#=GF ID Herpes_gI
#=GF AC PF01688.24
#=GF DE Alphaherpesvirus glycoprotein I
#=GF AU Bashton M;0000-0002-6847-1525
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_1222 (release 4.1)
#=GF GA 27.00 27.00;
#=GF TC 27.00 56.80;
#=GF NC 26.90 21.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0159
#=GF RN [1]
#=GF RM 8764058
#=GF RT Biosynthesis of glycoproteins E and I of feline herpesvirus:
#=GF RT gE-gI interaction is required for intracellular transport.
#=GF RA Mijnes JD, van der Horst LM, van Anken E, Horzinek MC, Rottier
#=GF RA PJ, de Groot RJ;
#=GF RL J Virol 1996;70:5466-5475.
#=GF RN [2]
#=GF RM 8207390
#=GF RT Identification of the feline herpesvirus type 1 (FHV-1) genes
#=GF RT encoding glycoproteins G, D, I and E: expression of FHV-1
#=GF RT glycoprotein D in vaccinia and raccoon poxviruses.
#=GF RA Spatz SJ, Rota PA, Maes RK;
#=GF RL J Gen Virol 1994;75:1235-1244.
#=GF RN [3]
#=GF RM 8207795
#=GF RT Unusual phosphorylation sequence in the gpIV (gI) component of
#=GF RT the varicella-zoster virus gpI-gpIV glycoprotein complex (VZV
#=GF RT gE-gI complex).
#=GF RA Yao Z, Grose C;
#=GF RL J Virol 1994;68:4204-4211.
#=GF DR INTERPRO; IPR002874;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family consists of glycoprotein I form various members of
#=GF CC the alphaherpesvirinae these include herpesvirus,
#=GF CC varicella-zoster virus and pseudorabies virus. Glycoprotein I
#=GF CC (gI) is important during natural infection, mutants lacking gI
#=GF CC produce smaller lesions at the site of infection and show
#=GF CC reduced neuronal spread [1]. gI forms a heterodimeric complex
#=GF CC with gE; this complex displays Fc receptor activity (binds to
#=GF CC the Fc region of immunoglobulin) [1]. Glycoproteins are also
#=GF CC important in the production of virus-neutralising antibodies
#=GF CC and cell mediated immunity [2]. The alphaherpesvirinae have a
#=GF CC dsDNA gnome and have no RNA stage during viral replication.
#=GF SQ 26
#=GS Q76PF0_9ALPH/1-164 AC Q76PF0.1
#=GS GI_HHV11/8-165 AC P06487.1
#=GS A0A5B9R003_9ALPH/4-157 AC A0A5B9R003.1
#=GS Q7T5C2_CHV1E/7-164 AC Q7T5C2.1
#=GS A0A7T1L7Q6_9ALPH/5-165 AC A0A7T1L7Q6.1
#=GS E1U2A6_9ALPH/7-163 AC E1U2A6.1
#=GS GI_VZVD/7-164 AC P09258.1
#=GS A0A1R3TFR9_9ALPH/3-157 AC A0A1R3TFR9.1
#=GS E2IUH9_SHV1/4-178 AC E2IUH9.1
#=GS Q5PP77_SUHV/14-164 AC Q5PP77.1
#=GS Q67645_ILTV/7-161 AC Q67645.1
#=GS A0A7L7YSD4_9ALPH/7-176 AC A0A7L7YSD4.1
#=GS J9QYR2_9ALPH/22-182 AC J9QYR2.1
#=GS GI_GAHVM/2-157 AC Q9E6L5.1
#=GS Q86789_FHV1/3-159 AC Q86789.2
#=GS A0A5P9JX79_9ALPH/3-140 AC A0A5P9JX79.1
#=GS GI_PSHV1/7-159 AC Q6UDF5.1
#=GS GI_EHV1B/10-162 AC Q6DLD8.1
#=GS A0A060Q0X8_9ALPH/3-175 AC A0A060Q0X8.1
#=GS GI_HHV2H/8-165 AC P13291.1
#=GS Q77L57_MEHV1/10-167 AC Q77L57.1
#=GS A0A172DSF1_9ALPH/2-151 AC A0A172DSF1.1
#=GS A0A286MM86_9ALPH/5-163 AC A0A286MM86.1
#=GS Q77LR6_CHV9D/13-168 AC Q77LR6.1
#=GS A0A7S9YU43_9ALPH/6-164 AC A0A7S9YU43.1
#=GS A0A1V0M8P4_9ALPH/13-167 AC A0A1V0M8P4.1
Q76PF0_9ALPH/1-164 .............mrc----LLLWMVVLAaraaparSLVYRGEAVGLRADGPVAFAVHPT...........DATLA-.-........LRGRLIFLEHQLPAGRRYNGTVELLRYH.AAGDCFVMLQTTAFASC............PRVANDAFRSCLHADTR-...P.....ARS.ERRAS..AAVEnhvLFSIAHPRPIDSGLYFLRVGIY-----.--------ggtagserrrdvfpla
GI_HHV11/8-165 ...............g-LVLVGLWVCAT-.......SLVVRGPTVSLVSNSFVDAGALGP...........DGVVEE.Dl......lILGELRFVGDQVPHTTYYDGGVELWHYP.MGHKCPRVVHVVTVTAC............PRRPAVAFALCRATDSTHspaY.....PTL.ELNLA..QQP-...LLRVQRATRDYAGVYVLRVWVGDAPNA.SLFVLGMA................
A0A5B9R003_9ALPH/4-157 .....vavyvisfacc------LLISRCY.......GIIVKGSFVSGVFEENIVVLGG--...........---GDQ.K........IGARLLFLGPQRPL-KPYGGGLRVFYQAsNSPGCFQKVFQQTFENC............TFSSPTVFTGCMNVSTK-...T.....SVS.WISRS..NEPG...QVILRSPTTYDSGSFYFAVLLDYGSHP.DAFKVK--fn..............
Q7T5C2_CHV1E/7-164 ..............fl--LALGPWALVA-.......GVVIRGPTISLVSDSLLAAGAVGA...........NGSFLE.Dl......eVPGELHFLGPQVPHVTYYDGSVELLHYP.PGARCPRAVLVEEMTAC............PRRNAVAFTLCRSTRRAQspaY.....ADL.TLDPT..RQP-...LLRARGPANAVVGFYVLRVWVEGATNA.SLFPLS--lv..............
A0A7T1L7Q6_9ALPH/5-165 ........aalvtlac-------LLSRAC.......SVVLRGSSVSLTTNRPFDVGVASD..........sEMTVPG.Dl......tVPGKLFFMGRQMPSAKYYDGTLELIHKP.DDGSCAKLVYVGEFTAC............PRRSTEAFVLCRELRFAQspsY.....PGL.SLDPA..HGT-...LLRVRNADPLYSGTYTLKVWLEGAANA.SVFPMT--lr..............
E1U2A6_9ALPH/7-163 ......ililvsainc--------ITTIN.......AIVYAGTSVSLYLQEPASASIPAV...........EDRHA-.-........VYGKLLFLGSQAELPPVYNGTVELLVYN.ISRHCYSVAYAAIYDDC............PRLGATAFKACR--HATR...YfdparPHL.KDVLS..STA-...LFVLDSPSIHDSGIYYIRVSVNDAVVP.DVFKTTV-i...............
GI_VZVD/7-164 ...............l-ISAVIFYIQVTN.......ALIFKGDHVSLQVNSSLTSILIPMq.........nDNYTE-.-........IKGQLVFIGEQLPTGTNYSGTLELLYAD.TVAFCFRSVQVIRYDGC............PRIRTSAFISCRYKHSWH...Y.....GNS.TDRIS..TEPDagvMLKITKPGINDAGVYVLLVRLDHSRST.DGFILGVN................
A0A1R3TFR9_9ALPH/3-157 ..............il-LAIVLSLVGLSD.......SIVFSGISVSLKSETPVLTAI---...........KSFETEiD........VGGKLMFLENQSNVSSGYGGVVELIHYD.LSKDCFRVIAKANYSDC............HRRSSYVFRGCRRKTSY-...Y.....SEDySIELK..LTGN..kLFTIKNPVNSYSGIFYLKVGFSHSNFS.DVFRTSI-i...............
E2IUH9_SHV1/4-178 ...lllllamlaccvp------------Rr....vsGLVLRGKAVSFYVEIAADAGVVGL...........SGVASD.Dl......eAGGGLLFLSDQVPAGAPYSGSVELLHRP.TPDACPRVVAIRRLSACavnggerealsePGSAVIAFSGCA-SDLTT...A.....SVA.YASLE..AFPNgayGLRLRNATVEYAGVHALRVWLNDAPEP.DEFVLTI-e...............
Q5PP77_SUHV/14-164 ......glllaaltla----------ALTpr...vgGVLFRGAGVSVHVAGSAVLV--PG...........DA-PNL.T........IDGTLLFLEGPSPS--NYSGRVELLRLD.PKRACYTREYAAEYDLC............PRVHHEAFRGCLRKREPL...A.....RRA.SAAVE..ARR-...LLFVSRPAPPDAGSYVLRVRVNGT--T.DLFVLT--al..............
Q67645_ILTV/7-161 .tlallaatlapfgam-------------.......GIVITGNHVSARIDDDHIVIV-AP...........RPEAT-.-........IQLQLFFMPGQRPH-KPYSGTVRVAFRSdITNQCYQELSEERFENC............THRSSSVFVGCKVTEYTF...S.....ASN.RLTGP..PHPF...KLTIRNPRPNDSGMFYVIVRLDDTKEPiDVFAIQ--ls..............
A0A7L7YSD4_9ALPH/7-176 .............glv--VLVGVVFQAT-.......GLIIRGPTISMITDSTMDVGIVDPnts....ptdsQSMN--.SfadttdltVSNTLYFLGTQVPKPTFYGGSLEITHHP.VDGSCPRVAYIATWSKC............PRRNAGVFTLCRSVHAVQspaY.....PKL.TVSVD..DSV-...RLHLRQAPIEYSGAYSLRIWIDGTTQS.NLFWVG--ft..............
J9QYR2_9ALPH/22-182 .........livaagv------MMMCRVY.......GIVLRGHSVSLASDRLFDVWPESAg.........rDAPE-R.Dl......tIPGELFFVGGQVPSQKYYDGVVELFHEP.SDGSCDRLVYVGKFAAC............PRRPYEAFVLCRDLREDRspaY.....PGL.SLELA..GGT-...LLRVRHASPWYAGTYRLRAWVAGAKNA.SVFPMT--lg..............
GI_GAHVM/2-157 ................YLLQLLFWIRLFRg....iwSIVYTGTSVTLSTDQSALVAFCGL...........DKMVN-.-........VRGQLLFLGDQTRT-SSYTGTTEILKWD.EEYKCYSVLHATSYMDC............PAIDATVFRGCR--DAVV...Y.....AQP.HDRVQ..PFPEkgtLLRIVEPRVSDTGSYYIRVALAGRNMS.DIFRMAVI................
Q86789_FHV1/3-159 .........siafiyi-----LMAIGTVY.......GIVYRGDHVSLHVDTSSGFVIYPT...........--LENF.T........IYGHLIFLDDQPLPVNNYNGTLEIIHYN.HHSSCYKIVQVIEYSSC............PRVRNNAFRSCLHKTSMH..qY.....DQL.SINTS..VETG..mLLTITSPKMEDGGIYALRVRFNHNNKA.DVFGLSV-f...............
A0A5P9JX79_9ALPH/3-140 ..........scllfv-------------.......-----GHKVSFKLTDAYPII-YSP...........QSTLT-.-........LTYDL-FFTSGLPR-RPYSGFVRVHTVP.RDSDCLIQISEKVYKGC............LGRSVVVFSNCT--QSWH...Y.....FNS.RNRVIgpASPT...SLVIQSPGVTDSGVYYISVSIDMGTSV.DVFEIPV-s...............
GI_PSHV1/7-159 ..............sq--AAVAIFLALVTc....clGTVIKGLGVSGVFEDTLVVF----...........EKVETE.D........VGARLVFLGDQRPK-NPYGGTVRVLFQPgESGTCSIPLLQVRYSNC............TNTSAAVFSGCYRTDTE-...F.....SVP.RANRG..TSPG...FVSLRTPTMLDSGDIYVTVHLDHLPRP.DAFRIK--fv..............
GI_EHV1B/10-162 ............aail----LSMAICST-.......AIIYRGEHMSMYLNASSEFAVYPT...........DQSLV-.-........LVGHLLFLDGQRLPTTNYSGLIELIHYN.YSSVCYTVIQTISYESC............PRVANNAFRSCLHKTSKHyhdY.....FRV.NASVE..TNV-...LLNITKPQPTDSGAYILRVKLDHAPTA.DVFG----vsa.............
A0A060Q0X8_9ALPH/3-175 lglvvfilssvgiaig-------------.......ELVLRGPTISMVAEKPIDAGFIHPfshnesqtrssAPYVLE.Dl......tVSGALYFLGSQVPKTPFYNGSLDILHVP.TGPWCPRVVYVASWLKC............PRRNSGAFTVCQSSHVTQskaY.....PSL.SVKVA..EQF-...VLRLTQASSFYSGVYVVRVWVGPESLP.NEFPL---tfv.............
GI_HHV2H/8-165 ...............g-LAILGLWVCAT-.......GLVVRGPTVSLVSDSLVDAGAVGP...........QGFVEE.Dl......rVFGELHFVGAQVPHTNYYDGIIELFHYP.LGNHCPRVVHVVTLTAC............PRRPAVAFTLCRSTHHAHspaY.....PTL.ELGLA..RQP-...LLRVRTATRDYAGLYVLRVWVGSATNA.SRFVLGVA................
Q77L57_MEHV1/10-167 .............vcv---TLILFCIIIKt.....qCMVYRGSLVSTTVDQSAQIAFFGI...........DTVVN-.-........LYGKVLFMGDQYLE-EIYSGTMEILKWN.QANRCYSIAHATYYADC............PIISSTVFRGCR--DAVV...Y.....TRP.HSRIH..PQYRnglLLTIIEPRMEDSGIYYIRTSIDGFNKS.DYA-----rtsifvcn........
A0A172DSF1_9ALPH/2-151 ..............fl--PILFLFLYGVN.......GFVYKGTYISMFLNTSSGFSIFPD...........DKFIV-.-........-SGRLLFLDDQHLSVNNYSGTIEFIHFN.--NSCYTVYQTIEYFSC............PRIFNNAFRSCLKKVSKH..hE.....SQL.RINSS..IENG..vLLEITNPKPNDSGVYFIRVQLEN-NKT.DVFG----ipa.............
A0A286MM86_9ALPH/5-163 .............alv---ALLAWALRTPgp...geAVVYKGNHTSLFLNRSVVTA-FRP...........DGADL-.A........VPGRLLFLGEQRPP-QLYNGTVELFFSPqPQHPCYAAVQLVVYTGC............PRIADDVFRSCLHVSSYH...A.....PWM.H-NVN..VSSDarsVLRIADPGAGDSGRYTLRVRTTGS---.--------gagydlfdvyv.....
Q77LR6_CHV9D/13-168 .............ylm--VFMLFGIQCAA.......AIIYRGNYISLYVNSSATSIFLKG...........NNNDA-.S........IRGRFLFIGDQFPVTNTYNVTVELLHVN.QTTLCLQPLYRVMYGEC............PRIRTGAIIACRVKRSWH...Y.....ENA.TQLTD..PNVE..iIFKMNNTKVEDAGIYLLVVQLDYTSLF.DIFFVS--ln..............
A0A7S9YU43_9ALPH/6-164 ........llaacalv--------LALAAgr...arAIIYRGTHVSMYLNASSEFAVYPG...........TERLE-.-........IAGHLLFLKDQRLPVNNYSGVVEVIYYN.YTNLCYRVLQTIEYESC............PRVANNAFRSCLHKVSRH...H.....HDD.PLRVN..VSAEtnvLLHIARPRPGDSGLYVLRVRLGHNAEA.DVFG----vya.............
A0A1V0M8P4_9ALPH/13-167 .............tiv---LLTTLLCLLRp....sqGLVFGGRSVSMYLEQTIVYGVQGE...........DKTIA-.-........IGGQILFL-DHYPS-GTYNGTFEIIKFI.QTDKCVQVLLAVEYKDC............PLLGSTVFRACR--HTEM...Y.....TLS.HSRMR..SDVVrgtVFMIDFPIKEDSGVYYIRVKLSGQNGS.DIFRVR--tl..............
#=GC seq_cons .............hhs......hhhths........ulVh+GspVShhsssshssuhhss...........cshhs...........lsGcLlFLusQhPpsssYsGolEll+hs..sspChpllhsspassC............PRhsssAFpuCpptcstp...Y.....sp..phpls..sps....lLplppPsspDSGhYhLRVtlssssps.DlFhht..h...............
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