GenomeNet

Database: Pfam
Entry: Foie-gras_1
LinkDB: Foie-gras_1
Original site: Foie-gras_1 
#=GF ID   Foie-gras_1
#=GF AC   PF11817.10
#=GF DE   Foie gras liver health family 1
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Pfam-B_4417 (release 23.0)
#=GF GA   23.30 23.30;
#=GF TC   23.30 23.30;
#=GF NC   23.20 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Repeat
#=GF CL   CL0020
#=GF RN   [1]
#=GF RM   16000385
#=GF RT   A genetic screen in zebrafish identifies the mutants vps18, nf2
#=GF RT   and foie gras as models of liver disease. 
#=GF RA   Sadler KC, Amsterdam A, Soroka C, Boyer J, Hopkins N; 
#=GF RL   Development. 2005;132:3561-3572.
#=GF DR   INTERPRO; IPR021773;
#=GF DR   SO; 0001068; polypeptide_repeat;
#=GF CC   Mutating the gene foie gras in zebrafish has been shown to
#=GF CC   affect development; the mutants develop large, lipid-filled
#=GF CC   hepatocytes in the liver, resembling those in individuals with
#=GF CC   fatty liver disease [1]. Foie-gras protein is long and has
#=GF CC   several well-defined domains though none of them has a known
#=GF CC   function. We have annotated this one as the first [1]. The
#=GF CC   C-terminus of this region contains TPR repeats.
#=GF SQ   1988
#=GS A0A0L1ILJ2_ASPNO/257-351    AC A0A0L1ILJ2.1
#=GS A0A0C9YMM8_9AGAR/334-603    AC A0A0C9YMM8.1
#=GS A0A314ZEI5_PRUYE/248-514    AC A0A314ZEI5.1
#=GS A0A3Q3E152_9LABR/263-520    AC A0A3Q3E152.1
#=GS A0A1V6ST72_9EURO/260-355    AC A0A1V6ST72.1
#=GS A0A0V1MQV0_9BILA/266-514    AC A0A0V1MQV0.1
#=GS A0A1S3ZP80_TOBAC/39-308     AC A0A1S3ZP80.1
#=GS A0A087XVG8_POEFO/263-520    AC A0A087XVG8.2
#=GS A0A1V6RXL6_9EURO/360-635    AC A0A1V6RXL6.1
#=GS A0A1D6HI71_MAIZE/13-283     AC A0A1D6HI71.1
#=GS A0A4Z1JFS6_9HELO/246-326    AC A0A4Z1JFS6.1
#=GS A0A1V8UIB7_9PEZI/346-627    AC A0A1V8UIB7.1
#=GS A0A443RAL7_9ACAR/378-539    AC A0A443RAL7.1
#=GS C7YM27_NECH7/338-606        AC C7YM27.1
#=GS A0A250X1F6_9CHLO/567-647    AC A0A250X1F6.1
#=GS A0A1U7YW92_NICSY/254-523    AC A0A1U7YW92.1
#=GS A0A135LRN2_PENPA/359-634    AC A0A135LRN2.1
#=GS A0A2C6AE04_9HYPO/330-598    AC A0A2C6AE04.1
#=GS A0A150V1G4_9PEZI/350-632    AC A0A150V1G4.1
#=GS A0A0J8QM48_COCIT/229-349    AC A0A0J8QM48.1
#=GS W6MTD0_9ASCO/364-610        AC W6MTD0.1
#=GS A0A444WWA3_ARAHY/258-527    AC A0A444WWA3.1
#=GS A0A4V5N7N3_9PEZI/247-328    AC A0A4V5N7N3.1
#=GS A0A1U7S8N2_ALLSI/398-557    AC A0A1U7S8N2.2
#=GS M7U6C1_BOTF1/246-330        AC M7U6C1.1
#=GS A0A1D3D9L7_9EIME/510-671    AC A0A1D3D9L7.1
#=GS V5G1J1_BYSSN/335-614        AC V5G1J1.1
#=GS A0A287UKX3_HORVV/113-382    AC A0A287UKX3.1
#=GS A0A3M6UYM8_9CNID/1-93       AC A0A3M6UYM8.1
#=GS A0A3Q1AN27_AMPOC/265-522    AC A0A3Q1AN27.1
#=GS Q2UPL2_ASPOR/356-635        AC Q2UPL2.1
#=GS A0A453PEP9_AEGTS/1-136      AC A0A453PEP9.1
#=GS A0A423WXV9_9PEZI/341-609    AC A0A423WXV9.1
#=GS A0A5E4QGU9_9NEOP/362-617    AC A0A5E4QGU9.1
#=GS A0A3G2S2P4_9BASI/338-413    AC A0A3G2S2P4.1
#=GS A0A5C7HQB1_9ROSI/256-524    AC A0A5C7HQB1.1
#=GS A0A166RPV2_9AGAM/487-601    AC A0A166RPV2.1
#=GS A0A0V0RKT5_9BILA/324-572    AC A0A0V0RKT5.1
#=GS A0A3N0YX58_ANAGA/263-522    AC A0A3N0YX58.1
#=GS A0A093FZ87_DRYPU/263-522    AC A0A093FZ87.1
#=GS A0A6I8SEV7_XENTR/263-522    AC A0A6I8SEV7.1
#=GS U3DLX8_CALJA/263-522        AC U3DLX8.1
#=GS A0A1Y2UBG1_9PEZI/337-604    AC A0A1Y2UBG1.1
#=GS A0A2T3AY12_AMORE/340-610    AC A0A2T3AY12.1
#=GS A0A397Y8K3_BRACM/294-564    AC A0A397Y8K3.1
#=GS G1KUF4_ANOCA/441-588        AC G1KUF4.2
#=GS A0A1D6HI69_MAIZE/256-526    AC A0A1D6HI69.1
#=GS A0A1Y1I9V9_KLENI/3-182      AC A0A1Y1I9V9.1
#=GS A0A2J6SC44_9HELO/335-603    AC A0A2J6SC44.1
#=GS M0T155_MUSAM/236-508        AC M0T155.1
#=GS A0A507AZG4_9PEZI/333-601    AC A0A507AZG4.1
#=GS R7YHS6_CONA1/254-334        AC R7YHS6.1
#=GS A0A0D3F9N5_9ORYZ/256-526    AC A0A0D3F9N5.1
#=GS M4BD49_HYAAE/278-554        AC M4BD49.1
#=GS A0A2U4A7T3_TURTR/263-522    AC A0A2U4A7T3.2
#=GS A0A2R6WLJ3_MARPO/255-530    AC A0A2R6WLJ3.1
#=GS A0A2Z6SJP1_9GLOM/390-660    AC A0A2Z6SJP1.1
#=GS H3B9W2_LATCH/383-546        AC H3B9W2.2
#=GS A0A2V5H5J0_9EURO/259-352    AC A0A2V5H5J0.1
#=GS A0A5N6NEY5_9ASTR/90-378     AC A0A5N6NEY5.1
#=GS A0A4U5UFA2_COLLU/263-520    AC A0A4U5UFA2.1
#=GS A0A2G5B592_COERN/873-951    AC A0A2G5B592.1
#=GS A0A178E3U5_9PLEO/353-636    AC A0A178E3U5.1
#=GS W9S569_9ROSA/3-178          AC W9S569.1
#=GS A0A0V1D210_TRIBR/331-579    AC A0A0V1D210.1
#=GS A0A663ER88_AQUCH/263-522    AC A0A663ER88.1
#=GS A0A2G5C2Z7_AQUCA/238-513    AC A0A2G5C2Z7.1
#=GS F6I0C3_VITVI/251-521        AC F6I0C3.1
#=GS A0A024TBS8_9STRA/271-531    AC A0A024TBS8.1
#=GS K1XTU1_MARBU/244-321        AC K1XTU1.1
#=GS A0A1W4XIB8_AGRPL/270-527    AC A0A1W4XIB8.1
#=GS A0A2N6NCK9_BEABA/339-603    AC A0A2N6NCK9.1
#=GS A0A6A4G4L7_9STRA/278-554    AC A0A6A4G4L7.1
#=GS A0A395GY36_9EURO/357-636    AC A0A395GY36.1
#=GS M2UCQ8_COCH5/350-634        AC M2UCQ8.1
#=GS A0A4W2CGK3_BOBOX/263-522    AC A0A4W2CGK3.1
#=GS A0A6J3QR07_TURTR/177-436    AC A0A6J3QR07.1
#=GS A0A5M9JG38_MONFR/342-610    AC A0A5M9JG38.1
#=GS A0A446WJ28_TRITD/113-382    AC A0A446WJ28.1
#=GS A0A4W6E5F3_LATCA/263-520    AC A0A4W6E5F3.1
#=GS A0A0C2GGY8_9BILA/2-116      AC A0A0C2GGY8.1
#=GS D2V5R7_NAEGR/353-630        AC D2V5R7.1
#=GS A0A2I4EH98_JUGRE/288-558    AC A0A2I4EH98.2
#=GS G7XKR2_ASPKW/356-635        AC G7XKR2.1
#=GS A0A671V7F7_SPAAU/263-520    AC A0A671V7F7.1
#=GS A0A2I0S8X7_9PEZI/344-623    AC A0A2I0S8X7.1
#=GS A0A2T0FEF8_9ASCO/362-508    AC A0A2T0FEF8.1
#=GS A0A1Q5Q8D5_9EURO/343-621    AC A0A1Q5Q8D5.1
#=GS E1BL02_BOVIN/394-531        AC E1BL02.2
#=GS R0F0E5_9BRAS/270-541        AC R0F0E5.1
#=GS A0A218VFS2_9PASE/264-523    AC A0A218VFS2.1
#=GS A0A067G7S3_CITSI/264-534    AC A0A067G7S3.1
#=GS A0A2K6E1T8_MACNE/263-522    AC A0A2K6E1T8.1
#=GS A0A4W3IXB5_CALMI/263-521    AC A0A4W3IXB5.1
#=GS A0A4Q4V973_9PEZI/337-605    AC A0A4Q4V973.1
#=GS A0A2Y9QFZ9_TRIMA/263-522    AC A0A2Y9QFZ9.1
#=GS A0A674BKZ4_SALTR/263-510    AC A0A674BKZ4.1
#=GS D0MTU0_PHYIT/278-554        AC D0MTU0.1
#=GS A0A0H1B744_9EURO/223-346    AC A0A0H1B744.1
#=GS A0A177D017_9PLEO/352-636    AC A0A177D017.1
#=GS A0A493T2L8_ANAPP/263-522    AC A0A493T2L8.1
#=GS I3K0E1_ORENI/263-523        AC I3K0E1.2
#=GS A0A6G0HGM4_LARCR/263-520    AC A0A6G0HGM4.1
#=GS A0A1V4JBY3_PATFA/390-556    AC A0A1V4JBY3.1
#=GS B8M738_TALSN/340-618        AC B8M738.1
#=GS A0A395RPT2_FUSSP/338-587    AC A0A395RPT2.1
#=GS A0A2P4ZWD7_9HYPO/335-603    AC A0A2P4ZWD7.1
#=GS W5N8E9_LEPOC/263-522        AC W5N8E9.1
#=GS A0A329RR96_9STRA/278-552    AC A0A329RR96.1
#=GS A0A2V0NU71_9CHLO/268-523    AC A0A2V0NU71.1
#=GS C6HQ37_AJECH/322-445        AC C6HQ37.1
#=GS A0A2G3C366_CAPCH/517-646    AC A0A2G3C366.1
#=GS A0A1M8A536_MALS4/429-535    AC A0A1M8A536.1
#=GS A0A453JZS4_AEGTS/166-267    AC A0A453JZS4.1
#=GS A0A131MBH5_CAEEL/1-243      AC A0A131MBH5.1
#=GS M1WIS4_CLAP2/322-589        AC M1WIS4.1
#=GS A0A0B0N1N2_GOSAR/249-520    AC A0A0B0N1N2.1
#=GS A0A166PJM8_9EURO/246-339    AC A0A166PJM8.1
#=GS A0A1D2NET0_ORCCI/385-611    AC A0A1D2NET0.1
#=GS A0A088AVL1_APIME/263-520    AC A0A088AVL1.1
#=GS A0A0V0RKF1_9BILA/324-572    AC A0A0V0RKF1.1
#=GS A0A1E3QYE9_9ASCO/345-430    AC A0A1E3QYE9.1
#=GS A0A1L9UQR5_ASPBC/256-351    AC A0A1L9UQR5.1
#=GS A0A0M0JGS2_9EUKA/269-555    AC A0A0M0JGS2.1
#=GS A0A074YPD1_AURSE/351-632    AC A0A074YPD1.1
#=GS A0A1C7LZ70_GRIFR/369-535    AC A0A1C7LZ70.1
#=GS A0A2N5VP93_9BASI/349-604    AC A0A2N5VP93.1
#=GS W5J8F1_ANODA/262-515        AC W5J8F1.1
#=GS W3WMF8_PESFW/337-606        AC W3WMF8.1
#=GS N1Q7H2_PSEFD/344-624        AC N1Q7H2.1
#=GS A0A556VA94_BAGYA/260-519    AC A0A556VA94.1
#=GS A0A1W0WWJ0_HYPDU/289-531    AC A0A1W0WWJ0.1
#=GS I2FN08_USTH4/382-654        AC I2FN08.1
#=GS A0A3M7PK91_BRAPC/259-522    AC A0A3M7PK91.1
#=GS A0A6I8WCU3_DROPS/265-519    AC A0A6I8WCU3.1
#=GS A0A662WXZ9_9STRA/278-554    AC A0A662WXZ9.1
#=GS A0A0H1B744_9EURO/347-626    AC A0A0H1B744.1
#=GS A0A0C9TZ17_PAXIN/351-615    AC A0A0C9TZ17.1
#=GS B6QQY0_TALMQ/245-336        AC B6QQY0.1
#=GS A0A665VH02_ECHNA/263-520    AC A0A665VH02.1
#=GS A0A0D7A621_9AGAR/336-597    AC A0A0D7A621.1
#=GS A0A2J7R7T4_9NEOP/199-456    AC A0A2J7R7T4.1
#=GS A0A0F8UAG5_9EURO/257-352    AC A0A0F8UAG5.1
#=GS A0A0U1LQH6_TALIS/343-621    AC A0A0U1LQH6.1
#=GS A0A444EBU6_ENSVE/2-90       AC A0A444EBU6.1
#=GS A0A2K3CQW7_CHLRE/514-708    AC A0A2K3CQW7.1
#=GS A0A0V0VHN2_9BILA/326-574    AC A0A0V0VHN2.1
#=GS R0M1D6_ANAPL/289-453        AC R0M1D6.1
#=GS A0A2S6C0Z2_9PEZI/344-622    AC A0A2S6C0Z2.1
#=GS A0A0P7WR51_SCLFO/255-295    AC A0A0P7WR51.1
#=GS V4UGJ6_9ROSI/264-424        AC V4UGJ6.1
#=GS A0A194RMK7_PAPMA/329-555    AC A0A194RMK7.1
#=GS A0A2B7Y2X2_9EURO/360-639    AC A0A2B7Y2X2.1
#=GS I0YJS8_COCSC/273-530        AC I0YJS8.1
#=GS A0A3Q1AXH6_AMPOC/263-523    AC A0A3Q1AXH6.1
#=GS A0A0B7G0X8_THACB/362-653    AC A0A0B7G0X8.1
#=GS A0A059JA99_TRIIM/245-329    AC A0A059JA99.1
#=GS A0A1J8QGJ0_9AGAM/355-611    AC A0A1J8QGJ0.1
#=GS M2UCQ8_COCH5/249-340        AC M2UCQ8.1
#=GS A0A504YQW1_FASGI/273-403    AC A0A504YQW1.1
#=GS A0A395HN93_ASPHC/357-636    AC A0A395HN93.1
#=GS A0A6A5MKL6_LUPAL/282-550    AC A0A6A5MKL6.1
#=GS A0A5A7QZ66_STRAF/328-597    AC A0A5A7QZ66.1
#=GS A0A672Z344_9TELE/275-524    AC A0A672Z344.1
#=GS A0A1F5L3V2_9EURO/254-353    AC A0A1F5L3V2.1
#=GS A0A0N4TPD2_BRUPA/341-617    AC A0A0N4TPD2.1
#=GS M7B7G8_CHEMY/358-533        AC M7B7G8.1
#=GS A0A3B6NSU9_WHEAT/256-525    AC A0A3B6NSU9.1
#=GS A0A397HSP2_9EURO/358-637    AC A0A397HSP2.1
#=GS A0A200PQN6_9MAGN/537-656    AC A0A200PQN6.1
#=GS E3QU68_COLGM/337-605        AC E3QU68.1
#=GS A0A317WBJ8_9EURO/255-352    AC A0A317WBJ8.1
#=GS A0A369RSX8_9METZ/410-556    AC A0A369RSX8.1
#=GS B0X9L5_CULQU/269-520        AC B0X9L5.1
#=GS A0A1F7ZXI5_9EURO/257-351    AC A0A1F7ZXI5.1
#=GS A0A2H3H4C0_FUSOX/338-606    AC A0A2H3H4C0.1
#=GS A0A2P5B7T6_PARAD/242-512    AC A0A2P5B7T6.1
#=GS A0A0A2KL93_PENIT/360-635    AC A0A0A2KL93.1
#=GS A0A667WMT2_9TELE/263-524    AC A0A667WMT2.1
#=GS A0A0L0C850_LUCCU/428-547    AC A0A0L0C850.1
#=GS A0A2Y9N0E1_DELLE/263-522    AC A0A2Y9N0E1.1
#=GS C1GPA7_PARBA/260-355        AC C1GPA7.2
#=GS W5PBK1_SHEEP/264-523        AC W5PBK1.1
#=GS A1D3G8_NEOFI/358-637        AC A1D3G8.1
#=GS A0A4W4FSZ5_ELEEL/263-522    AC A0A4W4FSZ5.1
#=GS B9T2L8_RICCO/253-523        AC B9T2L8.1
#=GS A0A672Z326_9TELE/275-532    AC A0A672Z326.1
#=GS A0A3Q0KNU9_SCHMA/449-617    AC A0A3Q0KNU9.1
#=GS A0A4R8RML2_COLTR/337-605    AC A0A4R8RML2.1
#=GS C4R207_KOMPG/319-560        AC C4R207.1
#=GS V8NII9_OPHHA/305-456        AC V8NII9.1
#=GS W6UFW1_ECHGR/283-595        AC W6UFW1.1
#=GS A0A2R6X7U4_MARPO/574-694    AC A0A2R6X7U4.1
#=GS Q6CF42_YARLI/409-653        AC Q6CF42.1
#=GS A0A444THN7_ARMVU/227-414    AC A0A444THN7.1
#=GS G1P7X9_MYOLU/264-523        AC G1P7X9.1
#=GS A0A5B0PXA0_PUCGR/353-613    AC A0A5B0PXA0.1
#=GS A0A430QC30_SCHBO/326-507    AC A0A430QC30.1
#=GS A0A094L465_ANTCR/196-455    AC A0A094L465.1
#=GS A0A1U8B496_NELNU/253-524    AC A0A1U8B496.1
#=GS G5CAK9_HETGA/263-522        AC G5CAK9.1
#=GS L1JMA9_GUITC/211-445        AC L1JMA9.1
#=GS A0A4Y7PMA0_9AGAM/379-648    AC A0A4Y7PMA0.1
#=GS A0A5A7RD61_STRAF/608-707    AC A0A5A7RD61.1
#=GS A0A445J3G1_GLYSO/113-383    AC A0A445J3G1.1
#=GS A0A1U8HJT9_GOSHI/222-410    AC A0A1U8HJT9.1
#=GS A0A439CXI6_9PEZI/333-481    AC A0A439CXI6.1
#=GS A0A1Y1ZTA1_9PLEO/253-335    AC A0A1Y1ZTA1.1
#=GS A0A251NDH2_PRUPE/236-504    AC A0A251NDH2.1
#=GS A0A0E1RX69_COCIM/353-633    AC A0A0E1RX69.1
#=GS A0A1J9QEJ7_9EURO/234-357    AC A0A1J9QEJ7.1
#=GS A0A674BJX7_SALTR/263-505    AC A0A674BJX7.1
#=GS A0A3Q3XBC7_MOLML/263-520    AC A0A3Q3XBC7.1
#=GS A0A3P9A0D4_ESOLU/263-522    AC A0A3P9A0D4.2
#=GS A0A2K3LJZ9_TRIPR/113-213    AC A0A2K3LJZ9.1
#=GS A0A1S8VPV0_9FUNG/146-458    AC A0A1S8VPV0.1
#=GS B7P2U2_IXOSC/264-527        AC B7P2U2.1
#=GS A0A1U7YFY7_NICSY/39-308     AC A0A1U7YFY7.1
#=GS A0A1V6SKS7_9EURO/360-635    AC A0A1V6SKS7.1
#=GS A0A319DVF7_ASPSB/357-636    AC A0A319DVF7.1
#=GS A0A1Y2WZ05_9PEZI/337-604    AC A0A1Y2WZ05.1
#=GS A0A0P0VNW9_ORYSJ/1-77       AC A0A0P0VNW9.1
#=GS A0A1U7LUP2_NEOID/354-456    AC A0A1U7LUP2.1
#=GS A0A452ICE4_9SAUR/254-508    AC A0A452ICE4.1
#=GS A0A284QNA4_ARMOS/479-597    AC A0A284QNA4.1
#=GS A0A2I1FZH1_9GLOM/417-687    AC A0A2I1FZH1.1
#=GS G4NCT1_MAGO7/333-603        AC G4NCT1.1
#=GS A0A1D6FHN9_MAIZE/29-246     AC A0A1D6FHN9.1
#=GS A0A166ACY6_9AGAM/469-587    AC A0A166ACY6.1
#=GS F7GY05_MACMU/263-522        AC F7GY05.3
#=GS L8HHK5_ACACA/313-582        AC L8HHK5.1
#=GS A0A5J5EIF3_9PEZI/389-651    AC A0A5J5EIF3.1
#=GS A0A4P9Z2C3_9FUNG/514-772    AC A0A4P9Z2C3.1
#=GS A0A1L9UQR5_ASPBC/356-635    AC A0A1L9UQR5.1
#=GS A0A091LL84_CATAU/65-324     AC A0A091LL84.1
#=GS G4TBI1_SERID/306-562        AC G4TBI1.1
#=GS A0A2R9A614_PANPA/263-522    AC A0A2R9A614.1
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