#=GF ID Herpes_gE_N
#=GF AC PF20418.1
#=GF DE Alphaherpesvirus glycoprotein E N-terminal
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE PF02480
#=GF GA 24.50 24.50;
#=GF TC 24.50 24.80;
#=GF NC 24.40 22.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 10881679
#=GF RT Epitopes on glycoprotein E and on the glycoprotein
#=GF RT E/glycoprotein I complex of bovine herpesvirus 1 are expressed
#=GF RT by all of 222 isolates and 11 vaccine strains.
#=GF RA Rijsewijk FA, Kaashoek MJ, Langeveld JP, Maris-Veldhuis MA,
#=GF RA Magdalena J, Verschuren SB, Meloen RH, van Oirschot JT;
#=GF RL Arch Virol 2000;145:921-936.
#=GF RN [2]
#=GF RM 16646632
#=GF RT Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a
#=GF RT mechanism for antibody bipolar bridging.
#=GF RA Sprague ER, Wang C, Baker D, Bjorkman PJ;
#=GF RL PLoS Biol. 2006;4:e148.
#=GF RN [3]
#=GF RM 11689673
#=GF RT An N-terminal domain of herpes simplex virus type Ig E is
#=GF RT capable of forming stable complexes with gI.
#=GF RA Rizvi SM, Raghavan M;
#=GF RL J Virol. 2001;75:11897-11901.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Glycoprotein E (gE) of Alphaherpesvirus forms a complex with
#=GF CC glycoprotein I (gI) (Pfam:PF01688), functioning as an
#=GF CC immunoglobulin G (IgG) Fc binding protein. gE is involved in
#=GF CC virus spread but is not essential for propagation [1]. This
#=GF CC entry represents the N-terminal domain of gE, which interacts
#=GF CC with gI [2,3].
#=GF SQ 22
#=GS A0A455JP06_9ALPH/69-187 AC A0A455JP06.1
#=GS K9MG68_9ALPH/38-164 AC K9MG68.1
#=GS A0A1R3TEQ0_9ALPH/34-171 AC A0A1R3TEQ0.1
#=GS Q69288_9ALPH/33-164 AC Q69288.1
#=GS A7U881_HHV2/40-164 AC A7U881.1
#=GS A0A060Q505_9ALPH/41-158 AC A0A060Q505.1
#=GS GE_CHV1/41-169 AC P30816.2
#=GS GE_PSHV1/39-187 AC Q6UDF4.1
#=GS GE_HHV2H/38-161 AC P89475.1
#=GS Q77LR5_CHV9D/169-304 AC Q77LR5.1
#=GS GE_EHV1B/42-170 AC Q6S6V7.1
#=GS Q77L56_MEHV1/34-164 AC Q77L56.1
#=GS GE_VZVD/183-321 AC P09259.1
#=GS GE_HHV11/40-163 AC P04488.1
#=GS A0A077B9G3_9ALPH/43-171 AC A0A077B9G3.1
#=GS A0A0B5LBJ9_9ALPH/53-184 AC A0A0B5LBJ9.1
#=GS GE_GAHVM/33-164 AC Q77MP7.1
#=GS C6ZD38_9ALPH/35-174 AC C6ZD38.1
#=GS A0A0Y0DAC9_9ALPH/35-156 AC A0A0Y0DAC9.1
#=GS Q5Y0N5_9ALPH/41-163 AC Q5Y0N5.1
#=GS A0A1C3J7M7_HHV1/40-163 AC A0A1C3J7M7.1
#=GS J9QWN5_9ALPH/39-154 AC J9QWN5.1
A0A455JP06_9ALPH/69-187 papgpdaravrg--------.....----..-----WSRL..-.ASACPPPGPA.tEVCIDGHQCFADVVV...DAACL...................PT.VsL.EPLAVAEL-...-SGGGGA.GR.LADLAERRVFA...qLDY......NETGVWIPNATAADAGVYFLY...DRRL--.--------------geaggeethsa....
K9MG68_9ALPH/38-164 ...........l-LPAPTGQ....gERIR..AHKLLWAAE..P.LDACGPLRPS..WVALWPPRRVLETVV...DAACM...................-R.A.P.EPLAIAYSP...PFPTGNG.GL.YSELAWHDRVA....--V......VNESLVIYGAREADSGLYTLS...VVGLSD.EARQVASVVLVVEP...............
A0A1R3TEQ0_9ALPH/34-171 ...idipiqnrt-------R.....ITGRykNYTEMWSFV..W.TGSCKTLEKR..YICENVRECFDDLVI...GNGCDy.................hNH.I.D.LPLGVAYFR...VNGNGSL.NL.LEDVYFTN--G....TDIlpimttTGRGLRINNATVGHTGIYTLS...YRFDS-.--------------gdwfsshvfltvkk.
Q69288_9ALPH/33-164 ............TTTIP--Ryp.pvVDGT..LYTETWTWI..P.NHCNE-TATG..YVCLESAHCFTDLIL...GVSCM...................RY.A.D.E--IVLRT-...DKFIVDA.GS.IKQIESLSLNG...vPNIfl.stkASNKLEILNASLQNAGIY-IR...YSRNGT.RTAKLDVVVVGVLG...............
A7U881_HHV2/40-164 ........papa---GPEER.....--TR..AHKLLWAAE..P.LDACGPLRPS..WVALWPPRRVLETVV...DAACM...................-R.A.P.EPLAIAYSP...PFPAGDE.GL.YSELAWRDRVA....--V......VNESLVIYGALETDSGLYTLS...VVGLSD.EARQVASVVLVVEP...............
A0A060Q505_9ALPH/41-158 .iaipshglqdp--------.....---P..VSKLVWGYA..G.TSRCGMVQPI..WVAIHPPRRVKVAVI...EPDCM...................-D.N.P.SVLAIQYT-...------R.GH.SQVFPMNVTSP...rLTI......DGHTLLLHDVRQTDSGLYTLT...G-----.--------------itspegrpwqqdvfl
GE_CHV1/41-169 .........lfa---LPAAR.....PGAP..PAKVVWELD..P.MAACGSLRPS..WVSLRPPGQVLDTVV...DAECV...................--.-.S.EPVLLAAW-...-YERRDG.GSeVPAPFWGPDGAppqrGNV......TNGTLVLREARVGDSGMHVLS...VFHPPN.ATAARHVVFLKV--ap.............
GE_PSHV1/39-187 ............LLFGPSLRrt.lpAGG-..--TFKWV--..-.LVLSDPCAPKptEICVSVGHCFYDLVSsdnDSECAnkdrrvltlalltksktgeLR.V.I.GPMAAS---...SALVGDA.GE.LEQLRRRVSAG...mGLT......DDGDISFAAADKVNEGLYGVR...VMGSGD.SYTFFNVTVATETA...............
GE_HHV2H/38-161 ............LLPAPAER.....--TR..AHKLLWAAE..P.LDACGPLRPS..WVALWPPRRVLETVV...DAACM...................-R.A.P.EPLAIAYSP...PFPAGDE.GL.YSELAWRDRVA....--V......VNESLVIYGALETDSGLYTLS...VVGLSD.EARQVASVVLVVEP...............
Q77LR5_CHV9D/169-304 .........kvh---IPQEN.....--EH..TYTERWSFL..P.AAPCKLTPPSiqQVCIKHGACIHDVVV...DVDCIaesmeht.....lveigyvV-.-.-.------HASk.aVHPTWTVvNI.TEDFANYGFDT....PDV......KPGVLKFEHMNAHHAGVY-IW...NLQGTH.GENMYVTFLVK---lnn............
GE_EHV1B/42-170 ......vltptn-------T.....--TT..RVTKAWTFLetP.PGCAGDISVK..KVCVSHSLCEDNIII...GKHCN...................LL.T.G.EHGIAL---...AEFNVVN.GS.LRRTDDVYFVN....GTVfpilaeTRSVLQIHRATPSIAGVYTLH...VS--ID.GMMKHSVVLLTVK-k..............
Q77L56_MEHV1/34-164 ...vdipryppl--------.....TNGT..IYTETWTWI..S.SICND-TSMG..YICLDRATCFQDLLL...GTSCV...................RY.G.E.E--KILRV-...DRFVVNS.GS.LDRIASSQFHY...iPNVii.gtgRGKELTIFNATSQIAGVY-TR...YTRNDS.RPAVMDVLLVWV--sv.............
GE_VZVD/183-321 ............TLRAPIQR.....IYGV..RYTETWSFL..PsLTCTGDAAPAiqHICLKHTTCFQDVVV...DVDCAentkedqla.eisyrfqgkKE.A.D.QPWIVVNTStlfDELELDP.PE.IE---------....PGV......----LKVLRTEKQYLGVY-IW...NMRGSD.GTSTYATFLVTWKG...............
GE_HHV11/40-163 ...........p-APGPTGR.....--GP..TQKLLWAVE..P.LDGCGPLHPS..WVSLMPPKQVPETVV...DAACM...................-R.A.P.VPLAMAYAP...PAPSATG.GL.RTDFVWQERAA....--V......VNRSLVIHGVRETDSGLYTLS...VGDIKD.PARQVASVVLVVQP...............
A0A077B9G3_9ALPH/43-171 lgvpdngtsrvl--------.....----..---KAWTFLetP.RGCAGDVSVS..KVCVSRALCDEEIVV...GQRCN...................LQtI.E.RPLALA---...-EFTAAA.GA.LARVRDAYFVN....GTVfpilteTRSGLRIAGATTNLTGVYTLH...A-SLDD.RQEHYAFLIT----vkk............
A0A0B5LBJ9_9ALPH/53-184 ...........f-LPGPAAR.....-PDV..RAVRGWSVL..A.-GACSPPVPE..PVCLDDRECFTDVAL...DAACL...................RT.A.RvAPLAIAELA...ERPDSTG.DK.EFVLADPHVSA...qLGR......NATGVLIAAAAEEDGGVYFLYdrlIGDAGD.EETQLALTLQVA--ta.............
GE_GAHVM/33-164 ............TTTIP--Ryp.pvVDGT..LYTETWTWI..P.NHCNE-TATG..YVCLESAHCFTDLIL...GVSCM...................RY.A.D.E--IVLRT-...DKFIVDA.GS.IKQIESLSLNG...vPNIfl.stkASNKLEILNASLQNAGIY-IR...YSRNGT.RTAKLDVVVVGVLG...............
C6ZD38_9ALPH/35-174 ........vtle----PKIRdklptIVGS..RFKEAWSFT..K.TTECKAVAPA..YICLDTIYCFSDLVM...DKDCDy.................hGH.M.T.VPLGIAYYTv.hENSALTE.LD.HAYF-TRDSNV...yPILg....aNIRGVKITNSTEANEGLY-LL...HARINDsSYFRTEVFLLTL--kd.............
A0A0Y0DAC9_9ALPH/35-156 ....vllfphqs--------.....MSQP..EEKRVLSFI..P.LNRCALHHPQ..WVSIRPRHNLLDMTL...SSKCV...................-E.P.P.TALMVQYT-...-DLTRDN.PT.VT--VHHNRIT....--F......EDDAISLKNIQASDTGLYTLI...STTDPT.RAHEE---------siflhvvpp......
Q5Y0N5_9ALPH/41-163 .........fdl----PAGR.....PGGP..PRELAWEFA..S.MRNCGPLRPS..WVSLHPPGQVLETVV...DAQCV...................-G.A.P.RLMAAWYGR...PDGAPAP.GP.--EAAWPPRVS....--V......SNGTLTLREARPSDSGMYVLT...VSRAPN.STAARRVVFLTV--gp.............
A0A1C3J7M7_HHV1/40-163 ...........p-APGPTGR.....--GP..TQKLLWAVE..P.LDGCGPLHPS..WVSLMPPKQVPETVV...DAACI...................-R.A.P.VPLAMAYAP...PAPSATG.GL.RTDFVWQERAA....--V......VNRSLVIHGVRETDSGLYTLS...VGDIKD.PARQVASVVLVVQP...............
J9QWN5_9ALPH/39-154 ...teevlaadn--------.....----..-RSLAWAFG..P.LSACGPLRPV..RVMLSAKTHRLDTVV...PDWCA...................--.-.-.EPPVLLWVE...RDHGGGR.GG.RA---LAELDG....LLI......DNSSLVLERAGGAHAGVYTLL...SRA-PN.GSEETA--------svfvdig........
#=GC seq_cons ................P..p.......s...hhphhWuhh..P.hssCushpPu..aVsLpsspphh-hVl...-ssCh....................p.s.s.pPhslths....sp.ssss.Gt.hpphh.tphsu......l......sspsLhItsAptscuGlYsLp...shp.ss.tttphsshllhh.................
//
