#=GF ID Fervidolysin_NPro-like
#=GF AC PF22148.2
#=GF DE Fervidolysin N-terminal prodomain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Andreeva A;0000-0002-0450-0091
#=GF SE ECOD:EF25110
#=GF GA 21.00 21.00;
#=GF TC 21.00 21.00;
#=GF NC 20.90 20.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0570
#=GF RC Paper describing PDB structure 1r6v
#=GF RN [1]
#=GF RM 14687574
#=GF RT Crystal structure of fervidolysin from Fervidobacterium
#=GF RT pennivorans, a keratinolytic enzyme related to subtilisin.
#=GF RA Kim JS, Kluskens LD, de Vos WM, Huber R, van der Oost J;
#=GF RL J Mol Biol. 2004;335:787-797.
#=GF DR INTERPRO; IPR054399;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The founding member of this family is the N-terminal prodomain
#=GF CC of fervidolysin, an extracellular subtilisin-like serine
#=GF CC protease. This domain folds into a globular alpha/beta structure
#=GF CC consisting of four-stranded antiparallel beta-sheet and two
#=GF CC alpha-helices packed on one side of it [1]. The prodomain is
#=GF CC proteolytically cleaved and removed from the proenzyme.
#=GF SQ 1137
#=GS A0A0K9H0S2_9BACI/33-111 AC A0A0K9H0S2.1
#=GS A0A7D5L375_9EURY/40-122 AC A0A7D5L375.1
#=GS A0A4P8KZT1_9BACT/44-120 AC A0A4P8KZT1.1
#=GS A0A0A1PB48_UNCXX/40-125 AC A0A0A1PB48.1
#=GS A0A2W7MW04_9BACI/29-101 AC A0A2W7MW04.1
#=GS A0A0A8JHW2_BACSX/30-98 AC A0A0A8JHW2.1
#=GS L0A5H4_DEIPD/26-111 AC L0A5H4.1
#=GS A0A0J1HDW8_9GAMM/51-132 AC A0A0J1HDW8.1
#=GS A0A1Z5HSC5_9FIRM/29-111 AC A0A1Z5HSC5.1
#=GS Q2FNJ1_METHJ/21-109 AC Q2FNJ1.1
#=GS A0A942Z078_9BACI/41-116 AC A0A942Z078.1
#=GS A0A150WDK5_BDEBC/4-78 AC A0A150WDK5.1
#=GS A0A2T9YAY5_9FUNG/2-65 AC A0A2T9YAY5.1
#=GS A0A0J6FYF0_9BACI/28-105 AC A0A0J6FYF0.1
#=GS A0A919RZQ3_9CLOT/71-166 AC A0A919RZQ3.1
#=GS A0A0K9H9P7_9BACI/51-129 AC A0A0K9H9P7.1
#=GS A0A8F2B1B5_9BACT/631-708 AC A0A8F2B1B5.1
#=GS A0A523Q610_9BURK/28-116 AC A0A523Q610.1
#=GS A0A2V2MUK3_9EURY/43-132 AC A0A2V2MUK3.1
#=GS A0A931F9M7_9FIRM/177-241 AC A0A931F9M7.1
#=GS A0A829YLV3_9GAMM/25-106 AC A0A829YLV3.1
#=GS A0A1I3L6V8_9BACL/23-90 AC A0A1I3L6V8.1
#=GS A0A939GJQ3_9BACT/34-122 AC A0A939GJQ3.1
#=GS A5GD30_GEOUR/53-129 AC A5GD30.1
#=GS N1V7V5_9MICC/35-125 AC N1V7V5.1
#=GS A0A917CEB9_9GAMM/15-103 AC A0A917CEB9.1
#=GS A0A1Q3GNZ6_9BACT/114-180 AC A0A1Q3GNZ6.1
#=GS K6Y8B5_9ALTE/15-107 AC K6Y8B5.1
#=GS C7P049_HALMD/39-120 AC C7P049.1
#=GS A0A6B8RU53_9BACL/175-253 AC A0A6B8RU53.1
#=GS A0A6L6Q9A1_9BURK/25-96 AC A0A6L6Q9A1.1
#=GS A0AAD5GYX4_9CHLO/39-107 AC A0AAD5GYX4.1
#=GS A0A8J3HLF7_9ACTN/78-156 AC A0A8J3HLF7.1
#=GS A0A1S2QZC1_9BACI/48-125 AC A0A1S2QZC1.1
#=GS A0A6G8PXW4_9ACTN/40-122 AC A0A6G8PXW4.1
#=GS A0A2U3AQM0_9BACL/35-111 AC A0A2U3AQM0.1
#=GS A0A2P6TBI4_CHLSO/1219-1289 AC A0A2P6TBI4.1
#=GS E0IEB9_9BACL/33-113 AC E0IEB9.1
#=GS A0A2T6BS51_9BACL/22-100 AC A0A2T6BS51.1
#=GS A0A1L7BGE5_9BACT/35-114 AC A0A1L7BGE5.1
#=GS A0A1W6WM76_BACTU/21-102 AC A0A1W6WM76.1
#=GS A0A6M1UFZ7_9BACL/74-151 AC A0A6M1UFZ7.1
#=GS A0A1H4EF03_9BACI/36-117 AC A0A1H4EF03.1
#=GS A0A0M9DSN0_9BACT/124-200 AC A0A0M9DSN0.1
#=GS A0A5C5UPJ0_9BACL/36-118 AC A0A5C5UPJ0.1
#=GS A0A2T6C7S4_9BACL/22-105 AC A0A2T6C7S4.1
#=GS A0A8J3HLN0_9ACTN/26-108 AC A0A8J3HLN0.1
#=GS A0A5C1ABY4_9BACT/25-106 AC A0A5C1ABY4.1
#=GS A0A0S4LGL6_9BACT/41-121 AC A0A0S4LGL6.1
#=GS A0A514BQZ5_9GAMM/34-116 AC A0A514BQZ5.1
#=GS A0A2V2N4G8_9EURY/48-137 AC A0A2V2N4G8.1
#=GS A0A640VZI3_9RHOB/80-153 AC A0A640VZI3.1
#=GS A0A0M8JQ05_9CHLR/25-107 AC A0A0M8JQ05.1
#=GS A0A250VU99_STROL/132-190 AC A0A250VU99.1
#=GS A0A2I9D065_9DEIO/58-138 AC A0A2I9D065.1
#=GS A0A2N5MN50_9BACI/88-164 AC A0A2N5MN50.1
#=GS A0AA38Y0J1_9EURO/95-170 AC A0AA38Y0J1.1
#=GS A0A7G9SHX2_9SPHN/179-261 AC A0A7G9SHX2.1
#=GS A0A1J5NZH5_MOOTH/68-144 AC A0A1J5NZH5.1
#=GS A0A1M5QQH9_9BACT/45-124 AC A0A1M5QQH9.1
#=GS A0A916Z2D7_9BACL/214-292 AC A0A916Z2D7.1
#=GS A0A4R5H9H7_9ALTE/18-109 AC A0A4R5H9H7.1
#=GS A0A1H4REU7_9BACL/27-102 AC A0A1H4REU7.1
#=GS A0A4P7JKK6_9GAMM/21-100 AC A0A4P7JKK6.1
#=GS A5G6Q5_GEOUR/23-105 AC A5G6Q5.1
#=GS A0A0F3GWM6_9BACT/60-142 AC A0A0F3GWM6.1
#=GS A0A5K7YFL8_9BACT/20-101 AC A0A5K7YFL8.1
#=GS A0A0H4VJB7_9BACT/39-128 AC A0A0H4VJB7.1
#=GS A0AAE4CWZ8_9ACTN/8-88 AC A0AAE4CWZ8.1
#=GS A0A3A6TVK2_9GAMM/17-110 AC A0A3A6TVK2.1
#=GS A0A372LNH3_9BACI/50-125 AC A0A372LNH3.1
#=GS A0A086WC89_9BURK/26-94 AC A0A086WC89.1
#=GS A0A9W6L907_9BACT/35-110 AC A0A9W6L907.1
#=GS A0A087MGE0_9GAMM/28-88 AC A0A087MGE0.1
#=GS A0A345H3Z7_9FLAO/87-163 AC A0A345H3Z7.1
#=GS E8RAK6_DESM0/35-93 AC E8RAK6.1
#=GS A0A0P0CTG9_9BACT/38-126 AC A0A0P0CTG9.1
#=GS A0A411YKK2_9ACTN/47-127 AC A0A411YKK2.1
#=GS A0A329KTY0_9BACL/216-294 AC A0A329KTY0.1
#=GS A0A4Q0VVT5_9BACI/53-130 AC A0A4Q0VVT5.1
#=GS S2XMW6_9BACL/42-118 AC S2XMW6.1
#=GS I3EB43_BACMM/50-125 AC I3EB43.1
#=GS A0A160FFQ9_9BACL/47-122 AC A0A160FFQ9.1
#=GS A0A1Y5XUG3_KIBAR/23-100 AC A0A1Y5XUG3.1
#=GS A0A3S0BT43_9BACL/216-293 AC A0A3S0BT43.1
#=GS A0AA45C760_9BACT/44-120 AC A0AA45C760.1
#=GS A0A178KN50_9GAMM/4-94 AC A0A178KN50.1
#=GS A0A0M9UBM1_9CHLR/1266-1340 AC A0A0M9UBM1.1
#=GS Q8EIH2_SHEON/18-110 AC Q8EIH2.2
#=GS W4MD21_9BACT/2-76 AC W4MD21.1
#=GS A0A2B2BP02_9BACI/32-113 AC A0A2B2BP02.1
#=GS A0A6A7L0E5_9BACT/125-204 AC A0A6A7L0E5.1
#=GS A0AAJ1WJV0_9BACI/87-162 AC A0AAJ1WJV0.1
#=GS A0A918T0R3_9GAMM/12-88 AC A0A918T0R3.1
#=GS A0A498H1V3_9EURY/95-179 AC A0A498H1V3.1
#=GS A7HLY3_FERNB/45-127 AC A7HLY3.1
#=GS A0A1H1S3X0_9BACT/42-118 AC A0A1H1S3X0.1
#=GS D9SMB7_CLOC7/40-110 AC D9SMB7.1
#=GS A0A1B9AXS4_9BACI/52-130 AC A0A1B9AXS4.1
#=GS A0A4R8ZY90_9MICO/101-178 AC A0A4R8ZY90.1
#=GS A0A1Q9GKJ6_9GAMM/13-101 AC A0A1Q9GKJ6.1
#=GS A0A0Q7PVP0_9GAMM/18-91 AC A0A0Q7PVP0.1
#=GS A0A942RG04_UNCIG/40-129 AC A0A942RG04.1
#=GS G2QGG5_THET4/13-95 AC G2QGG5.1
#=GS A0A3M7TUR7_9BACI/32-90 AC A0A3M7TUR7.1
#=GS A0A143HR41_MICTH/33-127 AC A0A143HR41.1
#=GS A0A5C6M660_9PLAN/6-80 AC A0A5C6M660.1
#=GS M4V8C3_9BACT/18-100 AC M4V8C3.1
#=GS A0AAJ1T353_9BACI/45-123 AC A0AAJ1T353.1
#=GS A0A1I7GKW4_9BACT/40-128 AC A0A1I7GKW4.1
#=GS D0LSK8_HALO1/54-137 AC D0LSK8.1
#=GS A0A8J2VHQ5_9BACL/20-101 AC A0A8J2VHQ5.1
#=GS A0A975IZP0_9BACT/13-98 AC A0A975IZP0.1
#=GS A0A563ETM2_9PSEU/30-115 AC A0A563ETM2.1
#=GS A0A1N6Y2M8_9EURY/34-91 AC A0A1N6Y2M8.1
#=GS A0A9W4VLQ4_9GAMM/18-108 AC A0A9W4VLQ4.1
#=GS H6LD76_ACEWD/34-112 AC H6LD76.1
#=GS K4R000_STRDJ/92-172 AC K4R000.1
#=GS A0A5P9HT84_9BACI/57-134 AC A0A5P9HT84.1
#=GS A0A1R3WNQ7_9MICO/185-266 AC A0A1R3WNQ7.1
#=GS Q2IU68_RHOP2/131-216 AC Q2IU68.1
#=GS A0AAN0Y220_VIBNA/35-118 AC A0AAN0Y220.1
#=GS A0A231R171_9BACL/36-123 AC A0A231R171.1
#=GS W7T1A2_KUTS7/64-110 AC W7T1A2.1
#=GS A0A089JV19_9BACL/343-427 AC A0A089JV19.1
#=GS A0A4Q5NI76_UNCXX/32-110 AC A0A4Q5NI76.1
#=GS A0A934W9Z6_9BURK/136-201 AC A0A934W9Z6.1
#=GS A0A1I3RPC9_9BACL/77-149 AC A0A1I3RPC9.1
#=GS A0A926KJW6_9BACL/210-287 AC A0A926KJW6.1
#=GS A0A940FA54_9ACTN/23-96 AC A0A940FA54.1
#=GS A0A521EJQ4_9BACL/25-108 AC A0A521EJQ4.1
#=GS A0A0Q3SQ85_9BACI/56-132 AC A0A0Q3SQ85.1
#=GS A0A2V5JY03_9BACL/209-287 AC A0A2V5JY03.1
#=GS A0A848HNV0_9BURK/36-117 AC A0A848HNV0.1
#=GS A0A5S9ILA9_UABAM/25-96 AC A0A5S9ILA9.1
#=GS A0A6M0IPV7_9BACT/32-121 AC A0A6M0IPV7.1
#=GS H5WQJ7_9BURK/48-115 AC H5WQJ7.1
#=GS A0A6B8RGI5_9BACL/31-113 AC A0A6B8RGI5.1
#=GS A0A4Q7ZR39_9ACTN/17-78 AC A0A4Q7ZR39.1
#=GS W0DH51_9GAMM/37-116 AC W0DH51.1
#=GS A0A2T3MVM2_9GAMM/14-101 AC A0A2T3MVM2.1
#=GS A0A0J6D4A4_9BACI/25-98 AC A0A0J6D4A4.1
#=GS A0A2V2N7G9_9EURY/41-132 AC A0A2V2N7G9.1
#=GS A0A5K7ZDP5_9BACT/129-209 AC A0A5K7ZDP5.1
#=GS A0A926NIM2_9BACL/24-104 AC A0A926NIM2.1
#=GS A0A250VUY9_STROL/136-195 AC A0A250VUY9.1
#=GS A0A7C9I2C9_9DEIO/35-111 AC A0A7C9I2C9.1
#=GS A0A5K7Z4H9_9BACT/20-101 AC A0A5K7Z4H9.1
#=GS A0A2W0HTB0_9BACI/37-99 AC A0A2W0HTB0.1
#=GS A0A0P0CFW0_9BACT/38-126 AC A0A0P0CFW0.1
#=GS A0A0B7MGW7_9FIRM/33-108 AC A0A0B7MGW7.1
#=GS A0A0X8D1Q9_9BACL/68-146 AC A0A0X8D1Q9.1
#=GS A0A2T4ZAA7_9BACL/24-103 AC A0A2T4ZAA7.1
#=GS A0A0U3SLG0_9BACT/42-129 AC A0A0U3SLG0.1
#=GS A0A0Q0PF92_9GAMM/17-110 AC A0A0Q0PF92.1
#=GS A0A1W1VQ64_9BACT/41-130 AC A0A1W1VQ64.1
#=GS A0A081P919_9BACL/208-286 AC A0A081P919.1
#=GS A0A8U0IHN6_9EURY/37-94 AC A0A8U0IHN6.1
#=GS W9GP98_9PROT/26-107 AC W9GP98.1
#=GS A0A143H8L7_9BACL/54-129 AC A0A143H8L7.1
#=GS A0AA37WIT4_9ALTE/22-114 AC A0AA37WIT4.1
#=GS A0A0P6YN79_9CHLR/3-90 AC A0A0P6YN79.1
#=GS D3F637_CONWI/28-113 AC D3F637.1
#=GS A0A1H6X569_9DEIO/36-121 AC A0A1H6X569.1
#=GS A0A3Q9QQR4_9BACI/325-392 AC A0A3Q9QQR4.1
#=GS A0A931FU63_9BACT/38-127 AC A0A931FU63.1
#=GS A0A1Q8QWN3_9FIRM/39-111 AC A0A1Q8QWN3.1
#=GS A0A1Y6CG21_9BACT/21-96 AC A0A1Y6CG21.1
#=GS E1WXV6_HALMS/10-93 AC E1WXV6.1
#=GS A0A1H1F0Q9_9GAMM/32-116 AC A0A1H1F0Q9.1
#=GS A0A0J1FU92_9FIRM/82-159 AC A0A0J1FU92.1
#=GS A0A5K8AKL7_9BACT/128-210 AC A0A5K8AKL7.1
#=GS A0A6G7CR38_9VIBR/2-73 AC A0A6G7CR38.1
#=GS A0A2K8UF94_9GAMM/24-102 AC A0A2K8UF94.1
#=GS A0AA86T2H1_9BACT/41-122 AC A0AA86T2H1.1
#=GS A0A1V6M1X6_9BACT/25-101 AC A0A1V6M1X6.1
#=GS A0A221SWZ9_9DEIO/29-112 AC A0A221SWZ9.1
#=GS U5LEK8_9BACI/54-126 AC U5LEK8.1
#=GS M8EEK1_9BACL/66-143 AC M8EEK1.1
#=GS A0A1I0KPM0_9BACL/47-123 AC A0A1I0KPM0.1
#=GS Q39XN1_GEOMG/24-104 AC Q39XN1.1
#=GS A0A974ZP10_9GAMM/27-105 AC A0A974ZP10.1
#=GS A0A7X2J1D4_9BACI/55-128 AC A0A7X2J1D4.1
#=GS A0A1K1RDQ6_9BACL/52-127 AC A0A1K1RDQ6.1
#=GS A0A318SCM5_9DEIO/22-107 AC A0A318SCM5.1
#=GS A0A7J5TUS1_9BACT/32-121 AC A0A7J5TUS1.1
#=GS A0A0F5I7Q8_BACTR/37-117 AC A0A0F5I7Q8.1
#=GS A0A261QL55_9BACI/27-109 AC A0A261QL55.1
#=GS A0A1U9NI88_9BACT/20-100 AC A0A1U9NI88.1
#=GS A0A1S2RDF2_9BACI/30-110 AC A0A1S2RDF2.1
#=GS A0A4Y8LNK1_9BACL/62-144 AC A0A4Y8LNK1.1
#=GS A0A6M1RMS7_9BACT/136-214 AC A0A6M1RMS7.1
#=GS A0A398B1Q3_9BACI/35-115 AC A0A398B1Q3.1
#=GS A0A559KBX7_9BACL/209-286 AC A0A559KBX7.1
#=GS D5EQJ9_CORAD/3553-3633 AC D5EQJ9.1
#=GS A0A1I2K5V6_9GAMM/26-106 AC A0A1I2K5V6.1
#=GS A0A1I3UPW1_9BACL/86-163 AC A0A1I3UPW1.1
#=GS A0A0H5SEW4_HERHM/37-131 AC A0A0H5SEW4.1
#=GS A0A917B2L3_HALAA/33-113 AC A0A917B2L3.1
#=GS A0A2D0NHR8_FLAN2/84-166 AC A0A2D0NHR8.1
#=GS A0A263BX93_9BACI/27-95 AC A0A263BX93.1
#=GS A0A931HT18_9BACI/24-102 AC A0A931HT18.1
#=GS A0A6P1UAU5_9GAMM/21-101 AC A0A6P1UAU5.1
#=GS A0A2C1K3X2_9BACI/55-130 AC A0A2C1K3X2.1
#=GS A0A915UDL7_9BACT/36-121 AC A0A915UDL7.1
#=GS A0AA35CMR4_9FIRM/111-192 AC A0AA35CMR4.1
#=GS A0A330L2Y0_9BACT/57-139 AC A0A330L2Y0.1
#=GS A0AAU8Q6I8_DESK7/34-115 AC A0AAU8Q6I8.1
#=GS A0A1G8S6L9_9BACI/1-70 AC A0A1G8S6L9.1
#=GS A0A7S7NUL1_9BACT/24-98 AC A0A7S7NUL1.1
#=GS A0A318S4B8_9DEIO/29-100 AC A0A318S4B8.1
#=GS A0A1I5TG32_9BACT/48-122 AC A0A1I5TG32.1
#=GS Q2FU15_METHJ/37-123 AC Q2FU15.1
#=GS A0A2K9NSK8_BACTC/17-97 AC A0A2K9NSK8.1
#=GS A0A235F8X4_9BACI/39-121 AC A0A235F8X4.1
#=GS A0A7L9FHA2_9CREN/28-84 AC A0A7L9FHA2.1
#=GS A0A5S9IS36_UABAM/111-176 AC A0A5S9IS36.1
#=GS I8AG41_9BACI/57-121 AC I8AG41.1
#=GS C7R6T8_KANKD/28-100 AC C7R6T8.1
#=GS A0A2U3QDH9_9BACT/40-114 AC A0A2U3QDH9.1
#=GS V7I810_9CLOT/29-111 AC V7I810.1
#=GS A0A5M6D3P8_9BACT/42-118 AC A0A5M6D3P8.1
#=GS A0A1M5Q680_9BURK/33-95 AC A0A1M5Q680.1
#=GS A7HLX7_FERNB/53-129 AC A7HLX7.1
#=GS A0A4Y3JPU0_9ENTE/38-130 AC A0A4Y3JPU0.1
#=GS A0A1H8C7W7_STIAU/48-130 AC A0A1H8C7W7.1
#=GS A0A518GUC6_9BACT/31-117 AC A0A518GUC6.1
#=GS E8UBR3_DEIML/142-210 AC E8UBR3.1
#=GS A0A0C2DQ50_9BACT/24-103 AC A0A0C2DQ50.1
#=GS A0A919RM66_9ACTN/409-479 AC A0A919RM66.1
#=GS F0RMM4_DEIPM/41-120 AC F0RMM4.1
#=GS A0A221ST43_9DEIO/32-116 AC A0A221ST43.1
#=GS A0A7W2A8X3_9BACL/20-99 AC A0A7W2A8X3.1
#=GS A0JTS4_ARTS2/19-97 AC A0JTS4.1
#=GS A0A0Q6W0Q1_9BURK/22-102 AC A0A0Q6W0Q1.1
#=GS A0A6N9PYV5_9BACL/21-85 AC A0A6N9PYV5.1
#=GS A0A2T0K0L4_9ACTN/7-79 AC A0A2T0K0L4.1
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