GenomeNet

Database: Pfam
Entry: Endonuc-HincII
LinkDB: Endonuc-HincII
Original site: Endonuc-HincII 
#=GF ID   Endonuc-HincII
#=GF AC   PF09226.14
#=GF DE   Restriction endonuclease HincII
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1xhv
#=GF GA   23.70 23.70;
#=GF TC   23.90 41.60;
#=GF NC   22.50 23.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   15476804
#=GF RT   Mechanistic insights from the structures of HincII bound to
#=GF RT   cognate DNA cleaved from addition of Mg2+ and Mn2+. 
#=GF RA   Etzkorn C, Horton NC; 
#=GF RL   J Mol Biol. 2004;343:833-849.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR015307;
#=GF DR   SCOP; 1xhv; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family of prokaryotic restriction endonucleases
#=GF CC   recognise the double-stranded sequence 5'-GTYRAC-3' and cleave
#=GF CC   after Y-3. They catalyse the endonucleolytic cleavage of DNA to
#=GF CC   give specific double-stranded fragments with terminal
#=GF CC   5'-phosphates [1].
#=GF SQ   11
#=GS A0A1M5DZ88_9BURK/8-254  AC A0A1M5DZ88.1
#=GS A0A5C8GLY8_9BACT/9-258  AC A0A5C8GLY8.1
#=GS A0A2S4N642_9FLAO/8-254  AC A0A2S4N642.1
#=GS G2Z2I3_FLABF/8-254      AC G2Z2I3.1
#=GS A0A4R2N5G8_9PAST/8-254  AC A0A4R2N5G8.1
#=GS I4Z8Y2_9BACT/7-258      AC I4Z8Y2.1
#=GS I4AID7_BERLS/9-255      AC I4AID7.1
#=GS C7M7J0_CAPOD/8-254      AC C7M7J0.1
#=GS T2D2_HAEIN/11-257       AC P44413.2
#=GS A0A1B8QG36_9GAMM/8-254  AC A0A1B8QG36.1
#=GS N0BLE5_9EURY/14-282     AC N0BLE5.1
A0A1M5DZ88_9BURK/8-254             ..............LAESIQGTSVPKPA...SGTLSGHAAGEPFDKHVYAELKRQFPDNAYRQYEYLNDLYSRNPSV.IGFRARQELFDS...PTVLFLLSRGK..NATDQWNIE.NPFDEKQNDTADILV.....AKNGFYEI..IDIKTRNISKKAQPPNIISAFKLAQVCARMLDNQD..YDRFAIHYFEVDW..ELEGDRLVCRHASSACLFKAQPSDL.YINWAAAMQIQFHVRDLDQGFDGSM....QDWAVVYLKHFVEQAKKRADDMIKKFVIPFEKYI..............
A0A5C8GLY8_9BACT/9-258             ............lt--KGMKNQRVERPNkasAGTLSGHAAGEPFEKCVYKILKQKYPNNIFKQYEYLNDIYLRHPKH.ITVEQKYALFDS...PTALFLLNRGN..KATKEWTPE.NLFEEKQNDTADILY.....HEPNYYGI..IDVKTRNIDKSAMAPNIVSAYKLARMCALMIDNEE..FDTLGIDYIEIDW..TEEEKHLRCTDAHYANLFKAKPEAL.YINWSAALQIQFHVCDLDQSWSGTM....EEWARHYLKVFVDSAETRMVMMREKFIEPFRKYI..............
A0A2S4N642_9FLAO/8-254             ..............LAKNLKGTSVPKPL...SGTLSGHAAGEPFDKHVYAEIKKQFPKNTFRQYEYLNDLFSKNPNV.IGFQARQALFNS...PTVLFLLSRGK..NATDKWSIE.NPFDEKQNDTADILV.....VKDGFYEI..IDIKTRNISKSAQPPNIISAFKLAQVCAKMIENKE..FNDFTINYFEIDW..LLDNDKLVCYDTHFACLFKAQPGNL.YINWAAAMQIQFHVSDLDQSFNGSM....ESWAKSYLKHFVAQAKKRADDMITKFVMPFEKYI..............
G2Z2I3_FLABF/8-254                 ............li--KNLKGAFVPKPL...SGTLSGHAAGEPFDKHVYNEIKKQLPNCTFRQYEYLNDLYTQNSDV.IGYEAREKLFKS...PSVHFLLARGK..DVTNKWSSE.NPFDEKQNDTADILV.....VKDNFYEI..IDIKTRNLSKSAQPPNIISAFKLAQVCSKMIDNKE..YDKFTINYFEIDW..ELNKEKLVCKDAHFASLFRCNPSNL.YINWAAAMQLQFHICDLDQEFKGNL....EEWAVAYLKHFVAQAKKRASDMITKFVIPFEKYI..............
A0A4R2N5G8_9PAST/8-254             .............l-KPKLLGLSIPKPL...SGTLSGHSAGEPFDKLVYQKVKEDFPENTFRQFEYLNDLFSKNPMV.IGVEGRLALFNS...PTIMFLLSRGK..DAMDKWSIE.SPFEEKQNDTADILL.....VKDNFYQI..IDIKTRNLGKKAQAPNIISAYKLAQVCAKMLDNQE..FDNFTINYLEIDW..RLDNDRLVCQDVHFMDLFKSDPSTL.YINWAAAMQIQFHTCDMEQTFLETK....EQWAKSYLKHFVEQAKRRASEMINKFVTPFEKYI..............
I4Z8Y2_9BACT/7-258                 ............li--RQLKGKRVPRPNrieNGTLSGHAAGEPFEKETYRILKKTYLCEIFKQHEFLNDLFLRNTRS.ITIEQKHKLFDS...PTAFFLLSRSD..AATKKWSEN.NLFEEKQNDTADILY.....IKDGFYNI..IDVKTRNVNKNAQPPNIISAFKLAQMCAYMIDNDD..YLTVNIDYIQIDWceQSKHDYLECVNAYHANLFKVDPNSL.YINWAAAMQIQFHVNEVDQTFIGTK....KEWCYLYIKHFVASANMRISNMREKFIKPFIKYI..............
I4AID7_BERLS/9-255                 ..............LKNKVIGSKVSKPL...SGTLSGHAAGEPFDKHVYAELKKEFPQQTFRQYEYLNDLYSKNPKV.ITFQERLNLFNS...PTVMFLLSRGK..QATSKWDLE.NIFEEKQNDTADILV.....VKNDFYEI..IDIKTRNTSKKSQPPNIISAYKLAQTCAKMLDNKE..YDSFSICYFGIDW..KLEGNFLVCIDAHSVNLFKSNPQDL.YINWAAAMQIQFQVDNLEQNFEGNQ....EEWARQYLKHFITQAKRRAENMIEKFVKPFEKYV..............
C7M7J0_CAPOD/8-254                 ..............LAKSLKGTTVPKPL...SGTLSGHAVGEPFDKHVYTEIKKQCPKNTFRQYEYLNDLYSNNPSV.IGFKSREALFNS...PTVLFLLSRGK..NATDKWSLN.NPFEEKQNDTADILV.....VKDEFYEL..VDVKTRNIAKKAQAPNIISAYKLAQLCAKMLDNEE..FDNFTINYFEVDW..LLENDKLICKDTHFGCLFKENPEEL.YINWAAAMQIQFHVSDLDQLFKGNK....KQWAQRYLKHFVTQAQKRADDMIIRFVKPFEKYI..............
T2D2_HAEIN/11-257                  ..............INSILIGQKVKRPK...SGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKKPAI.IGHEARYKLFNS...PTLLFLLSRGK..AATENWSIE.NLFEEKQNDTADILL.....VKDQFYEL..LDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKE..FDLFDINYLEVDW..ELNGEDLVCVSTSFAELFKSEPSEL.YINWAAAMQIQFHVRDLDQGFNGTR....EEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYI..............
A0A1B8QG36_9GAMM/8-254             .............l-RQQLIGQSIPKPI...TGTLSGHAAGEPFDKLVYNTLKTLLPNQTFRQYEYLNDLYAKNPTT.IGYDGRMMLFNS...PSVLFLLSRGK..NATDRWSPN.NLFEEKQDDTADILV.....VDNGFFEI..IDIKTRNLAKTAQPPNIISAYKLAQLCSIMLDNQE..FDNLSINYIEIDW..ALQTDRLVCQAAFHANLFKSNPQNL.YINWAAGMQIQFHVCNLDQSFGGDN....EQWAKSYLKHFVARVYQRSAYMIAKYAKPFEKYI..............
N0BLE5_9EURY/14-282                lstakgqvvndvai--------------...MSRASGSASGLPFEEWTKNKLN-ECGFKTFLQEEYLLEVVRELKEKgHSNSQIERIIRDtwwGTSNYMISRNQlnHAFNQHALNqNDPPAYQQSIADIILfygndLVDNINDIvaINVKSHNLDRPSRDPNIISAKRIIDYMKDILETKPsiIDKVNLWFIGIYY..RQSSGYASIEEIYIKDFFRLDVKKIpTINFDAAIQIQWHVKDMVELESQDKltfiESLAEEFNKRWVEFVDRRTASI------------eetlntlrtlikky
#=GC seq_cons                      ...............tppLhGppVPKPh...SGTLSGHAAGEPFDKpVYscLKcphPppTFRQYEYLNDLas+NPpl.IGacuR.tLFsS...PTlhFLLSRGK..sATc+WSlE.N.FEEKQNDTADILl.....VKDsFYEI..IDlKTRNluKsAQsPNIISAaKLAQhCA+MlDNcE..aDsFsIsYhEIDW..pLcs-+LVCp-saaAsLFKusPpsL.YINWAAAMQIQFHVsDLDQsFpGsp....EpWAcpYLKHFVsQAc+RAssMIpKFVpPFEKYI..............
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