#=GF ID Imm64
#=GF AC PF15600.11
#=GF DE Immunity protein 64
#=GF PI Imm39; Imm39_;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 25.50 30.00;
#=GF NC 23.50 23.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 81514348 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028951;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted immunity protein with an alpha+beta fold and a
#=GF CC conserved DxEA motif and arginine residue. Proteins containing
#=GF CC this domain are present in bacterial polymorphic toxin systems
#=GF CC as an immediate gene neighbour of the toxin gene, which usually
#=GF CC contains toxin domains of the Tox-ColD family [1].
#=GF SQ 21
#=GS A0A8U0H0F2_9FIRM/10-184 AC A0A8U0H0F2.1
#=GS A0A941AM94_9BACI/12-194 AC A0A941AM94.1
#=GS A0A0C1R5N6_9CLOT/1-200 AC A0A0C1R5N6.1
#=GS A0A6G7X0S7_9FIRM/8-182 AC A0A6G7X0S7.1
#=GS A0A7V7UBK9_9FIRM/1-195 AC A0A7V7UBK9.1
#=GS A0A371J2H1_9FIRM/1-195 AC A0A371J2H1.1
#=GS A0A6G7Y151_9FIRM/3-184 AC A0A6G7Y151.1
#=GS A0A7R7EHQ4_9FIRM/1-194 AC A0A7R7EHQ4.1
#=GS E7FY67_ERYRH/10-184 AC E7FY67.1
#=GS A0A1B8UJD8_9BACL/1-189 AC A0A1B8UJD8.1
#=GS A0A1B3XNH5_9BACI/5-189 AC A0A1B3XNH5.1
#=GS A0A6B3VX78_9BACI/1-190 AC A0A6B3VX78.1
#=GS A0A1G7VJE4_9BACL/1-189 AC A0A1G7VJE4.1
#=GS Q8TP73_METAC/4-210 AC Q8TP73.1
#=GS A0A927IUN9_9BACI/3-188 AC A0A927IUN9.1
#=GS B8I7J1_RUMCH/1-195 AC B8I7J1.1
#=GS A0A7G9S0W5_9FIRM/46-186 AC A0A7G9S0W5.1
#=GS W9DTL0_METTI/1-207 AC W9DTL0.1
#=GS F5LRH0_9BACL/1-189 AC F5LRH0.1
#=GS A0A2N0ZBS5_9BACI/3-193 AC A0A2N0ZBS5.1
#=GS A0A6G7Z9B8_9FIRM/5-185 AC A0A6G7Z9B8.1
A0A8U0H0F2_9FIRM/10-184 ......................................................................................vleasdktigqien------------------------------------ILD-LVDSYK.TKMEITHPKDGDYHDWITETVDGNIY-TTIEKLAY.RTSYADIEFK.---IGN..KDVETRMSIT.NET.D..ALVVKFDIVEEHL.LPEKS..VE.HLEATTQLMTHIFEIIDRNVEYEYLFCDSEAEYLYSKQRLLE..VGHQPYALFKMN..DRNT-----VYAEWYLDGFTLR.......................
A0A941AM94_9BACI/12-194 ....................................................................................vfneqhslvdtigdmk---------------------------------------AFLQHKGcRLVSVKFSEDIDGENWVEIDIHDNKL-D---DSFL.DGYYMSVELS.GSIFDSmtDEIATTLRIE.KES.N..YHGYLFSINWGDL.FPDEN..NElEIRHTRQKIVGTLIELYQTISYSYAFVGHEIEIELDPEEFAR..TIADNHSYPV--..----------------------amvraeggldlyygstgidgfsk
A0A0C1R5N6_9CLOT/1-200 ....................................................................................................MGSSISIG-----------FVYGEFSIQAIENEIKRLVKYFVTTDG.SLKKMKVSKDIDGEEWLEYDSLINLKVDSIYTTLA.ENYYGQVEVN.SSLFGH..KNLTTTIRIE.KEE.DegYFGFLLDIDEEEL.IKTNL..AS.EINSVTEKIVDFITGFYSYSAYDYAFCDNEAEIQYSPRHFKK..IESSIYSISVIPtlDGNSNSLNIVRSNWNIDGLTSR.......................
A0A6G7X0S7_9FIRM/8-182 givlkndinitkelenffdfleiyvhqiqvnfpeegdyedweekilvdnyvqlidllafrgayasfdlefnhehfatrlslsnegddlvvhlalhhpfek----------------------------------------------.-----------------------------------.----------.------..----------.---.-..-------------.---RD..IQ.SLELLTQGIASFIDTIDTHVVHDYIFCDNEAEYLYKKERMLE..LGYNPYAILKLH..DR-----MLVQAAWYLDGFTER.......................
A0A7V7UBK9_9FIRM/1-195 ....................................................................................................MGSFISIG-----------IVYTDKNIIKMGDDLVDIIKYLSPFCN.KI-VVNYPDDDICENWEEKSFVGEEGFEKAFSILN.DKKFSTGKIY.CKIQ-N..KDYNVLVSIKgKND.L..FRGILFEIPEEELfLEKFS..SD.ILDIITDKIANSIIELWNNTEFNYAFCDSEADIEYSLCEVRA..SEKPIYSMLLLK..NEFNQPI-VRLGSWCIDGLTPR.......................
A0A371J2H1_9FIRM/1-195 ....................................................................................................MGSYINIG-----------IVYTDKNIIKMDDDFVIVIKYLSPFCN.KI-VVKYPKDDAFENWEEKSFEGEEGFVEAFSILN.EKNFSTGKIY.CKIQNK..Q-YNILVSIKgKND.L..FRGILFEIPEEELfLENSS..SD.NLSLTTNKIANSIIELWNNTEFNYAFCDSEADIEYSLCEVRE..SEKPIYSMLLLK..NEFNQPI-VRLGSWCIDGLTPR.......................
A0A6G7Y151_9FIRM/3-184 .........................................................................................tyiglgvvlkn--------------------------DESLANELENIMDLLENHAQ.EI-VVTYPKDGDLNDWQHEAIEGRLY--DVIDYLTyRTSYADMMLD.---LGG..RVVEARLSLT.NES.D..VAVMKLEIADKGM.FKDRT..LE.DLEAVTSILTDFIEAIDRSVTYSYIFCDNEAEFLYTKERLLE..VGYNPYAILKMH..DRTT-----AYAAWYVDGFTER.......................
A0A7R7EHQ4_9FIRM/1-194 ....................................................................................................MGSYISVG-----------FIYDKISIDNIKNKMKSLIDFIVSKKG.EIKRAKICKDIYGDEWIEYELNDNTQIDNMLVLLA.EHYFGQIEIE.TNLFDL..MNLDITVHVE.KEE.G..YFGFILDISESAF.Y-KDS..LN.MVNSYTDKFIDLMKKFYKCSAYNYAFCDNEAEIKYSPLAFRN..LNKRVYSLAILP..VHNN-NLRVIKSEWNIDGITNR.......................
E7FY67_ERYRH/10-184 ......................................................................................vleasdktigqien------------------------------------ILD-LVDSYK.TKMEITHPKDGDYHDWITETVDGNIY-TTIEKLAY.RTSYADIEFK.---IGN..KDVETRMSIT.NET.D..ALVVKFDIVEEHL.LPEKS..VE.HLEATTQLMTHIFEIIDRNVEYEYLFCDSEAEYLYSKQRLLE..VGHQPYALFKMN..DRNT-----VYAEWYLDGFTLR.......................
A0A1B8UJD8_9BACL/1-189 ..................................................................................mgasinvgliycneldvf------------------------------SKRLYSIMDFLVSSQG.EILSMKYALDEDALNWVETGTCRS-VDSNLINELL.QNYFAEISIN.TGSLFV..NSKNICISVE.KNEgH..HSGVIISFQESEI.IVDYS..IE.ELDSATDFMVDFIKQVYQIAPFDFAFCDHEAEIIYPLNGVE-..-----YSIMIYP..TSVASDILVEKSNWHLNGLTKR.......................
A0A1B3XNH5_9BACI/5-189 ...............................................................................................lslgi--------------------VYENSF-DK-SEELQSIIQYFLNLKS.DIVGIKISMDEDGENWLESERNGKNFILD-YTLLT.EKYFGEILIQlNDFWSL..NGLSLTLRIV.KEN.D..FFGYLLDFEMEQL.LNRYS..LD.LIN---ELIIDLVKDIYSVTKFNYAFCDHDSEIEYSPSQYKD..IVEA-YSILILP..R-AKNGFDVIKNNWQIDGITSR.......................
A0A6B3VX78_9BACI/1-190 ...................................................................................................m-GSNISLG-----------IVYASNQLANAENITRNVSNLFVSDDG.YIKSFKYSTDLQGTKWKEFSGINSELAKSMYSSLI.NSYYGSITIM.SNLFNE..KLKEMVISIE.VTN.E..YFGFLVDIKEELL.EGIN-..--.-LDELEENIINFFMKNYECLKFNYAFCDHEAEIEFSPDEIAH..MTDEVYSILLLQ..--VNNELVLEKSSWKIDGLTER.......................
A0A1G7VJE4_9BACL/1-189 ...................................................................................................m-GSTINIG-----------LVYNDS--KAIGKILEKLLGLVVENNG.HFQSVKFCEDYDGESWIELDYPNMD--TTFIDKMT.KSYFVQIQSC.LDLFQI..EQLKTDIRIE.KYD.E..FFGLLLLFNEDEI.LPNYS..IE.SLEKITNSIINFIVEVHPVLNFDYAFCDHEAEIEYSPKEFKP..---EKYSLSFLP..NLTNGVLGVRKSSWEINGLTER.......................
Q8TP73_METAC/4-210 ....................................................................................................MGSYISIGLTYGIVQRFANLVYDDATNNKIEKELKKLIEYFLDSDG.IIKNIKYSEDLEGEHWKEVNSPSPFFPRDCYKSFS.RGFYGEVAVH.ADILKR..RGVDLIMRLE.KQS.E..FFGFLLDIKEEDL.LETHS..KE.EIGYMTEELIDTMMSIYKYSKYDYTFCDQEAEFKYSLSSLKK..LKEDVYSIVIIP..DSDNNSFTVIKSDWNIDGLTGR.......................
A0A927IUN9_9BACI/3-188 ................................................................................qggyinigivfsneqeyvrv---------------------------------FESIVEFVVKKGS.HFSHVKYSKDIDGTIWIEQQIKNNVIEMECLS---.-GYYIGFTLS.GEFLNL..NFSKIGLVIT.KET.G..YFGFLLEINWSDV.----S..SD.NLITTQRNIENQLIDLYKALSYEYAFVGHEIEIEIHPADYEAfiVNNESYPVGIIG..R--DKCVDIYYGTSGIDGLT--vq.....................
B8I7J1_RUMCH/1-195 ....................................................................................................MGSYIGIG-----------FVYNGMSGERVEIELKNIVNFLISHNG.NINSIKFSKDEYGNVWIQDSLNNKCI-DDFYSSLC.NGYFGELHIT.CSILSV..QNLNVCIRIE.KAK.K..YFGLLLDISEEEL.IGVNS..SE.NINRITEEIIEFFNELYKASVFEYAICDNEAEIQYSPEEFQS..IGEAVYSIAALP..EKNKKSLKIIKNSWHIDGLTAR.......................
A0A7G9S0W5_9FIRM/46-186 ...............................................................ddwveepvqstddmnliveklayktsyadinlemgdy----------------------------------------------.-----------------------------------.----------.------..-NLETRLQLS.NEE.K..DFLVHFEIDQASL.IRDNS..RE.SLEKATSLIKSLIQSIDEAVDYSYIFCDQEAQYLYTKSRLIE..IAHNPYAILKMH..ERE-----IVQAPWYLDGFTLR.......................
W9DTL0_METTI/1-207 ....................................................................................................MGARISIGLTYGIG-NLKTLVYDDATVEKLQQELKNIIGYFLDSNG.TIKVAKYSENADGENWKEINLDSLFFSLENLKDFS.SGYYGEILLN.SEIIKG..KKLDYTIRTV.KET.N..FFGFLLDIEEADI.FKSTSypDE.EIDSITEKLITTMCRIYSHSKYDYAFCDLEAQFYYPLEIFKH..SDGYIYSVTIIP..NSDSN-LTVIKSDWHIDGHNAR.......................
F5LRH0_9BACL/1-189 ....................................................................................................MGSYINIG-----------LIYS--SSEATEAHLMKLIELLTENEG.RIENVKFCEDVDGERWIQYDFPHHDP--AIFEKLT.RSYYGHIYLF.ADLVPF..KGLNVEIEIE.KCE.G..YSGFLVSFRESEM.LPDYS..AD.SLETATETLVKLVAEIYPAVPFDYAFCDLEAQIEFSPQEFK-..--PERYSLSFWP..DISNGELKVTKSNCHINGLTER.......................
A0A2N0ZBS5_9BACI/3-193 .......................................................................................atmnvifvksdls----------------------------TLKNNFSSLLNYFLNNSI.GFSSLHISNDEEGFNGIDYNNPNQTFLENIMDKSP.DFYYLKLSFN.NFPFGN..LFIDGLLKIE.KHEnS..YYSFGFEFEEVDI.LSNYD..VD.SLESVEKNIINTIEKIGENINWDYAFANQEAEVQFSPEQFEK..ETNTQYAIEITN..--SESGLKISKSTWYVNGITER.......................
A0A6G7Z9B8_9FIRM/5-185 .................................................................figlgivienddnlmieventldllneyadnimlt----------------------------------------------.------YPHEGNTDDWRTDSFEGKLN--EMIEGLSyRTAYADMEL-.--ILGN..EVYEARLSMS.NEG.T..VTVLKFEISDRDV.FHDRT..FE.DLERVTQIFTEFIRTIDRNVHHSYIFCDNEADFLYKKERLIE..VGYNPYAIIKMG..DRD-----VAYAAWYLDGFTER.......................
#=GC seq_cons ................................................................................................................................t.tt.h.pllphhlspps.pl.slKascDh-ucsWh-.sh.sp.h..shhs.hs.csaauplplp.sphhs...pslphplpIp.Kps.p..ahGhlh-IsEp-l.l.spS..h-.pL-phTpplhshlpplapsspasYAFCDpEAElpYS.pchpc..hspp.YSlhhhs..spsst.h.lhpusWtlDGlTtR.......................
//
