GenomeNet

Database: Pfam
Entry: FKBP26_C
LinkDB: FKBP26_C
Original site: FKBP26_C 
#=GF ID   FKBP26_C
#=GF AC   PF18046.4
#=GF DE   FKBP26_C-terminal
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF04870
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.20;
#=GF NC   26.70 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0487
#=GF RN   [1]
#=GF RM   21262232
#=GF RT   Structural analysis of protein folding by the long-chain
#=GF RT   archaeal chaperone FKBP26.
#=GF RA   Martinez-Hackert E, Hendrickson WA;
#=GF RL   J Mol Biol. 2011;407:450-464.
#=GF DR   INTERPRO; IPR040825;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the C-terminal domain (CTD) of Methanocaldococcus
#=GF CC   jannaschii peptidyl-prolyl cis/trans isomerase FKBP26. FKBP26
#=GF CC   mediates protein folding. CTD has an alpha/beta-sandwich
#=GF CC   structure composed of three alpha-helices and a three-stranded,
#=GF CC   mixed-orientation beta-sheet. The CTD domain is responsible for
#=GF CC   dimerization of FKBP26 by through inter-subunit antiparallel
#=GF CC   pairing of the third beta-strands of the two CTDs. The CTD dimer
#=GF CC   forms a continuous, six-stranded mixed beta-sheet. A CTD-like
#=GF CC   structure is also found in the phylogenetically conserved NifU
#=GF CC   proteins (HIRIP5 in mouse and humans) [1].
#=GF SQ   86
#=GS A0A1Y3GBV7_9EURY/152-221  AC A0A1Y3GBV7.1
#=GS B5IDN3_ACIB4/155-224      AC B5IDN3.1
#=GS A0A2K5ATF2_9ARCH/155-225  AC A0A2K5ATF2.1
#=GS A0A0N8VLE8_9ARCH/153-222  AC A0A0N8VLE8.1
#=GS E6N7B6_CALS0/182-253      AC E6N7B6.1
#=GS A0A166DPH6_9EURY/155-231  AC A0A166DPH6.1
#=GS K0IE41_NITGG/154-224      AC K0IE41.1
#=GS A0A557SSP9_9ARCH/155-225  AC A0A557SSP9.1
#=GS S6A5B8_9CREN/157-227      AC S6A5B8.1
#=GS E6N422_CALS0/166-237      AC E6N422.1
#=GS A0A328PIJ9_9EURY/154-230  AC A0A328PIJ9.1
#=GS A0A165ZQL6_9EURY/155-231  AC A0A165ZQL6.1
#=GS Q2NHZ2_METST/155-232      AC Q2NHZ2.1
#=GS A0A0U3FM58_9CREN/156-221  AC A0A0U3FM58.1
#=GS I3D3C2_9ARCH/157-227      AC I3D3C2.1
#=GS A4YIZ2_METS5/155-222      AC A4YIZ2.1
#=GS A0A1D2WDT1_9EURY/155-227  AC A0A1D2WDT1.1
#=GS A0A166F332_9EURY/155-231  AC A0A166F332.1
#=GS A0A328SS88_9EURY/155-232  AC A0A328SS88.1
#=GS A0A366M9X5_9EURY/155-231  AC A0A366M9X5.1
#=GS A0A2R4ZQP6_9CREN/141-214  AC A0A2R4ZQP6.1
#=GS A0A484IGA4_9ARCH/155-225  AC A0A484IGA4.1
#=GS A0A2T9WXL1_9CREN/155-228  AC A0A2T9WXL1.1
#=GS A0A2U0S2N1_9ARCH/155-226  AC A0A2U0S2N1.1
#=GS M9SIM9_METAX/155-223      AC M9SIM9.1
#=GS Q12Z11_METBU/155-222      AC Q12Z11.1
#=GS A0A2T9WPQ0_9CREN/155-228  AC A0A2T9WPQ0.1
#=GS A0A0Q4BAX0_9ARCH/163-221  AC A0A0Q4BAX0.1
#=GS V6AVQ0_9ARCH/155-225      AC V6AVQ0.1
#=GS D3DZS3_METRM/155-231      AC D3DZS3.1
#=GS R9SLU5_9EURY/155-231      AC R9SLU5.1
#=GS E0SPF3_IGNAA/156-229      AC E0SPF3.1
#=GS A2SSL2_METLZ/150-219      AC A2SSL2.1
#=GS E3GY74_METFV/155-230      AC E3GY74.1
#=GS A0A5B2YYZ7_9ARCH/155-225  AC A0A5B2YYZ7.1
#=GS R9T5D9_METII/159-227      AC R9T5D9.1
#=GS Q8PTQ7_METMA/155-222      AC Q8PTQ7.1
#=GS A0A060HPH9_9ARCH/146-216  AC A0A060HPH9.1
#=GS Q8TM55_METAC/152-219      AC Q8TM55.1
#=GS A0A2H1EF22_9ARCH/155-225  AC A0A2H1EF22.1
#=GS S2EQP4_9ARCH/157-226      AC S2EQP4.1
#=GS F0T905_METLA/155-232      AC F0T905.1
#=GS A0A110A2M7_9ARCH/154-222  AC A0A110A2M7.1
#=GS A0A484F790_9EURY/152-219  AC A0A484F790.1
#=GS A0A0A7LFF6_9ARCH/156-224  AC A0A0A7LFF6.1
#=GS A0A328RZQ5_9EURY/155-232  AC A0A328RZQ5.1
#=GS F4B744_ACIHW/155-226      AC F4B744.1
#=GS G4RLU4_THETK/155-228      AC G4RLU4.1
#=GS A0A510E3V1_9CREN/155-225  AC A0A510E3V1.1
#=GS A0A2U1S7E3_9EURY/155-231  AC A0A2U1S7E3.1
#=GS D7EAT7_METEZ/152-219      AC D7EAT7.1
#=GS F6BC85_METIK/152-222      AC F6BC85.1
#=GS A8A8J0_IGNH4/156-222      AC A8A8J0.1
#=GS A0A2T9X054_9CREN/155-226  AC A0A2T9X054.1
#=GS A0A0A7V5A4_9ARCH/155-225  AC A0A0A7V5A4.1
#=GS E1QR17_VULDI/155-228      AC E1QR17.1
#=GS A0A0W7THT1_9ARCH/155-223  AC A0A0W7THT1.1
#=GS A6UX29_META3/152-223      AC A6UX29.1
#=GS A0A0Q4BIQ8_9ARCH/153-221  AC A0A0Q4BIQ8.1
#=GS FKBPL_METTH/154-231       AC O27197.1
#=GS I0A208_FERFK/158-231      AC I0A208.1
#=GS D7DRN0_METV3/151-221      AC D7DRN0.1
#=GS A0A2H5V0X8_9ARCH/171-242  AC A0A2H5V0X8.1
#=GS A0A1D3L4N9_9EURY/155-232  AC A0A1D3L4N9.1
#=GS A0A2V3JT35_9EURY/151-217  AC A0A2V3JT35.1
#=GS A0A2H5VFY3_9ARCH/154-221  AC A0A2H5VFY3.1
#=GS A0A0F7IG50_9EURY/150-217  AC A0A0F7IG50.1
#=GS FKBPL_METJA/152-221       AC Q58235.2
#=GS FKBPL_METJA/152-221       DR PDB; 3PRB B; 152-221;
#=GS FKBPL_METJA/152-221       DR PDB; 3PRD A; 152-221;
#=GS FKBPL_METJA/152-221       DR PDB; 3PRB A; 152-221;
#=GS A9A2U9_NITMS/157-227      AC A9A2U9.1
#=GS A0A1Q6DXQ9_9EURY/152-221  AC A0A1Q6DXQ9.1
#=GS A0A1V6N086_9EURY/155-231  AC A0A1V6N086.1
#=GS Q6LZQ2_METMP/151-221      AC Q6LZQ2.1
#=GS A0A328SE59_9EURY/155-232  AC A0A328SE59.1
#=GS A8MBW1_CALMQ/155-226      AC A8MBW1.1
#=GS A0A2R6T5H3_9ARCH/146-216  AC A0A2R6T5H3.1
#=GS Q975S7_SULTO/155-227      AC Q975S7.1
#=GS Q8ZYF3_PYRAE/155-226      AC Q8ZYF3.1
#=GS A0A4E0PZF3_9EURY/156-222  AC A0A4E0PZF3.1
#=GS A0A6A7LFU3_9ARCH/155-225  AC A0A6A7LFU3.1
#=GS A0A6A8FK82_9ARCH/155-225  AC A0A6A8FK82.1
#=GS A0A329D4V1_9ARCH/159-229  AC A0A329D4V1.1
#=GS A0A2T9X450_9CREN/155-228  AC A0A2T9X450.1
#=GS D5EC51_METMS/152-219      AC D5EC51.1
#=GS M4YKQ7_THEXX/154-222      AC M4YKQ7.1
#=GS U6EF10_9EURY/155-231      AC U6EF10.1
#=GS A0A2H5UW89_9ARCH/163-234  AC A0A2H5UW89.1
A0A1Y3GBV7_9EURY/152-221             ...............DEEKIKALISLF..V..D..NLTADEFDLTLD..-E..E.VEIKVPRHANY....NMMWIYSKPRIVENIIEYM-DYDKVRLIEEY-t............
B5IDN3_ACIB4/155-224                 ...............DVDKVRAIIEMD..Y..G..K-EVEKFNIEVK..DD..D.IIIELPDVCKY....DSNWAVAKYAIVGDIRDYV-ANKNVKFVEVY-p............
A0A2K5ATF2_9ARCH/155-225             ..............d-MEKATALIRRR..M..P..-VDASKLGLSLN..SG..T.MEIMVPKEYYM....QEGLQIIKRAIANDIFRYVQSVKSIRFIEVYE.............
A0A0N8VLE8_9ARCH/153-222             ..............e-SEKVKAIIDME..Y..S..DAD--EFEVSLE..ND..I.INIQIPEKAKF....DVNWLDSKYRIANDIRKYIPDK----------dtiikelykr...
E6N7B6_CALS0/182-253                 .............dl--EKVKNLIHMH..F..P..DVSVEKFEVSLS..PP..L.LRVKIPEEAFL....APGIQLAKRALAKEFKEAVKGLEKVVFEEEY-s............
A0A166DPH6_9EURY/155-231             ...............EEEKIKGMIQLHyaY..P..NLDINKTEIRID..GK..K.VSIKLDDITKYdqksYMDITFARFRISKDIWENL-DYEKVEFIDEFE.............
K0IE41_NITGG/154-224                 ..............d-SEKVSALVRRR..T..-..GLEDSKVKINLS..AP..N.LDIELPEEAFL....AEGLQVIKRAIANDIFKFVPSVKNIKFIESY-y............
A0A557SSP9_9ARCH/155-225             ...............DNEKISNLISRR..L..P..-IDLTEVKYETK..ES..A.LEISLPENTFL....IEGIQIIKRGISTDIFKFIPSLKTIVFLEKY-a............
S6A5B8_9CREN/157-227                 ..............d-AEKIRELFHRW..F..R..NIPKENIKTEIA..GD..T.VKIEVPTSIFL....IENAFTLLSGFVRDVQRHFENINNVEFVA---kv...........
E6N422_CALS0/166-237                 .............dl--EKVKNLIHMH..F..P..DVSVEKFEVSLS..PP..L.LRVKIPEEAFL....APGIQLAKRALAKEFKEAVKGLEKVVFEEEY-s............
A0A328PIJ9_9EURY/154-230             ..............d-TEKVKSMIQLY..Y..PldKINLDKIQVEID..DG..T.VKIYMDELSRFdrrpYMDVTLSRFRIARDIWENM-DIKKVEFVDVF-t............
A0A165ZQL6_9EURY/155-231             ...............DEDKIKSLIQLHyaY..P..NLDVEKTALNFD..GK..T.VAITLDDITRFdqksYMDVTFQRFRIAKDIYENL-DYDNVQFVDEFK.............
Q2NHZ2_METST/155-232                 ...............NVEKIKGLIEVY..YgnP..NIDLEKTEILIE..DG..V.AKITLDKLAGFeqrsAQEITLSKFRVARETYENIDEIEKVQFIDEYE.............
A0A0U3FM58_9CREN/156-221             ...............EKEKIKALVKR-..-..-..RMK--DAEVEIS..DG..K.VVIKVPEKYLL....AEGLQLAKLSIVNDLF-RYTNVKEVAFIEEIK.............
I3D3C2_9ARCH/157-227                 ..............p-SDKIDSILKNR..L..P..VED-AKISFDLK..DK..E.VSIVIPEEILR....ADGLQIMKHFIQLDIFKFVPTLEKVNFVET--hv...........
A4YIZ2_METS5/155-222                 ..............v-KEKIQALINRW..F..S..GVELPSAELSED..QK..T.LKITIPEKIFL....LEDLQTRKLLLARDIIKYV--LEDV-------vvvyq........
A0A1D2WDT1_9EURY/155-227             ..............d-TEKVYGIIELQ..YpnP..NIKPEDHEVKME..DG..K.VMIYLNEMAKF....DNQITYAKFRIARDIWDNM-GIDRVEFVDVFE.............
A0A166F332_9EURY/155-231             ...............DEEKIKSMIQLHysY..P..NMDLDKTEIKID..SD..K.VSIKLDEITRFdqksYMDVTFARFRISKDIWDHM-DFEKVEFVDEFE.............
A0A328SS88_9EURY/155-232             ...............NEEKIKGLIEVY..YgnP..NLNLDEVKIDFE..DD..I.AKLNLGLLAGFdqrsSQEVTLSKFRVAREIYENIEEIETVQFIDEFK.............
A0A366M9X5_9EURY/155-231             ...............DEEKIKSMIQLHysY..P..NMDLNKTEIKID..GD..K.VSIKLDEITRFdqksYMDVTFARFRIAKDIWDNM-DFEKVEFVDEFE.............
A0A2R4ZQP6_9CREN/141-214             ..............p-VEKIKHLIARR..S..R..RINIEGLNVKIS..QDmiK.VEIETPEEILL....AEDLQIFKKAVAEDIFKYFPEVKQVAFIDSF-f............
A0A484IGA4_9ARCH/155-225             ...............DDEKISNLIKRR..L..P..-IETQEVKFEIK..DS..D.LEISLPENTFL....IEGIQIIKRGISADIFKFVPSLKNIIFVEKY-t............
A0A2T9WXL1_9CREN/155-228             ...............TEDKIRYLIRQY..I..P..RIDPGKINVELSqdGS..V.VTIKLPVETLF....MENMGTIRARIADDIGNRFTNINKVVFIDEIE.............
A0A2U0S2N1_9ARCH/155-226             ...............NEEKVSALIHRR..V..S..AVEVEKFDFKIG..KA..N.VTVNMPDESFY....VEGIQLAKRGIAMDIQRFVPELTTVQFVESF-v............
M9SIM9_METAX/155-223                 ...........ndkk----ATAIVEAD..F..G..NAD--DFKFEFP..GD..K.VVVTLPEITKF....HQEWPVARFRVVSDLREAF-GVDTVEFVEI--ws...........
Q12Z11_METBU/155-222                 .............pi--EKVKGLLALYtgV..P..DLE-----VAIE..DN..K.VSIEVPAMLSF....NQRWLMAKGRVASELIEHL-GLEKVSYIESY-p............
A0A2T9WPQ0_9CREN/155-228             ...............EKDKINALIERW..L..G..SSVAQKFVVEISedKK..T.VKVTIPKDIYL....VEDLQLRLYMLAKDIINFVIQEGNVSFIENF-n............
A0A0Q4BAX0_9ARCH/163-221             .........mdfgts------------..-..-..----DGFEFEFD..EK..K.VSVRMPDLVKF....NQGWPMSKFRIVSDLRDSF-GVDTVEFIETW-t............
V6AVQ0_9ARCH/155-225                 ...............NEDKISAILKRH..M..P..VED-SKIVSKLN..GN..I.LDVTIPEEIFG....AEGLRIIKHFIQTDIFKFIPTLEKINFIESY-s............
D3DZS3_METRM/155-231                 ...............DEEKIKSMIELHysY..P..NMDYDNIEIKFD..GS..T.VSIKLDEITRFdqqsYMDVTFARFRISKDIWDNM-DYEKVQFVDEFE.............
R9SLU5_9EURY/155-231                 ...............DEDKVKSMVQLHyaY..P..NMDIDKTEVDFD..DK..T.VNIKLDEITRFdqksYMDVTLARFRIAKDIWDNM-DVDKVQFVDTFE.............
E0SPF3_IGNAA/156-229                 ...............DVEKIKMLLHRR..Y..R..RIPIERFNVSIDqtKN..E.VVIELPREIYL....DRDLQLVKALVVEEIYRYIGKYNSIVFIERY-t............
A2SSL2_METLZ/150-219                 .............ga--EKLAGIIKL-..-..-..-LTGRDMKVDAE..DK..TfVSIEIPAMMAM...yNQNWLMTQYMVSQEAFAIFPEIENVKFVESF-p............
E3GY74_METFV/155-230                 ...............DKEKIKGIISMY..Y..P..NAKLEDINVEIK..DG..T.VSIEVDDTFKFdnrpHSNITLTQARIAKEIWDNIEGVKRVEFISAFE.............
A0A5B2YYZ7_9ARCH/155-225             ...............DDEKITNLIHRR..L..P..-IELSEIKFENN..ES..E.IQISLPENTFL....IEGIQIIKRGISADIFKFVPNIKSVIFLEKY-d............
R9T5D9_METII/159-227                 ...............DDEKIEGILKMD..Y..G..TSE--GFSISIS..EN..V.IEIVLPDVCKY....DSNWGMAKYRVIADLREAL-GDKNVRFVEEY-v............
Q8PTQ7_METMA/155-222                 ...............DVEKVQGLLALY..T..-..GIR--DMEVEIA..DD..A.AKINVPTGLTF....NQRWLMAKNRVASELFK-YAGLKEIQFIEK--lt...........
A0A060HPH9_9ARCH/146-216             ...............DNDKITALIKRR..I..P..IED-AKIKFNLS..GA..N.LDMELPEETYM....AEGLQIIKRAVANDIFKFVPAVKNIKFIENY-a............
Q8TM55_METAC/152-219                 ..............d-VEMIQGLLALY..T..G..-MR--DMEVEIT..DG..V.AKIYVPTGLTF....NQRWLMAKNRVVSELFK-YAGLKEVQLIEK--lt...........
A0A2H1EF22_9ARCH/155-225             ...............DQDKVMGLLKRR..F..P..-IDESKIKFEIK..AT..A.VDVTIPEEAMM....MDGLQIVKRAIANEIFKFVPKLEKVNFVDSY-n............
S2EQP4_9ARCH/157-226                 ..............p-NDKVDGILKNR..L..P..LED-SKITFELK..DK..E.VNITIPEEILR....ADGLQIMKHFIQLDIFKFVPSLEKVNFIET--h............
F0T905_METLA/155-232                 ...............DVEKVKSMIELH..YkaP..NLDSDKHDIQIE..DG..V.VRIAMDEMAKFdkqpYMDVTFARFRISRDIWENIENIEKVEFVDVFE.............
A0A110A2M7_9ARCH/154-222             ..............d-AEKAKAIIEAD..F..A..AAD--DFKFEFP..GD..K.VVVTLPEITKF....HQEWPVARFRVVSDLRETF-GVDTVEFVEI--ws...........
A0A484F790_9EURY/152-219             ..............a-EEKINGLFALY..T..G..---VQDADVKVN..GD..V.ADIEIPTGITF....NQRWLFSKGKLANEILENT-DLKEIRFIESV-k............
A0A0A7LFF6_9ARCH/156-224             ..............p-EDKAKAILEV-..-..D..FGDSEGFSFAFP..EG..K.VVVTLSEITKF....HQDWQVARFKVVTDLREAF-GVDTVEFVEVW-s............
A0A328RZQ5_9EURY/155-232             ...............NVEKILGLIEVY..YgnP..NLNFDDIDIEIE..DG..I.AKINLGLLAGFeqrsAQEITLSKFRVAKETYDNIDEVDKVQFIEEFE.............
F4B744_ACIHW/155-226                 ...............EKEKIQALVERW..F..G..ENN--KMTFELTedKK..S.VKFEVPKDYFL....LEDLQTRKYVLAKDIITFVLPESVVSFVENY-n............
G4RLU4_THETK/155-228                 ..............s-EERVVYIVKQY..M..P..RIAPDKISASFS.qDG..TeLNVRLPAEVLL....YEKIGNILLQIASDLSGRFENLKKIVFSQE--ve...........
A0A510E3V1_9CREN/155-225             ...............QEDKVKAILGKW..F..K..KSG-EKIGVDMS.tEK..K.VKLTMPKELLL....VENIQLLKYVAAKDIVKF--------------vlpehavlyeeef
A0A2U1S7E3_9EURY/155-231             ...............DEEKIKSMIELH..YpsP..NMDLDKTVIDID..GN..V.VNIQLDEIAKFdqkpYMDITFARFAIAKDIWSNM-DFDKVNFVDAFE.............
D7EAT7_METEZ/152-219                 ..............d-DEKLQGLLALYtgM..P..EMD-----AKIE..NN..T.AIINIPNELTF....NQRWLMVKGRIASELMQHL-GIEEVQYVEKY-p............
F6BC85_METIK/152-222                 ...............PEEIVKELVKMY..M..P..SINTDDLKIKMT..KK..T.VTINLPEVCSF....MNNIQTIKMAIANEIIKRL-DVDKVSFVETF-v............
A8A8J0_IGNH4/156-222                 ...............PKDKVEYLIKRR..L..P..EAE-----MKYE..DG..A.VTITLPLKYIL....ADNIQAVKVVLADEIFKWVPEVKEVKFVEPIK.............
A0A2T9X054_9CREN/155-226             ..............e-ESKFKALLERW..F..G..KKTSELIRFTIN..GK..E.VVVDVPKEILL....SENLQLRKLMVSRDYINFVDAEAKVVFRETF-s............
A0A0A7V5A4_9ARCH/155-225             ...............DDDKVTEILKSR..L..P..VEN-DKINFKKT..GG..V.VDITIPEEIYR....ADGLAIIKHFTQMDLFKFVPALTKVNFVESYE.............
E1QR17_VULDI/155-228                 ...............TEDKVKYIIKQY..I..P..RIEINKVRVELGegGS..I.VTIKLPIETLF....MENIGTIKARIADDIGSRFTGVNKVVFVDEIE.............
A0A0W7THT1_9ARCH/155-223             .nnakaaaiieadfg------------..-..-..D--ASDFKFEFP..GD..K.VIVTLPEIVKF....NQTWVTARFRIVSDLREAF-GVDTVEFVEI--wa...........
A6UX29_META3/152-223                 ...............PEEIIKELIKLY..A..Q..KINTDDIAIKLT..KK..T.ATITLPESASF....LQNLQMIKMAVANEAMARINGMEKVSFVDVFE.............
A0A0Q4BIQ8_9ARCH/153-221             ...............DEEKVKAVLDMD..Y..G..TSE--GFDVTVE..DK..V.ISIVLPDVCKY....DQKWLLAKYRVVADLREAM-NATNVRFIEEY-v............
FKBPL_METTH/154-231                  ..............d-AEKVKSMIQLH..YpsQ..NMDIDKTEVKIE..DG..K.VIIHMDEMTRFdnrsYMDVTLARFRIARDIWENIEGVEKVEFADVFE.............
I0A208_FERFK/158-231                 ...............DDEKVKALLKRR..L..R..PKNIDDYNIKISkeEG..F.VQIKIPETEMI....NPDIQLAKRALAREIFNYIEGIKKVEFIEEI-i............
D7DRN0_METV3/151-221                 ...............QEDVAKEVVKLF..M..P..QLKAEELKAKVT..KS..T.VTVTLPEKAAF....IENVQMAKLGIANELMKRL-EVEKVSLVDTF-v............
A0A2H5V0X8_9ARCH/171-242             ..............e-RDKILGVVKML..F..P..EATDQNTHVEVS..KP..E.VSIRLPKESRT....VSGIQLIKQSIAREIFENIEGVTKVTFVDEY-l............
A0A1D3L4N9_9EURY/155-232             ...............DEDKIKSMIELH..YpnP..KIDIEKTEVTIE..DG..V.AKISMDEMAKFdnkpYMDITFARFRIARDVWENIDTIEKVEFVDVFE.............
A0A2V3JT35_9EURY/151-217             .............dl--DKIKSLLQSY..F..R..R----DFDVELV..DE..T.VMIEPPSDLRL....NQNWLLVKSGLANELLGSM-GLDSVKFVETY-q............
A0A2H5VFY3_9ARCH/154-221             ...............DNEKIKALIRRR..L..P..---LENIQFELK..E-..E.LRIIIPEEAFL....LEGLQIIKRAIANDIFKYLPNIKKVSFIESFE.............
A0A0F7IG50_9EURY/150-217             ..............p-EEKVKYLFLIY..T..G..R----ELVPEIE..DG..R.VVVEVPRDATF....NQYFLLGKFTVVDQIFKHLPEVKEVVFTEKFE.............
FKBPL_METJA/152-221                  ...............KKNIVKEIVKMY..V..P..RLS--DVKVTIR..NG..T.VKIELPEFAPF....IPNIQTAKMAIANEILKRLEDAEKVSFVETFE.............
#=GR FKBPL_METJA/152-221       SS    ...............HHHHHHHHHHHH..-..T..T------EEEEE..TT..E.EEEE--TTGGG....STTHHHHHHHHHHHHHHH-TTEEEEEEEEEEE.............
A9A2U9_NITMS/157-227                 ..............p-NDKVDGILKNR..L..P..VED-SKISFDLK..DK..E.VSITIPEEILR....ADGLQIMKHFIQLDIFKFVPTLEKVNFVET--hv...........
A0A1Q6DXQ9_9EURY/152-221             .............id--EKIKALISL-..Y..S..NTDTSEFKIDLA..DD..Q.VEIDVPERASY....DRSWLFSKKQIAEDIFDNT-EINTVRFVEEY-n............
A0A1V6N086_9EURY/155-231             ...............DEEKIKSMIQLHysY..P..NMDLDKTEIKID..GD..K.VSIKLDEITRFdqksYMDVTFARFRISKDIWDNM-DYEKVEFVDEFE.............
Q6LZQ2_METMP/151-221                 .........peaial------EVAKLF..I..P..RISEEDLKITID..GE..N.VTLDLPENTAF....MQNLQMVKMGISNELIKRL-EAKKVSFIDNF-v............
A0A328SE59_9EURY/155-232             .............vt--EKIKEMIDLY..YgnP..SLNLDDVEIEVE..DG..I.AKIKLGILAGFdqrsCQEVTMNKFRVASVLYENIDEIDKVQFIDEFK.............
A8MBW1_CALMQ/155-226                 ...............DEEKVKEIVRQY..L..P..RLDMSRVEAKHE..NG..Q.VTIKLPSEVLF....IEGIGTVKFRIAEELAQRFTDVKKIVYVEELE.............
A0A2R6T5H3_9ARCH/146-216             ............tsg---KIKALIDLY..G..Q..QINSDQFEVEIE..DK..V.ADISVPKSATF....SQGWMLSKRQIPQDVF-EYTDLKKVRFVEEYE.............
Q975S7_SULTO/155-227                 ..............e-SDKIKALIERW..L..G..SSYVDKLNMELD.eKK..N.VKFTLPKELYL....VEDIQIRKYMLAKDIINYVLPESTVTYIENY-n............
Q8ZYF3_PYRAE/155-226                 ..............l-EDKAVALLRIY..L..P..RVSADKIKATIE..GE..T.LTVTLPAEVLL....YERIGGVLLQYASEVSTKFQEVKRVRFIEEVE.............
A0A4E0PZF3_9EURY/156-222             ..............n-TEKVKGLVALY..T..-..G--LEDIETEIT..DD..L.IRIVTPIELSF....NQRWLVTKVNIATELIDRL-GIPNLEFVEK--h............
A0A6A7LFU3_9ARCH/155-225             ...............DDEKVKSLTRRW..I..P..LKD-DKIKFEIK..SP..I.LELFLPEETFL....LDGIQIIKGAVSNEIFKYVPSITSVKFIEEY-a............
A0A6A8FK82_9ARCH/155-225             ...............DNDKVLSLMKRR..L..P..LDD-EKIKFILE..GS..N.LTIQFPEETFL....TEGLQVIKRAIASDIFKYVGSITNVKFVETYK.............
A0A329D4V1_9ARCH/159-229             ..............d-DEKTSGILKRY..F..P..VKD-DKILFKKT..GK..T.LDITIPEEMLR....VDGLYAIKHFVQTDVFKFLPTLEKVNFIET--hv...........
A0A2T9X450_9CREN/155-228             .............el--DKVKALLERY..F..G..SSNVDKFAVEISndKK..E.VKIIVPKELYL....VEDLQSRIYVTAKDIITYVLPDASVSFTETF-n............
D5EC51_METMS/152-219                 .............di--DKINGLLSLYtgV..P..EIE-----VEVE..DK..T.AIINIPVALSF....NQRWLMSKNRIASEIIENI-GMEKVKFVETY-p............
M4YKQ7_THEXX/154-222                 dakkaeaiveadfgp------------..-..-..-A--DEFKFDFP..GE..K.VTVTLPEITKF....HQEWPVARFRVVSDLREAF-GVDTVEFVEI--ws...........
U6EF10_9EURY/155-231                 ..............d-AEKVKSLIDLH..YpnP..NLDSEKHQITIE..DG..K.VTIALDEMAKFdqrpYMDVTMARFRIARDVQENM-DITTVEFVDSF-v............
A0A2H5UW89_9ARCH/163-234             ..............d-GEKVKHIVHSR..I..S..EVPIEKFEIELS..PP..I.ARIKIPQEAHF....LPTLQVAKRAIAREVKEAVNGVEKVVYVEEF-s............
#=GC SS_cons                         ...............HHHHHHHHHHHH..-..T..T------EEEEE..TT..E.EEEE--TTGGG....STTHHHHHHHHHHHHHHH-TTEEEEEEEEEEE.............
#=GC seq_cons                        ................pEKlcullcha..h..s..phs.pchclcls..ss..p.VpIplP-tshh....hpslphsKhtlApDlhctl.slccVpFlEpa..............
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