#=GF ID IpaB_EvcA
#=GF AC PF03278.16
#=GF DE IpaB/EvcA family
#=GF AU Mifsud W;0000-0002-9805-6461
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_4003 (release 6.5)
#=GF GA 29.90 29.90;
#=GF TC 30.20 35.70;
#=GF NC 25.90 25.50;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 11207575
#=GF RT Bacterial signals and cell responses during Shigella entry into
#=GF RT epithelial cells.
#=GF RA Tran Van Nhieu G, Bourdet-Sicard R, Dumenil G, Blocker A,
#=GF RA Sansonetti PJ;
#=GF RL Cell Microbiol 2000;2:187-193.
#=GF RN [2]
#=GF RM 9784578
#=GF RT Translocated intimin receptors (Tir) of Shiga-toxigenic
#=GF RT Escherichia coli isolates belonging to serogroups O26, O111, and
#=GF RT O157 react with sera from patients with hemolytic-uremic
#=GF RT syndrome and exhibit marked sequence heterogeneity.
#=GF RA Paton AW, Manning PA, Woodrow MC, Paton JC;
#=GF RL Infect Immun 1998;66:5580-5586.
#=GF DR INTERPRO; IPR004959;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family includes IpaB, which is an invasion plasmid antigen
#=GF CC from Shigella [1], as well as EvcA from E. coli Swiss:Q9ZNF1.
#=GF CC Members of this family seem to be involved in pathogenicity of
#=GF CC some enterobacteria. However the exact function of this
#=GF CC component is not clear.
#=GF SQ 16
#=GS C0B3H5_9GAMM/1-126 AC C0B3H5.1
#=GS A0A653FS40_9CAUD/1-129 AC A0A653FS40.1
#=GS D2TM85_CITRI/35-179 AC D2TM85.1
#=GS Q8X4W3_ECO57/39-185 AC Q8X4W3.1
#=GS Q7DB76_ECO57/44-192 AC Q7DB76.1
#=GS Q8X4Q6_ECO57/39-186 AC Q8X4Q6.1
#=GS A0A2U8I374_9GAMM/171-318 AC A0A2U8I374.1
#=GS Q327H0_SHIDS/34-177 AC Q327H0.1
#=GS IPGB_SHIFL/44-197 AC P33548.1
#=GS Q326S7_SHIDS/44-197 AC Q326S7.1
#=GS D2TKE9_CITRI/43-192 AC D2TKE9.1
#=GS A0A6L2ZQN6_9ENTR/180-344 AC A0A6L2ZQN6.1
#=GS H3RGA5_PANSE/178-329 AC H3RGA5.1
#=GS D2TI21_CITRI/35-184 AC D2TI21.1
#=GS D2TI15_CITRI/33-185 AC D2TI15.1
#=GS Q9AJW7_SHIFL/31-174 AC Q9AJW7.1
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LYQ A; 31-174;
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LW8 G; 31-174;
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LW8 H; 31-174;
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LYQ B; 31-174;
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LW8 F; 31-174;
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LXR F; 31-174;
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LWN F; 31-174;
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LWN G; 31-174;
#=GS Q9AJW7_SHIFL/31-174 DR PDB; 3LW8 E; 31-174;
C0B3H5_9GAMM/1-126 ..........mkk-------------------------IDK.DISGWWKDEKKILPSSIINRTIDNLY...KRDKVIINKETK......QI.LFFLISKK...F.......-NLNLDENAAQSTmIQHL--QDIPE---VVKAIDEL..G.--.--...-------------------------------------ssensylkyenycliteyiynflsenkvdfskikeavkei
A0A653FS40_9CAUD/1-129 .........mvgk------------------------QCTK.NIDGWIKDERVVYPSRVINQEIDNYC...FQKNVKISTEER......KR.VFSLVSQE...Y.......-ELALDVKAAQSS.INHT----IMGSASFCKKMDAL..S.GG.MSr.nVKNRTSDSIANLLADKFYQKHIDSDVD--I-------vklrnei.................................
D2TM85_CITRI/35-179 .............MGQRRISFSVQKVSDNILSLVTR-QSTK.DIDGWIKDEQKVYPSRVVNQEIDKFC...LENRRNITNNDR......KR.VFAIISKH...Y.......-GLELDSGAAQSS.INHM----IIGNGSFGKKMDNL..C.EG.MTr.nVKNHTSDYMANLLADKFYEKHIE--------------pdvditrlr...............................
Q8X4W3_ECO57/39-185 ............i-GERTISFSVRKFSGNILETVRR-QSTK.DIDEWIKDERIVYPSRVINQEIDNYC...FQKNAKISTEER......QR.VFFLVSQE...N.......-QLTLDVKAAQSS.INHV----IMGSASFGKKMDAL..C.DG.MSr.dVKNRTSDTIANLLADKFYQKHIDSDI-----------divklrnd................................
Q7DB76_ECO57/44-192 ........qsnfv-------INHGKLTNQLLQAVAKQTRNG.DTQQWFQQEQTTYISRTVNRTLDDYC...RSNNSVISKETK......GH.IFRAVENA...L.......-QQPLDMNGAQSS.IGHF----LQSNKYFNQKVDEQ..C.GKrVDpitRFNTQTK-MIEQVSQEIFERNFS-GFKVSE-------ikaitqn.................................
Q8X4Q6_ECO57/39-186 .............MGERSIRFNVNKFSGCILETVSR-QSTK.DIHGWVSDERTVYPSRVINQEIDNCC...LQKNAKISSEER......KM.VFSLVSKE...F.......-ELTLDVKAAQSS.INHI----IIGNASFGKKMDAL..C.DG.MSr.aVKNSTTDYIANVLADKFYQKHIA--------------pgvdivklrnei............................
A0A2U8I374_9GAMM/171-318 .....gnslrldf----------GTIYKDIMKMIREINPGE.YYKQWLEQEKCTYLCALINLQIDRAF...MGH-KQLTKNER......LS.LFKETMHY...Ln.....kSDMTIDIACAQGS.IKHLVSTYLMKNTLFTDFLKRI..-.ND.CD...QKSEVNTKISYALSDLMYESIFKEN------------iissvrkt................................
Q327H0_SHIDS/34-177 .............MGKRIVKISSTKINTSILSSVSE-QIGE.NITDWKNDEKKVYVSRVVNQCIDKFC...AEHSREIGDNLR......KQ.IFKQVEKD...Y.......-RISLDINAAQSS.INHL----VSGSSYFKKKMDEL..C.EG.MNr.sVKNDTTSNVVNLISDQFFEK------NVQYIDLKKLR........................................
IPGB_SHIFL/44-197 ............q-KNFGCPVNINKIRDSVIDKIKDSNSGN.QLFCWMSQERTTYVSSMINRSIDEMA...IHNGVVLTSDNK......KN.IFAAIEKK...F.......PDIKLDEKSAQTS.ISHTALNEIASSGLRAKILKRY..S.SD.MD...LFNTQMKDLTNLVSSSVYDKIFNESTKVLQIEISAEV........................................
Q326S7_SHIDS/44-197 .............HKNFGCPVNINKIRDSVIDKIKDSNSGD.QLFCWMSQERTSYVSSMINRSIDEMA...IHNGVVLTSDNK......KN.IFAAIEKK...F.......PDIKLDEKSAQTS.ISHTALNEIASSGLRAKILKRY..S.SD.MD...LFNTQMKDLTNLVSSSVYDKIFNESTKVLQIEISAEV........................................
D2TKE9_CITRI/43-192 ........vqsnl------MINHDKLTAQLLKAVAK-QTGNgDTQQWFRQEQITFISKTVNKTVDDYC...INNNSTINKETK......QH.IFKAVESV...I.......-QQPLDINCAQSS.ISHF----LQSNKYFNKIVDEQ..CgKG.VDpitRFNTQTK-MIDDVSCELFEKNFN-STKVSDIK-----aitqs...................................
A0A6L2ZQN6_9ENTR/180-344 ........nslpl------PLDVSKIYKDIMKIINEANTVE.FYNQWLKQERNTYICAIINRQIDNAVnqqLNKSINLQREATlykfspKE.RLYLFEKT...MnylninkSDITVDTACAQSS.INHVVLTYLSKNTMISGFLNRE..-.ND.RN...KKNKINTRIAHALSDLIYESIYNKN------------issvrktay...............................
H3RGA5_PANSE/178-329 ...........yk--NNNLELDFTVFYDDIFNHITSFNKGD.HFYLWREEEKETYISSIINKEIDNQL...STKKINLSKNYY......KDyIFNRLKNElgtY.......-NVKLNSKSAQSS.IKHAVLTSLMRNRSFNEFIREN..A.ND.MN...IKNIITTDLVNALSNQIFEDMFID-------------emslprew................................
D2TI21_CITRI/35-184 ............m-GGRSVSFSTDHMNKQILSTVSR-QSTK.DLLAWKKDEKVIYPSRLVNIGIDKYC...AENNTNVTGRVR......QR.VFAMISKD...F.......-GIKLDARSAQSS.INHI----ITGNGSFGKKTASL..C.EG.MDr.gVKNKAADMLANQLADIFFEKNISQDINIKK-------lqndvkr.................................
D2TI15_CITRI/33-185 gtrkisfsylrle--------------SELMQCINLKNEG-.KMNEWMREECICFVSRDVNKQLDIFA...KNNQTTIPGCVR......ER.VFQRASFH...C.......-GFSLDVRCAQTS.THHM----ILNSLYFQKKMDTLfgS.AD.VE...VRNQCVRTALSSLADIFFER------NVNSIDMNK--frdkvydaivqe............................
Q9AJW7_SHIFL/31-174 .............MGKRIVKISSTKINTSILSSVSE-QIGE.NITDWKNDEKKVYVSRVVNQCIDKFC...AEHSRKIGDNLR......KQ.IFKQVEKD...Y.......-RISLDINAAQSS.INHL----VSGSSYFKKKMDEL..C.EG.MNr.sVKNDTTSNVANLISDQFFEK------NVQYIDLKKLR........................................
#=GR Q9AJW7_SHIFL/31-174 SS .............ETTEEEEEEHHHHHHHHHHHHHH-HCSS.THHHHHHHHHHHHHHHHHHHHHHHHH...HHTT----HHHH......HH.HHHHHHHH...H.......-T----TT----H.HHHH----HHT-HHHHHHHHHH..T.TT.B-H.HHHHHHHHHHHHHHHHHHHHH------HT----HHHHH........................................
#=GC SS_cons .............ETTEEEEEEHHHHHHHHHHHHHH-HCSS.THHHHHHHHHHHHHHHHHHHHHHHHH...HHTT----HHHH......HH.HHHHHHHH...H.......-T----TT----H.HHHH----HHT-HHHHHHHHHH..T.TT.B-H.HHHHHHHHHHHHHHHHHHHHH------HT----HHHHH........................................
#=GC seq_cons ....................hshsKhpssllptlsc.pssc.slppWhc-E+psYlS+llNppIDphs...hppsspIoscp+......cp.lFthlp+c...a........plsLDhpuAQSS.IsHh....lhuss.FsKthDcl..s.ss.Ms...lKNppscplsNhluDphaEK.hp................s.....................................
//
