GenomeNet

Database: Pfam
Entry: Longin_2
LinkDB: Longin_2
Original site: Longin_2 
#=GF ID   Longin_2
#=GF AC   PF18639.4
#=GF DE   Yeast longin domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08503
#=GF GA   27.30 27.30;
#=GF TC   33.10 30.30;
#=GF NC   26.30 25.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0431
#=GF RN   [1]
#=GF RM   26631379
#=GF RT   Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein.
#=GF RA   Pacitto A, Ascher DB, Wong LH, Blaszczyk BK, Nookala RK, Zhang
#=GF RA   N, Dokudovskaya S, Levine TP, Blundell TL;
#=GF RL   Open Biol. 2015;5:150174.
#=GF DR   INTERPRO; IPR041153;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a longin domain which is found in the N-terminal region
#=GF CC   of Lst4 proteins in yeast. Lst4 is the Fnip1/2 orthologue found
#=GF CC   in mammals. Lst4 forms a complex with Lst7 and are targeted to
#=GF CC   the vacuole when the cells are starved of carbon, and to a
#=GF CC   lesser extent nitrogen. Lst4 and Fnip1/2 belong to the DENN
#=GF CC   family of proteins which comprise an N-terminal longin domain,
#=GF CC   commonly found in a variety of trafficking proteins, and a
#=GF CC   C-terminal DENN domain. This domain is made up of a core
#=GF CC   five-strand beta-sheet, with one short alpha-helix [1].
#=GF SQ   68
#=GS A0A367XMF8_9ASCO/86-336   AC A0A367XMF8.1
#=GS A0A1U7EPX9_9SACH/91-254   AC A0A1U7EPX9.1
#=GS A0A1E4SCH8_9ASCO/60-302   AC A0A1E4SCH8.1
#=GS A0A1S7HRC0_9SACH/90-253   AC A0A1S7HRC0.1
#=GS A0A4P6XKE3_9ASCO/76-392   AC A0A4P6XKE3.1
#=GS A0A512U9A5_9ASCO/88-407   AC A0A512U9A5.1
#=GS C4QY02_KOMPG/75-300       AC C4QY02.1
#=GS A0A376B0V9_9ASCO/120-215  AC A0A376B0V9.1
#=GS LST4_ASHGO/71-229         AC Q757Y7.2
#=GS A0A1X7R0Y1_9SACH/216-403  AC A0A1X7R0Y1.1
#=GS W6MV34_9ASCO/56-276       AC W6MV34.1
#=GS A0A1L0BZN6_9ASCO/63-353   AC A0A1L0BZN6.1
#=GS A0A2V1AP52_9ASCO/61-360   AC A0A2V1AP52.1
#=GS A0A1Q2YEG5_9ASCO/151-357  AC A0A1Q2YEG5.1
#=GS M3HTS6_CANMX/84-346       AC M3HTS6.1
#=GS A0A1D8PGY3_CANAL/67-315   AC A0A1D8PGY3.1
#=GS A0A1G4KBI5_9SACH/51-206   AC A0A1G4KBI5.1
#=GS A0A1A0H9D2_9ASCO/54-318   AC A0A1A0H9D2.1
#=GS Q6BM05_DEBHA/90-359       AC Q6BM05.2
#=GS G8ZYV2_TORDC/103-269      AC G8ZYV2.1
#=GS LST4_CANGA/38-209         AC Q6FJ91.1
#=GS H2AXH0_KAZAF/99-268       AC H2AXH0.1
#=GS G3BBE9_CANTC/60-295       AC G3BBE9.1
#=GS A0A0C7NDN7_9SACH/52-207   AC A0A0C7NDN7.1
#=GS A0A367YLP4_9ASCO/86-339   AC A0A367YLP4.1
#=GS C5E178_ZYGRC/89-253       AC C5E178.1
#=GS G8Y7B9_PICSO/84-352       AC G8Y7B9.1
#=GS LST4_VANPO/102-271        AC A7TFI4.1
#=GS A0A2H0ZMI6_CANAR/63-361   AC A0A2H0ZMI6.1
#=GS A5DV88_LODEL/188-404      AC A5DV88.1
#=GS A0A1E4REB1_9ASCO/74-208   AC A0A1E4REB1.1
#=GS A3LN66_PICST/76-321       AC A3LN66.2
#=GS I2H1W9_TETBL/147-323      AC I2H1W9.1
#=GS A0A1G4MGZ6_LACFM/51-206   AC A0A1G4MGZ6.1
#=GS A0A642UPL2_DIURU/58-269   AC A0A642UPL2.1
#=GS G8BU48_TETPH/134-344      AC G8BU48.1
#=GS I2JY10_DEKBR/1-195        AC I2JY10.1
#=GS A0A2U9R4Z0_PICKU/131-346  AC A0A2U9R4Z0.1
#=GS A0A1G4JBN0_9SACH/52-207   AC A0A1G4JBN0.1
#=GS A0A4P9ZGX9_9ASCO/178-390  AC A0A4P9ZGX9.1
#=GS A0A7H9B4H4_ZYGMR/116-275  AC A0A7H9B4H4.1
#=GS J5PI39_SACK1/118-288      AC J5PI39.1
#=GS A0A1E3PBU9_WICAA/54-220   AC A0A1E3PBU9.1
#=GS G0W357_NAUDC/144-324      AC G0W357.1
#=GS A0A376B0V9_9ASCO/230-363  AC A0A376B0V9.1
#=GS A0A421JFL0_9ASCO/72-302   AC A0A421JFL0.1
#=GS G3AMR0_SPAPN/82-442       AC G3AMR0.1
#=GS A0A4V4NFE8_9ASCO/101-302  AC A0A4V4NFE8.1
#=GS A0A2P7YX11_9ASCO/60-343   AC A0A2P7YX11.1
#=GS G8JX27_ERECY/76-245       AC G8JX27.1
#=GS A5DE16_PICGU/72-305       AC A5DE16.2
#=GS G8BE00_CANPC/59-320       AC G8BE00.1
#=GS K0KHI5_WICCF/66-237       AC K0KHI5.1
#=GS C5M5S4_CANTT/84-343       AC C5M5S4.1
#=GS A0A1E3NPJ5_9ASCO/147-352  AC A0A1E3NPJ5.1
#=GS A0A1E5RH26_9ASCO/234-473  AC A0A1E5RH26.1
#=GS LST4_YEAST/118-288        AC P34239.1
#=GS A0A7H9HMH8_9SACH/102-265  AC A0A7H9HMH8.1
#=GS C4Y9S0_CLAL4/41-272       AC C4Y9S0.1
#=GS C5DKG7_LACTC/52-207       AC C5DKG7.1
#=GS A0A1E3QNV2_9ASCO/79-290   AC A0A1E3QNV2.1
#=GS G0VAP5_NAUCC/150-320      AC G0VAP5.1
#=GS LST4_KLULA/65-222         AC Q6CXP4.1
#=GS LST4_KLULA/65-222         DR PDB; 4ZY8 D; 10-167;
#=GS LST4_KLULA/65-222         DR PDB; 4ZY8 A; 10-167;
#=GS LST4_KLULA/65-222         DR PDB; 4ZY8 C; 10-167;
#=GS LST4_KLULA/65-222         DR PDB; 4ZY8 B; 10-167;
#=GS J7S4B6_KAZNA/132-295      AC J7S4B6.1
#=GS A0A1E4RWV6_CYBJN/79-245   AC A0A1E4RWV6.1
#=GS A0A421JVB8_9ASCO/82-336   AC A0A421JVB8.1
#=GS W1QGG3_OGAPD/59-261       AC W1QGG3.1
#=GS A0A1E4TPH7_PACTA/84-290   AC A0A1E4TPH7.1
A0A367XMF8_9ASCO/86-336              .................l-FRIIISQDGGNLRSK---QVLFDSACdvpspdt..............................kplqhqhQ----.-------Qplqdlsnikkp.........................skpmvtskvyhnVS............DLNDYMFGC.GLPSNE..N...QSTTKIHTLPPltns........................iygpY...SAVLITRLFSISDGEftelpnlpnqdanewqphpal.............rvkessirkvsikddssknnnvNSRFSIGVVIPle.siCSMPDVIFNNWHE.ITHFMILLQKLI....YKK.LLMH.....................................................-LNAGLNYDTN.....-N--------..-........-----------nftgcqylikkriqfpnyilqgdyeinpqlvkli....................................................................................................
A0A1U7EPX9_9SACH/91-254              ..................SFRILIAEETGRM-CRNNYSVVMD--Y............................................STAR-.GQQIEQIR................................................PN............ELKEYIFGS.PIRTAD..L...SQGSKFRNIPN................................S...GLIMITRVFYWEQHS........................................................TNRLTVSLCVP.....AILLPVIPEAWGH.ITKWLDQCQNII....EAT.LDRHrst..............................................rdkgMKDGLLPNDLN.....VHFPKECDSI..V........QLLQHKLIPCL......................................................................................................................................
A0A1E4SCH8_9ASCO/60-302              ................lv--RIIVSQDGGNLRSK---QVLFDSANepespgsnsv........................fcksplaskhASHNR.YMMMSKIH................................................HNs..........sELNDYMFGC.GLPTNQ..T...HSSTKIHILPAlnsl........................vygsS...RSVLITRLFSITDLDsseppglssiegpssswnptptlpikd.ssirnhpfakmsncqlasspsskpnnniNSRFAIGIIVPle.slYDIGDIVFNNWNE.LSHYLILLQRFT....TKK.LIHE.....................................................-LNSGLMNNLN.....IN--------..-........-----------dsptscpcpyivnkriq.....................................................................................................................
A0A1S7HRC0_9SACH/90-253              ..................SFRILIAEETGRM-CRNNYSVVMD--Y............................................STAR-.GQQIEQIR................................................PN............ELKEYIFGS.PIRTAD..L...SQGSKFRNIPN................................S...GLVMITRVFYWEQHF........................................................TNRLTVSLCVP.....AILLPVIPEAWGH.ITKWLDQCQNII....EVT.LDRYrst..............................................rdisMKDGLLPNDLN.....VYFPKECDSI..V........QLLQHKLIPCL......................................................................................................................................
A0A4P6XKE3_9ASCO/76-392              ..................RFRLLVSQDGGDLRAK---QVLYDSSKylvegvslrtksspatvspsaesfsdpgslrlgsssnsrlpnsaN----.-------Tlrsgssynk..............................vpiakqthnIN............DLNDYMFGR.GIPSVE..R...HTSTKIHVLLPlsl.........................lgdgS..gMAVLLSRVFLISAFGynadsdltgdldwvprptfkskdsvl....qihvptakhhcgssdhsqlqnrafsfSSRFAVGVVIPledsgETIEEVISSNWET.IAHFLIVLQKLI....CKK.LTLAlkaslinglspli...........................snkrivfplgvlqL----------.....----------..-........-----------epefghqlqkltklihynvntprlininafmthslnhmstnlntnvinw.....................................................................................
A0A512U9A5_9ASCO/88-407              ..................RFRLVVAQDGGNLRTK---QVLYDSANdisvaqpppwlkpgqsvasnt..gsalspvsssgsssppqspcsE----.-------Nsrlatstntlra.......................asstnlvakqshnIN............DINDYMFGR.GLPSVE..K...YTSTKIHMLPSlnss........................sngaS...SAVLLTKLFSISDSSlsagdtailpdsdwvpratfpsketa....fqisvpssksslsapdsalsprslsfSSRFSVGIIIPledanETVEEVLSSNWDT.LSHYLIVLQKIAs.kkI--.-IVAlkns............................................lvynsS----------.....----------..-........-----------pyiinkrisfpsgvlqsesefghqlqklvklvhynvntprlvninafmtyslnhmdsklktnvm......................................................................
C4QY02_KOMPG/75-300                  .................l-FRVVIFQDGRVLNTR---QVLFDSAV............................................KQQTSvQNGANKVKfnlnt......................................kmfhnYS............ELSEYMFGS.GVPIND..S...TNSIKLHILPDlpyh........................svhkV...KLVLITRLFSTTNRFdsnfgnhstsstnahdqe...................wvthptidlsikgrgkrsgATNFGIGLIIPis.leNCLNTVIGDNWEE.LTDYACHLQFTT....TNK.LQKIyn.................................................lqQ--LTDSKDKDsatpnFSSFVLQNDV.gL........HQLFQQLIK--lm....................................................................................................................................
A0A376B0V9_9ASCO/120-215             .................g-FRLLIACENGELMSRSNHKIIFDKTV............................................CSSVN.NNNNNNNNtsntinsntndn........................infnsnisklisQN............ELKEYIFGS.PVRCGN..-...-----------................................-...---------------........................................................-----------.....-------------.------------....---.----.....................................................-----------.....----------..-........-----------prsfasnqlncnlqt.......................................................................................................................
LST4_ASHGO/71-229                    ..................TFRLVVAQELGQMMSRDNYQVVLDCGG............................................TRAAV.GSGGAEMP................................................LS............ELKEYIFGS.PVRLSD..R...CRSDKLKLSRG................................A...RVIVVTRIFYTGYAG.......................................................nARRLAVCCCIP.....EQFLTVVTECWSQ.VSAWFDEVQDVL....MPL.LEAE.....................................................---PLLPKDLR.....VSAPAQVDVL..L........HKFYRHLIL--pl....................................................................................................................................
A0A1X7R0Y1_9SACH/216-403             .................p-FRILVAEETEQMACRSNFKLFLDHSY............................................PQ---.YSDIGKIR................................................PN............ELRQYMFCS.IFRVMN..SkkyNKNEKFRVIPN................................S...EYMILTRIFYLNSPY........................................................-NRIAINLCLP.....KFLLPIITEVWSF.IQNWWDESQRIL....TKI.ILEHkrnpsglkgkkplh.........................dtsdnntfnknttgNTTHSLQNIFL.....QKYSMEFERI..I........SILKNYLIPCF......................................................................................................................................
W6MV34_9ASCO/56-276                  .................l-FRLVIFQD-GGMRSK---HALFDSAVsvptqaipeg........................vsgsagsipvQ----.-------Pcqkftkl..................................dgnryhpQR............ELMTHMFGH.GVLVET..-...SNSVKIHVLPPlp............................amP...DSILLTRLVSVDSHYcaqkdpgatpndwhp.........................qatirscqrdapaangSTRFGIGVVVPi..stKDFDEVIADNWEE.VADELAALQDLL....LCK.LQASmars.............................................ktatS----------.....----------..-........-----------tsanapqgmrfapsslqndlelqtglls..........................................................................................................
A0A1L0BZN6_9ASCO/63-353              ..................RFRLLVCQDGGNLRSK---QVLYDSAAdlltsspvltpgvspa...........tsapvpcgtsdsqlsskV----.-------Aslsllrnssvvklnap................tqmgsknillskqlynVN............EINDYMFGR.GLPTNE..S...CTATKIHMLPQvnl.........................vygpY...LAILVTRLFLIVDPSssyaetnvssiydrswhpapavptke...affsysgnfcktpgtpaegsmasrssyHSRFAIGIVIPlesadQTAEDVLGSNLDA.IAHHLVILQKVV....LKK.LILClkystvngv..................................cpyinnrriqF----------.....----------..-........-----------pqnilrsdaelltqlnklvklfyfntn...........................................................................................................
A0A2V1AP52_9ASCO/61-360              ..................RFRLVVAQDGGNLRSK---QVLFDSADrqdsglgsapgsgph..............seapspsrprsqsdnK----.-------Snlqsptmstpaspkteddslqqs..lsnlsfsrgsasknilttkllhnAS............ELNEYMFGR.GLPSSE..S...HTATKVHLLPQfns.........................vhgsF...SAVLVTKLFSIPDNGgimgetshdtdpswsptptfpiretsy..sfpsslssnqassspespslgvskytvNSRFAIGIVIPys.qeQSVDEVVLQNWEV.LSQYLVSLQKLV....TKK.LLMV.....................................................-----------.....----------..-........-----------inystvngmcpyianrrisfpsellqadselprqlhklyrlihfn.........................................................................................
A0A1Q2YEG5_9ASCO/151-357             .................g-FRMVVIQDAG-IRKK---QPLFDSAV............................................PYNKN.FTIMQQKL................................................-Nkkih....hsinELSLFMFGCyGMPMSE..N...NMTTKMHYLPSls............................smH...SSVLVTRLFSLDSSFrlkphkmsassldwe.........................phplletdelplyensSIRFSIGLVIPvsssiESVRDEITENWLQ.TSDTLLTLQNLI....VAK.LKNI.....................................................YKSQNSPKKAQ.....SHF-------..-........-----------gqsnptycspnntihslsnks.................................................................................................................
M3HTS6_CANMX/84-346                  .................l-FRVIISQDGGNLRSK---QVLFDSANdvnspakpspq......................lqpnhsqnhqqN----.-------Qpplsdlsnlkks.......................tsksmviskiyhnMT............ELNDYMFGC.GLPSNE..N...QSTTKIHTLPPltns........................iygpY...PAILITRLFSISDAEfndipsllksknknewsphpal...........riketsirkisfkndennsknsvNSRFAIGIVIPlg.sfCYLQDVIFNNWQE.ITHFIIILQKLI....YKK.LLLN.....................................................-LNLKLNYDTN.....----------..-........-----------nnftgcqylvnkriqfpnyilqgdldinsqlfkli...................................................................................................
A0A1D8PGY3_CANAL/67-315              .................l-FRIIISQDGGNLRTK---QVLYDSANdesniyspt..........................ksqsysclmQ----.-------Hqqqqqqqqqtqdfsnf...............krpvspktmksgkiyhnMS............DLNDYMFGC.GLPSNE..N...HSATKLHVLPPltns........................myepY...PAVLITRLFSISDGEfidsslfsstetkewqpnpal.............vvkessirkvslkddtsknnnvNSRFAIGIVIPle.slGSLIDIVFNNWHE.IIHYTINLQKLI....YKK.LLVH.....................................................-LNQGLTYD-S.....THSYTGCQYL..I........-----------nkriqfpnf.............................................................................................................................
A0A1G4KBI5_9SACH/51-206              ..................QFRVLVAQDLGELMSRHSFQVALD--Y............................................CNAR-.GSAMDQIS................................................AN............ELRNYIFGS.AVRTID..P...HQSDKFRVLSD................................M...GVLLVMRVFPATGNG........................................................-QRLAMCLCLP.....ESYATALSEVWSY.VTRWLDECRELA....TTI.VASE.....................................................-SVKPLPRNIG.....VQASQSSEAI..I........SSVYKLLVPV-i.....................................................................................................................................
A0A1A0H9D2_9ASCO/54-318              ..................RFRLVVSQDGGNLRSK---QVLYDSAAdslisgnyas.......................pslssrlphsaT----.-------Tlrgaspgkn..............................vhmakflynVN............DLNDYMFGR.GLPSVE..R...HTSTKIHILPPlnll........................aqgsC...LAVLLTKLFLISDSTpgpgeldvlddsdwtphatfpskdtv...fhvslpsgkpcvttpdlpsltrttfllSSRFAVGVIVPledlsATVEEVIFSNWEI.ISHYLIVLQKLV....CKK.LTLAlks..............................................slafN----------.....----------..-........-----------qspyinnkrilfpsgvlqletefghqlqkliklvhynv................................................................................................
Q6BM05_DEBHA/90-359                  .................f-FRIIISQDGGNLRSK---QVLYDSAAqnndnp...............................gviarppPMSRN.NSSNNVNSknilt.....................................skiyhnAS............ELNDYMFGC.GLPSNE..T...YSTTKIHILPTlnns........................tygsN...QSILITRLFSISDNNdsqifnesfqshwmprpalpiketsi...kndafniahakannpdtgstskssnsiNSRFSIGLIIPlesvnDHLNDVIFNNWDV.ISHYILVLQKLI....IKK.LILT.....................................................LNNSVNDLSLS.....----------..-........-----------nlslqnnspnhthiycpyivnkriqfpsyilqneldlnnqlikl..........................................................................................
G8ZYV2_TORDC/103-269                 ..................AFRVLVAEETGHMMHRNHYNVVFD--Y............................................STAK-.SPSMDQIR................................................PN............ELKEYIFGS.PVRSSD..S...SQGNKFRTIPN................................S...ELVMVTRTFFFEART........................................................NNRLAVSLCVP.....HILLPVISEIWPN.ISRWFDQCQEIT....LSM.LRANllsr............................................hghrlSCEGYLPQNLK.....SVFPTECDSI..V........TLLRNNLIPCF......................................................................................................................................
LST4_CANGA/38-209                    ..................EYRLLILEENAEMVCRQRYRTILDYSSrghgs.................................mglkhdEMTNG.NVSAPFIT................................................AS............ELRQYIYGS.PIRSKT..R...VTEDKFRIIPN................................S...RQLLITRVFYPRRTSmnlhgtf..........................................pknyqssDRRVSITMCLP.....SYLLADISDSWAD.IDGWLTQTERHL....---.M---.....................................................--------ATS.....FHVVETQDNF..V........TLVNKLLIPAL......................................................................................................................................
H2AXH0_KAZAF/99-268                  .................c-FRVLIAEETGQIACKNHYRFSLDYSY............................................PQQN-.SGNLMKIR................................................QN............ELKQYIFGS.LVPSMS..N...LQNDKFRSIPN................................S...KFIIITRIFHANQGSng...................................................issKNRFAISLCIP.....NFLTPVIAEAWSF.INIWLDQSQNVIs.sqLNFlIKRN.....................................................QQGGILPMDYG....tSCYSKDIDKI..I........FSLTKNLLPCL......................................................................................................................................
G3BBE9_CANTC/60-295                  .................l-FRILVSQDGGSLRSK---QVLFDSAHe.........................................dkP----.LSAAPKSNltrsim...................................spkihhnPN............ELHDYMFGC.GLPTNE..L...HSITKIHMLPVssq..........................ygsS...RCVLVTRLFSITDFQdstispgspssnesqeigvwcprptl....pinttkisvhpsstasvsatstknnvTSRFAVGLIIPl...dDNVTEVIANNWHE.ICHFLIVLQKTVskkmIGV.INQN.....................................................-EHMPYIQNKR.....IQFP------..-........-----------syilandmdiqsnllklikli.................................................................................................................
A0A0C7NDN7_9SACH/52-207              ..................RFRVVIAQELGQLMSRQNYQVVFD--Y............................................VTAR-.GTAMDHIS................................................VT............EVKEYMFGS.PVRAKT..R...HKSEKFRVVAN................................A...GVLLVTRVFYAPHRD........................................................-TRLAICLSLP.....EPFLTALSEIWEH.VSRWLDECQDLL....LAI.LVNE.....................................................-DLTFLPRDLR.....VHDPQITQSI..I........QSLHTLVLPL-m.....................................................................................................................................
A0A367YLP4_9ASCO/86-339              .................l-FRIIISQDGGNLRSK---QVLFDSACdvpsp..................................dtkslQ----.-----QQHqqplqdlsnvkk.......................pskpmvtskvyhnVS............DLNDYMFGC.GLPSNE..N...QSTTKIHTLPPltns........................iygpY...SAVLITRLFSISDGEftelpnlpnqdanewqphpal.............rvkessirkvsikddstknnnvNSRFSIGVVIPle.siCSMPDVIFNNWHE.ITHFMILLQKLI....YKK.LLMH.....................................................-LNAGLNYDTN.....-NN-------..-........-----------ftgcqylikkriqfpnyilqgdyeinpqlvkliktv..................................................................................................
C5E178_ZYGRC/89-253                  .................i-FRILVAEETGRM-CRNNYKVVMD--F............................................STAK-.GQQMDQIR................................................PN............ELKEYIFGS.PIRSAD..L...SQGNKFRTIPN................................S...GLVLITRVFFTDDPS.......................................................wNNRLTVSLCVP.....TVLLPIIPEAWQH.ITRWLDQCQSIV....LDI.WSKSksv..............................................kcknYQDGVLPSNLN.....VHFRYECDTI..V........QLLQGKLIPCL......................................................................................................................................
G8Y7B9_PICSO/84-352                  .................f-FRIVVSQDGGSLRTK---QVLFDSSMlensq.................................gktagaS----.-------Qgpsssasrn..............................imtsklhhnIN............EINDYMFGC.GLPTNE..H...HCTTKLHILPAlnnq........................vygtN...RSILITRLFSISDNNdsmsfgdastdeywhphsslpirqvpf..kyggksgnqndspykdmyysdtktnniNSRFSIGLIIPlengdQDITETILTNWNE.ISYFMIVLQRLI....VKT.LISVlhrn.............................................asslI----------.....----------..-........-----------nestspynridqghsptsgspfiinkriqfpnyvlqnnpeihsqliklik....................................................................................
LST4_VANPO/102-271                   ..................SFRLLLTEETGQMVCRNNYRVVLD--Y............................................VTPK-.GSYIEQIR................................................PS............ELKEYIFGS.PVRSSD..S...LEVDKIRVIPN................................S...NILIISRTFHVSSKI........................................................-NRLAICLCLP.....SYYLPVVMEAWRQ.VSTWLDNTQASI....ISI.ISRLkkppst........................................lhlqcdkELSCLLPADAR.....FQFVSEFESI..I........LALQRKIVPCL......................................................................................................................................
A0A2H0ZMI6_CANAR/63-361              ..................RFRLVVSQDGGNLRSK---QVLFDSADrhdtpasgsgcqsrtp............spsrprssselrsassM----.-------Rsptspseesaeqlsqtlsml........qfsrasvaskniltskllhnVT............ELNEYMFGR.GLPSSE..S...HTATKVHLLPQfns.........................vhgsF...QAVLVTKLFSIPDTSgivpeqphdpdpcweptptfpvressysfpsslsagqassspesapsltvsnkytvNSRFALGIVIPfs.qeQSVDDVLFQNWEV.ISHYLVILQKLV....TKK.LLSVikystvngm..................................cpyianrrisF----------.....----------..-........-----------psellqadsdlsrqvqklfslvhyny............................................................................................................
A5DV88_LODEL/188-404                 ...........kgsphhs--------------------------Y............................................QQHN-.PHHHHHLQ................................................QNlphri..hhnvaDLNDLCFGC.GLPSNE..S...HTITKFHILPSplsn........................ssspY...NSVLITRLFSISDHDpmsnesllhnqdewlpk......................sstfvkdqniklndykiSSRFAIGIVIPie.ssHLIHEDIINNWNE.LSHFLTNLQKLI....YRK.LLQQlnlgf...........................................dnshhSC---------.....----------..-........-----------eylvkkrlqfpsfilqtdhdlhqllnkliklthylsntprl.............................................................................................
A0A1E4REB1_9ASCO/74-208              .................f-FRIIIAQDGGSLRSK---QVLYDSSS............................................SMDHN.QNPSSSWQlnsnpnqsspssknpk................snlsakniltskiyhnAS............ELNDYMFGC.GLPTNE..S...ASSTKMHILPTlnns........................iygsY...LSVLITKLFLIPSA-........................................................-----------.....-------------.------------....---.----.....................................................-----------.....----------..-........-----------tsetntsnpttnne........................................................................................................................
A3LN66_PICST/76-321                  .................f-FRILISQDGGSLRAK---QVLYDSAS............................................DSQSP.NASTPTSPtataynckpfcrpn....................slnrnimtskvyhnSS............ELNDYMFGC.GLPSNE..T...NCATKVHILPVltns........................vcgpY...NSVLVTRLFSISDFEaseqcsdlsrlsldsswnpsptir.......vgntnirkhlfakascnennnknnfNSRFAISVVIPle.siNDINDVIFNNWEE.ISHFMVVMQKIV....YKK.LIMH....................................................lNNDSFYDNDNK.....----------..-........-----------ltscpylinkriqfpsymlq..................................................................................................................
I2H1W9_TETBL/147-323                 .................g-FGVFIVEETAKRMSRCSYRIAME--Y............................................VSIK-.GTAIQKIR................................................PN............ELKEYIFGS.PIRLSN..S...TQTTKIRFIPT................................S...GLIMVTRLFYFEAGS........................................................-NRLAICFCVP.....KKYLVAICEVWKQ.VSLWFDRIQDII....INL.IKNRgannnyrsfv.................................lspcggnngdNSEILLPVDIR.....NQYPVEAERI..I........TCLKKMLIPNI......................................................................................................................................
A0A1G4MGZ6_LACFM/51-206              ..................QFRVVIAQEMGQIMSRHNYQIVLD--Y............................................VASR-.GSAMDQIS................................................LS............ELKDYIFGS.PVRAKN..R...NQSDKFRVVTS................................A...GVLLVIRAFYVSGGD........................................................-NRHAICLCLP.....DTFMTALSEVWSH.ISKWLDECQALL....ESS.LLRS.....................................................-GSSFLPRDLR.....LQDPQSADSI..V........QSIFKLLLPL-i.....................................................................................................................................
A0A642UPL2_DIURU/58-269              .................g-FRVVVAQDSGSIHYK---DVLFDSSR............................................RAPGQ.MSSAPTTLst............................................lsPSgpttlpslhsqaQLCKFMFGS.-FPSSE..T...QTTTKIHMLPPl..............................sSvhgAMVLISRVFSLDDDNsptttadadddddwv..........................vappmpgptssappvASRLALGLVIPme.vsTDITDVIFANWGV.VHHHLNQFQAMV....MAR.TAAI.....................................................---HPLPQTTR.....----------..-........-----------lrladycfqndsdffvlvkrfirsm.............................................................................................................
G8BU48_TETPH/134-344                 ..................SFRLIVAEETGQMASINNHRFIIDTTF............................................PK---.NSSMSHIR................................................NS............ELKEYIFGS.PLRLSE..S...TKSDKFRTIPN................................S...NMTLIIRSFTYSSKL........................................................SNKLAICLCVP.....TNYFPVITEGWSA.ISQWLDYTQKII....LVM.TKKGihqkhspcpvtikngainnpetrattgytfynnmsqellvnksvnspfknndaSSSSLLSIDAR.....FKNTPDVDKI..I........QKLQKVVMPCL......................................................................................................................................
I2JY10_DEKBR/1-195                   .................m---------------------------............................................-----.--------................................................-N............ELSTYMFGYyGILMSE..A...YXVTKMHYLPXfchrc.....................lirfxsX...ECFPWIPTFETTIPHndhaasdwdptp...............................censadypsxannSTRFGIGFVIPagndfRSVEEEITDNWKE.ISHHIILVQTAI....IKL.LKKNykpqt..........................................nrnhrtS----------.....----------..-........-----------knavygynscptvaagstlmtsrlsafpsyllqsnfelnhqfhslvrciqhlv.................................................................................
A0A2U9R4Z0_PICKU/131-346             ................ci--RMVIVQDAG-IRKK---QPLFDSAV............................................VFNKN.FSAMQQKL................................................NKkih.....hsinELSLFMFGSfGMPISE..N...NISTKIHYLPSlp............................gmP...SSILITRLFSIDASFvlkpsqtcqdisdwh.........................ptplirtnempqhentSIRFSIGLVIPtsssmESVRDEVTENWLE.FSKSFLDIQNLI....VIK.LKNL.....................................................---HFIQQRIK.....LKPIQQVQ--..-........-----------vsvnssvscmdnskldklnfqayclqsd..........................................................................................................
A0A1G4JBN0_9SACH/52-207              ..................RFRIVVAQELGQLMSRHNYQIVLD--Y............................................VTAR-.GSAMDHIS................................................VT............ELKEYIFGS.PVRAKT..R...LKSNKFRVVSN................................A...GVLLVTRIFYAPNCD........................................................-TRLAICLSLP.....EPFLTSLSEIWSQ.ISGWLDECQALL....LAV.LSNE.....................................................-QLPFLPRDLR.....SHDPQITQSI..V........HSIYTLVLPL-v.....................................................................................................................................
A0A4P9ZGX9_9ASCO/178-390             lsrtgmnrnvvlqkqshe---------------------------............................................-----.--------................................................IN............VVAEYMFGR.GLPSNE..W...HTATKIHILPPlkl.........................vhgtS...RAVLVTRLFLLVDTHvaqasdaekgdsacwkpqpt...............ihargstfsyssrslqlrtsvSSRFAIGIVVPfddpsQTVEETLLSNWDV.ISMQLVQIQKAV....ATK.LAAAlkngap........................................hpspyicN----------.....----------..-........-----------krvlfpphmlqgdvdlaahlqrlirivhyqtnvprlisth..............................................................................................
A0A7H9B4H4_ZYGMR/116-275             ..................AFRVLIVEEQAQMTNKNNYTVVLD--Y............................................STANE.STNYGQIR................................................PN............ELKEYIFGS.PVRSKE..S...LQENKFRTIPN................................S...ELVMITRIFHSPKSN........................................................-NRLAVSICVP.....MELLSIISEAWTQ.VSQWLDECQGIL....LGI.LRKRs...................................................kCNCYFLPNNMK.....ETHPKECQSV..I........SLLQRKLIPCL......................................................................................................................................
J5PI39_SACK1/118-288                 ..................AFRILIIEEAGQMACRNNYRDIFD--Y............................................TTSKV.SNSMEQIR................................................PS............ELKEYIFGS.PVRASD..L...TQCDKIRTIPN................................S...DLVLITRIFYYTHQY........................................................-NRIAISLCIP.....KILLPVVAESWSC.ISSWLTQTQKML....IGF.LNRNrimqen........................................tgnysnnSVIKLSNIDIK.....IHYPKEIEIM..V........QTLQKRVIPCL......................................................................................................................................
A0A1E3PBU9_WICAA/54-220              ..................SFRLVIIQDKGELLMKNNYKTHYDSAL............................................DPHFN.RPIHNKLS................................................NKhe........ssELVEIMFGN.PIHHDL.nR...SDNFKIHVMSSlp............................dlK...NSILVSMHFYFDKKH........................................................--KFAIGIVIPi..glNDISSVVLSNWVA.VSNHLNLLKAIF....---.----.....................................................IENHLNIKKCNn...tSTQMASSNYL.dI........SIFFKTFIKS-t.....................................................................................................................................
G0W357_NAUDC/144-324                 ..................AFRFLLTEETNEMACVNNYRILLDHNF............................................TKGE-.GSKIEQIR................................................HS............ELKEYIFGS.PVRSSD..Y...IQSDKFRSVPN................................S...DFTLITRIFYLNSIS........................................................-NRFAISLCIS.....KFLFPVISESWTY.ISHWLTDIQDII....ASI.VAENagtckgttnsn...............................nmeqftyqnrsISDGVLPVNLE.....IAFPDEIGKI..I........QVLAKKLMPCL......................................................................................................................................
A0A376B0V9_9ASCO/230-363             ...........ntlllqd---------------------------............................................-----.--------................................................--............---------.------..-...-SDDKLRVIKLp.............................gyE...PIILISRTFRINAAQspqi................................................nnngKSKISISILVS.....SRYTSSILESWNHgILFWFDCAQQRL....SNN.INYMnafnn..........................................pnyaaaTTTTNNNTNMK.....SQQYIMDNNIriL........NSFIKNFIPLL......................................................................................................................................
A0A421JFL0_9ASCO/72-302              ..................AFRVIVSQDGGNLRSK---QVLYDSAYn.........................................gtPIARN.QKSKLHHH................................................AA............ELHDYIFGC.GIPANE..S...HFSSKLHILPSphnk........................fsdtH...YSVLVSRLFSLTDLAdedsnstpswcpqsaldtdka.............tklyasvpafdykptskshnfiHSRFAVAFIVPie.slDNLTTVVFNNWEE.ICHFSIILQRLVs.kkLVT.LLNN.....................................................-----------.....----------..-........-----------avrdevsdcdaspyitnkriqfpdlvlqqdsdvalqlkklvrlvh.........................................................................................
G3AMR0_SPAPN/82-442                  .................l-FRIIISQDGGNLRSK---QVLYDSAVepqsp.................................tastptQ----.-------Pttmssscsnatlvsttk..............skplntrnittskvhhnVS............DLNDYMFGC.GLPSNE..T...HCNTKIHVLPQinns........................asapY...NAVLITRLFSISDLEvsewsplsslssqnnnwiptpalpi......kesnikkypfkngkdnstsktnnfiNSRFSIGLVVPle.svNSITDVIFNNWHE.ISHYLIILQKLV....YRK.LMIH.....................................................LNSGFN-----.....----------..-........-----------ydnesnitgcqflvnkriqfpnyilhgdfdinsqlykliksihynfnipklinsnylmktsvlneshqynpmlinwvleilnwlefkegkpttpnynynssflhsnslleyglqsstqnvntntflasllalli
A0A4V4NFE8_9ASCO/101-302             .................c-FRVVVIQDAGIR-KK---HPLFDSAI............................................PISKH.FPSMQHKL................................................NKtih.....hsvnELSLFMFGCyGMPISE..N...NVTTKMHYLPAla............................nmS...ASILVTRLFSIDSSFklkphrfsrttsewd.........................prpiletdelpinensSIRFSLGLIIPvsssiESVREEITELWPQ.MSESLRSMQDVV....CAC.LKHQyslq............................................nskkaQHQQFLQQNH-.....----------..-........-----------qqhlpsvyvsp...........................................................................................................................
A0A2P7YX11_9ASCO/60-343              ..................RFRLVVAQDGGNLRAK---QVLFDSADrqd......................................lgsN----.PSSAQHLEapspsrprsqdtstpaspsqdlsqtlsnllfsrnhsskniltskllhnVS............ELNEYMFGR.GLPSSE..T...HTATKVHLLPQfns.........................vhgsF...SAVLVTKLFLIPDTGgamgeslteedpswlpkptypikett...yafplsmatpassspdlpsmgvskytvNSRFAIGIVIPys.ldQSVDEVVLQNWEA.LSQYLVSLQKMV....TKK.LLM-.....................................................-----------.....----------..-........-----------likystvngmcpyianrrvsfpsellqadsdlprqlhklyrlihfn........................................................................................
G8JX27_ERECY/76-245                  ..................TFRLVVAQELGQMMSRDNYQVVLDCSCsrn.....................................atmgPLSCS.NGNVGQIP................................................LS............ELKEYIFGS.PVRISD..R...CQSDKIKLIKS................................A...RLIVVTRIFYNIHIPst...................................................igpPQRIAISCCIP.....ECFFTVLTECWSQ.VSKWFDDCQKLL....APL.LEAD.....................................................---ILLPKELK.....VSSPTHAESI..F........HKFYRNLIIP-l.....................................................................................................................................
A5DE16_PICGU/72-305                  ..................AFRVIVSQDGGNLRSK---QVLYDSAYn.........................................gtPIARN.QKSKLHHH................................................AA............ELHDYIFGC.GIPANE..S...HFSSKLHILPSphnk........................fndtQ...YSVLVSKLFSLTDLAdedtystpswrpqsaldtdka.............ntlhaslpsfdykptskshnliHSRFAVAFIIPie.slDNLTTVVLNNWEE.ICHFSIILQRLVs.kkLVT.LLNNavrd.............................................evsdC----------.....----------..-........-----------daspyitnkriqfpdlvlqqdsdvalqikklvrlvhynt...............................................................................................
G8BE00_CANPC/59-320                  .................y-FRIIVSQDGGNLRSK---EILFDSAY............................................ESIQQ.QQQQST-Splqspsrsqeqrr.....................tslkkqsnsriyhnTT............DLNDLSFGC.GLPTNE..V...QTITKLHTLPPisn.........................sstaY...HAVLITRLFSISDAEvftpnatfqqgsgdwep.....................ksatatresrvklhdlkmNSRFSIGVVIPle.caNFIHEDIINEWSE.ISHFLTLLQKLV....YRK.LLLQlnmvidn.......................................gngceylV----------.....----------..-........-----------kkrlqfpnyilqndfelhaqlgklvklihydnntprlintnyfmklnkts....................................................................................
K0KHI5_WICCF/66-237                  ..................KFRLFIIQDKGELMVKNNFKIYYDSNI............................................TTTNN.GTTTNKNK................................................IDyn........ifQFLEIMFGN.SIHHDF.qS...NETIKIHNLES................................L...QFTLISKHFNIKLSNq.....................................................kkNLKFAIGLIIPc..siDLISTTITPNWQT.IIHYLSIFQSIF....---.----.....................................................IKNHLLNYNNY.....LDISIFYKNF..I........KNLKNL-----iitprllpglnf..........................................................................................................................
C5M5S4_CANTT/84-343                  .................l-FRIIISQDGGNLRSK---QVLFDSASeltssdfks..........................snnqspsqqQ----.-------Qpvqdssnfkks.........................sktmmtskiyhnAS............QLNDFMFGC.GLPSNE..N...QSTTKIHTLPPlsns........................iygpY...SAVLITRLFSISDGEftelpslpnqnpnewqphpalr............vkessirkvsikdddttknnhvNSRFAIGVVIPle.slSSMHDVIFNNWHE.ITHFMILLQKLI....YKK.LLMH.....................................................LNSGL-NYDTN.....N---------..-........-----------nftgcqylikrriqfpnfilqgdfeinpqvmkliktvh................................................................................................
A0A1E3NPJ5_9ASCO/147-352             .................g-FRMVVIQDAG-IRKK---QPLFDSAV............................................PYNKN.FTIMQQKL................................................-Nkklh....hsinELSLFMFGCyGMPMSE..N...NMTTKMHYLPSls............................smH...SSVLLTRLFSLDSSFrlkphklsansldwe.........................phplletdelplyensSIRFSIGLIIPvsssiESVRDEITENWLQ.TSDILLTLQNLI....VEK.LKNN.....................................................YKSQNSSKKAQ.....SHF-------..-........-----------gqsnptycspnnnihslsnk..................................................................................................................
A0A1E5RH26_9ASCO/234-473             .................g-FRLLIASEKDSAIGMSNHDLMLDKTAtqdnttqwfhsygkn..............isikddkkesgeqdgH----.-------Entaqndnfkir..........................ssnnnistlisQK............ELKEYIFGS.PIRYLApkS...MGQKKTRLSAEfkshgnmqdnpaqdmllfdhntkfriiqiplyE...PLVLISTLSCLPTPS........................................................KTSISVSMLMS.....SRYLSSLLEGWNNgLYFWFKNVQHKLs.lkL-A.ISVP.....................................................STNTQFNTDLK....pQRFGMETEKI..F........TSFVQNFIPNL......................................................................................................................................
LST4_YEAST/118-288                   ..................AFRILIIEEAGQMACRNNYRDIFD--Y............................................TTSKI.SNSMEQIR................................................PS............ELKEYIFGS.PVRSSD..L...TQCDKIRTIPN................................S...DLVLITRIFYYTHQY........................................................-NRIAISLCIP.....RILLPVVAESWSS.ISSWLTQTQKML....IGF.LTKNrimqen........................................tgnysnnSVIKLSNIDIR.....THYPKEIEIM..V........QTLQKRVIPG-l.....................................................................................................................................
A0A7H9HMH8_9SACH/102-265             .................v-FRVLIAEETGHMTHRDNYNVVFD--Y............................................STAE-.SPRMDQIR................................................PN............ELKEYIFGS.PVRSTD..A...SQGSKFRTIPN................................S...DSVMITRIFFFSSVN........................................................KNRLAVSLCVP.....NILLQVISEVWDD.VSSWFDQCQAYI....LAT.IRGIrhs...............................................vssPYSGYLPPDFE.....SAYPKECDNI..V........NLLQTRLIPCL......................................................................................................................................
C4Y9S0_CLAL4/41-272                  ..................RFRLVVGQDTGNLRAK---QVLFDSDQ............................................SPTQN.GSAHISTMhnqahlenahghsvha................sssaslagsysgpkvsSS............EIADYMFGR.GIPTSE..S...APATKVHVLYS................................AqgrPALLVTKLFSLAGRPdsesapdwapap................................tfssrshtlpapSCRFSVGVVIPl...eQPPHILLSTLWPS.LAQHLAQLQNSV....SEK.LVAAlrsapngv....................................cyvrqrrivFPAHLLQQDID.....----------..-........-----------laqsvpclaravqatfnt....................................................................................................................
C5DKG7_LACTC/52-207                  ..................RFRVVVAQELGQMMSRHNYQVVLD--Y............................................ATSR-.GSGMNHIS................................................VS............DLKEYIFGS.PVRAKT..R...HKCDKFRVVAG................................A...GVVLVTRVFYPSQRD........................................................-TRLAICLSLP.....ESFLSALSEIWTH.IGRWLDECQALL....LAI.LSND.....................................................-SLVSLPRDLR.....AHDPQITESI..I........QSIHTLIVPL-v.....................................................................................................................................
A0A1E3QNV2_9ASCO/79-290              .................l-FRLVVCQDMGGLRKK---QVMCDSAA............................................TPARK.EESHPLTRplcsvrqsps............................ppltskihhpVR............ELMDYMFGC.GLPIHE..N...SDVTKFHVFPRaslhr.....................dasppsH...VCVLITRIFTLAGTNtaved..............................................flerqRIRVSIGLVVPld.afADINKTLAINWEE.IVASMDDLQSCVs.akLIA.V---.....................................................--LLANPTDLAa...pLSSPSTVNRL.qFplyslqydQDINFQFAKF-v.....................................................................................................................................
G0VAP5_NAUCC/150-320                 .................d-FRLLIAEETCQMACVNNYKISLD--Y............................................THSK-.NSSIEQIR................................................QN............ELKQYIFGS.PIRSSD.sS...IQNDKVRTIPN................................S...NFLLITRIFYLNSIS........................................................-NRLAITLCVS.....KFLLPVISEMWSQ.ISYSLNEIQNVV....LSM.ILKRntgdt..........................................enedesINDGLLPTNLDs...nLEFAKEIDFI..I........QLLNTKVMPCL......................................................................................................................................
LST4_KLULA/65-222                    .................g-FRLIISQELGHVTSRNNYQVVLDHSS............................................VN---.FHTGAHIP................................................LN............ELKDYIFGS.SIRTID.yS...ASSDKIKVVKS................................A...NIVLFTRIFYLNEKS........................................................TLRIAISCCVT.....DDVLPVLTECWPH.ISSFLDQCENTL....LKY.LAKN.....................................................-DTQFLPHDWK.....ARNCIEVAAV..L........QTFQRKIIPLL......................................................................................................................................
#=GR LST4_KLULA/65-222         SS    .................--EEEEEEEE---------EEEEEEEE-............................................TT---.--------................................................HH............HHHHHHC--.--SGGG.GS...SEEEEEEEEGG................................G...TEEEEEEEEESSTT-........................................................--EEEEEEEEE.....GGGHHHHHHTHHH.HHHHHHHHHHHH....HHH.HHHT.....................................................-T-S---SCCC.....CCC-HHHHHH..H........HHHHHTHHHHT......................................................................................................................................
J7S4B6_KAZNA/132-295                 ..................AFRLLLAEETGQMACRNNFRVSLD--Y............................................TFSR-.GSPLERIR................................................TS............ELKEYIFGS.MVRATE.sL...LENDKFRTIPN................................S...DFVLITRIFRFEDFP........................................................-NRFSISLCIP.....NSLFSVVSEIWQD.ITRWLTQTQTIV....LGY.LERKnsl...............................................kkhHEGAFLPLDYS.....AAFPKDVDKA..V........QSLQRKLLPCF......................................................................................................................................
A0A1E4RWV6_CYBJN/79-245              ..................SFRMVLVQDKGEIINRDNHKVLYDSSR............................................DHHFD.DPVAKKCD................................................YRhe........isELLDFMFGN.PIHQDF.hY...RGRVKLHVLSSlp............................glQ...KSVLLSTQFEHSKLN........................................................---FAIAVVIPv..nqEQLSQCIIPNWKQ.LIHHIALIKTSF....I--.----.....................................................-ENHVLQKQ--.....----QQGNYL.dI........AILFKQA----iislqnlvsipri.........................................................................................................................
A0A421JVB8_9ASCO/82-336              .................l-FRIIISQDGGNLRSK---QVLYDSAVesqspttlqvpqppatl.........sssstnsplvsskkpksfN----.-------Prnitt.....................................skmhhnVS............DLNDYMFGC.GLPSNE..T...HCNTKIHVLPQlnns........................acapY...SAILITRLFSISDLElsewsplstlasqsndwipspalpi.....kesnikkypfkngnenstsktnnnfiNSRFSIGLVIPle.svSSINDVIFNNWHE.ISHYLIILQKLV....YRK.LMIH.....................................................LNSGFN-----.....----------..-........-----------ydnesnitgcqflvnkriqfpnyilq............................................................................................................
W1QGG3_OGAPD/59-261                  ................lc--RLVVVQDSG-IRSK---QTLFDSALslrpg..................................vseasSP---.-------Aylnk.......................................sfhhpTS............ELSALMFGYyGILLNE..T...ISTTKLHYLPPla............................amP...ASMLVTRLFSVNSSFrlcesghgdpdwap...........................kpcvysrgapvcdeaPTRMGFGLIVPig.kdQNAHEILTNHWPE.IAGHLESTQKLI....VAK.L---.....................................................-----------.....----------..-........-----------rtlaslgrpcagpkpsfpagclqkepdlvhslhlf...................................................................................................
A0A1E4TPH7_PACTA/84-290              ................sc--RIVVYQD-GNIRSK---QPLFDSAIqftg...................................stilnQ----.-QQQQNINfk...........................................nlkMDnsry....hnlaELSDYIFGC.GVPINE..V...STSSKLQVLPSlp............................ntT...NSILITRLFSLNQTFsndmviennnrdldlenve..................kwlpnptlkignpsnsgknCTRFGIGIVLPi..npDLIETVVTDNWEE.YINFITSIETST....VRK.LKA-.....................................................-----------.....----------..-........-----------lcstnpkfcsniqscdsnkrsl................................................................................................................
#=GC SS_cons                         .................--EEEEEEEE---------EEEEEEEE-............................................TT---.--------................................................HH............HHHHHHC--.--SGGG.GS...SEEEEEEEEGG................................G...TEEEEEEEEESSTT-........................................................--EEEEEEEEE.....GGGHHHHHHTHHH.HHHHHHHHHHHH....HHH.HHHT.....................................................-T-S---SCCC.....CCC-HHHHHH..H........HHHHHTHHHHT......................................................................................................................................
#=GC seq_cons                        ...................FRllluQ-sGplts+...pVlaDpuh............................................s......t.h.php................................................ss............ELp-YhFGs.sl.ss-..s...ppssKl+hlPs................................t...sslLlTRlF.lsstp........................................................ssRhuIulllP.....pslhsllhpsWpp.IocaLsphQpll....hth.Lhtt.............................................................pht...........................................................................................................................................................................
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