#=GF ID GTP_cyclohydro2
#=GF AC PF00925.24
#=GF DE GTP cyclohydrolase II
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_1147 (release 3.0)
#=GF GA 23.30 23.30;
#=GF TC 23.40 23.30;
#=GF NC 23.20 23.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 8320220
#=GF RT Biosynthesis of riboflavin: cloning, sequencing, mapping, and
#=GF RT expression of the gene coding for GTP cyclohydrolase II in
#=GF RT Escherichia coli.
#=GF RA Richter G, Ritz H, Katzenmeier G, Volk R, Kohnle A, Lottspeich
#=GF RA F, Allendorf D, Bacher A;
#=GF RL J Bacteriol 1993;175:4045-4051.
#=GF DR INTERPRO; IPR032677;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC GTP cyclohydrolase II catalyses the first committed step in the
#=GF CC biosynthesis of riboflavin.
#=GF SQ 14096
#=GS A0A2S2CNG3_9PROT/205-372 AC A0A2S2CNG3.1
#=GS A0A3L7A0X8_9MICO/232-396 AC A0A3L7A0X8.1
#=GS C7MEL3_BRAFD/217-381 AC C7MEL3.1
#=GS A0A5R9LCJ3_9ENTR/4-170 AC A0A5R9LCJ3.1
#=GS A0A0F4J0W2_9ACTN/19-186 AC A0A0F4J0W2.1
#=GS A0A5S5CHW5_9BACL/211-377 AC A0A5S5CHW5.1
#=GS A0A1W2BNK2_9HYPH/213-373 AC A0A1W2BNK2.1
#=GS A0A239I6H1_9SPHN/165-331 AC A0A239I6H1.1
#=GS A0A1A0HH14_9ASCO/143-282 AC A0A1A0HH14.1
#=GS A0A1S8VQD4_9FUNG/364-516 AC A0A1S8VQD4.1
#=GS A0A1I2FYF7_9ACTN/20-187 AC A0A1I2FYF7.1
#=GS A0A177DTK1_ALTAL/711-858 AC A0A177DTK1.1
#=GS A0A2Z6UNN0_GLASK/207-365 AC A0A2Z6UNN0.1
#=GS A0A6J3M883_9PEZI/205-370 AC A0A6J3M883.1
#=GS A0A5D2ZV40_GOSMU/315-482 AC A0A5D2ZV40.1
#=GS A0A285J8U5_9ACTN/206-373 AC A0A285J8U5.1
#=GS A0A8J2MZY4_9PLEO/201-353 AC A0A8J2MZY4.1
#=GS K2JC52_9GAMM/207-369 AC K2JC52.1
#=GS A0A3R9Y5Q8_9BURK/240-394 AC A0A3R9Y5Q8.1
#=GS A0A6M6JK01_9PSEU/232-403 AC A0A6M6JK01.1
#=GS A0A089WRW6_9PSED/207-362 AC A0A089WRW6.1
#=GS A0A5C1Y5J8_9MICO/221-385 AC A0A5C1Y5J8.1
#=GS A0A858R078_9GAMM/4-170 AC A0A858R078.1
#=GS A0A1C7LWC7_GRIFR/356-490 AC A0A1C7LWC7.1
#=GS A0A1N6FT17_9RHOB/205-352 AC A0A1N6FT17.1
#=GS A0A1Q2YCT0_9ASCO/254-406 AC A0A1Q2YCT0.1
#=GS A0A7X5U7X2_9GAMM/20-185 AC A0A7X5U7X2.1
#=GS A0A4R1K3N4_9GAMM/207-368 AC A0A4R1K3N4.1
#=GS A5MZ83_CLOK5/208-374 AC A5MZ83.1
#=GS A0A8X7N5U6_9BASI/462-554 AC A0A8X7N5U6.1
#=GS E1V4D4_HALED/4-170 AC E1V4D4.1
#=GS A0A369GG37_9HYPO/310-398 AC A0A369GG37.1
#=GS A0A4U0VYB7_9BASI/362-507 AC A0A4U0VYB7.1
#=GS Q39V67_GEOMG/207-373 AC Q39V67.1
#=GS S0FUF5_9DELT/207-374 AC S0FUF5.1
#=GS A0A483A8B7_9BACT/208-300 AC A0A483A8B7.1
#=GS I1E2I9_9GAMM/207-368 AC I1E2I9.1
#=GS A0A200QAP2_9MAGN/1-26 AC A0A200QAP2.1
#=GS A0A4S3KIX8_9GAMM/207-362 AC A0A4S3KIX8.1
#=GS A1B2B1_PARDP/222-368 AC A1B2B1.1
#=GS A0A089R541_PLUGE/4-170 AC A0A089R541.1
#=GS A0A1H0F2S3_9ACTN/15-183 AC A0A1H0F2S3.1
#=GS A0A097R3A0_HAFAL/4-170 AC A0A097R3A0.1
#=GS A0A314UTA3_PRUYE/150-315 AC A0A314UTA3.1
#=GS Q9A9S5_CAUVC/205-372 AC Q9A9S5.1
#=GS A0A208XIR1_9BURK/7-169 AC A0A208XIR1.1
#=GS A0A0N9I214_9PSEU/220-387 AC A0A0N9I214.1
#=GS A0A3D8JB39_9HELI/4-170 AC A0A3D8JB39.1
#=GS A0A1A8ZI59_9ACTN/11-187 AC A0A1A8ZI59.1
#=GS A0A563U596_9SPHI/207-373 AC A0A563U596.1
#=GS A0A069PBX2_9BURK/27-194 AC A0A069PBX2.1
#=GS A0A452Z9U8_AEGTS/313-480 AC A0A452Z9U8.1
#=GS A0A3D9FH77_9SPHN/268-422 AC A0A3D9FH77.1
#=GS A0A833SA83_PHYIN/221-356 AC A0A833SA83.1
#=GS A0A1S1V7A7_9FIRM/207-373 AC A0A1S1V7A7.1
#=GS A0A0A7EH99_9GAMM/3-171 AC A0A0A7EH99.1
#=GS A0A286IC20_9HYPH/209-365 AC A0A286IC20.1
#=GS A0A3A5MMA5_9MICO/221-385 AC A0A3A5MMA5.1
#=GS K7L6G1_SOYBN/337-497 AC K7L6G1.1
#=GS A0A2U3MUW9_9GAMM/4-171 AC A0A2U3MUW9.1
#=GS A0A256A195_9FLAO/209-372 AC A0A256A195.1
#=GS W4LQR6_9BACT/222-303 AC W4LQR6.1
#=GS Q5SJF2_THET8/208-374 AC Q5SJF2.1
#=GS A0A1I5U7H2_9PROT/4-168 AC A0A1I5U7H2.1
#=GS A0A231RPZ9_9BACL/209-375 AC A0A231RPZ9.1
#=GS U2HZZ0_9SPHI/210-376 AC U2HZZ0.1
#=GS A4J6A5_DESRM/208-374 AC A4J6A5.1
#=GS A0A8J7NDQ0_9ARCH/206-372 AC A0A8J7NDQ0.1
#=GS A0A2L0VUI4_9SPHN/269-419 AC A0A2L0VUI4.1
#=GS I2GTE1_9BACT/221-387 AC I2GTE1.1
#=GS Q1MS14_LAWIP/220-389 AC Q1MS14.1
#=GS A0A7C9KJS5_9SPHN/181-348 AC A0A7C9KJS5.1
#=GS A0A5C8UJC9_9MICO/221-385 AC A0A5C8UJC9.1
#=GS A0A059FVB2_9PROT/213-369 AC A0A059FVB2.1
#=GS A0A3L7JXI5_9BACI/205-371 AC A0A3L7JXI5.1
#=GS A0A2T1D9U0_9CYAN/224-377 AC A0A2T1D9U0.1
#=GS A0A0Q2UHG1_9RHOB/165-332 AC A0A0Q2UHG1.1
#=GS A0A074WB46_9PEZI/203-370 AC A0A074WB46.1
#=GS A0A8B8N567_9MYRT/1-35 AC A0A8B8N567.1
#=GS A0A1G8FX27_9PROT/198-366 AC A0A1G8FX27.1
#=GS A0A1M6T2V5_PSETH/215-362 AC A0A1M6T2V5.1
#=GS A0A1M7FWY4_9RHOB/221-366 AC A0A1M7FWY4.1
#=GS A0A4Z0CBK9_9BURK/212-369 AC A0A4Z0CBK9.1
#=GS A0A1N7PAS0_9RHOB/190-357 AC A0A1N7PAS0.1
#=GS A0A239FM17_9PROT/201-368 AC A0A239FM17.1
#=GS M1BC15_SOLTU/333-500 AC M1BC15.1
#=GS A0A368MX71_9FLAO/211-372 AC A0A368MX71.1
#=GS A0A7K1XT80_9SPHI/210-376 AC A0A7K1XT80.1
#=GS A0A5D0MG03_9BACT/209-375 AC A0A5D0MG03.1
#=GS A0A511MWJ3_DEIC1/206-370 AC A0A511MWJ3.1
#=GS A0A0U1NKQ7_9RHOB/164-331 AC A0A0U1NKQ7.1
#=GS J5JRF8_BEAB2/191-338 AC J5JRF8.1
#=GS A0A371DCY0_9APHY/327-480 AC A0A371DCY0.1
#=GS A0A239X7T7_9FLAO/3-169 AC A0A239X7T7.1
#=GS A0A5P9CCL8_9PSED/207-357 AC A0A5P9CCL8.1
#=GS A0A6A2XHZ7_HIBSY/287-407 AC A0A6A2XHZ7.1
#=GS F8KSB9_HELBC/5-171 AC F8KSB9.1
#=GS A0A6N8IPG4_9BURK/214-371 AC A0A6N8IPG4.1
#=GS A0A0N0NHI2_9EURO/248-382 AC A0A0N0NHI2.1
#=GS A0A1Q8ZVT2_9HYPH/12-178 AC A0A1Q8ZVT2.1
#=GS A0A1E5RDD2_HANUV/100-251 AC A0A1E5RDD2.1
#=GS A0A4Q9BH66_9BACT/212-378 AC A0A4Q9BH66.1
#=GS A0A1H9A9X5_9FIRM/207-373 AC A0A1H9A9X5.1
#=GS A0A841L5C9_9SPHN/166-334 AC A0A841L5C9.1
#=GS A2X6B6_ORYSI/342-509 AC A2X6B6.1
#=GS B7RWA0_9GAMM/207-366 AC B7RWA0.1
#=GS X0CYV9_FUSOX/311-462 AC X0CYV9.1
#=GS A0A0P6VU69_9HYPH/281-448 AC A0A0P6VU69.1
#=GS A0A1L6J781_9SPHN/222-377 AC A0A1L6J781.1
#=GS R5K559_9CLOT/206-372 AC R5K559.1
#=GS K9WQ80_9CYAN/217-385 AC K9WQ80.1
#=GS A0A840RVW1_9BURK/207-365 AC A0A840RVW1.1
#=GS A0A6L5YUU0_9RHOB/215-362 AC A0A6L5YUU0.1
#=GS A0A453SNU0_AEGTS/260-427 AC A0A453SNU0.1
#=GS A0A0P0ND37_9SPHI/210-376 AC A0A0P0ND37.1
#=GS A0A1I3CJK9_9SPHI/2-166 AC A0A1I3CJK9.1
#=GS A0A848FCS9_9BURK/14-181 AC A0A848FCS9.1
#=GS A0A5C3PGP9_9APHY/261-419 AC A0A5C3PGP9.1
#=GS B4W221_9CYAN/210-378 AC B4W221.1
#=GS S6ALW4_PSERE/207-362 AC S6ALW4.1
#=GS A0A5N5JNJ6_9ROSI/328-495 AC A0A5N5JNJ6.1
#=GS A0A1I1J7U1_9ACTN/6-179 AC A0A1I1J7U1.1
#=GS A0A1X9LLH0_9MICO/214-379 AC A0A1X9LLH0.1
#=GS W9YC80_9EURO/269-418 AC W9YC80.1
#=GS A0A327JG81_9HYPH/208-340 AC A0A327JG81.1
#=GS A0A0U4GST6_9MICO/216-380 AC A0A0U4GST6.1
#=GS M7TUE3_BOTF1/328-478 AC M7TUE3.1
#=GS A0A1Q4YES7_9PSEU/9-175 AC A0A1Q4YES7.1
#=GS A0A0N0CZZ6_9BACT/217-383 AC A0A0N0CZZ6.1
#=GS A0A6M1RS85_9BACT/209-375 AC A0A6M1RS85.1
#=GS A0A512RQB9_9BACT/207-373 AC A0A512RQB9.1
#=GS A0A2A5S0Y7_9LACT/197-363 AC A0A2A5S0Y7.1
#=GS A0A6S6G3R2_9SPHN/223-380 AC A0A6S6G3R2.1
#=GS A0A0D6P9K9_9PROT/214-365 AC A0A0D6P9K9.1
#=GS A0A4R3M4I4_9BURK/221-381 AC A0A4R3M4I4.1
#=GS A0A2N0EWK5_9FLAO/217-381 AC A0A2N0EWK5.1
#=GS A0A8J1VYN5_9DINO/302-456 AC A0A8J1VYN5.1
#=GS A0A8J7KWC7_9FIRM/205-371 AC A0A8J7KWC7.1
#=GS A0A0P0VKQ3_ORYSJ/189-356 AC A0A0P0VKQ3.1
#=GS A0A2A2Z6T2_9ACTN/11-178 AC A0A2A2Z6T2.1
#=GS A0A4R6PV73_NOCIG/210-377 AC A0A4R6PV73.1
#=GS Q9CCP4_MYCLE/220-391 AC Q9CCP4.1
#=GS A0A6A6L1P5_HEVBR/347-514 AC A0A6A6L1P5.1
#=GS A0A080KB75_9GAMM/14-128 AC A0A080KB75.1
#=GS A0A838ZJN0_9FLAO/216-378 AC A0A838ZJN0.1
#=GS N1Q6C8_PSEFD/197-368 AC N1Q6C8.1
#=GS N0B0Z6_9BACI/67-218 AC N0B0Z6.1
#=GS A0A0J6WMG8_MYCCU/212-367 AC A0A0J6WMG8.1
#=GS RIBA_BUCAI/2-168 AC P57359.1
#=GS A0A7Y2PYH4_9MICO/219-384 AC A0A7Y2PYH4.1
#=GS A0A0A0BJP5_9CELL/86-253 AC A0A0A0BJP5.1
#=GS A0A3M6YCZ7_HORWE/217-405 AC A0A3M6YCZ7.1
#=GS Y0KF97_9PROT/210-363 AC Y0KF97.1
#=GS A0A8J5NL12_FUSOX/123-344 AC A0A8J5NL12.1
#=GS A0A066YZY2_9ACTN/222-395 AC A0A066YZY2.1
#=GS A0A1I7F359_9FIRM/229-395 AC A0A1I7F359.1
#=GS F0P0R1_WEEVC/217-379 AC F0P0R1.1
#=GS A0A7I7XWN6_9MYCO/246-400 AC A0A7I7XWN6.1
#=GS A0A2K8STW5_9NOSO/218-386 AC A0A2K8STW5.1
#=GS A0A0N1A5H3_9PROT/207-362 AC A0A0N1A5H3.1
#=GS E0ICE3_9BACL/222-388 AC E0ICE3.1
#=GS G7V9T4_THELD/211-381 AC G7V9T4.1
#=GS A0A0N9V397_SPHMC/269-419 AC A0A0N9V397.1
#=GS A0A194XJS5_9HELO/222-373 AC A0A194XJS5.1
#=GS A0A4R1HMP3_PSEEN/225-396 AC A0A4R1HMP3.1
#=GS A0A1E3X8W5_9BACT/206-381 AC A0A1E3X8W5.1
#=GS C3XBW9_OXAFO/207-368 AC C3XBW9.1
#=GS A0A6J0PAF6_ELAGV/334-501 AC A0A6J0PAF6.1
#=GS A0A0D0ALU6_9AGAM/330-478 AC A0A0D0ALU6.1
#=GS A0A3M8GJN9_9FLAO/216-380 AC A0A3M8GJN9.1
#=GS A0A7S7M0X7_9PROT/4-163 AC A0A7S7M0X7.1
#=GS A0A842HXS5_9SPHN/169-335 AC A0A842HXS5.1
#=GS A0A6S6R1I1_9FIRM/207-373 AC A0A6S6R1I1.1
#=GS A0A1Q4HLG6_9MYCO/214-342 AC A0A1Q4HLG6.1
#=GS A0A4P7GHK6_9ACTN/211-378 AC A0A4P7GHK6.1
#=GS A0A084CM87_9GAMM/5-172 AC A0A084CM87.1
#=GS F1ZCD1_9SPHN/164-335 AC F1ZCD1.1
#=GS A0A0A1DIY3_NOCSI/100-270 AC A0A0A1DIY3.2
#=GS D5VDB9_MORCB/3-169 AC D5VDB9.1
#=GS A0A0M9GQP0_9BACI/208-374 AC A0A0M9GQP0.1
#=GS A0A8J3LSJ0_9ACTN/12-187 AC A0A8J3LSJ0.1
#=GS A0A4Y9YM56_9APHY/248-421 AC A0A4Y9YM56.1
#=GS U2KF81_9FIRM/208-374 AC U2KF81.1
#=GS A0A066UEU7_9GAMM/3-170 AC A0A066UEU7.1
#=GS A0A1A9EUX8_9GAMM/207-368 AC A0A1A9EUX8.1
#=GS A0A4S4C8E0_9BACL/67-215 AC A0A4S4C8E0.1
#=GS A0A397XZM0_BRACM/307-474 AC A0A397XZM0.1
#=GS A0A318KE71_9NOCA/31-172 AC A0A318KE71.1
#=GS A0A7I7MQ57_9MYCO/210-381 AC A0A7I7MQ57.1
#=GS A0A0D6PJV7_9PROT/181-348 AC A0A0D6PJV7.1
#=GS A0A844H1K7_9RHOB/163-329 AC A0A844H1K7.1
#=GS G3XWJ8_ASPNA/235-384 AC G3XWJ8.1
#=GS A0A0E0CMA4_9ORYZ/342-509 AC A0A0E0CMA4.1
#=GS A0A4P8EG46_9RHOB/167-334 AC A0A4P8EG46.1
#=GS A0A174A7A2_9FIRM/207-373 AC A0A174A7A2.1
#=GS A0A4Q3LVA0_9FLAO/175-341 AC A0A4Q3LVA0.1
#=GS M4S564_9SPHN/163-329 AC M4S564.1
#=GS A0A433RS64_9BACL/48-216 AC A0A433RS64.1
#=GS A0A1G7VTC2_9RHOO/214-369 AC A0A1G7VTC2.1
#=GS A0A1N6D837_9BACT/207-373 AC A0A1N6D837.1
#=GS A0A4Q3HY93_9BURK/1-96 AC A0A4Q3HY93.1
#=GS U1JTI1_9GAMM/4-172 AC U1JTI1.1
#=GS A0A328C8E0_9DELT/210-377 AC A0A328C8E0.1
#=GS A0A430KUT6_9GAMM/207-369 AC A0A430KUT6.1
#=GS A0A8J3PEU2_9ACTN/9-176 AC A0A8J3PEU2.1
#=GS A0A845A9V5_9SPHN/268-425 AC A0A845A9V5.1
#=GS W7M9Q5_GIBM7/310-403 AC W7M9Q5.1
#=GS A0A0G2F357_9EURO/327-477 AC A0A0G2F357.1
#=GS K6YJP8_9ALTE/207-365 AC K6YJP8.1
#=GS Q83FM7_TROWT/21-185 AC Q83FM7.1
#=GS A0A5J5HNB9_9BACI/206-372 AC A0A5J5HNB9.1
#=GS A0A4Y9SZ46_9BURK/207-366 AC A0A4Y9SZ46.1
#=GS A0A0Q8PH68_9ACTN/12-177 AC A0A0Q8PH68.1
#=GS A0A1S6XGN7_9HYPH/209-368 AC A0A1S6XGN7.1
#=GS A0A8H8M4L8_9AGAM/273-426 AC A0A8H8M4L8.1
#=GS A0A162FYB2_9MICO/221-297 AC A0A162FYB2.1
#=GS A0A2A2TLT5_9CYAN/204-243 AC A0A2A2TLT5.1
#=GS A0A1Z4BU12_9GAMM/205-366 AC A0A1Z4BU12.1
#=GS A0A7R7VKN8_ASPCH/228-397 AC A0A7R7VKN8.1
#=GS A0A0D3V8N7_9BACL/210-376 AC A0A0D3V8N7.1
#=GS A0A699YH65_HAELA/1-96 AC A0A699YH65.1
#=GS A0A484K8D6_9ASTE/335-502 AC A0A484K8D6.1
#=GS A0A2W1KA30_9FLAO/217-380 AC A0A2W1KA30.1
#=GS A0A7X6S3G9_9LACO/214-376 AC A0A7X6S3G9.1
#=GS Q89RZ7_BRADU/206-354 AC Q89RZ7.1
#=GS B8F5Z7_GLAP5/207-373 AC B8F5Z7.1
#=GS A0A7Y0Q1H5_9FIRM/210-376 AC A0A7Y0Q1H5.1
#=GS E8X4I2_GRATM/7-187 AC E8X4I2.1
#=GS A0A1Y2MGN0_PSEAH/220-364 AC A0A1Y2MGN0.1
#=GS A0A8J7B7U3_9CYAN/217-385 AC A0A8J7B7U3.1
#=GS G7IHK9_MEDTR/312-479 AC G7IHK9.2
#=GS A0A5C6YBF2_9FLAO/217-380 AC A0A5C6YBF2.1
#=GS R5P1M0_9FIRM/207-373 AC R5P1M0.1
#=GS A0A1H0PKD5_9ACTN/220-387 AC A0A1H0PKD5.1
#=GS A0A1N6EH39_9RHOB/216-364 AC A0A1N6EH39.1
#=GS A0A2H5Z761_9BACT/210-376 AC A0A2H5Z761.1
#=GS A3WCH3_9SPHN/592-735 AC A3WCH3.1
#=GS A0A8J7IKG7_9SPHN/161-327 AC A0A8J7IKG7.1
#=GS L2F7S7_9GAMM/206-368 AC L2F7S7.1
#=GS A0A1N6PPX5_9HYPH/212-375 AC A0A1N6PPX5.1
#=GS A0A3M8G3X2_9BACT/190-358 AC A0A3M8G3X2.1
#=GS A0A1I1LNA8_9BURK/7-173 AC A0A1I1LNA8.1
#=GS A0A166RD80_9RHOB/171-338 AC A0A166RD80.1
#=GS A9BVN9_DELAS/230-387 AC A9BVN9.1
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