#=GF ID   Herpes_UL37_2
#=GF AC   PF07413.17
#=GF DE   Betaherpesvirus immediate-early glycoprotein UL37
#=GF PI   Herpes_UL37; 
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_21151 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   29.80 31.60;
#=GF NC   24.80 23.60;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 90746521 --cpu 8 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8794367
#=GF RT   The human cytomegalovirus UL37 immediate-early regulatory
#=GF RT   protein is an integral membrane N-glycoprotein which traffics
#=GF RT   through the endoplasmic reticulum and Golgi apparatus. 
#=GF RA   Al-Barazi HO, Colberg-Poley AM; 
#=GF RL   J Virol 1996;70:7198-7208.
#=GF DR   INTERPRO; IPR010880;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Betaherpesvirus immediate-early
#=GF CC   glycoprotein UL37 sequences. The human cytomegalovirus (HCMV)
#=GF CC   UL37 immediate-early regulatory protein is a type I integral
#=GF CC   membrane N-glycoprotein which traffics through the ER and the
#=GF CC   Golgi network [1].
#=GF SQ   17
#=GS Q9DWF4_RCMVM/66-302      AC Q9DWF4.1
#=GS Q8QS51_9BETA/172-455     AC Q8QS51.1
#=GS G8XTA9_SCMVC/91-352      AC G8XTA9.1
#=GS U18_HHV6U/8-291          AC Q69553.1
#=GS I3VQ12_9BETA/89-313      AC I3VQ12.1
#=GS Q69500_HHV7J/11-294      AC Q69500.1
#=GS A0A7T7DGD8_9BETA/89-299  AC A0A7T7DGD8.1
#=GS VGLI_HCMVM/191-468       AC Q6SW94.1
#=GS A0A0K1GZT3_9BETA/1-243   AC A0A0K1GZT3.1
#=GS K7XW82_RCMVE/16-302      AC K7XW82.1
#=GS U18_HHV6Z/9-291          AC P0DXM1.1
#=GS VGLI_HCMVA/191-467       AC P16778.2
#=GS Q2FAQ8_RHCM6/101-358     AC Q2FAQ8.1
#=GS A0A1P8VIT3_9BETA/1-223   AC A0A1P8VIT3.1
#=GS A0A191S3V2_9BETA/12-295  AC A0A191S3V2.1
#=GS G8XSV1_9BETA/70-346      AC G8XSV1.1
#=GS Q91TQ6_TUHV1/87-349      AC Q91TQ6.1
Q9DWF4_RCMVM/66-302                 ....................................................wfgvvswwfvknvrhsshrelr-----------------------------------------------------------------.------------------------------.--AVKIGLAYYFSGYL-LRPLSS.....RvagslkwT....E.GNASHLG..GAATCWR...R..DG..T-TGGSVELNVTeT.E.R..YVLDV------RDGERN-ATWKGSGNR-.--------SEV..VGRILGTNVSLDVGVLLR-CGDI----VDAAV-----VGHA...SSNRR.SRNLRTS.VVRKE.PcvgaNVYLNWSAVWANWTK......--..--YG..EF.DEFC--YRDVAFHLSVRGREGGDRLANMTGMFIVATGAFALLALLCCMSMKQRRSILKDF.................................
Q8QS51_9BETA/172-455                ..................................................................lsacvltv----------HGVTAGCTYSAP-VNQTDRNGGFQNCKMNCTYNGTVIYCGPCLGAKKALQLNMTFpRKGNRHWHARMLNFGLR-------------.---------FHLEGLFPSWVLNQ.....S.......D....LkSNVSQVD..GAIFCNTsliD..RR..NITTGLLTLNLT.T.L.NigYVLRAA---S--NVDVT-RRHVYWNVTR.NDT--DNATDV..VKTVLSRHVESNYIFLQDVCPRLLRRFQRLNV-------SI...TNVTV.NG--GSN.NVTA-.-....--VWNDTESWGMWSK......LS..VMWK..NR.RVEF-----------LRSQSRALGHWAMISMFSATAGTLVILSLFCMVSFWRRRDLIEDF.................................
G8XTA9_SCMVC/91-352                 ...........................................................wilncqyrgnmsstm----------------------------------SCMLNCTYNGTSIYEGPCYLATTQLKLNMTF.RRSTRAWHNMVLRVGLQ-------------.---------YYLNGRIMHRLYVL.....S.......N....L.STVTPFV..GSLQCSR...N..AS..NHNETQGTIVLE.S.E.A..WGRNVLSVTSRDRRNLA-LAWTRENVTEfNGNVSETLAVI..VFNWLKVHAGTDRFFLSDVCLRL----LN---------RLK...KFTRS.PVKVTNE.NITD-.-....NI-TYGILEWPTWTQ......VT..QMWI..DA.NTSP------------RLSWCAWGIFSL---SAVVLAAVMLLGLFGGLVQRSRKHMQND-i................................
U18_HHV6U/8-291                     ................................................................slsvyifvmg--------------VCFTSNFT---CEQKIVLIQEHKLRSICISTCYVNGVLAGNSSCVSVKTSY.LINL-----AMLTNGFKAMRVGNITSISEK.TAFLRVIINYYFRGVM-LRALIA.....Q.......R....L.PNAANLS..STVNCWL...D..DH..S-AGGVMTLFYG.T.E.R..IVLNS-------STEINASRWISDGQDA.NGT--------..-LNILNERVSLDIYFLSKICPQLSSEIYKKKVAHPKYFSLI...KNDTK.PKKFLRN.TWRS-.-....--------AWSNWYK......--..--YK..EI.KEFLDFSSDYENFSEITYSMSAAGLFFL------AGGAFTMLLLLCCLSMITRKHIVKDL.................................
I3VQ12_9BETA/89-313                 ..............................................................lgtvngtirrav-----------------------------------------------------------------.------------------------------.----EVGLRYYTEGYA-LRGFLA.....S.......R....E.VTDKNVKaiSQFSCRS...E..QK..-VATGYLNLTLG.R.Y.K..YVLRL-GRNKPAASPV----WSSYGVED.DNK--------..IFSVLVPTTSYDRLFLRKGCLAM-ATHFKNGTSGRRAPRKM...FGCNG.ATEVLDE.NWRSM.W...lNWSKFEEINKTENVE......-S..IMVK..DM.YGAV--TPKRKPPKKKRLGSKLAGMFVI------CGGGLMFTVMFCGLAIRRRHNIVKDF.................................
Q69500_HHV7J/11-294                 .................................................................liclsltlm------------------SN---LKCHQNIIFLD-NKLEAVCVTTCYVNEMLIGNSSCLSVRTAF.LISL-----SLKTEGFREMSLVNLTTTSHK.LTYLRVLINYYFRGVM-LRALIA.....K.......K....W.HFASRAN..STLECWL...E..GH..N-SGGSITIMTG.G.Q.K..FLLQL-------RSGIVAVKWRSVGKDK.NKT--------..-LEILNQKFNYDCYFVAMICPHLSDEIYQRKVLNPN-FTIV...RNETI.YKRFLRK.TWKS-.-....--------SWLDWYKykeledLS..ASYG..G-.KNVI-FLNDYESFLDQT-QATTIGVVFL------VGGSAMVLFLFFCLSIVNRRKVD---knv..............................
A0A7T7DGD8_9BETA/89-299             .......................................................vhgwslecqyngevngtit-----------------------------------CELNCTYNYTLIYQGPCSLAITRLKLNVTL.LGKGRNWQHTLMRNGLQ-------------.---------YYFGGRIVQRFYLL.....S.......N....T.STVMPFT..GSLTCGL...NmsNE..NVTQGKILLYST.SwG.R..HVLNV---TSRWRWDAR-RTWHHETVN-.-AS--EPFATN..VSKWLDSHVGADRFFLSDICMRLFNRLKK------------...-----.-------.-----.-....---------------......--..----..--.------------------------------------------------------------fknstvnitnesctenityeilhwptlaeitqr
VGLI_HCMVM/191-468                  ..........................................................................GYGVSVRCTYHGTDINVTSNATSMNC----------RLNCTCNHTQIYNGPCAGAESKLPLNVTF.RQSRRQWHSVMLTFGFQ-------------.---------YHLEGWFPLRILNE.....S.......R....D.INVTEVY..GEVACFT...N..DT..NITMGQLTLNLT.G.R.S..YVLRALARTSPFESSVN---WEETNVTD.NATSSENNTVT..VMSVLTVYAESDYIFLQDMCPRF----LKRSV------KLA...KNNRR.NTTFTGT.NVTSL.P....EWTLQQCQGWKYWTT......LS..IMWK..NR.RSAL-----------LRAKSRALGHWALLSICTVAAGSIALLSLFCILLIGLRRDLLEDF.................................
A0A0K1GZT3_9BETA/1-243              .......................................................................mkc------------------------------------ELNCTYNGTLIYQGPCHLAVDKLRLNMTF.PKRRRVWHSMILNIGLQ-------------.---------YYLGGRIMYRLYML.....S.......N....L.--STSFT..GMLQCIC...N..DSsrNVTQGKIVLQSQ.AwG.Q..HVLSA---TSADRRNTN-CKWQQ----G.NSTEAENSTVKgyVSTWLEKHLDTDRYFLSDVCIRL---IYRLKK-----FEAS...PVNIT.DQDYADN.ATYG-.-....------VLEWPTWTQ......VM..QLWS..--.-------------SKVVSSKLTLCAWGLFSISSVALGAFILVALFAGFLGRSQRHIRAD-i................................
K7XW82_RCMVE/16-302                 qasmssnvpekltfecsydvclvhrkdgrvnigcvvtctygldvvfsgrcnegfnlvsnwfvkihrrlevrnlq-----------------------------------------------------------------.------------------------------.--ILKIGIAYYFAGYV-LRPLSLwpdliT.......H....S.HGKTSMG..GVARCWV...R..GA..E-SGGSVELKTH.T.QgA..YKLDV----EPGLRNIT---WTAED---.--T----NHAN..MLEFLQSNLSEDVYIFN-SCPKM---LYAVSIGHHSDG--S...PDLMK.RTAIIRR.DACAG.G....FVSDRWADIWKNWTK......YC..EFYE..DT.QRDPAFSIT------IKNSKLNNGTPNLIGMFVVVFGAFAMLALFCAMTIKQRKSIFKDF.................................
U18_HHV6Z/9-291                     .................................................................llvytfvmg--------------VCFTSNLT---CEQKIVLIQEQKLGAICISTCYVNGVLAGNSSCVSVRTSY.LINL-----AMLTDGFKAMKVGNITSISEK.TAFLRVIINYYFRGVM-LRALIA.....K.......R....L.PNAAQLS..STVNCWL...E..GH..S-AGGVMTLFYG.T.E.R..IVLKS-------STEMNASQWTSDGPDA.NGT--------..-LNILNERVSLDSYFLSMICPQLSDEIYKKKVVHSKYFSLI...KNDTM.PKKFLRN.TWKS-.-....--------AWTNWYK......--..--YK..EI.EALLDFSRDYENVSEITHSMSAAGLFFL------AGGAFTMLLLLCCLSMITRKHVVKDL.................................
VGLI_HCMVA/191-467                  ..........................................................................GHGVSVRCTYHGTDVNRTSNTTSMNC----------HLNCTRNHTQIYNGPCLGTEARLPLNVTF.NQSRRKWHSVMLKFGFQ-------------.---------YHLEGWFPLRVLNE.....S.......R....E.INVTEVH..GEVACFR...N..DT..NVTVGQLTLNFT.G.H.S..YVLRAIAHTSPFESYVR---WEETNVTD.NATSSE-NTTT..VMSTLTKYAESDYIFLQDMCPRF----LKRTV------KLT...RNKTKhNVTVTGN.NMTTL.P....VWTP-ECKGWTYWTT......LS..VMWR..NR.RSAL-----------LRAKSRALGHWALLSICTVAAGSIALLSLFCILLIGLRRDLLEDF.................................
Q2FAQ8_RHCM6/101-358                ..........................................................glslecqyggdvndtm------------------------K----------CELNCTYNGTLIYQGPCHLAVNKLRLNMTF.PKRRRVWHSMILNIGLQ-------------.---------YYVGGRIMYRLYML.....S.......N....L.--STSFT..GMLQCIC...N..DSsrNVTQGKIVLQSQ.AwG.Q..HVLSA---TSADRRNTN-CKWQQ----G.NSTEAENSTVKgyVSTWLERHLDTDRYFLSDVCIRL---IYRLKK-----FEAS...PVNIT.DQDYADN.TTYG-.-....------VLEWPTWTQ......VM..QLWS..SR.---------------VVSSKLTLCAWGLFSISSVALGAFILVALFAGFLGRSQRHIRAD-i................................
A0A1P8VIT3_9BETA/1-223              .....................................................................mtnsk-----------------------------------------------------------------.--------------NFNTLNFPNVTTKDEK.NILAKIFITYYFRGIL-IKAILS.....-.......-....R.TNKTHLI..SKFECWS...D..EY..E-KGGNIQIISG.K.D.N..FSFFT-------NDNLN--RWKG--PKN.NE---------..ILALVNIDYNLDEIFLKYYCPDLADELQRRKLTENEYLKII...KNVPI.NRKKVSK.SWIT-.-....--------SWLGWYK......YKeyYVFKvtQV.DETISF-NDYDESIEDTESMNTAGTFFL------LIGSLVLLGLFVTLIIMRRRDVSK--am...............................
A0A191S3V2_9BETA/12-295             .................................................................lkisfvyms----------------------NLKCIQKIIFL-EDNFEAICISTCFINDQIIGNSSCLAVRTAF.LITL-----ALKTEGFQNMNLVNVTTFTRK.TTYLRVFINYYFRGVM-LRALIA.....K.......K....W.SSLSQVH..SILECWL...E..GQ..N-SGGSITITAG.K.Q.K..FVLQL-------KSGMVVTRWKTTGKDT.NKT--------..-LEILNQKFNYDCYFVSMICPQLSDEIYQRKIINPD-FTLM...RNETI.HKRFLRK.TWKS-.-....SWI--SWFKYKELEE......LS..ASYG..TG.N--IIYLDDYENVLDITQSTTATSLVFL------VGGATMVLFLLCCLSIVTRRKVSK--et...............................
G8XSV1_9BETA/70-346                 ............mcvtldcelrtclqrtgylttsgcvldcvfnhslvyrgpcdevfqimrwnisfprkdtrdiq-----------------------------------------------------------------.------------------------------.STILNLGLRYYLEGHV-LAHVTA.....N.......L....H.LKSSKLSvvEHLVCTK...D..ED..GMVNGTMSLNWG.L.Q.G..IYNFSSVTNRTYDT--NKDVWTSPSKNR.QKT-----HNT..IVSFLNQEAENDFEFLKEVCHRLVNKRMKK------YIVVIgrrVNRLK.NEQVC--.RMRSI.P...vDW----HVPWINWTK......FT..VIPK..MR.WTVL---VDTELV-RNRVILTTI------GMCILGSGMFLMLGMFFMVILWRRHDLISDL.................................
Q91TQ6_TUHV1/87-349                 ........................................ngktsfrcsiecyfnatlvyvgdcgmarddllwn-----------------------------------------------------------------.-------------------RVSSQSSMNDGvAASLDLGLHYYMDGYL-IRGIVA.....R.......TgwaaS.PGVTWFS..GRLFCWR...N..DT..L--GGQIGFNFS.D.S.Y..YTF-SVHFIEGYKEEVH--KWVRRSGRQ.QTL--------..VEQLLFEGAYHDDNFLRTACPKLVRRIGNR-V------ERL...KSNLP.ESRAARTcGGRSLvP....GWT----RLWANWTK......YS..EMAL..TTgRRAY-VIGDYDVGDRPGKK---LQLSKLLGLFAVIGGTLMMTVLFCVLSLLRRREIVRDL.................................
#=GC seq_cons                       ..................................................................h..hh.hh.....................................htshh..T.hhpt.h.hs.ttl.lphsh...t.......hhp.Ghp.......................YYhcGhh.lRslht.....p.......p....h..ssophs..uplpChp...s..sp..s.ssGplsLphs.s.p.p..aVLps....p..csshs..pWpp.s.pt.NsT..........lhshLspcsshDhhFLpchCs+L...hh+tpl......phh...psshh.spphhpp.shpu...............tWhsWsc......hp...hap..ph.pt.h...........hptp.pshuhhhL......ssGuhhhLsLFssl.hhpR+clhcD..................................
//