GenomeNet

Database: Pfam
Entry: HBD
LinkDB: HBD
Original site: HBD 
#=GF ID   HBD
#=GF AC   PF18534.4
#=GF DE   Helical bundle domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF05780
#=GF GA   32.90 32.90;
#=GF TC   39.50 38.00;
#=GF NC   28.80 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   25821953
#=GF RT   Lpg0393 of Legionella pneumophila is a guanine-nucleotide
#=GF RT   exchange factor for Rab5, Rab21 and Rab22.
#=GF RA   Sohn YS, Shin HC, Park WS, Ge J, Kim CH, Lee BL, Heo WD, Jung
#=GF RA   JU, Rigden DJ, Oh BH;
#=GF RL   PLoS One. 2015;10:e0118683.
#=GF DR   INTERPRO; IPR041321;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Lpg0393 is a Legionella pneumophila effector protein. Structure
#=GF CC   analysis reveals that it has two domains, the N-terminal domain
#=GF CC   is a Vps9-like domain, which is structurally most similar to the
#=GF CC   catalytic core of human Rabex-5 that activates the endosomal Rab
#=GF CC   proteins Rab5, Rab21 and Rab22. The C-terminal domain is a
#=GF CC   helical bundle domain. The C-terminal helical bundle of Lpg0393
#=GF CC   corresponds to the N-terminal helical bundle of Rabex-5, it
#=GF CC   lacks an obvious region that corresponds to the membrane-binding
#=GF CC   motif of Rabex-5. One possibility may be that Lpg0393
#=GF CC   localization to endosomes depends on an unknown Legionella
#=GF CC   effector [1].
#=GF SQ   16
#=GS A0A0W0Z085_LEGSP/178-260  AC A0A0W0Z085.1
#=GS A0A433JYW7_9GAMM/168-251  AC A0A433JYW7.1
#=GS A0A098G7Z8_9GAMM/169-252  AC A0A098G7Z8.1
#=GS A0A0W1A2B3_9GAMM/173-256  AC A0A0W1A2B3.1
#=GS A0A0W0VPR2_9GAMM/171-255  AC A0A0W0VPR2.1
#=GS A0A0W0ZZJ1_9GAMM/165-248  AC A0A0W0ZZJ1.1
#=GS A0A0W0XM53_9GAMM/168-248  AC A0A0W0XM53.1
#=GS G9ET11_9GAMM/170-255      AC G9ET11.1
#=GS Q5ZYH9_LEGPH/169-252      AC Q5ZYH9.1
#=GS Q5ZYH9_LEGPH/169-252      DR PDB; 4R0G B; 169-252;
#=GS Q5ZYH9_LEGPH/169-252      DR PDB; 4R0G D; 169-252;
#=GS Q5ZYH9_LEGPH/169-252      DR PDB; 4R0G C; 169-252;
#=GS Q5ZYH9_LEGPH/169-252      DR PDB; 4R0G A; 169-252;
#=GS A0A222P5K2_9GAMM/165-245  AC A0A222P5K2.1
#=GS A0A0W1AJY9_9GAMM/169-252  AC A0A0W1AJY9.1
#=GS A0A0W0VF10_9GAMM/166-248  AC A0A0W0VF10.1
#=GS A0A378I5R3_9GAMM/165-253  AC A0A378I5R3.1
#=GS A0A6F8T261_9GAMM/177-259  AC A0A6F8T261.1
#=GS A0A378LWV1_9GAMM/165-248  AC A0A378LWV1.1
#=GS A0A0W0Z2M4_9GAMM/169-252  AC A0A0W0Z2M4.1
A0A0W0Z085_LEGSP/178-260             ...MEYRDLILEYLDELSR-RQE..DDH.CA.SVRLGVVLALREYLMGQTLVTAGVKDHISKYVRKLE.EENPQ...PWENE.YLARLSPKSISER....
A0A433JYW7_9GAMM/168-251             ..l-NLRQTVRRYLDALERPSSV..NDE.LK.ATRLSVLRRLNTFLYEQTVLNSKVRYEIDGYISKLG.DLAPQ...KFEEV.YIMELTSSPL---lkt.
A0A098G7Z8_9GAMM/169-252             ..a-KRRYITEEYSLQLGATKQV..GDL.LK.NSRLSVVKRLARYLNEQSELTEEVHLEITTYVAKIK.ELQPA...GFEKE.YLQALLAPSLLEN....
A0A0W1A2B3_9GAMM/173-256             ..a-RVRSVIDRYLTALQSSSDS..LDK.LK.STRYSLVVRLAIYFQEQTEITSEVTAQIEEYVKQIR.LSQPS...DDEEQ.FLEQLAPLSFTES....
A0A0W0VPR2_9GAMM/171-255             ...FNCQLLLQTYVEELAKYHDK..DDNgFT.AVRLGVINSLTHYLCDKTIMTEEVENKIASFVNKIQ.EMDPK...DWEKL.LLDKMRPKTSSDK....
A0A0W0ZZJ1_9GAMM/165-248             ...TRPRYLLEDYILHLERIKLK..DDE.LY.ATRLSMANRFLRYLYEQTELTQEVAEVIATYASSLR.EFHPG...KKEVD.QLDEISPPSTLEH....
A0A0W0XM53_9GAMM/168-248             lqq---LELCEAYVEELKN---Q..SDK.AF.ALRAGVAQALLDQFKRK-IGSDDCENLLKGYVNKLR.EMRPD...IWEENlYLSKLAPKNVLE-d...
G9ET11_9GAMM/170-255                 ..v-EPLTVLEEYLRLLNLVHAQecSNP.LY.NTRLGIVQSFFSYLREQTELSEDRIHKMIIYVNAIR.CHQPE...AWEEE.HLHKIFPPTLVEK....
Q5ZYH9_LEGPH/169-252                 ..t-YLKYLIEDYLSLLESAHLP..TDQ.LK.SSRISLVVRLAKYLHEQTELTQDVHDEIAVYVKKLW.EMQPA...EFEEE.FLKKISPLPFIDN....
#=GR Q5ZYH9_LEGPH/169-252      SS    ..H-HHHHHHHHHHHHHHTSSSS..S-S.HH.HHHHHHHHHHHHHHHT-SS--HHHHHHHHHHHHHHH.TT---...HHHHH.HHHHHSHHHHHHH....
A0A222P5K2_9GAMM/165-245             ..l-QCQAMLKEYVIKLAS-AEN..KEG.FY.PVRQGLINSLHRFVMEKTITTPDVIETLNRFAEKIL.KMEPA...LWEKE.ILDQLIV------knke
A0A0W1AJY9_9GAMM/169-252             ..t-QPRYLTDEYITVLEHAQIA..NDQ.LH.PSRLSLIKRLAQYLKEQTEYTEQVKEEIGVYVARLW.EMNPA...PFEEE.YLNALSTGTSI--an..
A0A0W0VF10_9GAMM/166-248             ..l-EVKHLLKLYLEKLTSV-PP..EGE.FH.AIRQGLLQSLQMYLKDKTIAAKEILEEISSFILALK.KMEPH...DWEMA.YLDKMLPNGSVN-k...
A0A378I5R3_9GAMM/165-253             ..a-SYQALCLEYINLLSNFSPE..QTT.VKtGLRLGIAQSLHEYLCHQVMLTPEIKQEIMAYLNKINaELEPGlafKWEEA.YLKKLEDKTIF--qr..
A0A6F8T261_9GAMM/177-259             ..a-NLRYLVEEYSTQLEL-SEI..CDE.LK.SSRLSVAKRLAQYLNGQSELSATVTAEIKLYVDKIM.NMQPT...DFEKQ.YLLTLSPQSF---dkt.
A0A378LWV1_9GAMM/165-248             ...TKPRYLLEEYILYLERLKLK..DDA.LY.ITRLSMANRLLVFLYEQTEMNLEVSREIAHYVNALR.ELHAG...KEELD.RLDSISPPSILEN....
A0A0W0Z2M4_9GAMM/169-252             ..v-QLRYLIEEYRRTLELAELP..EDQ.LK.STRISVIIRLGRYLDEQMELTPEVTEEIASYVKKLW.EMHPT...VFEED.YLKTLSPLSFVDN....
#=GC SS_cons                         ..H-HHHHHHHHHHHHHHTSSSS..S-S.HH.HHHHHHHHHHHHHHHT-SS--HHHHHHHHHHHHHHH.TT---...HHHHH.HHHHHSHHHHHHH....
#=GC seq_cons                        ..h.ph+hLl--YlptLpphp.t..sDp.Lp.uoRLullppLtpYLpEQT.lTp-VppcIssYVsKlp.EhpPs...taEcp.aLcpLsP.ohh-.....
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