#=GF ID   FrvR_3rd
#=GF AC   PF30457.1
#=GF DE   Frv operon regulatory protein FrvR, third domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   TED:P32152_TED03
#=GF GA   27.00 27.00;
#=GF TC   27.20 29.40;
#=GF NC   25.60 26.10;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   8019415
#=GF RT   Novel phosphotransferase system genes revealed by bacterial
#=GF RT   genome analysis: unique, putative fructose- and
#=GF RT   glucoside-specific systems.
#=GF RA   Reizer J., Michotey V., Reizer A., Saier M.H. Jr.;
#=GF RL   Protein Sci. 1994;3:440-450.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the third domain of FrvR and related
#=GF CC   bifunctional regulatory proteins. FrvR contains an N-terminal
#=GF CC   HTH DNA-binding domain (Pfam:PF08279) and a C-terminal PTS EIIA
#=GF CC   type-2 domain (Pfam:PF00359), and may be involved in regulating
#=GF CC   transcription of the frv operon [1]. The family shows similarity
#=GF CC   to BglG-type antiterminators, which regulate sugar utilisation
#=GF CC   operons through RNA-binding and antitermination mechanisms. The
#=GF CC   family is found in Enterobacterales, Lactobacillales and
#=GF CC   Bacillales. The specific function of this third domain remains
#=GF CC   to be determined.
#=GF SQ   19
#=GS A0A1H9LNS7_9LACT/254-334  AC A0A1H9LNS7.1
#=GS A0A099VVS9_9LIST/241-321  AC A0A099VVS9.1
#=GS A0A4P5PK30_9ENTE/252-332  AC A0A4P5PK30.1
#=GS A0A0L0GZT3_9ENTR/247-327  AC A0A0L0GZT3.1
#=GS A0A484Y2B2_9ENTR/247-327  AC A0A484Y2B2.1
#=GS B7L9F0_ECO55/247-327      AC B7L9F0.1
#=GS B7UNL7_ECO27/247-327      AC B7UNL7.1
#=GS A0A544QV05_9FIRM/253-333  AC A0A544QV05.1
#=GS A0A0R1J1X5_9LACO/222-303  AC A0A0R1J1X5.1
#=GS A0A2X3GJB9_9LIST/86-166   AC A0A2X3GJB9.1
#=GS A0A085G0A9_9ENTR/243-323  AC A0A085G0A9.1
#=GS A9MI80_SALAR/3-71         AC A9MI80.1
#=GS A0A485B6D3_KLUCR/30-110   AC A0A485B6D3.1
#=GS A0A660DUJ8_9LACO/248-329  AC A0A660DUJ8.1
#=GS R2T7G5_9ENTE/252-332      AC R2T7G5.1
#=GS A7ZUA7_ECO24/247-327      AC A7ZUA7.1
#=GS Q8X8A7_ECO57/247-327      AC Q8X8A7.1
#=GS Q3YV79_SHISS/247-327      AC Q3YV79.1
#=GS FRVR_ECOLI/247-327        AC P32152.1
A0A1H9LNS7_9LACT/254-334             ...ITKGTILDILLKIEERFEIKLLDMTLVKELVLHITRAISYSFIIEQGEIYNLTNLKAQNPFSFDISLIFANYLQQETGIEV......
A0A099VVS9_9LIST/241-321             ...VTLEQVQQMLQQLAEHYNASVYDLELVEQLTAHLKRSIAYPIILHDRKLHNIANIKAVYPLAFDLSIAFVARANEQFGMEL......
A0A4P5PK30_9ENTE/252-332             ..l-TIAQIEENLNQIEQENNIKFANPKLAKQLYNHLKRILCYPCFLKSKEIHNIANIKALYPFAFDLGIVFIQKMNANY----gyri..
A0A0L0GZT3_9ENTR/247-327             ...ITTQYIAGLLRSLPELTPLHVIDPQLIEDLTGHIVRCSASPVWLPENRQGSMNNLKAAWPAAFDLGIQFINKLREQQDIPV......
A0A484Y2B2_9ENTR/247-327             ...ITPQYVADHLTTLASPAQPQAIDAQLTDELTAHLKRCVAMPNWFPESRPGSMNHLKAAWPAAFDMSVKFINQLRKVMDIPL......
B7L9F0_ECO55/247-327                 ...ISADNVQRLLQRVPGIASLNIIDTQLVENITGHLLRCLAAPVWIAEHRQSSMNNLKAAWPAAFDMSLHFITLLREQLDIPL......
B7UNL7_ECO27/247-327                 ...ISADNVQGLLQRVPGIASLNIIDTQLVENITGHLLRCLAAPVWIGEHRQSSMNNLKAAWPAAFDMSLHFITLLREQLDIPL......
A0A544QV05_9FIRM/253-333             lni---SQIENVLSLIEAENSIRFDNPKLASQLYHHLKRILCYPAYLKNYEVYNISNIKALYPFSFDLSIIFINYMEK------lygyqi
A0A0R1J1X5_9LACO/222-303             .ln--TSFIKEVLRKVTNKYGLRLDETTLVTDITEHLCRNNLFPTFISASLIKQIKDIKIKNPFAFDLANDFRKTIENK-----ipdisi
A0A2X3GJB9_9LIST/86-166              ...ITTGKILDLLQMTYDEHQAPVYDMELAVSLANHLKRSIAYPIILADKKLHNIANIKALYPLAFDLSIHFIGLVNQTFDVLI......
A0A085G0A9_9ENTR/243-323             ...VTTTVIGELTNELLISHGLGELDQQLIDDLTAHIARCAARPLWLQESRQGSMNNLKAAWPVAFDLSIGLINQIRQRLNIEI......
A9MI80_SALAR/3-71                    ..l-SADAVCSLLQRVPGAASLNIIDAQLIDNITGHLLRCVSAPIWLPEHRQSSMNNLKSAWPAAFDMSLR-------------p.....
A0A485B6D3_KLUCR/30-110              ...ISSDTVITLLHSIPGITSLNIIDTQLVDNVTGHLLRSLSAPVWLPENRQGSMNNLKAAWPAAFDMSLHFLARLREKLDIPL......
A0A660DUJ8_9LACO/248-329             ..l-TMRQVHATIEATKIHYTLDSLNHDFTEEIFNHLCRSSMFPTFVPASLSEQIRYLKIQNPFAFDFAFDLAQKLQQDFD---aiqi..
R2T7G5_9ENTE/252-332                 ..l-TIDQIQRVLQVIEQENNITFSNSDLPKQLYHHLKRILCYPTFLKNKEIHNISNIKALYPFAFDLGIVFINYMKKF-----yeyri.
A7ZUA7_ECO24/247-327                 ...ISADHVLGLLQRVPGIASLNIIDTQLVENITGHLLRCLAAPVWIAEHRQSSMNNLKAAWPAAFDMSLHFITLLREQLDIPL......
Q8X8A7_ECO57/247-327                 ...ISADHVLGLLQRVPGLASLNIIDTQLVENITGHLLRCLAAPVWIAEHRQSSMNNLKAAWPAAFDMSLHFITLLREQLDIPL......
Q3YV79_SHISS/247-327                 ...ISADHVLGLLQRVPGIASLNIIDTQLVENITGHLLRCLAAPVWIAEHRQSSMNNLKAAWPAAFDMSLHFITLLREQLDIPL......
FRVR_ECOLI/247-327                   ...ISADNVQGLLQRVPGIASLNIIDAQLVENITGHLLRCLAAPVWIAEHRQSSMNNLKAAWPAAFDMSLHFITLLREQLDIPL......
#=GC seq_cons                        ...losspltslLpplsshssLsllDspLl-slTuHLhRsluhPlals-p+.pshsNLKAsaPhAFDhSlcFIshlccphsl.l......
//