#=GF ID HhH-GPD
#=GF AC PF00730.29
#=GF DE HhH-GPD superfamily base excision DNA repair protein
#=GF PI Endonuclease_3;
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_854 (release 2.1)
#=GF GA 26.20 26.20;
#=GF TC 26.20 26.20;
#=GF NC 26.10 26.10;
#=GF BM hmmbuild --handHMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0198
#=GF NE PF00633;
#=GF NL P78549.2/198-230
#=GF RN [1]
#=GF RM 10499592
#=GF RT The thymine glycosylase MBD4 can bind to the product of
#=GF RT deamination at methylated CpG sites.
#=GF RA Hendrich B, Hardeland U, Ng HH, Jiricny J, Bird A;
#=GF RL Nature 1999;401:301-304.
#=GF RN [2]
#=GF RM 10706276
#=GF RT Structural basis for recognition and repair of the endogenous
#=GF RT mutagen 8-oxoguanine in DNA.
#=GF RA Bruner SD, Norman DP, Verdine GL;
#=GF RL Nature 2000;403:859-866.
#=GF DR INTERPRO; IPR003265;
#=GF DR PROSITE; PDOC00615;
#=GF DC This entry corresponds to Endonuclease III
#=GF DR PROSITE; PDOC00447;
#=GF DC This entry corresponds to Alkylbase DNA glycosidase
#=GF DR SCOP; 2abk; fa;
#=GF DR HOMSTRAD; Endonuclease_3;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family contains a diverse range of structurally related DNA
#=GF CC repair proteins. The superfamily is called the HhH-GPD family
#=GF CC after its hallmark Helix-hairpin-helix and Gly/Pro rich loop
#=GF CC followed by a conserved aspartate [2]. This includes
#=GF CC endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine
#=GF CC glycosylase, both have a C terminal 4Fe-4S cluster. The family
#=GF CC also includes 8-oxoguanine DNA glycosylases such as
#=GF CC Swiss:P53397. The methyl-CPG binding protein MBD4 Swiss:Q9Z2D7
#=GF CC also contains a related domain [1] that is a thymine DNA
#=GF CC glycosylase. The family also includes DNA-3-methyladenine
#=GF CC glycosylase II EC:3.2.2.21 and other members of the AlkA family.
#=GF SQ 33494
#=GS A0A0C2HR21_9STAP/35-171 AC A0A0C2HR21.1
#=GS Q2U8L6_ASPOR/34-202 AC Q2U8L6.1
#=GS A0A2P8N8H7_9HYPH/47-189 AC A0A2P8N8H7.1
#=GS A0A8A3PCR7_9HELO/167-313 AC A0A8A3PCR7.1
#=GS A0A1L4BZW3_9LACT/55-188 AC A0A1L4BZW3.1
#=GS A0A512UCM8_9ASCO/166-319 AC A0A512UCM8.1
#=GS A0A1I3G748_9GAMM/43-179 AC A0A1I3G748.1
#=GS A0A2N4XHD1_9BACT/123-277 AC A0A2N4XHD1.1
#=GS A0A0S2FDY9_LYSAN/56-201 AC A0A0S2FDY9.1
#=GS A0A2K5ANS8_9ARCH/50-184 AC A0A2K5ANS8.1
#=GS A0A840QQG3_9BACI/35-171 AC A0A840QQG3.1
#=GS B7XIZ4_ENTBH/105-257 AC B7XIZ4.1
#=GS Q74D69_GEOSL/40-175 AC Q74D69.2
#=GS A0A1Y4RA73_9FIRM/35-171 AC A0A1Y4RA73.1
#=GS A0A6P5NA75_ARADU/175-319 AC A0A6P5NA75.1
#=GS F2K0P8_MARM1/34-169 AC F2K0P8.1
#=GS Q5SM31_THET8/46-181 AC Q5SM31.1
#=GS R4XCK0_TAPDE/165-311 AC R4XCK0.1
#=GS U3AK62_9VIBR/34-169 AC U3AK62.1
#=GS A0A1I1X012_9BACL/135-291 AC A0A1I1X012.1
#=GS A0A011NPH2_9PROT/79-214 AC A0A011NPH2.1
#=GS A0A5E4EMP5_PRUDU/98-225 AC A0A5E4EMP5.1
#=GS A0A1Y6B835_9HYPH/46-188 AC A0A1Y6B835.1
#=GS R7PH96_9CLOT/60-195 AC R7PH96.1
#=GS S5UYS5_STRC3/112-247 AC S5UYS5.1
#=GS A0A059FCY3_9PROT/46-188 AC A0A059FCY3.1
#=GS A0A225MGK2_9BURK/41-176 AC A0A225MGK2.1
#=GS A0A6M8BMW4_9CYAN/29-160 AC A0A6M8BMW4.1
#=GS L0PA36_PNEJ8/125-279 AC L0PA36.1
#=GS A0A2D0NDF3_FLAN2/47-192 AC A0A2D0NDF3.1
#=GS A0A7K8CZB4_9CORV/87-225 AC A0A7K8CZB4.1
#=GS A0A8A4ZFA3_9MICO/47-181 AC A0A8A4ZFA3.1
#=GS A0A086BFB3_9FLAO/35-170 AC A0A086BFB3.1
#=GS A0A3D9LDS3_9MICC/53-188 AC A0A3D9LDS3.1
#=GS A0A249DHJ8_LACRH/46-181 AC A0A249DHJ8.1
#=GS A0A371B801_9BRAD/48-190 AC A0A371B801.1
#=GS A0A2I0BFY3_9ASPA/32-180 AC A0A2I0BFY3.1
#=GS A0A5B2TL13_9PROT/46-188 AC A0A5B2TL13.1
#=GS A0A5M3Z1N8_ASPTE/192-332 AC A0A5M3Z1N8.1
#=GS A0A7W9MGI2_9ACTN/315-451 AC A0A7W9MGI2.1
#=GS G4CFU2_9NEIS/39-174 AC G4CFU2.1
#=GS A0A402CRJ9_9BACT/33-168 AC A0A402CRJ9.1
#=GS A0A1U7MMS7_9FIRM/36-171 AC A0A1U7MMS7.1
#=GS A0A154BN57_ANASB/49-190 AC A0A154BN57.1
#=GS A0A556MUI1_9SPHI/31-169 AC A0A556MUI1.1
#=GS C1MGT3_MICPC/91-239 AC C1MGT3.1
#=GS W1EHI5_KLEPN/37-172 AC W1EHI5.1
#=GS A0A1M4T350_9BACT/35-171 AC A0A1M4T350.1
#=GS A0A541BVY0_9PROT/31-174 AC A0A541BVY0.1
#=GS A0A1B7JQ13_9GAMM/35-170 AC A0A1B7JQ13.1
#=GS A0A4Q7MRT3_9BACT/139-294 AC A0A4Q7MRT3.1
#=GS A0A0A1VKS4_9BURK/37-172 AC A0A0A1VKS4.1
#=GS C8XAA6_NAKMY/26-159 AC C8XAA6.1
#=GS A0A3Q7GBD2_SOLLC/119-264 AC A0A3Q7GBD2.1
#=GS A0A7W0CAD7_9DELT/40-183 AC A0A7W0CAD7.1
#=GS A0A0F4QS26_9GAMM/34-169 AC A0A0F4QS26.1
#=GS A0A1H8JF14_9RHOB/51-188 AC A0A1H8JF14.1
#=GS A0A085L4S8_9FLAO/35-170 AC A0A085L4S8.1
#=GS A0A4P6XQN9_9ASCO/129-294 AC A0A4P6XQN9.1
#=GS A0A7K3XV71_9ACTN/44-185 AC A0A7K3XV71.1
#=GS R4YXT7_9ACTN/35-169 AC R4YXT7.1
#=GS A0A2A4G4Y6_9FLAO/34-168 AC A0A2A4G4Y6.1
#=GS A0A1S3U5Y8_VIGRR/168-319 AC A0A1S3U5Y8.1
#=GS A0A0V1DGI0_TRIBR/2585-2737 AC A0A0V1DGI0.1
#=GS A0A812LJL4_SYMPI/132-274 AC A0A812LJL4.1
#=GS A0A101N4X4_9ACTN/99-234 AC A0A101N4X4.1
#=GS A0A3S0TWW2_9BACI/45-180 AC A0A3S0TWW2.1
#=GS A0A8H5FBT4_9AGAR/159-336 AC A0A8H5FBT4.1
#=GS A0A6J0VVM1_ODOVR/433-542 AC A0A6J0VVM1.1
#=GS A0A1S8BIQ5_9PEZI/138-321 AC A0A1S8BIQ5.1
#=GS A0A4P7NWW9_9GAMM/36-171 AC A0A4P7NWW9.1
#=GS A0A6F8YI86_9ACTN/42-177 AC A0A6F8YI86.1
#=GS A0A5C1QTM5_9SPIO/27-162 AC A0A5C1QTM5.1
#=GS A0A8C9M7L8_PANTA/142-299 AC A0A8C9M7L8.1
#=GS U5T353_9GAMM/35-178 AC U5T353.1
#=GS A0A218Z938_9HELO/134-307 AC A0A218Z938.1
#=GS A0A7L0XCJ8_TYRSA/78-216 AC A0A7L0XCJ8.1
#=GS A0A1Z4IXX5_9CYAN/49-185 AC A0A1Z4IXX5.1
#=GS A0A0W8I2J0_9MICO/55-190 AC A0A0W8I2J0.1
#=GS A0A6M1L980_9ACTN/44-179 AC A0A6M1L980.1
#=GS A0A511XCU0_9PROT/46-190 AC A0A511XCU0.1
#=GS V2TLX0_9GAMM/35-168 AC V2TLX0.1
#=GS A0A399EEB4_9DEIN/37-169 AC A0A399EEB4.1
#=GS A0A0B4E126_9RHOB/51-188 AC A0A0B4E126.1
#=GS A0A2P4QYG8_RHIID/91-257 AC A0A2P4QYG8.1
#=GS A0A4R2L7E3_9FIRM/38-174 AC A0A4R2L7E3.1
#=GS A0A8H4TQS3_9HYPO/128-298 AC A0A8H4TQS3.1
#=GS A0A1Q5UHD8_9EURO/155-339 AC A0A1Q5UHD8.1
#=GS A0A090LJL0_STRRB/106-242 AC A0A090LJL0.1
#=GS A0A222MWX4_9PROT/32-167 AC A0A222MWX4.1
#=GS A0A2T4V0E0_VITXG/321-467 AC A0A2T4V0E0.1
#=GS S2EID9_9ARCH/3-137 AC S2EID9.1
#=GS A0A8H8C3Q2_9HELO/164-310 AC A0A8H8C3Q2.1
#=GS R6RGA8_9CLOT/108-260 AC R6RGA8.1
#=GS A0A6N6NRD4_9ACTN/42-180 AC A0A6N6NRD4.1
#=GS A0A087Y259_POEFO/149-304 AC A0A087Y259.1
#=GS A0A286DX10_9ACTN/100-235 AC A0A286DX10.1
#=GS F3NKI6_9ACTN/26-197 AC F3NKI6.1
#=GS A0A1T4MBR3_9ENTE/37-173 AC A0A1T4MBR3.1
#=GS A0A8H7WXJ1_9HELO/141-314 AC A0A8H7WXJ1.1
#=GS A0A328SFY9_9EURY/129-282 AC A0A328SFY9.1
#=GS A0A6N9YL58_9ACTN/44-179 AC A0A6N9YL58.1
#=GS W0F6A0_9BACT/47-189 AC W0F6A0.1
#=GS Q5P4X0_AROAE/40-175 AC Q5P4X0.1
#=GS A0A5B2WBD5_9PSEU/320-470 AC A0A5B2WBD5.1
#=GS A0A6M8SL40_9NEIS/34-169 AC A0A6M8SL40.1
#=GS A0A833RRX4_9HYME/205-343 AC A0A833RRX4.1
#=GS A0A557XYI8_9MYCO/24-190 AC A0A557XYI8.1
#=GS C4IE04_CLOBU/33-168 AC C4IE04.1
#=GS A0A2H5XD69_9BACT/42-178 AC A0A2H5XD69.1
#=GS B2HK71_MYCMM/60-195 AC B2HK71.1
#=GS A0A0G3CKF3_9GAMM/53-188 AC A0A0G3CKF3.1
#=GS A0A0Q9ZB22_9FLAO/35-170 AC A0A0Q9ZB22.1
#=GS A0A166S1Y2_9EURY/124-277 AC A0A166S1Y2.1
#=GS A0A518D6R7_9BACT/30-175 AC A0A518D6R7.1
#=GS A0A318LRH6_9PSEU/341-491 AC A0A318LRH6.1
#=GS A0A0B0H9F4_SOVGS/40-175 AC A0A0B0H9F4.1
#=GS A0A858QYK5_9GAMM/34-169 AC A0A858QYK5.1
#=GS A0A6L5ESW7_9PSEU/59-194 AC A0A6L5ESW7.1
#=GS A0A845B7W4_9PROT/51-197 AC A0A845B7W4.1
#=GS A0A1M6F710_9BACT/48-195 AC A0A1M6F710.1
#=GS A0A495IYJ0_9SPHI/47-188 AC A0A495IYJ0.1
#=GS A0A7G5ZSU2_9MICO/24-188 AC A0A7G5ZSU2.1
#=GS I7ZDB0_9GAMM/34-168 AC I7ZDB0.1
#=GS A0A6P2EPR1_9BURK/54-196 AC A0A6P2EPR1.1
#=GS A0A835ABJ5_9POAL/90-223 AC A0A835ABJ5.1
#=GS Q8XKS6_CLOPE/33-168 AC Q8XKS6.1
#=GS A0A7S9QEH5_9RHOB/38-173 AC A0A7S9QEH5.1
#=GS A0A251LJ82_MANES/180-357 AC A0A251LJ82.1
#=GS A0A514ZUB1_9BACT/42-177 AC A0A514ZUB1.1
#=GS A0A0Q8L6G8_9HYPH/57-193 AC A0A0Q8L6G8.1
#=GS A0A8C7A242_NOTPE/85-223 AC A0A8C7A242.1
#=GS A0A2T4JJD7_9RHOB/43-177 AC A0A2T4JJD7.1
#=GS A0A1H0UA24_9DELT/39-173 AC A0A1H0UA24.1
#=GS A0A1Z4VQ66_9GAMM/34-169 AC A0A1Z4VQ66.1
#=GS A0A1D3L2R4_9EURY/22-157 AC A0A1D3L2R4.1
#=GS A0A2B7ZUF5_9EURO/219-389 AC A0A2B7ZUF5.1
#=GS A0A8C3M1P0_CHRPC/103-241 AC A0A8C3M1P0.1
#=GS A0A414NER5_9ACTN/41-180 AC A0A414NER5.1
#=GS A0A1N7S0C7_9BURK/34-169 AC A0A1N7S0C7.1
#=GS A0A072N8J8_9DEIO/57-200 AC A0A072N8J8.1
#=GS J2M1R4_9BURK/34-169 AC J2M1R4.1
#=GS D4H3R3_DENA2/41-175 AC D4H3R3.1
#=GS A0A811RJH1_9POAL/169-313 AC A0A811RJH1.1
#=GS V6LCJ8_9EUKA/32-194 AC V6LCJ8.1
#=GS A0A1V6MLX7_9ACTN/349-499 AC A0A1V6MLX7.1
#=GS A0A7K3GPG7_9ACTN/33-168 AC A0A7K3GPG7.1
#=GS A0A7L5DXV6_9SPHI/47-189 AC A0A7L5DXV6.1
#=GS F5Y0W2_RAMTT/340-493 AC F5Y0W2.1
#=GS A0A1G5TNH9_9SPHN/34-169 AC A0A1G5TNH9.1
#=GS A0A1I7VGR0_LOALO/83-219 AC A0A1I7VGR0.1
#=GS A0A0A7LLV5_9BACT/39-186 AC A0A0A7LLV5.1
#=GS A0A8B7RSP6_HIPAR/134-272 AC A0A8B7RSP6.1
#=GS A0A1T4WHZ8_9BACT/35-171 AC A0A1T4WHZ8.1
#=GS A0A1M6CLR6_9CLOT/36-171 AC A0A1M6CLR6.1
#=GS A0A7H0G655_9SPHN/45-187 AC A0A7H0G655.1
#=GS A0A0A1TWY0_ENTIV/53-191 AC A0A0A1TWY0.1
#=GS A0A1C7GEI9_9FIRM/116-286 AC A0A1C7GEI9.1
#=GS A0A1H6E0S9_9ACTN/322-472 AC A0A1H6E0S9.1
#=GS A0A8J7JRA5_9CYAN/41-177 AC A0A8J7JRA5.1
#=GS V5AB49_9ARCH/48-188 AC V5AB49.1
#=GS A0A672I4N8_SALFA/92-228 AC A0A672I4N8.1
#=GS A0A1G7KXZ4_9SPHN/40-176 AC A0A1G7KXZ4.1
#=GS A0A1W1ZZZ9_9HYPH/54-187 AC A0A1W1ZZZ9.1
#=GS A0A8J5KH65_ZINOF/160-305 AC A0A8J5KH65.1
#=GS A0A3D9FFY4_9SPHN/43-189 AC A0A3D9FFY4.1
#=GS A0A839LH71_9BURK/331-482 AC A0A839LH71.1
#=GS A0A6M0QAF4_9BACI/43-178 AC A0A6M0QAF4.1
#=GS A0A0Q8K557_9HYPH/72-207 AC A0A0Q8K557.1
#=GS A0A6N0NQ41_9EURY/121-276 AC A0A6N0NQ41.1
#=GS A0A8J7ATT9_9CYAN/43-179 AC A0A8J7ATT9.1
#=GS N9USR9_9SPHN/45-187 AC N9USR9.1
#=GS A0A0F0KJJ2_9MICO/41-171 AC A0A0F0KJJ2.1
#=GS A0A7I8EM66_9CHLR/59-204 AC A0A7I8EM66.1
#=GS A0A1M7Z551_9HYPH/46-182 AC A0A1M7Z551.1
#=GS A0A7W9Z908_9GAMM/37-172 AC A0A7W9Z908.1
#=GS A0A517XP13_9BACT/41-176 AC A0A517XP13.1
#=GS A0A1F5LBB4_9EURO/173-320 AC A0A1F5LBB4.1
#=GS J3D7P8_9BURK/334-487 AC J3D7P8.1
#=GS D5BYA9_NITHN/35-170 AC D5BYA9.1
#=GS B5JYK1_9GAMM/35-170 AC B5JYK1.1
#=GS A0A2A2TGA8_9CYAN/50-192 AC A0A2A2TGA8.1
#=GS A0A7W9BPV0_9SPHN/39-174 AC A0A7W9BPV0.1
#=GS A0A0B7H215_9FLAO/34-168 AC A0A0B7H215.1
#=GS A0A0M8N7J1_9HYPO/116-255 AC A0A0M8N7J1.1
#=GS A0A3M2T4A2_9EURO/152-318 AC A0A3M2T4A2.1
#=GS A0A7K2JTJ5_9ACTN/338-488 AC A0A7K2JTJ5.1
#=GS A0A1E4V3J7_9PSED/128-278 AC A0A1E4V3J7.1
#=GS A0A1L9P0W9_9RHOB/43-179 AC A0A1L9P0W9.1
#=GS B1LXG3_METRJ/65-200 AC B1LXG3.1
#=GS A0A3D8VCE6_9GAMM/38-173 AC A0A3D8VCE6.1
#=GS A0A124I5E3_9ACTN/324-474 AC A0A124I5E3.1
#=GS A0A1Z9Z374_9GAMM/36-172 AC A0A1Z9Z374.1
#=GS A0A0U3MCV2_9BURK/34-169 AC A0A0U3MCV2.1
#=GS A0A673J152_9TELE/36-170 AC A0A673J152.1
#=GS A0A1U7IY71_9CYAN/37-179 AC A0A1U7IY71.1
#=GS A0A2W1JXI5_9CYAN/39-175 AC A0A2W1JXI5.1
#=GS A0A0Q5UTX2_9FLAO/35-170 AC A0A0Q5UTX2.1
#=GS M7PEH8_PNEMU/64-194 AC M7PEH8.1
#=GS A5K1Y6_PLAVS/231-367 AC A5K1Y6.1
#=GS D0NG48_PHYIT/81-222 AC D0NG48.1
#=GS A0A6H9YX51_9ACTN/26-190 AC A0A6H9YX51.1
#=GS A0A165ZDG2_9EURY/98-237 AC A0A165ZDG2.1
#=GS F3LG82_9GAMM/35-170 AC F3LG82.1
#=GS A0A4R4X8P1_9ACTN/58-193 AC A0A4R4X8P1.1
#=GS A0A6I4IAM9_9SPHI/35-171 AC A0A6I4IAM9.1
#=GS V8CBF3_9HELI/40-182 AC V8CBF3.1
#=GS A0A179D6E4_9BACT/35-171 AC A0A179D6E4.1
#=GS L7LPK2_9ACTN/44-179 AC L7LPK2.1
#=GS A0A8J0T3V5_XENTR/183-332 AC A0A8J0T3V5.1
#=GS A0A834TW38_9FABA/175-320 AC A0A834TW38.1
#=GS A0A0B7MKB6_9FIRM/48-183 AC A0A0B7MKB6.1
#=GS A0A8K0VFH7_9RHOB/38-173 AC A0A8K0VFH7.1
#=GS E9T4P6_RHOHA/26-193 AC E9T4P6.1
#=GS A0A164ID63_9NOCA/26-189 AC A0A164ID63.1
#=GS A0A5D4GXW6_9HYPH/50-186 AC A0A5D4GXW6.1
#=GS L7L522_9ACTN/25-169 AC L7L522.1
#=GS A0A842IQ61_9FLAO/35-170 AC A0A842IQ61.1
#=GS A0A1G5LKU3_9ACTN/74-209 AC A0A1G5LKU3.1
#=GS A0A1G5LC59_9HYPH/70-205 AC A0A1G5LC59.1
#=GS A0A5N3P433_9HYPH/44-176 AC A0A5N3P433.1
#=GS D1C2P2_SPHTD/50-195 AC D1C2P2.1
#=GS A0A0M2UYK1_9BACT/2-66 AC A0A0M2UYK1.1
#=GS A0A1Y4LG60_9FIRM/35-173 AC A0A1Y4LG60.1
#=GS S8CLP0_9LAMI/30-201 AC S8CLP0.1
#=GS A0A1Y6KXV2_9GAMM/34-169 AC A0A1Y6KXV2.1
#=GS A0A0Q8XFM3_9SPHN/45-187 AC A0A0Q8XFM3.1
#=GS A0A7C9IEW6_9RHOB/50-187 AC A0A7C9IEW6.1
#=GS A0A453SJT4_AEGTS/95-223 AC A0A453SJT4.1
#=GS A0A396SG78_9BACI/35-171 AC A0A396SG78.1
#=GS A0A368UTZ5_9BACT/35-171 AC A0A368UTZ5.1
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