#=GF ID   Endotoxin_C
#=GF AC   PF03944.21
#=GF DE   delta endotoxin
#=GF PI   endotoxin_C; 
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   de Maagd R;
#=GF SE   Arne Eloffson
#=GF GA   21.00 21.00;
#=GF TC   21.00 21.10;
#=GF NC   20.90 20.80;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Delta_endotoxin
#=GF CL   CL0202
#=GF RN   [1]
#=GF RM   1658659
#=GF RT   Crystal structure of insecticidal delta-endotoxin from Bacillus
#=GF RT   thuringiensis at 2.5 angstroms resolution. 
#=GF RA   Li J, Carroll J, Ellar DJ; 
#=GF RL   Nature 1991;353:815-821.
#=GF RN   [2]
#=GF RM   9729609
#=GF RT   Bacillus thuringiensis and its pesticidal crystal proteins. 
#=GF RA   Schnepf E, Crickmore N, Van Rie J, Lereclus D, Baum J, Feitelson
#=GF RA   J, Zeigler DR, Dean DH; 
#=GF RL   Microbiol Mol Biol Rev 1998;62:775-806.
#=GF DR   INTERPRO; IPR005638;
#=GF DR   SCOP; 1dlc; fa;
#=GF DR   HOMSTRAD; endotoxin;
#=GF DR   TC; 1.C.2;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This family contains insecticidal toxins produced by Bacillus
#=GF CC   species of bacteria.  During spore formation the bacteria
#=GF CC   produce crystals of this protein.  When an insect ingests these
#=GF CC   proteins they are activated by proteolytic cleavage.  The N
#=GF CC   terminus is cleaved in all of the proteins and a C terminal
#=GF CC   extension is cleaved in some members.  Once activated the 
#=GF CC   endotoxin binds to the gut epithelium and causes cell lysis
#=GF CC   leading to death.  This activated region of the delta endotoxin
#=GF CC   is composed of three structural domains.  The N-terminal helical
#=GF CC   domain is involved in membrane insertion and pore formation. 
#=GF CC   The second and third domains are involved in receptor binding.
#=GF SQ   29
#=GS Q7BE98_BACTU/471-608        AC Q7BE98.1
#=GS A0A917K722_9BACL/717-854    AC A0A917K722.1
#=GS A0A1M4X014_9GAMM/594-708    AC A0A1M4X014.1
#=GS A0A8J3GGG6_9HYPH/1848-1964  AC A0A8J3GGG6.1
#=GS C0ZKJ5_BREBN/469-615        AC C0ZKJ5.1
#=GS A0A563VQB0_9CYAN/49-186     AC A0A563VQB0.1
#=GS A0A1M4WTG5_9BACT/38-173     AC A0A1M4WTG5.1
#=GS A0A1P8U5I2_9MICO/736-854    AC A0A1P8U5I2.1
#=GS M9LFB4_PAEPP/565-700        AC M9LFB4.1
#=GS A9FKB6_SORC5/41-169         AC A9FKB6.1
#=GS A0A386HS42_9BACT/389-533    AC A0A386HS42.1
#=GS L8M0Z4_9CYAN/1213-1346      AC L8M0Z4.1
#=GS A0A926SQM0_9CYAN/352-481    AC A0A926SQM0.1
#=GS X7FAL4_9RHOB/1739-1860      AC X7FAL4.1
#=GS A0A5D0VUK4_9RHOB/1767-1887  AC A0A5D0VUK4.1
#=GS L8LSM8_9CYAN/722-855        AC L8LSM8.1
#=GS F0ZWB2_DICPU/506-616        AC F0ZWB2.1
#=GS Q54HS7_DICDI/501-628        AC Q54HS7.1
#=GS D3VLZ6_XENNA/496-652        AC D3VLZ6.1
#=GS A0A3N6NRG0_9CYAN/27-153     AC A0A3N6NRG0.1
#=GS L8M7W2_9CYAN/707-839        AC L8M7W2.1
#=GS L8MB10_9CYAN/291-414        AC L8MB10.1
#=GS M9LC08_PAEPP/592-727        AC M9LC08.1
#=GS A0A0D3V5M4_9BACL/516-646    AC A0A0D3V5M4.1
#=GS A0A7U3ZLJ6_RUNSL/8-82       AC A0A7U3ZLJ6.1
#=GS A0A9P9J9J5_9HYPO/23-140     AC A0A9P9J9J5.1
#=GS A0A926X0F8_9CYAN/5-134      AC A0A926X0F8.1
#=GS A3RLZ7_BACTU/499-636        AC A3RLZ7.1
#=GS A0A1S8TW68_9CLOT/491-622    AC A0A1S8TW68.1
Q7BE98_BACTU/471-608                   ...........................ITQIPLTKSTNL.GSGTSVVKGPGFTGGDIL.-RRTSPGQ...ISTLRVN.IT.APLSQRY.RVRIRY..A..S..T....T.N.LQ..F.HTSI..D.GRPIN......QGNFSATMSSGSN......LQ--..SGS..FRTVGFTT..........PFNFSNGS-SVFTLSAHVFNSG..NEVYIDRIEFVPA-e...............................
A0A917K722_9BACL/717-854               ........................aes-------KKNSL.GGIARVLSDPHASGGKYV.ALTANTKG...SSNIKFNdIH.VPESGLY.RLVIRY..S..N..G....E.F.VD..A.NGGV..N.SYNLNvvdcaaDISVNGGASKRVY......FR--..-NT..YADNNFWTt.......vmDVYLRKGM-NTIEF--SNKHS-..GALNIDNIQ-----ia..............................
A0A1M4X014_9GAMM/594-708               .......................glrp------------.----------DYSGSGYL.DFGSKPGD...VVTFTIE.--.VTEGGSY.DLNVRY..A..S..N....G.D.RP..L.ALSV..N.EGGAS......NVPFPGTDPDGSG......ELEG..FDN..WEYVTVPV..........TLNAGEN---TIALAIPSGAS-..KGPNLDRVEI----t...............................
A0A8J3GGG6_9HYPH/1848-1964             ................lrpdysgtgyl------------.------------------.DFGDFPGD...SVTFTVT.--.VSEAGTY.DLNVRY..A..S..V....N.E.RP..L.SLSV..N.NGTVS......TMPFPDTSVPAQN......GQPA..IEG..FNNWEFST.........vGVQLVAGV-NTITLAIPA-GAN..TGPNIDRIEL----t...............................
C0ZKJ5_BREBN/469-615                   ...........................IKGIPAEKGYIEdGSSLKVVQ-ERLNGTNAV.QLPLGPSL...--VVPIT.--.NKLAGQY.HIRVRY..A..N..P....S.D.SS..I.DIWQ..S.VNAGKqtiqggNFTFPSTKNVQDQg....yVPGQ..NGN..YRLLTISLp........dPISLPLGE-IDVRLGQYTSQTQ..GNLFIDRIEFVPVQ................................
A0A563VQB0_9CYAN/49-186                .........tveaesmqlggeykveti------------.----------GAASGNKV.ISLRGGMI...EGKGAAK.FNfNGASGNY.NVKIHY..F..D..E....N.D.GV..G.KFNL..K.QGTQQi....aSVNLNKQLGS--S......LA-N..GQT..LTTTEVKN..........-VSIKAGDNFTLEG-FEDGTANtaEHVRVDKIEFIPT-s...............................
A0A1M4WTG5_9BACT/38-173                ................vvtrnatdnti------------.-IEAKLSSGIRITGGDIT.SCSPGDAI...LVTYKVN.FN.-NYIDET.TIRADY..A..T..I....A.S.GD..R.FLSA..S.QKRIV......ESPFTQTPTEDNSftginnPSGS..YDQ..YFLDRWIT..........TIGAQVQSDQNISFELYYNEDN..Q-------------glen............................
A0A1P8U5I2_9MICO/736-854               ....................aeatgnt-----------R.SGTAAVTSCSGCSGGSAV.SGLNSTGT...LVFTSQS.--.VAASGNH.TVRLDY..A..S..A....S.A.QT..V.QVSV..N.GGSPK......TVTLPTTGSATAT......AT--..---..--------..........----------------------..--------------ktlglqlsagtntiqlsgassaavaidklsvv
M9LFB4_PAEPP/565-700                   ..........................f-TISPLHLTSFThPSEAHIQENYG-NSGDSL.RIYSLSSS...TLNLYYT.LS.GNGQDRY.NIVLRI..S..G..Q....A.G.NV..V.VYVD..G.AWRGA......TLPFMTTNNN-EG......VTDN..DSQ..FKDFFLQN..........PFVLKEQSQLLLSI-----STP..RNLDIMNIILLPVN................................
A9FKB6_SORC5/41-169                    ......avrieaenqswstspgdkied------------.-------------NADNV.KLRANQSG...-DTFKFS.-A.SVASGTY.KIVLRY..A..T..-....R.N.VY..G.KYEL..A.VKGSS......VKSFDAYGS----......ST--..GDS..WTTATLGE..........-KSLSGNVEFSLTCKGKSSSSS.gYDLKVDYIELVPV-g...............................
A0A386HS42_9BACT/389-533               ....................dpgpaap------------.---SYVYGGAPFVNGDYL.KIPLGANR...TPWVELK.TP.LLVQGKY.KVWICY..R..T..A....G.R.DN..VdQVSI..D.GVALQ.....rTINHHTYMPSGTD......AERE..AQG..WKVYTSPDqknwtgylvgTIDIQTTSQHALR--FTNLQGT.dNDFWLDMIEFIPVD................................
L8M0Z4_9CYAN/1213-1346                 ....................tvsqgdi------------.--NDFIVKGDAHTGFASL.QLKPNLTL...KKQTALT.-I.TNTQQSY.IISAWF..K..T..E....T.G.FE..T.DGGK..A.EVKL-......--QFYNGNNSVGNpi.tasIKST..DSK..WKYWHY--..........AISSEQIQGTNLGLEISNQKTS..KSLLIDDICFIPL-m...............................
A0A926SQM0_9CYAN/352-481               ..................evedlsldt------------.---YQVERNSVASGGALV.SLRNASGN...IGKVSTE.-F.TTVSGFY.DVVITY..LdeT..D....G.A.AK..L.DFQV..D.GRSID......AWTLDKNLGSSDP......VE--..-QT..FTKRTISN..........-VALKQGD--TLSL-VGNYDGG..EWARVDSIELVPVD................................
X7FAL4_9RHOB/1739-1860                 ...................npaletgl------------.--------RPDFTGTGYL.DFGNDAGD...--TFTVT.VD.VPAAGSY.DLNVRY..A..S..S....T.D.RP..L.DLSV..N.GGTAT......TMPFVSTDPDGPS......GP--..ADG..FDIWLYST.........vTVTLEAGS-NTVSLAIPAGLT-..SGPNIDRIEI----t...............................
A0A5D0VUK4_9RHOB/1767-1887             ................pesnsslpngl------------.--------RPDFTGDGYL.DFGNDAGD...TVTYSVT.--.VQEAGTY.EIAVRY..A..T..S....T.D.RP..L.DFVL..N.GAAPV......QLPFVSTDPDG--......-AGP..EDG..FDYWEIET.........vSVELVAGE-NTFSFAI------..--------------pagtntgpnldai...................
L8LSM8_9CYAN/722-855                   ..................rieaedlsw------------.SGNYKVMKKNFASGGRLI.KNKNNNQA..iAGTTTF-.--.TGETGTY.KIIIGY..H..DidL....K.T.GE..I.QFKL..N.DNLID......SWQLNKDIDGNK-......--PS..SEN..FTTHTIEN..........-ISLTKNQFFTIQN-IVSSDKG..GEGSLDYIEFVPV-v...............................
F0ZWB2_DICPU/506-616                   ......................amfmp------------.------------------.---AKSSI...VFRFTYK.NT.NTTVTKY.NVGVRY..H.fS..G....G.Q.AT..A.SIVV..K.KPDNEd...kgTIALAKCSKSADN......NG--..FNE..YKIALLNQ..........TINFANFSERQITL-----KAN..NNLYLHSIILIPS-k...............................
Q54HS7_DICDI/501-628                   ....vqkarfiddskfakdhvaptihs------------.-----------------I.KVANDGQA...IFDIELL.-P.NNTVRKY.SFGIRY..H..C..T....Q.D.SE..V.ILFD..GpEEDGN......YLPLEKCSTS---......-G--..YNQ..YKIKLFPN..........KFIIFEPNSNSTYVTIQAKS--..QTLYIESIILLPK-q...............................
D3VLZ6_XENNA/496-652                   ............itsskynkdneihpl------------.-DRDSIISNLGFSQGAVV.RIRKDERIiflLAKSDLE.PNrWIFPGDY.KIRLWH..I..K..V....K.N.AK..V.NISI..S.QTDGKgnvdchSINMELNNHDMKD.....dIEDEyiYSDlcFKQTDNHH..........DFVIKDNI-YQINILIKNIST-..NKVIIDRIELIPV-f...............................
A0A3N6NRG0_9CYAN/27-153                ............dmtlsgyksesrsva------------.-------------SGDAVvSVSRKHTQ..gSATTQFT.--.-GDTGTY.NVVVGY..Y..D..E....K.D.GQssV.SVEI..G.NQTID......SSVFDQDLGN-SS......VS--..SKN..FVERTIAT..........SLQINNGE--NITLNGEKEGG-..ERARFDYIEFIPV-a...............................
L8M7W2_9CYAN/707-839                   ..................veaedmsws------------.-GKYKVKNKSFASGGSLI.QYDDEDKW..fSGSMNFS.--.-GQAGTY.NIIIGY..H..DieE....A.N.GQ..I.IVEL..N.GTSIA......SWNLTKNIGE--E......IG--..AGN..FTTHTINN.........iPLTV--NDSLNLQSIINYDDEG..GEGSIDYIEFVPV-v...............................
L8MB10_9CYAN/291-414                   ............aesmnlsggyypddd------------.-----------FYHGEVI.RTSSDNPS..gVAKNEFT.--.-GENGYY.QVKVRYidE..S..D....G.N.AS..L.RVKI..G.DAEID......SWILEQNEEG---......----..ENQ..YHTRTISQ..........GMHIDTNAAIEIQGQAENYEFA..---RVDYIEFIPIE................................
M9LC08_PAEPP/592-727                   ..........................f-TISPLHLDTVNiNSYLYIQENYG-NNGDSL.RVINRAI-...-IKYRLS.--.AARSVIY.RLVLRV..S..G..T....A.S.SI..V.AIYE..N.YPVGSa....nQINTGTDNEG---......VIDN..DSK..FIDLIFNT..........PFSVSGTA-RELQLQVSGATTS..SPLDIMNIILIPIN................................
A0A0D3V5M4_9BACL/516-646               ...........................ITQVSAVKASTS.-SNCTVISGPGFTGGDLV.RLHSNGQF...VIQFQVP.--.-TPQTNY.RIRIRY..A..S..T....F.G.CS..I.NIIF..N.DGAH-......LSTLPSTASSLEN......LQ--..YNN..LSYFNVNG..........TFKPSMGN----SLTIVNTSSN..SNLVIDKIEFIPEN................................
A0A7U3ZLJ6_RUNSL/8-82                  .................lafilfscnq------------.------------------.--------...-------.--.-------.------..-..-..-....-.-.--..-.----..-.--NED......ITKYTSTFNANDI......-VLE..NED..FVITSDKD..........RIRLNSNQVISFSFSMDSTNN-..ENVIFDKLVFVPSD................................
A0A9P9J9J5_9HYPO/23-140                ................rikanfeissw------------.---HSKSSDETDVSGNVI.SVNPKLPI...LAAIAYT.--.-NRNNEY.EVRVYY..V..A..K....K.N.FQ..L.AYQI..A.DNSGL......TANVVKTCGGTLQ......LKL-..--Y..YQCAANKL..........HFSY------------------..--------------nasdnkkenwsirsdvtn..............
A0A926X0F8_9CYAN/5-134                 ..................rleaekmtl------------.-TNAVVETGSFASGGALA.MLSGPTGG...--YSTVF.--.SGLSGSY.QVVIGY..Y..D..E....S.D.GV..A.QLTV..N.VNGTQl....dSWALNQSLGN---......TRAG..SNN..FVRRTIAS..........NLAIAQGSSIDIL-GIQQAG--..ENARVDYIEFIPI-a...............................
A3RLZ7_BACTU/499-636                   ...........................ITQIPMVKASEL.PQGTTVVRGPGFTGGDIL.-RRTNTGG...FGPIRVT.VN.GPLTQRY.RIGFRY..A..S..T....V.D.FD..F.FVSR..G.GTTVN......NFRFLRTMNSGDE......LK--..YGN..FVRRAFTT..........PFTFTQIQ-DIIRTSIQGLSGN..GEVYIDKIEIIPVT................................
A0A1S8TW68_9CLOT/491-622               ...........................ITQIPSVKSYST.---SKVVKGPGHTGGDVV.LLNSGGSL...--SLKFH.-S.TEDRKRY.RIRLRY..A..S..D....Q.D.IL..I.GIGR..T.MMILS......YFDIKKTGIDISN......HPEK..YEL..YKYVDTSY..........---ITGDMDTELVLHYPKQIP-..GNVFIDKIEFIPFD................................
#=GC seq_cons                          .............................................h.tt.hhsuGshl.phtssssh....sphphs....sstsspY.pltlcY..t..s..s....s.s.sp..l.plpl..s.ssshs......shshspstss.tt......ht.....ss..aphhshss..........shslptsp..slphth.s.ps...pph.lDpIEhlPh.................................
//