GenomeNet

Database: Pfam
Entry: FIN1
LinkDB: FIN1
Original site: FIN1 
#=GF ID   FIN1
#=GF AC   PF17300.5
#=GF DE   Filaments in between nuclei protein-1
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD127795
#=GF GA   25.00 25.00;
#=GF TC   28.70 30.80;
#=GF NC   21.80 23.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11929974
#=GF RT   The Saccharomyces cerevisiae Fin1 protein forms cell
#=GF RT   cycle-specific filaments between spindle pole bodies.
#=GF RA   van Hemert MJ, Lamers GE, Klein DC, Oosterkamp TH, Steensma HY,
#=GF RA   van Heusden GP;
#=GF RL   Proc Natl Acad Sci U S A. 2002;99:5390-5393.
#=GF RN   [2]
#=GF RM   26832405
#=GF RT   Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1
#=GF RT   from Kinetochores in Anaphase.
#=GF RA   Bokros M, Gravenmier C, Jin F, Richmond D, Wang Y;
#=GF RL   Cell Rep. 2016;14:1074-1085.
#=GF DR   INTERPRO; IPR035260;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Fin1 is a kinetochore protein, predicted to contain two putative
#=GF CC   coiled-coil regions at its C terminus. It is present in a
#=GF CC   filamentous structure associated with the spindle and spindle
#=GF CC   pole in dividing cells during anaphase [1]. Fin1 is a substrate
#=GF CC   of S-phase cyclin-dependent kinase (CDK). It binds to PP1
#=GF CC   creating the Fin1- PPI complex which is recruited onto
#=GF CC   kinetochores promoting spindle assembly checkpoint (SAC)
#=GF CC   dis-assembly during anaphase [2]. This is an important step in
#=GF CC   cell division since the kinetochore is the docking site for the
#=GF CC   spindle assembly checkpoint that monitors the defects in
#=GF CC   chromosome attachment and blocks anaphase onset [1]. Fin1 has
#=GF CC   two RXXS/T sequences: S377 (RVTS), S526 (RKVS) that can be
#=GF CC   phosphorylated. Upon phosphorylation, interactions with other
#=GF CC   proteins such as Bmh1 and Bmh2 is promoted. However,
#=GF CC   de-phosphorylation during anaphase promotes the kinetochore
#=GF CC   recruitment of Fin1-PP1 [2].
#=GF SQ   27
#=GS H2AR55_KAZAF/2-108       AC H2AR55.1
#=GS A0A376B2W4_9ASCO/36-317  AC A0A376B2W4.1
#=GS Q750A6_ASHGO/6-227       AC Q750A6.1
#=GS A0A1G4MK74_LACFM/15-258  AC A0A1G4MK74.1
#=GS FIN1_YEAST/15-283        AC Q03898.1
#=GS A0A1G4KIZ7_9SACH/26-259  AC A0A1G4KIZ7.1
#=GS C5DVF6_ZYGRC/15-254      AC C5DVF6.1
#=GS A0A0C7MTG6_9SACH/4-252   AC A0A0C7MTG6.1
#=GS Q6FXC3_CANGA/6-256       AC Q6FXC3.1
#=GS G8JTI2_ERECY/17-247      AC G8JTI2.1
#=GS A0A1G4JIE6_9SACH/4-257   AC A0A1G4JIE6.1
#=GS A0A1X7R617_9SACH/79-184  AC A0A1X7R617.1
#=GS H2AR55_KAZAF/79-203      AC H2AR55.1
#=GS J8PJT9_SACAR/15-285      AC J8PJT9.1
#=GS C5DMZ2_LACTC/14-262      AC C5DMZ2.1
#=GS J4TT80_SACK1/15-282      AC J4TT80.1
#=GS G0VBX4_NAUCC/1-227       AC G0VBX4.1
#=GS A0A7H9B839_ZYGMR/20-256  AC A0A7H9B839.1
#=GS A0A1S7HK91_9SACH/15-255  AC A0A1S7HK91.1
#=GS A0A1S7HGQ8_9SACH/15-260  AC A0A1S7HGQ8.1
#=GS G0WGS5_NAUDC/22-283      AC G0WGS5.1
#=GS A7TJ22_VANPO/10-269      AC A7TJ22.1
#=GS A0A1X7R617_9SACH/1-78    AC A0A1X7R617.1
#=GS Q6CJB4_KLULA/24-230      AC Q6CJB4.1
#=GS G8ZX91_TORDC/12-250      AC G8ZX91.1
#=GS A0A7H9I0N7_9SACH/11-251  AC A0A7H9I0N7.1
#=GS G8BR78_TETPH/10-257      AC G8BR78.1
H2AR55_KAZAF/2-108                  ..............vhtem--------NE.....TSSNVFKR..LQISPSKNS---...RIKKPA.MRLS....PKKITT-........SAVPQYTP..MKISS.PECL.K----......RY.TRSL...DRTGTinvaPKTVHLSP...VRt.......haSLRS-SHGVTIVSPIRAN...LQ--.------------------.-------------...........................---------------------..........-----------------.....------.....------------------........----------------------------------dq....................................
A0A376B2W4_9ASCO/36-317             ..............nnltn---STTENNN.....NSSNVFKR..LS--PVFNKPAI...RISPDKnKRIA....IKRTNTSsiyesvalTTTPLLTPkkKRLVS.PTKY.NNLISrgngikSR.IYSV...GNSTT....NKIDKPKN...VHk........pVSKEILNYEFPTSPLK--...LSPT.RTIGGDGSLNRIRSRFSQlKKNSPEKKDIMETey.......................dkLDTTPFHSKRNLLTKLLEEEV..........QNTPIKSALKPEVFAKD....eKSDHKM....dDPISVTKKKVTFNLPDTSmss..ndpSLIEQE-QEI------------------------hhnslldtgdkkdeilsillqvlkrqdaiehkldiiin
Q750A6_ASHGO/6-227                  ...................NDISNREAAT.....RGSDVFKR..LAGSPMRRDGAA...-MDKPA.MRLS....PG-----........KHAYQTSP..KRLLA.PEHL.R----......SL.TQSV...DRHFF....-NTARAT-...--..........GRPGSRDAAFTASPTKGDg.gFSNM.TVAGGDGSLSRIRNRF--.---SPVKERKPILa.........................sEQEDGAATRQNLLAKLQREED..........--VTQVTRRNTRQNSEAs...rYKVGKS.....-QIVTRSRNVKFELPED-........RMIAIELQNLKQLIHTLIERQDQLEDRLTRLEEQ......................................
A0A1G4MK74_LACFM/15-258             ..................s-DIGNKVRCS.....PSKNVYKR..LGTSPMKKYSND...-LSKPP.MRIS....PAKRQPPh.....egSNFFQTTP..KRLRS.PQSL.KAYPR......EG.TSSV...DRINF....-KGSESV-...--..........-NSTGTDFVFHTSPVRPK...FSNI.INVGGDGSLSRIRTRFSN.GVKSPQKEKEIHS...........................--AYPDKVQKNLFVQLQQQESlh.....nslSDFNDTTRINTTINSMKirpqdDKKTIK....kPKSLAKKKTVKFELNEE-........KNLKSELSEIRALLMNLTERQDQLEQRLFS----rees..................................
FIN1_YEAST/15-283                   ..................n-TIGRNNIPS.....DKDNVFVR..LSMSPLRTTSQK...EFLKPP.MRIS....PNKTDGM........KHSIQVTP..RRIMS.PECL.KGYVS......KE.TQSL...DRPQF....KNSNKNVK...IQ..........NSDHITNIIFPTSPTKLT...FSNE.NKIGGDGSLTRIRARFKN.GLMSPERIQQQQQqhilpsdaksntdlcsntelkdapfenDLPRAKLKGKNLLVELKKEEEd.......vgNGIESLTKSNTKLNSML.....ANEGKI.....-HKASFQKSVKFKLPDNI.......vTEETVELKEIKDLLLQMLRRQREIESRLSNIE--lq....................................
A0A1G4KIZ7_9SACH/26-259             .............hgdhls--------TS.....PARNVYRS..LSTSPAKKMQAR...DLTQPA.RRLS....PKKRSREg.....dfEAGFQTTP..KRLQS.PTSL.QDHLK......NLgTVSV...DRVKF....E-------...-K..........DNSAVKKLKFPVSPAKTQ...FSSS.QTLGGDGSLSRIRTRFGG.GLKSPQRALSGKE..........................dHQRPVDATQRILTSKLDAEAD..........--KPSIKSMGFDVIHQKa..phLRFGSP.....-EPAPNRKRVKFELSNDP........MELKKEVSELRSLLEELNKRQDELEARLSRLEER......................................
C5DVF6_ZYGRC/15-254                 ...................NTRTSSHSPS.....TQGNVFKR..LGTSPSMRYPNG...-LSKPP.ARVS....PARKSPV........KPLLQLTP..KRIQS.PECL.REYNP......KF.MHSG...GSPSI....-DDNLTSK...VE..........NRGSTTSILFPTSPTRTI...FANE.RKIGGDGSLGRIRSRFTN.GLLSPQKRLAPTPmknrleh............amesdntsDNSNNELQAKNLFEKLKEAEK..........--MEQET----------.....-NQERS.....-KTQPHKKSVKFELPRKDs......kEALKKELQALKELLKEATRRQSELEVRLSKLEE-g.....................................
A0A0C7MTG6_9SACH/4-252              ............htierql-------RGS.....PTKNVFKR..LSTSPNKKLLPN...TNRKSS.SKLS....PERGQNAw.....erPVVYQATP..KRLKS.PPYL.LDLKP.....pGG.TLSV...DRVHF....KNDPE---...--..........--DNSIQLSFPTSPVRTT...YSNS.TASGGDGSLSRIRTRFGG.GQRSPGKVSNATL..........................sAVTTTVNSARNLLPELQEQDEvalenksssgNDYDNYK-HRSSLPKIS.....ANDGFKi..rkPRSLNPKKSVKFESDMAE........NDVQEQLSKIVSMLLEIMERQDRLEAKVSSMD--rv....................................
Q6FXC3_CANGA/6-256                  ..................s-DIGNVVQGR.....DTRNVFDR..LSISPQKRSSNKrdsVVWKPA.SRIS....PKKSNNAp......lTTAIHETP..KRLQS.PSFL.KDR--......SF.TQSL...DRPQFd..pKDIVSATP...VNkvkpgiprsvGNPTTSTFMIPISPTKIT...FSNE.KRTGGDGSSSRILSRMRN.IRASPVRSVPSTA...........................----TTIKKRNLTERLRQEEE.........gENKNNEKRVRFQVPSQP.....-RPGSS....qSSSRTPSRDSNESMTNAN........KHISRERKAPMPVKTSPDARIDQLENTVRLLEER......................................
G8JTI2_ERECY/17-247                 ...................NDISNKDTSN.....RGSNVFKR..LSTSPMRKPGLS...VIDKPA.VRLS....PT-----........KSSYQTSP..KRLIP.PEHL.S----......NV.TRSV...DRHHFi..kRPEHTSSL...IQ..........SLHGGADIVIPISPIKMEsekFGSV.TTVGGDGSLSRIKNRF--.---SPSKDRKSIMt.........................vNEETLSPTRQNLLNKLQRDED..........--LSKVTKKNTKLNSELi..snFKVGKS.....-QITTRSKNVKFELPED-........RMIAIELQNLKQLLQMLLERQDRLELKIAELESK......................................
A0A1G4JIE6_9SACH/4-257              ............ddgdsrl-------RGS.....PSKNVFKR..LSTSPVKKMSTN...-LNKSG.IRAS....PLRRKPNw.....dhTIGFQTTP..KRLKS.PPYL.QSFER.....sAG.TVSV...DRVHF....---SND--...--..........PNDESIKLSFPTSPVRTT...YGNS.VAPGGDGSLSRIRSRFSG.GQRSPSKALDSARs........................tkSLQALSKSTRNLLPELQEHDSeinh.itaveDNSPNITRQNTLLNSALp...pNRDRPNfkikkPHSPHRHKTVKFEPITNE........KEIKEQLTNISALLAKVMERQDQLEAKLNSI---ghg...................................
A0A1X7R617_9SACH/79-184             ppqndhsrsnppsilkqgp----------.....--------..------------...------.----....-------........--------..-----.----.-----......--.----...-----....--------...--..........------------------...----.------------------.-------------...........................PTSSSRLGGNNLLNKLREEES..........--------ISSRVDKIM.....NENKKR.....YKSKMEEKNVKFYLPTD-........DNIREEVDSLKSMLEHIISRQDTLEKSIEEIK--sl....................................
H2AR55_KAZAF/79-203                 .........hlspvrthas----------.....--------..------------...------.----....-------........--------..-----.----.-----......--.----...-----....--------...--..........------------------...----.-----------LRSSHGV.TIVSPIRANLQDQy........................skDELKEEVKGSNLLTKLKDEFS.........gEPHGNEATYHAPLPQNS.....DSNTRS.....-SASQPKKAVKFALSNE-........---NSTEEDLRSLIEQMKDNQLTLEKKLDSLT--se....................................
J8PJT9_SACAR/15-285                 ..................n-TIGRNNLPS.....NKNNVFVR..LSMSPSKTIGQR...EFLKPP.MRLS....PKKTDAS........KHSIQVTP..RRILS.PECL.KGYIP......KV.TQSL...DRPQF....KNTSKDAK...IE..........NSDHMTNIIFPTSPTKLT...FSNE.NKIGGDGSLTRIRARFKN.GLMSPERIQQQHQqqifqpqatnstdiddndefkvnpfegELPQDKLRGKNLLSELKKEDEg.......vgNGVESLTKSNTKLNSML.....AKEGKV....qKQKAGFQKSVKFKLPDNV.......vNEETVELRDIKDLLLQMLRRQREIESRLTNIEHQ......................................
C5DMZ2_LACTC/14-262                 ............hddqaah------LQGS.....PSKNIMKR..LSTSPVRKM--P...VISRSS.ARLS....PVRPSHSr.....elPMYLQTTP..KRLKS.PPSL.QSYRP.....vSG.TVSV...DRAQF....KNNL----...--..........-ADKSVQLSFPTSPIRST...YSNS.TTTGGDGSLSRIRARFGS.GLRSPQKPTNKDYalpgpp...............knllpqLEEESEDPERNSSAKLNENAL..........ESDNEVSKSIMKRHGSQ.....NGSQVT.....KPKLQARKSVKFELSSREg......nDQIMKKLSQMTQMLAKVMERQDQLEAKLDAMQ--ha....................................
J4TT80_SACK1/15-282                 ...................NKIGRNNIPS.....DKDNVFVR..LSMSPSKTAGQK...GFLKPP.MRLS....PKRTDVT........KHSIQVTP..RRIVS.PECL.KGYIP......KV.TQSL...DRPQF....KNTSGDMK...VQ..........SSDHITNLIFPTSPTKLT...FSNE.NKIGGDGSLTRIRARFKN.GLMSPERIQQQHQvpqilpsqakngt.gvtdepnensydnELSQDKLKAKNLLSELKKEEEd.......lgNGIESVTKSNTKLNSML.....AKEGKV.....-QKASFQKSVKFKLPDNIv......tTEI-AELRDIKDLLLQMLRRQREIESRLTNIE--lq....................................
G0VBX4_NAUCC/1-227                  .................mk-------EYS.....TKKDVFRR..LSNSPTKNKVAK..lSVSSSK.VQNF....PITSRTS........PIRNIKTH..ARLTS.PKCL.KDYQP.....tML.VQSV...DRHHF....--------...--..........-NEGRGDLNFLTSPTK--...FNLE.KTVGGDGSRTRIRSRFKN.GLLSPERLQNERE..........................qLSPSKHIQGSNLFTKLKREDE.........eWDMDKLTEINTSHNKKS.....-EDSPT....yIPLSPNKKNVKFELPITTr......dQEINDSLKDIKSMLINVIKKQDEMNSRISQLED-t.....................................
A0A7H9B839_ZYGMR/20-256             ........sdlsvtsknqv---------F....cTNSTAVKR..LGDSSSKVHISD...-LSKPP.GRLS....PVRKGP-........--ARQLTP..KRLAS.PTCL.KDQ--......ST.TDFR...DRSLP....PNSNRSE-...-E..........EDKHATSLIFTTSPTKLL...FSSD.KKIGGDGSLSKLRSRFSN.GLLSPQRLSTVPG...........................--SSKEVKGKNLLSKLQDQEY..........KSPKNETSTHTQNNETKs...lSQEGRV....tKSQQQRKKTVKFKVPDAEk......dTLIETELADLKSLLLQVLKHQKVLESKLINLEN-n.....................................
A0A1S7HK91_9SACH/15-255             ..................n-VRTTSHSPS.....NYNHGLKR..FATSPASRHLND...-LSKPP.ARIS....PSRKTPM........KHSIQLTP..KRLPS.PECL.KEYKT......KR.LKNT...ESPLM....HPEVTDV-...-E..........QRGSSTTVVFQTSPTRAI...FSNE.RKIGGDGSLGRIRSRFGN.GLLSPQRRIVPAPrq......................kalNPEEKELEAKNLFEKLEEAEK..........-----LERTHSDLTSDDd...rAKDAKA....pKSVQCSKKSVKFELPLEDt......rEKILEELHEVGKLLEEAFKRHRELELRLAKFEHQ......................................
A0A1S7HGQ8_9SACH/15-260             ..................n-VRTTSHSPS.....NYIHGLKR..FATSPASRHPND...-LSKPP.ARIS....PSRKTPM........KHPIQLTP..KRLPS.PECL.KEIKT......KR.LKNT...ESPLM....HPEVAEV-...-D..........QGGSSTTMVFQTSPTRAI...FSNE.RKIGGDGSLGRIRSRFSN.GLLSPQRRIVPAPkq......................kalNPEEKELEAKNLFEKLEEAEKl........eKSHSDLTCDNPKRNDDG.....GKDAKA....aKSVQCSKKSVKFELPPEDt......rIKILEELHEVGKLLEEAFKRHRELELRLAKFENQ......................................
G0WGS5_NAUDC/22-283                 ..............mstnn----NHRSNSk..lhPTKDVFKR..LSLSPSRNDKTSkpqSHYKNE.KRISlslsPIRIQET........ARHLGSPP..KRLVSfPHHLeKTYRD......SI.SDSLlsnTREHL....PNHDDDDD...DD..........DDDDNELLYFPTSPTK--...FNID.KTVGGDGSRSRIRSRFKN.GLMSPERIQSERDps......................slsPLRASPSKNKNLLQKLEREND..........--LDTLTEMNTLHNSRK.....DTHGDS.....--SMIPKKRVKFHVPSSRtpeedgknEAVLQQLEEAKDMLIKIIKKQDDLEIRMSRIEH-s.....................................
A7TJ22_VANPO/10-269                 ...................NKVGNEKDGSfp.shRDNNVFKR..LTLSPPKKYLSK...PSSNSP.SRLP....VSTSGNVk......gKYGIQVTP..KRIAS.PDCL.KDFNV......K-.---I...DQPLM....MTDSGSKKrsvLV..........DTDSVTKVTFPTSPIKIK...FAET.KPLGGDGSLNRIRAKFKN.GLMSPERHNAGSTsilh..................sepinEIRPSLRAGRNLFKELQREDSig......seEDYNSVTKRNTSYNASM.....KKSGSI.....TKSSPMKKSVKFAVPSDDq.....eySELKSELSDIKNLLLSLVNKQTSIESRLSQLEEQ......................................
A0A1X7R617_9SACH/1-78               ..................m-------SES.....QSSDVFRR..LQISPSKNNA--...-IKKPA.LRLS....PRKVSR-........TRDLQYTP..SKYES.--HL.NPD--......MF.TKSL...DRSS-....--------...--..........------------------...----.------------------.-------------...........................---------------------..........-----------------.....------.....------------------........----------------------------------klligkipshdng.........................
Q6CJB4_KLULA/24-230                 ...............qels----SNASPPs...sASGEIFKR..LSVSPNRNR--K...LLEKPA.ARLS....PQQ----........---RVQTP..KRLPS.PDIL.-----......GP.NLSL...DRYER....----QKS-...--..........SVVKINEIVFPNSPTKASg.aLRNV.PVLGGDGSLSRIRNRFKI.NNASPV-------...........................--------KANLLDKLNKEET..........ETDTAKRKRKTDTPNAMk...gSRVEKN.....-ERRTRSKSVMFKLPED-........RIISIELNEMRKLNEALIARIEELEQRMARLEDR......................................
G8ZX91_TORDC/12-250                 ..........dinnlmepp---------Ste.rlHQSNVFKR..LSTSPSKAYAND...-LSKPP.VRMS....PVKRSPS........KSGNQLTP..KRLAS.PDCL.KNDVS......KI.TQSM...DRPYF....EKHGGNPK...IE..........DSGSVTNLVFPASPTRVT...FSNE.RKIGGDGSLSKLRSRFTN.GLLSPQRGA----...........................NMPKTELQGKNLFSKLENDEQ..........--INDFTTSPKRRLENL.....EEEAIS....sNKRKQIKKTVKFELPASDe......nENLRKQVQDLKHTLSKVIEHQNEMEVRLKLVESQ......................................
A0A7H9I0N7_9SACH/11-251             ............qditnvm-------EQStd.lsHQSNVFKR..LSTSPTKAYPDD...-ISKPA.MRLS....PVKRSPN........KIRTQMTP..KRLVS.PECL.KNYIP......RI.TQSM...DRPHF....NREERVQK...YE..........EDGSVTNLVFPSSPTKMA...FRSD.KKIGGDGSLSKLRSRFSN.GLLSPQRFANGTS...........................----SRFQGTNLFSKLEEEAE.........eAEKDSERMLNFKRELAH.....TQDHSK.....ISKKRLQKTVKFQIPATDg......eSDMTARVNYLELTLSQVLKRQKELEDRLMMMEQ-r.....................................
G8BR78_TETPH/10-257                 ..................n-SSTSKRSESlnhagKGITDFKKnsLQKDPVRSILKS..sRLFKSP.EKLN....NCKVSK-........KSTLHITP..KKLAS.PECL.RDYIP......KV.TRSV...DYSDF....RKMHEPI-...IE..........TNGTVTNVLFPTSPLKIR...FSDSiKPIGGDGSLNRIRAKFKN.GLMSPEKLIQRKG...........................TSIITSKARRNLFEEIQRESTs.......ttIDTNKIKTIQKSLNNGI.....LKKEIQ.....-KGESPHKSVKFHIPDNE........SDIRQQLNDINNLLNAILTRQDVLEKEISEIKR-n.....................................
#=GC seq_cons                       ..........................psS.....sppsVFKR..LuhSPs+ph.tp....lpKPs.hRlS....Pt+tss.........phshQhTP..KRLhS.PppL.+sh........ph.TpSl...DRsph.....ptsts.................tsspssplhFPoSPs+ht...Fusp.pplGGDGSLoRIRuRFps.GlhSPp+h.t.t...............................tsphpt+NLhs+Lpc--p............hsphsphpsphspth.....tppsps......ptts.cKsVKFcLPss.........pplppcLpclcplL.phhcRQcpLEt+lsplE........................................
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