#=GF ID   Herpes_ICP4_C
#=GF AC   PF03585.20
#=GF DE   Herpesvirus ICP4-like protein C-terminal region
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1422 (release 7.0)
#=GF GA   25.00 25.00;
#=GF TC   130.80 63.70;
#=GF NC   24.30 22.50;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 90746521 -E 1000 --cpu 8 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11739685
#=GF RT   Identification of a motif in the C terminus of herpes simplex
#=GF RT   virus regulatory protein ICP4 that contributes to activation of
#=GF RT   transcription. 
#=GF RA   Bruce JW, Wilcox KW; 
#=GF RL   J Virol 2002;76:195-207.
#=GF DR   INTERPRO; IPR005205;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The immediate-early protein ICP4 (infected-cell polypeptide 4)
#=GF CC   is required for efficient transcription of early and late viral
#=GF CC   genes and is thus essential for productive infection.  ICP4 is a
#=GF CC   large phosphoprotein that binds DNA in a sequence specific
#=GF CC   manner as a homodimer.  ICP4 represses transcription from LAT,
#=GF CC   ICP4 and ORF-P that have high-affinity a ICP4 binding site that
#=GF CC   spans the transcription initiation site. ICP4 proteins have two
#=GF CC   highly conserved regions, this family contains the C-terminal
#=GF CC   region that probably acts as an enhancer for the N-terminal
#=GF CC   region [1].
#=GF SQ   23
#=GS D1FXY1_FHV1/907-1331        AC D1FXY1.1
#=GS ICP4_HHV11/812-1253         AC P08392.1
#=GS A0A172DSS9_9ALPH/902-1321   AC A0A172DSS9.1
#=GS Q77LS1_CHV9D/719-1155       AC Q77LS1.1
#=GS J9R0A4_9ALPH/1-329          AC J9R0A4.1
#=GS A0A1V0M8R0_9ALPH/1192-1605  AC A0A1V0M8R0.1
#=GS ICP4_HHV2H/858-1276         AC P90493.1
#=GS ICP4_VZVD/750-1187          AC P09310.1
#=GS Q5PP75_SUHV/973-1036        AC Q5PP75.1
#=GS Q9DH52_MEHV1/1711-2139      AC Q9DH52.1
#=GS A0A1R3TFR1_9ALPH/1240-1669  AC A0A1R3TFR1.1
#=GS J9QYQ8_9ALPH/489-614        AC J9QYQ8.1
#=GS A0A7L7YUB5_9ALPH/805-1220   AC A0A7L7YUB5.1
#=GS A0A060PYC4_9ALPH/740-1154   AC A0A060PYC4.1
#=GS A0A7S9VMA2_9ALPH/875-1302   AC A0A7S9VMA2.1
#=GS A0A7T1L7L0_9ALPH/720-1136   AC A0A7T1L7L0.1
#=GS Q5PP75_SUHV/1033-1370       AC Q5PP75.1
#=GS Q7T401_CHV1E/732-1146       AC Q7T401.1
#=GS A0A286MM89_9ALPH/895-1339   AC A0A286MM89.1
#=GS ICP4_EHV1B/993-1418         AC P28925.1
#=GS ICP4_GAHVM/1861-2284        AC Q9DGT6.1
#=GS E2IUH2_SHV1/901-1316        AC E2IUH2.1
#=GS E6Y373_9ALPH/1142-1551      AC E6Y373.1
D1FXY1_FHV1/907-1331                   ........GGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAITFDPGALATIAARCTGPRR......QEGT------------.-GLGGLVVSAPLRRASAWMT.QIADPEDVKVVVLYNPLPHEH..........LAH......Q.NpnrD.SRHT...P.....AWSETK.GGLSTLLAALGNR.LLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPATGPAVSHYHL.YIRATVTPTAYCAVRWP...ALEDLSRAVLTSSAIFGPGSFARVEA.AFERLYPNCDGLRLCASGNVGYTVRTDAGDRTPVPMLPREYRQRVLPAYDGCKDM.EA.QS.AGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRR.AL-...ASTDPTRIPAvVRAFCRTALLAPDTEAPPLILT---------..PADPQSAIIENI.PGVTWDSGFGKQETV.............................
ICP4_HHV11/812-1253                    ........GGWRRQPPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAPaaqaacGGGDDDDNPHPHGAAGgRLFGPLRASGPLRRMAAWMR.QIPDPEDVRVVVLYSPLPGED..........LAG......G.G...A.SGGP...P.....EWSAER.GGLSCLLAALANR.LCGPDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHA.YLACELLPAVQCAVRWP...AARDLRRTVLASGRVFGPGVFARVEA.AHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAA.SG.TT.DAMAPGAPDFCEEEAHSHAACARWGLGAPLRPVYVALGRE.AVR...AGPARWRGP-.RRDFCARALLEPDDDAPPLVLR---------..GDDDGPGALPPApPGIRWASATGRSGT-v............................
A0A172DSS9_9ALPH/902-1321              ........GGFRRIPSGDCHTPVPRDIVKSIYCSPETVKELTDHPLFPEAWRTALSFDPQALSTIASRCTGQTS......---D-----------D.RKFGSLVVSGPLKRRVAWMH.QILDPEDVKVVILYNPLPFED..........LAQ......E.NpnqD.KQKV...P.....RWSTTK.GGLSTLLAALGNR.IFSEKSHAWAGNWTGKPVIDSLNSQGVLLLSTKDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPELGPAVSNYHL.YIRAKLSPAAYCSIRWP...EDKDLNRTVLASSSLVGPGSFARAEA.AFARLYPNSDPLKLCSSKNVSYTVKTAAGERTVVPLNPRDYRHKVLPAYDGCKDM.TT.QR.VGLKLDDPDFVDGTAFSHRACNRWGLGASLCPIYLASGRK.ALE...TT-NMEHIPInVRKFCNEAILEPCADSTPMIINPSQ------..------S-----.---------------lpskvpsiiwehgfghigt..........
Q77LS1_CHV9D/719-1155                  ........GCFRRVPAGALHTPVPSEAARRAYCAPNVIESLVDEPMFPPAWRPVLRFDPAAVAEISAR----GH......GG------------VD.RRFGPPSGVDALRRRCAWMH.QVADPEDVRLVIIYDPLPGES..........LCG......P.T...C.MEGG...Asr.dvHWSDCR.GGLSVVLAALSNR.LCLPDTHAWAGNWSGPPDVSQLNARGILLLSTRDLAFAGAVEYLGSRLASAGRRLLILDAVAPERWPRDGPAISQYHV.YVKAPARPDAQAVVRWPr.aTEAGLARAVFASSRTFGPGSFARVET.AFSNLYPNEQPIRLCRGANVCYVVATRAGPRTRVPLSPRDYRQYVLPGFDGCKDI.AR.QA.QGLAVGAADFVDDAAYSHRAANRWGLGAPLRPVYLPEGRR.PGS...AGPRPSDVPLwARVFCRHALPEPDPEAEPIILPPVAGRSVAVfsCMSEARESLPPI.PRILWPPGFGSGET-a............................
J9R0A4_9ALPH/1-329                     ........------------------------------------------------------------------......----------------.------------------MR.QVPDPDDVRVLVLYAPLPGEE..........LGG......-.L...A.P-AP...P.....EWTTER.GGLSFLLAALANR.RCTPDSAAWAGNWTGPPDVSALNARGVLLLSTRDLAFAGAVEFLGLLAGAAGRKLVVVNAVPADAWPEDGPAVSAQHE.FLACAVRPEAQCDVRWP...GADDLRGAVLAAPAVFGPGLFARVEA.AHARANPGAPPLRLGRAGDVRFCVRTRVGEATRVPLAPREYRLAAAPALDSRAAAtSA.AA.EAMAPGAADFRDGAAHSHRACARWGLGAALRPVYLALPRG.AAR...AGPEAVPA-A.LRAFCAAALLEPDPEAAPLVLAA--------..GED-----PPPP.PSIRWASAAGR----lgta.........................
A0A1V0M8R0_9ALPH/1192-1605             ........GGFRRVPPEYSHTPRPSVTLDAAYCDPETTAELIDQPMFPRKWRHALMFDPGALCDIAAA----RK......-GGP------------.-------AADRLARRAAWMK.QIQDPEDVKVVILYCPLPGED..........LTG......P.I...A.NEKS...P.....TWSDRK.GGLSLLLAALSNR.LCTRDSHAWAGNWTGPPNVSALNNRGVLLLSTGDLCFAGAVEYLCLRAGSARRKLAIVDTVEAQDWPSDGPAVGESHF.YVRARLEPRSQCCLRWP...DDRDLRRVVLSSSVIFGPGVFVRVEN.LYQSLYPEESPLCLCRGSNVTYTVHTRVDPRTVVPLSARDYRDAVLPRFDLCKDM.NA.QS.SGLGLDEADFRGAETHGHRAVNRWGLGTPFRPIYVAQARR.RPF...AHPLEIPEE-.TRQFCGEVLLAPDLSAGPSIVDPL-------..------------.---------------appdrlrvrlhrlaeqtvtwgpgdgpett
ICP4_HHV2H/858-1276                    ........GGWRRQPPGPSHTPAPSAAALEAYCAPRAVAELTDHPLFPAPWRPALMFDPRALASLAARCAAPPP......GGAP------------.AAFGPLRASGPLRRAAAWMR.QVPDPEDVRVVILYSPLPGED..........LAA......G.R...A.GGGP...P....pEWSAER.GGLSCLLAALGNR.LCGPATAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLAGACDRRLIVVNAVRAADWPADGPVVSRQHA.YLACEVLPAVQCAVRWP...AARDLRRTVLASGRVFGPGVFARVEA.AHARLYPDAPPLRLCRGANVRYRVRTRFGPDTLVPMSPREYRRAVLPALDGRAAA.SG.AG.DAMAPGAPDFCEDEAHSHRACARWGLGAPLRPVYVALGRD.AVR...GGPAELRGP-.RREFCARALLEPDGDAPPLVLR---------..--DDADAG--PP.PQIRWASAAGRAG--tv...........................
ICP4_VZVD/750-1187                     ........GGFRRIPRGALHTPVPSDQARKAYCTPETIARLVDDPLFPTAWRPALSFDPGALAEIAAR----RP......GGGD------------.RRFGPPSGVEALRRRCAWMR.QIPDPEDVRLLIIYDPLPGEDin......gpLES......T.L...A.TDPG...P.....SWSPSR.GGLSVVLAALSNR.LCLPSTHAWAGNWTGPPDVSALNARGVLLLSTRDLAFAGAVEYLGSRLASARRRLLVLDAVALERWPRDGPALSQYHV.YVRAPARPDAQAVVRWPdsaVTEGLARAVFASSRTFGPASFARIET.AFANLYPGEQPLCLCRGGNVAYTVCTRAGPKTRVPLSPREYRQYVLPGFDGCKDL.AR.QS.RGLGLGAADFVDEAAHSHRAANRWGLGAALRPVFLPEGRR.PGA...AGPEAGDVPTwARVFCRHALLEPDPAAEPLVLPPVAGRSVALyaSADEARNALPPI.PRVMWPPGFGAAETV.............................
Q5PP75_SUHV/973-1036                   ........GGFRRVPAGETHTPRPSEAALAAYCPPEVARALVDQEVFPELWRPALTFDPAALAHIAARR-----......----------------.--------------------.---------------------..........---......-.-...-.----...-.....------.-------------.------------------------------------------------------------------------------.-----------------...--------------------------.-------------------------------------------------------.--.--.----------------------------------------.---...----------.-------------------------------..------------.---------------gap..........................
Q9DH52_MEHV1/1711-2139                 ......sg--GRRCPVGRLVPETTLPTDIRAYCPPAAAAALMDFAKIPGPWRPAMLYAPECLAEIAA-VANEVP......--------PRATSTVGgGNAE--PSLETLKRHTAWMHhQQHSPEDVKIVVLYKALKGEH..........LFC......V.P...T.PDAAygwP.....RFETTK.GGLSFLLAAMSNR.LCLPSSAAWAGRWKAAPDISPLTQAGVLFLSVGDWGWVGALEYLQHLNIERHHKLIVVDTVDENSRPQGGPQFISEAVrYYRCWIDPLNQCCLRWP...DAPGLDTAVMTSKEVLGPVLLTEVAL.-QCTAEFSCPQPKLCCSANVRYVVDTHLGDDMPVPTSAVFYCAATRQA------S.AQ.PN.EHDPFSQPDFLGGEAHSHRAARRWGLGAPLLPIYLTEAGR.RAI...ASPSLIS-KV.VRYMCGNTVLPPDPHGTPVVINVPEGTSETM..AELTVAHVGRRS.--IGWSTS-------ewhsati......................
A0A1R3TFR1_9ALPH/1240-1669             ........GGYRRIPGGDLYTPVPSASVRNVYCDPDIVAELVDDPLFPQNWRPALMFDPNALATIAARRGAARDd....eAGERYTNNNNNNKNSC.PRFGRLSVTTPLRRQTEWMR.QINDPEDVRVIILYNPLPNED..........LAG......D.P...SkSGQE...P.....QWSDTK.GGLSFLLAALSDR.LCTPKSHAWAGNWTGRPDISVLNKKGVLLLSTGDLGFTGAVEYMCLRTGSARRKLIVLDAVDPADWPSDGPAIGHYHV.YVQASVSPRSHCAVRWP...ECRDLSRTVMASRNVFGPGSFARVEA.AYALLYPTDSPLGLAKGENVSYVVETRAGPQTRVPMAPRDYRSAVLPRLDGCKDM.LA.QS.SELALRDPDFVDGAAYSHRAANRWGLGAALRPVYLAEGRR.VGW...NSPDDIPD-N.IRRFCREAVREPAPG----------------..------------.---------------eastgfvdttgqiptdtprvyweaghg..
J9QYQ8_9ALPH/489-614                   garrarar------------------------------------------------------------------......----------------.--------------------.---------------------..........---......-.-...-.--AP...X.....SXTTER.GGLSFLLAALANR.RCTPDSAAWAGNWTGPPDVSALNARGVLLLSTRDLAFAGAVEFLGLLAGAAGRKLVVVNAVPADAXARGRP-------.-----------------...--------------------------.-------------------------------------------------------.--.--.----------------------------------------.---...----------.-------------------------------..------------.---------------grlraarvpglrgaprgpvrralar....
A0A7L7YUB5_9ALPH/805-1220              ........GGWRRQPPGPSFTPALSAAALDAYCPPNMVEALTAHELFPEPWRNALKFDPRALAALASR---HEP......-----------PSEPG.HLLGPLIVSSPLHRMTAWMK.QIPEPEDVKVLILYSPHPHES..........LGK......T.-...N.PLHR...P.....KWDPERpGGLSFLLAALSNR.LCGPESAAWAGNWSGPPDISVLNAQGVLLLSTDDLGFTGAVEFLGLEASTADRQLIIINTVQPNEWPEDGPTISQRHT.YIQCGVLATAQCFLRWP...QEKPLSQAVLTSSRVFGPKVFAAAEK.AFAHLYPREPLLKLCQGRNVRYRVDTHAGKDQLVPLPPKEYRRAVLPALDSRAAA.SS.IA.EAMGPKAPDFVEGESYSHRACLRWGLRAPLRPIYLSLPRG.AAR...AGPEMVPE-E.MKDFCTKAILEPDLVERPLLVE---------..----HDRALPKV.PGIWWSSPTGR----latv.........................
A0A060PYC4_9ALPH/740-1154              ........GGWRRQPPGPSHTPAPGQAALDAYCPPAVVAELTEHALFPSAWRAALMFDPSALASLAARSAASEP......GSG-------------.RLFGPLRVSGPLRRAAAWMR.QIPDPEDVRVVVLYAPLPGEE..........LG-......G.P...A.P-SP...P.....AWTTER.GGLSFLLAALGNR.LCGPDTAAWAGRWTGPPDVRALGAQGVLLLSVRDLAFTGAVEFLGLLASASERRLIVINAVPEAEWPADGPTISQQHV.YLPCSVTPRAQCDLRWP...DAPDLARAALTSGRVFGPGVFARAEA.AFARLYPGEAPLRLARARNVRYCVDSRLGEQTAVPLSPREYRRAILPALDSRAAS.SR.LG.DAMGPGAPDFCEGEAHSHRACLRWGLGAPLRPVYLALPRG.AAA...EGPAAVPA-A.LRDFCARALLEPEEDAAPYRLK---------..----AGDALPPA.PGVRWASAVGRLDT-v............................
A0A7S9VMA2_9ALPH/875-1302              ........GGFRRVPRGECHTPAPGEAARAAYCAPEAVDELVAHPLFPEAWRPALTFDPSALATIAARRQGP-P......------------AREG.ARFGELVPSGPLRRRAAWMR.QIPDPEDVRVVVLYHPLPEED..........LLGglpgggG.G...A.RREG...P.....RWSDRK.GGLSALLAALGNR.LLTRGSHCWAGNWTGAPDVSALNRQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVLDAVDPEDWPAAGPAAGRDPP.YMRARLAPRAACAVRWP...AERDLARAVLTSGSVFGPVFFARVEA.AFARLYPGQAPPRLCRGDNVAYVVATRAGERTRVPMAPRDYRQRVLPVYDGCKDM.RA.QS.EGLAVFDPDFDEGAARSHRAANRWGLGAALRPLYLAAGRR.GALdedARPADLLPPA.LREFCRVALLEPDGEAGPVVLRVGE------..------------.---------------alperaphvewepgfgarsta........
A0A7T1L7L0_9ALPH/720-1136              ........GGWRRQPPGPSHTPAPGAAALEAYCPPRIAAELTAHALFPEPWRAALLFDPAALASLAARRAAPEP......GSG-------------.RAFGPLRVSGPLRRAAAWMR.QVPDPEEVRVLVLYAPLPGEE..........L--......G.G...A.SPAP...P.....AWTAER.GGLSFLLAALANR.RCTPASAAWAGNWTGPPDVSALNARGVLLLSTRDLAFAGAVEFLGLLASAADRRLVVINTVPEDVWPRDGPALALHHE.FLPCAVRPAAQCDLRWP...GAADLRRAVLASPGVFGPGLFARAEA.AHARLNPGAPPLRLGRAGDVRFCVRTRVGEATRVPLTPREYRLAALPALDARTAA.SSaAA.AAMAPGAADFRDEEAHSHRACARWGLGAALRPVYLALPRG.AAR...AAPEAVPA-A.LRAFCAAALLEPDPEAAPLVLDV--------..----GGGAPPAP.PGIRWASAAGR----latt.........................
Q5PP75_SUHV/1033-1370                  .....rga------------------------------------------------------------------......----------------.----------PLRRRAAWMR.QIADPEDVRVVVLYDPLPHEE..........LCA......E.P...A.EGAP..rP.....AWDPRR.GGLSALLAAFAHR.LCTPDSHAWAGNWTGRPDIGRLNAQGVLLLSARDLGFAGAVEYLCSRLGAARRRLIVLDTIE--DWPADGPAVGDYHV.YVRVRLDPAAQCAVRWP...GCRELRAAVLDSSSIVGPACFARVEA.SFARLHPGAEPLRLCRQDNVRYTVSTRAGPRTPVPLPPRAYRQRVLPTVDGCKDM.AR.QR.SALGLGDPDFDAGAAFGHRAANRWGLGAPLRPVFVSCGRR.GLAe.lRGPEGLPAE-.LRAFCAAALLEPDAEAAPLVLTPGA------..------------.---------------vaaagappavlwdfap.............
Q7T401_CHV1E/732-1146                  ........GGWRRVPPGPSHTPAPSAAALEAYCAPRVVAELTDHPLFPEAWRAALAFDPRALASLAARCGPPEP......GSG-------------.RAFGPPRASGPLRRAAAWMR.QVADPEDVRVLVLYAPLPGEE..........L--......G.G...A.SPAP...P.....AWTDAR.GGLSFLLAALGNR.LCGPDTAAWAGNWTGPPDVSALGAQGVLLLSTRDLAFAGAVEYLGLLAAAAGRRLVVVDAVPPEEWPADGPAVARRHV.YLPCAVLPAAQCDVRWP...AARDLRRAVLASGRVFGPGVFARVEA.ACARLYPDAPPPRLGRGANVRYRARTRLGPDTPVPLPPREYRRAVLPALDGRAAD.SP.AR.EAAAAGAPDFRRGEAHSHRACARWGLAAPLRPVYLALDRD.AAR...AGPDALP-PA.LRAFCARALLEPDPDAAPLVLR---------..ADADADP--AAA.PRVRWAAGRG-----dtl..........................
A0A286MM89_9ALPH/895-1339              ........GGFRRVTPGRYYTPAPSRAALDAYCGPEIVDGLVHHEILPEKWRAAFAFDPEALAALAARCTSPRV......GGGG----PGP-----.GGLGRLVVTDPLRARLAWTR.QIEDPEDVRVVFMYAPLPGESlagpparaasAAA......A.A...A.DDDE...Pad.gpRWPPAR.GGLSHLLAALGNRaLVGPGDQAWAGRWTAPPDVSALNARGVLLLSTRDVGFVGAVEYLCARFAAARRPLIVADAVAPEDWPRDGPAVPEGHV.YLRAALRPEAHCALRWP...EAPELGPVVLTACRVVGPGFFERVER.EHARLYPGAPPLALCRGANVTFVVATRAGPRTPVPLAPREYRGRVLPALDGCKDM.AA.QS.GALGLGAPDFANGETVSDRAANRWGLGATLRPVYLPVGRD.FDR..lRGPGDLD-PA.VAAFAAAARLLPDPDAPPFALP--AGLAGDAdpEARAAARARVP-.---------------apppqavwdrp..................
ICP4_EHV1B/993-1418                    ........GGFRRVPRGDCHTPRPSDAACAAYCPPELVAELIDNQLFPEAWRPALTFDPQALATIAARCSGPPA......RD-------------G.ARFGELAASGPLRRRAAWMH.QIPDPEDVKVVVLYSPLQDED..........LLG......GlP...A.SRPG...GsrrepLWSDLK.GGLSALLAALGNR.ILTKRSHAWAGNWTGAPDVSALNAQGVLLLSTGDLAFTGCVEYLCLRLGSARRKLLVLDAVSTEDWPQDGPAISQYHI.YMRAALTPRVACAVRWP...RERHLSRAVLTSSTLFGPGLFARAEA.AFARLYPDSAPLRLCRSSNVAYTVDTRAGERTRVPLAPREYRQRVLPDYDGCKDM.RA.QA.EGLGFHDPDFEEGAAQSHRAANRWGLGAWLRPVYLACGRRgAGA...VEPSELLIPElLSEFCRVALLEPDAEAEPLVLPITEA-----..------------.---------------prrraprvdwepgfgsrst..........
ICP4_GAHVM/1861-2284                   ........AAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADI-ARVANALP......--GKYNSNEIITSAAS.EAFH--TATSKLRARTAWMRyQQESPDDVSIVVLYSPLPGEH..........LFC......V.P...A.PDTP...Pg..glKFDNKR.GGLSFLLAAFSNR.LCLPKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATrYMKCIISPRSQCCVRWP...GLLDFGTTIITSRDVVGPLTLMDLEQyYYCEIGIEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLFYFAAVKHV-------.--.--.------RPDFLCGETYSNRAARKWGLCAPLRPIYVIESKM.NAI...VSPSFLH-PT.ARNLCRSVILPPDPEARPVVVHIPEGTCSAL..AEDMVASIRSSC.--ITWGQ---HEEG-gpe..........................
E2IUH2_SHV1/901-1316                   ........GGWRRQPPGPSHTPAPGAAALEAYCPPERVAELADRPLFPAPWRAALMFDPGALAALAARCAPPEP......GSG-------------.RAFGPLRVSAPLRRAAAWMR.QVPDPEDVRVLVLYHPLPGEE..........LGG......P.P...G.PE-P...P.....AWTADR.GGLSFLLAALANR.RCTPDSAAWAGNWTAAPDVSALNAQGVLLLSTRDLAFAGAVEFLGLLAGASGRRLVVLDAVEPADWPADGPAVALRHV.YVPCSVRPGAQCDLRWP...GCEELRRAVLVSPRVAGPGSFARAEA.AYARLYPDAPPLRLARAGNVRFAVRTRLGPRTSVPVPPRAYRRAVLPALDGRAAA.SR.LAgAAMGRGAPDFCGDETFSHRACDRWGLGAALRPLYLALGRG.PAP...RRPDDVP--AaLRAFCAAALLEPDDDAAPLLVGPDADP----..------------.---------------aaapgvrwasasgrvgt............
E6Y373_9ALPH/1142-1551                 ........GGYRRVPTGITHTPLPTESARSTYCQPDIVAELLDDPMFPPNWKPALMFDPEALARVAAR------......RGGS--------HVEG.RLYGPLRVTDPLRKQCAWMN.QIPDPEDVKVVIMYCPLVGEE..........LSA......A.P...V.ASCM...P.....MWSDEK.GGLSFLLAALCDR.LCSYGSHAWAGNWTGVPDISALNSRGVLLLSVRDLGFAGAVEYLCLRLGSAHKRLIFLDTIDTVDWPADGPAISSYHS.YIKATITPQAHGAHRWP...DCEAMSRVVMTSRGIVGPGVFARVEA.AFAQLYPNEPPLQLMRGDNVKYVVETKAGRTTRVPMTPREYRGLVLPQYD-RKDM.AF.QA.DGLSISGPDFLEGAAYNHRAANRWGLGAPLRPLYLTESRK.HPF...ETPDDIP-EV.VRSYCAAALLEPQMEGNVCVVNP--------..------------.---------------ntiqrgqrpptitwelc............
#=GC seq_cons                          ........GGaRRhPsGssHTPsPutuAhpAYCsPchlsELsDcslFPpsWRsALhFDPtALAslAARhts..s.......t...............ttaG..hsosPLRRtsAWM+.QlsDPEDV+VVlLYsPLPGE-..........Lss......s.s...u.stss...P.....pWospR.GGLShLLAALuNR.LCsPcStAWAGNWTGsPDVSALNApGVLLLST+DLAFAGAVEYLsLhhuuAcR+LlVlDsVssp-WPtDGPAlup.Hs.YlpstlpPtAQCslRWP...ssc-LpRsVLsSsplFGPGsFARlEA.AaA+LYPsssPL+LCRuuNVpYsVcTRsG.cThVPhsPR-YRptVLPuhDuptsh.ut.tu.puhuhusPDFh-GtAaSHRAssRWGLGAsLRPlYLu.uRc.ssh...suPstls..h.lRsFCstALLEPDs-AsPlllp.......................................ss...........................
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