GenomeNet

Database: Pfam
Entry: Izumo-Ig
LinkDB: Izumo-Ig
Original site: Izumo-Ig 
#=GF ID   Izumo-Ig
#=GF AC   PF16706.7
#=GF DE   Izumo-like Immunoglobulin domain
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   [1]
#=GF GA   26.70 26.70;
#=GF TC   26.70 29.00;
#=GF NC   26.60 26.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Immunoglobulin_superfamily
#=GF CL   CL0011
#=GF RN   [1]
#=GF RM   16574441
#=GF RT   The molecular players of sperm-egg fusion in mammals.
#=GF RA   Rubinstein E, Ziyyat A, Wolf JP, Le Naour F, Boucheix C;
#=GF RL   Semin Cell Dev Biol. 2006;17:254-263.
#=GF RN   [2]
#=GF RM   15759005
#=GF RT   The immunoglobulin superfamily protein Izumo is required for
#=GF RT   sperm to fuse with eggs.
#=GF RA   Inoue N, Ikawa M, Isotani A, Okabe M;
#=GF RL   Nature. 2005;434:234-238.
#=GF DR   INTERPRO; IPR032699;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Izumo-Ig is the immunoglobulin domain on Izumo proteins from
#=GF CC   higher eukaryotes. Izumo is a typical type I membrane
#=GF CC   glycoprotein with one immunoglobulin-like domain and a putative
#=GF CC   N-glycoside link motif - glycosylation site. The full-length
#=GF CC   protein, eg Swiss:Q8IYV9, is a molecule with a single
#=GF CC   immunoglobulin (Ig) domain. It is thought that Izumo proteins
#=GF CC   bind to putative Izumo receptors on the oocyte.  Izumo is not
#=GF CC   detectable on the surface of fresh sperm but becomes exposed
#=GF CC   only after an exocytotic process, the acrosome reaction, has
#=GF CC   occurred. Studies have shown that knock-out mice (Izumo-/-
#=GF CC   males) were sterile despite normal mating behaviour and
#=GF CC   ejaculation, indicating the importance of the protein in
#=GF CC   fertilisation [1]. There is a conserved GCL sequence motif.
#=GF CC   Izumo expression has been found to be testis-specific [1,2].
#=GF SQ   169
#=GS A0A5F5XCI6_FELCA/164-251  AC A0A5F5XCI6.1
#=GS A0A2R9A1Y2_PANPA/168-255  AC A0A2R9A1Y2.1
#=GS A0A5F5XN54_FELCA/163-248  AC A0A5F5XN54.1
#=GS A0A2U3WZY4_ODORO/168-255  AC A0A2U3WZY4.1
#=GS A0A2Y9PE52_DELLE/232-319  AC A0A2Y9PE52.1
#=GS A0A455ATP9_PHYMC/71-158   AC A0A455ATP9.1
#=GS V8PHR1_OPHHA/159-245      AC V8PHR1.1
#=GS A0A674HR81_TAEGU/683-727  AC A0A674HR81.1
#=GS A0A1S3G4U8_DIPOR/168-202  AC A0A1S3G4U8.1
#=GS A0A673VGC9_SURSU/168-253  AC A0A673VGC9.1
#=GS A0A6G1A8Y0_CROCR/168-251  AC A0A6G1A8Y0.1
#=GS G1TVX5_RABIT/168-255      AC G1TVX5.1
#=GS A0A4U1FTS2_MONMO/225-312  AC A0A4U1FTS2.1
#=GS M3XLJ0_LATCH/158-246      AC M3XLJ0.1
#=GS A0A5F8GFN4_MONDO/205-293  AC A0A5F8GFN4.1
#=GS A0A671EGI0_RHIFE/168-255  AC A0A671EGI0.1
#=GS A0A673VGM3_SURSU/168-255  AC A0A673VGM3.1
#=GS A0A2I4AR79_9TELE/133-226  AC A0A2I4AR79.1
#=GS IZUM1_HUMAN/168-255       AC Q8IYV9.2
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKE C; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4V A; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4T A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4E A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 D; 168-250;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 C; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 B; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKC A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 F; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKD A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 E; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 A; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKE A; 168-254;
#=GS A0A5F8GDG0_MONDO/205-293  AC A0A5F8GDG0.1
#=GS A0A340XT57_LIPVE/169-256  AC A0A340XT57.1
#=GS A0A341DAW5_NEOAA/169-256  AC A0A341DAW5.1
#=GS A0A2Y9P400_DELLE/225-312  AC A0A2Y9P400.1
#=GS A0A455AUE3_PHYMC/169-244  AC A0A455AUE3.1
#=GS G1M882_AILME/167-254      AC G1M882.1
#=GS A0A3P4PZV3_GULGU/168-255  AC A0A3P4PZV3.1
#=GS G3QFY5_GORGO/168-255      AC G3QFY5.2
#=GS A0A6G1A9N2_CROCR/172-259  AC A0A6G1A9N2.1
#=GS A0A4D9DSM3_9SAUR/146-232  AC A0A4D9DSM3.1
#=GS A0A383YZJ7_BALAS/115-202  AC A0A383YZJ7.1
#=GS A0A3Q7TIP7_VULVU/166-252  AC A0A3Q7TIP7.1
#=GS A0A2K5MSM3_CERAT/168-255  AC A0A2K5MSM3.1
#=GS A0A2Y9PE60_DELLE/169-256  AC A0A2Y9PE60.1
#=GS A0A484DCS2_PERFV/160-256  AC A0A484DCS2.1
#=GS A0A673VHL9_SURSU/171-256  AC A0A673VHL9.1
#=GS A0A6G1AAR5_CROCR/168-255  AC A0A6G1AAR5.1
#=GS A0A673V712_SURSU/168-255  AC A0A673V712.1
#=GS IZUM1_MOUSE/168-255       AC Q9D9J7.1
#=GS IZUM1_MOUSE/168-255       DR PDB; 5B5K A; 168-255;
#=GS A0A6J3QIW9_TURTR/162-249  AC A0A6J3QIW9.1
#=GS L9J9G8_TUPCH/134-218      AC L9J9G8.1
#=GS A0A5F5Y579_FELCA/152-239  AC A0A5F5Y579.1
#=GS H3DD44_TETNG/56-151       AC H3DD44.1
#=GS A0A4X2KXL7_VOMUR/207-294  AC A0A4X2KXL7.1
#=GS A0A287BMD8_PIG/169-256    AC A0A287BMD8.2
#=GS A0A553QS85_9TELE/165-258  AC A0A553QS85.1
#=GS G3HZX1_CRIGR/395-482      AC G3HZX1.1
#=GS E2RRM5_CANLF/1-34         AC E2RRM5.3
#=GS A0A2K6SYH0_SAIBB/168-255  AC A0A2K6SYH0.1
#=GS A0A3Q2KUM8_HORSE/168-255  AC A0A3Q2KUM8.2
#=GS A0A287CWI4_ICTTR/169-256  AC A0A287CWI4.1
#=GS A0A5F5XG39_FELCA/165-250  AC A0A5F5XG39.1
#=GS A0A673VGQ4_SURSU/168-255  AC A0A673VGQ4.1
#=GS A0A2Y9P6M3_DELLE/134-221  AC A0A2Y9P6M3.1
#=GS A0A5J5MUG0_MUNRE/202-289  AC A0A5J5MUG0.1
#=GS A0A6G1A966_CROCR/173-256  AC A0A6G1A966.1
#=GS A0A2U4APR3_TURTR/169-244  AC A0A2U4APR3.1
#=GS C6ZEA2_CAPHI/169-256      AC C6ZEA2.1
#=GS A0A455AS83_PHYMC/232-319  AC A0A455AS83.1
#=GS A0A091D708_FUKDA/184-271  AC A0A091D708.1
#=GS A0A452C6X0_BALAS/71-158   AC A0A452C6X0.1
#=GS A0A3B1K9P2_ASTMX/111-192  AC A0A3B1K9P2.1
#=GS A0A5F5Y1D5_FELCA/152-239  AC A0A5F5Y1D5.1
#=GS A0A2Y9P6L9_DELLE/232-307  AC A0A2Y9P6L9.1
#=GS M7B083_CHEMY/16-89        AC M7B083.1
#=GS A0A5F5XDM7_FELCA/156-235  AC A0A5F5XDM7.1
#=GS A0A2U4APB7_TURTR/169-256  AC A0A2U4APB7.1
#=GS A0A2K5DEP7_AOTNA/168-255  AC A0A2K5DEP7.1
#=GS A0A5F8GJG2_MONDO/205-293  AC A0A5F8GJG2.1
#=GS A0A673V750_SURSU/169-256  AC A0A673V750.1
#=GS A0A1S3AJR4_ERIEU/169-256  AC A0A1S3AJR4.1
#=GS H0WN21_OTOGA/168-255      AC H0WN21.1
#=GS A0A3Q7VIE1_URSAR/168-256  AC A0A3Q7VIE1.1
#=GS A0A5N5NM21_PANHP/166-242  AC A0A5N5NM21.1
#=GS G3TPD8_LOXAF/168-255      AC G3TPD8.1
#=GS A0A2U4APA6_TURTR/162-249  AC A0A2U4APA6.1
#=GS A0A212DBK5_CEREH/162-249  AC A0A212DBK5.1
#=GS A0A341DDB0_NEOAA/169-256  AC A0A341DDB0.1
#=GS A0A2U4APB1_TURTR/169-256  AC A0A2U4APB1.1
#=GS A0A1S3NNQ8_SALSA/160-255  AC A0A1S3NNQ8.1
#=GS A0A1S3NNR7_SALSA/185-280  AC A0A1S3NNR7.1
#=GS A0A6G1A9N1_CROCR/174-261  AC A0A6G1A9N1.1
#=GS A0A2K6NEL4_RHIRO/168-255  AC A0A2K6NEL4.1
#=GS A0A3Q7TNL9_URSAR/143-231  AC A0A3Q7TNL9.1
#=GS A0A3Q7V496_URSAR/168-256  AC A0A3Q7V496.1
#=GS A0A2U4APC4_TURTR/169-256  AC A0A2U4APC4.1
#=GS A0A2K6C510_MACNE/141-228  AC A0A2K6C510.1
#=GS A0A0A0MU86_PAPAN/168-255  AC A0A0A0MU86.2
#=GS A0A2Y9PC54_DELLE/232-318  AC A0A2Y9PC54.1
#=GS A0A673V6R6_SURSU/168-253  AC A0A673V6R6.1
#=GS A0A556UG91_BAGYA/175-245  AC A0A556UG91.1
#=GS A0A6A5FCN3_PERFL/160-255  AC A0A6A5FCN3.1
#=GS H9H653_MONDO/198-286      AC H9H653.3
#=GS A0A2U3YV44_LEPWE/168-255  AC A0A2U3YV44.1
#=GS A0A5F9C4A8_RABIT/168-254  AC A0A5F9C4A8.1
#=GS A0A383YZJ5_BALAS/140-227  AC A0A383YZJ5.1
#=GS IZUM1_RAT/168-255         AC Q6AY06.1
#=GS E1BDA8_BOVIN/169-256      AC E1BDA8.3
#=GS A0A2K6FJK7_PROCO/168-255  AC A0A2K6FJK7.1
#=GS A0A2K5RHC0_CEBCA/141-228  AC A0A2K5RHC0.1
#=GS G1QXF7_NOMLE/168-255      AC G1QXF7.1
#=GS L5L4K5_PTEAL/134-221      AC L5L4K5.1
#=GS A0A3N0YT51_ANAGA/158-251  AC A0A3N0YT51.1
#=GS A0A060Y0K2_ONCMY/179-274  AC A0A060Y0K2.1
#=GS A0A2F0BN51_ESCRO/28-111   AC A0A2F0BN51.1
#=GS A0A673VH43_SURSU/145-230  AC A0A673VH43.1
#=GS A0A1S3G3S8_DIPOR/168-208  AC A0A1S3G3S8.1
#=GS A0A5E4BCK9_MARMO/170-255  AC A0A5E4BCK9.1
#=GS A0A3Q7UBR6_URSAR/168-255  AC A0A3Q7UBR6.1
#=GS A0A2Y9PC44_DELLE/196-283  AC A0A2Y9PC44.1
#=GS A0A341DAW0_NEOAA/219-306  AC A0A341DAW0.1
#=GS A0A3Q7UQT5_VULVU/137-223  AC A0A3Q7UQT5.1
#=GS A0A337SB10_FELCA/153-240  AC A0A337SB10.2
#=GS S9YYW1_CAMFR/162-249      AC S9YYW1.1
#=GS A0A2K5ICP7_COLAP/168-255  AC A0A2K5ICP7.1
#=GS A0A2U4APC0_TURTR/27-114   AC A0A2U4APC0.1
#=GS A0A2Y9P1F4_DELLE/232-319  AC A0A2Y9P1F4.1
#=GS A0A0D9S2Z4_CHLSB/170-257  AC A0A0D9S2Z4.1
#=GS A0A384BKU3_URSMA/168-256  AC A0A384BKU3.1
#=GS A0A1U7QS27_MESAU/168-255  AC A0A1U7QS27.1
#=GS F6XH82_MACMU/168-255      AC F6XH82.1
#=GS A0A5E4BAQ5_MARMO/127-198  AC A0A5E4BAQ5.1
#=GS A0A1S3NNW2_SALSA/125-220  AC A0A1S3NNW2.1
#=GS A0A437CZN9_ORYJA/167-262  AC A0A437CZN9.1
#=GS S7PYD7_MYOBR/162-249      AC S7PYD7.1
#=GS A0A341DBA1_NEOAA/232-319  AC A0A341DBA1.1
#=GS A0A3Q0DGU8_CARSF/55-142   AC A0A3Q0DGU8.1
#=GS A0A455ASF7_PHYMC/162-249  AC A0A455ASF7.1
#=GS A0A4W2ILL7_BOBOX/169-256  AC A0A4W2ILL7.1
#=GS A0A3Q0GZH2_ALLSI/57-141   AC A0A3Q0GZH2.1
#=GS A0A5F8GMC9_MONDO/198-286  AC A0A5F8GMC9.1
#=GS K7DZS4_MONDO/205-293      AC K7DZS4.2
#=GS A0A3Q1DAP6_AMPOC/159-254  AC A0A3Q1DAP6.1
#=GS A0A3Q0GVU8_ALLSI/60-144   AC A0A3Q0GVU8.1
#=GS A0A2Y9L336_ENHLU/282-369  AC A0A2Y9L336.1
#=GS W5PRD0_SHEEP/169-256      AC W5PRD0.1
#=GS A0A452R3V2_URSAM/168-256  AC A0A452R3V2.1
#=GS A0A2K6LQN1_RHIBE/168-255  AC A0A2K6LQN1.1
#=GS A0A2K5DEQ1_AOTNA/168-255  AC A0A2K5DEQ1.1
#=GS A0A2Y9P1F7_DELLE/169-256  AC A0A2Y9P1F7.1
#=GS A0A383YZS1_BALAS/169-244  AC A0A383YZS1.1
#=GS A0A2K6ADS1_MANLE/168-255  AC A0A2K6ADS1.1
#=GS A0A1S3G3D2_DIPOR/168-204  AC A0A1S3G3D2.1
#=GS A0A5A9NZJ4_9TELE/164-256  AC A0A5A9NZJ4.1
#=GS G3VSG5_SARHA/195-279      AC G3VSG5.1
#=GS A0A3L8Q968_CHLGU/44-82    AC A0A3L8Q968.1
#=GS G5BAH6_HETGA/168-255      AC G5BAH6.1
#=GS A0A2Y9GFX2_NEOSC/168-255  AC A0A2Y9GFX2.1
#=GS A0A383YZK9_BALAS/169-256  AC A0A383YZK9.1
#=GS A0A341DAB4_NEOAA/232-319  AC A0A341DAB4.1
#=GS A0A1A6G4T1_NEOLE/121-208  AC A0A1A6G4T1.1
#=GS L5LHN8_MYODS/162-249      AC L5LHN8.1
#=GS A0A315VAD2_GAMAF/206-297  AC A0A315VAD2.1
#=GS A0A287DEN9_ICTTR/162-249  AC A0A287DEN9.1
#=GS A0A2Y9P405_DELLE/232-319  AC A0A2Y9P405.1
#=GS A0A2R8QHQ6_DANRE/165-258  AC A0A2R8QHQ6.1
#=GS A0A2Y9DWR9_TRIMA/168-255  AC A0A2Y9DWR9.1
#=GS A0A1A6GNX2_NEOLE/157-244  AC A0A1A6GNX2.1
#=GS L8IM63_9CETA/169-256      AC L8IM63.1
#=GS A0A096LWR2_POEFO/164-257  AC A0A096LWR2.1
#=GS A0A2K5UGJ7_MACFA/168-255  AC A0A2K5UGJ7.1
#=GS A0A2Y9EZU1_PHYMC/169-256  AC A0A2Y9EZU1.1
#=GS F7H859_CALJA/168-255      AC F7H859.2
#=GS H2QGS4_PANTR/168-255      AC H2QGS4.1
#=GS A0A2U4APA9_TURTR/133-220  AC A0A2U4APA9.1
#=GS G1P6T7_MYOLU/171-258      AC G1P6T7.1
#=GS A0A341DAC0_NEOAA/156-243  AC A0A341DAC0.1
#=GS A0A673V5Q9_SURSU/168-255  AC A0A673V5Q9.1
#=GS A0A4W6C8K3_LATCA/159-254  AC A0A4W6C8K3.1
#=GS A0A498MAL9_LABRO/133-183  AC A0A498MAL9.1
A0A5F5XCI6_FELCA/164-251             .......................RQINVHETEDLILDCELDWHKLSQGLTYYSF........YRVWGS....N.SETLVSEGKRPTLIKRLVRPEDAGNYRCELGTE.RSGPATVIHFEVTVLPK..................
A0A2R9A1Y2_PANPA/168-255             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK..................
A0A5F5XN54_FELCA/163-248             .......................RHINVHEKEDLVLDCELHWHKLSQGLTYYSF........YRVWGS....N.SETLLYKGKRPTLTKPLVGPEDAGNYRCELGIE.RSGPATVIHFEVT----gq................
A0A2U3WZY4_ODORO/168-255             .......................RPVIVHEMEDLILNCELNWHRLSQGLTDYNF........FRVWGR....D.SETLLYKGKNPTLIKTAVTAEDAGVYRCSLDSV.RSIPATIILYEVKVLPK..................
A0A2Y9PE52_DELLE/232-319             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A455ATP9_PHYMC/71-158              .......................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK..................
V8PHR1_OPHHA/159-245                 .......................RKVHVEIDEDLILDCALKWHKASHGVKTYRF........YRMVNN....K.-EKLMASGADSFLTKKEVNMKDAGRYRCKMVDT.KGYTSSQLDFQVVVLP-p.................
A0A674HR81_TAEGU/683-727             .......................RQLWVEEGQDLVLDCALPWHGASHGAKTYSF........YRVSD-....-.---------------------------------.-----------------pspnsagtl.........
A0A1S3G4U8_DIPOR/168-202             ......................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YR----....-.---------------------------------.-----------------gp................
A0A673VGC9_SURSU/168-253             .......................RQVNVHEKEDMILDCELNWHKFSQGLTNYSF........YRVWGS....N.SETLVYSGRRPTLTKPLVGPEDAGNYRCELGTV.RSGPATIIHFQVT----gq................
A0A6G1A8Y0_CROCR/168-251             .......................RRISVYEKDDMNLDCQLDWHTIAEGVTNYSF........YRVWGS....N.SETLMYQGKRPALAKPLVRREDAGNYRCELGTE.RSGPVSIIRFEVT----..................
G1TVX5_RABIT/168-255                 ....................hrs---EVHQMDDLILDCKLSWHQASQGLTDYSF........YRVWGN....N.SETLMAKGKAHLLTKPLVGPEDAGTYRCELGTV.SSGPATIMRFQVTVLP-p.................
A0A4U1FTS2_MONMO/225-312             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
M3XLJ0_LATCH/158-246                 .......................RNISVSEFDSLRLDCSEPWHFKVQNKGLFTFn......vDLAEAG....S.PRTYLFASESPYLVINGITLEHQGTYHCQLTDR.DGDIVSEKRFEVNV---hs................
A0A5F8GFN4_MONDO/205-293             ......................q-AVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTN....G.TEVLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD..................
A0A671EGI0_RHIFE/168-255             .......................RKVKVHEMEDMILDCELNWHHASQGLTDYSF........YRVWRN....K.SETLVSKGKEPTLTKIMVDPLDAGTYRCQLDTV.QSSPATVIRFHVTVLPK..................
A0A673VGM3_SURSU/168-255             .......................RHVNVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....N.SETLVYEGKQPTLTKLLVSPEDAGTYRCELGTV.RSGPATIIHFQVTVLPQ..................
A0A2I4AR79_9TELE/133-226             ......................p--VEAEEGGQAVLNCFVSWHRLLLGNPEYYYswa.petgNKELDE....K.DFTALVVTEDSFVVLNQLHLDEQGTYQCSLRDQ.NGTVFYRVTFLLSVAP-l.................
IZUM1_HUMAN/168-255                  .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK..................
#=GR IZUM1_HUMAN/168-255       SS    .......................EEEEEETTS-EEEE---GGGGGSCSEEEEEE........EEE-TT....S.-EEEEEEES-SEEEESS--GGG-EEEEEEEEES.SSSESEEEEEEEEEEST..................
A0A5F8GDG0_MONDO/205-293             ......................q-AVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTN....G.TEVLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD..................
A0A340XT57_LIPVE/169-256             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATVIYFHVTVLPK..................
A0A341DAW5_NEOAA/169-256             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A2Y9P400_DELLE/225-312             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A455AUE3_PHYMC/169-244             .......................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YR----....-.-------GKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK..................
G1M882_AILME/167-254                 .......................REITVHEMEDLRLNCELSWHRLSQGLASYNF........FRVWGT....K.SETLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.SSGPATIIHYHVRVLPR..................
A0A3P4PZV3_GULGU/168-255             .......................RVVLVHEKEDMILNCELNWHRLSQGLTDYSF........FRVWGQ....N.SETLLSEGKDPILTKTAVTAEDAGVYRCRLGTV.QAIPATVLLFRVTVLPE..................
G3QFY5_GORGO/168-255                 .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVRVLPK..................
A0A6G1A9N2_CROCR/172-259             .......................RQINVHEKEDMILDCELNWHKFSQGLTNYSF........YRVWGS....N.SETLLYKGGRPTLTQRLVMPEDAGNYRCELGTV.RSGPATVIHFQVTVLPE..................
A0A4D9DSM3_9SAUR/146-232             .......................RRLRVQQDDDLILDCALTWHRASYGAKSYRF........YRAAGG....-.SEQVMVMGPDAFLVKKEATANDSGRYRCEMLNA.QGWVCSELRFQVTVTP-l.................
A0A383YZJ7_BALAS/115-202             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....H.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A3Q7TIP7_VULVU/166-252             ......................h-EVVVHELEDLVLDCELSWHRISAGVNNYTF........YRVLGS....N.S-LLLSVGKEPTLTKTMVRLEDAGTYRCELANM.KTSRAGVTHFHVRVLPQ..................
A0A2K5MSM3_CERAT/168-255             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPILTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK..................
A0A2Y9PE60_DELLE/169-256             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A484DCS2_PERFV/160-256             .....................pv---LAEEGGQAVLNCFLPWHRLLLERPEYHYswapgvpgTEKLIE....R.DFKALVVTDDSSVVLNQLHVDEQGTYRCSLLDQ.SGTVFYQVTFLLAV---shlpd.............
A0A673VHL9_SURSU/171-256             .......................RQINVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....N.SETLVYSGRRPTLTKPLVGPEDAGNYRCELGTV.RSGPATIIHFQVT----gq................
A0A6G1AAR5_CROCR/168-255             .......................RQINVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....D.SETLVYKGKQPTLTKPLVRPEDAGNYRCELGTV.QSGPATIIHFQVTVLPQ..................
A0A673V712_SURSU/168-255             .......................RQVNVHEKEDMILDCELNWHKFSQGLTNYSF........YRVWGS....N.SETLVYKGRRPTLTKPLVGPEDAGTYRCELGTV.RSGPATIIHFQVTVLPQ..................
IZUM1_MOUSE/168-255                  .......................RHIEVHRSEDLVLDCLLSWHRASKGLTDYSF........YRVWEN....S.SETLIAKGKEPYLTKSMVGPEDAGNYRCVLDTI.NQGHATVIRYDVTVLP-p.................
#=GR IZUM1_MOUSE/168-255       SS    .......................EEEEEETTS-EEEE---GGGGT-SSEEEEEE........EEE-TT....S.-EEEEEEES-SEEEE-S--GGG-EEEEEEEEES.SS-EEEEEEEEEEEE---.................
A0A6J3QIW9_TURTR/162-249             .......................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
L9J9G8_TUPCH/134-218                 .......................RQVEVYEMEDLILDCELNWHHASQGLTEYSF........YRVWAN....D.SETLVSRKKEPTLTKPMVGPEDEGNYRCELGTV.NSGPATIIYFHVT----g.................
A0A5F5Y579_FELCA/152-239             .......................RQINVHETEDLVLDCELDWHKLSEGLTNYSF........YRVWGS....N.SETLVYKGKRPTLTKPLVGPEDAGTYRCELGTE.RHGPSTIIHFEVTVLPQ..................
H3DD44_TETNG/56-151                  ......................n-TVQAEEGGQAVLDCLQPWHHLLMGRPEYHFswapgvpgTKTVNE....S.NFIVLVVTEDSSLVLNQLRLDEQGTYRCSLQDQ.NETVFYQVHFLLTVAP-l.................
A0A4X2KXL7_VOMUR/207-294             ......................q-SVRVMENGDMVLDCELSWHKAAEGLTDYRF........YRVWPN....G.SEILISRSQESTLIKPMVSLEDSGVYRCILGTVrEHSPATVITYYVKV---dq................
A0A287BMD8_PIG/169-256               .......................RKVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWKN....N.SETLMAKGQEPTLTKTMVSPKDAGTYRCELGTV.QSTPATIIHFHVTVLPK..................
A0A553QS85_9TELE/165-258             ....................qyl---AADEGEEVLLDCLLPWHSLVAGQTEYHYswh..pgeINLTEE....V.EYEELVVTKDSKIVLNQLRVSEGGTYRCLLMDQ.KGTEVSRMHFILKVNP-f.................
G3HZX1_CRIGR/395-482                 .......................RRIEVHRMEDMVLDCQLSWHHASEGLTEYSF........YKVWGN....S.SETLMSKGREPYMTKTMVGPEDAGNYRCELGTI.NAGPATIIHFRVIVL--ga................
E2RRM5_CANLF/1-34                    .......................-------------------------------........------....-.----------------MVRLEDAGTYRCELANM.KTSRAAVTHFRVRVLPQ..................
A0A2K6SYH0_SAIBB/168-255             .......................RNVEVPHMEDMILDCELNWHKASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKPVVGPEDAGDYRCELGTV.NSSPATIILFHVTVLPK..................
A0A3Q2KUM8_HORSE/168-255             .......................RQVKVHRKEDMILDCELNWHRASEGLTDYSF........YRVWGK....N.DETLVSKGKEPTLTKTMVGPEDQGTYRCELGTV.QSDPATIIYFHVTVLPQ..................
A0A287CWI4_ICTTR/169-256             ....................rve---EIHEHEALNLNCFLDWHKEAVGLTNYVF........YRVWEN....N.SETVLYSGKDPVFNRPSASVNDSGKYRCELGTI.YNRPSTIIHFLVTVLPR..................
A0A5F5XG39_FELCA/165-250             .......................RQINVHETEDLILDCELDWHKLSQGLTYYSF........YRVWGS....N.SETLVSEGKRPTLIKRLVRPEDAGNYRCELGTE.RSGPATVIHFEVT----gq................
A0A673VGQ4_SURSU/168-255             .......................RHVNVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....N.SETLVYEGKQPTLTKLLVSPEDAGTYRCELGTV.RSGPATIIHFQVTVLPQ..................
A0A2Y9P6M3_DELLE/134-221             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A5J5MUG0_MUNRE/202-289             .......................REVNVHQMEDMMLDCELNWHKISQGLTDYSF........YRVWKN....N.SETLVSKGKEPILTKTMVRPKDAGTYRCELGSI.KSSPATIIYFHVTVLPK..................
A0A6G1A966_CROCR/173-256             .......................RQINVRELDNMILDCELDWHTIAEGVTNYSF........YRVWGS....N.SETLMYKGKQPAVIKRMMMPVDAGNYRCELGTE.RSGPVSIIRFEVT----..................
A0A2U4APR3_TURTR/169-244             .......................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YR----....-.-------GKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
C6ZEA2_CAPHI/169-256                 .......................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....N.SETLVSRGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK..................
A0A455AS83_PHYMC/232-319             .......................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK..................
A0A091D708_FUKDA/184-271             .......................RSVEVHQMEDMILDCHLNWHQASQGLTDYSF........YRVWGN....N.SETLVSKGKESLLTKPLVGPEDAGDYLCELGTV.SYGPATIINFHVTVLPE..................
A0A452C6X0_BALAS/71-158              .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....H.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A3B1K9P2_ASTMX/111-192             .....................he--LKGQEGEQVVLDCFLSWHSLIIGQAEYHYs......wKRGARN....E.LFEVLVVTEESKIVLNQLSVSEQGVYRCLLLDK.H----------------gtelsrmi..........
A0A5F5Y1D5_FELCA/152-239             .......................RQINVHETEDLVLDCELDWHKLSEGLTNYSF........YRVWGS....N.SETLVYKGKRPTLTKPLVGPEDAGTYRCELGTE.RHGPSTIIHFEVTVLPQ..................
A0A2Y9P6L9_DELLE/232-307             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YR----....-.-------GKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
M7B083_CHEMY/16-89                   yscnrdlrcgaclipvslrqvvg-------------------------------........------....G.VEQVIVTGPDAFLVKKEATVNDSGHYRCEMLNA.QGWVCSKLRFQVTVTP-l.................
A0A5F5XDM7_FELCA/156-235             .......................RQINVHETEDLVLDCELDWHKIATGATGYSF........YRVWGS....K.ADSLLYTGKWPTLTKQLVRPADAGTYRCALGTP.GS---------------aaivtqp...........
A0A2U4APB7_TURTR/169-256             .......................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A2K5DEP7_AOTNA/168-255             .......................RDVEVPRMEDMILDCELNWHKASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKPMVGPEDAGDYRCELDTV.NSSPATIILFHVTVLPK..................
A0A5F8GJG2_MONDO/205-293             ......................q-AVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTN....G.TEVLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD..................
A0A673V750_SURSU/169-256             .......................RQVNVHEKEDMILDCELNWHKLSQGLTSYSF........YRVWGS....N.SETLVYKGRRPTLTKPLVGPEDAGTYRCELGTV.RSGPATIIHFQVTVLPQ..................
A0A1S3AJR4_ERIEU/169-256             .......................REIQVHAMEDLILDCELNWHQASQGLTDYSF........YRVWQN....N.TKTLVSRGKESTLSKPMVDPKDAGTYLCELGTV.QSSPATIIHFHVKVLPK..................
H0WN21_OTOGA/168-255                 .......................RNVEVHEMEDMILDCELSWHRMSQGLSNYRF........YRVWGN....K.SETLVSDGKEPTLTKPMVGAEDAGNYRCELGLV.KSSPATIIHFHVTVLPK..................
A0A3Q7VIE1_URSAR/168-256             .......................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....K.AETLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp.............
A0A5N5NM21_PANHP/166-242             .....................hq--VLANVGEQAVLDCFLPWHSLFS-------........----AE....D.RFEVLVVTKDSKIVLNQLSVSEQGVYRCFLLDQ.HGTTLSHTLFILTVIP-m.................
G3TPD8_LOXAF/168-255                 .......................RQVEVQQMEDMILDCELNWHRASQGLTDYSF........YRVWEN....K.TETLVSKGKEPTLAKPMVGPEDAGTYRCELGTV.KKSPATIIHFRVKVLPR..................
A0A2U4APA6_TURTR/162-249             .......................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A212DBK5_CEREH/162-249             .......................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....N.SETLVSKGKEPILTKTMVRPKDAGTYRCELGSI.KSSPATIIYFHVTVLPK..................
A0A341DDB0_NEOAA/169-256             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A2U4APB1_TURTR/169-256             .......................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A1S3NNQ8_SALSA/160-255             .....................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTE....G.DFRVLVVTEDSSVVLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s.................
A0A1S3NNR7_SALSA/185-280             .....................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTE....G.DFRVLVVTEDSSVVLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s.................
A0A6G1A9N1_CROCR/174-261             .......................RQINVHEKEDMILDCELSWHKLSEGLTNYSF........YRVWGS....N.SETLLYKGKRPTLTKPLVRPEDAGNYRCELGTV.RSSPATIIHFQVTVLPQ..................
A0A2K6NEL4_RHIRO/168-255             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGRYRCELGSV.NSSPATVINFRVTVLPE..................
A0A3Q7TNL9_URSAR/143-231             .......................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....K.AETLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp.............
A0A3Q7V496_URSAR/168-256             .......................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....K.AETLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp.............
A0A2U4APC4_TURTR/169-256             .......................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A2K6C510_MACNE/141-228             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK..................
A0A0A0MU86_PAPAN/168-255             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK..................
A0A2Y9PC54_DELLE/232-318             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVT----gps...............
A0A673V6R6_SURSU/168-253             .......................RQVNVHEKEDMILDCELNWHKFSQGLTNYSF........YRVWGS....N.SETLVYSGRRPTLTKPLVGPEDAGNYRCELGTV.RSGPATIIHFQVT----gq................
A0A556UG91_BAGYA/175-245             ........ffvflfsglcpnkcg-------------------------------........-RFSDD....D.EFETLVVTKDSKIVLNQLSVREQGVYRCFLLGQ.HGITLSHIHFILTVTP-v.................
A0A6A5FCN3_PERFL/160-255             .....................pv---LAEEGGQAVLNCFLPWHRLLLGRPEYHYswvpgvpaTEKLIE....R.DFKALVVTDDSSVVLNQLHVDEQGTYRCSLQDQ.SGTVFYQVTFLLAV---chlp..............
H9H653_MONDO/198-286                 ......................q-AVQVIEKGDLILDCELSWHKKSEGLTDYSF........YKILTN....G.TEVLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD..................
A0A2U3YV44_LEPWE/168-255             ......................r-LVIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGK....D.SETLLSKGKNSTLIKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g.................
A0A5F9C4A8_RABIT/168-254             ....................hrs---EVHQMDDLILDCKLSWHQASQGLTDYSF........YRVWGN....N.SETLMAKGKAHLLTKPLVGPEDAGTYRCELGTV.SSGPATIMRFQVT----gqc...............
A0A383YZJ5_BALAS/140-227             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....H.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
IZUM1_RAT/168-255                    .......................RQIEVHRLEDMVLDCQLSWHHASEGLTDYSF........YRVWGN....S.SETLMSKGKEPYLTKTMVGPEDAGNYRCELDTV.NAGPATIIYYHVTVLP-p.................
E1BDA8_BOVIN/169-256                 .......................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKN....N.SETLVSKGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK..................
A0A2K6FJK7_PROCO/168-255             .......................RKVEVHQMEDMILDCELNWHHASEGLSYYRF........YRVWEN....N.TETLVSMRTAPTLTKPMVGPKDAGRYRCELGSV.NSSPATIIYFNVTVLP-t.................
A0A2K5RHC0_CEBCA/141-228             .......................RNVDVPHMEDMILDCELNWHKASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKPMVGPEDAGDYRCELGTV.NSSPATIIFFHVTVLPK..................
G1QXF7_NOMLE/168-255                 .......................RNVEVPQMEDMMLDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK..................
L5L4K5_PTEAL/134-221                 .......................REVTVHAMEDMILDCELNWHHASEGLTDYSF........FRVWTN....K.SETLVSKGKEPTLTKTMVDSKDAGTYRCQLDTV.QSSPATIIYFNVSVLPK..................
A0A3N0YT51_ANAGA/158-251             ......................h-HLEADEGEEVVLDCFLPWHALVIGQTEYHYswy..peeKNLPHD....G.EYEVLVVTEESKIVLNQLTINEEGTYRCLLQDQ.KGTVLSRMYFKLKV---nqp...............
A0A060Y0K2_ONCMY/179-274             .....................yp--VQAAEGGQAVLDCFLPWHSLVVGRPDYHYtwapgtqrTANLTE....G.DFRVLVVTEDSSVVLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s.................
A0A2F0BN51_ESCRO/28-111              .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....H.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVT----..................
A0A673VH43_SURSU/145-230             .......................RHVNVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....N.SETLVYEGKQPTLTKLLVSPEDAGTYRCELGTV.RSGPATIIHFQVT----gq................
A0A1S3G3S8_DIPOR/168-208             ......................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YRVGSC....-.---------------------------------.-----------------nssk..............
A0A5E4BCK9_MARMO/170-255             .......................RLVKVHEKENLTLNCLFEWHPLSVGLTDYQF........YRITED....G.SEKLLYKGKNPMLTIPSVNPDNSGSYRCELGSV.SSGPATIFHYLVT----ee................
A0A3Q7UBR6_URSAR/168-255             .......................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....K.AETLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVRVLPR..................
A0A2Y9PC44_DELLE/196-283             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A341DAW0_NEOAA/219-306             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A3Q7UQT5_VULVU/137-223             ......................h-EVVVHELEDLVLDCELSWHRISAGVNNYTF........YRVLGS....N.S-LLLSVGKEPTLTKTMVRLEDAGTYRCELANM.KTSRAGVTHFHVRVLPQ..................
A0A337SB10_FELCA/153-240             .......................RHINVHEKEDLVLDCELHWHKLSQGLTYYSF........YRVWGS....N.SETLVYKGKQPTLTKPLVGPEDAGDYRCELGTV.RSLPATVIHFKVTVLPQ..................
S9YYW1_CAMFR/162-249                 .......................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGIQPTLTKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK..................
A0A2K5ICP7_COLAP/168-255             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK..................
A0A2U4APC0_TURTR/27-114              .......................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A2Y9P1F4_DELLE/232-319             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A0D9S2Z4_CHLSB/170-257             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK..................
A0A384BKU3_URSMA/168-256             .......................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....K.AETLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp.............
A0A1U7QS27_MESAU/168-255             .......................RRIEVHRLEDLVLDCQLSWHHASEGLTDYSF........YRVWGN....S.SETLLSKGKEPYMTKSMVGPEDAGNYRCELGTV.NAGPATIIHFRVIVLPQ..................
F6XH82_MACMU/168-255                 .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK..................
A0A5E4BAQ5_MARMO/127-198             .........ckkkteecggeswt------------------------------R........WGVWEN....D.SETELYRGKDPVFNRPSASVNDSGRYRCELGTV.YNRPSTIIHFLVTVLPR..................
A0A1S3NNW2_SALSA/125-220             .....................yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTE....G.DFRVLVVTEDSSVVLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s.................
A0A437CZN9_ORYJA/167-262             .....................tp--VQAEEGGQVVFSCYQPWHYLISGKPEYYYswapvvpgTKKLNE....S.DFVPLVVTHDSSVVLNQLQLDEQGTYRCSLQEE.NRTVFYQVTFLLTVTP-l.................
S7PYD7_MYOBR/162-249                 .......................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKN....K.PESMVYKGTAPTLTKTKATPSDAGTYRCQLNTV.NNSPATIIRYHVRVLPK..................
A0A341DBA1_NEOAA/232-319             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A3Q0DGU8_CARSF/55-142              .......................RRVKVHQMEDMILDCEFNWHRASEGLTDYSF........YRVWGN....H.SETLVSKGKEPTLTKPMVGQEDAGSYRCELGTV.TSEPGLLFDPSLPVLPK..................
A0A455ASF7_PHYMC/162-249             .......................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK..................
A0A4W2ILL7_BOBOX/169-256             .......................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKN....N.SETLVSKGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK..................
A0A3Q0GZH2_ALLSI/57-141              .......................RKLEVEEDEDLILDCALTWHHVSYGIKNYIF........YRVWGH....T.EQ-HIVSGPDPFLVRKEVTVNDSGSYRCEMRDA.KNMLCSQMQFQVT----ge................
A0A5F8GMC9_MONDO/198-286             ......................q-AVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTN....G.TEVLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD..................
K7DZS4_MONDO/205-293                 ......................q-AVQVIEKGDLILDCELSWHKKSEGLTDYSF........YKILTN....G.TEVLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD..................
A0A3Q1DAP6_AMPOC/159-254             .....................hp--VQAEEGGQAVLDCFLPWHRLLLGKPEYHYfwapgapgTETLDE....S.DFKALVVTDDSSVVLNQLRVDEQGTYRCSLQDR.NGTIFYQITFLLTVAP-l.................
A0A3Q0GVU8_ALLSI/60-144              .......................RKLEVEEDEDLILDCALTWHHVSYGIKNYIF........YRVWGH....T.EQ-HIVSGPDPFLVRKEVTVNDSGSYRCEMRDA.KNMLCSQMQFQVT----ge................
A0A2Y9L336_ENHLU/282-369             .......................RVVLVHEKEDMILNCELNWHRLSQGLTNYSF........FRVWGQ....N.SETLLSEGKDPILTKTAVTAEDAGVYRCRLGTV.RSIPATILFFRVTVLPE..................
W5PRD0_SHEEP/169-256                 .......................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....N.SETLVSRGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK..................
A0A452R3V2_URSAM/168-256             .......................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....K.AETLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVR----glllp.............
A0A2K6LQN1_RHIBE/168-255             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGRYRCELGSV.NSSPATVINFRVTVLPE..................
A0A2K5DEQ1_AOTNA/168-255             .......................RDVEVPRMEDMILDCELNWHKASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKPMVGPEDAGDYRCELDTV.NSSPATIILFHVTVLPK..................
A0A2Y9P1F7_DELLE/169-256             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A383YZS1_BALAS/169-244             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YR----....-.-------GKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A2K6ADS1_MANLE/168-255             .......................RSVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK..................
A0A1S3G3D2_DIPOR/168-204             ......................h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YRA---....-.---------------------------------.-----------------svt...............
A0A5A9NZJ4_9TELE/164-256             .....................hh--LEADEGVGVVLDCFLPWHTLVVGQTEYYYsw....lpAKNLSH....KgEYEELVVTEDSKIVLNQLRVNEQGVYRCLLQDQ.KKTTLSRIYFYLKVNP-l.................
G3VSG5_SARHA/195-279                 .....................qy--VRVPKNGDMVLDCELSWHKAAEGLTYYHF........YRVWPN....H.SEVLISRGRDPALTKPMVSLEDAGDYRCILGTVrRRNPATVITYHV-----a.................
A0A3L8Q968_CHLGU/44-82               .......................RQLWVEEGQDLVLDCALPWHGASHGAKTYSF........YRGL--....-.---------------------------------.-----------------aaag..............
G5BAH6_HETGA/168-255                 .......................RNVEVHEMEDMILDCHLNWHQASQGLTDYSF........YRVWGN....N.SETLESKGKESLLTKPLVGPEDAGDYRCELGTV.SYGPATIIYFHVTVLPK..................
A0A2Y9GFX2_NEOSC/168-255             ......................r-LVIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGK....D.SETLLSKGKNSTLIKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g.................
A0A383YZK9_BALAS/169-256             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....H.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A341DAB4_NEOAA/232-319             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A1A6G4T1_NEOLE/121-208             .......................RRIEVPQLEDTVLDCQLSWHHASEGLTDYSF........YRVWGN....S.SETLLSKGKKPYLTKTRVGPEDAGNYRCELGTI.NSGPATIIHFRVIVLPQ..................
L5LHN8_MYODS/162-249                 .......................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKN....K.SESMVYKGTAPTLTKARAKPSDAGTYRCQLNTV.KNSPATIIRYHVRVLPK..................
A0A315VAD2_GAMAF/206-297             .....................hl--VQAEEEGQAVLNCFLPWHRFLLGRPEYHY........SRAIGEpdaiK.DFQLLVVTQDASIVLNQLHLDEQGTYRCSLQDE.NGAVYYRASFLLTVEP-l.................
A0A287DEN9_ICTTR/162-249             ....................rve---EIHEHEALNLNCFLDWHKEAVGLTNYVF........YRVWEN....N.SETVLYSGKDPVFNRPSASVNDSGKYRCELGTI.YNRPSTIIHFLVTVLPR..................
A0A2Y9P405_DELLE/232-319             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A2R8QHQ6_DANRE/165-258             ......................h-HLEADEGEEVVLDCFLSWHTLVVGQTEYHYswh..pgeTNVLFD....G.EYEELVVTKESKIVLNQLSVSEEGSYRCLLKDQ.KGTALSRTFFQLEVKP-f.................
A0A2Y9DWR9_TRIMA/168-255             .......................RQVEVQQMQDMILDCELNWHRASQGLTDYSF........YRVWEN....K.TETLVSKGKDPILAKPMVGPEDAGTYRCELGTV.NNSPATIIHFHVKVLPK..................
A0A1A6GNX2_NEOLE/157-244             .......................RRVEVPQMEDMVLDCQLSWHHASEGLTDYSF........YRVWGN....S.SETLLSKGKEPYMTKIMVSPEDAGNYRCELGTI.NSGPATIIHFRVIVLPK..................
L8IM63_9CETA/169-256                 .......................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKN....N.SETLVSKGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK..................
A0A096LWR2_POEFO/164-257             .....................hl--VQAEEGGQAVLNCFLPWHRFLLGKPEYHYsra..tdlYTQLTE....K.DFQPLVVTQDASIVLNQLHLDEQGTYRCSLQDE.NGAVYYRASFQLTVKP-l.................
A0A2K5UGJ7_MACFA/168-255             .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK..................
A0A2Y9EZU1_PHYMC/169-256             .......................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK..................
F7H859_CALJA/168-255                 .......................RDVEVPHMEDMTLDCELNWHKASEGLTDYSF........YRVWGN....N.TETLVSKGKESTLTKPMVGPEDAGDYRCELGTV.NSSPATIILFHVTVLPK..................
H2QGS4_PANTR/168-255                 .......................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....N.TETLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPR..................
A0A2U4APA9_TURTR/133-220             .......................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
G1P6T7_MYOLU/171-258                 .......................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKN....K.PESMVYKGTAPTLTKTKANPSDAGTYRCQLNTV.KNSPATIIRYHVRVLPK..................
A0A341DAC0_NEOAA/156-243             .......................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....N.SETLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK..................
A0A673V5Q9_SURSU/168-255             .....................qy--VNVHEKEDMILDCELSWHKLSEGLTNYSF........YKVWGS....N.SEALMYTGTRPTLIKPLVGPEDAGLYRCELGTV.RSGPATIIHFEVTVLPQ..................
A0A4W6C8K3_LATCA/159-254             .....................yp--VQAEEGGQAVLNCFLPWHRLLLGKPEYHYswapgvpgTKKLDE....S.HFKSLVVTEDSSVVLNQLHVDEQGTYRCSLQGQ.NGAVFYRATFLLTA---mts...............
A0A498MAL9_LABRO/133-183             .......................RHVEADEGEEVVLDCFLPWHALVVGQTEYHY........SW----....-.---------------------------------.-----------------hpreknvhahrqtntfsa
#=GC SS_cons                         .......................EEEEEETTS-EEEE---GGGGCSCSEEEEEE........EEE-TT....S.-EEEEEEES-SEEEESS--GGG-EEEEEEEEES.SSSECEEEEEEEEEEST-.................
#=GC seq_cons                        .......................RpVcVHphEDhILDCELsWH+hSpGLT-YSF........YRVWGs....s.oETLls+GK-PTLTKshVpPcDAGoYRCELGoV.pSoPATIIaF+VTVLPp..................
//
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