#=GF ID Epsilon_antitox
#=GF AC PF08998.18
#=GF DE Bacterial epsilon antitoxin
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF SE pdb_1gvn
#=GF GA 28.10 28.10;
#=GF TC 28.10 32.00;
#=GF NC 27.00 27.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP Domain
#=GF WK Epsilon_antitoxin
#=GF RN [1]
#=GF RM 12571357
#=GF RT Crystal structure of the plasmid maintenance system
#=GF RT epsilon/zeta: functional mechanism of toxin zeta and
#=GF RT inactivation by epsilon 2 zeta 2 complex formation.
#=GF RA Meinhart A, Alonso JC, Strater N, Saenger W;
#=GF RL Proc Natl Acad Sci U S A 2003;100:1661-1666.
#=GF RC Paper describing PDB structure 2p5t
#=GF RN [2]
#=GF RM 17488720
#=GF RT Molecular and structural characterization of the PezAT
#=GF RT chromosomal toxin-antitoxin system of the human pathogen
#=GF RT Streptococcus pneumoniae.
#=GF RA Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart
#=GF RA A;
#=GF RL J Biol Chem. 2007;282:19606-19618.
#=GF DR INTERPRO; IPR015090;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The epsilon antitoxin, produced by various prokaryotes, forms
#=GF CC part of a postsegregational killing system which is involved in
#=GF CC the initiation of programmed cell death of plasmid-free cells.
#=GF CC The protein is folded into a three-helix bundle that directly
#=GF CC interacts with the zeta toxin, inactivating it [1].
#=GF SQ 63
#=GS A0A7G3MLN2_9CAUD/71-152 AC A0A7G3MLN2.1
#=GS A0A810Q7E1_9FIRM/1-54 AC A0A810Q7E1.1
#=GS PEZA_STRPN/71-152 AC Q97QZ2.1
#=GS A0A377GZF3_9FUSO/2-80 AC A0A377GZF3.1
#=GS A0A380JDQ9_STRDO/71-152 AC A0A380JDQ9.1
#=GS F7UWW4_EEGSY/3-83 AC F7UWW4.1
#=GS A0A7G3ML59_9CAUD/71-152 AC A0A7G3ML59.1
#=GS A0A1C0BV01_9FIRM/3-83 AC A0A1C0BV01.1
#=GS A0A0H2ZMN0_STRP2/71-152 AC A0A0H2ZMN0.1
#=GS A0A923MG70_9FIRM/2-82 AC A0A923MG70.1
#=GS I8WW62_9BACE/3-83 AC I8WW62.1
#=GS C8WL78_EGGLE/101-183 AC C8WL78.1
#=GS A0A139NFU1_9STRE/71-152 AC A0A139NFU1.1
#=GS A0A430AN42_9ENTE/5-88 AC A0A430AN42.1
#=GS A0A4Y9J7Y8_9LACT/71-152 AC A0A4Y9J7Y8.1
#=GS A0A7X1Z7X4_9LACT/74-153 AC A0A7X1Z7X4.1
#=GS D6E8Z0_9ACTN/101-184 AC D6E8Z0.1
#=GS A0A7X6N052_9STRE/71-152 AC A0A7X6N052.1
#=GS Q8CYT3_STRR6/90-171 AC Q8CYT3.1
#=GS F9HGN1_9STRE/71-152 AC F9HGN1.1
#=GS A0A1Y4WR18_9FIRM/3-83 AC A0A1Y4WR18.1
#=GS A0AAF0CWZ9_9ENTE/5-88 AC A0AAF0CWZ9.1
#=GS A0A430APP3_9ENTE/21-101 AC A0A430APP3.1
#=GS A0A6N8U3W2_9FIRM/3-83 AC A0A6N8U3W2.1
#=GS A0A3L9DVT6_9STRE/71-152 AC A0A3L9DVT6.1
#=GS F5X6Y7_STRPX/71-152 AC F5X6Y7.1
#=GS A0A1L8SS81_9ENTE/3-83 AC A0A1L8SS81.1
#=GS A0AA43L2P5_9ENTE/4-84 AC A0AA43L2P5.1
#=GS A0A377GNR0_9FUSO/3-84 AC A0A377GNR0.1
#=GS A0A143X1N3_9ACTN/3-83 AC A0A143X1N3.1
#=GS A0A430AM49_9ENTE/3-83 AC A0A430AM49.1
#=GS C2KZ75_9FIRM/71-152 AC C2KZ75.1
#=GS A0AAE3ANF6_9FIRM/1-54 AC A0AAE3ANF6.1
#=GS A0A4D7AX49_9FIRM/2-82 AC A0A4D7AX49.1
#=GS A0A6I8M9K1_9FUSO/2-83 AC A0A6I8M9K1.1
#=GS A0A0H3MV38_STRS4/3-83 AC A0A0H3MV38.1
#=GS J3EPN3_9LACO/3-83 AC J3EPN3.1
#=GS C9LPV0_9FIRM/13-95 AC C9LPV0.1
#=GS R9L2G6_9ACTN/101-184 AC R9L2G6.1
#=GS A0A429ZN65_9ENTE/5-88 AC A0A429ZN65.1
#=GS A0A3N0I2F2_9FIRM/3-83 AC A0A3N0I2F2.1
#=GS S0NSW0_9ENTE/71-152 AC S0NSW0.1
#=GS A0A429ZSI2_9ENTE/3-83 AC A0A429ZSI2.1
#=GS A0A0H3MVR4_STRS4/71-152 AC A0A0H3MVR4.1
#=GS A0A2X3XXA9_9STRE/71-152 AC A0A2X3XXA9.1
#=GS E6LIR7_ENTI1/3-83 AC E6LIR7.1
#=GS R2RYY6_9ENTE/1-81 AC R2RYY6.1
#=GS A0A2K2UDR6_9ACTN/3-83 AC A0A2K2UDR6.1
#=GS A0A6A0BG46_9LACT/3-83 AC A0A6A0BG46.1
#=GS K5Y7B9_9BACT/3-83 AC K5Y7B9.1
#=GS S0KL36_9ENTE/5-84 AC S0KL36.1
#=GS A0A3N0BLH8_9ACTN/101-183 AC A0A3N0BLH8.1
#=GS A0A923RXA9_9FIRM/3-83 AC A0A923RXA9.1
#=GS R8W158_9FIRM/3-83 AC R8W158.1
#=GS A0A430AHQ4_9ENTE/5-85 AC A0A430AHQ4.1
#=GS A0A4Y9J620_9LACT/71-152 AC A0A4Y9J620.1
#=GS S0KLW1_9ENTE/71-152 AC S0KLW1.1
#=GS A0A7G3MJ42_9CAUD/3-34 AC A0A7G3MJ42.1
#=GS A0A380KAK9_9STRE/71-152 AC A0A380KAK9.1
#=GS A0A1X9I6E5_9CAUD/3-34 AC A0A1X9I6E5.1
#=GS V8B9N1_STRPA/71-152 AC V8B9N1.1
#=GS G5KG27_9STRE/71-152 AC G5KG27.1
#=GS A0A1L8RCE9_9ENTE/3-66 AC A0A1L8RCE9.1
A0A7G3MLN2_9CAUD/71-152 ...EDYQLTLRIEVIKERGAAILSQLYRYQD..SQDIAFDD...ESNPWILMSDDL...AELINTKIYLV..DTFDEIERYNGYLDGIERMLEMV.....
A0A810Q7E1_9FIRM/1-54 ..m----------------------------..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
PEZA_STRPN/71-152 ...EDYELTLKIEIVKERGANLLSRLYRYQD..SQGISIDD...ESNPWILMSDDL...SDLIHTNIYLV..ETFDEIERYSGYLDGIERMLE--is...
A0A377GZF3_9FUSO/2-80 ..s-LYEINLQREILREKSAEILADYRRHFK..KYG-----...KNNKILENLYNS...VEYIHTNIFDSeyNSIEKLSTANGKLDLAWDIIKN-l....
A0A380JDQ9_STRDO/71-152 ...EDYQLTLKIEIIKERGAGILSQLYRYQD..SQGIDFDD...VSNPWILMSDDL...SDLINSKIYLV..ASFDELDRYNGYLDGIERMLE--la...
F7UWW4_EEGSY/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
A0A7G3ML59_9CAUD/71-152 ...EDYHLTLKVEVIKERGAAILSKLYRYQD..SQDIVFDD...ESNPWILMSDDL...AELINTKIYLV..ATFDEIERYNGYLDGIERMLDMV.....
A0A1C0BV01_9FIRM/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
A0A0H2ZMN0_STRP2/71-152 ...EDYELTLKIEIVKERGANLLSRLYRYQD..SQGISIDD...ESNPWILMSDDL...SDLIHTNIYLV..ETFDEIERYSGYLDGIERMLE--is...
A0A923MG70_9FIRM/2-82 ...SNYEFSLRQEVLLEKGADILGSLFHFAR..NNHISPSD...KKDP-VNVVYGL...VWNAKSSILGA..DTEAELDRIETQFDFARKFYAGI.....
I8WW62_9BACE/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
C8WL78_EGGLE/101-183 ...EMYEITLQQEVLNEQAAQLMGDTINLLL..AAREQEDA...---IAEAVYEDVlkqISHIKPRIISEghLNTVRLSEIRGQIECLKNMVD--s....
A0A139NFU1_9STRE/71-152 ...EDYELTLKIEIVKERGANLLARLYHYQD..SQGISIDD...ESNPWILMSDDL...SDLIHTNIYLV..ETFDEIERYSGYLDGIERMLE--is...
A0A430AN42_9ENTE/5-88 .qm--ESKIYQIELLNEFSMSVYNRLLRHVH..KNKIDLTHqahQENFIVLLFHQL...EETLSLNLFK-..KELKELEEIKHYWITMNSLTKEI.....
A0A4Y9J7Y8_9LACT/71-152 ...EDYQLTLKIEVIKERGVAILSRLYQYQD..SHNIAFDD...ISNPWILMSDDL...ADLMNTKIYLV..DTFDELERYNGYLDAIERMLE--la...
A0A7X1Z7X4_9LACT/74-153 ...EQYQLTLNQEVMKEYAATVLAELSKYLI..KHDIEADN...--DPLQVLFMEL...SAVKNKQIFNT..KTNQELDKIQGYLDGIKRFVST-l....
D6E8Z0_9ACTN/101-184 ...EMYMLTLEQEILNEKAAEILAEVSRLYL..EAE-SKGD...KE--GMLVYDDVmslIAERKRQIIYKenDSFTKLAEIRGSIEGLERLAKRV.....
A0A7X6N052_9STRE/71-152 ...EDYQLTLKIEIIKERGAAILSELYRYQD..SQGIAFDN...ETSPWILMSDDL...SDLINTKIYLV..DTFDEVERYNGYLDGIERMLE--la...
Q8CYT3_STRR6/90-171 ...EDYELTLKIEIVKERGANLLSRLYRYQD..SQGISIDD...ESNPWILMSDDL...SDLIHTNIYLV..ETFDEIERYSGYLDGIERMLE--is...
F9HGN1_9STRE/71-152 ...EDYQLTLKIEVIKERGANILAQLYRFQD..EQGIAFDD...TSNPWVLMSDDL...SDLLNTKIYLV..GTFDEVERYNGYLDGIERMLEQ-a....
A0A1Y4WR18_9FIRM/3-83 ..s-SYEFSLRQEILLEKGADILGSISRFGR..RNNIPLSD...RTNP-VNVMYAL...VWHAKHDILDA..RTESELDQIDTQFDLARRFSAGI.....
A0AAF0CWZ9_9ENTE/5-88 .qm--ESKIYQIELLNEFSMSVYNRLLRHVH..KNKIDLTHqahQENFIVLLFHQL...EETLSLNLFK-..KELKELEEIKHYWITMNSLTKEI.....
A0A430APP3_9ENTE/21-101 ..v-NYEHTLEVEVINEFAANVRNKLINYLG..QTTIDLND...AKHPMVELLNAL...SEMKNRNLFE-..KSKEELAEVLFYWQQMNRYIETI.....
A0A6N8U3W2_9FIRM/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
A0A3L9DVT6_9STRE/71-152 ...EDYQLTLKIEVIKERGAAILSQLYRYQD..SQGIAFDD...ETNPWILMSDDL...SDLINTKIYLV..NTFDEVERYNGYLDGIERMLE--la...
F5X6Y7_STRPX/71-152 ...EDYQLTLKIEVIKERGAAILSQLYRYQD..SQDIAFDD...ETNPWILMSDDL...AELINTKIYLV..DTFDEIERYNGYLDGIERMLEMV.....
A0A1L8SS81_9ENTE/3-83 ..v-TYEKIFEIEIINELSASVYNRVLNYVL..NHELDTKN...TRLLEVNLLNQL...EVAQEVDLFQ-..QPFEELQAIHEYWRSMNQYSKQI.....
A0AA43L2P5_9ENTE/4-84 ..i-DYNHTLRVEVINEYAANVQNKLTNYLR..QTEVSLED...VNNPMMILFDEL...AEIKSVNLFE-..KTDVELNEYLFYWKSQDKFIQKI.....
A0A377GNR0_9FUSO/3-84 ..s-LYEINLRREILREKSAEILADYDKYLD..ENNISYES...-LNP-VRVLEKI...ISEIYRNIFKPeyETIEKLNEANIKLDLALEVLKK-l....
A0A143X1N3_9ACTN/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
A0A430AM49_9ENTE/3-83 ..l-DYRKTFEIEIINEFQSAIHSKMLNYVL..NNELDKSD...STNLQTNLLNQL...SNMNQINLFK-..LSLEELEAYHEYLRSIKKYADSI.....
C2KZ75_9FIRM/71-152 ...EEYQLSSKIDLFKERAASILARLYHFQD..KHAIAFDD...EQNPWVLLGDDL...SMILQDKIYTI..QSVEELERYQGYLDGIERMLD--la...
A0AAE3ANF6_9FIRM/1-54 ..m----------------------------..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
A0A4D7AX49_9FIRM/2-82 ...SNYEFSLRQEVLLEKGADILGSLFHFAR..NNHISPSD...KKDP-VNVVYGL...VWNAKSSILGA..DTEAELDQIETQFDFARKFYAGI.....
A0A6I8M9K1_9FUSO/2-83 ..l-DYKITLEKEVLREKSSGILADFYRFFL..ENEISETN...--KKILLILDDE...VTKIYRNIFGSeyDSFEKLHEANGKLDLASSVLKRI.....
A0A0H3MV38_STRS4/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
J3EPN3_9LACO/3-83 ..l-DYRKTFEIEIINEFQSAIHSKMLNYVL..NNELDKSD...STNLQTNLLNQL...SDMNQINLFK-..LSLEELEAYHEYLRSIKKYADSI.....
C9LPV0_9FIRM/13-95 ..t-PYEVIEKKEVLHECFAQLLADSSHLRQ..RLAIDRDD...ATHP-LNIFRER...ILRIFHDIFTVqyQTEADMQKLLEQLQYARSSLQQL.....
R9L2G6_9ACTN/101-184 ..d-IYELTLQQEVLNEKAAEILGDIINGLI..EAE-ERND...EG--LKMVYEDLfaqLSLLKPTIASTetANWDTLQSIDGELNCMRSLCNRV.....
A0A429ZN65_9ENTE/5-88 qve---SKIYQIELLNEFSMSVYNRLLRHVH..KNKIDLTHqahQENFIVLLFHQL...EETLSLNLFK-..KELKELEEIKHYWITMNSLTKEI.....
A0A3N0I2F2_9FIRM/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
S0NSW0_9ENTE/71-152 ...EDYQLTLKVEVIKERGAAILSQLYRYQD..SQDIAFDD...EANPWILMSDDL...AELINTKIYLV..DTFDEIERYNGYLDGIERMLDMV.....
A0A429ZSI2_9ENTE/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
A0A0H3MVR4_STRS4/71-152 ...EDYHLTLKVEVIKERGAAILSQLYRYQD..SQDIAFDD...ESNPWILMSDDL...AELINTKIYLV..DTFDEIERYNGYLDGIERMLDMV.....
A0A2X3XXA9_9STRE/71-152 ...EDYQLTLKVEVIKERGAAILSQLYRYQD..SQDIAFDD...EANPWILMSDDL...AELINTKIYLV..DTFDEIERYNGYLDGIERMLDMV.....
E6LIR7_ENTI1/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELDTKN...TRLLEVNLLNQL...EVAQEVDLFQ-..QPFEELQAIHEYWRSMNQYSKQI.....
R2RYY6_9ENTE/1-81 ...MDYEKTFKIESLNEFSRNVYNRVLRYVV..NHQIDRQN...KNDLYAELLDQL...KGMLQMNLFE-..MSMSDLAKVESYWNAMDVYTKSI.....
A0A2K2UDR6_9ACTN/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
A0A6A0BG46_9LACT/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NYELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNLYSKQV.....
K5Y7B9_9BACT/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
S0KL36_9ENTE/5-84 ..i-DYELTAKIEIINEFSYGIYNRLLNYIL..NNGIDKNG...-SNLYSAILSTL...RRMLSIDLFS-..YNRGELDKMLIYWKNMNQYINEI.....
A0A3N0BLH8_9ACTN/101-183 ...ELYEITLQQEVLNEQAAQIMGKVARLRGaaQRRGDVVA...-----EAVFEDVlkqLALIRPSITYRenLNDVKLSEIRGQIECLRNLA---ea...
A0A923RXA9_9FIRM/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
R8W158_9FIRM/3-83 ..v-TYEKTFEIEIINELSASVYNRVLNYVL..NHELNKND...SQLLEVNLLNQL...KLAKRVNLFD-..YSLEELQAVHEYWRSMNRYSKQV.....
A0A430AHQ4_9ENTE/5-85 qve---SKIYQIELLNEFSMSVYNRLLRHVH..KNKIDLTH...QENFIALLFRQL...EEMLSLNLFK-..KELEELEEIKHYWVNMNSLTKEI.....
A0A4Y9J620_9LACT/71-152 ...EDYQLTLKIEVIKERGAAILSQLYRYQD..SQGIAFDD...ETNPWILMSDDL...AELINTKIYLV..DTFDEIERYNGYLDGIERMLDMV.....
S0KLW1_9ENTE/71-152 ...EDYQLTLTIEVLKERGAAILSRLYHYQD..TQGIAFDD...VSNPWILMSDDL...ANLINTKLYLV..DSFGELERYNGYLDGIERMLMMV.....
A0A7G3MJ42_9CAUD/3-34 ..v-TYEKTFEIEIINELSASVYNRVLNYC-..--------...------------...-----------..-----------------------llmii
A0A380KAK9_9STRE/71-152 ...EDYQLTLKMEVLKERGAAILAELYRYQD..KHGIAFDD...ETNPWILMSDDL...ADIITTQIYLA..DTFEELERYDGYLDGIERMLV--mt...
A0A1X9I6E5_9CAUD/3-34 ..v-TYEKTFEIEIINELSASVYNRVLNYC-..--------...------------...-----------..-----------------------llmii
V8B9N1_STRPA/71-152 ...EDYQLTLKIEVIKERGANILAQLYRFQD..ELGISYDD...TSNPWVLMSDDL...SDLLNTKIYLV..GTFDEVERYNGYLDGIERMLEQ-a....
G5KG27_9STRE/71-152 ...EDYQLTLKIEVIKERGAAILSQLYRYQD..SQGIAFDD...ETNPWILMSDDL...SDLINTKIYLV..NTFDEVERYNGYLDGIERMLE--la...
A0A1L8RCE9_9ENTE/3-66 ..i-SYEKTFEIEIINELSASVYNRVLNYVL..NHELDTDN...TQLLEVNLLNQL...KLAKRVNLFE-..YSLDEL-----------------.....
#=GC seq_cons ....sYchThcIEllpEhuAulhsclhpYh...spclshsD...ppp..l.lhspL...pthhpsslat...toh-ELpphptYhcuhpRhhctl.....
//
