GenomeNet

Database: Pfam
Entry: Izumo-Ig
LinkDB: Izumo-Ig
Original site: Izumo-Ig 
#=GF ID   Izumo-Ig
#=GF AC   PF16706.8
#=GF DE   Izumo-like Immunoglobulin domain
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   [1]
#=GF GA   26.70 26.70;
#=GF TC   26.70 28.20;
#=GF NC   26.60 26.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Immunoglobulin_superfamily
#=GF CL   CL0011
#=GF RN   [1]
#=GF RM   16574441
#=GF RT   The molecular players of sperm-egg fusion in mammals.
#=GF RA   Rubinstein E, Ziyyat A, Wolf JP, Le Naour F, Boucheix C;
#=GF RL   Semin Cell Dev Biol. 2006;17:254-263.
#=GF RN   [2]
#=GF RM   15759005
#=GF RT   The immunoglobulin superfamily protein Izumo is required for
#=GF RT   sperm to fuse with eggs.
#=GF RA   Inoue N, Ikawa M, Isotani A, Okabe M;
#=GF RL   Nature. 2005;434:234-238.
#=GF DR   INTERPRO; IPR032699;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Izumo-Ig is the immunoglobulin domain on Izumo proteins from
#=GF CC   higher eukaryotes. Izumo is a typical type I membrane
#=GF CC   glycoprotein with one immunoglobulin-like domain and a putative
#=GF CC   N-glycoside link motif - glycosylation site. The full-length
#=GF CC   protein, eg Swiss:Q8IYV9, is a molecule with a single
#=GF CC   immunoglobulin (Ig) domain. It is thought that Izumo proteins
#=GF CC   bind to putative Izumo receptors on the oocyte.  Izumo is not
#=GF CC   detectable on the surface of fresh sperm but becomes exposed
#=GF CC   only after an exocytotic process, the acrosome reaction, has
#=GF CC   occurred. Studies have shown that knock-out mice (Izumo-/-
#=GF CC   males) were sterile despite normal mating behaviour and
#=GF CC   ejaculation, indicating the importance of the protein in
#=GF CC   fertilisation [1]. There is a conserved GCL sequence motif.
#=GF CC   Izumo expression has been found to be testis-specific [1,2].
#=GF SQ   245
#=GS A0A5F5XCI6_FELCA/164-251  AC A0A5F5XCI6.1
#=GS A0A2R9A1Y2_PANPA/168-255  AC A0A2R9A1Y2.1
#=GS A0A2U3WZY4_ODORO/168-255  AC A0A2U3WZY4.1
#=GS A0A2Y9PE52_DELLE/232-319  AC A0A2Y9PE52.1
#=GS A0A6P7NPL2_BETSP/159-253  AC A0A6P7NPL2.1
#=GS A0A6J3ATE0_VICPA/133-220  AC A0A6J3ATE0.1
#=GS A0A455ATP9_PHYMC/71-158   AC A0A455ATP9.1
#=GS V8PHR1_OPHHA/159-245      AC V8PHR1.1
#=GS A0A6P9BVY0_PANGU/131-217  AC A0A6P9BVY0.1
#=GS A0A674HR81_TAEGU/683-727  AC A0A674HR81.1
#=GS A0A6J3AWG2_VICPA/144-231  AC A0A6J3AWG2.1
#=GS A0A1S3G4U8_DIPOR/168-202  AC A0A1S3G4U8.1
#=GS A0A6G1A8Y0_CROCR/168-251  AC A0A6G1A8Y0.1
#=GS G1TVX5_RABIT/168-255      AC G1TVX5.1
#=GS A0A4U1FTS2_MONMO/225-312  AC A0A4U1FTS2.1
#=GS A0A5F8GFN4_MONDO/205-293  AC A0A5F8GFN4.1
#=GS A0A671EGI0_RHIFE/168-255  AC A0A671EGI0.1
#=GS A0A6P8SUL3_GEOSA/161-247  AC A0A6P8SUL3.1
#=GS A0A673VGM3_SURSU/168-255  AC A0A673VGM3.1
#=GS A0A2I4AR79_9TELE/133-226  AC A0A2I4AR79.1
#=GS IZUM1_HUMAN/168-255       AC Q8IYV9.2
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKE C; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4V A; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4T A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5F4E A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 D; 168-250;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 C; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 B; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKC A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 F; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKD A; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 E; 168-254;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JK9 A; 168-255;
#=GS IZUM1_HUMAN/168-255       DR PDB; 5JKE A; 168-254;
#=GS A0A6I9MKP5_9TELE/160-255  AC A0A6I9MKP5.1
#=GS A0A5F8GDG0_MONDO/205-293  AC A0A5F8GDG0.1
#=GS A0A340XT57_LIPVE/169-256  AC A0A340XT57.1
#=GS A0A341DAW5_NEOAA/169-256  AC A0A341DAW5.1
#=GS A0A2Y9P400_DELLE/225-312  AC A0A2Y9P400.1
#=GS A0A6P5LSV0_PHACI/222-281  AC A0A6P5LSV0.1
#=GS A0A455AUE3_PHYMC/169-244  AC A0A455AUE3.1
#=GS A0A3P4PZV3_GULGU/168-255  AC A0A3P4PZV3.1
#=GS G3QFY5_GORGO/168-255      AC G3QFY5.2
#=GS A0A6G1A9N2_CROCR/172-259  AC A0A6G1A9N2.1
#=GS A0A4D9DSM3_9SAUR/146-232  AC A0A4D9DSM3.1
#=GS A0A383YZJ7_BALAS/115-202  AC A0A383YZJ7.1
#=GS A0A3Q7TIP7_VULVU/166-252  AC A0A3Q7TIP7.1
#=GS A0A2K5MSM3_CERAT/168-255  AC A0A2K5MSM3.1
#=GS A0A6J2UNE1_CHACN/165-258  AC A0A6J2UNE1.1
#=GS A0A2Y9PE60_DELLE/169-256  AC A0A2Y9PE60.1
#=GS A0A6G1AAR5_CROCR/168-255  AC A0A6G1AAR5.1
#=GS A0A673V712_SURSU/168-255  AC A0A673V712.1
#=GS A0A6I9K3Q9_CHRAS/168-255  AC A0A6I9K3Q9.1
#=GS IZUM1_MOUSE/168-255       AC Q9D9J7.1
#=GS IZUM1_MOUSE/168-255       DR PDB; 5B5K A; 168-255;
#=GS A0A6J0U8M1_9SAUR/166-252  AC A0A6J0U8M1.1
#=GS A0A6J3QIW9_TURTR/162-249  AC A0A6J3QIW9.1
#=GS A0A5F5Y579_FELCA/152-239  AC A0A5F5Y579.1
#=GS A0A6P6BLH4_PTEVA/168-255  AC A0A6P6BLH4.1
#=GS A0A3Q0GZH2_ALLSI/57-142   AC A0A3Q0GZH2.1
#=GS A0A7N6AM00_ANATE/159-253  AC A0A7N6AM00.1
#=GS A0A6P8VNK4_GYMAC/160-255  AC A0A6P8VNK4.1
#=GS H3DD44_TETNG/56-151       AC H3DD44.1
#=GS A0A287BMD8_PIG/169-256    AC A0A287BMD8.2
#=GS A0A553QS85_9TELE/165-258  AC A0A553QS85.1
#=GS A0A6J2QBP9_COTGO/159-254  AC A0A6J2QBP9.1
#=GS A0A673V6R6_SURSU/168-254  AC A0A673V6R6.1
#=GS G3HZX1_CRIGR/395-482      AC G3HZX1.1
#=GS A0A384BKU3_URSMA/168-255  AC A0A384BKU3.1
#=GS A0A6J1Z0K8_ACIJB/1-55     AC A0A6J1Z0K8.1
#=GS E2RRM5_CANLF/1-34         AC E2RRM5.3
#=GS A0A6P7J2G5_9TELE/160-255  AC A0A6P7J2G5.1
#=GS A0A2K6SYH0_SAIBB/168-255  AC A0A2K6SYH0.1
#=GS A0A3Q2KUM8_HORSE/168-255  AC A0A3Q2KUM8.2
#=GS A0A6P6MTI4_CARAU/189-282  AC A0A6P6MTI4.1
#=GS A0A287CWI4_ICTTR/169-256  AC A0A287CWI4.1
#=GS A0A6P9C876_PANGU/156-242  AC A0A6P9C876.1
#=GS A0A6J1XMY2_ACIJB/168-208  AC A0A6J1XMY2.1
#=GS A0A673VGQ4_SURSU/168-255  AC A0A673VGQ4.1
#=GS A0A6P5LLE6_PHACI/176-264  AC A0A6P5LLE6.1
#=GS A0A673VH43_SURSU/145-231  AC A0A673VH43.1
#=GS A0A2Y9P6M3_DELLE/134-221  AC A0A2Y9P6M3.1
#=GS A0A6J0X3U2_ODOVR/169-256  AC A0A6J0X3U2.1
#=GS A0A5J5MUG0_MUNRE/202-289  AC A0A5J5MUG0.1
#=GS A0A6G1A966_CROCR/173-256  AC A0A6G1A966.1
#=GS A0A2U4APR3_TURTR/169-244  AC A0A2U4APR3.1
#=GS C6ZEA2_CAPHI/169-256      AC C6ZEA2.1
#=GS A0A455AS83_PHYMC/232-319  AC A0A455AS83.1
#=GS A0A091D708_FUKDA/184-271  AC A0A091D708.1
#=GS A0A452C6X0_BALAS/71-158   AC A0A452C6X0.1
#=GS A0A6P7NPS1_BETSP/135-229  AC A0A6P7NPS1.1
#=GS A0A452R3V2_URSAM/168-255  AC A0A452R3V2.1
#=GS A0A3B1K9P2_ASTMX/111-192  AC A0A3B1K9P2.1
#=GS A0A5F5Y1D5_FELCA/152-239  AC A0A5F5Y1D5.1
#=GS A0A2Y9P6L9_DELLE/232-307  AC A0A2Y9P6L9.1
#=GS A0A6J1XMR2_ACIJB/161-201  AC A0A6J1XMR2.1
#=GS A0A6J0X0P0_ODOVR/169-233  AC A0A6J0X0P0.1
#=GS A0A5F5XDM7_FELCA/156-235  AC A0A5F5XDM7.1
#=GS A0A2U4APB7_TURTR/169-256  AC A0A2U4APB7.1
#=GS A0A2K5DEP7_AOTNA/168-255  AC A0A2K5DEP7.1
#=GS A0A5F8GJG2_MONDO/205-293  AC A0A5F8GJG2.1
#=GS A0A6J1XMV9_ACIJB/136-176  AC A0A6J1XMV9.1
#=GS A0A1S3AJR4_ERIEU/169-256  AC A0A1S3AJR4.1
#=GS A0A673V750_SURSU/169-256  AC A0A673V750.1
#=GS A0A3Q7TNL9_URSAR/143-230  AC A0A3Q7TNL9.1
#=GS H0WN21_OTOGA/168-255      AC H0WN21.1
#=GS A0A6J3AXH3_VICPA/162-249  AC A0A6J3AXH3.1
#=GS A0A5N5NM21_PANHP/166-242  AC A0A5N5NM21.1
#=GS G3TPD8_LOXAF/168-255      AC G3TPD8.1
#=GS A0A2U4APA6_TURTR/162-249  AC A0A2U4APA6.1
#=GS A0A212DBK5_CEREH/162-249  AC A0A212DBK5.1
#=GS A0A341DDB0_NEOAA/169-256  AC A0A341DDB0.1
#=GS M7B083_CHEMY/23-89        AC M7B083.1
#=GS A0A2U4APB1_TURTR/169-256  AC A0A2U4APB1.1
#=GS A0A1S3NNR7_SALSA/185-280  AC A0A1S3NNR7.1
#=GS A0A1S3NNQ8_SALSA/160-255  AC A0A1S3NNQ8.1
#=GS A0A5E4BCK9_MARMO/170-256  AC A0A5E4BCK9.1
#=GS A0A6G1A9N1_CROCR/174-261  AC A0A6G1A9N1.1
#=GS A0A2K6NEL4_RHIRO/168-255  AC A0A2K6NEL4.1
#=GS A0A6P6H407_PUMCO/169-256  AC A0A6P6H407.1
#=GS A0A2U4APC4_TURTR/169-256  AC A0A2U4APC4.1
#=GS A0A2K6C510_MACNE/141-228  AC A0A2K6C510.1
#=GS A0A0A0MU86_PAPAN/168-255  AC A0A0A0MU86.2
#=GS A0A7F8K902_DELLE/162-249  AC A0A7F8K902.1
#=GS A0A2Y9PC54_DELLE/232-318  AC A0A2Y9PC54.1
#=GS A0A6I9IF17_VICPA/169-256  AC A0A6I9IF17.1
#=GS A0A6J1Z0B5_ACIJB/48-135   AC A0A6J1Z0B5.1
#=GS H9H653_MONDO/198-286      AC H9H653.3
#=GS A0A6P6H306_PUMCO/60-147   AC A0A6P6H306.1
#=GS A0A6P5LS24_PHACI/149-214  AC A0A6P5LS24.1
#=GS A0A6P6H2P4_PUMCO/55-142   AC A0A6P6H2P4.1
#=GS A0A2U3YV44_LEPWE/168-255  AC A0A2U3YV44.1
#=GS A0A383YZJ5_BALAS/140-227  AC A0A383YZJ5.1
#=GS IZUM1_RAT/168-255         AC Q6AY06.1
#=GS E1BDA8_BOVIN/169-256      AC E1BDA8.3
#=GS A0A6J2N838_9CHIR/168-255  AC A0A6J2N838.1
#=GS A0A2K6FJK7_PROCO/168-255  AC A0A2K6FJK7.1
#=GS A0A6P7NJD8_BETSP/159-253  AC A0A6P7NJD8.1
#=GS A0A484DCS2_PERFV/160-255  AC A0A484DCS2.1
#=GS A0A6P7NJU8_BETSP/152-246  AC A0A6P7NJU8.1
#=GS A0A2K5RHC0_CEBIM/141-228  AC A0A2K5RHC0.1
#=GS A0A6J3AZC8_VICPA/169-256  AC A0A6J3AZC8.1
#=GS A0A673VGC9_SURSU/168-254  AC A0A673VGC9.1
#=GS A0A6J1XMP6_ACIJB/143-183  AC A0A6J1XMP6.1
#=GS G1QXF7_NOMLE/168-255      AC G1QXF7.1
#=GS A0A3Q7MFL5_CALUR/168-255  AC A0A3Q7MFL5.1
#=GS L5L4K5_PTEAL/134-221      AC L5L4K5.1
#=GS A0A6A5FCN3_PERFL/160-254  AC A0A6A5FCN3.1
#=GS A0A3N0YT51_ANAGA/158-251  AC A0A3N0YT51.1
#=GS A0A060Y0K2_ONCMY/179-274  AC A0A060Y0K2.1
#=GS A0A7F8K6G4_DELLE/162-249  AC A0A7F8K6G4.1
#=GS A0A2F0BN51_ESCRO/28-111   AC A0A2F0BN51.1
#=GS M3XLJ0_LATCH/158-247      AC M3XLJ0.1
#=GS A0A556UG91_BAGYA/176-245  AC A0A556UG91.1
#=GS A0A4X2KXL7_VOMUR/207-295  AC A0A4X2KXL7.1
#=GS A0A6J1Z1H6_ACIJB/55-142   AC A0A6J1Z1H6.1
#=GS A0A6J0X3S4_ODOVR/162-249  AC A0A6J0X3S4.1
#=GS A0A1S3G3S8_DIPOR/168-208  AC A0A1S3G3S8.1
#=GS A0A3Q7UBR6_URSAR/168-255  AC A0A3Q7UBR6.1
#=GS A0A2Y9PC44_DELLE/196-283  AC A0A2Y9PC44.1
#=GS A0A341DAW0_NEOAA/219-306  AC A0A341DAW0.1
#=GS A0A337SB10_FELCA/153-240  AC A0A337SB10.2
#=GS A0A3Q7UQT5_VULVU/137-223  AC A0A3Q7UQT5.1
#=GS A0A5E4BAQ5_MARMO/128-198  AC A0A5E4BAQ5.1
#=GS S9YYW1_CAMFR/162-249      AC S9YYW1.1
#=GS A0A2K5ICP7_COLAP/168-255  AC A0A2K5ICP7.1
#=GS A0A2Y9P1F4_DELLE/232-319  AC A0A2Y9P1F4.1
#=GS A0A2U4APC0_TURTR/27-114   AC A0A2U4APC0.1
#=GS A0A0D9S2Z4_CHLSB/170-257  AC A0A0D9S2Z4.1
#=GS A0A674K1A9_TERCA/168-254  AC A0A674K1A9.1
#=GS A0A1U7QS27_MESAU/168-255  AC A0A1U7QS27.1
#=GS A0A6I9MYB6_9TELE/160-255  AC A0A6I9MYB6.1
#=GS A0A6P5LNW2_PHACI/120-185  AC A0A6P5LNW2.1
#=GS A0A6J3AWG9_VICPA/108-195  AC A0A6J3AWG9.1
#=GS F6XH82_MACMU/168-255      AC F6XH82.1
#=GS L9J9G8_TUPCH/134-220      AC L9J9G8.1
#=GS A0A6I9MZ79_9TELE/132-227  AC A0A6I9MZ79.1
#=GS A0A6P3FGL4_OCTDE/168-255  AC A0A6P3FGL4.1
#=GS A0A6P5LNV6_PHACI/251-310  AC A0A6P5LNV6.1
#=GS A0A6P9C7A7_PANGU/56-142   AC A0A6P9C7A7.1
#=GS A0A1S3NNW2_SALSA/125-220  AC A0A1S3NNW2.1
#=GS A0A5F5XN54_FELCA/163-249  AC A0A5F5XN54.1
#=GS A0A437CZN9_ORYJA/167-262  AC A0A437CZN9.1
#=GS S7PYD7_MYOBR/162-249      AC S7PYD7.1
#=GS A0A7F8Q173_LEPWE/141-228  AC A0A7F8Q173.1
#=GS A0A6P6MVD5_CARAU/165-258  AC A0A6P6MVD5.1
#=GS A0A341DBA1_NEOAA/232-319  AC A0A341DBA1.1
#=GS A0A3Q0DGU8_CARSF/55-142   AC A0A3Q0DGU8.1
#=GS A0A455ASF7_PHYMC/162-249  AC A0A455ASF7.1
#=GS G1M882_AILME/161-248      AC G1M882.2
#=GS A0A6P5LS24_PHACI/224-283  AC A0A6P5LS24.1
#=GS A0A6P5LSV0_PHACI/147-212  AC A0A6P5LSV0.1
#=GS A0A4W2ILL7_BOBOX/169-256  AC A0A4W2ILL7.1
#=GS A0A7F8PYY1_LEPWE/143-230  AC A0A7F8PYY1.1
#=GS A0A5F8GMC9_MONDO/198-286  AC A0A5F8GMC9.1
#=GS A0A6P9BWS1_PANGU/156-229  AC A0A6P9BWS1.1
#=GS A0A6P5LNV6_PHACI/176-241  AC A0A6P5LNV6.1
#=GS K7DZS4_MONDO/205-293      AC K7DZS4.2
#=GS A0A3Q1DAP6_AMPOC/159-254  AC A0A3Q1DAP6.1
#=GS A0A2Y9L336_ENHLU/282-369  AC A0A2Y9L336.1
#=GS A0A6P5DD34_BOSIN/169-256  AC A0A6P5DD34.1
#=GS A0A3Q7VIE1_URSAR/168-255  AC A0A3Q7VIE1.1
#=GS A0A2K5UGJ7_MACFA/201-288  AC A0A2K5UGJ7.2
#=GS W5PRD0_SHEEP/169-256      AC W5PRD0.1
#=GS A0A6P5LNW2_PHACI/195-254  AC A0A6P5LNW2.1
#=GS A0A6P7J359_9TELE/130-225  AC A0A6P7J359.1
#=GS A0A5F5XG39_FELCA/165-251  AC A0A5F5XG39.1
#=GS A0A2K6LQN1_RHIBE/168-255  AC A0A2K6LQN1.1
#=GS A0A6P8FUG8_CLUHA/193-286  AC A0A6P8FUG8.1
#=GS A0A2K5DEQ1_AOTNA/168-255  AC A0A2K5DEQ1.1
#=GS A0A2Y9P1F7_DELLE/169-256  AC A0A2Y9P1F7.1
#=GS A0A2K6ADS1_MANLE/168-255  AC A0A2K6ADS1.1
#=GS A0A7N5P678_AILME/168-210  AC A0A7N5P678.1
#=GS A0A383YZS1_BALAS/169-244  AC A0A383YZS1.1
#=GS A0A6P7NR48_BETSP/129-223  AC A0A6P7NR48.1
#=GS A0A6P6H2T4_PUMCO/168-255  AC A0A6P6H2T4.1
#=GS A0A3Q7MFG9_CALUR/168-255  AC A0A3Q7MFG9.1
#=GS A0A5F9C4A8_RABIT/168-255  AC A0A5F9C4A8.1
#=GS A0A6J0X5E9_ODOVR/169-256  AC A0A6J0X5E9.1
#=GS A0A3Q7V496_URSAR/168-255  AC A0A3Q7V496.1
#=GS A0A1S3G3D2_DIPOR/168-204  AC A0A1S3G3D2.1
#=GS A0A5A9NZJ4_9TELE/164-256  AC A0A5A9NZJ4.1
#=GS A0A3L8Q968_CHLGU/44-82    AC A0A3L8Q968.1
#=GS G5BAH6_HETGA/168-255      AC G5BAH6.1
#=GS A0A2Y9GFX2_NEOSC/168-255  AC A0A2Y9GFX2.1
#=GS A0A383YZK9_BALAS/169-256  AC A0A383YZK9.1
#=GS A0A673VHL9_SURSU/171-257  AC A0A673VHL9.1
#=GS A0A7F8PYX6_LEPWE/168-255  AC A0A7F8PYX6.1
#=GS A0A341DAB4_NEOAA/232-319  AC A0A341DAB4.1
#=GS A0A1A6G4T1_NEOLE/121-208  AC A0A1A6G4T1.1
#=GS L5LHN8_MYODS/162-249      AC L5LHN8.1
#=GS A0A3Q7MFH3_CALUR/115-202  AC A0A3Q7MFH3.1
#=GS A0A315VAD2_GAMAF/206-297  AC A0A315VAD2.1
#=GS A0A6J1V4J6_9SAUR/166-252  AC A0A6J1V4J6.1
#=GS A0A7F8Q1L2_LEPWE/112-199  AC A0A7F8Q1L2.1
#=GS A0A3Q0GVU8_ALLSI/60-145   AC A0A3Q0GVU8.1
#=GS A0A287DEN9_ICTTR/162-249  AC A0A287DEN9.1
#=GS A0A2R8QHQ6_DANRE/165-258  AC A0A2R8QHQ6.1
#=GS A0A2Y9P405_DELLE/232-319  AC A0A2Y9P405.1
#=GS A0A6P9BZZ0_PANGU/167-253  AC A0A6P9BZZ0.1
#=GS A0A2Y9DWR9_TRIMA/168-255  AC A0A2Y9DWR9.1
#=GS A0A1A6GNX2_NEOLE/157-244  AC A0A1A6GNX2.1
#=GS A0A096LWR2_POEFO/164-257  AC A0A096LWR2.1
#=GS L8IM63_9CETA/169-256      AC L8IM63.1
#=GS A0A2Y9EZU1_PHYMC/169-256  AC A0A2Y9EZU1.1
#=GS A0A6P7NR43_BETSP/159-253  AC A0A6P7NR43.1
#=GS A0A6P5LLE5_PHACI/176-241  AC A0A6P5LLE5.1
#=GS A0A6J3HAJ3_SAPAP/168-255  AC A0A6J3HAJ3.1
#=GS A0A6P5LLE5_PHACI/251-310  AC A0A6P5LLE5.1
#=GS F7H859_CALJA/168-255      AC F7H859.2
#=GS H2QGS4_PANTR/168-255      AC H2QGS4.1
#=GS A0A2U4APA9_TURTR/133-220  AC A0A2U4APA9.1
#=GS G1P6T7_MYOLU/171-258      AC G1P6T7.1
#=GS A0A341DAC0_NEOAA/156-243  AC A0A341DAC0.1
#=GS A0A673V5Q9_SURSU/168-255  AC A0A673V5Q9.1
#=GS A0A6I9LU07_PERMB/168-255  AC A0A6I9LU07.1
#=GS A0A498MAL9_LABRO/133-183  AC A0A498MAL9.1
#=GS A0A6J1Z2C3_ACIJB/81-168   AC A0A6J1Z2C3.1
#=GS A0A4W6C8K3_LATCA/159-254  AC A0A4W6C8K3.1
A0A5F5XCI6_FELCA/164-251             ................RQINVHETEDLILDCELDWHKLSQGLTYYSF........YRVWGS....NSE.TLVSEGKRPTLIKRLVRPEDAGNYRCELGTE.RSGPATVIHFEVTVLPK.........................
A0A2R9A1Y2_PANPA/168-255             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK.........................
A0A2U3WZY4_ODORO/168-255             ...............r-PVIVHEMEDLILNCELNWHRLSQGLTDYNF........FRVWGR....DSE.TLLYKGKNPTLIKTAVTAEDAGVYRCSLDSV.RSIPATIILYEVKVLPK.........................
A0A2Y9PE52_DELLE/232-319             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A6P7NPL2_BETSP/159-253             ..............yp--VQAEEGGQAVLNCFVPWHRLLVGKSEYHYswapgvpgTKKLNQ....SDF.RPLVVTDDSSVILNQLHVDEQGTYRCSLRE-.NETVFYQVTFSVTVSP-l........................
A0A6J3ATE0_VICPA/133-220             ................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWQN....NSE.TLMSKGIQPTLTKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK.........................
A0A455ATP9_PHYMC/71-158              ................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK.........................
V8PHR1_OPHHA/159-245                 ................RKVHVEIDEDLILDCALKWHKASHGVKTYRF........YRMVNN....K-E.KLMASGADSFLTKKEVNMKDAGRYRCKMVDT.KGYTSSQLDFQVVVLP-p........................
A0A6P9BVY0_PANGU/131-217             ................RKVQVEMDEDLILDCALKWHKASHGVKTYRF........YRMVGN....K-E.KLMASGADSFLTKKEANMNDAGTYRCKMVDT.NGGTSSELDFQVVVLP-p........................
A0A674HR81_TAEGU/683-727             ................RQLWVEEGQDLVLDCALPWHGASHGAKTYSF........YRVSD-....---.-------------------------------.-----------------pspnsagtl................
A0A6J3AWG2_VICPA/144-231             ................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWQN....NSE.TLMSKGIQPTLTKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK.........................
A0A1S3G4U8_DIPOR/168-202             ...............h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YR----....---.-------------------------------.-----------------gp.......................
A0A6G1A8Y0_CROCR/168-251             ................RRISVYEKDDMNLDCQLDWHTIAEGVTNYSF........YRVWGS....NSE.TLMYQGKRPALAKPLVRREDAGNYRCELGTE.RSGPVSIIRFEVT----.........................
G1TVX5_RABIT/168-255                 .............hrs---EVHQMDDLILDCKLSWHQASQGLTDYSF........YRVWGN....NSE.TLMAKGKAHLLTKPLVGPEDAGTYRCELGTV.SSGPATIMRFQVTVLP-p........................
A0A4U1FTS2_MONMO/225-312             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A5F8GFN4_MONDO/205-293             ................QAVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTN....GTE.VLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD.........................
A0A671EGI0_RHIFE/168-255             ................RKVKVHEMEDMILDCELNWHHASQGLTDYSF........YRVWRN....KSE.TLVSKGKEPTLTKIMVDPLDAGTYRCQLDTV.QSSPATVIRFHVTVLPK.........................
A0A6P8SUL3_GEOSA/161-247             ...............r-SLSVVEDEDLILDCALVWHLKMELFKDYAF........YKVVSG....K-K.VMLSVGTDAILVIKGVALQDAGQYQCDANDS.SGNPFSTIMYIVKV---dka......................
A0A673VGM3_SURSU/168-255             ................RHVNVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....NSE.TLVYEGKQPTLTKLLVSPEDAGTYRCELGTV.RSGPATIIHFQVTVLPQ.........................
A0A2I4AR79_9TELE/133-226             ...............p--VEAEEGGQAVLNCFVSWHRLLLGNPEYYYswa.petgNKELDE....KDF.TALVVTEDSFVVLNQLHLDEQGTYQCSLRDQ.NGTVFYRVTFLLSVAP-l........................
IZUM1_HUMAN/168-255                  ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK.........................
#=GR IZUM1_HUMAN/168-255       SS    ................EEEEEETTS-EEEE---GGGGGSCSEEEEEE........EEE-TT....S-E.EEEEEES-SEEEESS--GGG-EEEEEEEEES.SSSESEEEEEEEEEEST.........................
A0A6I9MKP5_9TELE/160-255             ..............yp--VQAEEGGQAVLNCFLPWHRILLEKTEYHYswapgvpgTKKLNE....SDF.KALVVTDDSSVVLNQLHVAEQGTYRCSLQGR.NGTVFYRVTFLLTVAP-v........................
A0A5F8GDG0_MONDO/205-293             ................QAVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTN....GTE.VLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD.........................
A0A340XT57_LIPVE/169-256             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATVIYFHVTVLPK.........................
A0A341DAW5_NEOAA/169-256             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A2Y9P400_DELLE/225-312             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A6P5LSV0_PHACI/222-281             .............gwg-------------------------------........-QVWPN....GSE.ILVSQSQESTLTKPMVSLEDSGVYRCILGTIrEHSPATVITYHVKV---dqe......................
A0A455AUE3_PHYMC/169-244             ................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YR----....---.-----GKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK.........................
A0A3P4PZV3_GULGU/168-255             ...............r-VVLVHEKEDMILNCELNWHRLSQGLTDYSF........FRVWGQ....NSE.TLLSEGKDPILTKTAVTAEDAGVYRCRLGTV.QAIPATVLLFRVTVLPE.........................
G3QFY5_GORGO/168-255                 ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVRVLPK.........................
A0A6G1A9N2_CROCR/172-259             ................RQINVHEKEDMILDCELNWHKFSQGLTNYSF........YRVWGS....NSE.TLLYKGGRPTLTQRLVMPEDAGNYRCELGTV.RSGPATVIHFQVTVLPE.........................
A0A4D9DSM3_9SAUR/146-232             ................RRLRVQQDDDLILDCALTWHRASYGAKSYRF........YRAAGG....-SE.QVMVMGPDAFLVKKEATANDSGRYRCEMLNA.QGWVCSELRFQVTVTP-l........................
A0A383YZJ7_BALAS/115-202             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....HSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A3Q7TIP7_VULVU/166-252             ...............h-EVVVHELEDLVLDCELSWHRISAGVNNYTF........YRVLGS....NS-.LLLSVGKEPTLTKTMVRLEDAGTYRCELANM.KTSRAGVTHFHVRVLPQ.........................
A0A2K5MSM3_CERAT/168-255             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPILTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK.........................
A0A6J2UNE1_CHACN/165-258             ...............h-HLEAEEGDQVVLDCFLPWHTLVMGQPDYHYswr..pltQNLSIE....GDY.KVLVVTPESKIVLNQLRVEEQGVYRCLLQDS.EGTTLSRTHFILTVNP-l........................
A0A2Y9PE60_DELLE/169-256             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A6G1AAR5_CROCR/168-255             ................RQINVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....DSE.TLVYKGKQPTLTKPLVRPEDAGNYRCELGTV.QSGPATIIHFQVTVLPQ.........................
A0A673V712_SURSU/168-255             ................RQVNVHEKEDMILDCELNWHKFSQGLTNYSF........YRVWGS....NSE.TLVYKGRRPTLTKPLVGPEDAGTYRCELGTV.RSGPATIIHFQVTVLPQ.........................
A0A6I9K3Q9_CHRAS/168-255             ................RHIEVHQMEDMILDCELNWHRSSQGLTDYKF........YRVWEN....KTE.TLVSKGKQPTLAKSMVSPEDEGKYRCELGTV.NDSPATIIYFRVKVLPK.........................
IZUM1_MOUSE/168-255                  ................RHIEVHRSEDLVLDCLLSWHRASKGLTDYSF........YRVWEN....SSE.TLIAKGKEPYLTKSMVGPEDAGNYRCVLDTI.NQGHATVIRYDVTVLP-p........................
#=GR IZUM1_MOUSE/168-255       SS    ................EEEEEETTS-EEEE---GGGGT-SSEEEEEE........EEE-TT....S-E.EEEEEES-SEEEE-S--GGG-EEEEEEEEES.SS-EEEEEEEEEEEE---........................
A0A6J0U8M1_9SAUR/166-252             ................RRVQVEMDEDLILDCALTWHKASHGVKRYNF........FRVVNG....EQK.-MMASSTDSFLIKKEANINDTGRYRCEMLDP.KGHPASQLDFQVVVLP-s........................
A0A6J3QIW9_TURTR/162-249             ................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A5F5Y579_FELCA/152-239             ................RQINVHETEDLVLDCELDWHKLSEGLTNYSF........YRVWGS....NSE.TLVYKGKRPTLTKPLVGPEDAGTYRCELGTE.RHGPSTIIHFEVTVLPQ.........................
A0A6P6BLH4_PTEVA/168-255             ................REVTVHAMEDMILDCELNWHHASEGLTDYSF........FRVWTN....KSE.TLVSKGKEPTLTKTMVDSKDAGTYRCQLDTV.QSSPATIIYFNVSVLPK.........................
A0A3Q0GZH2_ALLSI/57-142              ................RKLEVEEDEDLILDCALTWHHVSYGIKNYIF........YRVWGH....TEQ.-HIVSGPDPFLVRKEVTVNDSGSYRCEMRDA.KNMLCSQMQFQVT----geg......................
A0A7N6AM00_ANATE/159-253             ..............yp--VQAEEGGQAVLNCFLPWHRLLLGKPEYHYswaagvpgTKKLNE....SDF.KPLVVTDDSSVILNQLHVDEQGTYRCSLQG-.NGTVFYQVTFFLTVNP-l........................
A0A6P8VNK4_GYMAC/160-255             ..............yp--VQAEEGGQAVLNCFLPWHRILLEKTEYHYswapgvpgTKKLNE....SDF.KALVVTDDSSVVLNQLHVAEQGTYRCSLQGR.NGTIFYRVTFLLTVAP-v........................
H3DD44_TETNG/56-151                  ................NTVQAEEGGQAVLDCLQPWHHLLMGRPEYHFswapgvpgTKTVNE....SNF.IVLVVTEDSSLVLNQLRLDEQGTYRCSLQDQ.NETVFYQVHFLLTVAP-l........................
A0A287BMD8_PIG/169-256               ................RKVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWKN....NSE.TLMAKGQEPTLTKTMVSPKDAGTYRCELGTV.QSTPATIIHFHVTVLPK.........................
A0A553QS85_9TELE/165-258             .............qyl---AADEGEEVLLDCLLPWHSLVAGQTEYHYswh..pgeINLTEE....VEY.EELVVTKDSKIVLNQLRVSEGGTYRCLLMDQ.KGTEVSRMHFILKVNP-f........................
A0A6J2QBP9_COTGO/159-254             ..............yp--VQAEEGGQAVLNCFLPWHRLLLGRPEYHYswapgvpgTKNLSE....SDF.KALVVTDDPSVVLNQLHEDEQGTYRCSLQGR.NGTVFYRVTFLLTVA--tl.......................
A0A673V6R6_SURSU/168-254             ................RQVNVHEKEDMILDCELNWHKFSQGLTNYSF........YRVWGS....NSE.TLVYSGRRPTLTKPLVGPEDAGNYRCELGTV.RSGPATIIHFQVTG---qc.......................
G3HZX1_CRIGR/395-482                 ................RRIEVHRMEDMVLDCQLSWHHASEGLTEYSF........YKVWGN....SSE.TLMSKGREPYMTKTMVGPEDAGNYRCELGTI.NAGPATIIHFRVIVL--ga.......................
A0A384BKU3_URSMA/168-255             ................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....KAE.TLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVRGL--ll.......................
A0A6J1Z0K8_ACIJB/1-55                ................-------------------------------........--VWGS....NSE.TLVYKGKQPTLTKPLVGPEDAGDYRCELGTV.RSLPATVIHFKVTVLPQ.........................
E2RRM5_CANLF/1-34                    ................-------------------------------........------....---.--------------MVRLEDAGTYRCELANM.KTSRAAVTHFRVRVLPQ.........................
A0A6P7J2G5_9TELE/160-255             ..............yp--VHAEEGGQAVLNCFLPWHRLLLGRPEYHYswapgvpgTEKVNE....SDF.KALVVTGDSSVVLNQLHVDEQGTYRCSLQDQ.NGAIYYQATFLLTVTP-l........................
A0A2K6SYH0_SAIBB/168-255             ................RNVEVPHMEDMILDCELNWHKASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKPVVGPEDAGDYRCELGTV.NSSPATIILFHVTVLPK.........................
A0A3Q2KUM8_HORSE/168-255             ................RQVKVHRKEDMILDCELNWHRASEGLTDYSF........YRVWGK....NDE.TLVSKGKEPTLTKTMVGPEDQGTYRCELGTV.QSDPATIIYFHVTVLPQ.........................
A0A6P6MTI4_CARAU/189-282             ...............h-HLEADEGEEVVLDCFLPWHALIVGQTEYHYswh..pgeKNLSQD....GEY.EVLVVTEESKIVLNQLKVNEEGTYRCLLQDQ.KDTALSRMYFKLKVNP-l........................
A0A287CWI4_ICTTR/169-256             .............rve---EIHEHEALNLNCFLDWHKEAVGLTNYVF........YRVWEN....NSE.TVLYSGKDPVFNRPSASVNDSGKYRCELGTI.YNRPSTIIHFLVTVLPR.........................
A0A6P9C876_PANGU/156-242             ................RKVQVEMDEDLILDCALKWHKASHGVKTYRF........YRMVGN....K-E.KLMASGADSFLTKKEANMNDAGTYRCKMVDT.NGGTSSELDFQVVVLP-p........................
A0A6J1XMY2_ACIJB/168-208             ................RQINVHEKEDLVLDCELNWHKLSQGLTYYSF........YRV---....---.-------------------------------.-----------------gpstpst..................
A0A673VGQ4_SURSU/168-255             ................RHVNVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....NSE.TLVYEGKQPTLTKLLVSPEDAGTYRCELGTV.RSGPATIIHFQVTVLPQ.........................
A0A6P5LLE6_PHACI/176-264             ...............q-SVRVTENDDLVLDCELSWHKAAEGLTDYRF........YRVWPN....GSE.ILVSQSQESTLTKPMVSLEDSGVYRCILGTIrEHSPATVITYHVKV---dqe......................
A0A673VH43_SURSU/145-231             ................RHVNVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....NSE.TLVYEGKQPTLTKLLVSPEDAGTYRCELGTV.RSGPATIIHFQVTG---qc.......................
A0A2Y9P6M3_DELLE/134-221             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A6J0X3U2_ODOVR/169-256             ................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.KSSPATIIYFHVTVLPK.........................
A0A5J5MUG0_MUNRE/202-289             ................REVNVHQMEDMMLDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.KSSPATIIYFHVTVLPK.........................
A0A6G1A966_CROCR/173-256             ................RQINVRELDNMILDCELDWHTIAEGVTNYSF........YRVWGS....NSE.TLMYKGKQPAVIKRMMMPVDAGNYRCELGTE.RSGPVSIIRFEVT----.........................
A0A2U4APR3_TURTR/169-244             ................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YR----....---.-----GKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
C6ZEA2_CAPHI/169-256                 ................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSRGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK.........................
A0A455AS83_PHYMC/232-319             ................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK.........................
A0A091D708_FUKDA/184-271             ................RSVEVHQMEDMILDCHLNWHQASQGLTDYSF........YRVWGN....NSE.TLVSKGKESLLTKPLVGPEDAGDYLCELGTV.SYGPATIINFHVTVLPE.........................
A0A452C6X0_BALAS/71-158              ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....HSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A6P7NPS1_BETSP/135-229             ..............yp--VQAEEGGQAVLNCFVPWHRLLVGKSEYHYswapgvpgTKKLNQ....SDF.RPLVVTDDSSVILNQLHVDEQGTYRCSLRE-.NETVFYQVTFSVTVSP-l........................
A0A452R3V2_URSAM/168-255             ................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....KAE.TLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVRGL--ll.......................
A0A3B1K9P2_ASTMX/111-192             ..............he--LKGQEGEQVVLDCFLSWHSLIIGQAEYHYs......wKRGARN....ELF.EVLVVTEESKIVLNQLSVSEQGVYRCLLLDK.H----------------gtelsrmi.................
A0A5F5Y1D5_FELCA/152-239             ................RQINVHETEDLVLDCELDWHKLSEGLTNYSF........YRVWGS....NSE.TLVYKGKRPTLTKPLVGPEDAGTYRCELGTE.RHGPSTIIHFEVTVLPQ.........................
A0A2Y9P6L9_DELLE/232-307             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YR----....---.-----GKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A6J1XMR2_ACIJB/161-201             ................RQINVHEKEDLVLDCELNWHKLSQGLTYYSF........YRV---....---.-------------------------------.-----------------gpstpst..................
A0A6J0X0P0_ODOVR/169-233             ................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDA----------.-----------------vlpk.....................
A0A5F5XDM7_FELCA/156-235             ................RQINVHETEDLVLDCELDWHKIATGATGYSF........YRVWGS....KAD.SLLYTGKWPTLTKQLVRPADAGTYRCALGTP.GS---------------aaivtqp..................
A0A2U4APB7_TURTR/169-256             ................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A2K5DEP7_AOTNA/168-255             ................RDVEVPRMEDMILDCELNWHKASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKPMVGPEDAGDYRCELDTV.NSSPATIILFHVTVLPK.........................
A0A5F8GJG2_MONDO/205-293             ................QAVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTN....GTE.VLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD.........................
A0A6J1XMV9_ACIJB/136-176             ................RQINVHEKEDLVLDCELNWHKLSQGLTYYSF........YRV---....---.-------------------------------.-----------------gpstpst..................
A0A1S3AJR4_ERIEU/169-256             ................REIQVHAMEDLILDCELNWHQASQGLTDYSF........YRVWQN....NTK.TLVSRGKESTLSKPMVDPKDAGTYLCELGTV.QSSPATIIHFHVKVLPK.........................
A0A673V750_SURSU/169-256             ................RQVNVHEKEDMILDCELNWHKLSQGLTSYSF........YRVWGS....NSE.TLVYKGRRPTLTKPLVGPEDAGTYRCELGTV.RSGPATIIHFQVTVLPQ.........................
A0A3Q7TNL9_URSAR/143-230             ................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....KAE.TLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVRGL--ll.......................
H0WN21_OTOGA/168-255                 ................RNVEVHEMEDMILDCELSWHRMSQGLSNYRF........YRVWGN....KSE.TLVSDGKEPTLTKPMVGAEDAGNYRCELGLV.KSSPATIIHFHVTVLPK.........................
A0A6J3AXH3_VICPA/162-249             ................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWQN....NSE.TLMSKGIQPTLTKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK.........................
A0A5N5NM21_PANHP/166-242             ...............h-QVLANVGEQAVLDCFLPWHSLFS-------........----AE....DRF.EVLVVTKDSKIVLNQLSVSEQGVYRCFLLDQ.HGTTLSHTLFILTVIP-m........................
G3TPD8_LOXAF/168-255                 ................RQVEVQQMEDMILDCELNWHRASQGLTDYSF........YRVWEN....KTE.TLVSKGKEPTLAKPMVGPEDAGTYRCELGTV.KKSPATIIHFRVKVLPR.........................
A0A2U4APA6_TURTR/162-249             ................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A212DBK5_CEREH/162-249             ................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.KSSPATIIYFHVTVLPK.........................
A0A341DDB0_NEOAA/169-256             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
M7B083_CHEMY/23-89                   rcgaclipvslrqvvg-------------------------------........------....GVE.QVIVTGPDAFLVKKEATVNDSGHYRCEMLNA.QGWVCSKLRFQVTVTP-l........................
A0A2U4APB1_TURTR/169-256             ................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A1S3NNR7_SALSA/185-280             ..............yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTE....GDF.RVLVVTEDSSVVLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s........................
A0A1S3NNQ8_SALSA/160-255             ..............yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTE....GDF.RVLVVTEDSSVVLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s........................
A0A5E4BCK9_MARMO/170-256             ...............r-LVKVHEKENLTLNCLFEWHPLSVGLTDYQF........YRITED....GSE.KLLYKGKNPMLTIPSVNPDNSGSYRCELGSV.SSGPATIFHYLVT----eet......................
A0A6G1A9N1_CROCR/174-261             ................RQINVHEKEDMILDCELSWHKLSEGLTNYSF........YRVWGS....NSE.TLLYKGKRPTLTKPLVRPEDAGNYRCELGTV.RSSPATIIHFQVTVLPQ.........................
A0A2K6NEL4_RHIRO/168-255             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGRYRCELGSV.NSSPATVINFRVTVLPE.........................
A0A6P6H407_PUMCO/169-256             ................RQINVHEKEDLVLDCELDWHKIATGATGYSF........YRVWGS....KAD.SLLYMGKWPTLTKQLVRPADAGTYRCALGTP.GVSLFSAIRFEVTVLPR.........................
A0A2U4APC4_TURTR/169-256             ................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A2K6C510_MACNE/141-228             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK.........................
A0A0A0MU86_PAPAN/168-255             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK.........................
A0A7F8K902_DELLE/162-249             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A2Y9PC54_DELLE/232-318             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVT----gps......................
A0A6I9IF17_VICPA/169-256             ................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWQN....NSE.TLMSKGIQPTLTKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK.........................
A0A6J1Z0B5_ACIJB/48-135              ................RQINVHEKEDLVLDCELNWHKLSEGLTNYSF........YRVWGS....NSE.TLVYKGKRPTLTKPLVGPEDAGTYRCELGTE.RHGPSTIIHFEVTVLPQ.........................
H9H653_MONDO/198-286                 ................QAVQVIEKGDLILDCELSWHKKSEGLTDYSF........YKILTN....GTE.VLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD.........................
A0A6P6H306_PUMCO/60-147              ................RQINVHEKEDLLLDCELNWHKLSQGLTYYSF........YRVWGS....NSE.TLVYKGKQPTLTKPLVGPEDAGDYRCELGTV.RSLPATVIHFKVTVLPQ.........................
A0A6P5LS24_PHACI/149-214             ................QSVRVTENDDLVLDCELSWHKAAEGLTDYRF........YRVLPG....PMS.C------------------------------.-----------------lalgvnsrslglptplwipaglwsc
A0A6P6H2P4_PUMCO/55-142              ................RQINVHETEDLILDCELDWHKLSQGLTYYSF........YRVWGS....NSE.TLVSEGKRPTLIKRLVRPEDAGNYRCELGTE.RSGPATIIHFEVTVLPK.........................
A0A2U3YV44_LEPWE/168-255             ..............rl--VIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGK....DSE.TLLSKGKNSTLIKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g........................
A0A383YZJ5_BALAS/140-227             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....HSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
IZUM1_RAT/168-255                    ................RQIEVHRLEDMVLDCQLSWHHASEGLTDYSF........YRVWGN....SSE.TLMSKGKEPYLTKTMVGPEDAGNYRCELDTV.NAGPATIIYYHVTVLP-p........................
E1BDA8_BOVIN/169-256                 ................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK.........................
A0A6J2N838_9CHIR/168-255             ...............r-IIKVHEMEDMILDCELNWHQASQGLTDYNF........YRVWRN....KSE.TLVSKGKEPTLTKTMVAPKDAGTYRCQLDTV.KSSPATVIRFHVKVLPK.........................
A0A2K6FJK7_PROCO/168-255             ................RKVEVHQMEDMILDCELNWHHASEGLSYYRF........YRVWEN....NTE.TLVSMRTAPTLTKPMVGPKDAGRYRCELGSV.NSSPATIIYFNVTVLP-t........................
A0A6P7NJD8_BETSP/159-253             ..............yp--VQAEEGGQAVLNCFVPWHRLLVGKSEYHYswapgvpgTKKLNQ....SDF.RPLVVTDDSSVILNQLHVDEQGTYRCSLRE-.NETVFYQVTFSVTVSP-l........................
A0A484DCS2_PERFV/160-255             ...............p--VLAEEGGQAVLNCFLPWHRLLLERPEYHYswapgvpgTEKLIE....RDF.KALVVTDDSSVVLNQLHVDEQGTYRCSLLDQ.SGTVFYQVTFLLAV---shlp.....................
A0A6P7NJU8_BETSP/152-246             ..............yp--VQAEEGGQAVLNCFVPWHRLLVGKSEYHYswapgvpgTKKLNQ....SDF.RPLVVTDDSSVILNQLHVDEQGTYRCSLRE-.NETVFYQVTFSVTVSP-l........................
A0A2K5RHC0_CEBIM/141-228             ................RNVDVPHMEDMILDCELNWHKASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKPMVGPEDAGDYRCELGTV.NSSPATIIFFHVTVLPK.........................
A0A6J3AZC8_VICPA/169-256             ................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWQN....NSE.TLMSKGIQPTLTKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK.........................
A0A673VGC9_SURSU/168-254             ................RQVNVHEKEDMILDCELNWHKFSQGLTNYSF........YRVWGS....NSE.TLVYSGRRPTLTKPLVGPEDAGNYRCELGTV.RSGPATIIHFQVTG---qc.......................
A0A6J1XMP6_ACIJB/143-183             ................RQINVHEKEDLVLDCELNWHKLSQGLTYYSF........YRV---....---.-------------------------------.-----------------gpstpst..................
G1QXF7_NOMLE/168-255                 ................RNVEVPQMEDMMLDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPK.........................
A0A3Q7MFL5_CALUR/168-255             ...............r-PVIVHEMEDLILNCELNWHRLSQGLTDYNF........FRVWGR....DSE.TLLYKGKNPTLIKTAVTAEDAGVYRCSLDSV.RSIPATIILYEVKVLP-g........................
L5L4K5_PTEAL/134-221                 ................REVTVHAMEDMILDCELNWHHASEGLTDYSF........FRVWTN....KSE.TLVSKGKEPTLTKTMVDSKDAGTYRCQLDTV.QSSPATIIYFNVSVLPK.........................
A0A6A5FCN3_PERFL/160-254             ...............p--VLAEEGGQAVLNCFLPWHRLLLGRPEYHYswvpgvpaTEKLIE....RDF.KALVVTDDSSVVLNQLHVDEQGTYRCSLQDQ.SGTVFYQVTFLLAVC--hl.......................
A0A3N0YT51_ANAGA/158-251             ...............h-HLEADEGEEVVLDCFLPWHALVIGQTEYHYswy..peeKNLPHD....GEY.EVLVVTEESKIVLNQLTINEEGTYRCLLQDQ.KGTVLSRMYFKLKV---nqp......................
A0A060Y0K2_ONCMY/179-274             ..............yp--VQAAEGGQAVLDCFLPWHSLVVGRPDYHYtwapgtqrTANLTE....GDF.RVLVVTEDSSVVLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s........................
A0A7F8K6G4_DELLE/162-249             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A2F0BN51_ESCRO/28-111              ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....HSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVT----.........................
M3XLJ0_LATCH/158-247                 ................RNISVSEFDSLRLDCSEPWHFKVQNKGLFTFn......vDLAEAG....SPR.TYLFASESPYLVINGITLEHQGTYHCQLTDR.DGDIVSEKRFEVNV---hsv......................
A0A556UG91_BAGYA/176-245             ..fvflfsglcpnkcg-------------------------------........-RFSDD....DEF.ETLVVTKDSKIVLNQLSVREQGVYRCFLLGQ.HGITLSHIHFILTVTP-v........................
A0A4X2KXL7_VOMUR/207-295             ...............q-SVRVMENGDMVLDCELSWHKAAEGLTDYRF........YRVWPN....GSE.ILISRSQESTLIKPMVSLEDSGVYRCILGTVrEHSPATVITYYVKV---dqe......................
A0A6J1Z1H6_ACIJB/55-142              ................RQINVHEKEDLVLDCELNWHKLSEGLTNYSF........YRVWGS....NSE.TLVYKGKRPTLTKPLVGPEDAGTYRCELGTE.RHGPSTIIHFEVTVLPQ.........................
A0A6J0X3S4_ODOVR/162-249             ................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.KSSPATIIYFHVTVLPK.........................
A0A1S3G3S8_DIPOR/168-208             ...............h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YRVGSC....---.-------------------------------.-----------------nssk.....................
A0A3Q7UBR6_URSAR/168-255             ................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....KAE.TLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVRVLPR.........................
A0A2Y9PC44_DELLE/196-283             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A341DAW0_NEOAA/219-306             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A337SB10_FELCA/153-240             ................RHINVHEKEDLVLDCELHWHKLSQGLTYYSF........YRVWGS....NSE.TLVYKGKQPTLTKPLVGPEDAGDYRCELGTV.RSLPATVIHFKVTVLPQ.........................
A0A3Q7UQT5_VULVU/137-223             ...............h-EVVVHELEDLVLDCELSWHRISAGVNNYTF........YRVLGS....NS-.LLLSVGKEPTLTKTMVRLEDAGTYRCELANM.KTSRAGVTHFHVRVLPQ.........................
A0A5E4BAQ5_MARMO/128-198             ..kkkteecggeswtr-------------------------------........WGVWEN....DSE.TELYRGKDPVFNRPSASVNDSGRYRCELGTV.YNRPSTIIHFLVTVLPR.........................
S9YYW1_CAMFR/162-249                 ................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGIQPTLTKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK.........................
A0A2K5ICP7_COLAP/168-255             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK.........................
A0A2Y9P1F4_DELLE/232-319             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A2U4APC0_TURTR/27-114              ................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A0D9S2Z4_CHLSB/170-257             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK.........................
A0A674K1A9_TERCA/168-254             ................RRLRVQQDDDLILDCALTWHRASYGAKSYRF........YRAVGG....-SE.QVMVMGPDAFLVKKEATANDSGRYRCEMLNA.QGWVCSELRFQVTVTP-l........................
A0A1U7QS27_MESAU/168-255             ................RRIEVHRLEDLVLDCQLSWHHASEGLTDYSF........YRVWGN....SSE.TLLSKGKEPYMTKSMVGPEDAGNYRCELGTV.NAGPATIIHFRVIVLPQ.........................
A0A6I9MYB6_9TELE/160-255             ..............yp--VQAEEGGQAVLNCFLPWHRILLEKTEYHYswapgvpgTKKLNE....SDF.KALVVTDDSSVVLNQLHVAEQGTYRCSLQGR.NGTVFYRVTFLLTVAP-v........................
A0A6P5LNW2_PHACI/120-185             ................QSVRVTENDDLVLDCELSWHKAAEGLTDYRF........YRVLPG....PMS.C------------------------------.-----------------lalgvnsrslglptplwipaglwsc
A0A6J3AWG9_VICPA/108-195             ................RKVEVHQMEDMILDCELNWHKISQGLTDYSF........YRVWQN....NSE.TLMSKGIQPTLTKIMVSPEDAGIYRCELGSV.KSSPATIIHFRVTVLPK.........................
F6XH82_MACMU/168-255                 ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK.........................
L9J9G8_TUPCH/134-220                 ................RQVEVYEMEDLILDCELNWHHASQGLTEYSF........YRVWAN....DSE.TLVSRKKEPTLTKPMVGPEDEGNYRCELGTV.NSGPATIIYFHVT----gdi......................
A0A6I9MZ79_9TELE/132-227             ..............yp--VQAEEGGQAVLNCFLPWHRILLEKTEYHYswapgvpgTKKLNE....SDF.KALVVTDDSSVVLNQLHVAEQGTYRCSLQGR.NGTVFYRVTFLLTVAP-v........................
A0A6P3FGL4_OCTDE/168-255             ................RHVEVHQMEDMILDCHLNWHQASQGLTDYSF........YRVWGN....NSE.TLMSKGKEPLLTKPLVGPEDAGHYRCELETV.SSGPATIIHFHVIVWPK.........................
A0A6P5LNV6_PHACI/251-310             .............gwg-------------------------------........-QVWPN....GSE.ILVSQSQESTLTKPMVSLEDSGVYRCILGTIrEHSPATVITYHVKV---dqe......................
A0A6P9C7A7_PANGU/56-142              ................RKVQVEMDEDLILDCALKWHKASHGVKTYRF........YRMVGN....K-E.KLMASGADSFLTKKEANMNDAGTYRCKMVDT.NGGTSSELDFQVVVLP-p........................
A0A1S3NNW2_SALSA/125-220             ..............yp--VEAAEGGQAVLDCFLPWHSLVVGQPDYHYtwapgtqrTANLTE....GDF.RVLVVTEDSSVVLNQLHVDEEGMYRCLLTDG.KGTVLSRTHFLLTVTP-s........................
A0A5F5XN54_FELCA/163-249             ................RHINVHEKEDLVLDCELHWHKLSQGLTYYSF........YRVWGS....NSE.TLLYKGKRPTLTKPLVGPEDAGNYRCELGIE.RSGPATVIHFEVTG---qs.......................
A0A437CZN9_ORYJA/167-262             ..............tp--VQAEEGGQVVFSCYQPWHYLISGKPEYYYswapvvpgTKKLNE....SDF.VPLVVTHDSSVVLNQLQLDEQGTYRCSLQEE.NRTVFYQVTFLLTVTP-l........................
S7PYD7_MYOBR/162-249                 ................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKN....KPE.SMVYKGTAPTLTKTKATPSDAGTYRCQLNTV.NNSPATIIRYHVRVLPK.........................
A0A7F8Q173_LEPWE/141-228             ..............rl--VIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGK....DSE.TLLSKGKNSTLIKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g........................
A0A6P6MVD5_CARAU/165-258             ...............h-HLEADEGEEVVLDCFLPWHALIVGQTEYHYswh..pgeKNLSQD....GEY.EVLVVTEESKIVLNQLKVNEEGTYRCLLQDQ.KDTALSRMYFKLKVNP-l........................
A0A341DBA1_NEOAA/232-319             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A3Q0DGU8_CARSF/55-142              ................RRVKVHQMEDMILDCEFNWHRASEGLTDYSF........YRVWGN....HSE.TLVSKGKEPTLTKPMVGQEDAGSYRCELGTV.TSEPGLLFDPSLPVLP-k........................
A0A455ASF7_PHYMC/162-249             ................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK.........................
G1M882_AILME/161-248                 ................REITVHEMEDLRLNCELSWHRLSQGLASYNF........FRVWGT....KSE.TLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.SSGPATIIHYHVRGL--ll.......................
A0A6P5LS24_PHACI/224-283             .............gwg-------------------------------........-QVWPN....GSE.ILVSQSQESTLTKPMVSLEDSGVYRCILGTIrEHSPATVITYHVKV---dqe......................
A0A6P5LSV0_PHACI/147-212             ................QSVRVTENDDLVLDCELSWHKAAEGLTDYRF........YRVLPG....PMS.C------------------------------.-----------------lalgvnsrslglptplwipaglwsc
A0A4W2ILL7_BOBOX/169-256             ................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK.........................
A0A7F8PYY1_LEPWE/143-230             ..............rl--VIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGK....DSE.TLLSKGKNSTLIKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g........................
A0A5F8GMC9_MONDO/198-286             ................QAVQVIEKGDLILDCELSWHKKAEGLTTYSF........FKILTN....GTE.VLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD.........................
A0A6P9BWS1_PANGU/156-229             ................RKVQVEMDEDLILDCALKWHKASHGVKTYRF........YRMVGN....K-E.KLMASGADSFLTKKEANMNDAGTYRCKMVDT.N----------------gvl......................
A0A6P5LNV6_PHACI/176-241             ................QSVRVTENDDLVLDCELSWHKAAEGLTDYRF........YRVLPG....PMS.C------------------------------.-----------------lalgvnsrslglptplwipaglwsc
K7DZS4_MONDO/205-293                 ................QAVQVIEKGDLILDCELSWHKKSEGLTDYSF........YKILTN....GTE.VLLSRGKDSALTKPMVAFEDGGSYRCILDTIrKHSPATIIVYRVQVIPD.........................
A0A3Q1DAP6_AMPOC/159-254             ..............hp--VQAEEGGQAVLDCFLPWHRLLLGKPEYHYfwapgapgTETLDE....SDF.KALVVTDDSSVVLNQLRVDEQGTYRCSLQDR.NGTIFYQITFLLTVAP-l........................
A0A2Y9L336_ENHLU/282-369             ...............r-VVLVHEKEDMILNCELNWHRLSQGLTNYSF........FRVWGQ....NSE.TLLSEGKDPILTKTAVTAEDAGVYRCRLGTV.RSIPATILFFRVTVLPE.........................
A0A6P5DD34_BOSIN/169-256             ................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK.........................
A0A3Q7VIE1_URSAR/168-255             ................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....KAE.TLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVRGL--ll.......................
A0A2K5UGJ7_MACFA/201-288             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK.........................
W5PRD0_SHEEP/169-256                 ................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSRGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK.........................
A0A6P5LNW2_PHACI/195-254             .............gwg-------------------------------........-QVWPN....GSE.ILVSQSQESTLTKPMVSLEDSGVYRCILGTIrEHSPATVITYHVKV---dqe......................
A0A6P7J359_9TELE/130-225             ..............yp--VHAEEGGQAVLNCFLPWHRLLLGRPEYHYswapgvpgTEKVNE....SDF.KALVVTGDSSVVLNQLHVDEQGTYRCSLQDQ.NGAIYYQATFLLTVTP-l........................
A0A5F5XG39_FELCA/165-251             ................RQINVHETEDLILDCELDWHKLSQGLTYYSF........YRVWGS....NSE.TLVSEGKRPTLIKRLVRPEDAGNYRCELGTE.RSGPATVIHFEVTG---qs.......................
A0A2K6LQN1_RHIBE/168-255             ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGRYRCELGSV.NSSPATVINFRVTVLPE.........................
A0A6P8FUG8_CLUHA/193-286             ...............h-RVEAEEGDQVVLDCFLPWHSLLSGHTEYHYswr..pgvQNVTSE....DEF.QGLVVTSDSNIVLNQLEVGEQGVYLCLLQDK.NGTVFSRTHFTLTVLT-p........................
A0A2K5DEQ1_AOTNA/168-255             ................RDVEVPRMEDMILDCELNWHKASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKPMVGPEDAGDYRCELDTV.NSSPATIILFHVTVLPK.........................
A0A2Y9P1F7_DELLE/169-256             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A2K6ADS1_MANLE/168-255             ................RSVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKSMVGPEDAGSYRCELGSV.NSSPATVINFRVTVLPK.........................
A0A7N5P678_AILME/168-210             ................REITVHEMEDLRLNCELSWHRLSQGLASYNF........FRVGPS....---.-------------------------------.-----------------kswrdl...................
A0A383YZS1_BALAS/169-244             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YR----....---.-----GKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A6P7NR48_BETSP/129-223             ..............yp--VQAEEGGQAVLNCFVPWHRLLVGKSEYHYswapgvpgTKKLNQ....SDF.RPLVVTDDSSVILNQLHVDEQGTYRCSLRE-.NETVFYQVTFSVTVSP-l........................
A0A6P6H2T4_PUMCO/168-255             ................RQINVHEKEDLVLDCELNWHKLSEGLTNYSF........YRVWGS....NSE.TLVYKGKRPTLTKPLVGPEDAGTYRCELGTE.RHGPSTIIHFEVTVLPQ.........................
A0A3Q7MFG9_CALUR/168-255             ...............r-PVIVHEMEDLILNCELNWHRLSQGLTDYNF........FRVWGR....DSE.TLLYKGKNPTLIKTAVTAEDAGVYRCSLDSV.RSIPATIILYEVKVLP-g........................
A0A5F9C4A8_RABIT/168-255             .............hrs---EVHQMDDLILDCKLSWHQASQGLTDYSF........YRVWGN....NSE.TLMAKGKAHLLTKPLVGPEDAGTYRCELGTV.SSGPATIMRFQVTG---qcq......................
A0A6J0X5E9_ODOVR/169-256             ................REVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.KSSPATIIYFHVTVLPK.........................
A0A3Q7V496_URSAR/168-255             ................REVTVHEMEDLRLNCELSWHRLSQGLANYNF........FRVWGT....KAE.TLLYTGNDHTLTKPAVTAEDAGVYRCSLDTV.RSGPATIIHFHVRGL--ll.......................
A0A1S3G3D2_DIPOR/168-204             ...............h-SVKVHEMEDIILDCHLNWHHASQGLADYSF........YRA---....---.-------------------------------.-----------------svt......................
A0A5A9NZJ4_9TELE/164-256             ..............hh--LEADEGVGVVLDCFLPWHTLVVGQTEYYYsw....lpAKNLSH....KGEyEELVVTEDSKIVLNQLRVNEQGVYRCLLQDQ.KKTTLSRIYFYLKVNP-l........................
A0A3L8Q968_CHLGU/44-82               ................RQLWVEEGQDLVLDCALPWHGASHGAKTYSF........YRGL--....---.-------------------------------.-----------------aaag.....................
G5BAH6_HETGA/168-255                 ................RNVEVHEMEDMILDCHLNWHQASQGLTDYSF........YRVWGN....NSE.TLESKGKESLLTKPLVGPEDAGDYRCELGTV.SYGPATIIYFHVTVLPK.........................
A0A2Y9GFX2_NEOSC/168-255             ..............rl--VIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGK....DSE.TLLSKGKNSTLIKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g........................
A0A383YZK9_BALAS/169-256             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....HSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A673VHL9_SURSU/171-257             ................RQINVHEKEDMILDCELNWHKLSEGLTNYSF........YRVWGS....NSE.TLVYSGRRPTLTKPLVGPEDAGNYRCELGTV.RSGPATIIHFQVTG---qc.......................
A0A7F8PYX6_LEPWE/168-255             ..............rl--VIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGK....DSE.TLLSKGKNSTLIKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g........................
A0A341DAB4_NEOAA/232-319             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A1A6G4T1_NEOLE/121-208             ................RRIEVPQLEDTVLDCQLSWHHASEGLTDYSF........YRVWGN....SSE.TLLSKGKKPYLTKTRVGPEDAGNYRCELGTI.NSGPATIIHFRVIVLPQ.........................
L5LHN8_MYODS/162-249                 ................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKN....KSE.SMVYKGTAPTLTKARAKPSDAGTYRCQLNTV.KNSPATIIRYHVRVLPK.........................
A0A3Q7MFH3_CALUR/115-202             ...............r-PVIVHEMEDLILNCELNWHRLSQGLTDYNF........FRVWGR....DSE.TLLYKGKNPTLIKTAVTAEDAGVYRCSLDSV.RSIPATIILYEVKVLP-g........................
A0A315VAD2_GAMAF/206-297             ..............hl--VQAEEEGQAVLNCFLPWHRFLLGRPEYHY........SRAIGEpdaiKDF.QLLVVTQDASIVLNQLHLDEQGTYRCSLQDE.NGAVYYRASFLLTVEP-l........................
A0A6J1V4J6_9SAUR/166-252             ................RKVLVEMDEDLILDCALKWHKASHGVKTYMF........YKMVNN....KEE.-LMASGADSFLTKKEANMKDAGRYRCKMVDT.KGYTSSQLDFQVVVLP-p........................
A0A7F8Q1L2_LEPWE/112-199             ..............rl--VIVHEMEDLILNCELSWHRLSQGLTDYSF........FRVWGK....DSE.TLLSKGKNSTLIKTAVTAEDAGVYRCSLDSV.RSIPATIIFYQVKVLP-g........................
A0A3Q0GVU8_ALLSI/60-145              ................RKLEVEEDEDLILDCALTWHHVSYGIKNYIF........YRVWGH....TEQ.-HIVSGPDPFLVRKEVTVNDSGSYRCEMRDA.KNMLCSQMQFQVT----geg......................
A0A287DEN9_ICTTR/162-249             .............rve---EIHEHEALNLNCFLDWHKEAVGLTNYVF........YRVWEN....NSE.TVLYSGKDPVFNRPSASVNDSGKYRCELGTI.YNRPSTIIHFLVTVLPR.........................
A0A2R8QHQ6_DANRE/165-258             ...............h-HLEADEGEEVVLDCFLSWHTLVVGQTEYHYswh..pgeTNVLFD....GEY.EELVVTKESKIVLNQLSVSEEGSYRCLLKDQ.KGTALSRTFFQLEVKP-f........................
A0A2Y9P405_DELLE/232-319             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A6P9BZZ0_PANGU/167-253             ................RKVQVEMDEDLILDCALKWHKASHGVKTYRF........YRMVGN....K-E.KLMASGADSFLTKKEANMNDAGTYRCKMVDT.NGGTSSELDFQVVVLP-p........................
A0A2Y9DWR9_TRIMA/168-255             ................RQVEVQQMQDMILDCELNWHRASQGLTDYSF........YRVWEN....KTE.TLVSKGKDPILAKPMVGPEDAGTYRCELGTV.NNSPATIIHFHVKVLPK.........................
A0A1A6GNX2_NEOLE/157-244             ................RRVEVPQMEDMVLDCQLSWHHASEGLTDYSF........YRVWGN....SSE.TLLSKGKEPYMTKIMVSPEDAGNYRCELGTI.NSGPATIIHFRVIVLPK.........................
A0A096LWR2_POEFO/164-257             ..............hl--VQAEEGGQAVLNCFLPWHRFLLGKPEYHYsra..tdlYTQLTE....KDF.QPLVVTQDASIVLNQLHLDEQGTYRCSLQDE.NGAVYYRASFQLTVKP-l........................
L8IM63_9CETA/169-256                 ................REVKVHHMEDMILDCELNWHKISQGLTDYSF........YRVWKN....NSE.TLVSKGKEPILTKTMVRPKDAGTYRCELGSI.QSSPATIIYFHVTVLPK.........................
A0A2Y9EZU1_PHYMC/169-256             ................RQVKVHQMEDMILDCELNWHKVSQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.RSSPATIIYFHVTVLPK.........................
A0A6P7NR43_BETSP/159-253             ..............yp--VQAEEGGQAVLNCFVPWHRLLVGKSEYHYswapgvpgTKKLNQ....SDF.RPLVVTDDSSVILNQLHVDEQGTYRCSLRE-.NETVFYQVTFSVTVSP-l........................
A0A6P5LLE5_PHACI/176-241             ................QSVRVTENDDLVLDCELSWHKAAEGLTDYRF........YRVLPG....PMS.C------------------------------.-----------------lalgvnsrslglptplwipaglwsc
A0A6J3HAJ3_SAPAP/168-255             ................RNVEVPHMEDMILDCELNWHKASEGLTDYSF........YRVWGN....NTE.TLVSKGKEPTLTKPMVGPEDAGDYRCELGTV.NSSPATIILFHVTVLPK.........................
A0A6P5LLE5_PHACI/251-310             .............gwg-------------------------------........-QVWPN....GSE.ILVSQSQESTLTKPMVSLEDSGVYRCILGTIrEHSPATVITYHVKV---dqe......................
F7H859_CALJA/168-255                 ................RDVEVPHMEDMTLDCELNWHKASEGLTDYSF........YRVWGN....NTE.TLVSKGKESTLTKPMVGPEDAGDYRCELGTV.NSSPATIILFHVTVLPK.........................
H2QGS4_PANTR/168-255                 ................RNVEVPQMEDMILDCELNWHQASEGLTDYSF........YRVWGN....NTE.TLVSKGKEATLTKPMVGPEDAGSYRCELGSV.NSSPATIINFHVTVLPR.........................
A0A2U4APA9_TURTR/133-220             ................RKVKVHQMEDMILDCELNWHKLSQGLTDYSF........YRVWGK....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
G1P6T7_MYOLU/171-258                 ................RRVNVHEMEDMILDCELNWHHISEGLTDYTF........YRVWKN....KPE.SMVYKGTAPTLTKTKANPSDAGTYRCQLNTV.KNSPATIIRYHVRVLPK.........................
A0A341DAC0_NEOAA/156-243             ................RKVKVHQMEDMILDCELNWHKISQGLTDYSF........YRVWGN....NSE.TLMSKGKEPTLTKTMVRPKDAGTYRCELGSV.QSSPATIIYFHVTVLPK.........................
A0A673V5Q9_SURSU/168-255             ...............q-YVNVHEKEDMILDCELSWHKLSEGLTNYSF........YKVWGS....NSE.ALMYTGTRPTLIKPLVGPEDAGLYRCELGTV.RSGPATIIHFEVTVLPQ.........................
A0A6I9LU07_PERMB/168-255             ................RRIEVPRLEDMVLDCQLGWHHASEGLTDYSF........YRVWGN....SSE.TLLSKGKEPYLTKTMVGPEDAGNYRCELGTI.NSGPATVIRFRVVVLPQ.........................
A0A498MAL9_LABRO/133-183             ................RHVEADEGEEVVLDCFLPWHALVVGQTEYHY........S-----....---.-------------------------------.-----------------whpreknvhahrqtntfsa......
A0A6J1Z2C3_ACIJB/81-168              ................RHINVREKEDMILDCELNWHKLSQGLTYYSF........YRVWGS....NSE.TLLYKGKWPTLTKPLVRPEDAGDYRCELGIE.RSGPATVIHFEVTVLPQ.........................
A0A4W6C8K3_LATCA/159-254             ..............yp--VQAEEGGQAVLNCFLPWHRLLLGKPEYHYswapgvpgTKKLDE....SHF.KSLVVTEDSSVVLNQLHVDEQGTYRCSLQGQ.NGAVFYRATFLLTAM--ts.......................
#=GC SS_cons                         ................EEEEEETTS-EEEE---GGGGCSCSEEEEEE........EEE-TT....S-E.EEEEEES-SEEEESS--GGG-EEEEEEEEES.SSSECEEEEEEEEEEST-........................
#=GC seq_cons                        ................RpVpVcphEDhILDCELsWH+lSpGLT-YSF........YRVWss....soE.TLlspG+-soLTKshVpscDAGsYRCcLsol.puuPATlIhFcVTVLP..........................
//
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