#=GF ID IBR
#=GF AC PF01485.25
#=GF DE IBR domain, a half RING-finger domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Mistry J;0000-0003-2479-5322
#=GF SE [1]
#=GF GA 24.30 24.30;
#=GF TC 24.30 24.30;
#=GF NC 24.20 24.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0229
#=GF RC Discovery of IBR domain.
#=GF RN [1]
#=GF RM 10366851
#=GF RT A novel transactivation domain in parkin.
#=GF RA Morett E, Bork P;
#=GF RL Trends Biochem Sci 1999;24:229-231.
#=GF RN [2]
#=GF RM 10422847
#=GF RT TRIADs: a new class of proteins with a novel cysteine-rich
#=GF RT signature.
#=GF RA van der Reijden BA, Erpelinck-Verschueren CA, Lowenberg B,
#=GF RA Jansen JH;
#=GF RL Protein Sci 1999;8:1557-1561.
#=GF RN [3]
#=GF RM 15152079
#=GF RT Parkin and relatives: the RBR family of ubiquitin ligases.
#=GF RA Marin I, Lucas JI, Gradilla AC, Ferrus A;
#=GF RL Physiol Genomics 2004;17:253-263.
#=GF RN [4]
#=GF RM 12446796
#=GF RT Comparative genomics of the RBR family, including the
#=GF RT Parkinson's disease-related gene parkin and the genes of the
#=GF RT ariadne subfamily.
#=GF RA Marin I, Ferrus A;
#=GF RL Mol Biol Evol 2002;19:2039-2050.
#=GF RN [5]
#=GF RM 15236971
#=GF RT Structure of the C-terminal RING finger from a
#=GF RT RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain
#=GF RT distinct from a RING.
#=GF RA Capili AD, Edghill EL, Wu K, Borden KL;
#=GF RL J Mol Biol. 2004;340:1117-1129.
#=GF DR INTERPRO; IPR002867;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The IBR (In Between Ring fingers) domain is often found to occur
#=GF CC between pairs of ring fingers (Pfam:PF00097). This domain has
#=GF CC also been called the C6HC domain and DRIL (for double RING
#=GF CC finger linked) domain [2]. Proteins that contain two Ring
#=GF CC fingers and an IBR domain (these proteins are also termed RBR
#=GF CC family proteins) are thought to exist in all eukaryotic
#=GF CC organisms. RBR family members play roles in protein quality
#=GF CC control and can indirectly regulate transcription [3]. Evidence
#=GF CC suggests that RBR proteins are often parts of cullin-containing
#=GF CC ubiquitin ligase complexes. The ubiquitin ligase Parkin is an
#=GF CC RBR family protein whose mutations are involved in forms of
#=GF CC familial Parkinson's disease [3][4].
#=GF SQ 39217
#=GS A0A162Z2F5_DIDRA/191-257 AC A0A162Z2F5.1
#=GS A0A669DKY2_ORENI/173-238 AC A0A669DKY2.1
#=GS A0A835S1X3_VANPL/238-298 AC A0A835S1X3.1
#=GS A0A7J7CFJ1_TRIWF/282-339 AC A0A7J7CFJ1.1
#=GS A0A091NBV1_APAVI/35-103 AC A0A091NBV1.1
#=GS A0A835WWC9_9CHLO/322-388 AC A0A835WWC9.1
#=GS F0Y440_AURAN/286-346 AC F0Y440.1
#=GS A0A7L2FT64_QUIME/268-328 AC A0A7L2FT64.1
#=GS A0A7K7E1Y5_9SYLV/169-222 AC A0A7K7E1Y5.1
#=GS A0A1S3FWV2_DIPOR/777-839 AC A0A1S3FWV2.1
#=GS A0A7K6FTY4_9CORV/155-213 AC A0A7K6FTY4.1
#=GS A0A167JI96_CALVF/258-322 AC A0A167JI96.1
#=GS A0A4U0V7A8_9PEZI/677-735 AC A0A4U0V7A8.1
#=GS A0A1B6PMY2_SORBI/265-323 AC A0A1B6PMY2.1
#=GS A0A850WCE2_FREMA/109-170 AC A0A850WCE2.1
#=GS A0A091E9G5_CORBR/47-110 AC A0A091E9G5.1
#=GS A0A5F8GSV4_MONDO/2126-2189 AC A0A5F8GSV4.1
#=GS A0A0Q3USK0_AMAAE/53-113 AC A0A0Q3USK0.1
#=GS A0A0A1T704_9HYPO/287-392 AC A0A0A1T704.1
#=GS A0A8D2NJ19_ZONAL/169-222 AC A0A8D2NJ19.1
#=GS A0A672N716_SINGR/1907-1971 AC A0A672N716.1
#=GS A0A8C7CVH4_ONCKI/91-156 AC A0A8C7CVH4.1
#=GS A0A7K6VL30_9PASS/153-214 AC A0A7K6VL30.1
#=GS A0A8C9BMK8_PHOSS/502-560 AC A0A8C9BMK8.1
#=GS A0A1L7XGN8_9HELO/206-273 AC A0A1L7XGN8.1
#=GS N1PK48_DOTSN/240-299 AC N1PK48.1
#=GS A0A4W5MGQ6_9TELE/178-231 AC A0A4W5MGQ6.1
#=GS A0A2X0SAK3_WHEAT/301-358 AC A0A2X0SAK3.1
#=GS A0A8C1C377_CYPCA/181-246 AC A0A8C1C377.1
#=GS A0A7K8W7P3_9FURN/101-166 AC A0A7K8W7P3.1
#=GS C1GML6_PARBD/224-286 AC C1GML6.2
#=GS A0A7J9AHG2_9ROSI/203-264 AC A0A7J9AHG2.1
#=GS A0A8C3XKY4_CHESE/454-512 AC A0A8C3XKY4.1
#=GS A0A812NUG5_9DINO/10-70 AC A0A812NUG5.1
#=GS A0A8C6U6T8_9GOBI/136-193 AC A0A8C6U6T8.1
#=GS A0A443R0B6_9ACAR/210-275 AC A0A443R0B6.1
#=GS A0A4S4F011_CAMSI/337-394 AC A0A4S4F011.1
#=GS A0A7N4PHU1_SARHA/403-479 AC A0A7N4PHU1.1
#=GS N1RN20_FUSC4/479-544 AC N1RN20.1
#=GS A0A452EKL8_CAPHI/2143-2206 AC A0A452EKL8.1
#=GS A0A8C1APS3_CYPCA/211-270 AC A0A8C1APS3.1
#=GS A0A6J1AD51_9ROSI/206-268 AC A0A6J1AD51.1
#=GS A0A8C6HRI0_MUSSI/279-339 AC A0A8C6HRI0.1
#=GS A0A1L9RZE1_ASPWE/372-434 AC A0A1L9RZE1.1
#=GS A0A166N9R0_9PEZI/232-295 AC A0A166N9R0.1
#=GS B0WRV1_CULQU/125-172 AC B0WRV1.1
#=GS A0A7L1VLR0_SITEU/277-337 AC A0A7L1VLR0.1
#=GS A0A8C9JCL1_PANTA/211-272 AC A0A8C9JCL1.1
#=GS A0A2H5SVU5_RHIID/86-146 AC A0A2H5SVU5.1
#=GS K5WAP1_PHACS/282-337 AC K5WAP1.1
#=GS A0A1Q3BUE8_CEPFO/192-254 AC A0A1Q3BUE8.1
#=GS C4JGQ0_UNCRE/105-161 AC C4JGQ0.1
#=GS A0A8C5DPY0_9TELE/502-560 AC A0A8C5DPY0.1
#=GS A0A2I0UF54_LIMLA/257-314 AC A0A2I0UF54.1
#=GS A0A1S4A8K8_TOBAC/511-570 AC A0A1S4A8K8.1
#=GS A0A667WNK9_9TELE/284-344 AC A0A667WNK9.1
#=GS A0A0L0UY87_9BASI/238-305 AC A0A0L0UY87.1
#=GS A0A315VVL4_GAMAF/275-334 AC A0A315VVL4.1
#=GS A0A0A0A371_CHAVO/131-192 AC A0A0A0A371.1
#=GS A0A420Y9V9_9PEZI/679-739 AC A0A420Y9V9.1
#=GS A0A3Q3SFW5_9TELE/284-344 AC A0A3Q3SFW5.1
#=GS A0A0T6BHD1_9SCAR/269-333 AC A0A0T6BHD1.1
#=GS A0A6A1VR50_9ROSI/134-192 AC A0A6A1VR50.1
#=GS A0A6V7TH42_9BILA/266-330 AC A0A6V7TH42.1
#=GS A0A2G2Y5T5_CAPAN/28-90 AC A0A2G2Y5T5.1
#=GS Q5BE87_EMENI/509-565 AC Q5BE87.1
#=GS A0A6J3CS29_AYTFU/2089-2152 AC A0A6J3CS29.1
#=GS A0A151WNB4_9HYME/209-270 AC A0A151WNB4.1
#=GS A0A0N1IHQ5_PAPMA/59-120 AC A0A0N1IHQ5.1
#=GS A0A1X7UFU7_AMPQE/375-439 AC A0A1X7UFU7.1
#=GS G1NU39_MYOLU/62-117 AC G1NU39.1
#=GS A0A5J4NGJ1_9TREM/259-322 AC A0A5J4NGJ1.1
#=GS A0A7L2V987_9AVES/69-134 AC A0A7L2V987.1
#=GS A0A669CBV0_ORENI/188-253 AC A0A669CBV0.1
#=GS A0A7L1ZL35_LEILU/192-249 AC A0A7L1ZL35.1
#=GS A0A667X6U9_9TELE/303-350 AC A0A667X6U9.1
#=GS A0A7L0U5I0_CHOAC/340-416 AC A0A7L0U5I0.1
#=GS A0A5F8HJ37_MONDO/1460-1523 AC A0A5F8HJ37.1
#=GS F0Y440_AURAN/215-278 AC F0Y440.1
#=GS A0A067DR31_CITSI/213-275 AC A0A067DR31.1
#=GS A0A2G3B0M5_CAPCH/1276-1342 AC A0A2G3B0M5.1
#=GS A0A5N3XPX0_MUNRE/777-839 AC A0A5N3XPX0.1
#=GS M4B6J6_HYAAE/226-285 AC M4B6J6.1
#=GS G4UXD2_NEUT9/209-276 AC G4UXD2.1
#=GS A0A8H4K1Q2_9HYPO/347-409 AC A0A8H4K1Q2.1
#=GS A0A5C3NX62_9APHY/282-343 AC A0A5C3NX62.1
#=GS A0A5E4E441_PRUDU/260-323 AC A0A5E4E441.1
#=GS A0A453CWC3_AEGTS/304-361 AC A0A453CWC3.1
#=GS A0A087GRK6_ARAAL/235-296 AC A0A087GRK6.1
#=GS A0A1S3LYZ8_SALSA/830-887 AC A0A1S3LYZ8.1
#=GS A0A7L0ERZ7_TROML/277-337 AC A0A7L0ERZ7.1
#=GS A0A3Q1H7V2_ANATE/444-502 AC A0A3Q1H7V2.1
#=GS A0A1E3QVR9_9ASCO/208-269 AC A0A1E3QVR9.1
#=GS A0A6P6IB39_PUMCO/502-560 AC A0A6P6IB39.1
#=GS A0A1Y2I6J2_PYCCO/243-315 AC A0A1Y2I6J2.1
#=GS A0A8H7SP27_9FUNG/200-267 AC A0A8H7SP27.1
#=GS A0A835MTH7_9ROSI/208-270 AC A0A835MTH7.1
#=GS A0A2A4JJ21_HELVI/1936-1998 AC A0A2A4JJ21.1
#=GS A0A087R7P6_APTFO/47-110 AC A0A087R7P6.1
#=GS C5WRT5_SORBI/278-334 AC C5WRT5.1
#=GS C7YQ22_FUSV7/252-317 AC C7YQ22.1
#=GS A0A1U8A7U9_NELNU/106-166 AC A0A1U8A7U9.1
#=GS A0A5N5HQ64_9ROSA/279-340 AC A0A5N5HQ64.1
#=GS A7F5S9_SCLS1/371-437 AC A7F5S9.1
#=GS A0A1U8D420_ALLSI/101-166 AC A0A1U8D420.1
#=GS A0A7K5TWX2_CEPOR/183-248 AC A0A7K5TWX2.1
#=GS A0A6P3GZC4_BISBI/394-453 AC A0A6P3GZC4.1
#=GS A0A8D2J9X1_VARKO/178-230 AC A0A8D2J9X1.1
#=GS A0A194XW52_9HELO/286-340 AC A0A194XW52.1
#=GS A0A0E0MPX0_ORYPU/349-405 AC A0A0E0MPX0.1
#=GS A0A7K5JRL9_9TYRA/289-350 AC A0A7K5JRL9.1
#=GS A0A8B9F3H1_9PSIT/205-259 AC A0A8B9F3H1.1
#=GS A0A5J5F9X9_9PEZI/203-270 AC A0A5J5F9X9.1
#=GS A0A453CAM4_AEGTS/194-256 AC A0A453CAM4.1
#=GS A0A0E0F1B3_9ORYZ/345-418 AC A0A0E0F1B3.1
#=GS A0A8J5WQK7_ZIZPA/202-245 AC A0A8J5WQK7.1
#=GS A0A6J2XFP7_SITOR/200-261 AC A0A6J2XFP7.1
#=GS A0A5A7PEJ3_STRAF/211-273 AC A0A5A7PEJ3.1
#=GS A0A671PN34_9TELE/481-538 AC A0A671PN34.1
#=GS A0A7K5SHQ9_9FRIN/91-156 AC A0A7K5SHQ9.1
#=GS A0A851Q6Z7_ANHAN/157-213 AC A0A851Q6Z7.1
#=GS A0A672YTC7_9TELE/409-483 AC A0A672YTC7.1
#=GS A0A835JS20_9ROSI/208-270 AC A0A835JS20.1
#=GS A0A2J7Q522_9NEOP/592-657 AC A0A2J7Q522.1
#=GS A0A8C5BVL9_GADMO/215-277 AC A0A8C5BVL9.1
#=GS A0A7N6FDJ9_ANATE/2282-2345 AC A0A7N6FDJ9.1
#=GS A0A178EBZ0_9PLEO/73-134 AC A0A178EBZ0.1
#=GS A0A665U0S1_ECHNA/397-471 AC A0A665U0S1.1
#=GS A0A165G7V4_EXIGL/156-209 AC A0A165G7V4.1
#=GS A0A5J4ZYB2_9ASTE/460-518 AC A0A5J4ZYB2.1
#=GS A0A1U8D420_ALLSI/179-227 AC A0A1U8D420.1
#=GS A0A8D2LPC1_VARKO/502-560 AC A0A8D2LPC1.1
#=GS A0A067LFF0_JATCU/289-350 AC A0A067LFF0.1
#=GS A0A087VIS8_BALRE/101-166 AC A0A087VIS8.1
#=GS A0A7K5LVQ4_CARCD/404-480 AC A0A7K5LVQ4.1
#=GS F9G609_FUSOF/282-347 AC F9G609.1
#=GS A0A2I2UT62_FELCA/139-204 AC A0A2I2UT62.2
#=GS G3WIH3_SARHA/289-350 AC G3WIH3.2
#=GS A0A4Z1JLW7_9HELO/676-739 AC A0A4Z1JLW7.1
#=GS A0A225WZU3_9STRA/303-362 AC A0A225WZU3.1
#=GS A0A803LDL3_CHEQI/178-240 AC A0A803LDL3.1
#=GS A0A1U8BAU7_NELNU/520-580 AC A0A1U8BAU7.1
#=GS G0RZY2_CHATD/385-441 AC G0RZY2.1
#=GS A0A177BV39_9PLEO/11-87 AC A0A177BV39.1
#=GS A0A851M5G9_9DEND/289-350 AC A0A851M5G9.1
#=GS A0A6A3B747_HIBSY/320-378 AC A0A6A3B747.1
#=GS A0A6P5RGP4_PRUAV/255-312 AC A0A6P5RGP4.1
#=GS A0A3N4IAR9_ASCIM/314-369 AC A0A3N4IAR9.1
#=GS A0A6V8QUI6_9HYPO/302-365 AC A0A6V8QUI6.1
#=GS A0A3P6PYQ5_TAEAS/302-382 AC A0A3P6PYQ5.1
#=GS A0A8C4FX54_9TELE/272-332 AC A0A8C4FX54.1
#=GS A0A0D9YWS4_9ORYZ/1466-1526 AC A0A0D9YWS4.1
#=GS A0A168HB12_CORDF/291-395 AC A0A168HB12.1
#=GS A0A0C2S619_AMAMK/240-336 AC A0A0C2S619.1
#=GS B4L277_DROMO/274-338 AC B4L277.1
#=GS G5BNL7_HETGA/2161-2224 AC G5BNL7.1
#=GS E9DEG8_COCPS/330-385 AC E9DEG8.1
#=GS A0A453KWZ4_AEGTS/82-150 AC A0A453KWZ4.1
#=GS G0MMG7_CAEBE/225-282 AC G0MMG7.1
#=GS A0A812VRK4_SYMPI/183-244 AC A0A812VRK4.1
#=GS A0A0L0TBG1_ALLM3/291-352 AC A0A0L0TBG1.1
#=GS A0A1D2V934_9ASCO/263-352 AC A0A1D2V934.1
#=GS A0A815R0R9_9BILA/295-353 AC A0A815R0R9.1
#=GS A0A1Y1XN59_9FUNG/296-358 AC A0A1Y1XN59.1
#=GS A0A517L074_9PEZI/253-311 AC A0A517L074.1
#=GS A0A6P6PE86_CARAU/130-195 AC A0A6P6PE86.1
#=GS A0A4S8JTJ6_MUSBA/455-519 AC A0A4S8JTJ6.1
#=GS A0A7J9M2X1_GOSSC/199-261 AC A0A7J9M2X1.1
#=GS A0A6J3LBV3_9HYME/268-329 AC A0A6J3LBV3.1
#=GS A0A7J7RMD8_PIPKU/284-348 AC A0A7J7RMD8.1
#=GS A0A2D3ULC4_9PEZI/306-373 AC A0A2D3ULC4.1
#=GS J3PI84_GAET3/842-895 AC J3PI84.1
#=GS A0A7J8V336_9ROSI/521-581 AC A0A7J8V336.1
#=GS A0A837A8B3_9ROSI/126-211 AC A0A837A8B3.1
#=GS A0A6G1DJL0_9ORYZ/208-270 AC A0A6G1DJL0.1
#=GS A0A4P9VZ35_9FUNG/56-123 AC A0A4P9VZ35.1
#=GS A0A2I4FF35_JUGRE/167-231 AC A0A2I4FF35.1
#=GS A0A8H5LU12_9AGAR/977-1038 AC A0A8H5LU12.1
#=GS A0A7K8WPC8_9FURN/404-480 AC A0A7K8WPC8.1
#=GS A0A423WNJ9_9PEZI/466-521 AC A0A423WNJ9.1
#=GS A0A671XBI9_SPAAU/195-260 AC A0A671XBI9.1
#=GS A0A4S4DU15_CAMSI/270-331 AC A0A4S4DU15.1
#=GS A0A7K8QCY8_9PASS/183-248 AC A0A7K8QCY8.1
#=GS A0A7J8K6S3_ROUAE/2189-2252 AC A0A7J8K6S3.1
#=GS A0A364N0G1_9PLEO/478-533 AC A0A364N0G1.1
#=GS A0A2U1N3A0_ARTAN/201-263 AC A0A2U1N3A0.1
#=GS A0A1L9S5E3_9EURO/298-353 AC A0A1L9S5E3.1
#=GS A0A2C9W3B1_MANES/229-288 AC A0A2C9W3B1.1
#=GS A0A0L0DPK4_THETB/2792-2855 AC A0A0L0DPK4.1
#=GS A4RSK7_OSTLU/395-449 AC A4RSK7.1
#=GS A0A8H4ULY0_9HYPO/659-717 AC A0A8H4ULY0.1
#=GS A0A6J2V5K7_CHACN/413-473 AC A0A6J2V5K7.1
#=GS A0A8B8Z095_BALMU/326-394 AC A0A8B8Z095.1
#=GS A0A8H6JDI1_9PEZI/752-816 AC A0A8H6JDI1.1
#=GS A0A445E2T2_ARAHY/153-219 AC A0A445E2T2.1
#=GS A0A2I1G9R0_9GLOM/206-273 AC A0A2I1G9R0.1
#=GS A0A0E0ENG4_9ORYZ/212-273 AC A0A0E0ENG4.1
#=GS A0A8C3UJM9_CATUS/116-172 AC A0A8C3UJM9.1
#=GS A0A0D3H6X6_9ORYZ/179-243 AC A0A0D3H6X6.1
#=GS A0A3L6PL61_PANMI/184-252 AC A0A3L6PL61.1
#=GS A0A8X8ZLN2_SALSN/229-291 AC A0A8X8ZLN2.1
#=GS A0A815V866_9BILA/245-305 AC A0A815V866.1
#=GS A0A5J5CJ00_9PERO/713-775 AC A0A5J5CJ00.1
#=GS A9V3B3_MONBE/158-209 AC A9V3B3.1
#=GS A0A6J2GWJ2_9PASS/366-428 AC A0A6J2GWJ2.1
#=GS A0A074S1A9_9AGAM/206-268 AC A0A074S1A9.1
#=GS W7N058_GIBM7/664-729 AC W7N058.1
#=GS A0A2C9W3B1_MANES/154-217 AC A0A2C9W3B1.1
#=GS A0A093T2D5_9PASS/91-156 AC A0A093T2D5.1
#=GS A0A1U8EX05_CAPAN/1276-1342 AC A0A1U8EX05.1
#=GS A0A5A7PQ08_STRAF/373-433 AC A0A5A7PQ08.1
#=GS A0A6J5XQ84_PRUAR/133-203 AC A0A6J5XQ84.1
#=GS A0A8B9CMB6_9AVES/205-265 AC A0A8B9CMB6.1
#=GS A0A2J6TF72_9HELO/202-262 AC A0A2J6TF72.1
#=GS W8BK16_CERCA/314-375 AC W8BK16.1
#=GS A0A453HD73_AEGTS/133-196 AC A0A453HD73.1
#=GS A0A3Q2WD32_HAPBU/611-673 AC A0A3Q2WD32.1
#=GS A0A8C5XUS9_MICMU/199-259 AC A0A8C5XUS9.1
#=GS A0A2C9V1P8_MANES/212-274 AC A0A2C9V1P8.1
#=GS A0A8B6EYY0_MYTGA/225-287 AC A0A8B6EYY0.1
#=GS A0A509AG38_PLABA/259-333 AC A0A509AG38.1
#=GS A0A1U7RUV8_ALLSI/77-133 AC A0A1U7RUV8.1
#=GS A0A7J7HHU3_CAMSI/104-166 AC A0A7J7HHU3.1
#=GS R1GFH7_BOTPV/283-383 AC R1GFH7.1
#=GS A0A369JH27_HYPMA/882-943 AC A0A369JH27.1
#=GS A0A833S056_9HYME/176-241 AC A0A833S056.1
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