K4N3C7_9MONO/1-691                  .............................................MDLHSLLELGTKPTAPHVRNKKVILFDTNHQVSICNQIIDAINSGIDLGDLLEGGLLTLCVEHYYNSDKDKFNTSPIAKYLRDAGYEF.DVIKNADATRFLDVIPNEPHYSPLILALKTLESTESQRGRIGLFLSFCSLFLPKLVVGDRASIEKALRQVTVHQEQGIVTYPNHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLVTGHDAYDSIISNSVGQTRFSGLLIVKTVLEFILQKT.DSGV.TLHPLVRTSKVKNEVASFKQALSNLARHGEYAPFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAHDAEIKLQRRHEHQ..EIQAIAEDDEERKILEQFHLQKTEITHSQTLAVLSQKREKLARLAAEIEnnivedqgfKQSQNRVSQSFLND---PTPVEVTVQARPV-----....---NRPTALPPP.VDDKIEHESTG...DS..SSSSSFVDLNDPFALL.NEDEDTlDDSVMIPS---------------------TTSR.EFQGIPE...SPG--..-.....-QSQD.LDDSQ....GKQE--.-..----------DESTNPIKKQFLRYQELPPVQEDDESEyttdsqesiDQPGSDNEHG..VDLPPPPLYTQE.KRQDPIqhp..aasSQDPfgsigDVNGD....ILEPIRSPSSPSApQEDTRAREAYE------------LSPDFTNYEdnqqnwPQRVVTKKGRTFLYPNDLLQTSPPESLVTALVEEYQNPVSAKELQADWPDMSFDER-RHV..........
NCAP_EBOZM/19-734                   .............................................MDYHKILTAGLSVQQGIVRQRVIPVYQVNNLEEICQLIIQAFEAGVDFQESADSFLLMLCLHHAYQGDYKLFLESGAVKYLEGHGFRF.EVKKRDGVKRLEELLPAVSSGKNIKRTLAAMPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKT.ERGV.RLHPLARTAKVKNEVNSFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLFPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAESR..ELDHLGLDDQEKKILMNFHQKKNEISFQQTNAMVTLRKERLAKLTEAIT.........AASLPKTSGHYDDDDDIPFPGPINDDDNPGHQDDD....PTDSQDTTIPDV.VVDPDDGSYGE...YQ..SYSENGMNAPDDLVLF.DLDEDD.EDTKPVPNRSTKGGQQKNSQKGQHIEGRQTQSR.PIQNVPG...PHRTI..H.....HASAP.LTDND....RRNEPS.G..STSPRMLTPINEEADPLDDADDETSSLPPLESDDEEQ.........DRDGTSNRTP..TVAPPAPVYRDH.SEKKEL........PQDE.....QQDQD....HTQEARNQDSDNT.QSEHSFEEMYRHILRSQGPFDAVLYYHMMKDE......PVVFSTSDGKEYTYPDSLEEEYPPWLTEKEAMNEENRFVTLDGQQFYWPVMNHKNKFMAI..........
#=GR NCAP_EBOZM/19-734        SS    .............................................XXSTHHHHTTTSXXXXXXS-EEEEEEE-S-HHHHHHHHHHHHHHT---GGGHHHHHHHHHHHHHSTT-HHHHHHSHHHHHHHHTTEEE.EEEE-TS-SSGGGCS-SHTTHHHHHHHHHHS-SS---S--HHHHHHHHHTTTTTTTT-HHHHHHHHHHHHHHHHHTTS----GGGGSHHHHHHHHHHHHH-HHHHHHHHHHHHTS-SSS-HHHHHHHHHHHHTTTTTTHHHHHHHHHHEEEE.TTEE.EE-GGGGSGGGHHHHHHHHHHHHHHHGGGGGGGGHHHHT-TTGGGG-GGGSHHHHHHHHHHHHHCTTTGTT--HHHHHHHHHHHHHHHHHHHHHHHHHH..HHHHSSXTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHXXXXX.........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXX.XXXXXXXXXXX...XX..XXXXXXXXXXXXXXXX.XXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXX...XXXXX..X.....XXXXX.XXXXX....XXXXXX.X..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.........XXXXXXXXXX..XXXXXXXXXSXX.XXXXXX........XXXX.....XXXXX....XXXXXXXXXXXXX.XXXHHHHHHHHHHHHHCXHHHHHHHHHHHHXS......XEEEEXTTSXEEEETGGGSSSSXTTSXCCHHHSGGGGEEEETTEEEEGGGXXHHHHHHHH..........
G8EFI1_LLOVA/19-746                 ............................................s-ELHGILSLGLNVDHTIVRKKSIPLFEIGNSDQVCNWIIQIIEAGVDLQDVADSFLTMLCVNHAYQGDPNLFLESPAAHYLKGHGIHF.EIQHRDNVDHITDLLGVGSRDKSLRKTLSALEFEPDGSTTAGMFLSFASLFLPKLVVGERACLEKVQRQIQIHAEQGLIQYPTQWQSVGHMMVVFRLIRVNFVLKFLLVHQGMHMMAGHDANDAIIANSISQTRFSGLLIVKTVLEHILQKT.EAGV.QLHPLARTSKVKGELLAFKSALEALASHREYAPFARLLNLSGVNNLEHGLYPQLSAIALGVATAHGSTLAGVNVSEQYQQLREAATEAEKQLQQHSEMR..ELETLGLDEQERKILATFHSRKNEINIQQTSSILAIRKERLRKLTEALNee.....knKNALDD-EDESEEDDWSPENRGIRSNKGSTKESSS....YTASRTEEDRNN.YNSKDDHLSGK...EQ..MSTQQE-SGADDLDLF.DLDDDG.DTNSQDPN---NRQKQSDTQQTQESSDRSDYSRrPAYDWPPgdrPHTTQ..A....tDEHTDlLNKDH....RRNQVKpGrrGNDPRTLPLISFDDNEG-EILDDKSDLPAPDTH-SDP.........DTEESEEEHPdeELLPPAPKYNTK.TSEQE-........PGDW.....KQPTSplstIPEEEGGHEANNDnSESDLIDQMYQHIFETEGAYAAINYYYKTTGR......PVTFTSNNNHDYTFPQDIEGLFPPWEGKENQKVAEILTNSLHETGQEWADMSAKERY---lfl.......
A0A1Q1NMU1_9MONO/1-693              .............................................MDLHGLLELGTRPTAPHVRSRKIVIYETGNQIIICNQIIDAVSAGIDLGDLLEGCLLTLCLEHYYGSDKDKFNSSQMAAYLRDAGYDF.EVIRAQDAKKLADLIPRESHLLNVISALENLDGSEKNKQRVGLFLSFCSLFLPKLVVGDKASIEKALRQVAIHQEQGMVVYPPTWLTTGFMKLIFSIVRASFIVKFVLIHQGINLVTGHDAYDNVISNSINQTRFSGLLIVKTVLEHILQRT.ENGV.ILHPLVRTSKVKSEVESFKVALRGLARHKEYAPFARVLNLSGVNNLEHGLFPQLSAIAIGVATAHGSTLAGVSVGEQYQQLREAAHDAELKLQRRREQM..EISSLELDLEEQKILEQFHQQKTEITHTQTLAVLTQKKEKLAKLAGELG.........ADKLFQPVIPQPND--KPQMTTVIDPSRTS-----....-VKIQTSFLPPPsTKDNMEGQIPEspeSStiSSSSSCIDPNDPFALLiDDDEQE.GDFQSADE----GDSQDQSAEAARQEEIRKAEQ.KFKGLP-...--RTI..P.....TKDQN.PPIKP....QRTN--.-..------LAPVQEESES------EYT-----TTSDESG.........SEDESSDQRN..IEVPPPPLYDTStSEIGDMgaaehtldP--Fgd.mpPLETD....VLTPQDTATVPSA.PPSSPTPSTNR-----QGEAQTQNGEDSSQDW......PRRVKTNKGREFMFPTDLLHRTPPQVLLDALVNEYESPLSATELSDDWPEMTFEER----knv.......
#=GC SS_cons                        .............................................XXSTHHHHTTTSXXXXXXS-EEEEEEE-S-HHHHHHHHHHHHHHT---GGGHHHHHHHHHHHHHSTT-HHHHHHSHHHHHHHHTTEEE.EEEE-TS-SSGGGCS-SHTTHHHHHHHHHHS-SS---S--HHHHHHHHHTTTTTTTT-HHHHHHHHHHHHHHHHHTTS----GGGGSHHHHHHHHHHHHH-HHHHHHHHHHHHTS-SSS-HHHHHHHHHHHHTTTTTTHHHHHHHHHHEEEE.TTEE.EE-GGGGSGGGHHHHHHHHHHHHHHHGGGGGGGGHHHHT-TTGGGG-GGGSHHHHHHHHHHHHHCTTTGTT--HHHHHHHHHHHHHHHHHHHHHHHHHH..HHHHSSXTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHXXXXX.........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXX.XXXXXXXXXXX...XX..XXXXXXXXXXXXXXXX.XXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXX...XXXXX..X.....XXXXX.XXXXX....XXXXXX.X..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.........XXXXXXXXXX..XXXXXXXXXSXX.XXXXXX........XXXX.....XXXXX....XXXXXXXXXXXXX.XXXHHHHHHHHHHHHHCXHHHHHHHHHHHHXS.....SSEEEEXTTSXEEEETGGGSSSSXTCCHCCHHHCCCCGCCCCCCCCCCGGGSXHHHHHHHH..........
#=GC seq_cons                       .............................................hDhHplLphGhpsptshVRp+hIslapsss..tICp.IIpAhpAGlDht-sA-ShLLhLClcHhYpGDhchF.pSsss+YLcsaGacF.EVp+pssVpRlp-LlPssophpslh+sLtsLsppEoscussG.FLSFsSLFLPKLVVG-+AslEKV.RQlpVHtEQGllpYPssW.osGHMhVIFplhRosFllKFLLIHQGhphVuGHDAsDulISNSVuQsRFSGLLIVKTVL-HILQKT.-pGV.pLHPLARTuKVKNEVsSFKuALuuLA+HGEYAPFARlLNLSGVNNLEHGLaPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAs-AEcpLQphuEp+..ElpsLuLD-pE+KILhsFHpcKsEIoapQTpAhloh+KE+LAKLstuIs.........tsShs+susp.s-Ds..PhPsslsspscss..pss.....hcspsTslPss.ssD..Dtp.sc....p..u.opsthsssDshsLh.s.D-Ds.-Dsp.hPs...........ttttt..t..stpp..hpslPt...s.ps.........ptots.hspsp....t+pp............hs.lpE-ss.hcpt..-hppLPslpo-D-pt.........spstosscps..sshPPsPlYpsp.pppp..........sps......p.ssD....hhp.tcs.sssss.ppppthcEhYc.....pG.hts..h.chhpDE......PhhhsTpcG+-ahaPssL.pthPP..h.cthhpc.pp.lohct.Qh.WPsMohc-+.htl..........
//
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