#=GF ID MAM
#=GF AC PF00629.26
#=GF DE MAM domain, meprin/A5/mu
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Prosite
#=GF GA 26.40 26.40;
#=GF TC 26.40 26.40;
#=GF NC 26.30 26.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK MAM_domain
#=GF CL CL0004
#=GF RN [1]
#=GF RM 8387703
#=GF RT An adhesive domain detected in functionally diverse receptors.
#=GF RA Beckmann G, Bork P;
#=GF RL Trends Biochem Sci. 1993;18:40-41.
#=GF RN [2]
#=GF RM 17761881
#=GF RT Structure of a tyrosine phosphatase adhesive interaction reveals
#=GF RT a spacer-clamp mechanism.
#=GF RA Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ,
#=GF RA van der Merwe PA, Jones EY;
#=GF RL Science. 2007;317:1217-1220.
#=GF RN [3]
#=GF RM 16456543
#=GF RT Molecular analysis of receptor protein tyrosine phosphatase
#=GF RT mu-mediated cell adhesion.
#=GF RA Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones
#=GF RA EY;
#=GF RL EMBO J. 2006;25:701-712.
#=GF RN [4]
#=GF RM 22988105
#=GF RT Structural basis for the sheddase function of human meprin beta
#=GF RT metalloproteinase at the plasma membrane.
#=GF RA Arolas JL, Broder C, Jefferson T, Guevara T, Sterchi EE, Bode W,
#=GF RA Stocker W, Becker-Pauly C, Gomis-Ruth FX;
#=GF RL Proc Natl Acad Sci U S A. 2012;109:16131-16136.
#=GF DR INTERPRO; IPR000998;
#=GF DR PROSITE_PROFILE; PS50144;
#=GF DR PROSITE; PDOC00604;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC An extracellular domain found in many receptors [1]. The MAM
#=GF CC domain along with the associated Ig domain in type IIB receptor
#=GF CC protein tyrosine phosphatases forms a structural unit (termed
#=GF CC MIg) with a seamless interdomain interface. It plays a major
#=GF CC role in homodimerisation of the phosphatase ectoprotein and in
#=GF CC cell adhesion [2,3]. MAM is a beta-sandwich consisting of two
#=GF CC five-stranded antiparallel beta-sheets rotated away from each
#=GF CC other by approx 25 degrees, and plays a similar role in meprin
#=GF CC metalloproteinases [4].
#=GF SQ 21129
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#=GS A0A1S3II16_LINUN/203-360 AC A0A1S3II16.1
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#=GS A0A3Q3EIV9_9LABR/595-761 AC A0A3Q3EIV9.1
#=GS A0A3M6V628_POCDA/1-89 AC A0A3M6V628.1
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#=GS A0A4Z2IEA0_9TELE/1-116 AC A0A4Z2IEA0.1
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#=GS A0A2A3EDN6_APICC/352-515 AC A0A2A3EDN6.1
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#=GS G3PLL9_GASAC/672-826 AC G3PLL9.1
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#=GS A0A087TZA6_STEMI/2058-2218 AC A0A087TZA6.1
#=GS A0A3P9N1M6_POERE/718-788 AC A0A3P9N1M6.1
#=GS A0A2P4SGV3_BAMTH/559-710 AC A0A2P4SGV3.1
#=GS A0A6P4XP00_BRABE/693-849 AC A0A6P4XP00.1
#=GS A0A4W5JS77_9TELE/19-145 AC A0A4W5JS77.1
#=GS A0A3M7PGF9_BRAPC/178-325 AC A0A3M7PGF9.1
#=GS A0A226PYA5_COLVI/114-273 AC A0A226PYA5.1
#=GS A0A3Q1BLU6_AMPOC/47-208 AC A0A3Q1BLU6.1
#=GS A0A673VFY0_SURSU/66-223 AC A0A673VFY0.1
#=GS A0A4W2DP36_BOBOX/27-183 AC A0A4W2DP36.1
#=GS MEP1B_HUMAN/265-428 AC Q16820.3
#=GS MEP1B_HUMAN/265-428 DR PDB; 7AUW C; 265-428;
#=GS MEP1B_HUMAN/265-428 DR PDB; 4GWM A; 265-428;
#=GS MEP1B_HUMAN/265-428 DR PDB; 7AUW A; 265-428;
#=GS MEP1B_HUMAN/265-428 DR PDB; 4GWN A; 265-428;
#=GS MEP1B_HUMAN/265-428 DR PDB; 4GWM B; 265-428;
#=GS A0A4W6C1F7_LATCA/445-586 AC A0A4W6C1F7.1
#=GS A0A6P5AWW7_BRABE/39-191 AC A0A6P5AWW7.1
#=GS A0A3M6ULK0_POCDA/969-1118 AC A0A3M6ULK0.1
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#=GS G8R2Q0_OWEHD/51-212 AC G8R2Q0.1
#=GS A0A6J1W4K7_9SAUR/9-167 AC A0A6J1W4K7.1
#=GS A0A2T7PKQ6_POMCA/4107-4267 AC A0A2T7PKQ6.1
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#=GS H0YW58_TAEGU/560-711 AC H0YW58.2
#=GS I3KTZ6_ORENI/451-609 AC I3KTZ6.2
#=GS A0A1Q9F7G0_SYMMI/536-688 AC A0A1Q9F7G0.1
#=GS A0A2K6NTY9_RHIRO/342-497 AC A0A2K6NTY9.1
#=GS I3K2K6_ORENI/612-768 AC I3K2K6.2
#=GS A0A3Q2FRF9_CYPVA/288-449 AC A0A3Q2FRF9.1
#=GS A0A674ELF3_SALTR/26-185 AC A0A674ELF3.1
#=GS A0A6Q2XGM0_ESOLU/711-884 AC A0A6Q2XGM0.1
#=GS K7G2G4_PELSI/306-462 AC K7G2G4.1
#=GS U3JPE0_FICAL/393-536 AC U3JPE0.1
#=GS A0A6J0W1S6_ODOVR/381-543 AC A0A6J0W1S6.1
#=GS A0A2K6V443_SAIBB/890-1054 AC A0A2K6V443.1
#=GS A0A671QQA1_9TELE/614-755 AC A0A671QQA1.1
#=GS G3HAF0_CRIGR/844-1005 AC G3HAF0.1
#=GS A0A5C6NDZ3_9TELE/700-845 AC A0A5C6NDZ3.1
#=GS H2QXC3_PANTR/26-168 AC H2QXC3.1
#=GS A0A443S8G0_9ACAR/841-1008 AC A0A443S8G0.1
#=GS A0A3R7P772_PENVA/994-1156 AC A0A3R7P772.1
#=GS A0A0V1LHI3_9BILA/117-253 AC A0A0V1LHI3.1
#=GS A0A671XKC4_SPAAU/376-530 AC A0A671XKC4.1
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#=GS A0A6J2KPC0_BOMMA/143-318 AC A0A6J2KPC0.1
#=GS F1PUN5_CANLF/1-121 AC F1PUN5.3
#=GS A0A2R9A5N9_PANPA/329-485 AC A0A2R9A5N9.1
#=GS A0A2K6NY01_RHIRO/66-229 AC A0A2K6NY01.1
#=GS A0A556TUD0_BAGYA/55-219 AC A0A556TUD0.1
#=GS A0A6P8FVD4_CLUHA/226-393 AC A0A6P8FVD4.1
#=GS A0A3Q1EGZ7_9TELE/31-166 AC A0A3Q1EGZ7.1
#=GS G3RYJ7_GORGO/753-917 AC G3RYJ7.1
#=GS A0A2R2MU23_LINUN/362-517 AC A0A2R2MU23.1
#=GS A0A7N6BE83_ANATE/7-127 AC A0A7N6BE83.1
#=GS A0A4X2KE02_VOMUR/874-1040 AC A0A4X2KE02.1
#=GS A0A6L2PDW9_COPFO/269-443 AC A0A6L2PDW9.1
#=GS A0A6P8SWX5_GYMAC/386-543 AC A0A6P8SWX5.1
#=GS A0A674E3U7_SALTR/38-197 AC A0A674E3U7.1
#=GS A0A6P8IV49_ACTTE/1396-1539 AC A0A6P8IV49.1
#=GS M3ZLG6_XIPMA/637-783 AC M3ZLG6.2
#=GS A0A2I4BCB8_9TELE/759-932 AC A0A2I4BCB8.1
#=GS H2Y4Y1_CIOSA/1-106 AC H2Y4Y1.1
#=GS A0A3M7T1H3_BRAPC/310-465 AC A0A3M7T1H3.1
#=GS A0A6J3RHU1_TURTR/63-205 AC A0A6J3RHU1.1
#=GS A0A663DRA6_AQUCH/787-959 AC A0A663DRA6.1
#=GS A0A091KZC1_9GRUI/222-385 AC A0A091KZC1.1
#=GS U3J8V5_ANAPP/470-622 AC U3J8V5.2
#=GS A0A673UPT8_SURSU/27-187 AC A0A673UPT8.1
#=GS A0A3P9NYV2_POERE/15-172 AC A0A3P9NYV2.1
#=GS A0A665XEG1_ECHNA/645-777 AC A0A665XEG1.1
#=GS A0A2Y9IUT8_ENHLU/1-116 AC A0A2Y9IUT8.1
#=GS A0A2U3W3L5_ODORO/347-503 AC A0A2U3W3L5.1
#=GS A0A091HA53_BUCRH/4-147 AC A0A091HA53.1
#=GS T1KD73_TETUR/880-1051 AC T1KD73.1
#=GS A0A315VT42_GAMAF/161-324 AC A0A315VT42.1
#=GS A0A401RNZ2_CHIPU/295-457 AC A0A401RNZ2.1
#=GS A0A0V1DDX0_TRIBR/301-464 AC A0A0V1DDX0.1
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#=GS A0A4W2E5C3_BOBOX/1040-1205 AC A0A4W2E5C3.1
#=GS A0A6I8NLA4_ORNAN/37-194 AC A0A6I8NLA4.1
#=GS A0A674MY73_TAKRU/614-781 AC A0A674MY73.1
#=GS A0A6H5INV0_9HYME/61-214 AC A0A6H5INV0.1
#=GS A0A673ZB07_SALTR/27-186 AC A0A673ZB07.1
#=GS A0A672GG94_SALFA/508-665 AC A0A672GG94.1
#=GS A0A0P7ULW4_SCLFO/159-315 AC A0A0P7ULW4.1
#=GS D3Z8B8_RAT/374-508 AC D3Z8B8.3
#=GS M3YC48_MUSPF/449-589 AC M3YC48.1
#=GS A0A6P6PTX4_CARAU/930-1086 AC A0A6P6PTX4.1
#=GS A0A6I9K3B8_CHRAS/1-122 AC A0A6I9K3B8.1
#=GS A0A6J1UX97_9SAUR/726-887 AC A0A6J1UX97.1
#=GS A0A0V0TYK5_9BILA/114-250 AC A0A0V0TYK5.1
#=GS A0A6P5AW44_BRABE/417-469 AC A0A6P5AW44.1
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#=GS A0A6J0Y7G0_ODOVR/604-760 AC A0A6J0Y7G0.1
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#=GS A0A663LR79_ATHCN/29-188 AC A0A663LR79.1
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#=GS A0A2Y9H528_NEOSC/484-570 AC A0A2Y9H528.1
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#=GS A0A091EHA1_CORBR/384-527 AC A0A091EHA1.1
#=GS A0A6P3GHP7_BISBI/72-227 AC A0A6P3GHP7.1
#=GS A0A671ECD4_RHIFE/1089-1254 AC A0A671ECD4.1
#=GS A0A6N6M913_9FLAO/341-502 AC A0A6N6M913.1
#=GS M7NBE2_9FLAO/862-1039 AC M7NBE2.1
#=GS A0A1S3IDH9_LINUN/160-317 AC A0A1S3IDH9.1
#=GS A0A3P9NA49_POERE/202-360 AC A0A3P9NA49.1
#=GS A0A6P7MDR8_BETSP/711-881 AC A0A6P7MDR8.1
#=GS G3NIT5_GASAC/813-966 AC G3NIT5.1
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#=GS A0A4W6DS88_LATCA/24-182 AC A0A4W6DS88.1
#=GS A0A6Q2Z5S6_ESOLU/13-124 AC A0A6Q2Z5S6.1
#=GS A0A3Q3X1I5_MOLML/474-629 AC A0A3Q3X1I5.1
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#=GS A0A6J8CFS3_MYTCO/1317-1469 AC A0A6J8CFS3.1
#=GS A0A1D1V3A8_RAMVA/225-404 AC A0A1D1V3A8.1
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#=GS A0A4W2CLA1_BOBOX/35-192 AC A0A4W2CLA1.1
#=GS A0A7N5JFX3_AILME/444-587 AC A0A7N5JFX3.1
#=GS G3VX37_SARHA/969-1135 AC G3VX37.2
#=GS A0A087TZA5_STEMI/1071-1230 AC A0A087TZA5.1
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#=GS A0A2K5JXI1_COLAP/646-801 AC A0A2K5JXI1.1
#=GS A0A4W4FRJ6_ELEEL/29-164 AC A0A4W4FRJ6.1
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