#=GF ID   M2AP_beta_dom
#=GF AC   PF21932.3
#=GF DE   MIC2-associated protein, central beta-domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   ECOD:EF19056
#=GF GA   27.00 27.00;
#=GF TC   31.90 130.10;
#=GF NC   23.70 19.70;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 81514348 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0004
#=GF RN   [1]
#=GF RM   25411252
#=GF RT   Structural basis of Toxoplasma gondii MIC2-associated protein
#=GF RT   interaction with  MIC2.
#=GF RA   Huynh MH, Liu B, Henry M, Liew L, Matthews SJ, Carruthers VB;
#=GF RL   J Biol Chem. 2015;290:1432-1441.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in MIC2-associated protein from Toxoplasma
#=GF CC   gondii (M2AP), which is necessary for the proper trafficking and
#=GF CC   secretion of MIC2 and thus involved in parasite invasion. M2AP
#=GF CC   is a soluble protein with an N-terminal propeptide, a central
#=GF CC   beta-domain (this entry), and a predicted C-terminal coil
#=GF CC   domain. This domain folds into a a compact beta-sandwich
#=GF CC   comprising 13 antiparallel beta-strands [1].
#=GF SQ   4
#=GS A0A2C6KKQ0_9APIC/49-223  AC A0A2C6KKQ0.1
#=GS A0A2A9MIN4_9APIC/50-215  AC A0A2A9MIN4.1
#=GS F0VL19_NEOCL/50-218      AC F0VL19.1
#=GS B9QN70_TOXGV/49-217      AC B9QN70.1
A0A2C6KKQ0_9APIC/49-223             vd--VKKVPCETIQLKTAMTENSFVRMSGAGWSEGPLNFQVSEQMtSEKEDKGQKQLYGISCYPTdDSETAEEDKKGKCFSTDFTNTTMNEKgeavPEVKEIDLPINSREDAFMFVCTT-TGRKLICDVYAYDNRG-TEGWKSRTIEADLKkE.SSHLGFRVQGSGVTAPKAYVTT----dvsf
A0A2A9MIN4_9APIC/50-215             .m-SLTEVDCDTVKVEGPLPEGAVVKLTASGWGAGPLQMDVGQALaDQNGDKGHSSVASITCHGP.DA--VESDQARKCYRTKVGAEGAV--....-EEEQVSLPITGPGSAFMFVCVSTGQAGLKCDVYGYDNAA-NDGWKVNSLEIPLP.AdAENLSFRLQATDLHTRKAYVSEDLK-v...
F0VL19_NEOCL/50-218                 ..LELVTVPCDAVHVQGTMGANDLVKITGAGWGSGALQFQVSHPV.KTGGDKSRSQLASVTCYSS.DATDAPEGKAGKCFLTKPAEDGSSDE....PQETEVSLPITSHNNAFMFVCSASTAPGVQCDVYAFDNVA-NNGWSVKTLDLGLS.T.STDLGFSVHAEALNTMKAYASSSLTV....
B9QN70_TOXGV/49-217                 ..LELVEVPCNSVHVQGVMTPNQMVKVTGAGWDNGVLEFYVTRPT.KTGGDTSRSHLASIMCYSK.DIDGVPSDKAGKCFLKNFSGEDSS-E....IDEKEVSLPIKSHNDAFMFVCSSNDGSALQCDVFALDNTNSSDGWKVNTVDLGVS.V.SPDLAFGLTADGVKVKKLYASSGLTA....
#=GC seq_cons                       ...pLscVPC-oV+VpGsMstNshVKlTGAGWusGsLpFpVocsh.cpsGDKu+SpLASIoCYus.Dupss.pDKAGKCFhTchus-sus.c.....-EcEVSLPIsS+ssAFMFVCoossusuLpCDVYAaDNsu.s-GWKVpTl-lsLs.s.SscLuFplpAsulpshKAYsSosLp.....
//