GenomeNet

Database: Pfam
Entry: MSL1_dimer
LinkDB: MSL1_dimer
Original site: MSL1_dimer 
#=GF ID   MSL1_dimer
#=GF AC   PF16801.7
#=GF DE   Dimerisation domain of Male-specific-Lethal 1
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_4b7y_A
#=GF GA   25.00 25.00;
#=GF TC   26.00 27.30;
#=GF NC   21.90 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Coiled-coil
#=GF RN   [1]
#=GF RM   23084835
#=GF RT   Msl1-mediated dimerization of the dosage compensation complex is
#=GF RT   essential for male X-chromosome regulation in Drosophila.
#=GF RA   Hallacli E, Lipp M, Georgiev P, Spielman C, Cusack S, Akhtar A,
#=GF RA   Kadlec J;
#=GF RL   Mol Cell. 2012;48:587-600.
#=GF DR   INTERPRO; IPR031840;
#=GF DR   SO; 0001080; coiled_coil;
#=GF CC   MSL1_dimer is the short coiled dimerisation domain of higher
#=GF CC   eukaryotic MSL1, part of the MSL or Male-Specific Lethal
#=GF CC   complex. This complex regulates the dosage compensation of the
#=GF CC   male X chromosome in Drosophila and other eukaryotes. The
#=GF CC   structure of the MSL1/MSL2 core shows that two MSL2 subunits
#=GF CC   bind to a dimer formed by two molecules of MSL1. MSL11 is a
#=GF CC   substrate for MSL2 E3 ubiquitin ligase activity [1].
#=GF SQ   246
#=GS W5PUD7_SHEEP/214-250      AC W5PUD7.1
#=GS A0A0P7WBD1_SCLFO/35-71    AC A0A0P7WBD1.1
#=GS A0A2I4BR59_9TELE/159-195  AC A0A2I4BR59.1
#=GS A0A3Q2KMS5_HORSE/214-250  AC A0A3Q2KMS5.1
#=GS A0A3Q3LKB3_9TELE/165-201  AC A0A3Q3LKB3.1
#=GS A0A4W4E8R2_ELEEL/176-212  AC A0A4W4E8R2.1
#=GS A0A2K6KY83_RHIBE/213-249  AC A0A2K6KY83.1
#=GS A0A5N5MKC4_PANHP/174-210  AC A0A5N5MKC4.1
#=GS A0A484GX81_SOUCH/214-250  AC A0A484GX81.1
#=GS A0A674CUD7_SALTR/178-213  AC A0A674CUD7.1
#=GS A0A5G2QBE7_PIG/214-250    AC A0A5G2QBE7.1
#=GS A0A1S3GYW2_DIPOR/214-250  AC A0A1S3GYW2.1
#=GS H3CXK1_TETNG/47-82        AC H3CXK1.1
#=GS J3KSZ8_HUMAN/214-250      AC J3KSZ8.1
#=GS A0A060W9B7_ONCMY/178-213  AC A0A060W9B7.1
#=GS A0A2K5IPU9_COLAP/13-49    AC A0A2K5IPU9.1
#=GS F1Q247_CANLF/214-250      AC F1Q247.2
#=GS A0A3Q3VZF4_MOLML/97-132   AC A0A3Q3VZF4.1
#=GS F1RXC8_PIG/214-250        AC F1RXC8.1
#=GS A0A671FFZ8_RHIFE/214-250  AC A0A671FFZ8.1
#=GS A0A452RJW2_URSAM/214-250  AC A0A452RJW2.1
#=GS MSL1_HUMAN/214-250        AC Q68DK7.3
#=GS MSL1_HUMAN/214-250        DR PDB; 4B86 I; 216-250;
#=GS MSL1_HUMAN/214-250        DR PDB; 4B86 E; 214-250;
#=GS MSL1_HUMAN/214-250        DR PDB; 4B86 A; 214-250;
#=GS MSL1_HUMAN/214-250        DR PDB; 4B86 F; 214-250;
#=GS MSL1_HUMAN/214-250        DR PDB; 4B86 J; 216-248;
#=GS MSL1_HUMAN/214-250        DR PDB; 4B86 B; 214-250;
#=GS MSL1_HUMAN/214-250        DR PDB; 4B7Y A; 214-250;
#=GS MSL1_HUMAN/214-250        DR PDB; 4B7Y B; 214-250;
#=GS A0A674CUD9_SALTR/178-213  AC A0A674CUD9.1
#=GS A0A1U7QW90_MESAU/214-250  AC A0A1U7QW90.1
#=GS A0A4W5PXR5_9TELE/178-213  AC A0A4W5PXR5.1
#=GS A0A5A9PSF0_9TELE/173-209  AC A0A5A9PSF0.1
#=GS A0A5F9D1E0_RABIT/213-249  AC A0A5F9D1E0.1
#=GS A0A2I2ZR52_GORGO/201-237  AC A0A2I2ZR52.1
#=GS A0A5C6PUB7_9TELE/52-87    AC A0A5C6PUB7.1
#=GS A0A673Y1M1_SALTR/179-214  AC A0A673Y1M1.1
#=GS A0A2R8N2Y4_CALJA/214-250  AC A0A2R8N2Y4.1
#=GS A0A3N0XEK4_ANAGA/165-201  AC A0A3N0XEK4.1
#=GS A0A4Z2GDG0_9TELE/143-178  AC A0A4Z2GDG0.1
#=GS A0A5E4AD56_MARMO/214-250  AC A0A5E4AD56.1
#=GS A0A672Y7U4_9TELE/99-134   AC A0A672Y7U4.1
#=GS A0A672TGX9_STRHB/150-185  AC A0A672TGX9.1
#=GS A0A673VN88_SALTR/184-220  AC A0A673VN88.1
#=GS A0A3P8YEU2_ESOLU/182-218  AC A0A3P8YEU2.1
#=GS A0A3Q2CW98_CYPVA/157-192  AC A0A3Q2CW98.1
#=GS A0A3Q7XYS5_URSAR/214-250  AC A0A3Q7XYS5.1
#=GS V8NTH3_OPHHA/70-106       AC V8NTH3.1
#=GS A0A5N3WZN1_MUNRE/214-250  AC A0A5N3WZN1.1
#=GS I3NFZ7_ICTTR/214-250      AC I3NFZ7.1
#=GS A0A673Y1G2_SALTR/179-214  AC A0A673Y1G2.1
#=GS A0A671WU51_SPAAU/166-201  AC A0A671WU51.1
#=GS A0A3S2MIL9_ORYJA/184-219  AC A0A3S2MIL9.1
#=GS A0A2K6QDK0_RHIRO/212-248  AC A0A2K6QDK0.1
#=GS A0A4X2KCD9_VOMUR/209-245  AC A0A4X2KCD9.1
#=GS A0A2K5V395_MACFA/212-248  AC A0A2K5V395.1
#=GS A0A2Y9FXB1_TRIMA/214-250  AC A0A2Y9FXB1.1
#=GS A0A2U4BNW9_TURTR/214-250  AC A0A2U4BNW9.1
#=GS A0A452EFJ7_CAPHI/214-250  AC A0A452EFJ7.1
#=GS A0A2U3YR88_LEPWE/214-250  AC A0A2U3YR88.1
#=GS M3YTY4_MUSPF/214-250      AC M3YTY4.1
#=GS A0A383ZR99_BALAS/214-250  AC A0A383ZR99.1
#=GS A0A485P8A5_LYNPA/13-49    AC A0A485P8A5.1
#=GS A0A2Y9IEQ1_NEOSC/214-250  AC A0A2Y9IEQ1.1
#=GS A0A674DST8_SALTR/184-220  AC A0A674DST8.1
#=GS A0A060W4K4_ONCMY/179-214  AC A0A060W4K4.1
#=GS A0A1A6HKC4_NEOLE/214-250  AC A0A1A6HKC4.1
#=GS G3NIS3_GASAC/47-82        AC G3NIS3.1
#=GS A0A2R8QEA0_DANRE/158-193  AC A0A2R8QEA0.1
#=GS A0A060WK02_ONCMY/56-92    AC A0A060WK02.1
#=GS A0A0D9S335_CHLSB/212-248  AC A0A0D9S335.1
#=GS A0A5A9NC38_9TELE/134-170  AC A0A5A9NC38.1
#=GS A0A674CV82_SALTR/178-213  AC A0A674CV82.1
#=GS A0A060X332_ONCMY/23-59    AC A0A060X332.1
#=GS A0A673Y1I6_SALTR/179-214  AC A0A673Y1I6.1
#=GS H2RA36_PANTR/214-250      AC H2RA36.2
#=GS A0A6Q2XL14_ESOLU/176-211  AC A0A6Q2XL14.1
#=GS A0A4W4FIT1_ELEEL/178-214  AC A0A4W4FIT1.1
#=GS A0A5J5CHA3_9PERO/162-197  AC A0A5J5CHA3.1
#=GS A0A3Q2UGX1_CHICK/154-189  AC A0A3Q2UGX1.1
#=GS A0A2K6KY96_RHIBE/213-249  AC A0A2K6KY96.1
#=GS A0A452EFI8_CAPHI/214-250  AC A0A452EFI8.1
#=GS A0A3P8S2K7_AMPPE/166-201  AC A0A3P8S2K7.1
#=GS A0A2K6QDK1_RHIRO/212-248  AC A0A2K6QDK1.1
#=GS M3WLR5_FELCA/214-250      AC M3WLR5.3
#=GS A0A1D5QI02_MACMU/212-248  AC A0A1D5QI02.1
#=GS A0A2K6FHE2_PROCO/214-250  AC A0A2K6FHE2.1
#=GS A0A5N4D1Y6_CAMDR/214-250  AC A0A5N4D1Y6.1
#=GS A0A1S3NGR1_SALSA/178-213  AC A0A1S3NGR1.1
#=GS A0A3B5K735_TAKRU/99-134   AC A0A3B5K735.1
#=GS A0A096P5F6_PAPAN/149-185  AC A0A096P5F6.2
#=GS A0A484C1N6_PERFV/162-197  AC A0A484C1N6.1
#=GS A0A3M0JQS6_HIRRU/7-42     AC A0A3M0JQS6.1
#=GS A0A485PDK0_LYNPA/13-49    AC A0A485PDK0.1
#=GS G1LME8_AILME/111-147      AC G1LME8.1
#=GS A0A2K5YQJ5_MANLE/13-49    AC A0A2K5YQJ5.1
#=GS A0A1L8ERW6_XENLA/111-144  AC A0A1L8ERW6.1
#=GS MSL1_MOUSE/216-252        AC Q6PDM1.1
#=GS U3JA58_DANRE/158-193      AC U3JA58.1
#=GS A0A2B4SPV3_STYPI/114-149  AC A0A2B4SPV3.1
#=GS A0A2U4BNX1_TURTR/214-250  AC A0A2U4BNX1.1
#=GS A0A4W5Q3G2_9TELE/178-213  AC A0A4W5Q3G2.1
#=GS A0A670JS33_PODMU/236-272  AC A0A670JS33.1
#=GS A0A2Y9M314_DELLE/214-250  AC A0A2Y9M314.1
#=GS H0WSU4_OTOGA/214-250      AC H0WSU4.1
#=GS A0A444UHX4_ACIRT/219-255  AC A0A444UHX4.1
#=GS A0A643CER5_BALPH/153-189  AC A0A643CER5.1
#=GS F6XDL9_MACMU/212-248      AC F6XDL9.2
#=GS M4AKD3_XIPMA/160-195      AC M4AKD3.2
#=GS A0A3P8WE83_CYNSE/98-133   AC A0A3P8WE83.1
#=GS A0A3Q1N7Z0_BOVIN/214-250  AC A0A3Q1N7Z0.1
#=GS G3I5M6_CRIGR/191-227      AC G3I5M6.1
#=GS G3R866_GORGO/201-237      AC G3R866.2
#=GS A0A2U3VJL3_ODORO/214-250  AC A0A2U3VJL3.1
#=GS A0A2Y9K752_ENHLU/214-250  AC A0A2Y9K752.1
#=GS A0A4W5L7J3_9TELE/184-220  AC A0A4W5L7J3.1
#=GS A0A455BDM3_PHYMC/214-250  AC A0A455BDM3.1
#=GS MSL1_DANRE/167-203        AC A9JRX0.1
#=GS A0A3Q2WEV2_HAPBU/158-193  AC A0A3Q2WEV2.1
#=GS A0A2U9CQQ3_SCOMX/162-197  AC A0A2U9CQQ3.1
#=GS A0A2I4BR72_9TELE/159-195  AC A0A2I4BR72.1
#=GS F7GBL6_MONDO/237-273      AC F7GBL6.2
#=GS A0A2R9A049_PANPA/13-49    AC A0A2R9A049.1
#=GS A0A4X2K9R3_VOMUR/209-245  AC A0A4X2K9R3.1
#=GS H3AKQ8_LATCH/16-52        AC H3AKQ8.1
#=GS F6YYZ7_HORSE/214-250      AC F6YYZ7.2
#=GS F7IP38_CALJA/214-250      AC F7IP38.2
#=GS F1RB13_DANRE/167-203      AC F1RB13.1
#=GS A0A1U7QYZ1_MESAU/214-250  AC A0A1U7QYZ1.1
#=GS H2NU85_PONAB/214-250      AC H2NU85.2
#=GS A0A3Q1FAY7_9TELE/163-198  AC A0A3Q1FAY7.1
#=GS A0A2K5PPD3_CEBCA/214-250  AC A0A2K5PPD3.1
#=GS A0A3P8XX26_ESOLU/176-211  AC A0A3P8XX26.1
#=GS A0A2K6T8S7_SAIBB/214-250  AC A0A2K6T8S7.1
#=GS A0A341B8M2_NEOAA/214-250  AC A0A341B8M2.1
#=GS A0A340Y0Z2_LIPVE/214-250  AC A0A340Y0Z2.1
#=GS A0A3P9BM76_9CICH/158-193  AC A0A3P9BM76.1
#=GS A0A5N4D208_CAMDR/214-250  AC A0A5N4D208.1
#=GS W5L8X9_ASTMX/176-212      AC W5L8X9.2
#=GS A0A4W6DZ80_LATCA/166-201  AC A0A4W6DZ80.1
#=GS G3T4Z6_LOXAF/214-250      AC G3T4Z6.1
#=GS A0A4W5JS76_9TELE/179-214  AC A0A4W5JS76.1
#=GS A0A674GJ89_TAEGU/122-157  AC A0A674GJ89.1
#=GS B3TDE0_SALSA/179-214      AC B3TDE0.1
#=GS A0A665W054_ECHNA/99-134   AC A0A665W054.1
#=GS W5N7P5_LEPOC/177-213      AC W5N7P5.1
#=GS A0A1S3S6L2_SALSA/184-220  AC A0A1S3S6L2.1
#=GS A0A4D9EKC4_9SAUR/184-219  AC A0A4D9EKC4.1
#=GS A0A674CUJ2_SALTR/94-129   AC A0A674CUJ2.1
#=GS A0A5F8GD20_MONDO/237-273  AC A0A5F8GD20.1
#=GS A0A4U5VN79_COLLU/161-196  AC A0A4U5VN79.1
#=GS A0A669CK64_ORENI/158-193  AC A0A669CK64.1
#=GS A0A452IAZ2_9SAUR/193-228  AC A0A452IAZ2.1
#=GS A0A1U7UIU6_CARSF/13-49    AC A0A1U7UIU6.1
#=GS A0A553MPP5_9TELE/143-178  AC A0A553MPP5.1
#=GS A0A6I8N4F1_ORNAN/402-436  AC A0A6I8N4F1.1
#=GS H2MAM4_ORYLA/163-198      AC H2MAM4.2
#=GS A0A6G0HXK1_LARCR/162-197  AC A0A6G0HXK1.1
#=GS A0A3Q7X344_URSAR/214-250  AC A0A3Q7X344.1
#=GS A0A2Y9K0T5_ENHLU/214-250  AC A0A2Y9K0T5.1
#=GS A0A287D067_ICTTR/214-250  AC A0A287D067.1
#=GS A0A667WUD8_9TELE/166-201  AC A0A667WUD8.1
#=GS G1KB74_ANOCA/106-142      AC G1KB74.1
#=GS H2QCV9_PANTR/214-250      AC H2QCV9.1
#=GS A0A2G9P9D5_LITCT/116-148  AC A0A2G9P9D5.1
#=GS A0A3Q3EYK6_9LABR/162-197  AC A0A3Q3EYK6.1
#=GS A0A2K5F851_AOTNA/214-250  AC A0A2K5F851.1
#=GS A0A671FG29_RHIFE/214-250  AC A0A671FG29.1
#=GS A0A2K5V383_MACFA/212-248  AC A0A2K5V383.1
#=GS A0A1S3A8M8_ERIEU/218-254  AC A0A1S3A8M8.1
#=GS A0A669EUV9_ORENI/42-77    AC A0A669EUV9.1
#=GS A0A3Q1F922_9TELE/163-198  AC A0A3Q1F922.1
#=GS L8IF29_9CETA/53-89        AC L8IF29.1
#=GS A0A2K6BKF8_MACNE/212-248  AC A0A2K6BKF8.1
#=GS A0A1S3Q3F2_SALSA/179-214  AC A0A1S3Q3F2.1
#=GS A0A3P8XV12_ESOLU/176-211  AC A0A3P8XV12.1
#=GS A0A3Q7T949_VULVU/214-250  AC A0A3Q7T949.1
#=GS A0A498LNC8_LABRO/157-193  AC A0A498LNC8.1
#=GS A0A4W5JS86_9TELE/179-214  AC A0A4W5JS86.1
#=GS A0A2K6FHE0_PROCO/214-250  AC A0A2K6FHE0.1
#=GS A0A151PC94_ALLMI/6-41     AC A0A151PC94.1
#=GS A0A2K5NGZ5_CERAT/212-248  AC A0A2K5NGZ5.1
#=GS A0A2Y9I7J5_NEOSC/214-250  AC A0A2Y9I7J5.1
#=GS A0A6I8PG31_ORNAN/402-436  AC A0A6I8PG31.1
#=GS A0A402G297_9SAUR/205-241  AC A0A402G297.1
#=GS A0A6A5E028_PERFL/162-197  AC A0A6A5E028.1
#=GS A0A556TV39_BAGYA/163-199  AC A0A556TV39.1
#=GS A0A4W5KG72_9TELE/182-218  AC A0A4W5KG72.1
#=GS H2MAN0_ORYLA/52-87        AC H2MAN0.2
#=GS A0A2K5NGP9_CERAT/212-248  AC A0A2K5NGP9.1
#=GS A0A4W5JDK9_9TELE/179-214  AC A0A4W5JDK9.1
#=GS A0A315VEE1_GAMAF/160-195  AC A0A315VEE1.1
#=GS A0A2K6BKG3_MACNE/212-248  AC A0A2K6BKG3.1
#=GS D3ZBD0_RAT/215-251        AC D3ZBD0.1
#=GS A0A2K6T8T2_SAIBB/214-250  AC A0A2K6T8T2.1
#=GS A0A2K5F816_AOTNA/214-250  AC A0A2K5F816.1
#=GS A0A2I3MWQ7_PAPAN/149-185  AC A0A2I3MWQ7.1
#=GS A0A3Q3LLY0_9TELE/165-201  AC A0A3Q3LLY0.1
#=GS A0A673UXG6_SURSU/348-384  AC A0A673UXG6.1
#=GS A0A452RJS1_URSAM/214-250  AC A0A452RJS1.1
#=GS E1B8E9_BOVIN/214-250      AC E1B8E9.1
#=GS A0A4W5Q3I5_9TELE/178-213  AC A0A4W5Q3I5.1
#=GS A0A2R8RMP0_DANRE/158-193  AC A0A2R8RMP0.1
#=GS A0A444UQ00_ACIRT/181-216  AC A0A444UQ00.1
#=GS A0A401SQ78_CHIPU/145-180  AC A0A401SQ78.1
#=GS A0A1L8EKK2_XENLA/113-146  AC A0A1L8EKK2.1
#=GS W5KMM9_ASTMX/180-216      AC W5KMM9.2
#=GS A0A671WN16_SPAAU/35-69    AC A0A671WN16.1
#=GS A0A667X5Y2_9TELE/83-118   AC A0A667X5Y2.1
#=GS A0A2Y9M8G2_DELLE/214-250  AC A0A2Y9M8G2.1
#=GS A0A5F8A787_MACMU/212-248  AC A0A5F8A787.1
#=GS A0A674CV61_SALTR/178-213  AC A0A674CV61.1
#=GS A0A337RWL6_FELCA/214-250  AC A0A337RWL6.1
#=GS A0A3Q4NA91_NEOBR/156-191  AC A0A3Q4NA91.1
#=GS A0A672YED6_9TELE/124-159  AC A0A672YED6.1
#=GS A0A452IBG8_9SAUR/193-228  AC A0A452IBG8.1
#=GS A0A4W2ITA9_BOBOX/214-250  AC A0A4W2ITA9.1
#=GS A0A667X9Q4_9TELE/166-201  AC A0A667X9Q4.1
#=GS A0A5N5MFB8_PANHP/172-208  AC A0A5N5MFB8.1
#=GS A0A5N4D1S0_CAMDR/214-250  AC A0A5N4D1S0.1
#=GS A0A3Q7S0F8_VULVU/214-250  AC A0A3Q7S0F8.1
#=GS A0A3B3HYW2_ORYLA/163-198  AC A0A3B3HYW2.1
#=GS A0A1D5P2A2_CHICK/154-189  AC A0A1D5P2A2.2
#=GS J3QQY0_HUMAN/214-250      AC J3QQY0.1
#=GS A0A218UMH6_9PASE/7-42     AC A0A218UMH6.1
#=GS A0A498N0W3_LABRO/168-204  AC A0A498N0W3.1
#=GS A0A3Q1HYN1_ANATE/166-201  AC A0A3Q1HYN1.1
#=GS L9JWZ8_TUPCH/13-49        AC L9JWZ8.1
#=GS A0A341BA61_NEOAA/214-250  AC A0A341BA61.1
#=GS A0A151PD84_ALLMI/6-41     AC A0A151PD84.1
#=GS A0A2U9CNG1_SCOMX/162-197  AC A0A2U9CNG1.1
#=GS A0A286ZQ98_PIG/214-250    AC A0A286ZQ98.1
#=GS A0A3Q1AQB8_AMPOC/166-201  AC A0A3Q1AQB8.1
#=GS A0A3Q2ZPI4_KRYMA/164-200  AC A0A3Q2ZPI4.1
#=GS A0A2K5PPA2_CEBCA/214-250  AC A0A2K5PPA2.1
#=GS A0A401PBC7_SCYTO/127-161  AC A0A401PBC7.1
#=GS S9YIG0_CAMFR/13-49        AC S9YIG0.1
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#=GC SS_cons                         ...--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
#=GC seq_cons                        ...t.ssoQAuCL+QILLLQLDLIEQQQQQLQuK-KEI-EL
//
DBGET integrated database retrieval system