GenomeNet

Database: Pfam
Entry: HILPDA
LinkDB: HILPDA
Original site: HILPDA 
#=GF ID   HILPDA
#=GF AC   PF15220.8
#=GF DE   Hypoxia-inducible lipid droplet-associated 
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Hetherington K;
#=GF SE   Jackhmmer:Q9Y5L2
#=GF GA   27.00 27.00;
#=GF TC   27.70 37.60;
#=GF NC   24.50 22.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   15930302
#=GF RT   Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker
#=GF RT   for renal cell carcinoma and potential target for molecular
#=GF RT   therapy.
#=GF RA   Togashi A, Katagiri T, Ashida S, Fujioka T, Maruyama O, Wakumoto
#=GF RA   Y, Sakamoto Y, Fujime M, Kawachi Y, Shuin T, Nakamura Y;
#=GF RL   Cancer Res. 2005;65:4817-4826.
#=GF RN   [2]
#=GF RM   20624928
#=GF RT   Hypoxia-inducible protein 2 is a novel lipid droplet protein and
#=GF RT   a specific target gene of hypoxia-inducible factor-1.
#=GF RA   Gimm T, Wiese M, Teschemacher B, Deggerich A, Schodel J, Knaup
#=GF RA   KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Honing S,
#=GF RA   Eckardt KU, Warnecke C;
#=GF RL   FASEB J. 2010;24:4443-4458.
#=GF DR   INTERPRO; IPR026190;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins stimulate intracellular lipid
#=GF CC   accumulation, function as autocrine growth factors and enhance
#=GF CC   cell growth [1-2].
#=GF SQ   52
#=GS A0A287CWM8_ICTTR/1-63     AC A0A287CWM8.1
#=GS F7DI02_CALJA/1-63         AC F7DI02.1
#=GS A0A2I3FYD0_NOMLE/1-63     AC A0A2I3FYD0.1
#=GS A0A4W2DCY9_BOBOX/1-42     AC A0A4W2DCY9.1
#=GS A0A340YLN8_LIPVE/1-63     AC A0A340YLN8.1
#=GS A0A452CDE2_BALAS/1-63     AC A0A452CDE2.1
#=GS A0A2K6K7Y4_RHIBE/1-63     AC A0A2K6K7Y4.1
#=GS A0A0G2JX33_RAT/22-84      AC A0A0G2JX33.1
#=GS A0A671FW55_RHIFE/86-146   AC A0A671FW55.1
#=GS A0A2R8ZR76_PANPA/1-63     AC A0A2R8ZR76.1
#=GS A0A212CKN7_CEREH/102-161  AC A0A212CKN7.1
#=GS A0A1U8CG14_MESAU/1-63     AC A0A1U8CG14.1
#=GS A0A1S3FGI5_DIPOR/1-63     AC A0A1S3FGI5.1
#=GS HLPDA_HUMAN/1-63          AC Q9Y5L2.1
#=GS A0A091E2N4_FUKDA/1-63     AC A0A091E2N4.1
#=GS A0A2Y9K987_ENHLU/1-63     AC A0A2Y9K987.1
#=GS A0A4X2K0G6_VOMUR/1-60     AC A0A4X2K0G6.1
#=GS L8IMV3_9CETA/1-71         AC L8IMV3.1
#=GS G5BH99_HETGA/1-63         AC G5BH99.1
#=GS G1T220_RABIT/1-63         AC G1T220.2
#=GS G7P0L7_MACFA/1-63         AC G7P0L7.1
#=GS A0A5N3XHX6_MUNRE/1-64     AC A0A5N3XHX6.1
#=GS A0A5F8HFC6_MONDO/1-59     AC A0A5F8HFC6.1
#=GS A0A286XJ53_CAVPO/1-63     AC A0A286XJ53.1
#=GS A0A2J8U4M3_PONAB/1-63     AC A0A2J8U4M3.1
#=GS A0A287ATB3_PIG/1-63       AC A0A287ATB3.2
#=GS A0A2K5XU87_MANLE/1-63     AC A0A2K5XU87.1
#=GS A0A1U7TZ58_CARSF/1-63     AC A0A1U7TZ58.1
#=GS A0A2U4AG85_TURTR/1-63     AC A0A2U4AG85.1
#=GS A0A452E205_CAPHI/1-61     AC A0A452E205.1
#=GS A0A2I2YIJ7_GORGO/1-63     AC A0A2I2YIJ7.1
#=GS A0A2Y9T411_PHYMC/1-63     AC A0A2Y9T411.1
#=GS A0A341CVM3_NEOAA/1-63     AC A0A341CVM3.1
#=GS A0A384DBC0_URSMA/1-63     AC A0A384DBC0.1
#=GS A0A3Q7TAF2_VULVU/1-63     AC A0A3Q7TAF2.1
#=GS A0A5F5XHX6_FELCA/90-150   AC A0A5F5XHX6.1
#=GS A0A5F4BVC7_CANLF/6-69     AC A0A5F4BVC7.1
#=GS A0A2Y9PPG5_DELLE/1-63     AC A0A2Y9PPG5.1
#=GS A0A5F4CHW7_CANLF/1-63     AC A0A5F4CHW7.1
#=GS HLPDA_MOUSE/1-63          AC Q9JLS0.1
#=GS A0A1S3WG76_ERIEU/1-63     AC A0A1S3WG76.1
#=GS A0A3Q7WMV8_URSAR/1-63     AC A0A3Q7WMV8.1
#=GS A0A2K5KTS8_CERAT/1-63     AC A0A2K5KTS8.1
#=GS H2QVB8_PANTR/1-63         AC H2QVB8.1
#=GS F6XDF7_HORSE/1-61         AC F6XDF7.2
#=GS A0A0D9RCH4_CHLSB/1-63     AC A0A0D9RCH4.1
#=GS A0A671FWH6_RHIFE/75-135   AC A0A671FWH6.1
#=GS A0A452QTA1_URSAM/1-61     AC A0A452QTA1.1
#=GS A0A2Y9RMV6_TRIMA/1-65     AC A0A2Y9RMV6.1
#=GS A0A2K6NMQ7_RHIRO/1-63     AC A0A2K6NMQ7.1
#=GS A0A3Q1MES7_BOVIN/1-42     AC A0A3Q1MES7.1
#=GS A0A2Y9HYW6_NEOSC/1-63     AC A0A2Y9HYW6.1
A0A287CWM8_ICTTR/1-63                .......MKNMLNLYL.LGVVLTLLSVFVRLMETLGALVESPLPGSTWNTR.GQLTNTESPKGLPD.HQSRGV...................................
F7DI02_CALJA/1-63                    .......MKHVLNLYL.LGVVLTLLSIFVRVMESLEGLREIPSPGTSWTTR.SQLANTEPPKGLPD.HPSRGM...................................
A0A2I3FYD0_NOMLE/1-63                .......MKHLLNLYL.LGVVLTLLSIFVRVMESLESLLESPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSM...................................
A0A4W2DCY9_BOBOX/1-42                .......MKHMLNLYL.LGGVMTLLSIFIGLMESLEACW------------.--------------.------racllgapgpp........................
A0A340YLN8_LIPVE/1-63                .......MRHMLSVYL.LGVVLTLLSIFVRLMESLGVLLESPSPGSSWTTR.GQLANTEXPKSLPD.HPSRGV...................................
A0A452CDE2_BALAS/1-63                .......MKHMLNLYL.LGVVLTLLSIFVRLMESLGGLLESPSPGSSWTTR.GQLANTEXPRGLPD.HPSGGV...................................
A0A2K6K7Y4_RHIBE/1-63                .......MKHVLNLYL.LGVVLTLLSIFVRVMESLEGLLENPLPGTSWTTR.SQLTNTEPTKGLPD.HPSRSM...................................
A0A0G2JX33_RAT/22-84                 .......MKYMLNLYV.LGVMLTLLSIFVRLMESLGGLLENPLPGSSWITR.GHLANTQPPRGLPD.HPSRGV...................................
A0A671FW55_RHIFE/86-146              .......MKHMLNLYL.LGVALALLSIFTRLMESLGGLLETPSPGGSWTTR.DQLASTVPPRAF--.------qnihpe.............................
A0A2R8ZR76_PANPA/1-63                .......MKHVLNLYL.LGVVLTLLSIFVRVMESLEGLLESPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSM...................................
A0A212CKN7_CEREH/102-161             .......MKHMLNLYL.LGGVLTLLSIFIRLMESLEGLLESPSPGSSWATR.DQLANTEPR-----.------afqtihpe...........................
A0A1U8CG14_MESAU/1-63                .......MKYMLNLYL.LGVVLTLLSVFVRLMESLEGLLENPLPGSPWITR.GQLANTEPPKGLPD.HPSRGV...................................
A0A1S3FGI5_DIPOR/1-63                .......MRNMVNLYL.LGVVLTLLSIFVRLMESLESLLTSPLPENSWTTR.GQLANTEPPKGLPD.HPSRGV...................................
HLPDA_HUMAN/1-63                     .......MKHVLNLYL.LGVVLTLLSIFVRVMESLEGLLESPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSM...................................
A0A091E2N4_FUKDA/1-63                .......MKYILNLYL.LGVVLTLLSVFVRLMESLEGLLENPLPGNPWAVR.GHLAHTELPKGLPE.HPSRGV...................................
A0A2Y9K987_ENHLU/1-63                .......MKPVLNLYL.LGVVLTLLSIFVRLMESLGGLLQSPLPGSSWTTR.GQPASTEPXEGVPD.HPSRGV...................................
A0A4X2K0G6_VOMUR/1-60                .......MKHVLNLYM.LGMLLTFLSIFVRLMESLGVLLEGYPFRSHWPSR.GPPASINPPKGLF-.HPS---w..................................
L8IMV3_9CETA/1-71                    .......MKHMLNLYL.LGGVMTLLSIFIGLMESLEACWRACLL-------.--------------.------gapgppevslptqspqgpsrpsiqrgvirppstgy
G5BH99_HETGA/1-63                    .......MKYILSLYL.LGVVLTLLSVFVRLMESLEGLLESPLPVSPWAIR.GHLANTELPKGLPD.HPSRGV...................................
G1T220_RABIT/1-63                    .......MKHVLNLYV.LGVVLALLSIFVRVMESLESLVESPSAGNSWSTR.GQLAGAEPPKGLPD.PPSRGM...................................
G7P0L7_MACFA/1-63                    .......MKHMLNLYL.LGVVLTLLSIFVRVMESLEGLLENPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSM...................................
A0A5N3XHX6_MUNRE/1-64                .......---VFNLYL.LGVVFTLFSI------NLGDLLESPYPGSPWATSiGQLEPTQSPLG-PS.KPS---iqkgvikppstgy......................
A0A5F8HFC6_MONDO/1-59                .......MKHLLSFYL.LGVLLSFLSIFVRLMETLGGLLEG-YPWSHLPSR.IQGTNDNPPKRLPE.ECS---...................................
A0A286XJ53_CAVPO/1-63                .......MKHILNLYL.LGVVLTLLSVFFRLMESVEGLLESPLPGSTWTMR.NHLAHTELPKTLPD.HPSRGV...................................
A0A2J8U4M3_PONAB/1-63                .......MKHVLNLYL.LGVVLTLLSIFVRVMESLEGLLESPSPGTSWTTR.SQLTNTEPTKGLPD.HPSRGM...................................
A0A287ATB3_PIG/1-63                  .......MKQVLQLYL.LGVVLTLLSVFVRLMETLGGLLESPSPGSFWTTR.GQLANTEAPRAF--.------qnihpeec...........................
A0A2K5XU87_MANLE/1-63                .......MKHMLNLYL.LGVVLTLLSIFVRVMESLEGLLENPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSM...................................
A0A1U7TZ58_CARSF/1-63                .......MKPVLNLYL.LGMVLTLLSIFVRLMESLEGLLESPLPGNSWVTR.NQLANTESPKSLPD.HPSRGM...................................
A0A2U4AG85_TURTR/1-63                .......MKHMLNLYL.LGVVLTLLSIFVRLMESLGVLLESPSPGSSWTTR.GQLANTESPTXLPD.HPSRGV...................................
A0A452E205_CAPHI/1-61                .......MKHVLNLYL.LGGVLTLLSIFVRLMESLEGLLESPSPGSSWATR.GQLANTEPPRA---.------fqtihpe............................
A0A2I2YIJ7_GORGO/1-63                .......MKHVLNLYL.LGVVLTLLSIFVRVMESLEGLLESPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSM...................................
A0A2Y9T411_PHYMC/1-63                .......MKHMLNLYL.LGVVLTLLSIFVRLMESLGGLLESPSPGSSWTTR.GQLANTEXPKGLPD.HPSRGV...................................
A0A341CVM3_NEOAA/1-63                .......MKHMLNLYL.LGVVLTLLSIFVRLMESLGVLLESPSPGSSWTTR.GQLANTDSPTXLPD.HPSRGV...................................
A0A384DBC0_URSMA/1-63                .......MKPVLNLYL.LGVVLTLLSIFVRLMESLGGLLESPLPGNSWTTR.GQPASTEPXKGIPD.HPSRGV...................................
A0A3Q7TAF2_VULVU/1-63                .......MKPMLNLYL.LGVVLTLLSIFVRLMESLGGILESPLLGSSWTTR.GHPASAEPXKGIPD.HPSREV...................................
A0A5F5XHX6_FELCA/90-150              .......MKPLLNLYL.LGVVLTLLSIFVRLMESLGGLLESPLPGSSWTTR.SQPASTEPPRA---.------fqtihpe............................
A0A5F4BVC7_CANLF/6-69                khiivgl-----PMYLfLGVVLTLLSVFIGLIESLGCLVESPLPGSSWTTR.GQLPSTEPPS--PG.QP----sseh...............................
A0A2Y9PPG5_DELLE/1-63                .......MKHMLNLYL.LGVVLTLLSIFVRLMESLGVLLESPSPGSSWTTR.GQLANTDXPKSLPD.HPSRGV...................................
A0A5F4CHW7_CANLF/1-63                .......MKPMLNLYL.LGVVLTLLSIFVRLMESLGGILESPLLGSSWTTR.GHTASAEPPRAFQTiHPE---rc.................................
HLPDA_MOUSE/1-63                     .......MKFMLNLYV.LGIMLTLLSIFVRVMESLGGLLESPLPGSSWITR.GQLANTQPPKGLPD.HPSRGV...................................
A0A1S3WG76_ERIEU/1-63                .......MKNVLNLYL.LGVVLTVLSLFVRLMESLGGLLDGPAPGDSWTTR.GQLASAEPPKGLPD.HPSRAV...................................
A0A3Q7WMV8_URSAR/1-63                .......MKPVLNLYL.LGVVLTLLSIFVRLMESLGGLLESPLPGNSWTTR.GQPASTEPXKGVPD.HPSRGV...................................
A0A2K5KTS8_CERAT/1-63                .......MKHMLNLYL.LGVVLTLLSIFVRVMESLEGLLENPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSM...................................
H2QVB8_PANTR/1-63                    .......MKHVLNLYL.LGVVLTLLSIFVRVMESLEGLLESPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSM...................................
F6XDF7_HORSE/1-61                    .......MKHILNLYL.LGVVLTLLSIFVRLMESLEGLLESPSPGSSWTTR.SQLVSTRPPRA---.------fqtihpe............................
A0A0D9RCH4_CHLSB/1-63                .......MKHMLNLYL.LGVVLTLLSIFVRVMESLEGLLENPSPGTSWTTR.SQLANTEPTKGLPD.HPSRSI...................................
A0A671FWH6_RHIFE/75-135              .......MKHMLNLYL.LGVALALLSIFTRLMESLGGLLETPSPGGSWTTR.DQLASTVPPRAF--.------qnihpe.............................
A0A452QTA1_URSAM/1-61                .......MKPVLNLYL.LGVVLTLLSIFVRLMESLGGLLESPLPGNSWTTR.GQPASTEPPRA---.------fqtihpe............................
A0A2Y9RMV6_TRIMA/1-65                .......MRHMLNLYF.LGVVLTLLSIFFGLMESLEALLEGPSTGTSWSTR.GQLASPEPPKGLPD.RPSQ--prgl...............................
A0A2K6NMQ7_RHIRO/1-63                .......MKHVLNLYL.LGVVLTLLSIFVRVMESLEGLLENPLPGTSWTTR.SQLTNTEPTKGLPD.HPSRSM...................................
A0A3Q1MES7_BOVIN/1-42                .......MKHMLNLYL.LGGVMTLLSIFIGLMESLEACW------------.--------------.------racllgapgpp........................
A0A2Y9HYW6_NEOSC/1-63                .......MKPVLNLYL.LGVVLTLLSIFVRLMESLGGILESPLPRSSWTTR.GQPASTEPXEGVPD.NPSRGV...................................
#=GC seq_cons                        .......MKHhLNLYL.LGVVLTLLSIFVRLMESLtGLLESP.PGoSWTTR.uQLAsTEPsKGLPD.HPSRuh...................................
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