GenomeNet

Database: Pfam
Entry: Hepsin-SRCR
LinkDB: Hepsin-SRCR
Original site: Hepsin-SRCR 
#=GF ID   Hepsin-SRCR
#=GF AC   PF09272.12
#=GF DE   Hepsin, SRCR domain
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1p57
#=GF GA   26.60 26.60;
#=GF TC   26.60 26.60;
#=GF NC   26.50 26.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   HPN_(gene)
#=GF CL   CL0550
#=GF RN   [1]
#=GF RM   12962630
#=GF RT   The structure of the extracellular region of human hepsin
#=GF RT   reveals a serine protease domain and a novel scavenger receptor
#=GF RT   cysteine-rich (SRCR) domain. 
#=GF RA   Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K,
#=GF RA   Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA; 
#=GF RL   Structure. 2003;11:1123-1131.
#=GF DR   INTERPRO; IPR015352;
#=GF DR   SCOP; 1p57; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family form an extracellular domain of the
#=GF CC   serine protease hepsin. They are formed primarily by three
#=GF CC   elements of regular secondary structure: a 12-residue alpha
#=GF CC   helix, a twisted five-stranded antiparallel beta sheet, and a
#=GF CC   second, two-stranded, antiparallel sheet. The two beta-sheets
#=GF CC   lie at roughly right angles to each other, with the helix
#=GF CC   nestled between the two, adopting an SRCR fold. The exact
#=GF CC   function of this domain has not been identified, though it
#=GF CC   probably may serve to orient the protease domain or place it in
#=GF CC   the vicinity of its substrate [1].
#=GF SQ   275
#=GS A0A3P8VTL0_CYNSE/53-166   AC A0A3P8VTL0.1
#=GS L5LT73_MYODS/1-106        AC L5LT73.1
#=GS A0A665T266_ECHNA/2-63     AC A0A665T266.1
#=GS A0A452CCQ2_BALAS/61-124   AC A0A452CCQ2.1
#=GS A0A3P9PF00_POERE/59-167   AC A0A3P9PF00.1
#=GS A0A3Q3KU31_9TELE/59-167   AC A0A3Q3KU31.1
#=GS A0A401TMQ1_CHIPU/9-55     AC A0A401TMQ1.1
#=GS A0A2K6GSD4_PROCO/50-159   AC A0A2K6GSD4.1
#=GS A0A2I3M1F4_PAPAN/50-159   AC A0A2I3M1F4.1
#=GS A0A670ILY9_PODMU/50-159   AC A0A670ILY9.1
#=GS A0A4W5K7M4_9TELE/1-71     AC A0A4W5K7M4.1
#=GS G3VR94_SARHA/82-191       AC G3VR94.1
#=GS A0A6I8RNQ5_XENTR/50-159   AC A0A6I8RNQ5.1
#=GS A0A2K6G6U2_PROCO/1-70     AC A0A2K6G6U2.1
#=GS A0A402FUY3_9SAUR/36-144   AC A0A402FUY3.1
#=GS A0A665TN58_ECHNA/28-136   AC A0A665TN58.1
#=GS A1L5C6_BOVIN/50-159       AC A1L5C6.1
#=GS A0A4W4H1V0_ELEEL/41-151   AC A0A4W4H1V0.1
#=GS A0A484H3F3_SOUCH/119-182  AC A0A484H3F3.1
#=GS A0A3Q7UVE8_URSAR/50-159   AC A0A3Q7UVE8.1
#=GS A0A5F4DMZ2_CANLF/2-67     AC A0A5F4DMZ2.1
#=GS A0A2K5E8T4_AOTNA/50-159   AC A0A2K5E8T4.1
#=GS A0A3P8VYZ5_CYNSE/111-219  AC A0A3P8VYZ5.1
#=GS A0A452FVF6_CAPHI/50-159   AC A0A452FVF6.1
#=GS A0A2K6PK87_RHIRO/2-67     AC A0A2K6PK87.1
#=GS M3WAE4_FELCA/52-161       AC M3WAE4.3
#=GS M0QZ63_HUMAN/2-67         AC M0QZ63.1
#=GS A0A667YAR7_9TELE/71-162   AC A0A667YAR7.1
#=GS A0A6I8RUX2_XENTR/1-110    AC A0A6I8RUX2.1
#=GS A0A2J8RR60_PONAB/50-159   AC A0A2J8RR60.1
#=GS A0A5C6MDC7_9TELE/4-68     AC A0A5C6MDC7.1
#=GS A0A673X7P6_SALTR/57-163   AC A0A673X7P6.1
#=GS A0A5F5PU88_HORSE/50-159   AC A0A5F5PU88.1
#=GS G3NQX2_GASAC/52-160       AC G3NQX2.1
#=GS A0A5F8GRM9_MONDO/1-68     AC A0A5F8GRM9.1
#=GS A0A673XFS3_SALTR/63-165   AC A0A673XFS3.1
#=GS A0A340YDF4_LIPVE/50-159   AC A0A340YDF4.1
#=GS A0A3Q2LMD1_HORSE/139-248  AC A0A3Q2LMD1.1
#=GS A0A341AJA3_NEOAA/50-159   AC A0A341AJA3.1
#=GS A0A5G2QCY8_PIG/2-69       AC A0A5G2QCY8.1
#=GS A0A384DU36_URSMA/50-159   AC A0A384DU36.1
#=GS A0A4W2EJN9_BOBOX/69-135   AC A0A4W2EJN9.1
#=GS A0A0P7WBQ5_SCLFO/5-91     AC A0A0P7WBQ5.1
#=GS E9Q5P0_MOUSE/78-187       AC E9Q5P0.1
#=GS G5BXK2_HETGA/49-158       AC G5BXK2.1
#=GS A0A091DMP9_FUKDA/76-185   AC A0A091DMP9.1
#=GS A0A667XKU7_9TELE/3-64     AC A0A667XKU7.1
#=GS K7F422_PELSI/50-159       AC K7F422.1
#=GS A0A5F9CCM9_RABIT/24-133   AC A0A5F9CCM9.1
#=GS A0A2I3GLS7_NOMLE/2-67     AC A0A2I3GLS7.1
#=GS A0A5E4AF02_MARMO/339-448  AC A0A5E4AF02.1
#=GS A0A3P9AKH4_ESOLU/58-169   AC A0A3P9AKH4.2
#=GS A0A498MLH0_LABRO/37-144   AC A0A498MLH0.1
#=GS G1RJH3_NOMLE/50-159       AC G1RJH3.3
#=GS A0A0D9QX09_CHLSB/50-159   AC A0A0D9QX09.1
#=GS A0A672ZWJ1_9TELE/53-148   AC A0A672ZWJ1.1
#=GS A0A3Q7VQG8_URSAR/36-145   AC A0A3Q7VQG8.1
#=GS A0A2K5MA41_CERAT/50-159   AC A0A2K5MA41.1
#=GS A0A2K5SJV5_CEBCA/50-159   AC A0A2K5SJV5.1
#=GS F7B8K3_HORSE/60-169       AC F7B8K3.2
#=GS G1NYX6_MYOLU/50-159       AC G1NYX6.1
#=GS HEPS_HUMAN/50-159         AC P05981.1
#=GS HEPS_HUMAN/50-159         DR PDB; 3T2N B; 50-158;
#=GS HEPS_HUMAN/50-159         DR PDB; 1O5F L; 5-114;
#=GS HEPS_HUMAN/50-159         DR PDB; 1Z8G A; 50-159;
#=GS HEPS_HUMAN/50-159         DR PDB; 5CE1 A; 50-158;
#=GS HEPS_HUMAN/50-159         DR PDB; 1O5E L; 5-114;
#=GS HEPS_HUMAN/50-159         DR PDB; 1P57 A; 5-114;
#=GS HEPS_HUMAN/50-159         DR PDB; 3T2N A; 50-159;
#=GS A0A5F9C7U9_RABIT/2-67     AC A0A5F9C7U9.1
#=GS A0A5C6MF57_9TELE/4-68     AC A0A5C6MF57.1
#=GS A0A401QAF0_SCYTO/32-140   AC A0A401QAF0.1
#=GS A0A2K5YAF7_MANLE/2-67     AC A0A2K5YAF7.1
#=GS A0A060XRE8_ONCMY/50-161   AC A0A060XRE8.1
#=GS A0A3P9AKF6_ESOLU/26-137   AC A0A3P9AKF6.2
#=GS A0A1S3N800_SALSA/50-161   AC A0A1S3N800.1
#=GS A0A667XVS2_9TELE/71-162   AC A0A667XVS2.1
#=GS A0A2K5YAF9_MANLE/6-71     AC A0A2K5YAF9.1
#=GS A0A1U7R8J9_MESAU/70-179   AC A0A1U7R8J9.1
#=GS A0A2U9AZ70_SCOMX/6-114    AC A0A2U9AZ70.1
#=GS A0A2I4C7H1_9TELE/59-168   AC A0A2I4C7H1.1
#=GS A0A5N4DV80_CAMDR/264-382  AC A0A5N4DV80.1
#=GS A0A3P9BGH5_9CICH/57-151   AC A0A3P9BGH5.1
#=GS A0A2Y9I4N6_NEOSC/50-159   AC A0A2Y9I4N6.1
#=GS A0A3Q2WPB2_HAPBU/59-167   AC A0A3Q2WPB2.1
#=GS A0A2K5WUM0_MACFA/5-67     AC A0A2K5WUM0.1
#=GS G1K3I0_XENTR/17-126       AC G1K3I0.2
#=GS H2LNJ0_ORYLA/59-167       AC H2LNJ0.2
#=GS A0A6I8R3W0_XENTR/50-159   AC A0A6I8R3W0.1
#=GS A0A2I2ZQD6_GORGO/3-67     AC A0A2I2ZQD6.1
#=GS F6XEJ3_MACMU/104-213      AC F6XEJ3.3
#=GS A8DZG9_DANRE/53-160       AC A8DZG9.2
#=GS A0A5F4DAJ9_CANLF/48-156   AC A0A5F4DAJ9.1
#=GS W5LR38_ASTMX/48-97        AC W5LR38.2
#=GS A0A2K6S0I1_SAIBB/50-159   AC A0A2K6S0I1.1
#=GS A0A5F9DGX7_RABIT/50-159   AC A0A5F9DGX7.1
#=GS A0A3Q3RFC4_9TELE/59-167   AC A0A3Q3RFC4.1
#=GS A0A3Q7TW36_URSAR/50-159   AC A0A3Q7TW36.1
#=GS A0A2K5JWD8_COLAP/2-67     AC A0A2K5JWD8.1
#=GS A0A4W4H152_ELEEL/50-157   AC A0A4W4H152.1
#=GS A0A673Z656_SALTR/50-161   AC A0A673Z656.1
#=GS A0A1U7UDG9_CARSF/50-159   AC A0A1U7UDG9.1
#=GS A0A2U3ZXX1_ODORO/50-159   AC A0A2U3ZXX1.1
#=GS A0A672ZXB3_9TELE/54-162   AC A0A672ZXB3.1
#=GS HEPS_MOUSE/69-178         AC O35453.3
#=GS A0A452QJK1_URSAM/50-159   AC A0A452QJK1.1
#=GS A0A2U3X4U0_ODORO/50-159   AC A0A2U3X4U0.1
#=GS A0A5G2R148_PIG/82-191     AC A0A5G2R148.1
#=GS A0A060ZDW1_ONCMY/60-171   AC A0A060ZDW1.1
#=GS A0A3Q4GTS9_NEOBR/59-167   AC A0A3Q4GTS9.1
#=GS A0A5C6MER7_9TELE/4-68     AC A0A5C6MER7.1
#=GS A0A0A0MUQ9_PAPAN/50-159   AC A0A0A0MUQ9.1
#=GS A0A1U8DJM5_ALLSI/59-172   AC A0A1U8DJM5.1
#=GS A0A3Q3H102_KRYMA/59-167   AC A0A3Q3H102.1
#=GS A0A2I3LP24_PAPAN/2-67     AC A0A2I3LP24.1
#=GS A0A3Q7SSN1_VULVU/50-159   AC A0A3Q7SSN1.1
#=GS A0A672ZX50_9TELE/2-63     AC A0A672ZX50.1
#=GS A0A3Q1EHX8_9TELE/59-167   AC A0A3Q1EHX8.1
#=GS A0A5G2QH13_PIG/50-159     AC A0A5G2QH13.1
#=GS A0A4W2E3R0_BOBOX/88-196   AC A0A4W2E3R0.1
#=GS A0A5C6PIB3_9TELE/4-74     AC A0A5C6PIB3.1
#=GS F6XEI3_MACMU/50-159       AC F6XEI3.2
#=GS H3DP30_TETNG/49-157       AC H3DP30.1
#=GS A0A5C6PLF0_9TELE/111-214  AC A0A5C6PLF0.1
#=GS A0A6G0IAN7_LARCR/48-156   AC A0A6G0IAN7.1
#=GS A0A2Y9E802_TRIMA/50-159   AC A0A2Y9E802.1
#=GS A0A2K6GSF6_PROCO/8-116    AC A0A2K6GSF6.1
#=GS A0A2K6JWA7_RHIBE/94-202   AC A0A2K6JWA7.1
#=GS A0A437CIG0_ORYJA/116-224  AC A0A437CIG0.1
#=GS L5K232_PTEAL/127-236      AC L5K232.1
#=GS H0W1M7_CAVPO/67-175       AC H0W1M7.2
#=GS A0A6J3QF44_TURTR/50-159   AC A0A6J3QF44.1
#=GS A0A1S3FYR3_DIPOR/90-199   AC A0A1S3FYR3.1
#=GS A0A5F5PTD7_HORSE/2-67     AC A0A5F5PTD7.1
#=GS A0A4W5P8J5_9TELE/50-161   AC A0A4W5P8J5.1
#=GS A0A0G2KB31_RAT/49-158     AC A0A0G2KB31.1
#=GS U3B7D1_CALJA/50-159       AC U3B7D1.1
#=GS A0A2K6S0K0_SAIBB/5-68     AC A0A2K6S0K0.1
#=GS A0A3Q1AVF9_AMPOC/59-167   AC A0A3Q1AVF9.1
#=GS A0A341AKK7_NEOAA/50-159   AC A0A341AKK7.1
#=GS A0A2Y9L3Z3_ENHLU/50-159   AC A0A2Y9L3Z3.1
#=GS A0A5C6MKJ0_9TELE/26-118   AC A0A5C6MKJ0.1
#=GS G1L013_AILME/50-159       AC G1L013.1
#=GS A0A5C6MIN9_9TELE/3-62     AC A0A5C6MIN9.1
#=GS A0A5F4DET1_CANLF/19-128   AC A0A5F4DET1.1
#=GS A0A0U1RNM3_MOUSE/49-137   AC A0A0U1RNM3.1
#=GS L8Y2T7_TUPCH/1044-1153    AC L8Y2T7.1
#=GS A0A5C6MDE6_9TELE/11-67    AC A0A5C6MDE6.1
#=GS A0A2K5E8U9_AOTNA/2-67     AC A0A2K5E8U9.1
#=GS S9Y1X1_CAMFR/1015-1063    AC S9Y1X1.1
#=GS A0A3N0Y5Q4_ANAGA/27-134   AC A0A3N0Y5Q4.1
#=GS A0A3P8VTG8_CYNSE/59-167   AC A0A3P8VTG8.1
#=GS A0A2K6G6U9_PROCO/2-72     AC A0A2K6G6U9.1
#=GS A0A5F9DJE5_RABIT/212-321  AC A0A5F9DJE5.1
#=GS A0A5F9DI73_RABIT/50-159   AC A0A5F9DI73.1
#=GS A0A452FW09_CAPHI/39-146   AC A0A452FW09.1
#=GS A0A1S3G0V5_DIPOR/90-199   AC A0A1S3G0V5.1
#=GS A0A2K6G6W3_PROCO/50-159   AC A0A2K6G6W3.1
#=GS A0A3Q3EL54_9LABR/59-167   AC A0A3Q3EL54.1
#=GS A0A1U8CCT8_MESAU/50-159   AC A0A1U8CCT8.1
#=GS A0A5J5MXE7_MUNRE/44-153   AC A0A5J5MXE7.1
#=GS A0A455AQ14_PHYMC/50-159   AC A0A455AQ14.1
#=GS A0A2K5MA32_CERAT/50-159   AC A0A2K5MA32.1
#=GS A0A2I2ZEG1_GORGO/50-159   AC A0A2I2ZEG1.1
#=GS H9GPR9_ANOCA/50-159       AC H9GPR9.2
#=GS A0A287AX79_PIG/36-145     AC A0A287AX79.1
#=GS L8IIJ4_9CETA/50-159       AC L8IIJ4.1
#=GS A0A452FVL9_CAPHI/50-159   AC A0A452FVL9.1
#=GS A0A315WDD0_GAMAF/59-167   AC A0A315WDD0.1
#=GS A0A2R9AW61_PANPA/1-59     AC A0A2R9AW61.1
#=GS H0WMD5_OTOGA/50-159       AC H0WMD5.1
#=GS A0A3Q1JW72_ANATE/47-156   AC A0A3Q1JW72.1
#=GS A0A4W2CDM0_BOBOX/2-69     AC A0A4W2CDM0.1
#=GS A0A2K6JWB5_RHIBE/5-67     AC A0A2K6JWB5.1
#=GS A0A2K6S0G5_SAIBB/50-159   AC A0A2K6S0G5.1
#=GS A0A5C6PMN3_9TELE/14-112   AC A0A5C6PMN3.1
#=GS A0A2K5JWK7_COLAP/50-159   AC A0A2K5JWK7.1
#=GS H3B0M0_LATCH/50-157       AC H3B0M0.1
#=GS G3QQU1_GORGO/2-67         AC G3QQU1.2
#=GS A0A5N5KR55_PANHP/51-159   AC A0A5N5KR55.1
#=GS A0A2I2UDC4_FELCA/204-313  AC A0A2I2UDC4.1
#=GS A0A2K5YAE7_MANLE/50-159   AC A0A2K5YAE7.1
#=GS A0A1S3AR63_ERIEU/50-159   AC A0A1S3AR63.1
#=GS A0A2Y9PFM1_DELLE/232-341  AC A0A2Y9PFM1.1
#=GS A0A672FN44_SALFA/53-161   AC A0A672FN44.1
#=GS A0A4X2M2W4_VOMUR/50-159   AC A0A4X2M2W4.1
#=GS A0A4U1F9N9_MONMO/191-299  AC A0A4U1F9N9.1
#=GS I3MY60_ICTTR/50-159       AC I3MY60.2
#=GS F6U6E9_XENTR/50-159       AC F6U6E9.3
#=GS E2RKP5_CANLF/120-149      AC E2RKP5.3
#=GS W5M6U1_LEPOC/50-159       AC W5M6U1.1
#=GS S7P5D0_MYOBR/239-348      AC S7P5D0.1
#=GS A0A2I3LWL5_PAPAN/1-59     AC A0A2I3LWL5.1
#=GS A0A6I8N3E7_ORNAN/1-64     AC A0A6I8N3E7.1
#=GS M3Y743_MUSPF/59-168       AC M3Y743.1
#=GS A0A087YLX3_POEFO/59-167   AC A0A087YLX3.2
#=GS A0A3Q4AVA8_MOLML/67-175   AC A0A3Q4AVA8.1
#=GS A0A6A5EED1_PERFL/52-160   AC A0A6A5EED1.1
#=GS A0A553PYL9_9TELE/51-158   AC A0A553PYL9.1
#=GS A0A556TLN0_BAGYA/27-92    AC A0A556TLN0.1
#=GS A0A667XSX7_9TELE/72-179   AC A0A667XSX7.1
#=GS A0A484H3F3_SOUCH/50-100   AC A0A484H3F3.1
#=GS A0A673Z634_SALTR/50-161   AC A0A673Z634.1
#=GS A0A2R9APB7_PANPA/2-67     AC A0A2R9APB7.1
#=GS A0A2K5MA30_CERAT/2-67     AC A0A2K5MA30.1
#=GS A0A673V867_SURSU/36-145   AC A0A673V867.1
#=GS A0A2K5JWM2_COLAP/5-67     AC A0A2K5JWM2.1
#=GS A0A3P8TKW7_AMPPE/59-167   AC A0A3P8TKW7.1
#=GS M0R244_HUMAN/50-80        AC M0R244.1
#=GS A0A2K5SJV2_CEBCA/2-67     AC A0A2K5SJV2.1
#=GS A0A2K5SJW7_CEBCA/50-159   AC A0A2K5SJW7.1
#=GS A0A3Q1M1P8_BOVIN/36-145   AC A0A3Q1M1P8.1
#=GS A0A2K6CZS5_MACNE/2-67     AC A0A2K6CZS5.1
#=GS A0A2Y9I2V0_NEOSC/50-159   AC A0A2Y9I2V0.1
#=GS A0A2K6CZR4_MACNE/50-159   AC A0A2K6CZR4.1
#=GS A0A2K5WUU5_MACFA/104-213  AC A0A2K5WUU5.1
#=GS A0A2K5WUW2_MACFA/2-67     AC A0A2K5WUW2.1
#=GS A0A2K6CZS4_MACNE/5-67     AC A0A2K6CZS4.1
#=GS A0A5E4AEQ6_MARMO/339-448  AC A0A5E4AEQ6.1
#=GS A0A4W6EEL3_LATCA/59-167   AC A0A4W6EEL3.1
#=GS G3UWE8_MOUSE/49-158       AC G3UWE8.1
#=GS A0A2I3T2P1_PANTR/5-67     AC A0A2I3T2P1.1
#=GS G1U4B0_RABIT/50-159       AC G1U4B0.3
#=GS A0A3Q2EIU9_CYPVA/42-150   AC A0A3Q2EIU9.1
#=GS A0A2K6S0J4_SAIBB/2-67     AC A0A2K6S0J4.1
#=GS A0A2K6GSC6_PROCO/64-173   AC A0A2K6GSC6.1
#=GS A0A5A9N0P5_9TELE/50-157   AC A0A5A9N0P5.1
#=GS A0A2R9AW56_PANPA/50-159   AC A0A2R9AW56.1
#=GS A0A5C6MGS1_9TELE/30-95    AC A0A5C6MGS1.1
#=GS A0A337SRE6_FELCA/2-67     AC A0A337SRE6.1
#=GS G3IBD2_CRIGR/1073-1182    AC G3IBD2.1
#=GS A0A2J8QH94_PANTR/50-159   AC A0A2J8QH94.1
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HEPS_HUMAN/50-159                    ......................p-LYPVQVS...S...ADARLMVFDKTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........LTH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...HT.Q...R...L..L....E.V...I....S.V.C.D.CPR.G.RFLA....AICQ.DCGRRKLP.......................
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A0A673X7L2_SALTR/50-161              ......................g-LYDVQVN...SnpsSDLRLRVFDSAERRWRHLCSSE.ANQLLANISCEEMGFVS.M.........VNY.......SVSSI..P.EGSND.-REE.FF..CVK....E.K..E.L..T...YG.K...K...I..K....E.S...L....Y.P.C.D.CET.G.QVLS....LLCQ.DCGRRSLT.......................
A0A2I4C7H6_9TELE/121-230             ......................g-LYDVQVN...S...PDQRLRVFDSAQRRWRQVCSSP.SNELLASISCEEVGFVS.L.........VNY.......SVALV..P.EASGD.GGE-.FF..CIK....QdE..Q.L..S...YG.K...K...I..K....D.L...F....I.P.C.D.CDS.R.EVLT....LSCQ.DCGRRSF-t......................
A0A671EJM6_RHIFE/108-217             ......................p-LYPVQVS...P...ADARLTVFDETEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........LAH.......SELDV..R.TAGAN.STSG.FF..CVD....E.G..R.L..P...YA.Q...R...L..L....E.V...I....S.V.C.D.CPR.G.RFLA....TICQ.DCGRRKT-p......................
A0A673UWP7_SURSU/2-67                ....................aek---EVQVS...P...ADARLMVFDDTEGTWRLLCSSR.SNARVAGLGCEDMGFLR.R.........---.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....-.-.-.-.---.-.----....----.--------nrvlsrwrvfagavaqa......
A0A5F4BUZ4_CANLF/221-276             ......................p-LYPVQAS...P...ADGRLMVFDDTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.-.........---.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....-.-.-.-.---.-.----....----.--------yrrpgwgs...............
M4A361_XIPMA/59-167                  ......................g-LYDVQVN...S...PDQHLRVFDSAQRRWRQVCSSS.TNELLASISCEEVGFVS.V.........VNY.......SVVSV..P.EASGD.VGE-.FF..CVR....Q.E..E.L..S...YG.K...K...I..K....D.S...L....Y.P.C.A.CES.R.EVLT....LLCQ.DCGRRSF-a......................
A0A2K5MA35_CERAT/4-69                .....................ke--FKLQVS...S...ADARLMVFDKTEGTWRLLCSSR.SNTRVAGLSCEEMGFLR.R.........---.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....-.-.-.-.---.-.----....----.--------nrvlsrwrvfagavaqa......
A0A2F0AYQ2_ESCRO/68-129              ......................p-LYPVQVG...P...ADARLTVFDQTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.K.........LP-.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....-.-.-.-.---.-.----....----.--------vdrivggqdts............
A0A671EJT0_RHIFE/2-67                ....................aek---EVQVS...P...ADARLTVFDETEGTWRLLCSSR.SNARVAGLSCEEMGFLR.R.........---.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....-.-.-.-.---.-.----....----.--------nrvlsrwrvfagavaqa......
A0A673UWC2_SURSU/107-216             ......................p-LYPVQVS...P...ADARLMVFDDTEGTWRLLCSSR.SNARVAGLGCEDMGFLR.A.........LGH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...LA.R...R...L..L....E.V...I....S.V.C.D.CPR.G.HFLA....TVCQ.DCGRRKLP.......................
W5LR38_ASTMX/94-140                  ......................v--------...-...----------------------.-----------------.-.........---.......-----..-.-----.-SHE.FF..CVK....E.S..E.L..T...YG.K...K...I..S....T.A...L....Y.P.C.K.CEK.G.QVVE....VLCQ.ECGRRMLP.......................
A0A4X2M8M5_VOMUR/2-74                ....................aek---EIQVS...P...TDLRLTVFDGTEGTWRLLCSSR.ANSRVASLSCEEMGFIR.R.........N--.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....-.-.-.-.---.-.----....----.--------rvvsrwrvfagavaqastqglql
A0A0G2K7B4_RAT/9-118                 ....................crp---AVQLS...P...GDSRLLVLDKTEGTWRLLCSSR.SNARVAGLGCEEMGFLR.A.........LAH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..G.L..P...LA.Q...R...L..L....D.V...I....S.V.C.D.CPR.G.RFLT....ATCQ.DCGRRKLP.......................
A0A2I4C7H4_9TELE/121-230             ......................g-LYDVQVN...S...PDQRLRVFDSAQRRWRQVCSSP.SNELLASISCEEVGFVS.L.........VNY.......SVALV..P.EASGD.GGE-.FF..CIK....QdE..Q.L..S...YG.K...K...I..K....D.L...F....I.P.C.D.CDS.R.EVLT....LSCQ.DCGRRSF-t......................
G3TA31_LOXAF/34-136                  ......................f-LYLVQVS...P...GDSPLMLFDETGGTWWLLCSLC.SNARVARLSCKEMGFLR.A.........LAH.......SELD-..-.---GD.GTLG.F-..CID....K.G..R.L..S...HV.R...S...L..L....E.V...-....T.L.C.D.CPR.G.YFLA....TICQ.DCGCRKLP.......................
A0A286Y022_CAVPO/49-158              ......................l-LYPVQVS...P...VDARLTVFDKTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........MAH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...QA.H...R...L..L....E.V...I....S.V.C.D.CPR.G.RFLA....TICQ.DCGRRKLP.......................
F1LS97_RAT/9-118                     ....................crp---AVQLS...P...GDSRLLVLDKTEGTWRLLCSSR.SNARVAGLGCEEMGFLR.A.........LAH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..G.L..P...LA.Q...R...L..L....D.V...I....S.V.C.D.CPR.G.RFLT....ATCQ.DCGRRKLP.......................
A0A5J5D9Z0_9PERO/159-280             ......................g-LYDVQVN...S...ADQRLRVFDSAQRRWRQVCSSS.DNELLASISCEEVGFIS.V.........VNY.......SVTSV..P.EASGD.GGE-.FF..CVR....Q.Q..E.L..S...YG.K...K...I..K....D.S...L....F.P.C.D.CES.R.EVLT....LLCQ.V-------yldhklpllysadcgrrsfa...
A0A643CH58_BALPH/53-85               ..............vtvllrsdq--------...-...----------------------.-----------------.-.........---.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....E.P.L.D.CPR.G.RFLA....TICQ.DCGHRKLP.......................
A0A212DC46_CEREH/50-159              ......................p-LYPVQVG...P...ADARLTVFDQTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........LDY.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...HA.R...R...L..L....E.V...L....S.V.C.D.CPR.G.RFLA....TSCQ.DCGHRKLP.......................
F6XQG8_MONDO/44-153                  ......................v-LYPVQVS...P...ADMRLTVFDGTEGTWRLLCSSR.ANSRVASLSCEEMGFIR.S.........LTH.......SELDV..R.VFGTN.GTSG.YF..CVD....E.E..R.L..P...YA.R...R...L..S....E.V...I....S.V.C.D.CPR.G.LFLA....TLCQ.DCGRRKLP.......................
A0A669F3D0_ORENI/34-142              .....................eq--YDVQVN...S...PDQHLRVFDSTHRRWRQVCSSP.ADELLASISCEEVGFVS.V.........VNY.......SVTAV..S.EASGD.-AGD.FF..CVR....Q.E..E.L..S...YG.K...K...I..K....D.S...L....Y.P.C.D.CES.R.EVLT....LLCQ.DCGRRSF-a......................
W5P3L7_SHEEP/50-159                  ......................p-LYPAKVG...P...ADARLTVFDQTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........LDF.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...HA.R...R...L..L....E.V...L....S.V.C.D.CPR.G.RFLA....TSCQ.DCGHRKLP.......................
I3L6R5_PIG/50-159                    ......................p-LYPVQVG...P...GDSRLTVFDETEGTWRLLCSSR.SNARVAGLSCEEMGFLR.S.........LTH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...QA.R...R...L..L....E.V...L....S.V.C.D.CPR.G.HFLA....TTCQ.DCGHRKLP.......................
A0A2Y9PHA2_DELLE/50-159              ......................p-LYPVQVG...P...ADARLTVFDQTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........LAH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...HA.R...R...L..L....E.V...L....S.V.C.D.CPR.G.RFLA....TICQ.DCGHRKLP.......................
F6TCQ7_CALJA/2-67                    ....................aqk---EVQVS...P...ADARLTVFDKTEGTWRLLCSSR.SNARVAGLSCEEMGFIR.R.........---.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....-.-.-.-.---.-.----....----.--------nrvlsrwrvfagavaqa......
A0A3Q2HYH0_HORSE/139-248             ......................a-LYPVQVS...P...ADARLTVFDETEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........LEH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...HA.R...R...L..L....E.V...I....S.V.C.D.CPR.G.HFLT....ALCQ.DCGHRKLP.......................
A0A3P9BGU8_9CICH/58-166              ....................lht---FVQVN...S...PDQHLRVFDSTHRRWRQVCSSP.VDELLASISCEEVGFVS.V.........VNY.......SVTAV..S.EASSD.-AGD.FF..CVR....Q.E..E.L..S...YG.K...K...I..K....D.S...L....Y.P.C.D.CES.R.EVLT....LLCQ.DCGRRSF-a......................
A0A5C6MH86_9TELE/26-118              ...................cnka--------...-...--ARISLFDSTHKRWRQVCSSS.ANEFLASISCEEVGFVS.V.........VNH.......SVASV..P.EASRD.GGH-.--..CP-....-.-..-.-..P...FA.-...-...L..F....F.H...L....S.S.C.D.CES.R.EVLT....LLCQ.DCGRRSF-a......................
A0A1S3RXJ7_SALSA/50-161              ......................g-LYDVQVN...SnpsSDLRLRVFDSAERRWRHLCSSE.ANQLLANISCEEMGFVS.V.........VNY.......SVSSI..P.EGSND.-REE.FF..CVK....E.K..E.L..T...YG.K...K...I..K....E.S...L....Y.P.C.D.CET.G.QVLS....LLCQ.DCGRRSLT.......................
HEPS_PONAB/50-159                    ......................p-LYPVQVS...S...ADARLMVFDKTEGTWRLLCSSR.SNARVAGLSCVEMGFLR.A.........LTH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...HT.Q...R...L..L....E.V...I....S.V.C.D.CPR.G.RFLA....TICQ.DCGRRKLP.......................
A0A4U5V2Q9_COLLU/59-167              ......................g-LYDVQVN...S...ADQRLRVFDTTQRRWRQVCSSS.SNELLASISCEEVGFVS.V.........VNY.......SVISV..P.EASGD.GGE-.FF..CVR....Q.E..E.L..S...FG.K...K...I..K....D.S...L....F.P.C.D.CES.R.EVLT....LLCQ.DCGRRSF-a......................
I3JJX2_ORENI/59-167                  .....................eq--YDVQVN...S...PDQHLRVFDSTHRRWRQVCSSP.ADELLASISCEEVGFVS.V.........VNY.......SVTAV..S.EASGD.-AGD.FF..CVR....Q.E..E.L..S...YG.K...K...I..K....D.S...L....Y.P.C.D.CES.R.EVLT....LLCQ.DCGRRSF-a......................
A0A4X2LYF1_VOMUR/50-159              ......................v-LYPVQVS...P...TDLRLTVFDGTEGTWRLLCSSR.ANSRVASLSCEEMGFIR.S.........LTH.......MELDI..R.AVGTN.GTSG.YF..CVD....E.E..R.L..P...YS.R...R...L..S....E.V...I....S.V.C.D.CPR.G.LFLA....TLCQ.DCGRRKLP.......................
A0A5F4CRS0_CANLF/221-330             ......................p-LYPVQAS...P...ADGRLMVFDDTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........LGH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...LA.R...R...L..L....E.V...I....S.V.C.D.CPR.G.RFLA....TVCQ.DCGRRKLP.......................
A0A484DC43_PERFV/59-167              ......................g-LYDVQVN...S...ADQRLRVFDSAQRRWRQVCSSS.ANELLASISCEEVGFIS.V.........VNY.......SVTSV..P.EASGD.GGE-.FF..CVR....Q.Q..E.L..S...YG.K...K...I..K....D.S...L....F.P.C.D.CES.R.EVLT....LLCQ.DCGRRSF-a......................
A0A2I3S6Y0_PANTR/2-67                ....................aqk---EVQVS...S...ADARLMVFDKTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.R.........---.......-----..-.-----.----.--..---....-.-..-.-..-...--.-...-...-..-....-.-...-....-.-.-.-.---.-.----....----.--------nrvlsrwrvfagavaqa......
A0A2K6PK70_RHIRO/50-159              ......................p-LYPVQVS...S...ADSRLMVFDKTEGTWRLLCSSR.SNTRVAGLSCEEMGFLR.A.........LTH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...HT.Q...R...L..L....E.V...I....S.V.C.D.CPR.G.RFLA....TICQ.DCGRRKLP.......................
HEPS_RAT/49-158                      ......................p-LYQVQLS...P...GDSRLLVLDKTEGTWRLLCSSR.SNARVAGLGCEEMGFLR.A.........LAH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..G.L..P...LA.Q...R...L..L....D.V...I....S.V.C.D.CPR.G.RFLT....ATCQ.DCGRRKLP.......................
A0A1L8FHT6_XENLA/50-159              ......................n-LYVVQVN...L...PDHRLSVYDEKEKVWRLVCSSF.SNPEVATLSCEEMGFIR.S.........VSH.......QELRV..E.TSGTN.GTSG.YY..CVR....E.P..Q.I..S...SG.K...R...L..V....D.I...L....T.V.C.E.CPS.S.KFLS....VQCQ.DCGRRKLA.......................
F6U6G0_XENTR/2-111                   .....................la--LPVQVN...L...PDHRLSVYDEKEKVWRLVCSSF.SNPEVATLSCEEMGFIR.S.........VSH.......QELRV..E.TAGTN.GTSG.YY..CVH....E.S..Q.I..N...SA.K...R...L..L....D.I...L....T.V.C.E.CPS.G.RFLS....VQCQ.DCGRRKLA.......................
A0A151MNY5_ALLMI/57-166              ......................a-LYGVQVS...P...ADLRLTVFDEAEGRWRLVCSSP.ANALVAALSCEEMGFVR.S.........LWH.......SELDV..E.RAGAN.GTSG.FF..CVD....E.A..R.L..P...LA.S...G...L..A....E.V...V....T.A.C.E.CPS.G.RFVA....TLCQ.ECGRRKLP.......................
A0A2I3GLB7_NOMLE/50-159              ......................p-LYPVQVS...S...ADARLMVFDKTEGTWRLLCSSR.SNARVAGLSCEEMGFLR.A.........LTH.......SELDV..R.TAGAN.GTSG.FF..CVD....E.G..R.L..P...HT.Q...R...L..L....E.V...I....S.V.C.D.CPR.G.RFLA....TICQ.DCGRRKLP.......................
#=GC SS_cons                         ......................S-S-SEEE-...T...TT-BEEEEETTTTEEEEEB--T.THHHHHHHHHHHTT-S-.E.........EEE.......EEEEH..H.HH--S.S--S.EE..EE-....T.T..T.G..G...G-.S...-...G..G....G.G...E....E.E.E.-.-TT.-.EEEE....EEE-.--S-----.......................
#=GC seq_cons                        ......................s.LYsVQVu...s...uDsRLpVFDpTEGTWRLLCSSR.SNscVAuLSCEEMGFlR.s.........lsa.......S.hsV....pAuus.Gspt.FF..CVc....p.t..c.L..s...au.p...+...l..h....-.s...l......s.C.D.C.p.t.chLs....hlCQ.DCGRRph........................
//
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