#=GF ID   Herpes_U5
#=GF AC   PF05999.17
#=GF DE   Herpesvirus U5-like family
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   Pfam-B_8027 (release 9.0)
#=GF GA   25.00 25.00;
#=GF TC   26.70 32.70;
#=GF NC   22.80 21.50;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21320693
#=GF RT   Antiviral inhibition targeting the HCMV kinase pUL97 requires
#=GF RT   pUL27-dependent  degradation of Tip60 acetyltransferase and
#=GF RT   cell-cycle arrest.
#=GF RA   Reitsma JM, Savaryn JP, Faust K, Sato H, Halligan BD, Terhune
#=GF RA   SS;
#=GF RL   Cell Host Microbe. 2011;9:103-114.
#=GF DR   INTERPRO; IPR010302;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of Herpesvirus includes U5, U7 and UL27. UL27
#=GF CC   promotes a cell cycle arrest in G0/G1 by inducing the
#=GF CC   proteasomal degradation of host histone acetyltransferase
#=GF CC   KAT5/Tip60 [1].
#=GF SQ   23
#=GS I3VPZ5_9BETA/167-558       AC I3VPZ5.1
#=GS A0A0K1H091_9BETA/142-572   AC A0A0K1H091.1
#=GS VU5_HHV7J/425-846          AC P52522.1
#=GS G8XSU1_9BETA/136-266       AC G8XSU1.1
#=GS A0A192XNI0_9BETA/787-1209  AC A0A192XNI0.1
#=GS A0A7T7DGC3_9BETA/144-574   AC A0A7T7DGC3.1
#=GS Q8QS61_9BETA/165-635       AC Q8QS61.1
#=GS UL27_HCMVA/163-603         AC P16763.1
#=GS Q9DWG2_RCMVM/88-381        AC Q9DWG2.1
#=GS UL27_HCMVM/163-603         AC Q6SWA4.1
#=GS G8XTA0_SCMVC/140-565       AC G8XTA0.1
#=GS G8XUA2_9BETA/138-569       AC G8XUA2.1
#=GS U7_HHV6U/785-1208          AC Q01353.2
#=GS Q7TFT5_RHCM6/144-574       AC Q7TFT5.1
#=GS E9RH41_GPCMV/151-529       AC E9RH41.1
#=GS Q91TS2_TUHV1/141-536       AC Q91TS2.1
#=GS VU7_HHV6Z/462-885          AC Q9QJ54.1
#=GS G8XSU1_9BETA/263-492       AC G8XSU1.1
#=GS A2Q6L2_MUHVK/156-448       AC A2Q6L2.1
#=GS A0A0G2UPG0_9BETA/140-565   AC A0A0G2UPG0.1
#=GS K7Y9Z1_RCMVE/155-551       AC K7Y9Z1.1
#=GS I3VQ05_9BETA/59-329        AC I3VQ05.1
#=GS A0A1P8VIS1_9BETA/50-410    AC A0A1P8VIS1.1
I3VPZ5_9BETA/167-558                  .vcgas-----FRPDTCPIVQRLAVAVASGQYAVNTLLNYRNK.SSVAYYIKYLSKKIMFCYRELK..E.RSAGL.TD..KLS...R..LAAGGMMPLPVCR.-KSGLG--QNYRSkAYLLDPEFVAESFRSLQFVYRYLCGCGGC..C.Y-----.-TNSLAWMYP-------NVPL.EANHVLF...NRCAEM--------GPIWLPPIRHLTAEQRIEMCRMFSEDLCL.SV.W.RSGE..VE---DTDVFPCTAPES..LDPV...KWS....VIHLSESICSILSVLKALSSVLSTELNAYATYLQEDVNVIGDMLWDKGYGLSQ.AVA.............RDPS.............QAGRFNR.Y.DGLPDMFRGLR....FGSDAVSFFDAVCCLLECANVVPEY...DALPEYSAREELLLHNFFIRRIYT-----------.....---.......-----..EM---...-----------------------------------------------------------------------------------------------------pdetrlaepylvhclrhgdflpqdavslrslrlelsnaelcnsrmhkgfwepl
A0A0K1H091_9BETA/142-572              ..vaag----PFLPEISKSGKRIALAVATGQYAVSTLLNYKVF.GNKTHYLRQLCVITEELFRRLA..G.TVCLF.LD..AGD...R..DLIQKCLPSHLCK.-KLPVN-YRVQKN.AVFFNSRFGLRAEAALHTLYARFCTCGDC..H.DLFAAS.SDTQATP-------SEDEPS-.--PPQPR...LEDAELTLLHNAHLGKFHLPAIRHLTAAEQLRVQQSVARDLGF.TD.W.SHTL..VD---DYFLLPVGLSCG..-TPC...EGY....AMYLMSNAVLALKVIRLLYITIRHEHSACVRALCKDVAFLIRMFRYEASIIRK.GLA.............QNAA.............QRMELSR.F.R--RHIHDLKH....IHFTVSNFLETFCDFIKIVNKIPDY...QCISLTIKRELVLLHLLRLRR--------------.....---.......-VYEC..PSAET...RKGEKLAWYYFRHGDVTLDPGILMT-----------------FDSLLADCELSNNANRCRRKAPFEIPT----SATVTVRYQGHIEKLHRLYVRRFRPHEV.....................................................
VU5_HHV7J/425-846                     .....l-RDLKFMEDFDPKWQCITKLAAVGFYSGASLFNLGAK.PGIGYWCRYLCEYLSMLFFKLD..G.KLKEL.SK..ESK...Q..KLGG----FSCAF.WSESFKTEMQNKT.ESFFRRDFFDRFQLYLLEHFLLFCGCEEC..R.YNFFRFkNVGTMKKNPG-----------.----SVK...LHFFPA-------LGKIDLPIFPHLSEKYS-NLSMFVAKDLCL.--.-.--SF..IEGQIEHSRFPISVTVD..MGQD...KRN....LLNILSNIVFLLFIIQTLNSVLFTELKMYYDVYLDELKNLESSMECEMKLGSK.GCM.............----.............--NNIVY.F.NMLKQVKDIVR....NPGTSSNFIFNCLEVIKMSFEIPYY...KNYDETNFMESFYLHHLYIQR-QPAKHTDLVAANN.....LAP.......GFFIV..NAKEK...SFIDVL------------ERSIVNIEAEYLSNTKNINGAMALFFSGLKYFGNFGNG-------------NFQTSPEKDVRAVGY--KLGGLDKI-------qndlcy...............................................
G8XSU1_9BETA/136-266                  .....l-QQAQFLPHTSRFARTACISMATAQYLMCTLINYKEC.GSLTHYMRQLCSMTGEIYDRLA..G.TLPLF.DD..PET...K..NVIRKFFIDDLCQ.-EAGL-DYRVLRN.AVFFKTEFQQACERALAALYAHLCICGDC..N.E-----.---------------------.-------...-------------------------------------------.--.-.----..-----------------..----...---....-----------------------------------------------------.---.............----.............-------.-.-----------....-------------------------...-----------------------------------.....---.......-----..-----...-----------------------------------------------------------------------------------------------------tvepn................................................
A0A192XNI0_9BETA/787-1209             .....i-QDLKFMDDFDPKWACITKLAAIGFYSGASLFNLGAK.PGIGHWCRYLCEYLSMLFFKLD..N.RLREL.TK..ESK...E..KLGG----FSCAF.WSESFKIEMQNKT.ESFFRRDFLDRFQLYLLEHFLLFCGCEEC..RfNLFRFK.NLGTMKKNLG-----------.----CVK...LHFFQA-------LGKIDLPIFPHLAEQYSRNLVTFLARDLCL.--.-.--SF..IEGQIERCKLPISINLN..VTQD...KKN....LLNILSNIVFLLYVIQTLYSVLLTELKMYYDVYIDELKNLATSMEFEIKLGSK.GCL.............----.............--NNVRY.I.SMLNQVLDMIG....NPGTSTNFIFNCLEAIKIGFEIPYY...QNYDESKFLDSFYLHHLYIKR-HGEKSVDLIAADN.....LAP.......GFFIV..NAKER...RFIDVL------------EKSILNIEAEYLSNTKNINGAMAIFFSGLKYFGNTGYG-------------EIQVSPEKDVRAIGY--KLGSLGK--------iqndiyy..............................................
A0A7T7DGC3_9BETA/144-574              ..vaag----PFLPEISKSARRIAVAVATGQYAVCTLLNYKIF.GTKTHYVRQLCVLTDELFRRLS..G.TMCLF.LN..PDE...R..ELIDKCSPVSICK.-KLSLN-YRAQKN.AVFFHPRFHVRAEEALKALYAKFCTCGDC..H.E-S---.-----PLPN-GSDAATATSTA.TESPRPR...LEDAELRLLNYTQLGKFHLPAIRHLTAAEQLRVQQSVARDLGF.AD.W.SNTL..VD---DFFLLPVGMSCG..-TPC...QGY....AMYLMSNTVLALRVIRLVYITIRHEQNACVRALCRDVECLIKMFRYESFSIRK.GLV.............HNAA.............QRMELSR.F.R--RHVQDLKQ....IKFTVNDLVETFCEFLKIVNKIPDY...QCVSLNIKRELVLLHLLKLRRV-------------.....--Y.......DFSSA..DTR--...-KSERLAWYYLRHGDVPLDAGLLMT-----------------FNSLLADCELSNNANRCRRKVPFEIP----ASAAVTVRYQGHLEKLNRLHVRRFRPHEV.....................................................
Q8QS61_9BETA/165-635                  ......VHRARYLPEISRAAKRMALAVATGQYVVCSLLDYKSF.GTRTNYLRQLCTLTEELYMRLD..G.TMCLF.LD..PEE...R..EVIARCLPQFLCR.-GLAVR-YRSHRA.AVFFNATFGARAETALKRLYSAFCECGDW..R.DPDVPV.EAAEAVAAA--SQHAHMLP--.--PPHFH...LENAELRLENNRHLGAFHLPAIRHLTVDDISRIRASVSRDLGF.AE.W.SQTL..VD---DYFLLPTGWACA..-NPR...RGY....VMYLASNAVLALRIIRLLHASIRHEQTACVRMLSGDVQRLIRLFKGEAAMLRK.GLA.............QNPV.............QRRELSR.F.R--KHVHDLKR....VRFTVDGFVESFCDFLDVIHRIPDY...RCISLRIKRELLCLHTFKLRRVYRPPPSSLLAGSHhnnsvVLPpptttnaSSPAPssPHPDPqllLRAERLAWHYLRHGDVPQDRSRLPQ-----------------FSSALSDAELSNNANRCRRKAPVEFAG---FAGGPSVRYRAHIQRFDRLYVRRFRPHEV.....................................................
UL27_HCMVA/163-603                    ......VHEAQYLPEISRAAKRIALAVATGQYVVCTLLDYKTF.GTRTHYLRQLCSMTEELYLRLD..G.TLCLF.LE..PEE...R..ELIGRCLPAALCR.-GLPVK-YRTHRA.AVFFHATFMARAEAALKDLYAAFCECGDG..R.D-----.NGGNHDGNHDGNDHSSLSPSA.VASHHSR...LEHAELRLERNRHLGAFHLPAIRHLTAGDVARVQDSVSRDLGF.AD.W.SQTL..ID---DYFLLPAGWACA..-NPR...RGY....AMYLASNAVLALRIIRLLRASIRHEYTACIRMLSGDVQRLIRLFKGEAALLRK.GLA.............QNPV.............QRRELSR.F.R--KHVHDLKR....IRFTEDTFVETFCDFLELVQRIPDY...RSVSLRIKRELLCLHVFKLRR--------------.....---.......GCRAP..PTPET...ARVQRLLWHSLRHGDAPQDRTRLPQ-----------------FSSALSDAELSNHANRCRRKAPLELGPAVVAAPGPSVRYRAHIQKFERLHVRRFRPHEV.....................................................
Q9DWG2_RCMVM/88-381                   ....ia--AMQFRPEANEVVRALCRACVAAQYGVSILFSYDHC.AAVPRYLRSLVQELVELNDRIRhlS.IVSNLrVE..AED...L..GVIQGVLPERVAA.-LLGVP----AAH.ELFLSDEYYDCVEAAVDAMFDRFCECAECgmR.RSERIV.AVRAR--ALG--DARGLTARRgMLRKKRRnrfFEENDVALPFCPELGRLRLPRIRHLDLVQQELLCRHIGRDLMF.-D.S.MFGV..CRGMSRMRGVPIPFCSAekLNLD...LAY....VLYLASNSYFLCFLIRTVRDVMRHEERAYGELCLG------------------.---.............----.............-------.-.-----------....-------------------------...-----------------------------------.....---.......-----..-----...-----------------------------------------------------------------------------------------------------lardaaralredvearvaagavp..............................
UL27_HCMVM/163-603                    ......VHEAQYLPEISRAAKRIALAVATGQYVVCTLLDYKTF.GTRTHYLRQLCSMTEELYLRLD..G.TLCLF.LE..PEE...R..ELIGRCLPAALCR.-GLPVK-YRTHRA.AVFFHATFMARAEAALKDLYAAFCECGDG..R.D-----.DGGNHNGNYGGGDHSSLSPSA.VASHHSR...LEHAELRLERNRHLGAFHLPAIRHLTAGDVARVQDSVSRDLGF.AD.W.SQTL..VD---DYFLLPAGWACA..-NPR...RGY....AMYLASNAVLALRIIRLLRASIRHEYTACIRMLSGDVQRLIRLFKGEAALLRK.GLA.............QNPV.............QRRELSR.F.R--KHVHDLKR....IRFTEDTFVETFCDFLELVQRIPDY...RSVSLRIKRELLCLHVFKLRR--------------.....---.......GCRAP..PTPEA...VRVQRLLWHSLRHGDAPQDRTRLPQ-----------------FSSALSDAELSNHANRCRRKAPLELGPAVVAAPGPSVRYRAHIQKFERLHVRRFRPHEV.....................................................
G8XTA0_SCMVC/140-565                  ..vaag----PFLPEISKNAKRIALAVATGQYAVCTLLNYKVF.GSKTHYLRQLCVITDELFRRLA..G.TMCLF.LN..PDD...R..DLIEKCLPLSICQ.-KLSLD-YRAQKN.AVFFHPRFSARAEEALKGLYARFCNCGDC..H.D-----.------TPLP----DVLLDSS.QEEPRPR...LEDVELRLLNNAQLGKFRLPAIRHLTASEQLRVQQNVARDFGF.TY.W.SNTL..VD---DYFLLPVGSSCG..-TPC...EGY....VMYIMSNAVLALRVIRLLYISIRHEQDACARALSKDVQCLIKMFRYEASVIRK.GLA.............QNAA.............QRMELSR.F.R--RHVHDLKQ....ISFNVDNFVETFCDFIKIVNKIPDY...QCISLNIKRELVLLHLLRLRR--------------.....---.......-VYES..PSPET...TKGEKLAWYYFRHGDVALDPGLLMT-----------------FNSILADCELSNNANRCRRKVPFEIPATA----RVTIRYQGHLDKLHRLHVRRFRPHEV.....................................................
G8XUA2_9BETA/138-569                  ....ls--QARFLPNVSRVAKRLCLAMATAQHVVWSLLNYKCC.GTITHFLRQMCSLTVDIYDKLY..D.TLALF.QD..DDT...K..IAIQQFFINRLCE.-GAGLD-YHGHRH.AVFFKLEFRRAAERALALMYRQLCGCEEC..G.G-----.--TTAASNAG--PDSEQRPNV.HA--WPR...LESVAISLSNYPDLGRFHLPALRHLKAAEQTRLRDAVSRDLGF.SL.W.NHNG..FE---PRFLLPQELRGT..--TD...KSY....VLFLVSNIVFNLKIIWILRQIVQREFADAVQFLAFDRDILIGYLHRRHALFQE.GLV.............QSEA.............HRQLVAD.CqRYLADLRDIDF....ANFERRTFVESLCAFMDLAEQIPDY...RQLSLIDKQRQFLLHNFRIRC--------------.....---.......-LYET..PSPET...RLGESLCWYYLKRGDVPLGKEALLK-----IN------------TRLSDAELCNDANRCRRRTWLDL-PIVTVLPVKRHMQMA---RYTNVYVRRFQH---gev..................................................
U7_HHV6U/785-1208                     ......VKDLKFMDNFNEKWQCITKLAFLGLYAGASLFNFTSK.PTLGYWCRYLSEYASMLLFQFE..S.KLKEL.TK..EST...R..QLGG----YNLCH.WGQELKDCLENKS.DVFFRYDFFERIESCLIEHFMLLCGCVEC..R.RMFIMY.NKRGRKFDFG-----------.---HSVR...IQCFPM-------IGSIRLPAFLHLGEPYDVSLSSLIAKDLGL.--.-.--SM..IEGQIELSRLPISLQIS..VTPD...KKA....LLTFLTNIVFIVFVVNTLYRVINAELDIYYDLFTEEVGKLCVAMEEEMKLGRN.GCL.............----.............--GDLCY.F.SPMKQMKEIVR....CPGEKSQFILKCWEALRIGFSVPAY...KDYDETPFMEMFFMHHLHIKRFHEDNDRDLVSCDN.....LIP.......GFFIV..NTDGE...NFLQRL------------QRVVLPVVEDYLTNTRCINGTMAFFFSGLKYFGSGNHR-------------GFQISPEKDVRAIAY--KLGSLDVLR-DDYKY.....................................................
Q7TFT5_RHCM6/144-574                  ..vaag----PFLPEISKSGKRIALAVATGQYAVSTLLNYKVF.GNKTHYLRQLCVITEELFRRLA..G.TVCLF.LD..AGD...R..DLIQKCLPPHLCK.-KLPVN-YRVQKN.AVFFNPRFALRAEAALHTLYARFCTCGDC..H.DLFVAS.SDTQATP-------SEEEPS-.--PPQPR...LEDAELTLLHNAHLGKFHLPAIRHLTAAEQLRVQQSVARDLGF.TD.W.SHTL..VD---DYFLLPVGLSCG..-TPC...EGY....AMYLMSNAVLALKVIRLLYITIRHEHSACVRALCKDVAFLIRMFRYEASIIRK.GLA.............QNAT.............QRMELSR.F.R--RHIHDLKH....IHFTVSNFLETFCDFIKIVNKIPDY...QCISLTIKRELVLLHLLRLRR--------------.....---.......-VYEC..PSAET...RKGEKLAWYYFRHGDVTLDPGLLMT-----------------FDSLLADCELSNNANRCRRKAPFEIPT----SATVTVRYQGHIEKLHRLYVRRFRPHEV.....................................................
E9RH41_GPCMV/151-529                  ...ldr---VEFRPEATDVVKVMCKALATAAFCMEHHFKYRNP.GSLSGYVRFLNYVACLTYREVE..D.AWSSL.SN..GDAyacR..SLMN-CLNS----.--RKKKGRSGPLQ.KAVMDKEYVSRVNVMFERAQIALCGCDEC..T.S-----.-GSRHMTTRAVG-----RQNV.VEPHLFV...LNYPEM--------GPVNVPTIKHMSVDEQIAYCEGVRGDCLC.-S.Y.AKKIkvWKDVLDPDTLPVKPDYS.hLLSE...RAR....FLTMVANFIVLCQMTQLAAAVLKCEICRCVVAVKELTQEVSEIVTRQSDLFAGgGLV.............ESKAa..........rsQHKALRR.L.S--SRLRGLNF....GGGSGLIFLPAMGELLKLSTMVSEY...SEINEIQTREELLLHVMFLRRMYDDTSEDMYRAER.....LVQ.......-----..-----...-----------------------------------------------------------------------------------------------------falrhgcgspytpqdvsrtvt................................
Q91TS2_TUHV1/141-536                  ...lnt---VAFRPEASDVARHVARTVAVGQYAVQTVFDYRNP.GGLSHYLRFLCESVHALYGRLE..-.RIGDT.LD..DRA...R..LLIADLLPRAVCR.-QLGYA-YDPDDQ.TFIFDPQYLHASEQVLQILYDRLCDCEEC..Q.ERRFTA.AAAATSLRRG--PKR-----R.KRSSWAA...FERRDVVLEQYRELGVLRLPCLRHLKRDQQLELCQQLRHDLCF.-R.R.RQTL..TA---RELLLPIGVPCG..HGVS...DAY....ALYLASNLVFTLFLAQTLHAIVRIEARAYIDLLSGHADALVGALRRQASYLQH.GGLgdgdgndagpsggRSPS.............DGRKLAR.L.T--RRLRGLDFgfggGSGSGTAFFTAFCDFLEIVEKLPDY...ARLSEFQVREELLVHHFYLAQVY------------.....---.......-----..-----...-----------------------------------------------------------------------------------------------------adpspetqagerlvsyyvqngdaccqdaarlra....................
VU7_HHV6Z/462-885                     ......VKNLKFMDNFDEKWQCITKLAFIGLYAGASLFNFASK.PTLGYWCRYLCEYASMLLFQFE..S.KLKEL.TK..EST...R..QLGG----YNLCH.WGQELKDCLENKS.DVFFRYDFFERIESCLIEHFMLLCGCVEC..R.RMFIMY.NKRGRKCDFG-----------.---HCVR...IQCFPM-------IGSIRLPAFLHLGEPYSVSLSSLIAKDLGL.--.-.--SM..IEGQIEHSRLPISLQIS..VTPD...KKA....LLTFLTNIVFIVFVVNTLYRVINAELDIYYDLFTEEVGKLCVTMEEEMKLGRN.GCL.............----.............--GDLCY.F.SSMKQMKEIVR....CPGEKSQFILKCWEALRIGFSVPAY...KDYDETRFMEMFFLHHLHIKRFHEHNDRDLVSSDN.....LIP.......GFFIV..NTHEE...NFLQRL------------QRVVLPVAEDYLTNTRCINGTMAFFFSGLKYFGSGNHR-------------GVQISPEKDVRAIGY--KLGSLDVLR-DDYKY.....................................................
G8XSU1_9BETA/263-492                  vepnvp-------------------------------------.----------------------..-.-----.--..---...-..-------------.-------------.-----------------------------..-.------.---------------------.-----CR...LESVPLVLANYRDLGSFRLPALRHLTQSEQRRVRHAVSCDLAF.AL.W.NQTT..SE---PRYLLPSGLSCG..-EVR...RNY....VMYLASNIVFNLKLIRMLHRVIQREFMDGVRFLSSDRDLLVGMLRQRYVMHEK.ALV.............KNPR.............HQKVASEcL.QQIVELRDLDF....SNTGKRSFVESVCDLQDVLKRVPDY...Q-ISLREKQQMFLLHHLRLRRFYTESSSETKLGEN.....LI-.......-----..-----...-----------------------------------------------------------------------------------------------------wyylkrgnevs..........................................
A2Q6L2_MUHVK/156-448                  ...lfd---LEWRPEASDSCKALGRATVAIQYAISLLYGYDRS.ASMSRYLRRLVNELIDLHDRMR..NmSLMSS.LR..IPG...RdlEIVQRLLPERICQqLGIPFS----F--.ESCLLDSYYEYVEMTMEVIYDQLCYCREC..R.MRRGER.LERLRAQKIG-TKYRRRNPDG.IRL----...FEENYVRVAAYPNIGVLRLPKIRHLSDEHQTLVCGHLARDLMY.DVhFgSSSP..L-ARVNGIPLPFTAVDC..MDID...LGY....ALYMANNVYFMLFLIRCVRDVVRSEQREYVDLVTGLVREASVMLRRDVD----.---.............----.............-------.-.-----------....-------------------------...-----------------------------------.....---.......-----..-----...-----------------------------------------------------------------------------------------------------ariragadrpvfvas......................................
A0A0G2UPG0_9BETA/140-565              .vgagp-----FLPEISKSAKRIAVAVATGQYAVCTLLNYKVF.GTKTHYVRQLCVLTDELFRRLS..G.TMCLF.LN..PDE...R..ELIDKCSPLSICK.-KLSLN-YRAQKN.AVFFHPRFHVRAEEALKALYAKFCTCGDC..H.ESSCLT.NG---------------SDAA.AEPLRPR...LEDAELRLLNNTQLGRFHLPAIRHLSAAEQLRVQQSVARDLGF.TD.W.SNTL..VD---DYFLLPVGMSCG..-TPC...QGY....AMYLMSNAVLALKVIRLLYITVRHEQNACVRALCKDVNCLIKMFRCESFSIRK.GLA.............QNAA.............QRMEVSR.F.R--RHVQDLKQ....IKFTVETFVETFCEFIKIVNKIPDY...QYISIHVKRELVLLHLLKLRR--------------.....---.......-VYES..SSPET...RRAERLAWYYLRHGDVTLDPGLLMT-----------------FNSILADCELSNNANRCRRKAPLVIP----ATATVTVRYQGHLEKLSRLHVRRFRPHEV.....................................................
K7Y9Z1_RCMVE/155-551                  ....ln--RLEYRPEATDACRTLCRATVAVQYAISILYGYDRS.ASVPRYLRRLIDEYIDLQDRIR..RlGIVPV.LKisGKD...M..NIVQNVLPERVCAqIGIPFT----YEA.--CLLDEYYDCIESNIEQMYDLLCMCKEC..G.MRRMER.FERVRYNTIG-----ERYPKK.KRDRERF...FEENYVIIHSHPDLGVLKLPKIRHLNPLQQLMMCRYLSKDLLYdTQ.F.GPSN..AFSRAQGVPLPFSAVQE..TDMN...IAY....ALYLASNSYFMCFLLRCVRDVLRHEEEAFRKLILRLVNEAVEIIRDDVNSRVW.AGA.............DSPVfvcvdpresgisaEERDLAI.A.RSLEELTFS-N....ELVEGSHFGGFCRDAARFLDLIDAFhfpKALREHRAREDLLLHTFKIEKMYDNRPLSAYYGDR.....LVP.......-----..-----...-----------------------------------------------------------------------------------------------------yhvlmgghrrr..........................................
I3VQ05_9BETA/59-329                   ......IRNASFFSDADQETVSLAKIFCIGHYVKAYYAQYRGKrNTLIGYIRDLCKMANSMFCRLI..-.VLR-Y.MG..ERR...N..NANMRAVFDVLK-.--NPIDD-ETYGA.VAYSNDALYESYRVNLNYVSKILCNCAEC..Q.D-NIVS.RPLGRVLCVG-NPRPRMA--D.RGRGRSW...LGDKTVHLKGSASFPPMCLPDIGHLSDAQISVILEELSNDVMQ.--.-.--RH..VYSVMDAGQLPLRLDTT..SMGRdfmERN....TIMLIYNVTFTLFLLSSVRKLIRLELDLLKCAFVEEVSNL-------------.---.............----.............-------.-.-----------....-------------------------...-----------------------------------.....---.......-----..-----...-----------------------------------------------------------------------------------------------------rgcvann..............................................
A0A1P8VIS1_9BETA/50-410               .....l-NNAEFVPDFKPELQAISKLAVIILYSSMSLYNLKDK.ISLCYWCRYCAECLNVMFGKFH..D.TLKDL.ES..EDY...D..AASP---LLSLIK.-DNTFQYDPAERS.SLFFRYDFYQTMQDIYIECMMMMCGCDEC..R.RIFF--.NYKNKKNDEI-----------.--FMSVY...CDVFPE-------LGILELPILPHFGVYNMKHLKDQFKKDLCL.--.-.--SL..IYGQVKKRRFPLKFDFD..--PD...KINvyvdLLTMLGNIVFMLYVVNKIHAAVKKENSMYKEFVDTQVKVLVEWLQNCKTIGTI.GCF.............SDPF.............RSRLGKV.Y.STVKNTHIF--....-----DHIMDFLIPIVRNGMQLPDY...FNFKYRDMHIKFLKHVFDIERDFVLNCSDLIAADN.....LTH.......GYMLI..SS---...-----------------------------------------------------------------------------------------------------dvndvmtsvfngs........................................
#=GC seq_cons                         .........hpFhP-hocss+plshAsAsGQYulsoLhsY+sh.uohs+YlRpLCphsppLatRLc..s.sls.h.hc..scp...R..plltphhs.slCp..thslp.hpsp+s.slFFcscFhtcsEtsLpthYtthCsCs-C..+.c..h...t.ttth.shs................ps+...LEpsplhl.t..pLGth+LPsIRHLosspphplpptlu+DLsa....a.tpoh..l-...-hhhLPluhssu...ssc...cuY....shaLhSNhVhhLhlIphLttsl+pEhsshhchlsp-VppLhphhct-hthhpp.Ghh.............ps...............pttplsh.h.p..ccl+-l.t....h.hshssFltsht-hlclspplP-Y...psls.p.hpE.hhLHhhcl+R....................................st................................................................................................................................................................
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