#=GF ID HAP1_N
#=GF AC PF04849.16
#=GF DE HAP1 N-terminal conserved region
#=GF AU Mifsud W;0000-0002-9805-6461
#=GF SE Pfam-B_4571 (release 7.6)
#=GF GA 33.90 33.90;
#=GF TC 33.90 33.90;
#=GF NC 33.80 33.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 7477378
#=GF RT A huntingtin-associated protein enriched in brain with
#=GF RT implications for pathology.
#=GF RA Li XJ, Li SH, Sharp AH, Nucifora FC Jr, Schilling G, Lanahan A,
#=GF RA Worley P, Snyder SH, Ross CA;
#=GF RL Nature 1995;378:398-402.
#=GF RN [2]
#=GF RM 9599014
#=GF RT HAP1-huntingtin interactions do not contribute to the molecular
#=GF RT pathology in Huntington's disease transgenic mice.
#=GF RA Bertaux F, Sharp AH, Ross CA, Lehrach H, Bates GP, Wanker E;
#=GF RL FEBS Lett 1998;426:229-232.
#=GF RN [3]
#=GF RM 9285789
#=GF RT Huntingtin-associated protein 1 (HAP1) binds to a Trio-like
#=GF RT polypeptide, with a rac1 guanine nucleotide exchange factor
#=GF RT domain.
#=GF RA Colomer V, Engelender S, Sharp AH, Duan K, Cooper JK, Lanahan A,
#=GF RA Lyford G, Worley P, Ross CA;
#=GF RL Hum Mol Genet 1997;6:1519-1525.
#=GF RN [4]
#=GF RM 11161814
#=GF RT Cloning and characterization of three novel genes, ALS2CR1,
#=GF RT ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral
#=GF RT sclerosis (ALS2) critical region at chromosome 2q33-q34:
#=GF RT candidate genes for ALS2.
#=GF RA Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale
#=GF RA D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J,
#=GF RA Hayden MR;
#=GF RL Genomics 2001;71:200-213.
#=GF DR INTERPRO; IPR006933;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family represents an N-terminal conserved region found in
#=GF CC several huntingtin-associated protein 1 (HAP1) homologues. HAP1
#=GF CC binds to huntingtin in a polyglutamine repeat-length-dependent
#=GF CC manner. However, its possible role in the pathogenesis of
#=GF CC Huntington's disease is unclear [1-3]. This family also includes
#=GF CC a similar N-terminal conserved region from hypothetical protein
#=GF CC products of ALS2CR3 genes found in the human juvenile
#=GF CC amyotrophic lateral sclerosis critical region 2q33-2q34 [4].
#=GF SQ 2573
#=GS A0A6I9PNL6_9TELE/43-321 AC A0A6I9PNL6.1
#=GS A0A2K5XV87_MANLE/4-247 AC A0A2K5XV87.1
#=GS A0A7R5K4K0_9PASS/1-290 AC A0A7R5K4K0.1
#=GS A0A673ZF78_SALTR/1-290 AC A0A673ZF78.1
#=GS A0A674J6N3_TERCA/1-253 AC A0A674J6N3.1
#=GS A0A2K5PXT4_CEBIM/48-353 AC A0A2K5PXT4.1
#=GS A0A672T8M7_SINGR/3-154 AC A0A672T8M7.1
#=GS H3E2L1_PRIPA/18-242 AC H3E2L1.2
#=GS A0A1D1V855_RAMVA/9-282 AC A0A1D1V855.1
#=GS A0A671MIN0_9TELE/1-237 AC A0A671MIN0.1
#=GS A0A663MEG2_ATHCN/6-279 AC A0A663MEG2.1
#=GS A0A1X7VL83_AMPQE/126-361 AC A0A1X7VL83.1
#=GS A0A672GBC0_SALFA/46-351 AC A0A672GBC0.1
#=GS A0A6P5KC06_PHACI/1-249 AC A0A6P5KC06.1
#=GS A0A5F4CPZ9_CANLF/175-271 AC A0A5F4CPZ9.1
#=GS A0A7N6AHI9_ANATE/42-347 AC A0A7N6AHI9.1
#=GS A0A667ZZ80_9TELE/1-245 AC A0A667ZZ80.1
#=GS A0A669E690_ORENI/10-287 AC A0A669E690.1
#=GS A0A6P7KNJ8_BETSP/8-283 AC A0A6P7KNJ8.1
#=GS A0A484CLR7_PERFV/98-402 AC A0A484CLR7.1
#=GS A0A556TVJ4_BAGYA/72-376 AC A0A556TVJ4.1
#=GS A0A7N4NQD8_SARHA/9-294 AC A0A7N4NQD8.1
#=GS A0A0Q9WBH1_DROVI/1-238 AC A0A0Q9WBH1.1
#=GS MILT_DROME/107-381 AC Q960V3.1
#=GS A0A668VX14_OREAU/23-306 AC A0A668VX14.1
#=GS A0A673JWA2_9TELE/44-346 AC A0A673JWA2.1
#=GS A0A6P3WSM8_DINQU/35-335 AC A0A6P3WSM8.1
#=GS A0A7N4PKL2_SARHA/1-232 AC A0A7N4PKL2.1
#=GS A0A671WV28_SPAAU/12-287 AC A0A671WV28.1
#=GS A0A3P8W8J3_CYNSE/53-379 AC A0A3P8W8J3.1
#=GS A0NE58_ANOGA/73-126 AC A0NE58.2
#=GS A0A668VYR1_OREAU/17-320 AC A0A668VYR1.1
#=GS A0A0Q3Q6F9_AMAAE/182-487 AC A0A0Q3Q6F9.1
#=GS A0A672QBD0_SINGR/31-348 AC A0A672QBD0.1
#=GS A0A484B621_DRONA/72-127 AC A0A484B621.1
#=GS A0A5F8HAG5_MONDO/1-249 AC A0A5F8HAG5.1
#=GS A0A6A5DZ10_SCHHA/1024-1175 AC A0A6A5DZ10.1
#=GS A0A673WSE3_SALTR/22-327 AC A0A673WSE3.1
#=GS A0A6J2QZL1_COTGO/32-361 AC A0A6J2QZL1.1
#=GS A0A7N5P8T0_AILME/76-381 AC A0A7N5P8T0.1
#=GS A0A402FRG1_9SAUR/29-105 AC A0A402FRG1.1
#=GS A0A674IN53_TERCA/54-116 AC A0A674IN53.1
#=GS A0A672TBT9_SINGR/3-154 AC A0A672TBT9.1
#=GS A0A6J3BBJ6_VICPA/11-295 AC A0A6J3BBJ6.1
#=GS A0A341C4R3_NEOAA/1-249 AC A0A341C4R3.1
#=GS A0A553R943_9TELE/29-435 AC A0A553R943.1
#=GS A0A5C6NE55_9TELE/79-516 AC A0A5C6NE55.1
#=GS F4W746_ACREC/156-226 AC F4W746.1
#=GS A0A670Z2J1_PSETE/24-329 AC A0A670Z2J1.1
#=GS A0A673WE39_SALTR/25-329 AC A0A673WE39.1
#=GS A0A2Y9G6G5_NEOSC/10-295 AC A0A2Y9G6G5.1
#=GS A0A3Q3NHZ4_9TELE/2-266 AC A0A3Q3NHZ4.2
#=GS A0A4U8UWK2_STECR/89-186 AC A0A4U8UWK2.1
#=GS A0A6J0CI26_PERMB/81-402 AC A0A6J0CI26.1
#=GS A0A3Q3XGF0_MOLML/44-344 AC A0A3Q3XGF0.1
#=GS A0A668W0E0_OREAU/1-256 AC A0A668W0E0.1
#=GS C9JC32_HUMAN/11-295 AC C9JC32.1
#=GS A0A151JS49_9HYME/203-289 AC A0A151JS49.1
#=GS A0A183T7J7_SCHSO/104-243 AC A0A183T7J7.1
#=GS A0A6P6D937_OCTDE/1-249 AC A0A6P6D937.1
#=GS A0A4W5JST7_9TELE/24-345 AC A0A4W5JST7.1
#=GS A0A673KCJ5_9TELE/71-364 AC A0A673KCJ5.1
#=GS A0A6J0AJB1_VICPA/48-353 AC A0A6J0AJB1.1
#=GS A0A3Q2CSX6_CYPVA/13-300 AC A0A3Q2CSX6.1
#=GS A0A1Y3BGY4_EURMA/1-117 AC A0A1Y3BGY4.1
#=GS A0A3Q1EMG7_9TELE/24-214 AC A0A3Q1EMG7.1
#=GS A0A0L8GQ86_OCTBM/29-332 AC A0A0L8GQ86.1
#=GS A0A6G1QYV7_9TELE/1-248 AC A0A6G1QYV7.1
#=GS A0A2R8QKZ4_DANRE/13-303 AC A0A2R8QKZ4.1
#=GS A0A672S9Q5_SINGR/2-260 AC A0A672S9Q5.1
#=GS M7CHS9_CHEMY/1-281 AC M7CHS9.1
#=GS A0A6P3H566_BISBI/9-294 AC A0A6P3H566.1
#=GS A0A7N8X024_9TELE/19-320 AC A0A7N8X024.1
#=GS A0A643BZZ5_BALPH/17-390 AC A0A643BZZ5.1
#=GS F7BBN9_MONDO/47-352 AC F7BBN9.3
#=GS A0A6J3QKQ7_TURTR/108-350 AC A0A6J3QKQ7.1
#=GS A0A6J3QL44_TURTR/108-350 AC A0A6J3QL44.1
#=GS A0A6J1XW64_ACIJB/1-249 AC A0A6J1XW64.1
#=GS A0A5E4C0P9_MARMO/48-353 AC A0A5E4C0P9.1
#=GS A0A4W3HXG2_CALMI/38-343 AC A0A4W3HXG2.1
#=GS G3UCX8_LOXAF/48-353 AC G3UCX8.1
#=GS A0A2K6LH99_RHIBE/3-248 AC A0A2K6LH99.1
#=GS A0A151PCC7_ALLMI/99-404 AC A0A151PCC7.1
#=GS A0A6J3QKR2_TURTR/108-451 AC A0A6J3QKR2.1
#=GS A0A4Z2D5W8_SCHJA/1-265 AC A0A4Z2D5W8.1
#=GS A0A0L8GQ90_OCTBM/29-345 AC A0A0L8GQ90.1
#=GS A0A4W5JHR9_9TELE/53-209 AC A0A4W5JHR9.1
#=GS A0A670JLF2_PODMU/19-318 AC A0A670JLF2.1
#=GS A0A2G5VMJ5_9PELO/15-246 AC A0A2G5VMJ5.1
#=GS A0A6J0XJX6_ODOVR/1-249 AC A0A6J0XJX6.1
#=GS A0A1U8D363_ALLSI/30-357 AC A0A1U8D363.1
#=GS A0A437CU21_ORYJA/1-279 AC A0A437CU21.1
#=GS R0LTF2_ANAPL/18-320 AC R0LTF2.1
#=GS A0A4W5PM71_9TELE/1-292 AC A0A4W5PM71.1
#=GS A0A671MFI3_9TELE/18-309 AC A0A671MFI3.1
#=GS A0A340XVQ1_LIPVE/221-341 AC A0A340XVQ1.1
#=GS A0A3P9PMN0_POERE/82-147 AC A0A3P9PMN0.1
#=GS A0A3Q0EBI2_CARSF/5-279 AC A0A3Q0EBI2.1
#=GS A0A183EDI1_9BILA/1-94 AC A0A183EDI1.1
#=GS A0A287APB7_PIG/1-249 AC A0A287APB7.1
#=GS A0A669EG54_ORENI/3-274 AC A0A669EG54.1
#=GS A0A673K7C0_9TELE/1-246 AC A0A673K7C0.1
#=GS A0A6P3WRI2_DINQU/20-320 AC A0A6P3WRI2.1
#=GS A0A6P8WCY1_GYMAC/119-422 AC A0A6P8WCY1.1
#=GS A0A484D9M5_PERFV/110-415 AC A0A484D9M5.1
#=GS A0A0L8GPK2_OCTBM/1-253 AC A0A0L8GPK2.1
#=GS A0A6P6GZB1_PUMCO/6-279 AC A0A6P6GZB1.1
#=GS A0A7M7QNP5_NASVI/1-240 AC A0A7M7QNP5.1
#=GS A0A4S2LUA5_OPIFE/150-456 AC A0A4S2LUA5.1
#=GS A0A2I3GSC5_NOMLE/104-412 AC A0A2I3GSC5.1
#=GS A0A2Y9M3J3_DELLE/108-423 AC A0A2Y9M3J3.1
#=GS W5NZ46_SHEEP/17-322 AC W5NZ46.1
#=GS A0A2K5XVE5_MANLE/6-279 AC A0A2K5XVE5.1
#=GS H2NU26_PONAB/107-451 AC H2NU26.1
#=GS A0A7N4UZ18_SARHA/5-279 AC A0A7N4UZ18.1
#=GS A0A3Q1HID3_ANATE/1-244 AC A0A3Q1HID3.2
#=GS A0A2I0LLY6_COLLI/1-91 AC A0A2I0LLY6.1
#=GS A0A3Q3EQ07_9LABR/1-249 AC A0A3Q3EQ07.1
#=GS S9YNA6_CAMFR/54-212 AC S9YNA6.1
#=GS A0A6P6NTD7_CARAU/29-348 AC A0A6P6NTD7.1
#=GS A0A553QL25_9TELE/82-318 AC A0A553QL25.1
#=GS A0A401NPM3_SCYTO/36-341 AC A0A401NPM3.1
#=GS M4A2T9_XIPMA/41-345 AC M4A2T9.2
#=GS H2RXI0_TAKRU/13-282 AC H2RXI0.3
#=GS A0A0L8GPS7_OCTBM/29-332 AC A0A0L8GPS7.1
#=GS A0A669QCD8_PHACC/44-304 AC A0A669QCD8.1
#=GS A0A1S3RZB0_SALSA/1-249 AC A0A1S3RZB0.1
#=GS A0A672Z4W8_9TELE/8-227 AC A0A672Z4W8.1
#=GS A0A674PRK3_TAKRU/13-283 AC A0A674PRK3.1
#=GS A0A6J0VWN1_ODOVR/6-279 AC A0A6J0VWN1.1
#=GS A0A5F8GJ88_MONDO/5-279 AC A0A5F8GJ88.1
#=GS G3UFL9_LOXAF/1-258 AC G3UFL9.1
#=GS A0A3P4NMU3_GULGU/1-249 AC A0A3P4NMU3.1
#=GS A0A0L8GQ25_OCTBM/2-275 AC A0A0L8GQ25.1
#=GS A0A091S343_NESNO/1-234 AC A0A091S343.1
#=GS A0A671MKX1_9TELE/19-324 AC A0A671MKX1.1
#=GS A0A2Y9K6N8_ENHLU/255-586 AC A0A2Y9K6N8.1
#=GS A0A6I8U9G3_AEDAE/179-450 AC A0A6I8U9G3.1
#=GS A0A6P4IMZ4_DROKI/227-518 AC A0A6P4IMZ4.1
#=GS A0A7M7QQH0_NASVI/92-393 AC A0A7M7QQH0.1
#=GS A0A452QR53_URSAM/3-239 AC A0A452QR53.1
#=GS A0A2I3GQS7_NOMLE/4-240 AC A0A2I3GQS7.1
#=GS A0A7E6F0E1_OCTVU/3-253 AC A0A7E6F0E1.1
#=GS A0A674J182_TERCA/30-335 AC A0A674J182.1
#=GS A0A671MMU9_9TELE/7-267 AC A0A671MMU9.1
#=GS A0A6I9PIU8_9TELE/90-205 AC A0A6I9PIU8.1
#=GS F6QS89_CALJA/2-279 AC F6QS89.2
#=GS A0A455C1W2_PHYMC/5-260 AC A0A455C1W2.1
#=GS A0A4W4FC81_ELEEL/6-279 AC A0A4W4FC81.1
#=GS A0A4W4FAL3_ELEEL/6-274 AC A0A4W4FAL3.1
#=GS A0A671SF80_9TELE/18-267 AC A0A671SF80.1
#=GS A0A226PV16_COLVI/16-135 AC A0A226PV16.1
#=GS A0A3M0JKW3_HIRRU/34-92 AC A0A3M0JKW3.1
#=GS A0A402E8S3_9SAUR/140-289 AC A0A402E8S3.1
#=GS S7MFR3_MYOBR/113-418 AC S7MFR3.1
#=GS A0A1S2ZD20_ERIEU/5-295 AC A0A1S2ZD20.1
#=GS A0A444TTV6_ARMVU/1-137 AC A0A444TTV6.1
#=GS A0A2K5I7T7_COLAP/48-353 AC A0A2K5I7T7.1
#=GS A0A194RCJ1_PAPMA/47-100 AC A0A194RCJ1.1
#=GS A0A6P7JMT7_9TELE/124-427 AC A0A6P7JMT7.1
#=GS A0A3Q1M7K0_BOVIN/48-353 AC A0A3Q1M7K0.1
#=GS A0A6P8QG08_GEOSA/19-324 AC A0A6P8QG08.1
#=GS A0A4U5TXP3_COLLU/32-359 AC A0A4U5TXP3.1
#=GS M7B7W9_CHEMY/337-632 AC M7B7W9.1
#=GS A0A669CIU3_ORENI/1-237 AC A0A669CIU3.1
#=GS A0A3N0Y746_ANAGA/33-395 AC A0A3N0Y746.1
#=GS A0A1V4K793_PATFA/144-449 AC A0A1V4K793.1
#=GS A0A7N4V676_SARHA/1-249 AC A0A7N4V676.1
#=GS A0A504YT73_FASGI/32-156 AC A0A504YT73.1
#=GS A0A673WR21_SALTR/1-249 AC A0A673WR21.1
#=GS A0A2K6GNQ4_PROCO/3-246 AC A0A2K6GNQ4.1
#=GS A0A2K6G7Y9_PROCO/48-118 AC A0A2K6G7Y9.1
#=GS A0A2U3VFM6_ODORO/48-353 AC A0A2U3VFM6.1
#=GS A0A3Q3H0E9_KRYMA/10-287 AC A0A3Q3H0E9.1
#=GS A0A485PJA2_LYNPA/1-249 AC A0A485PJA2.1
#=GS A0A6P8J3M6_ACTTE/1-267 AC A0A6P8J3M6.1
#=GS A0A6P7SNE9_OCTVU/112-428 AC A0A6P7SNE9.1
#=GS G3QHQ9_GORGO/48-353 AC G3QHQ9.2
#=GS A0A6P6R2J4_CARAU/23-309 AC A0A6P6R2J4.1
#=GS A0A1U8CGR7_MESAU/12-302 AC A0A1U8CGR7.1
#=GS A0A6P9AVI5_PANGU/1-249 AC A0A6P9AVI5.1
#=GS A0A2K6CR21_MACNE/6-279 AC A0A2K6CR21.1
#=GS A0A2A4JV16_HELVI/47-343 AC A0A2A4JV16.1
#=GS A0A4U5U4J2_COLLU/51-404 AC A0A4U5U4J2.1
#=GS A0A4U1F6P0_MONMO/48-351 AC A0A4U1F6P0.1
#=GS A0A384DMX1_URSMA/48-353 AC A0A384DMX1.1
#=GS G3RAK0_GORGO/155-260 AC G3RAK0.2
#=GS A0A673YYM5_SALTR/23-328 AC A0A673YYM5.1
#=GS A0A6J3QJZ9_TURTR/108-350 AC A0A6J3QJZ9.1
#=GS A0A673K5B6_9TELE/71-364 AC A0A673K5B6.1
#=GS A0A673MU81_9TELE/19-324 AC A0A673MU81.1
#=GS A0A0M5IYA0_DROBS/77-163 AC A0A0M5IYA0.1
#=GS A0A6J0V3D1_9SAUR/30-354 AC A0A6J0V3D1.1
#=GS A0A6J3KMK4_9HYME/147-447 AC A0A6J3KMK4.1
#=GS A0A2K5V7Y0_MACFA/12-64 AC A0A2K5V7Y0.2
#=GS A0A670JRT3_PODMU/399-704 AC A0A670JRT3.1
#=GS A0A0T6BFE7_9SCAR/1-137 AC A0A0T6BFE7.1
#=GS A0A3Q0CFM4_MESAU/81-413 AC A0A3Q0CFM4.1
#=GS A0A6I8NB58_ORNAN/6-279 AC A0A6I8NB58.1
#=GS A0A6P7KYX8_BETSP/146-449 AC A0A6P7KYX8.1
#=GS A0A3P7M0Y7_LITSI/1-147 AC A0A3P7M0Y7.1
#=GS A0A672GPY9_SALFA/2-252 AC A0A672GPY9.1
#=GS A0A183EDI1_9BILA/94-219 AC A0A183EDI1.1
#=GS A0A091VKP7_OPIHO/56-361 AC A0A091VKP7.1
#=GS A0A6P6D9L9_OCTDE/11-292 AC A0A6P6D9L9.1
#=GS A0A0Q9X518_DROMO/112-397 AC A0A0Q9X518.1
#=GS A0A6P8PAZ0_GEOSA/1-249 AC A0A6P8PAZ0.1
#=GS A0A7F8RS11_LEPWE/132-208 AC A0A7F8RS11.1
#=GS A0A6P6LJC6_CARAU/19-324 AC A0A6P6LJC6.1
#=GS A0A0V0WL30_9BILA/175-391 AC A0A0V0WL30.1
#=GS A0A672S837_SINGR/7-266 AC A0A672S837.1
#=GS A0A2I0LQ96_COLLI/30-334 AC A0A2I0LQ96.1
#=GS A0A673K9C4_9TELE/28-320 AC A0A673K9C4.1
#=GS Q80VE1_MOUSE/47-236 AC Q80VE1.1
#=GS A0A6P7NVR4_BETSP/1-248 AC A0A6P7NVR4.1
#=GS A0A665TVZ2_ECHNA/6-277 AC A0A665TVZ2.1
#=GS A0A674N955_TAKRU/32-361 AC A0A674N955.1
#=GS B4Q5C2_DROSI/107-381 AC B4Q5C2.1
#=GS A0A158QBR8_HYMDI/125-246 AC A0A158QBR8.1
#=GS A0A2I0LRC7_COLLI/144-449 AC A0A2I0LRC7.1
#=GS A0A6J2KF59_BOMMA/2-256 AC A0A6J2KF59.1
#=GS A0A5J4NBX6_9TREM/245-331 AC A0A5J4NBX6.1
#=GS A0A7F8RSU9_LEPWE/132-454 AC A0A7F8RSU9.1
#=GS A0A6P8WCU8_GYMAC/1-244 AC A0A6P8WCU8.1
#=GS A0A3P7JJ16_STRVU/1-184 AC A0A3P7JJ16.1
#=GS A0A482WP92_LAOST/49-125 AC A0A482WP92.1
#=GS A0A3P7DYD3_WUCBA/4-229 AC A0A3P7DYD3.1
#=GS A0A668U2R9_OREAU/6-276 AC A0A668U2R9.1
#=GS A0A671UNC7_SPAAU/14-317 AC A0A671UNC7.1
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