GenomeNet

Database: Pfam
Entry: HHV6-IE
LinkDB: HHV6-IE
Original site: HHV6-IE 
#=GF ID   HHV6-IE
#=GF AC   PF03753.16
#=GF DE   Human herpesvirus 6 immediate early protein 
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_1006 (release 7.0)
#=GF GA   25.00 25.00;
#=GF TC   73.40 73.10;
#=GF NC   20.40 20.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11596096
#=GF RT   Human herpesvirus 6 downregulates major histocompatibility
#=GF RT   complex class I in dendritic cells. 
#=GF RA   Hirata Y, Kondo K, Yamanishi K; 
#=GF RL   J Med Virol 2001;65:576-583.
#=GF DR   INTERPRO; IPR005507;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The proteins in this family are poorly characterised, but an
#=GF CC   investigation [1]has indicated that the immediate early protein
#=GF CC   is required the down-regulation of MHC class I expression in
#=GF CC   dendritic cells. Human herpesvirus 6 immediate early protein is
#=GF CC   also referred to as U90.
#=GF SQ   14
#=GS Q69514_HHV7J/1-545        AC Q69514.1
#=GS IE1_HHV6U/435-520         AC Q69567.2
#=GS IE2_HHV6U/2-109           AC Q77Z83.2
#=GS A0A191S3S2_9BETA/1-729    AC A0A191S3S2.1
#=GS Q69515_HHV7J/7-85         AC Q69515.1
#=GS W8FUA8_9BETA/1-334        AC W8FUA8.1
#=GS A0A191S3S2_9BETA/720-974  AC A0A191S3S2.1
#=GS U90_HHV6Z/1-1078          AC Q77PU6.1
#=GS Q69514_HHV7J/842-1050     AC Q69514.1
#=GS IE1_HHV6U/2-436           AC Q69567.2
#=GS IE1_HHV6U/518-941         AC Q69567.2
#=GS W8FUA8_9BETA/333-418      AC W8FUA8.1
#=GS W8FUA8_9BETA/416-839      AC W8FUA8.1
#=GS W8FQV6_9BETA/1-85         AC W8FQV6.1
Q69514_HHV7J/1-545                   ....................................----------------------------------------------------------------------------------------------------------..--------------MDQEKADIEDCLINHAGILTNDRHMLTDLALEQLSQMLNVNLISGASSGFISFYEDILSGEQLEFFLWCESRYTVYACDKFDEIVKKVIADCREYLSDLRNNMDREFIKCIKKIISMGNFISSNEKLNRCATMLLMMGKNRDITDINISNQAFYIKTNKIKKDLLECKFEIIEKNSRIAQTMKDFAIKQMNQMFMSMCDETFLKIHFNCINLIEAAKNLGAAVLQCIVICSKEFSCKKFRANRKEFKITLMHMINDACDQIEKLYDVTGEVTVLNSISIRNGYVTGNGHHSSTLLESHLYNSDSTPPEIEDFNDYGKYSEECSE..TSEQSYQSVHQNVSPTQcVSKSEQ......YNVQSNFSDIC......QTIKTTLAVSQAS........DES....HSKNTTgKNPEVCTR..EYKLDFFEEIDTQNLAKkvvsKDSPDCLMYPAETNPG---------------------------------------------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------msteesevnvsegtdtqdfsrnticrflsdnpiisveknsevnaiknetglseaaatqdffkeatmkscrdtkadqiltgqrktiknkqkvsknnetfnmslynlkrneetyqdknsl
IE1_HHV6U/435-520                    ...................................n----------------------------------------------------------------------------------------------------------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....KMYPCT.PSPEVPGK..SKYVGTFTENSRQSGDE....QTNPNCVGTASVTDLGGPDNLNSISGLQSCKNMLLERLLDTQCDSVV--EGTEQ-------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------dg....................................................................................................................
IE2_HHV6U/2-109                      ..................................ep---------------AKPSGNNMGSNDERMQDYRPDPMMEESIKEILEESLMCDTSFDDLIIPGLESFGLIIPESSNNIE------SNNVEEGSDGELKTLAEQKCkqGND-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ndviqsamklsglycd......................................................................................................
A0A191S3S2_9BETA/1-729               ....................................MEPNTDCN-SPMLVVGQPSR-TMASTEERQIEYHPDTTVEETIRDILQDSLRCNPSFDNLVFQELDSFDFLDTISSNDIVTANASYSANVEEGASREVKLAAAQSV..STCIQGIIKSVNAAMDQDRSEIEDYLINHAGILTNDRNMLTDLALEQLSQLLNVNLVSSTSAGLISYYETILSGEQLEFFSWCEPRFTVFACDKFDEIVRKVILNCRQCLSNLKNDMNNRLIKCIQNVMNMGNFTNSNEKLTRCATLLIMLGKNKAVTNSTITNKEFYSQINNLKKQLLECKVELIEKNSKIAQTLKKFAVKQLDQMFMSMCDKTFLKIHFNCSNLIEAAKNLGAAILQTIVLCSNEFSAKKFTENRKRFKVTLINMINNACNQIEKLYDVTGIVTVLSTTAIRNGYFTANNHKSSTLFESELHNSSITLSEIDDFNNHGKYSEETSEvsEHISEHDSQSNENNKSN.INLPVSlllsqgKTSEVNSSENEtgmvamSATQDFSTDINLKchenikleRSEqiniSVLSET.CSNEETKMfdVPATQDFIRDMDLKGHE....NTNPER---SEHTNTSVPDEINLP-IDNRFNNIKTHKICQDEMSCVTFEINQTISDPCTLFAEKL-NINNNNQDKGHCSKVSN----VTFQERDE-NREQMLFKNTEPVHLENDAEKRAAEGLVILSDNTNNNnnceienscQLISEMETYGYDTDCSTIYESESDE---TITSCNTDS---------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------tfssdfnslynl..........................................................................................................
Q69515_HHV7J/7-85                    ...............................ykfyy-------------------------------RYHPDTTVEETIRDILQDSLKCNPSFDNTLFQELDSFDFLDSISSNDIATANASYSTNVEEGASSDIKL------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------aagif.................................................................................................................
W8FUA8_9BETA/1-334                   ....................................----------------------------------------------------------------------------------------------------------..--------------MKQEQSDMEDKLIKCAGLLTQQQSMFIGLGLEQLSQLININLLSSASTKYVESYSKMLHGKELDFFNWCEPRFIVFACDKFDGLVKKVASESRNLLLDLRANMNNDIIKAVKDIFSKATVTLDCQKLNQGATMLMMMAHNKEMSNPDISSEDFCEKINTLKQTLLEGKNEIVETNAKNMQILQTFAIKQMNQIFMDGCDKAFLKLNVNCKNLISAAKNLANAILQSIVICSNEFSWQHLKLLRQGFKATMLTMITQACERLESSYDDTGLIKPLAPLQIMEGYINMDKNRQSSICDGNTDPSDSMILDLIDFDDHGRYSEESSI..ESIHEDDDN--------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------k.....................................................................................................................
A0A191S3S2_9BETA/720-974             .......................ssdfnslynlivs----------------------------------------------------------------------------------------------------------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------------.........------------------------------------------------------------------------------------KKRNKAMKRKyNVQIKSSKPKKMKLSK---SENH--ISPDSSFDSDSDS-----------DSDSDSQCdMSFSNTSTENENTLfpKKSKLNNGINFD.DCKSGGFPSVVFTMPIRSVQG.IsNGVRIKFVPTKNWLWFLHKTHKVNIQDM-EIETDENKNGEFTEQASYCFKNHFIAIKNNDEEYKLANVSYTYPKLQKHFIDLDSITQTKNLLVNMIMTNFMEINEVIKTGIEKHYQELKKKFF--------------------------------------------------------------------------------------------------cennnqielssvdtvv......................................................................................................
U90_HHV6Z/1-1078                     ....................................MESAKDTTSTSMFILGKPSGNNMESNEERMQNYHPDPVVEESIKEILEESLKCDVSFESLLFPELEAFDLFIPESSNDIASKNVSYSSNVEEGASDEFKTLVAQSV..GNCIQSIGASVKAAMKQEQSNMEDNLINSAGLLTLHRSMLERLVLEQLGQLININLLSSASSQFVSCYAKMLSGKNLDFFNWCEPRFIVFACDKFDGLVKKIASESRDLLMDLKANMNNQFITALKNIFSKAYVALDSGKLNMVATSLLLMAHNKEMSNPEISNKEFCKQVNLLKQELLESRNEIIENHVKNMKMFQEFANKQMNQIFMDNCDKTFLKIHINCKNLITAAKNIGIAVLQSIVLCSNEFSWQYLKPRRHQFKITMMNMITHACECIETIYDDTGLIKPLTSSDIMEGYIAINKNRESSICDLNIDPSESILLELADFDEHGKYSEESSI..ESIHEDDDNVDYLKYME.VQSPTD......NNIPTPSKNNE......SPTRQKLTNIHEK........DVG....KMYPDT.PSPDVPGK..SKEAKTFIEYSRQIGKE....QTSPNCVCTASVTDLGGPDNFKSITGLESGKHFLIKKLLETQPDSVVVETGSGQQDILAYSPDKRSQTKEWIQEKGSNSKCTETLPGMTFTNSATPVKSHGAIQDTLNPESKLDKEMEAVESLVNLCDGFHDN.........PLISEMITFGYETDHSAPYESESDNNDETDYIADCDSTVRTNNIHMNNTNENTPFSKSLYSPPEVTPSKEDHKTEKIVAVSQKCKSKKRTAKRK.NVPIKPSKSKKIKLDRLPETTNVIVISSESEDEEDGNNIIDKSMLEKTIKSEPNSES.SSESDDCTSEDNYL..HLSDYDKVINNG.HCQSKGFPSPVFTIPIRSMPG.T.HDIRNKFVPKKHWLWFMRKTHKVDNCVIHSSAKMNVKNDSDVTEANHCFINHFVPIKTDDEEYEKENVSYTYSKIQDSKTDLEDITPTKKLITEMVMENFMDLTDIIKHGIAKHCQDLSSKYTVITHTACEKNLNVANSQNLVTAETQIFDPQGTGNNSPILNIINDTTCQNDENRCTEGTSNDNEKCTIRSDCNSDKMEVFKLDGYPSDYDPFEENAQIY......................................................................................................................
Q69514_HHV7J/842-1050                ivkegcnnmelnsctdtdnenmsnfntemstdsipy----------------------------------------------------------------------------------------------------------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..----RSKLINNSdNCENNGFPSVVFTIPIRSIRGvT.RGVRVKIVPKKNCLWFLRKTHKVN-IPDTGMKKD--ENKELTKQASYCFNNHFIPIRSNDEEYRRENVSYIFPKLQENFIEVDSISETKTMVTNIIMDNFMEITEMIKNGINRHYEELKKRYA--------------------------------------------------------------------------------------------------nknvsemnsfileqsvdtqny.................................................................................................
IE1_HHV6U/2-436                      ..................................ep---------------AKPSGNNMGSNDERMQDYRPDPMMEESIKEILEESLMCDTSFDDLIIPGLESFGLIIPESSNNIE------SNNVEEGSDGELKTLAAQSA..GNCIQSIGASVKAAMKQEQSDMEDKLIKCAGLLTQQQSMFIGLGLEQLSQLININLLSSASTKYVESYSKMLHGKELDFFNWCEPRFIVFACDKFDGLVKKVASESRNLLLDLRANMNNDIIKAVKDIFSKATVTLDCQKLNQGATMLMMMAHNKEMSNPDISSKDFCEKINTLKQTLLEGKNEIVETNAKNMQILQTFAIKQMNQIFMDGCDKAFLKLNVNCKNLITAAKNLANTILQSIVICSNEFSWQHLKLLRRGFKVTMLNMITQACECLESDYDDTGLIKPLTPLQIMDGYINMNKNRQSSICDGNTDPSDSMILDLADFDDHGRYSEESSI..ESIHEDDDN--------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------k.....................................................................................................................
IE1_HHV6U/518-941                    ...................................q----------------------------------------------------------------------------------------------------------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------DGSYGN.........TLISEMMMFGYETDHSAPYESESDNNDEIDYIANSDSAARTNNIHMNSTDENTPFSNSICSPPEVTPSKKNVKPKSMTPGS---KPKKRVAKRK.HVSSKSPKNKKIKTDQLPKAADVIVISSESEDEEDGDNIIGNSILIKAIKSESDSES.SSESNDCTSEHKQL..HLSDYDEVTNNG.HCPSYGFPTPVFTIPIRSMQG.T.GGIKSKFIPKKNWIWYMKKTHQVDNCPIHNSENVDAKDDSDGTEAKHCFMNHFVPIKTDDEDYDKNNVSYIYNKIQNSKIDSGDIIPTKKLIIDMVMDNFMDLNDIIKQGITKHCQDLCNKYNVVTPTTCEDDLNMTNSQTFATTATQVFDPPVTGNNSSILNIINDTTSQNDENRCTEGTSNSNEKCTNISDCNSDGTEAFKLDGYPSDYDPFVENAQIY......................................................................................................................
W8FUA8_9BETA/333-418                 ...................................n----------------------------------------------------------------------------------------------------------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....KMYPCT.PSPEVPGK..SKYVGTFTENSRQSGDE....QTNPNCVGTASVTDLGGPDNLNSISGLQSCKNMLLERLLDTQCDSVV--EGTEQ-------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------dg....................................................................................................................
W8FUA8_9BETA/416-839                 ...................................q----------------------------------------------------------------------------------------------------------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------DGSNGN.........PLISEMLMFGYETDHSAPYESESDNNDEIDYIANSDSAARTNNIHMNSTDENTPFSNSICSPPEVTPSKKNVKPKSMTPGS---KPKKRVAKRK.HVSSKSPKQKKIKTDQLPKAADVIVISSESEDEEDGDNIIGNSILIKAIKSESDSES.SSESDDCTSEHKQL..HLSDYDKVTNNG.DCPSKGFPTPVFTIPIRSMQG.A.HGIKSKFIPRKNWIWYMKKTHQVDNCPIHSSENVNAKDDSDGTEAKHCFMNHFVPIKTDDEDYDKDNVSYIYNKIQNSKIDSENVTPNTRLIIDMAMDNFMDLNDIIKQGITKHCQDLCNKYNVVTPTTCEKDLNVTNSQTVATTATQVFDPPVTGNNSSILNIINDTTSQNDENRCTEGTSNSNEKCTNISDCNSDGTEAFKLDGYPSDYDPFVENAQIY......................................................................................................................
W8FQV6_9BETA/1-85                    ....................................-------------------------------------MMEESIQQILEDSLMCDTSFDDLILPGLESFGLIIPESSNNIE------SNNVEEGSNEDLKTLAGKYM..NY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------.------......-----------......-------------........---....------.--------..-----------------....-------------------------------------------------------------------------------------------------------------------------------------.........----------------------------------------------------------------------------------------------.---------------------------------------------------------.--------------..------------.---------------------.-.-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------iicpkienkkkhsfkhvtyn..................................................................................................
#=GC seq_cons                        ..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.....................................................................................................................
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