#=GF ID Lge1
#=GF AC PF11488.16
#=GF DE Transcriptional regulatory protein LGE1
#=GF AU Wood V;0000-0001-6330-7526
#=GF AU Coggill P;0000-0001-5731-1588
#=GF AU Andreeva A;0000-0002-0450-0091
#=GF SE Charwan C
#=GF GA 27.60 27.60;
#=GF TC 28.20 30.40;
#=GF NC 27.10 25.10;
#=GF BM hmmbuild --amino HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 90746521 --cpu 8 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 18374642
#=GF RT Histone ubiquitination: triggering gene activity.
#=GF RA Weake VM, Workman JL;
#=GF RL Mol Cell. 2008;29:653-663.
#=GF RN [2]
#=GF RM 17363370
#=GF RT HULC, a histone H2B ubiquitinating complex, modulates
#=GF RT heterochromatin independent of histone methylation in fission
#=GF RT yeast.
#=GF RA Zofall M, Grewal SI;
#=GF RL J Biol Chem. 2007;282:14065-14072.
#=GF RN [3]
#=GF RM 15528187
#=GF RT Transcriptional regulation by Lge1p requires a function
#=GF RT independent of its role in histone H2B ubiquitination.
#=GF RA Zhang X, Kolaczkowska A, Devaux F, Panwar SL, Hallstrom TC, Jacq
#=GF RA C, Moye-Rowley WS;
#=GF RL J Biol Chem. 2005;280:2759-2770.
#=GF RN [4]
#=GF RM 38331024
#=GF RT Histone H2B ubiquitylation: Connections to transcription and
#=GF RT effects on chromatin structure.
#=GF RA Fetian T, Grover A, Arndt KM;
#=GF RL Biochim Biophys Acta Gene Regul Mech. 2024;1867:195018.
#=GF RN [5]
#=GF RM 28628358
#=GF RT H2B ubiquitination: Conserved molecular mechanism, diverse
#=GF RT physiologic functions of the E3 ligase during meiosis.
#=GF RA Wang L, Cao C, Wang F, Zhao J, Li W;
#=GF RL Nucleus. 2017;8:461-468.
#=GF DR INTERPRO; IPR021581;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents a domain, comprising a single alpha-helix,
#=GF CC which is found in the Transcriptional regulatory protein LGE1
#=GF CC from S. cerevisiae and related proteins including the S. pombe
#=GF CC homolog Shf1. In yeast, the Lge1 protein facilitates
#=GF CC co-transcriptional H2B ubiquitination [1-4]. Multiple roles were
#=GF CC attributed to Lge1. In S. cerevisiae, Rad6 and Bre1 are present
#=GF CC in a complex, also containing Lge1. Bre1 is the H2B ubiquitin
#=GF CC ligase that interacts with acidic activators, such as Gal4, and
#=GF CC recruits Rad6 and its binding partner Lge1 to target promoters
#=GF CC [1]. Recent reports invoke a role for Lge1 in liquid-liquid
#=GF CC phase separation and formation of structure that concentrates
#=GF CC Bre1 in a shell that surrounds an Lge1 scaffolding core and
#=GF CC allows the recruitment of Rad6 and nucleosomes [4]. The domain
#=GF CC represented by this entry is involved in Bre1 binding. There is
#=GF CC no Lge1 homolog in humans but the WAC protein is thought to be
#=GF CC its functional analog [5].
#=GF SQ 83
#=GS A0A1E3QWD4_9ASCO/197-265 AC A0A1E3QWD4.1
#=GS A0A9P0QK34_9ASCO/189-259 AC A0A9P0QK34.1
#=GS G8BG77_CANPC/206-276 AC G8BG77.1
#=GS A0A7D9CX01_DEKBR/165-234 AC A0A7D9CX01.1
#=GS LGE1_YEAST/251-329 AC Q02796.1
#=GS H2AMF4_KAZAF/127-198 AC H2AMF4.1
#=GS G0VCK8_NAUCA/158-230 AC G0VCK8.1
#=GS A0A9W4XB64_9ASCO/67-135 AC A0A9W4XB64.1
#=GS A0A0C7MPY1_9SACH/144-218 AC A0A0C7MPY1.1
#=GS A0A2U9RA26_PICKU/308-377 AC A0A2U9RA26.1
#=GS W1Q893_OGAPD/161-230 AC W1Q893.1
#=GS A0A4P9Z9B4_9ASCO/67-137 AC A0A4P9Z9B4.1
#=GS A0A9P8PZF1_WICPI/315-403 AC A0A9P8PZF1.1
#=GS LGE1_CANGA/245-311 AC Q6FJC7.1
#=GS A0A1D8PT51_CANAL/183-253 AC A0A1D8PT51.1
#=GS A0A9W6YMG4_AMBMO/303-372 AC A0A9W6YMG4.1
#=GS G0WBJ4_NAUDC/324-397 AC G0WBJ4.1
#=GS A0A1G4MIC5_LACFM/136-210 AC A0A1G4MIC5.1
#=GS A0A1G4KFH7_9SACH/139-214 AC A0A1G4KFH7.1
#=GS A5E0R0_LODEL/268-338 AC A5E0R0.1
#=GS G8ZNR2_TORDE/131-205 AC G8ZNR2.1
#=GS A0A4P6XP68_9ASCO/325-395 AC A0A4P6XP68.1
#=GS A0A9W6SUL7_CANBO/487-556 AC A0A9W6SUL7.1
#=GS G3AK12_SPAPN/232-302 AC G3AK12.1
#=GS A0A9P7VAG7_9ASCO/95-165 AC A0A9P7VAG7.1
#=GS A0A448YHK9_BRENA/200-269 AC A0A448YHK9.1
#=GS A0A1X7R6F8_9SACH/227-299 AC A0A1X7R6F8.1
#=GS A5DND5_PICGU/208-278 AC A5DND5.2
#=GS C5DXY4_ZYGRC/218-292 AC C5DXY4.1
#=GS A0AAI9SXX7_9ASCO/274-344 AC A0AAI9SXX7.1
#=GS J8PGW2_SACAR/255-333 AC J8PGW2.1
#=GS A0A367XZU5_9ASCO/191-261 AC A0A367XZU5.1
#=GS C5M3I0_CANTT/202-272 AC C5M3I0.1
#=GS A3LXZ4_PICST/206-276 AC A3LXZ4.2
#=GS G8JQC4_ERECY/228-302 AC G8JQC4.1
#=GS C4R7N5_KOMPG/152-221 AC C4R7N5.1
#=GS LGE1_EREGS/167-241 AC Q75A59.1
#=GS A0A512UH08_9ASCO/316-386 AC A0A512UH08.1
#=GS SHF1_SCHPO/89-160 AC Q9UUI2.1
#=GS A0A9P8T5K0_9ASCO/217-326 AC A0A9P8T5K0.1
#=GS A0A8H7LCB8_9ASCO/297-367 AC A0A8H7LCB8.1
#=GS A0A1E3NHT4_9ASCO/345-414 AC A0A1E3NHT4.1
#=GS S9VR01_SCHCR/86-157 AC S9VR01.1
#=GS J5RTN8_SACK1/256-334 AC J5RTN8.1
#=GS J7S3B2_HUIN7/133-200 AC J7S3B2.1
#=GS A0A9P8NX47_9ASCO/161-230 AC A0A9P8NX47.1
#=GS C5DIE5_LACTC/107-181 AC C5DIE5.1
#=GS W6MUI9_9ASCO/164-234 AC W6MUI9.1
#=GS A0A1L0BXM4_9ASCO/201-271 AC A0A1L0BXM4.1
#=GS A0A1E4TNT8_PACTA/271-345 AC A0A1E4TNT8.1
#=GS A0A421JGV9_9ASCO/207-277 AC A0A421JGV9.1
#=GS K0KBE8_WICCF/192-276 AC K0KBE8.1
#=GS A0A1G4J5N4_9SACH/142-216 AC A0A1G4J5N4.1
#=GS A0A642UNA7_DIURU/219-289 AC A0A642UNA7.1
#=GS I2H8C1_HENB6/209-286 AC I2H8C1.1
#=GS A0A367YAJ1_9ASCO/197-267 AC A0A367YAJ1.1
#=GS A0A9P8PBW7_9ASCO/156-225 AC A0A9P8PBW7.1
#=GS A0A2V1AZX2_9ASCO/226-296 AC A0A2V1AZX2.1
#=GS A0A8J5QNJ6_9ASCO/203-273 AC A0A8J5QNJ6.1
#=GS A0A9P7BH56_9ASCO/312-381 AC A0A9P7BH56.1
#=GS A0A7H9HZF9_9SACH/216-290 AC A0A7H9HZF9.1
#=GS LGE1_KLULA/158-228 AC Q6CVS3.1
#=GS A0A2P7YIK7_9ASCO/220-290 AC A0A2P7YIK7.1
#=GS A7TTW4_VANPO/230-302 AC A7TTW4.1
#=GS A0A1E4SUB3_9ASCO/246-315 AC A0A1E4SUB3.1
#=GS A0A376BBJ3_9ASCO/463-546 AC A0A376BBJ3.1
#=GS A0A4T0WWT0_9ASCO/240-309 AC A0A4T0WWT0.1
#=GS A0A1E4RKJ2_9ASCO/222-292 AC A0A1E4RKJ2.1
#=GS A0A421JHH0_9ASCO/206-275 AC A0A421JHH0.1
#=GS G8YNI3_PICSO/193-263 AC G8YNI3.1
#=GS A0A8H6BVB5_CANAX/184-254 AC A0A8H6BVB5.1
#=GS G8YL53_PICSO/193-263 AC G8YL53.1
#=GS A0A1A0H921_9ASCO/210-280 AC A0A1A0H921.1
#=GS A0A2H0ZVR8_CANAR/224-294 AC A0A2H0ZVR8.1
#=GS A0A1E3P9H2_WICAA/208-290 AC A0A1E3P9H2.1
#=GS A0A1Q2YE40_9ASCO/495-564 AC A0A1Q2YE40.1
#=GS G3AWP3_CANTC/141-206 AC G3AWP3.1
#=GS C4YB51_CLAL4/165-235 AC C4YB51.1
#=GS A0A7H9B0A2_ZYGMR/233-307 AC A0A7H9B0A2.1
#=GS Q6BIG1_DEBHA/208-278 AC Q6BIG1.2
#=GS G8BRE2_TETPH/238-309 AC G8BRE2.1
#=GS A0A1E4SRA1_9ASCO/177-247 AC A0A1E4SRA1.1
#=GS M3K0J5_CANMX/171-241 AC M3K0J5.1
A0A1E3QWD4_9ASCO/197-265 ..........................SPWVKILKMG.............V--Q.......AEQFQKREAALQENESRLMEFELKRFKTERHLETLAGQVARDELNVQLTDENLDNIT....
A0A9P0QK34_9ASCO/189-259 ..........................SHWVEILQIK.............DEST.......AKTLDIRQNELDAVDKTLLELNQARHNLEISLSHLERHAQNEDLNVQITNEKLEEFS....
G8BG77_CANPC/206-276 ..........................NPWINIMGIT.............DEAQ.......QASLEANYNEQTATDETIRELQRKKMKLEMAISSLEKHAAREELHVQLTTEKLDEF-v...
A0A7D9CX01_DEKBR/165-234 ..........................NHWVTRLNLK.............GEM-.......RKDISRLFERLESINKSLQKESSRKIIAEAEVEKYNRFARSENLKCQLMEERLETF-d...
LGE1_YEAST/251-329 ..........................SPFIYLTDFDknvk.....ktnnTESE.......CEKAREVFKESDSIDSALEELNLKINSNELELRLLNNQCDKHALNIQLTQEKLDSLL....
H2AMF4_KAZAF/127-198 ..........................SPFVYMMGLDk...........yG-AD.......MNEIDKIFEEENKINMELEHLKFTILTNEIEDSILNSMVERNVLNVQLTQEKLDSLL....
G0VCK8_NAUCA/158-230 ..........................SPFLYLTELDq...........gDEAS.......VAEAKKVLAASSTLDGALRASYLRRLASETEVSLLSNQCERDTLNVQLTQEKLDSLL....
A0A9W4XB64_9ASCO/67-135 ..........................NPWIPLLELK.............GEST.......IQKFESNFKESNQLNQEILVLEKKQMKIELELKNLELQAKRIELNQQDMTEKL----ki..
A0A0C7MPY1_9SACH/144-218 ..........................SPAYFLTGLDey.........ttDEPE.......KSRILSVLREDDDIDLKLEEQKLQLCKSELELGLLSTQSEKDALNVQLTQENLDAIL....
A0A2U9RA26_PICKU/308-377 ..........................KHWISRIHVH.............GDM-.......RKFLSRAFDSLDVANASLLNIGARRAELEIDVERYNRLLKAEDERVRLAEEKLEAM-d...
W1Q893_OGAPD/161-230 ..........................NHWVIRLRVS.............GET-.......KASLSKSFDELDKINKVLAESAIKRLHLEMDVERYSRAGRSEDVRCRLAEEKLEALN....
A0A4P9Z9B4_9ASCO/67-137 ..........................SPWIAILGIK.............DPKV.......ASQMYSTYRAEAALNEKLSKLQAAANKLESTLATYKIYAKRDALNVQQCSEKLEEF-m...
A0A9P8PZF1_WICPI/315-403 ..........................SPLVDILSLNsfrhv..keitasGSTTaaelsklKESLNEYHDKSTNFQKFKLEWEKDHILSDFHIERLKAQVRRDEINVKCTEEKLDSIT....
LGE1_CANGA/245-311 ......................qgyl-------EIM.............DQN-.......SSSTTSVTQTEIELDEKLREMNSQVFRTMCELALVENQYTRDTLNVQLTQEKLDTLL....
A0A1D8PT51_CANAL/183-253 ..........................NPWINIMRIE.............DEPT.......QNKLEKSYNDMTELDSSILELQKSKLKLEMSMSLIEKQIDKEGLHVELTNEKLEEF-a...
A0A9W6YMG4_AMBMO/303-372 ..........................NHWVLRLGLE.............GKT-.......KESITNSMSELKKINEIIASSSEKRLKLEMEVAKLDRLSKNEELRCKLADEKLEAM-d...
G0WBJ4_NAUDC/324-397 ..........................SPFFYLTNLNq..........feDTNK.......IEEIKETLNENNILNSKLNENHLKMIKIQLDLNLLINQHERDSLNVQLTQEKLDSLL....
A0A1G4MIC5_LACFM/136-210 ..........................SPFLYLTELDks.........vdSEKD.......LAYIREVFQDSDSIDAKLEEQKLQIWKNELELGLLSTQSEKDALSVQLTQEKLDALL....
A0A1G4KFH7_9SACH/139-214 .........................w-PFVYLTGLDqt........migNEPE.......TSKVRDIFRQNDSIDAKLEEQKLQLWKSELELGLLSTQCEKDILNVRLTQENLDALL....
A5E0R0_LODEL/268-338 ..........................NPWINIMGIT.............DEPT.......QKLLEERYAEMTKFDDKILELQKNKLKLELSMSSLEKLAAREKLHVQLTSEKLEEF-i...
G8ZNR2_TORDE/131-205 ..........................SCFYYLTDLDks.........tdDPVE.......LQKIRETLREGEQLDRELETHNLKLLKTELELGLLTTQCERDALNVQSTQEKLDSLL....
A0A4P6XP68_9ASCO/325-395 ..........................NPWISLLRLG.............EGKT.......AARLEQNHKELAAVNNKLAELQSEKIKLTCALSTLEVYAKRDALNSEICSEKLDEFT....
A0A9W6SUL7_CANBO/487-556 ..........................NHWVSTLKLS.............GDL-.......KESTNKLFEELDSVNKNINELYQKSFNLEIEVEKFGRLSRTENLKSRLTDEKLESIN....
G3AK12_SPAPN/232-302 ..........................NPWINIMGIQ.............DETT.......QTKLESRFNDLSKVDKEIINLQKAKLKLESDVSNLDKQAAREELHVQLTTEKLEEFT....
A0A9P7VAG7_9ASCO/95-165 ..........................NPWIQLLHIK.............DEHT.......RTTLQQRYLELEEVDARLMELQKSRLAMESAAKTLEIYAAKEALNVSITNDKLEEFT....
A0A448YHK9_BRENA/200-269 ..........................THWVTRLHLT.............GEM-.......KNVMQSHFDELSRISDTLFEAQEKRFQAEMEVAKYNRLTTSENLRTQLAEEKLEALN....
A0A1X7R6F8_9SACH/227-299 ........................sv--YLRLTELD.............NLTNi.....sKNEINSIFNENDEIDNKLNDVKLDFVQREMEVINLINSIERDNLNVNLTQENLDALL....
A5DND5_PICGU/208-278 ..........................SPWISILQIK.............DGPT.......RKKLEERYNELDQVDRELASASRECWQLQRALQTLEHHAAREALQVQQTSEKLDELS....
C5DXY4_ZYGRC/218-292 ..........................SPFYYLTDLDks.........sdDPKE.......LESIRQMFKESDRLDKQLEEHNFNLLKNELELGLLATQCEKDKLSVQLTQEKLDTFL....
A0AAI9SXX7_9ASCO/274-344 ..........................NPWINIMGIT.............DEAT.......QKTLEERYIELSQVEDKILELQKSKLRLEMNMSSLEKQAAREMLNVQLTTEKLEEF-v...
J8PGW2_SACAR/255-333 .........................s-AFLYLTDFDknvr.....ktsnTEGE.......CDRAREVFKESDVIDAALQELNLKVNSNELELRHLNNQCDKHALNIQLTQEKLDSLL....
A0A367XZU5_9ASCO/191-261 ..........................NPWIHILQID.............DETT.......QNKLESGYDELKSVDHGISELQKSKMKLEMSMSLLEKQIDREALHVELTNEKLEEFT....
C5M3I0_CANTT/202-272 ..........................NPWINILQID.............DETT.......QNKLETNYDELRKIDSSISDLQKSKLKLELSMSVLEKQIDRESLHVELTNEKLEEFT....
A3LXZ4_PICST/206-276 ..........................NPWIEIMEIN.............DETT.......QETLETRYNELGYVNSDIRQLQLAKRKLEGSVLNLERQAEREALHVQITNDKLEEFT....
G8JQC4_ERECY/228-302 ..........................NPIYYLTELDks.........tdDLKK.......LEDIKKVFQESDELDHKLEQQKLVMWKAELELVLLDTQSEKDALNVQLNQENLDALL....
C4R7N5_KOMPG/152-221 ..........................SYWVARLKID.............GQL-.......REKIQTSFESLESTDDRTRNLLQKSLALEIEADNLARFVENEALRVKLCEEKLENIN....
LGE1_EREGS/167-241 .........................d-PLFHLTELDrs.........tdDPRQ.......LDEMRRIFKDSVQLDQKLEQQKLAMWRTELELSLLDTQSAKDALNVQLNQENLDALL....
A0A512UH08_9ASCO/316-386 ..........................NPWISLLRLG.............EGKT.......AARLDHNYKDLASVNDRLAELQSEKIKLACALSTLEVYAKRDALNVEICNEKLDEFT....
SHF1_SCHPO/89-160 ........................tn---VELPKINl...........pDSSL.......SSKLQSCKSACENSSQSLLNVEQQYAQQVHFWEKIRTDIYREGLRSDAAVKSLNDF-v...
A0A9P8T5K0_9ASCO/217-326 enisrteipkieqteelktdieesqs-VIVNLLSLNqieaq...fskseDLSKik...eiRASLEKSSNDSEEYLRKKKEFEINDITNDFEIQSLKVQVKRDELNVELTQEKLDSIS....
A0A8H7LCB8_9ASCO/297-367 ..........................NPWISLLRLG.............EGKT.......AARLEQNHKELAAVNNKLAELQSEKIKLTCALSTLEVYAKRDALNSEICSEKLDEFT....
A0A1E3NHT4_9ASCO/345-414 ..........................KHWIERIQAS.............GEM-.......RKTLSRHFNELDAVNSKLLDVGTRRAELEIEVNRYNRVLKAEEDRVRLAEEKLEAMN....
S9VR01_SCHCR/86-157 ....................deqqtp-----LIKLP.............DAGL.......ANQLKSTKKAWQDTSKNVSNFEHEYLQQKYFWEKVRPDVFREQLRSNTAEKSLDDF-v...
J5RTN8_SACK1/256-334 ..........................SPFLYLTDFDknik.....ksnnTENE.......CEKAREVLKESDLIDSALEDLNLKVNSNVLELRLLNNQCDKHALNIQLTQEKLDSLL....
J7S3B2_HUIN7/133-200 .........................q-PVFELTRLS.............E---.......LDGTSDIPPLNDEIDTQLQQLKLRITTTEHELLQLTAQCARDALNVSQTQEKLNALL....
A0A9P8NX47_9ASCO/161-230 ..........................NHWVIRLRVS.............GET-.......KTSLSKSFDELDKINKVLAESAVKRLHLEMDVERYSRAGRSEEVRCRLAEEKLEALN....
C5DIE5_LACTC/107-181 ..........................SPFYYLTGLDqs.........seNEQE.......LLRIRNLFKEDDSIDARLQEQKLQLCKSELELGLLSTQCEKDALNVQLTQENLDALL....
W6MUI9_9ASCO/164-234 ..........................HHWVVRLDVL............pDDA-.......KKKLNDALTECDLKTEQLLKLLKKKDEIEQKLEASKRQCHVEGLRAQLTQEKLEALN....
A0A1L0BXM4_9ASCO/201-271 .........................d-PWITILRIG.............EGKT.......AARMDAAYKELSNVNKTISELQADAMKLTSLLEMLEVYASRDALNVEISKEKLDEFT....
A0A1E4TNT8_PACTA/271-345 ..........................SLWVSLLGVD.............KIPNns...afKAEFLKNLKENDKIEQKLVELKEKCFGLTLDIESLQRQVAKNELQVNLTEEKLADI-s...
A0A421JGV9_9ASCO/207-277 ..........................NPWISILHIK.............DEPT.......RKKLEERYNDLGQVDRELASASRECWQLQRALQTLEHHAAREALQVQQTSEKLDDLN....
K0KBE8_WICCF/192-276 ..........................SPWIELLRLNekrsg..leqidsD--Lkl..kelIKEQEEIYQEQEILQKKYLDQKLKNLKLEFEVGTLKEISNKDSLNVELTQEKLDTI-s...
A0A1G4J5N4_9SACH/142-216 ..........................SPIYHLTGLHdy.........aeDEQE.......RSMIRALLREDENIDARLEEQKLQLCKSELELGLLSTQSEKDALNVRLTQENLDALL....
A0A642UNA7_DIURU/219-289 ..........................NPWVDHFGVT.............DPAL.......VQSMESSFKQLREAEIRLAELEATRLKTLASMNNYERLLKKEALSIALQTERVEEL-a...
I2H8C1_HENB6/209-286 ..........................SPFFYLTDIDksi......dksiDPTL.......FNRTKQIYEISEELDKKLYDHEFQLFKNELEFGLLTSQSERDQLNVQLTQEKLDSLL....
A0A367YAJ1_9ASCO/197-267 ..........................NPWIHILQID.............DETT.......QNKLESGYDELKSVDHGISELQKSKMKLEMSMSLLEKQIDREALHVELTNEKLEEFT....
A0A9P8PBW7_9ASCO/156-225 .........................v-HWITRLRVG.............GEM-.......KNSLSKQFEELDKINKIIDQAAEKRLQLEMDVERYSRAGRSEDVRCKLAEEKLEALN....
A0A2V1AZX2_9ASCO/226-296 .........................d-PWISILHIR.............DSKV.......ASRLEARHQELANVNRSLGQLQAQRHKLKAHMDLLDVYAKRDALNVELTSEKLDEFT....
A0A8J5QNJ6_9ASCO/203-273 ..........................NPWINIMGIV.............DEQT.......QNKLEARFNELSKVDKEIMELQKSKLKLENYMASLEKQATREELHVQLTNEKLEEFT....
A0A9P7BH56_9ASCO/312-381 ..........................KHWIERIHVS.............GDA-.......KKSISKCFDELDSANDRLLDIGARRIELEIAINRYNRALKAEEERVRIGEEKLESMN....
A0A7H9HZF9_9SACH/216-290 ........................sg--FLYLTDLDks.........tdDPAE.......LAKIRQTLREGERLDKDLESHSLKLLKTELELELLTTQCERDALNVQLTQEKLDSLL....
LGE1_KLULA/158-228 ..........................NPFIYMMSND.............DHSR.......TSKLKEVYKENDQIDNKLEELKLKIFKDELELGLMSTQCEKDALNVQLTQEKLDSLL....
A0A2P7YIK7_9ASCO/220-290 .........................d-PWISILHIR.............DGKV.......ALRLEARHQELANVNRSLGLLQAQVHKLKAHMDLLDVYAKRDALNVEMTSEKLDEFT....
A7TTW4_VANPO/230-302 .........................t-PMYYLTRQD.............ENKVe.....eQETFKRIYKTSEEIDDKLEDIKFKIIKSELEYNLMTTQGEKDSLNVQLTQENLDSLL....
A0A1E4SUB3_9ASCO/246-315 ..........................NHWVSRLQLV.............GED-.......KDTMNKLFEQLQDINTVISNENIKNFQLQIENSRLERIMKSEENKCKFADEKLESI-e...
A0A376BBJ3_9ASCO/463-546 .....svymyltdlykvdnlpqdnts-------SID.............GGA-.......LKKIRGVFKENTEIDEKLESLKLQNLERQLELEILNIQCEKDSLNVQLTQEKLDSLL....
A0A4T0WWT0_9ASCO/240-309 ..........................KHWIKRINVT.............GDV-.......KSSIVSLFDDLDDTNSKLLELGSRCMQLEIDVLKYNRILRTEEERVSLTEESLEAM-e...
A0A1E4RKJ2_9ASCO/222-292 ..........................NPWIPILHIK.............DPKT.......QAVLESRYEDLLKVDKELSQLQLTRFKLQNSVQSLDRSMEREALHVQLTNEKLEEFT....
A0A421JHH0_9ASCO/206-275 ..........................NPWINIMGIQ.............DEST.......QTKLESRFNELSKLDKEILNLQKSKLKLESNVSSLDKQAVREELHVQLTTEN-----fisl
G8YNI3_PICSO/193-263 .........................c-PWIPILQID.............DPNS.......KSRLESYQEEQDKIDKDILDLQHARWKLEVSLTNSNRHARREELMVQLTNEKLEEFT....
A0A8H6BVB5_CANAX/184-254 ..........................NPWINIMRIE.............DEPT.......QNKLEKSYNDMTELDSSILELQKSKLKLEMSMSLIEKQIDKEGLHVELTNEKLEEF-a...
G8YL53_PICSO/193-263 .........................c-PWIPILQID.............DPNS.......KARLEQYQEEQDKIDKDILDLQHARWKLEVSLTNSNRHARREELMVQLTNEKLEEFT....
A0A1A0H921_9ASCO/210-280 ..........................NPWITLLKLG.............QGKT.......AARVELNYKEISRVNDRLAELQSEKVKLACALSTLEVYAKRDALNVEICSEKLDEFT....
A0A2H0ZVR8_CANAR/224-294 .........................d-PWISILQIS.............DEKV.......AKRLESRHLELANVNKTLGQLQLQRHKLKAHMDLLDVYAKRDALNVEMTSEKLDEF-a...
A0A1E3P9H2_WICAA/208-290 ..........................SPWIQILKLDaanfedselnfklK--E......vMEEQEAIYADQEKIENQIKEQKIKNLKIQMELGVLKACAEKDALNVELTQEKLDTI-s...
A0A1Q2YE40_9ASCO/495-564 ..........................KHWIERIKAS.............GEM-.......RKTLSRYFNELDAVNSKLLDVGTRRAELEIEVNRYNRVLKAEEDRVRLAEEKLEAMN....
G3AWP3_CANTC/141-206 ................hatpisshap----------.............----.......-SKLTSKTEELSEIDDELVKLRADLINKTGNYALLVSQLDKEQLNIDLNNEKLSEM-s...
C4YB51_CLAL4/165-235 ..........................SPWVAIMRLG.............DGKS.......AARVNAAANELHTMNQKLSELQAERMKLASSLATLEVYAQRDALSVSVSAEKLDEF-v...
A0A7H9B0A2_ZYGMR/233-307 ..........................SPFFYLTDLDks.........tdNSVE.......LDRIKHILRESDSLDKKIEEEKLRILKDELELSLLTTQCERDYLNVQLTQEKLDSLL....
Q6BIG1_DEBHA/208-278 ..........................NPWITILQIK.............DDPT.......KQAFEHTHEELGRLDKELHELQHAKLLLENSVANLERQALREELHVQITNEKLEEFT....
G8BRE2_TETPH/238-309 ..........................SPFYYLTNLN............eDKKN.......ADDIKKVFIDNDNIDKSLQAIKYKILKTELEYDLLNTQGERDALNVQLTQENLDSIL....
A0A1E4SRA1_9ASCO/177-247 ..........................NPWIDTLGIK.............DLAT.......IDTLEARYNELQATNKDIIELQQAKLKLERSVATLENQASREELHVQLTTEKLDEFT....
M3K0J5_CANMX/171-241 ..........................NPWINIMQIE.............DEAT.......QNKLETSYNEMTTLDASIADLQKSKLKLEMSMSLLEKQVDREALHVELASEKLEEF-a...
#=GC seq_cons ..........................sPWltlhpls.............-ptp.......tsclcptapEhsplspcLt-lphpph+hEhclshLpppsc+-sLpVpLTpEKL-ph.....
//
