#=GF ID   Lamprin
#=GF AC   PF06403.17
#=GF DE   Lamprin
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_15493 (release 9.0)
#=GF GA   34.00 34.00;
#=GF TC   34.10 34.90;
#=GF NC   33.70 33.40;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Lamprin
#=GF RN   [1]
#=GF RM   7678258
#=GF RT   Characterization of lamprin, an unusual matrix protein from
#=GF RT   lamprey cartilage. Implications for evolution, structure, and
#=GF RT   assembly of elastin and other fibrillar proteins. 
#=GF RA   Robson P, Wright GM, Sitarz E, Maiti A, Rawat M, Youson JH,
#=GF RA   Keeley FW; 
#=GF RL   J Biol Chem 1993;268:1440-1447.
#=GF DR   INTERPRO; IPR009437;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several lamprin proteins from the Sea
#=GF CC   lamprey Petromyzon marinus. Lamprin, an insoluble non-collagen,
#=GF CC   non-elastin protein, is the major connective tissue component of
#=GF CC   the fibrillar extracellular matrix of lamprey annular cartilage.
#=GF CC   Although not generally homologous to any other protein, soluble
#=GF CC   lamprins contain a tandemly repeated peptide sequence (GGLGY)
#=GF CC   which is present in both silkmoth chorion proteins and spider
#=GF CC   dragline silk. Strong homologies to this repeat sequence are
#=GF CC   also present in several mammalian and avian elastins. It is
#=GF CC   thought that these proteins share a structural motif which
#=GF CC   promotes self-aggregation and fibril formation in proteins
#=GF CC   through interdigitation of hydrophobic side chains in
#=GF CC   beta-sheet/beta-turn structures, a motif that has been preserved
#=GF CC   in recognisable form over several hundred million years of
#=GF CC   evolution [1].
#=GF SQ   9
#=GS A0A9P0I203_SPOLI/1-77    AC A0A9P0I203.1
#=GS A0A665WNZ9_ECHNA/3-105   AC A0A665WNZ9.1
#=GS A0A9J7EGD5_SPOLT/1-78    AC A0A9J7EGD5.1
#=GS A0A9W6SRA3_9ACTN/6-73    AC A0A9W6SRA3.1
#=GS A0A9P0BMU3_CHRIL/1-71    AC A0A9P0BMU3.1
#=GS A0A4C1UFE7_EUMVA/1-66    AC A0A4C1UFE7.1
#=GS A0A8S9X8R5_APOLU/96-206  AC A0A8S9X8R5.1
#=GS A0A9W7Y309_9FUNG/4-96    AC A0A9W7Y309.1
#=GS A0A9W7XV44_9FUNG/5-113   AC A0A9W7XV44.1
A0A9P0I203_SPOLI/1-77               ............mf-----RAVVLL...ASLalCH.GHA.VPVVA..HHAavvapvVAPVVA...GYAGHGY....GGHGFGGYGYGGLGYGGLGHAGLGHTGLGHAG-----------------------------------------------........................................
A0A665WNZ9_ECHNA/3-105              ......vtqfrthq----------L...ICI..HL.RPL.TPVWT..TEV......WSTVVF...VHGGLDH....RGLDHGGLDYAGLVHGGLDHRGLDYGGLDYAGLVHGGLDHRGLVHGGLE------------------------------clcvlsqvdlvviswi........................
A0A9J7EGD5_SPOLT/1-78               ............mf-----RAVVLL...ASLalCH.GHA.VPVVA..HHAavvapvVAPVVA...GYAGHGY....GGHGFGGYGYGGLGYGGLGHAGLGHAGLGHAG-----------------------------------------------l.......................................
A0A9W6SRA3_9ACTN/6-73               arsrittapmtrra-----------...---..--.---.-----..-RT......TGALVT...IGVPDPVtlgwAGLGWAGLGWAGLGWAGLGWAGLGWAGLGCP------------------------------------------------rlng....................................
A0A9P0BMU3_CHRIL/1-71               ..........mlrv-----AVLLAF...VVI..CN.GHA.VPLVA..PAH......HYPLLT...GYAGHGY....GGHGYGGYGYGGFGHGGLGHGGLGHGGLGHGG-----------------------------------------------........................................
A0A4C1UFE7_EUMVA/1-66               ............mi-----------...-VV..VL.SAA.CCVFA..EEA......KKTEKR...GLAGLGY....GGLGYSGLGYGGLGHGGLAYDGLGYGGYGYA------------------------------------------------aplay...................................
A0A8S9X8R5_APOLU/96-206             .........ktkmi-----QGALVFafvAVA..CV.AAE.PCVPA..KTT......CCTTSLnnlGYAGVGC....GGLGYSGLGYGGLGYAGLGYSGLGCGGLGYAG--LG-----YADNVGLGY--GAVAPVVAPAVAPAK------------ttcctta.................................
A0A9W7Y309_9FUNG/4-96               .......nialapi------VLVAV...ASM..AL.ATDgAPTAQphKRC......GGCGSI...GYGGVSY....GGIGYVGAGYGGVGYGGVGYGGLGYGGWGLPFAAS--------------------------------------------atnafnannnfahf..........................
A0A9W7XV44_9FUNG/5-113              ...........tsf---ATLAAAVL...AAI..ALtAHA.APVAD..MQK......RSDLVY...SGLG--Y....SGIGYGDLGYGGLGYGGLGYGGFGYG-WGIP------------------------------------------------lassvtnafnansnlanynddtlyvnnkdatvansnvntf
#=GC seq_cons                       ...........hhh......shhhh...ssl..sh.uts.sPVss..pcs......tusllh...GauGhuY....GGlGauGhGYGGLGaGGLGauGLGaGGLGauh...............................................h..s....................................
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