#=GF ID Fn3-III_PB4
#=GF AC PF24171.3
#=GF DE Straight fiber protein PB4 third Fn3-like domain
#=GF AU Andreeva A;0000-0002-0450-0091
#=GF SE Manual
#=GF GA 27.70 27.70;
#=GF TC 27.70 155.40;
#=GF NC 27.40 19.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -E 1000 -Z 90746521 HMM pfamseq
#=GF TP Domain
#=GF CL CL0159
#=GF RN [1]
#=GF RM 36961893
#=GF RT Structural basis of bacteriophage T5 infection trigger and E.
#=GF RT coli cell wall perforation.
#=GF RA Linares R, Arnaud CA, Effantin G, Darnault C, Epalle NH, Boeri
#=GF RA Erba E, Schoehn G, Breyton C;
#=GF RL Sci Adv. 2023;9:eade9674.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents the third Fn3-like domain of the Straight
#=GF CC fiber protein PB4 found in T5-like phages. PB4 along with PB3,
#=GF CC forms the central straight fiber, bearing the receptor binding
#=GF CC protein PB5 at its C terminus [1]. Upon PB5 binding to the host
#=GF CC receptor FhuA, the central fiber reorganises and undergoes
#=GF CC structural rearrangements that lead to its bending, bringing PB3
#=GF CC close to the host membrane for anchoring [1]. The PB4-PB3
#=GF CC interactions are ensured by the proximal loops of the first and
#=GF CC the distal loops of the second of the three PB4 Fn3-like
#=GF CC domains. These interactions are disrupted upon binding to the
#=GF CC host receptor and the string of the three PB4 Fn3-like domains
#=GF CC undergoes drastic conformational changes.
#=GF SQ 33
#=GS A0A7S9SRL3_9CAUD/211-335 AC A0A7S9SRL3.1
#=GS A0A9E7E6Q1_9CAUD/199-323 AC A0A9E7E6Q1.1
#=GS A0A0A7RSN8_9CAUD/211-335 AC A0A0A7RSN8.1
#=GS A0AAE7XZI8_9CAUD/206-334 AC A0AAE7XZI8.1
#=GS A0AAE9YN11_9CAUD/211-335 AC A0AAE9YN11.1
#=GS A0A2Z5HTA7_9CAUD/211-335 AC A0A2Z5HTA7.1
#=GS A0A5Q2U9W3_9CAUD/211-335 AC A0A5Q2U9W3.1
#=GS A0A4Y6E9K5_9CAUD/205-329 AC A0A4Y6E9K5.1
#=GS A0A193H0Y1_9CAUD/211-335 AC A0A193H0Y1.1
#=GS A0A2H4PHG8_9CAUD/211-335 AC A0A2H4PHG8.1
#=GS A0AAE9CF73_9CAUD/211-335 AC A0AAE9CF73.1
#=GS A0A0N9BA91_9CAUD/205-329 AC A0A0N9BA91.1
#=GS A0A1S6KUW3_9CAUD/208-332 AC A0A1S6KUW3.1
#=GS A0AA50F3X8_9CAUD/211-335 AC A0AA50F3X8.1
#=GS A0AAE7V7D0_9CAUD/189-313 AC A0AAE7V7D0.1
#=GS A0A4Y5P1C3_9CAUD/216-340 AC A0A4Y5P1C3.1
#=GS FIBC_BPT5/211-335 AC Q6QGF0.1
#=GS A0A6M3H7Q3_9CAUD/211-335 AC A0A6M3H7Q3.1
#=GS B2I4I6_9CAUD/93-217 AC B2I4I6.1
#=GS A0AA51R796_9CAUD/196-320 AC A0AA51R796.1
#=GS I7KQX9_9CAUD/211-335 AC I7KQX9.1
#=GS A0A385E4P2_9CAUD/206-334 AC A0A385E4P2.1
#=GS A0A0B5H906_9CAUD/206-327 AC A0A0B5H906.1
#=GS A0A7L5CE38_9CAUD/211-335 AC A0A7L5CE38.1
#=GS A0A2D2W790_9CAUD/210-334 AC A0A2D2W790.1
#=GS A0A7S9SS90_9CAUD/211-335 AC A0A7S9SS90.1
#=GS J9QL18_9CAUD/210-334 AC J9QL18.1
#=GS A0A2H4PRG2_9CAUD/207-331 AC A0A2H4PRG2.1
#=GS A0A162EA37_9CAUD/216-340 AC A0A162EA37.1
#=GS A0A2H5BGC9_9CAUD/205-329 AC A0A2H5BGC9.1
#=GS A0AAE7VZB4_9CAUD/216-340 AC A0AAE7VZB4.1
#=GS A0A679DL43_9CAUD/205-329 AC A0A679DL43.1
#=GS H6WXP7_9CAUD/205-329 AC H6WXP7.1
A0A7S9SRL3_9CAUD/211-335 .PPAAPINIVFKAARIADGKERYDLRVQWDWNRGTGSNVREFVLSYIDSAEF....ARTGWTKAQKINVGAAQSATIISFPWKVEHKFKVSSIAWGPDAQDVTDSAVQTFILNESTPLDNSFVNETGIEV
A0A9E7E6Q1_9CAUD/199-323 .PPSKPDRLVFKAARIADGKERYDVRLEWNWEKGAGAYAREFVVWYIDQESF....ATSGWANAQKINAGAAKAVTITTFPWNRTMRFKVQAVAWGPDTQAVVDSSETTYILNESTPLDDSFVNETGIEV
A0A0A7RSN8_9CAUD/211-335 .PPTAPTNIAFKAARIADGKERYDARIEWDWERGAGANVREFLVTYINSEEY....ARTGWAKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNRQDITESAPATFILNEDTPLDNSFVNETGIDV
A0AAE7XZI8_9CAUD/206-334 .PPSAPTNITFTTAKLAEPAERFDVLVAWDWDRGTGPDIREFVLYSIPTSLYdsnpANDKWRDATRVNTGVAQSYVHIGHPFELPMKYMVASIAWGPTEENTAFSNIVDFEITTSTPIDNDFTTQTGVEV
A0AAE9YN11_9CAUD/211-335 .PPTAPINIKFKAARIADGKERYDVRIEWEWLKGNGSNVREFLVTYIDSAEY....ARTGWAKAQKINVGAAQAATIVSFPWKVGHTFKVASIAWGPDKQDITESAPVTFILNEDTPLDNSFVNETGIEV
A0A2Z5HTA7_9CAUD/211-335 .PPTAPTNIHFKAARIADGKERYDVRIEWDWLKGGGSNVREFLVTYIDSAEF....ARTGWTKAQKINVGAAQAATIVSFPWKVDHTFKVASIAWGPDKQDITESAPVTFILNEDTPLDNSFVNETGIEV
A0A5Q2U9W3_9CAUD/211-335 .PPSAPTNLRFRTARIQDGMERFDVRLEWDWVRGSGANVREFVVYWIDDTEF....AKTGWTKAQVMNVGAAKAATIMSFPWKIGHKFRVSAVAWGPATQDISYSANASHIINESTVFDNSFANETGIDV
A0A4Y6E9K5_9CAUD/205-329 .PPSAPNNVSFKVAKIMDGMERYDLQVAWDWNKGTGSSVREFVLYFVETSEY....NKTRWEKASKVNSGAAQASVITSFPFNKEYKFKVASVAWGPDDQAIVDSSIATFKIDKNTPIDSSFTNNTGIEV
A0A193H0Y1_9CAUD/211-335 .PPTAPTNIAFKAARIADGKERYDVRIEWDWERGAGANVREFLVTYINSEEY....AKTGWTKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNKQDITESAPVTFILNEDTPLDNSFVNETGIDV
A0A2H4PHG8_9CAUD/211-335 s-PTAPVNIVFKAARIADGKERYDLRVQWDWNRGTGANVREFVLSYIDSTEF....AKTGWTKAQKINVGAAQSATIISFPWKVEHKFKVSSIAWGPNIQDTTDSTAQTFILNEDTPLDNNFVNETGIEV
A0AAE9CF73_9CAUD/211-335 .PPTAPSNITFKAARIADGKERYDLRVQWDWNRGSGANVREFVVSYIDSAEF....ARTGWTKAQKINVGAAQAATIISFPWKIEHKFKVSSIAWGPDAKDVTDSAVQTFILNEDTPLDNSFVNETGIEV
A0A0N9BA91_9CAUD/205-329 .PPSAPENIDFKVAKIMDGIERYDLQVSWDWNKGTGSSVREFVLYFVESSEY....NKTQWSKASKINSGAAKAAVITSFPFNKEYKFKIAAIAWGPADQALTDSVGASFKITNNTPLDSSFTNETGIEV
A0A1S6KUW3_9CAUD/208-332 .PPSKPTNLTFTAARILDGNERYDVQVKWNWSAGSGANIREFVMYYVSKAEF....DKTGWAKAARVNTGATQAAIITGFPWEIPTVFKVEAISWGPSDKNTTASDNANFTLNASIPLDSSFTKTTGIEI
A0AA50F3X8_9CAUD/211-335 .PPTAPIDIVFKAARIADGKERYDVRIEWDWERGAGANVREFLVTYINSEEY....AKTGWAKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNKQDITESAPVTFILNEDTPLDNSFVNETGIDV
A0AAE7V7D0_9CAUD/189-313 .PPTAPINIVFKAARIADGKERYDVRIEWDWERGAGANVREFLVTYINSEEY....AKTGWAKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNKQDITESAPVTYILEDNTPLDNSFVNETGIDV
A0A4Y5P1C3_9CAUD/216-340 .PPSAATNLQFKVAHVLDGKERYDLRVEWDWEKGDGANLREFALSYIDSATY....AASGWTKAQVMNVSSSKKATIPSFPFKVGHKFKVTSTAWGPDDKDATDSIIADFIIDENTPIDNSFINETGIDM
FIBC_BPT5/211-335 .PPAAPINIVFKAARIADGKERYDLRVQWDWNRGAGANVREFVLSYIDSAEF....VRTGWTKAQKINVGAAQSATIISFPWKVEHKFKVSSIAWGPDAQDVTDSAVQTFILNESTPLDNSFVNETGIEV
A0A6M3H7Q3_9CAUD/211-335 .PPTAPIDIVFKAARIADGKERYDVRIEWDWERGAGANVREFLVTYINSEEY....AKTGWAKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNKQDITESAPVTFILNEDTPLDNSFVNETGIDV
B2I4I6_9CAUD/93-217 .PPTAPIDIVFKAARIADGKERYDVRIEWEWERGAGANVREFLVTYINSEEY....AKTGWAKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNKQDITESAPVTFILNEDTPLDNSFVNETGIDV
A0AA51R796_9CAUD/196-320 .PPTAPIDIVFKAARIADGKERYDVRIEWDWERGAGANVREFLVTYINSEEY....AKTGWAKAQKINVGAARAATIISFPWRVEHTFKVSSIAWGPNKQDITESAPVTFILNEDTPLDNSFVNETGIDV
I7KQX9_9CAUD/211-335 .PPTAPSDITFKAARIADGKERYDVRVEWDWERGNGSNVREFLVTYIDSAEY....ARTGWSKAQKINVGAAKAATIVSFPWKVEHTFKVSSIAWGPNEQSITESAPSTLILDEDTVLDNSFINETGIEL
A0A385E4P2_9CAUD/206-334 .PPEKVSNVTFQVAKLKEPAERYDVKISWDWEKLDGANAREFVVWRLDKAKYdsnsASDKWAGAEVINAGTAKSVVVTNHPFDREQVYRVATTAWGPESDDVVYADNIIFKIDDTTTIDNSFTNETGIDL
A0A0B5H906_9CAUD/206-327 .PPSKPGTPTFKVFKIKDGVERYDLKVSWSFTQGSGSYAKEFVLQFMDA---....SLTDWSRAAVINSGTATSATISSFAFNKAFKFRVTAYSWGPAASNFTVSDQATFTLTSSTPVDTESAVDTNIEV
A0A7L5CE38_9CAUD/211-335 .PPTAPVNIAFKAARIADGKERYDLRVQWDWNRGAGANVREFVVSYIDSAEF....ARTGWTKAQKINVGAAQAATIISFPWKVEHKFKVSSIAWGPDAQDVTDSMVQTFILNESTPLDNSFVNETGIEV
A0A2D2W790_9CAUD/210-334 .PPTAPKNMRFRVARIQDGKERYDLRVEWDWEKETGANVREFSLHYIESSEY....AATGWSKAQVINVGAARAATITSFPLSRTYRFKVSSIAWGPDTQAVTESDPVEFILTPDTPLDSSFTNETGIEV
A0A7S9SS90_9CAUD/211-335 .PPTAPIDIVFKAARIADGKERYDVRIEWDWERGAGANVREFLVTYINSEEY....AKTGWAKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNKQDITESAPVTFILNEDTPLDNSFVNETGIDV
J9QL18_9CAUD/210-334 .PPSAPKNIQFKAARIQDGKERYDVRVEWDWEKDIGANVREFSLHYVEFDEF....AVSGWEKAQVINVGAARAATITSFPFNRRYKFKVSSIAWGPDTQAITEAPSVEYILTEDTILDSSFTNETGIEV
A0A2H4PRG2_9CAUD/207-331 .PPTAPSNLGFVAAQIKDGVTRYDVKLTWDWNRGSGPAIRDFVVYYVTKTEY....DKTKWSTASVINTGATQQAVLVNFPWGVPSVFKVVATTWGTAGSNITESSVANFTLNDSTKIDNTFANETGIDI
A0A162EA37_9CAUD/216-340 .PPTAPIDIVFKAARIADGKERYDVRIEWDWERGTGANVREFLVTYINSEEY....AKTGWAKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNKQDITESVPVTFILNEDTPLDNSFVNETGIDV
A0A2H5BGC9_9CAUD/205-329 .PPSAPTNVSFKVAKIMDGMERYDLQVAWDWNKGTGSSVREFVLYFVETSEY....NKTRWEKASKINSGAAQASVITGFPFNKEYKFKVASVAWGPDDQAIVDSSVATFKIDKNTPIDSSFTNNTGIEV
A0AAE7VZB4_9CAUD/216-340 .PPTAPTNIAFKAARIADGKERYDVRIEWDWERGAGANVREFLVTYINSEEY....AKTGWAKAQKINVGAARAATIISFPWKVEHTFKVSSIAWGPNKQDITESAPVTFILNEDTPLDNSFVNETGIDV
A0A679DL43_9CAUD/205-329 .PPSAPENMNFKVAKIMDGIERYDLQVSWDWDKGTGSSVREFVLYFVESSEY....NKTQWKKASKINSGAAKASVITGFPFNKEYKFKVAAIAWGPADQALTDSITSSFKITSQTTIDSSFANDTGIEV
H6WXP7_9CAUD/205-329 .PPSAPENINFKVAKIMDGIERYDLQVSWDWDKGTGSSVREFVLYFVETSEY....NKTQWRKASKINSGAAKASVITSFPFNKEYKFKVAAIAWGPADQALTDSNTAAFKITSSTPLDSSFANETGIEV
#=GC seq_cons .PPoAPpNIsFKAARIADGKERYDlRlpWDWp+GsGANVREFllpYI-SsEY....A+TGWsKAQKINVGAA+AATIlSFPW+lEHpFKVoSIAWGPscQDlT-SussTFILNEsTPLDNSFlNETGI-V
//
