#=GF ID   Lymphostatin_VX-II
#=GF AC   PF30616.1
#=GF DE   Lymphostatin, vertex domain II
#=GF AU   Andreeva A;0000-0002-0450-0091
#=GF SE   Andreeva A
#=GF GA   27.00 27.00;
#=GF TC   29.60 42.60;
#=GF NC   25.90 22.20;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 8 -Z 90746521 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   40562750
#=GF RT   Structure of lymphostatin, a large multi-functional virulence
#=GF RT   factor of  pathogenic Escherichia coli.
#=GF RA   Griessmann M, Rasmussen T, Flegler VJ, Kraft C, Schneider R,
#=GF RA   Hateley M, Spantzel L, Stevens MP, Borsch M, Bottcher B;
#=GF RL   Nat Commun. 2025;16:5389.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the second vertex domain of Lymphostatin.
#=GF CC   Lymphostatin is a key virulence factor of enteropathogenic and
#=GF CC   enterohaemorrhagic Escherichia coli, playing roles in bacterial
#=GF CC   colonisation of the gut and in the inhibition of lymphocyte
#=GF CC   proliferation and proinflammatory responses [1]. Lymphostatin is
#=GF CC   composed of six distinct domains which enable complex
#=GF CC   interactions with host cells. These domains include two
#=GF CC   glycosyltransferase domains, one PaToxP-like protease domain, an
#=GF CC   ADP-ribosyltransferase domain, a vertex domain and a delivery
#=GF CC   domain [1]. The vertex domain has a two domain architecture. It
#=GF CC   is involved in interactions with different regions of
#=GF CC   Lymphostatin.
#=GF SQ   8
#=GS A0A0H3JC22_ECO57/1726-1956  AC A0A0H3JC22.1
#=GS B7UP10_ECO27/2006-2232      AC B7UP10.1
#=GS A0A4S3ZXC5_9FLAO/1018-1242  AC A0A4S3ZXC5.1
#=GS D2TM86_CITRI/1906-2136      AC D2TM86.1
#=GS D0I9D8_GRIHO/2095-2321      AC D0I9D8.1
#=GS B7UI23_ECO27/1771-2001      AC B7UI23.1
#=GS D2TGY3_CITRI/1757-1987      AC D2TGY3.1
#=GS D2TQZ6_CITRI/1912-2142      AC D2TQZ6.1
A0A0H3JC22_ECO57/1726-1956             .................................lhsi----LSRQKEHVKNLLSGLLDEFSNKLRKQGLSlKTNVLSVNNFKESKiNSDTVEVTVTDLQGRLY.RVDIDTRVIGLTFK.EGINSLSEALE--H..MNIDAIMSVIGLVQYARMIKMNDNISAIDHAGAVSDIKNIVDKFLGG.ILTLTNNRVYNPGG.VSGASLEGFTSSGLEVCASRMGGTAGRYLSNVAKVIKLPLLDIGINIWSLYDSSLNHAKA.TTQI.EYISTAIDVSFSSI.
B7UP10_ECO27/2006-2232                 ....................................l-LSKLQIQEESVSGILSAIHQRISAKLRDINI-.--HKYKINSVNHNS.KGDSVKLSLYDLDKHKNiNFNIDTSDLNITLR.QGLDSLTEAID--E..MNIDGIMAIVGIIQYIKITSYGSYISAIDHADFMSDIKTVVEKVVGTsLIFMGVEKFGT--S.ISQIRLETMAAIKLSQVATKIGGVQGRILSKIANVIKFPVIDTALNLWSLGESIHRYTSE.KTGSlDKMLAEIDVAFAS-t
A0A4S3ZXC5_9FLAO/1018-1242             ilrsaeqiadafdrfsikldnlldnlglnlenykfkn---------------------------------.-------SNIKKLD.DHFYQTTLVHKKTGKEV.SLSLDCTEFERIVN.NHVNTLAEATEPAV..VLGGVGLGLMGLIRGATALRGGHGSS-YDIVSVALGGKQLADAILGT.VAMTIIEDSLAESGtIFTFSIEGTIANLCERTALQVGGIVGKLLTSISIFLKLPLIG--LNIWGLYEDVTYLNSS.E-GS.QRAVAISQLVIDSI.
D2TM86_CITRI/1906-2136                 ....................................s-QVRLQRQATRVKQQLAGVLETLQQRFQSVTRS.SGRHLSVEQIELTDvGSGRFSLQVRDGETLHP.-VSVEAPDVVSRFQ.KLSTMLSALPASGV..MDFDLGMSVVGIVQYARMLQQGQEDSTLARLNLAMDIKQLSEATLGS.MIQIAGNKFLNTEG.IQGFRLESAVAEGLRSAATRTGGTMGKALSASARVLELPVLETALGTWNLYNSVTQLQQA.TRHS.DIMAARVQVAFDSL.
D0I9D8_GRIHO/2095-2321                 ...................................la--RRLQAQSERVGQLISDIYRNIKFKIDELGF-.--KKFKLGALNFND.NNDKIQLLLEDLDAKKS.-VNVDID--ISDFKmTLREGLDALS-EGVdrMNLDGIMSLLGIMQYVRLTQSGDHISAVDHANLGSDVKTVAEKVVGS.TLIFMGKKNFGSN-.ISDITFEAIAAQKVSQLATKIGGPTGKVLSRFANVIRFPLLDTALNLWSLGESVQNYLNAgDGSA.EKVLAEVDVAFAS-t
B7UI23_ECO27/1771-2001                 ....................................s-QTRLQRQATRVKQQLAGVLDTLQQHFQNIPRS.SGRHLSVENIELADiGSGRFNLQIRDGETLHT.-TSVEVPEVVSRFQ.KLSTMLSALPASGI..MDFDLGMSVVGVVQYARLLQQGHEDSTLAKINLAMDIKQLSEATLGS.MIQIAGNKFLNTEG.IQGFRLESAVAEGMRSVATRTGGTMGKALSASARVLELPVLETVLGTWNLYNSVIQLQQA.TSYS.ETMAARVQIAFDSI.
D2TGY3_CITRI/1757-1987                 ....................................s-QVRLQRQATRVKQQLAGVLETLQQRFQSVTRS.SGRHLSVEQIELTDvGSGRFSLQVRDGETLHP.-VSVEAPDVVSRFQ.KLSTMLSALPASGV..MDFDLGMSVVGIVQYARMLQQGQEDSTLARLNLAMDIKQLSEATLGS.MIQIAGNKFLNTEG.IQGFRLESAVAEGLRSAATRTGGTMGKALSASARVLELPVLETALGTWNLYNSVTQLQQA.TRHS.DIMAARVQVAFDSL.
D2TQZ6_CITRI/1912-2142                 ....................................s-QVRLQRQATRVKQQLAGVLETLQQRFQSVTRS.SGRHLSVEQIELTDvGSGRFSLQVRDGETLHP.-VSVEAPDVVSRFQ.KLSTMLSALPASGV..MDFDLGMSVVGIVQYARMLQQGQEDSTLARLNLAMDIKQLSEATLGS.MIQIAGNKFLNTEG.IQGFRLESAVAEGLRSAATRTGGTMGKALSASARVLELPVLETALGTWNLYNSVTQLQQA.TRHS.DIMAARVQVAFDSL.
#=GC seq_cons                          ....................................u..sRLQRQupRVKQ.LuGlL-slpp+hpslshS.ps++LSVpsIchsDlsSs+hsLpV+Dt-sh+s..VSV-ss-llScFp.cLsshLSALsssGV..MshDlGMSVVGIVQYARhLQpGpcsSsls+lNLAhDIKQLuEAsLGS.hIpluGNKFLNopG.IpGFRLEoslApGLcssATRsGGThGKsLSusA+VLcLPVL-TALshWsLYsSVppLppA.TppS.-hMuAcVQVAFDSl.
//