GenomeNet

Database: Pfam
Entry: EspG
LinkDB: EspG
Original site: EspG 
#=GF ID   EspG
#=GF AC   PF06872.14
#=GF DE   EspG protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_13549 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   551.00 550.80;
#=GF NC   22.10 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11349072
#=GF RT   EspG, a novel type III system-secreted protein from
#=GF RT   enteropathogenic Escherichia coli with similarities to VirA of
#=GF RT   Shigella flexneri. 
#=GF RA   Elliott SJ, Krejany EO, Mellies JL, Robins-Browne RM, Sasakawa
#=GF RA   C, Kaper JB; 
#=GF RL   Infect Immun 2001;69:4027-4033.
#=GF DR   INTERPRO; IPR009669;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several EspG like proteins from
#=GF CC   Citrobacter rodentium and Escherichia coli. EspG is secreted by
#=GF CC   the type III secretory system and is translocated into host
#=GF CC   epithelial cells. EspG is homologous with Shigella flexneri
#=GF CC   protein VirA and can rescue invasion in a Shigella virA mutant,
#=GF CC   indicating that these proteins are functionally equivalent in
#=GF CC   Shigella.  EspG plays an accessory but as yet undefined role in
#=GF CC   EPEC virulence that may involve intestinal colonisation [1].
#=GF SQ   4
#=GS Q7DB50_ECO57/1-380   AC Q7DB50.2
#=GS Q7DB50_ECO57/1-380   DR PDB; 4FMC A; 47-397;
#=GS Q7DB50_ECO57/1-380   DR PDB; 3PCS D; 42-395;
#=GS Q7DB50_ECO57/1-380   DR PDB; 3PCS A; 42-397;
#=GS Q7DB50_ECO57/1-380   DR PDB; 3PCS C; 42-395;
#=GS Q7DB50_ECO57/1-380   DR PDB; 4FME D; 47-397;
#=GS Q7DB50_ECO57/1-380   DR PDB; 4FMD A; 47-397;
#=GS Q7DB50_ECO57/1-380   DR PDB; 3PCS B; 43-397;
#=GS Q7DB50_ECO57/1-380   DR PDB; 4FMD E; 47-396;
#=GS Q7DB50_ECO57/1-380   DR PDB; 4FMC E; 47-396;
#=GS Q7DB50_ECO57/1-380   DR PDB; 3PCR A; 47-395;
#=GS Q7DB50_ECO57/1-380   DR PDB; 4FMD C; 47-397;
#=GS Q7DB50_ECO57/1-380   DR PDB; 4FMC C; 48-397;
#=GS Q7DB50_ECO57/1-380   DR PDB; 4FME A; 47-397;
#=GS VIRA_SHIFL/3-399     AC Q7BU69.1
#=GS VIRA_SHIFL/3-399     DR PDB; 3EB8 A; 53-399;
#=GS VIRA_SHIFL/3-399     DR PDB; 4FMB A; 45-399;
#=GS VIRA_SHIFL/3-399     DR PDB; 3EB8 B; 52-399;
#=GS VIRA_SHIFL/3-399     DR PDB; 4FMB E; 45-399;
#=GS VIRA_SHIFL/3-399     DR PDB; 4FMB C; 45-399;
#=GS VIRA_SHIFL/3-399     DR PDB; 3EE1 A; 58-399;
#=GS VIRA_SHIFL/3-399     DR PDB; 3EE1 B; 58-399;
#=GS D2TKD5_CITRI/15-397  AC D2TKD5.1
#=GS VIRA_SHIDS/3-399     AC Q326N4.1
Q7DB50_ECO57/1-380              ---MINGLNNDSASLVLDAAMKVNSGFKKSWDEMSCAEKLFKVLSFGLWNPTYSRSERQSFQELLTVLEPVYPLPNELGRVSARFSDGSSLRISVTNSELVEAEIRTANNEKI.TVLLESNEQNRLLQSL.PIDRHMPYIQVHRALSEMDLTDTTSMRNLLGFTSKLSTTLIPHNAQTDPLSGPTPFSSIFMDTCRGL.....GNAKLSLNGVDIPANAQKLLRDALGLKDTHSSPTRNVIDHGISRHDAEQIARESSGSDK.....QKAEVVEFLCHPEAATAICSAFYQSFNVPALTLTHERISKASEYNAERSLDTP..............NACI...NISISQSSDGNIYVTSHTGVLIMAPEDRPNEMGMLTNRTSYEVPQGVKCIIDEMVSALQP..RYAASETYLQN
#=GR Q7DB50_ECO57/1-380   SS    ---XXXXXXXXXXXXXXXXXXXXXXXXXXSTT---HHHHHHHHHHHHTT-TTS-SHHHHHHHHHHTTEEEE---TTEEEEEEEE-TTS-EEEEEEETTTEEEEEEE-TTS-EE.EEEE-SSTTTTTGGGS.S-EE--SB-EEEEESSS--TSSHHHHHHHHHHHTTS-EEEE-B-TTT-TTSSSSTTTTHHHHHHHHT.....TTSEEEETTEEE-HHHHHHHHHHTT-SSTT----HHHHHH-S-HHHHHHHHHTSBS-HH.....HHHHHHHHHTSHHHHHHHHHHT-GGGGHHHHHHHHHHHHHHHHHHHTTT----..............SEEE...EEEEEE-TTS-EEEEEEEEEEEE--TTSTT-EEEEEEEEEEEE-TT--S-HHHHHHH---..EEEEEEEEE--
VIRA_SHIFL/3-399                TSNITNHERNDSSWMS-----TVKSTTEVSWNKLSFCDILLKIITFGIYSPHETLAEKHSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKG---ICSVFYLDGDKIqSTQLSSKEYNNLLSSLpPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFH--VKDTDFNSVWHDIYRDIrasdsNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQM---LSYNQVNKIINSNFPQQDlcfqtEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPeqrvinncghiikiNAVVpknDTAISASGGRAYEVSSS----ILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPesRQVSFAIISPD
#=GR VIRA_SHIFL/3-399     SS    XXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXHHHHHHHHSHHHHHHHTEEE--STTS-TTEEEEEEETTEEEEEEEETT---EEEEEEEETTEEEEEEEEHHHHHHHHHHS-SSEE--SS--EEEEEEE--SS-SS--HHHHHHHHHS-EEE---SSB------TTTTTTHHHHHHHHHHTGGGST-EEEETTEEE-HHHHHHHHHHTT-SSSS-TT-B--------HHHHHHHHHHHS-TTSHHHHHHHHHHHHHTT-HHHHHHHHHTT-TTTT--BHHHHHHHHHHHHHHHHHHHHH-SS----SEEEEEEEEEEE--------------EEEEEEE----EEEEEEESSSEEEEEEEEEEEE-SS--SSHHHHHHHS-GGG-EEEEEEEEEE
D2TKD5_CITRI/15-397             RAFMLNGLNNNSASLVLDATIKINSDYKKPWNEMTCAEKLLKILTLGLWNPKYSQDERQQFQGLLTVLEPVSPAHNELGRVYAKFSDGSSLRISVTNSELIEAEIHTPNNEKF.LVLLEANEQNRLLQSL.PINRHMPYIQVHHTLPQEELTDLLSMHKLLSFTSKLSATLIPHNNQTDPLSGLTPFSTVFMDTSRGL.....GNSKLSLNGVDIPADAQKLLRNTLGLKDTNSSPDLNVIRNGIPRHYAEQIVKESSSTNE.....QKAAVVDFLCQPEAPTAICSAFYQSFNVPALMLTHVRISQASAYNAQRSLDMP..............NACI...NISITQSSEGSIHVTSHTGVLIMAPEDRPNQLGMLTNRTSYEVPPGVKCEPNEMARMLKA..KYASSETYLNN
VIRA_SHIDS/3-399                TSNITNYERNDSSWMS-----TVKSTTEVSWNKLSFCDVLLKIITFGIYSPHETLAEKYSEKKLMDSFSPSLSQDKMDGEFAHANIDGISIRLCLNKG---ICSVFYLDGDKIqSTQLSSKEYNNLLSSLpPKQFNLGKVHTITAPVSGNFKTHKPAPEVIETAINCCTSIIPNDDYFS--VKDTDFNSVWHDIYRDIrasdsNSTKIYFNNIEIPLKLIADLINELGINEFIDSKKELQM---LSYNQVNKIINSNFPQQDlcfqtEKLLFTSLFQDPAFISALTSAFWQSLHITSSSVEHIYAQIMSENIENRLNFMPeqrvinncghiikiNAVVpknDTAISASGGRAYEVSSS----ILPSHITCNGVGINKIETSYLVHAGTLPSSEGLRNAIPPesRQVSFAIISPD
#=GC SS_cons                    XXXXXXXXXXXXXXXX-----XXXXXXXXSTTXXXHHHHHHHHHHHHTTXCCCHCHHHCHHHHHHCTEEEE-STTTECCEEEEEECTTEEEEEEEETTTEEEEEEEECCTTEEEEEEEECCCCCCCHHHS-SSEE--SC-EEEEECCC--TSSCCHHHHHHHHHCCS-EEEE-BSTCT-TTSSTTTTTTHHHHHHHHCHTGGGTTSEEEETTEEE-HHHHHHHHHHTT-SSTT-TT-CHHHHH-S-HHHHHHHHHCCCSTCCHHHHHHHHHHHHHCTSHHHHHHHHHCT-CCCCHHCHHHHHHHHHHHHHHHHCCCHH-SS----SEEEEEEEECEEE---EEEEEE-TTSEEEEEEEEEEEEEEECCCTTSEEEEEEEEEEEE-TT--SSHHHHHHHS-GGGEEEEEEEEEEE
#=GC seq_cons                   pu.hhNt.pNDSu.hs.....pVpSshchSWNchShs-hLLKIlTFGlasP+.ohuE+pS.pcLhsshpPshstcp..Gchutt..DG.SlRlslspu....splahhss-KI.os.LpSpE.NpLLpSL.PhphphshlpshpA.sptshpsppsh.cllphs.phsTolIPpss.hc..stsTsFsSVahDhhRsl.....ssoKl.hNsl-IPhch.t.LhNpLGlp-hhsS.cc..h...lShppsppIlpps.spp-.....pKhhhsshhpcPthhoAlsSAFaQShplsu.olpHlhhphhSE..tpR...MP..............NAsl...shuIStSustuhcVoSp....Ihssc.psNtlGh.p.cTSY.V.sGshsps-thtsAl.P..R.sS.thh.ss
//
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