GenomeNet

Database: Pfam
Entry: LIDHydrolase
LinkDB: LIDHydrolase
Original site: LIDHydrolase 
#=GF ID   LIDHydrolase
#=GF AC   PF10230.12
#=GF DE   Lipid-droplet associated hydrolase
#=GF PI   DUF2305;
#=GF AU   KOGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   KOGs (KOG3975)
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.00;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0028
#=GF RN   [1]
#=GF RM   21478430
#=GF RT   The putative Saccharomyces cerevisiae hydrolase Ldh1p is
#=GF RT   localized to lipid droplets.
#=GF RA   Thoms S, Debelyy MO, Connerth M, Daum G, Erdmann R;
#=GF RL   Eukaryot Cell. 2011;10:770-775.
#=GF RN   [2]
#=GF RM   21478434
#=GF RT   Involvement of the Saccharomyces cerevisiae hydrolase Ldh1p in
#=GF RT   lipid homeostasis.
#=GF RA   Debelyy MO, Thoms S, Connerth M, Daum G, Erdmann R;
#=GF RL   Eukaryot Cell. 2011;10:776-781.
#=GF RN   [3]
#=GF RM   24357060
#=GF RT   Novel lipid droplet-associated serine hydrolase regulates
#=GF RT   macrophage cholesterol  mobilization.
#=GF RA   Goo YH, Son SH, Kreienberg PB, Paul A;
#=GF RL   Arterioscler Thromb Vasc Biol. 2014;34:386-396.
#=GF DR   INTERPRO; IPR019363;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is conserved from plants to humans. The
#=GF CC   function is as a lipid-droplet hydrolase. Human LDAH plays a
#=GF CC   role in cholesterol homeostasis [3].
#=GF SQ   1910
#=GS A0A6P4B931_ZIZJJ/36-286     AC A0A6P4B931.1
#=GS R7YVP5_CONA1/22-128         AC R7YVP5.1
#=GS A0A2K1XC88_POPTR/65-259     AC A0A2K1XC88.1
#=GS A0A6J1I921_CUCMA/78-328     AC A0A6J1I921.1
#=GS A0A4W6BNS3_LATCA/54-120     AC A0A4W6BNS3.1
#=GS A0A3Q2HT06_HORSE/43-328     AC A0A3Q2HT06.1
#=GS A0A316U4Z2_9BASI/34-309     AC A0A316U4Z2.1
#=GS A0A132AAT9_SARSC/1-107      AC A0A132AAT9.1
#=GS A0A0J7NLV7_LASNI/31-290     AC A0A0J7NLV7.1
#=GS A0A1B8D5A8_9PEZI/25-245     AC A0A1B8D5A8.1
#=GS A0A4W6BPR2_LATCA/156-233    AC A0A4W6BPR2.1
#=GS A0A165JWE0_9BASI/44-305     AC A0A165JWE0.1
#=GS A0A0E0FZ33_ORYNI/112-350    AC A0A0E0FZ33.1
#=GS F6HKQ8_VITVI/69-319         AC F6HKQ8.1
#=GS A0A096N270_PAPAN/43-303     AC A0A096N270.1
#=GS A0A6J2WLD6_CHACN/32-259     AC A0A6J2WLD6.1
#=GS A0A6J2S107_COTGO/38-297     AC A0A6J2S107.1
#=GS A0A2T4A2P3_TRIHA/21-344     AC A0A2T4A2P3.1
#=GS A0A194PQ03_PAPXU/26-276     AC A0A194PQ03.1
#=GS A0A3Q3M928_9TELE/37-296     AC A0A3Q3M928.2
#=GS A0A094CDN5_9PEZI/22-313     AC A0A094CDN5.1
#=GS LDAH_RAT/43-303             AC Q5HZX7.1
#=GS A8PVH8_MALGO/23-248         AC A8PVH8.1
#=GS X6PED7_RETFI/98-220         AC X6PED7.1
#=GS A0A672I051_SALFA/31-243     AC A0A672I051.1
#=GS A0A5F5PLV8_HORSE/43-161     AC A0A5F5PLV8.1
#=GS A0A0K6FYC7_9AGAM/59-129     AC A0A0K6FYC7.1
#=GS M7BD41_CHEMY/2-69           AC M7BD41.1
#=GS A0A0N0NJR9_9EURO/28-386     AC A0A0N0NJR9.1
#=GS A0A3Q3WZN5_MOLML/1-177      AC A0A3Q3WZN5.1
#=GS T0R8J3_SAPDV/69-311         AC T0R8J3.1
#=GS A0A2U4C058_TURTR/43-171     AC A0A2U4C058.2
#=GS A0A1V8U7D7_9PEZI/1-166      AC A0A1V8U7D7.1
#=GS A0A663MML2_ATHCN/43-157     AC A0A663MML2.1
#=GS A0A2S4VS45_9BASI/80-418     AC A0A2S4VS45.1
#=GS A0A395T1F6_9HYPO/17-290     AC A0A395T1F6.1
#=GS A0A803JPM0_XENTR/94-351     AC A0A803JPM0.1
#=GS A0A179FL24_METCM/17-304     AC A0A179FL24.1
#=GS H6C7Y4_EXODN/174-506        AC H6C7Y4.1
#=GS A0A058Z3J9_FONAL/88-387     AC A0A058Z3J9.1
#=GS LDAH_DROME/28-286           AC Q9W0H3.1
#=GS M7UCE7_BOTF1/1-137          AC M7UCE7.1
#=GS A0A1D1VXU7_RAMVA/53-193     AC A0A1D1VXU7.1
#=GS A0A1S4ACQ7_TOBAC/65-123     AC A0A1S4ACQ7.1
#=GS A0A0U1M4P0_TALIS/21-312     AC A0A0U1M4P0.1
#=GS E9E6T1_METAQ/17-311         AC E9E6T1.1
#=GS A0A6I9LLY0_PERMB/43-303     AC A0A6I9LLY0.1
#=GS S7QM02_GLOTA/39-296         AC S7QM02.1
#=GS A0A3P7IMM5_STRVU/1-38       AC A0A3P7IMM5.1
#=GS A0A2X0MTT4_9BASI/53-319     AC A0A2X0MTT4.1
#=GS A0A2P5WAI7_GOSBA/70-111     AC A0A2P5WAI7.1
#=GS E1BNE1_BOVIN/43-303         AC E1BNE1.2
#=GS A0A1S3A6J4_ERIEU/1-173      AC A0A1S3A6J4.1
#=GS K1XE50_MARBU/22-316         AC K1XE50.1
#=GS A0A168MVP5_ABSGL/37-289     AC A0A168MVP5.1
#=GS A0A367JF60_RHIST/28-65      AC A0A367JF60.1
#=GS A0A164ZIN3_XYLHT/156-367    AC A0A164ZIN3.1
#=GS A0A3Q2V3F7_HAPBU/31-290     AC A0A3Q2V3F7.1
#=GS A0A559MCL1_9HELO/25-317     AC A0A559MCL1.1
#=GS A0A0C3FVM9_PILCF/49-301     AC A0A0C3FVM9.1
#=GS A0A232FEH3_9HYME/527-786    AC A0A232FEH3.1
#=GS A0A1L9WGH2_ASPA1/30-364     AC A0A1L9WGH2.1
#=GS A0A1Q3CIT0_CEPFO/1-38       AC A0A1Q3CIT0.1
#=GS A0A2K5RTV4_CEBIM/43-106     AC A0A2K5RTV4.1
#=GS A0A158PMB7_ANGCS/39-207     AC A0A158PMB7.1
#=GS A0A0R3PWH3_ANGCS/47-186     AC A0A0R3PWH3.1
#=GS A0A2K5YPQ2_MANLE/43-303     AC A0A2K5YPQ2.1
#=GS A0A6J0DKF5_PERMB/43-164     AC A0A6J0DKF5.1
#=GS G0VH64_NAUCC/26-301         AC G0VH64.1
#=GS A0A445FIW0_GLYSO/85-141     AC A0A445FIW0.1
#=GS A0A4U6XGH7_9PEZI/3-309      AC A0A4U6XGH7.1
#=GS A0A100IMV6_ASPNG/32-350     AC A0A100IMV6.1
#=GS A0A287MNX7_HORVV/65-243     AC A0A287MNX7.1
#=GS K2SH48_MACPH/45-283         AC K2SH48.1
#=GS A0A498MA02_LABRO/4206-4464  AC A0A498MA02.1
#=GS A0A164ZIN3_XYLHT/24-139     AC A0A164ZIN3.1
#=GS A0A3S2NUJ5_ORYJA/50-309     AC A0A3S2NUJ5.1
#=GS A0A178V9X6_ARATH/12-262     AC A0A178V9X6.1
#=GS A0A316V9R2_9BASI/37-333     AC A0A316V9R2.1
#=GS A0A3Q1INU3_ANATE/38-297     AC A0A3Q1INU3.1
#=GS A0A0D9P4P8_METAN/33-323     AC A0A0D9P4P8.1
#=GS A0A165UKW1_9APHY/47-299     AC A0A165UKW1.1
#=GS A0A6A1Q8F9_BALPH/43-170     AC A0A6A1Q8F9.1
#=GS A0A3Q3AUI1_CHICK/96-355     AC A0A3Q3AUI1.1
#=GS A0A2B7YBJ5_9EURO/29-357     AC A0A2B7YBJ5.1
#=GS A0A319DT34_ASPSB/30-321     AC A0A319DT34.1
#=GS A0A287MNZ0_HORVV/42-292     AC A0A287MNZ0.1
#=GS A0A0D2CNL1_9EURO/63-128     AC A0A0D2CNL1.1
#=GS A0A261CPU7_9PELO/68-335     AC A0A261CPU7.1
#=GS A0A4U0U342_9PEZI/189-304    AC A0A4U0U342.1
#=GS A0A484GGF3_SOUCH/43-94      AC A0A484GGF3.1
#=GS A0A0T6AX84_9SCAR/34-286     AC A0A0T6AX84.1
#=GS A0A154PRM8_DUFNO/31-289     AC A0A154PRM8.1
#=GS A0A0R3RDP0_9BILA/2-203      AC A0A0R3RDP0.1
#=GS A0A2P6RCC6_ROSCH/41-81      AC A0A2P6RCC6.1
#=GS A0A6P5Z789_DURZI/33-281     AC A0A6P5Z789.1
#=GS A0A453GR31_AEGTS/92-129     AC A0A453GR31.1
#=GS A0A093NGQ7_PYGAD/43-302     AC A0A093NGQ7.1
#=GS A0A3Q7TM32_VULVU/43-303     AC A0A3Q7TM32.1
#=GS A0A2U3WB05_ODORO/43-303     AC A0A2U3WB05.1
#=GS B7FRS5_PHATC/115-213        AC B7FRS5.1
#=GS A0A0H2S913_9AGAM/54-306     AC A0A0H2S913.1
#=GS K7HBI6_CAEJA/41-326         AC K7HBI6.1
#=GS A0A4U0XHL5_9PEZI/19-366     AC A0A4U0XHL5.1
#=GS Q0UFS1_PHANO/25-334         AC Q0UFS1.1
#=GS A0A0D1CIJ0_USTMA/31-307     AC A0A0D1CIJ0.1
#=GS A0A0C2GDK2_9BILA/43-137     AC A0A0C2GDK2.1
#=GS A0A1Y2BD88_9TREE/53-311     AC A0A1Y2BD88.1
#=GS A0A4P6XL34_9ASCO/24-315     AC A0A4P6XL34.1
#=GS A0A6J1SX56_FRAOC/34-290     AC A0A6J1SX56.1
#=GS A0A6P5IWY2_PHACI/41-305     AC A0A6P5IWY2.1
#=GS A0A6J0DKJ5_PERMB/149-197    AC A0A6J0DKJ5.1
#=GS A0A1J1J9S7_9DIPT/56-313     AC A0A1J1J9S7.1
#=GS A0A317X388_9EURO/32-330     AC A0A317X388.1
#=GS A0A1V6UPM0_9EURO/27-324     AC A0A1V6UPM0.1
#=GS A0A165Y7G6_9AGAM/54-305     AC A0A165Y7G6.1
#=GS B4LG72_DROVI/29-291         AC B4LG72.1
#=GS Q6C1F7_YARLI/10-290         AC Q6C1F7.1
#=GS A0A4Q4V489_9PEZI/23-343     AC A0A4Q4V489.1
#=GS A0A370TYK2_9HELO/38-337     AC A0A370TYK2.1
#=GS A0A1M8A0W6_MALS4/27-316     AC A0A1M8A0W6.1
#=GS A0A1D5QFH1_MACMU/43-164     AC A0A1D5QFH1.1
#=GS A0A6P6SL76_COFAR/1-82       AC A0A6P6SL76.1
#=GS A0A5M3MQX2_CONPW/39-353     AC A0A5M3MQX2.1
#=GS A0A081CJB9_PSEA2/34-305     AC A0A081CJB9.1
#=GS A0A2K5IHX1_COLAP/43-162     AC A0A2K5IHX1.1
#=GS A0A2V1AR35_9ASCO/25-317     AC A0A2V1AR35.1
#=GS A0A2I3FV69_NOMLE/43-163     AC A0A2I3FV69.1
#=GS A0A444UMP4_ACIRT/57-316     AC A0A444UMP4.1
#=GS A0A1S3EXR0_DIPOR/43-303     AC A0A1S3EXR0.1
#=GS E9CU01_COCPS/134-454        AC E9CU01.1
#=GS A0A135LM14_PENPA/20-302     AC A0A135LM14.1
#=GS A0A485PRB0_LYNPA/43-303     AC A0A485PRB0.1
#=GS A8Y1R7_CAEBR/20-290         AC A8Y1R7.1
#=GS A0A446QGD0_TRITD/1-160      AC A0A446QGD0.1
#=GS V2Z273_MONRO/50-296         AC V2Z273.1
#=GS A0A091K7Z1_COLST/43-262     AC A0A091K7Z1.1
#=GS A4S8S1_OSTLU/88-341         AC A4S8S1.1
#=GS A0A2I2YKB9_GORGO/43-100     AC A0A2I2YKB9.1
#=GS A0A4S8ILI5_MUSBA/181-380    AC A0A4S8ILI5.1
#=GS A0A498IHD9_MALDO/60-295     AC A0A498IHD9.1
#=GS A0A1U7SEX4_ALLSI/43-302     AC A0A1U7SEX4.2
#=GS A0A7M7STC8_STRPU/86-343     AC A0A7M7STC8.1
#=GS A0A136J5W9_9PEZI/63-433     AC A0A136J5W9.1
#=GS A0A540LLC5_MALBA/40-85      AC A0A540LLC5.1
#=GS A0A1J9RT03_9PEZI/194-457    AC A0A1J9RT03.1
#=GS A0A671EBJ6_RHIFE/43-303     AC A0A671EBJ6.1
#=GS G5A9R9_PHYSP/112-357        AC G5A9R9.1
#=GS A0A7M7G6V7_NASVI/31-289     AC A0A7M7G6V7.1
#=GS A0A0D7AZC1_9AGAR/47-291     AC A0A0D7AZC1.1
#=GS A0A2P6RCC5_ROSCH/2-226      AC A0A2P6RCC5.1
#=GS A0A4Q4WHN8_9PEZI/23-346     AC A0A4Q4WHN8.1
#=GS A0A517L3G1_9PEZI/20-323     AC A0A517L3G1.1
#=GS C5GXQ5_AJEDR/172-418        AC C5GXQ5.2
#=GS A0A662Y2H7_9STRA/113-358    AC A0A662Y2H7.1
#=GS A0A2K5RTV0_CEBIM/43-163     AC A0A2K5RTV0.1
#=GS A0A0E0FZ31_ORYNI/130-368    AC A0A0E0FZ31.1
#=GS A0A3M7QMR0_BRAPC/34-299     AC A0A3M7QMR0.1
#=GS A0A267GVI3_9PLAT/34-289     AC A0A267GVI3.1
#=GS W9WXA0_9EURO/180-499        AC W9WXA0.1
#=GS A0A317CIV7_9GAMM/44-255     AC A0A317CIV7.1
#=GS D8UAJ7_VOLCA/33-300         AC D8UAJ7.1
#=GS A0A1Y2HA46_9FUNG/64-326     AC A0A1Y2HA46.1
#=GS A0A423VN37_9PEZI/19-323     AC A0A423VN37.1
#=GS A0A673VG22_SURSU/35-255     AC A0A673VG22.1
#=GS K0R7D0_THAOC/36-320         AC K0R7D0.1
#=GS Q2U7V0_ASPOR/1-290          AC Q2U7V0.1
#=GS A0A446P5J3_TRITD/1-160      AC A0A446P5J3.1
#=GS A0A287MNX2_HORVV/2-209      AC A0A287MNX2.1
#=GS A0A1W2P7C8_MOUSE/43-272     AC A0A1W2P7C8.1
#=GS A0A094C199_9PEZI/83-240     AC A0A094C199.1
#=GS A0A1L7WP28_9HELO/27-316     AC A0A1L7WP28.1
#=GS A0A6I9MPV6_9TELE/38-285     AC A0A6I9MPV6.1
#=GS A0A1D6G442_MAIZE/63-313     AC A0A1D6G442.1
#=GS A0A2T4BSI4_TRILO/21-355     AC A0A2T4BSI4.1
#=GS A0A1S8W4I9_9FUNG/90-322     AC A0A1S8W4I9.1
#=GS A0A078J2V0_BRANA/37-287     AC A0A078J2V0.1
#=GS A0A1X2I6Z7_9FUNG/38-293     AC A0A1X2I6Z7.1
#=GS V4T1F8_CITCL/89-354         AC V4T1F8.1
#=GS A0A167DXU4_9PEZI/3-296      AC A0A167DXU4.1
#=GS H9J299_BOMMO/1-223          AC H9J299.1
#=GS A0A2T3A983_9PEZI/21-349     AC A0A2T3A983.1
#=GS M9MIW2_PSEA3/34-306         AC M9MIW2.1
#=GS A0A316ZE41_9BASI/48-193     AC A0A316ZE41.1
#=GS A0A674IKU3_TERCA/56-315     AC A0A674IKU3.1
#=GS A0A0G2GBT3_9EURO/26-85      AC A0A0G2GBT3.1
#=GS N1RQ08_FUSC4/17-290         AC N1RQ08.1
#=GS A0A1W2TVV5_ROSNE/18-313     AC A0A1W2TVV5.1
#=GS A0A3M2T1E2_9EURO/32-333     AC A0A3M2T1E2.1
#=GS A0A2K5RTU1_CEBIM/43-303     AC A0A2K5RTU1.1
#=GS A0A3F3PRB7_9EURO/70-384     AC A0A3F3PRB7.1
#=GS E3KQQ6_PUCGT/90-406         AC E3KQQ6.1
#=GS A0A6P6YA51_DERPT/61-317     AC A0A6P6YA51.1
#=GS A0A6J0XXD6_ODOVR/43-303     AC A0A6J0XXD6.1
#=GS A0A0L7R2M2_9HYME/31-290     AC A0A0L7R2M2.1
#=GS A0A061EUT7_THECC/1-159      AC A0A061EUT7.1
#=GS A0A1Y2U9B2_9PEZI/25-314     AC A0A1Y2U9B2.1
#=GS A0A2G5VL93_9PELO/42-312     AC A0A2G5VL93.1
#=GS B9SVY9_RICCO/43-245         AC B9SVY9.1
#=GS A0A671QY45_9TELE/98-357     AC A0A671QY45.1
#=GS A0A2A9P140_9AGAR/48-301     AC A0A2A9P140.1
#=GS A0A4U0WBK5_9PEZI/26-322     AC A0A4U0WBK5.1
#=GS A0A2G5SWL5_9PELO/68-336     AC A0A2G5SWL5.1
#=GS R1FCN4_EMIHU/29-295         AC R1FCN4.1
#=GS G7XWL5_ASPKW/32-354         AC G7XWL5.1
#=GS A0A453GR09_AEGTS/44-295     AC A0A453GR09.1
#=GS W9YEQ9_9EURO/106-187        AC W9YEQ9.1
#=GS A0A2I2GLB5_9EURO/47-352     AC A0A2I2GLB5.1
#=GS Q4DVL8_TRYCC/49-299         AC Q4DVL8.1
#=GS A9S6W1_PHYPA/75-327         AC A9S6W1.1
#=GS A0A4X2LMM0_VOMUR/41-157     AC A0A4X2LMM0.1
#=GS A0A0W8D764_PHYNI/140-385    AC A0A0W8D764.1
#=GS A0A2K1QKL5_9PEZI/22-302     AC A0A2K1QKL5.1
#=GS A0A0C4EZQ9_PUCT1/83-395     AC A0A0C4EZQ9.1
#=GS A0A1B6Q8C5_SORBI/37-287     AC A0A1B6Q8C5.1
#=GS A0A4V6WKM6_9BASI/165-437    AC A0A4V6WKM6.1
#=GS K2MTW9_TRYCR/49-299         AC K2MTW9.1
#=GS A0A6I9XPB4_9SAUR/63-314     AC A0A6I9XPB4.1
#=GS A0A063BXP6_USTVR/17-323     AC A0A063BXP6.1
#=GS A0A1L9UA07_ASPBC/28-334     AC A0A1L9UA07.1
#=GS A0A367JYD9_RHIAZ/351-605    AC A0A367JYD9.1
#=GS J3L815_ORYBR/36-286         AC J3L815.1
#=GS A0A367Y9Q7_9ASCO/37-320     AC A0A367Y9Q7.1
#=GS A0A2Z7A0J9_9LAMI/13-261     AC A0A2Z7A0J9.1
#=GS B5MCU4_HUMAN/1-173          AC B5MCU4.1
#=GS A0A0J0XEZ1_9TREE/45-290     AC A0A0J0XEZ1.1
#=GS A0A5F5PYZ3_HORSE/40-284     AC A0A5F5PYZ3.1
#=GS A0A2G5BAF0_COERN/34-292     AC A0A2G5BAF0.1
#=GS B5MDU6_HUMAN/43-303         AC B5MDU6.1
#=GS A0A5D2VCW5_GOSMU/132-303    AC A0A5D2VCW5.1
#=GS A0A2P5WAI7_GOSBA/108-296    AC A0A2P5WAI7.1
#=GS A0A1S2ZBH7_ERIEU/43-129     AC A0A1S2ZBH7.1
#=GS A0A2S6CAM4_9PEZI/22-328     AC A0A2S6CAM4.1
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