GenomeNet

Database: Pfam
Entry: Lipoprotein_7
LinkDB: Lipoprotein_7
Original site: Lipoprotein_7 
#=GF ID   Lipoprotein_7
#=GF AC   PF01540.19
#=GF DE   Adhesin lipoprotein
#=GF AU   Bashton M;0000-0002-6847-1525
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_615 (release 4.0)
#=GF GA   24.10 24.10;
#=GF TC   25.40 25.40;
#=GF NC   23.20 23.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8698503
#=GF RT   Molecular basis of size and antigenic variation of a Mycoplasma
#=GF RT   hominis adhesin encoded by divergent vaa genes. 
#=GF RA   Zhang Q, Wise KS; 
#=GF RL   Infect Immun 1996;64:2737-2744.
#=GF RN   [2]
#=GF RM   8926064
#=GF RT   Repetitive elements of the Mycoplasma hominis adhesin p50 can be
#=GF RT   differentiated by monoclonal antibodies. 
#=GF RA   Henrich B, Kitzerow A, Feldmann RC, Schaal H, Hadding U; 
#=GF RL   Infect Immun 1996;64:4027-4034.
#=GF DR   INTERPRO; IPR002520;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of the p50 and variable
#=GF CC   adherence-associated antigen (Vaa) adhesins from Mycoplasma
#=GF CC   hominis. M. hominis is a mycoplasma associated with human
#=GF CC   urogenital diseases, pneumonia, and septic arthritis [1]. An
#=GF CC   adhesin is a cell surface molecule that mediates adhesion to
#=GF CC   other cells or to the surrounding surface or substrate. The Vaa
#=GF CC   antigen is a 50-kDa surface lipoprotein that has four tandem
#=GF CC   repetitive DNA sequences encoding a periodic peptide structure,
#=GF CC   and is highly immunogenic in the human host [1]. p50 is also a
#=GF CC   50-kDa lipoprotein, having three repeats A,B and C, that may be
#=GF CC   a tetramer of 191-kDa in its native environment [2].
#=GF SQ   4
#=GS D1J8D5_MYCHP/364-471     AC D1J8D5.1
#=GS D1J8D5_MYCHP/133-254     AC D1J8D5.1
#=GS A0A1I3LLE7_9FLAO/40-134  AC A0A1I3LLE7.1
#=GS D1J8D5_MYCHP/255-363     AC D1J8D5.1
D1J8D5_MYCHP/364-471                .............LSHEISEFSNSVKKTISELE.KKFKIDDttnkeeakKFKNELENFADQLLNKSHEID..KFVTVTSARGDFSLSELESFKSFNTTWFNEMKSEWARVQEAWKDQLKEI.........S--------------tk.....
D1J8D5_MYCHP/133-254                .............LSEKIQSFADTIALTITKLEgKKFEIDE........TFKKQLISTIELLNKKSVEVK..TFATVNTIKKDFLLSELESFKEFNTSWLEKIVSEWEEVKKAWSKELAEIkadddkklaEENQKIQNGIAELTK.......
A0A1I3LLE7_9FLAO/40-134             asmegkgivntpd--------------------.----IFN........EVKENLQKTVELIQDKSTEVVfiPFTSKPHTRKSFTIERLNEIKEYISK-L-KVEKGDTNIVDAWREGVEEI.........DP-------------skvnylf
D1J8D5_MYCHP/255-363                .............LSKENSDLAQTIEETIAKLE.KKFQIPK........DFKEKLTSTIKLLNKKANEIN..TFVSTVSKKTEFVLEELESFKELNTLQFNEIKTEWAKVQEAWKNELTEI.........---NSIIKGVEELKK.......
#=GC seq_cons                       .............LScc.pphupolt.TIscLE.KKFpIsc........cFKcpLpsTl-LLpcKSsEls..sFsossot+p-FsLpELESFKEaNTp.hpclcoEWscVp-AW+cpLpEI.........p.....................
//
DBGET integrated database retrieval system