#=GF ID   Mce4_CUP1
#=GF AC   PF11887.12
#=GF DE   Cholesterol uptake porter CUP1 of Mce4, putative
#=GF PI   DUF3407;
#=GF AU   Assefa S;0000-0003-2178-533X
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   PFAM-B_3559 (release 23.0)
#=GF GA   32.60 32.60;
#=GF TC   32.60 32.60;
#=GF NC   32.50 32.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18955493
#=GF RT   The actinobacterial mce4 locus encodes a steroid transporter.
#=GF RA   Mohn WW, van der Geize R, Stewart GR, Okamoto S, Liu J,
#=GF RA   Dijkhuizen L, Eltis LD;
#=GF RL   J Biol Chem. 2008;283:35368-35374.
#=GF DR   INTERPRO; IPR024516;
#=GF DR   TC; 3.A.1;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Mce4_CUP1 is a family of putative Mce4 transporters of
#=GF CC   cholesterol.  The domain is found associated with Pfam:PF02470.
#=GF CC   The full TCDB classification for this family in conjunction with
#=GF CC   PF02470 is TC:3.A.1.27.4.
#=GF SQ   9933
#=GS F8JUH3_STREN/126-338      AC F8JUH3.1
#=GS A0A0Q8DYG9_9ACTN/112-297  AC A0A0Q8DYG9.1
#=GS A0A1H3LEP3_9PSEU/117-338  AC A0A1H3LEP3.1
#=GS A0A4R2CTZ1_9NOCA/113-330  AC A0A4R2CTZ1.1
#=GS A0A7I7MSZ2_9MYCO/119-297  AC A0A7I7MSZ2.1
#=GS A0A177HGU9_9ACTN/117-319  AC A0A177HGU9.1
#=GS X8C7U6_MYCXE/1-40         AC X8C7U6.1
#=GS A0A6H1A0L0_9ACTN/105-323  AC A0A6H1A0L0.1
#=GS A0A0Q8DP73_9ACTN/116-304  AC A0A0Q8DP73.1
#=GS A0A0J6Z4T9_MYCCU/118-316  AC A0A0J6Z4T9.1
#=GS W9GIG9_9MICO/143-360      AC W9GIG9.1
#=GS A0A7I7MUU7_9MYCO/112-330  AC A0A7I7MUU7.1
#=GS A0A557ZPF3_9PSEU/122-337  AC A0A557ZPF3.1
#=GS X8B7W2_MYCAV/111-329      AC X8B7W2.1
#=GS A0A0N0AY56_9ACTN/122-344  AC A0A0N0AY56.1
#=GS A0A4R2QB93_9PSEU/117-322  AC A0A4R2QB93.1
#=GS A0A372JT64_9ACTN/120-302  AC A0A372JT64.1
#=GS A0A1G6NN70_9NOCA/118-328  AC A0A1G6NN70.1
#=GS Q742S6_MYCPA/144-358      AC Q742S6.1
#=GS A0A370GX58_9NOCA/131-340  AC A0A370GX58.1
#=GS A0A6L5EVW9_9PSEU/127-350  AC A0A6L5EVW9.1
#=GS A0A0D5AFX0_9NOCA/121-344  AC A0A0D5AFX0.1
#=GS W9AKY1_MYCCO/117-305      AC W9AKY1.1
#=GS A0A6G9YDL1_9NOCA/124-322  AC A0A6G9YDL1.1
#=GS A0A1I0YKM2_9PSEU/116-331  AC A0A1I0YKM2.1
#=GS A0A1W2FAU3_KIBAR/109-331  AC A0A1W2FAU3.1
#=GS K6W9V2_9ACTN/134-355      AC K6W9V2.1
#=GS W5WIN9_9PSEU/104-284      AC W5WIN9.1
#=GS A0A1E3S0Z6_9MYCO/112-317  AC A0A1E3S0Z6.1
#=GS A0A542CSB5_AMYCI/117-333  AC A0A542CSB5.1
#=GS A0A1X1RA50_MYCBE/118-329  AC A0A1X1RA50.1
#=GS A0A4R2CW16_9NOCA/109-300  AC A0A4R2CW16.1
#=GS A0A853CFE1_9ACTN/118-327  AC A0A853CFE1.1
#=GS A0A1X0DCL8_MYCHE/118-335  AC A0A1X0DCL8.1
#=GS E2SCQ6_9ACTN/114-318      AC E2SCQ6.1
#=GS A0A178X249_9PSEU/114-322  AC A0A178X249.1
#=GS A0A6G7YCB0_9ACTN/110-311  AC A0A6G7YCB0.1
#=GS A0A1N2ZMB5_9MYCO/129-354  AC A0A1N2ZMB5.1
#=GS A0A4R4R6G7_9ACTN/122-344  AC A0A4R4R6G7.1
#=GS A0A372GL99_9ACTN/119-339  AC A0A372GL99.1
#=GS A0A1G6RF83_9ACTN/111-288  AC A0A1G6RF83.1
#=GS A0A5N5UQM8_MYCPH/118-327  AC A0A5N5UQM8.1
#=GS A0A5Q4SZE6_9ACTN/119-337  AC A0A5Q4SZE6.1
#=GS A0A448I3K6_MYCCI/125-339  AC A0A448I3K6.1
#=GS A0A6H0CVW8_9ACTN/122-344  AC A0A6H0CVW8.1
#=GS A0A5S9QWM0_MYCVN/116-318  AC A0A5S9QWM0.1
#=GS A0A1A3PPS7_9MYCO/127-334  AC A0A1A3PPS7.1
#=GS L7LDJ2_9ACTN/116-328      AC L7LDJ2.1
#=GS A0A4Q7KPK4_9PSEU/131-334  AC A0A4Q7KPK4.1
#=GS A0A1I5DQH1_9PSEU/119-316  AC A0A1I5DQH1.1
#=GS A0A2A7N548_MYCAG/114-310  AC A0A2A7N548.1
#=GS A0A1G8B907_9NOCA/114-331  AC A0A1G8B907.1
#=GS A0A4Y9NE82_9ACTN/124-327  AC A0A4Y9NE82.1
#=GS A0A5S9R246_MYCVN/117-309  AC A0A5S9R246.1
#=GS A0A1H9XP35_9PSEU/117-339  AC A0A1H9XP35.1
#=GS A0A0Q8E8S2_9ACTN/114-306  AC A0A0Q8E8S2.1
#=GS A0A132PBQ7_9MYCO/124-282  AC A0A132PBQ7.1
#=GS A0A1X1R4L1_MYCBE/119-307  AC A0A1X1R4L1.1
#=GS W7SXC4_9PSEU/115-311      AC W7SXC4.1
#=GS A0A370IEI2_9NOCA/122-319  AC A0A370IEI2.1
#=GS A0A6N7I4D0_9PSEU/118-308  AC A0A6N7I4D0.1
#=GS A0A417Y193_9ACTN/156-356  AC A0A417Y193.1
#=GS A0A7W3QL86_ACTNM/121-320  AC A0A7W3QL86.1
#=GS A0A6N7I4E0_9PSEU/118-331  AC A0A6N7I4E0.1
#=GS A0A059MV72_9NOCA/112-317  AC A0A059MV72.1
#=GS A0A6I4MLR9_9ACTN/149-359  AC A0A6I4MLR9.1
#=GS A0A222VL89_9PSEU/115-321  AC A0A222VL89.1
#=GS A0A401Y4L0_9ACTN/120-335  AC A0A401Y4L0.1
#=GS A0A7I7K5E7_9MYCO/125-313  AC A0A7I7K5E7.1
#=GS A0A1G7ZT03_9NOCA/118-318  AC A0A1G7ZT03.1
#=GS A0A1I6RF45_9PSEU/117-316  AC A0A1I6RF45.1
#=GS A0A6V8K4T2_9ACTN/114-328  AC A0A6V8K4T2.1
#=GS A0A5B1LJR2_9ACTN/118-317  AC A0A5B1LJR2.1
#=GS K5BH35_MYCHD/118-323      AC K5BH35.1
#=GS A0A2X4US63_9NOCA/129-350  AC A0A2X4US63.1
#=GS A0A365GW32_9ACTN/121-330  AC A0A365GW32.1
#=GS A0A543AZP1_9ACTN/113-310  AC A0A543AZP1.1
#=GS A0A417XS07_9ACTN/124-321  AC A0A417XS07.1
#=GS K6V1T0_9ACTN/121-313      AC K6V1T0.1
#=GS A0R4N4_MYCS2/122-295      AC A0R4N4.1
#=GS A0A7Y9S2M0_9ACTN/131-344  AC A0A7Y9S2M0.1
#=GS A0A4V1A0T0_9NOCA/115-326  AC A0A4V1A0T0.1
#=GS X8F9E2_MYCUL/106-246      AC X8F9E2.1
#=GS A0A541B8Z5_9NOCA/130-334  AC A0A541B8Z5.1
#=GS A0A238UYL8_9ACTN/123-304  AC A0A238UYL8.1
#=GS A0A4S8NMR0_9ACTN/115-324  AC A0A4S8NMR0.1
#=GS W5TA12_9NOCA/116-336      AC W5TA12.1
#=GS A0A0P0SDP3_9PSEU/115-316  AC A0A0P0SDP3.1
#=GS E2SEK0_9ACTN/127-346      AC E2SEK0.1
#=GS A0A653WYK3_9ACTN/112-309  AC A0A653WYK3.1
#=GS A0A6H9V8Y5_9ACTN/116-330  AC A0A6H9V8Y5.1
#=GS A0A366DBS7_9NOCA/117-335  AC A0A366DBS7.1
#=GS A0A4T0V994_9ACTN/118-305  AC A0A4T0V994.1
#=GS G7CJS3_MYCT3/114-330      AC G7CJS3.1
#=GS A0A0K2YPA2_9NOCA/128-337  AC A0A0K2YPA2.1
#=GS A0A6I3KMQ5_9NOCA/121-305  AC A0A6I3KMQ5.1
#=GS A0A448IB46_MYCCI/120-338  AC A0A448IB46.1
#=GS A0A4R4SGC8_9ACTN/129-336  AC A0A4R4SGC8.1
#=GS A0A285L8B9_9NOCA/126-302  AC A0A285L8B9.1
#=GS A0A176LAF8_9ACTN/119-324  AC A0A176LAF8.1
#=GS A0A1V0A3A4_9ACTN/111-298  AC A0A1V0A3A4.1
#=GS A0A1A0M2D1_9MYCO/118-335  AC A0A1A0M2D1.1
#=GS A0A2S8KBM0_9MYCO/127-301  AC A0A2S8KBM0.1
#=GS V6L0Q7_STRRC/119-317      AC V6L0Q7.1
#=GS K5B7D8_MYCHD/116-325      AC K5B7D8.1
#=GS A0A1G9Z3X5_9ACTN/117-314  AC A0A1G9Z3X5.1
#=GS A0A1Q9UE11_9NOCA/127-301  AC A0A1Q9UE11.1
#=GS G7H2R5_9ACTN/119-316      AC G7H2R5.1
#=GS A0A7H1BCP4_9ACTN/119-327  AC A0A7H1BCP4.1
#=GS X8B3J7_MYCAV/115-311      AC X8B3J7.1
#=GS A0A1M5GQ80_9ACTN/120-296  AC A0A1M5GQ80.1
#=GS A0A541B8P7_9NOCA/118-348  AC A0A541B8P7.1
#=GS A0A2S2C879_9NOCA/118-321  AC A0A2S2C879.1
#=GS A0A7K0BYL7_9ACTN/120-325  AC A0A7K0BYL7.1
#=GS A0A1Q9VF47_9PSEU/118-322  AC A0A1Q9VF47.1
#=GS A0A2X4TXR2_9NOCA/113-326  AC A0A2X4TXR2.1
#=GS A0A7J0CFH4_9ACTN/1-193    AC A0A7J0CFH4.1
#=GS A0A1A0Q876_9MYCO/128-334  AC A0A1A0Q876.1
#=GS A0A7I7K7K7_9MYCO/126-306  AC A0A7I7K7K7.1
#=GS A1T3L1_MYCVP/118-335      AC A1T3L1.1
#=GS A0A1H5T4P7_9ACTN/160-370  AC A0A1H5T4P7.1
#=GS A0A6H1A0V0_9ACTN/111-307  AC A0A6H1A0V0.1
#=GS A0A1E3R862_9MYCO/113-327  AC A0A1E3R862.1
#=GS A0A250V6E0_STROL/136-350  AC A0A250V6E0.1
#=GS A0A177YKU2_9NOCA/125-312  AC A0A177YKU2.1
#=GS A0A378YGC7_9NOCA/117-345  AC A0A378YGC7.1
#=GS A0A239IFW2_9ACTN/128-375  AC A0A239IFW2.1
#=GS A0A7I7Y096_9MYCO/112-303  AC A0A7I7Y096.1
#=GS A0A0Q7BBF9_9ACTN/120-334  AC A0A0Q7BBF9.1
#=GS A0A1I5QEP6_9ACTN/123-345  AC A0A1I5QEP6.1
#=GS A0A1M6X7P1_PSETH/125-328  AC A0A1M6X7P1.1
#=GS A0A7G1L062_9NOCA/126-348  AC A0A7G1L062.1
#=GS A0A542DWI7_9MICO/117-324  AC A0A542DWI7.1
#=GS A0A1Q8CQ42_9PSEU/119-324  AC A0A1Q8CQ42.1
#=GS A0A378TH78_9MYCO/118-329  AC A0A378TH78.1
#=GS A0A177YKG8_9NOCA/115-332  AC A0A177YKG8.1
#=GS A0A6G7YCQ5_9ACTN/118-325  AC A0A6G7YCQ5.1
#=GS A0A3E0HA36_9PSEU/116-318  AC A0A3E0HA36.1
#=GS A0A3N0DVB5_9ACTN/134-317  AC A0A3N0DVB5.1
#=GS A0A1X0HI39_9MYCO/114-326  AC A0A1X0HI39.1
#=GS A0A1J0VUF0_9NOCA/130-355  AC A0A1J0VUF0.1
#=GS A0A7G1I4I8_MYCKA/363-529  AC A0A7G1I4I8.1
#=GS A0A853AYZ9_9PSEU/114-328  AC A0A853AYZ9.1
#=GS A0A1Q9UE24_9NOCA/118-273  AC A0A1Q9UE24.1
#=GS A0A0Q7ZYJ6_9ACTN/113-321  AC A0A0Q7ZYJ6.1
#=GS A0A7I7S7H8_9MYCO/110-329  AC A0A7I7S7H8.1
#=GS A0A6I3L1U2_9NOCA/119-292  AC A0A6I3L1U2.1
#=GS A0A7I7JWK3_9MYCO/131-306  AC A0A7I7JWK3.1
#=GS A0A1Q5HJT1_9ACTN/119-326  AC A0A1Q5HJT1.1
#=GS A0A6G7YCB3_9ACTN/122-339  AC A0A6G7YCB3.1
#=GS A0A7K0CWF9_9NOCA/108-327  AC A0A7K0CWF9.1
#=GS A0A3N0DSN1_9ACTN/135-341  AC A0A3N0DSN1.1
#=GS A0A7W9GA64_9ACTN/106-307  AC A0A7W9GA64.1
#=GS A0A1H0V738_9MICO/116-323  AC A0A1H0V738.1
#=GS A0A4Y9MWW2_9MYCO/117-309  AC A0A4Y9MWW2.1
#=GS A0A0N9I1U2_9PSEU/118-322  AC A0A0N9I1U2.1
#=GS A0A7W9PI25_9NOCA/128-349  AC A0A7W9PI25.1
#=GS A0A3M0HZG9_9ACTN/148-349  AC A0A3M0HZG9.1
#=GS A0A7K3DF57_9ACTN/139-343  AC A0A7K3DF57.1
#=GS A0A0A1DL73_NOCSI/116-309  AC A0A0A1DL73.2
#=GS A0A852RPG1_9ACTN/135-353  AC A0A852RPG1.1
#=GS A0A7I7SDE2_9MYCO/128-356  AC A0A7I7SDE2.1
#=GS M0QKH3_9ACTN/124-342      AC M0QKH3.1
#=GS A0A1X0D5V8_9MYCO/119-336  AC A0A1X0D5V8.1
#=GS A0A1G9YZR4_ALLAB/115-348  AC A0A1G9YZR4.1
#=GS A0A7I7SFS8_9MYCO/123-234  AC A0A7I7SFS8.1
#=GS A0A2A7NG45_MYCAG/115-332  AC A0A2A7NG45.1
#=GS A0A3N0GVS8_9ACTN/124-319  AC A0A3N0GVS8.1
#=GS A0A5N0UWP1_9PSEU/123-308  AC A0A5N0UWP1.1
#=GS A0A1I6SC14_9PSEU/119-310  AC A0A1I6SC14.1
#=GS A0A840F4N0_9ACTN/130-345  AC A0A840F4N0.1
#=GS A0A2W2BQZ5_9ACTN/114-332  AC A0A2W2BQZ5.1
#=GS A0A1I1A046_9PSEU/115-319  AC A0A1I1A046.1
#=GS A0A6F8XIY5_9ACTN/114-322  AC A0A6F8XIY5.1
#=GS A0A3D9V6A7_THECX/130-343  AC A0A3D9V6A7.1
#=GS A0A0G3IIK6_9MYCO/118-295  AC A0A0G3IIK6.1
#=GS X8C8D5_MYCXE/89-181       AC X8C8D5.1
#=GS A0A132T674_9MYCO/116-310  AC A0A132T674.1
#=GS A0A2S2C6Q0_9NOCA/111-329  AC A0A2S2C6Q0.1
#=GS A0A448IAG3_MYCCI/137-317  AC A0A448IAG3.1
#=GS A0A1V9K0S3_9ACTN/128-336  AC A0A1V9K0S3.1
#=GS A0A4P7ICM1_9ACTN/118-334  AC A0A4P7ICM1.1
#=GS A0A1Q9LF58_9PSEU/120-342  AC A0A1Q9LF58.1
#=GS A0A417XSI9_9ACTN/115-329  AC A0A417XSI9.1
#=GS A0A6F8XIZ3_9ACTN/9-192    AC A0A6F8XIZ3.1
#=GS A0A2D3UKS5_STRC0/99-296   AC A0A2D3UKS5.1
#=GS A0A6I3J011_9ACTN/111-328  AC A0A6I3J011.1
#=GS A0A2M9J7I0_9ACTN/111-334  AC A0A2M9J7I0.1
#=GS A0A7W7CKB3_9PSEU/113-311  AC A0A7W7CKB3.1
#=GS V6KRQ9_STRRC/106-313      AC V6KRQ9.1
#=GS A0A1A0MGM1_9MYCO/139-380  AC A0A1A0MGM1.1
#=GS A0A3A5H8K4_9ACTN/120-302  AC A0A3A5H8K4.1
#=GS A0A1E3S334_9MYCO/130-348  AC A0A1E3S334.1
#=GS A0A1A0TGQ7_9MYCO/117-308  AC A0A1A0TGQ7.1
#=GS A0A318K467_9NOCA/121-321  AC A0A318K467.1
#=GS A0A2S6GWD3_9PSEU/123-346  AC A0A2S6GWD3.1
#=GS A0A1I5QEY3_9ACTN/133-359  AC A0A1I5QEY3.1
#=GS A0A1X1RPS2_MYCCE/115-319  AC A0A1X1RPS2.1
#=GS A0A5A7WC47_9MYCO/117-300  AC A0A5A7WC47.1
#=GS A0A7G9R6Z1_9ACTN/130-351  AC A0A7G9R6Z1.1
#=GS A0A5C4VLJ3_9ACTN/103-318  AC A0A5C4VLJ3.1
#=GS A0A448IAL4_MYCCI/124-321  AC A0A448IAL4.1
#=GS A0A1X1T0K0_9MYCO/115-322  AC A0A1X1T0K0.1
#=GS A0A6I4PN83_9ACTN/112-299  AC A0A6I4PN83.1
#=GS A0A5D0NVF6_9ACTN/119-339  AC A0A5D0NVF6.1
#=GS A0A7G7BEE6_9ACTN/120-329  AC A0A7G7BEE6.1
#=GS A0A840NJA4_9PSEU/123-345  AC A0A840NJA4.1
#=GS A0A285L0C1_9NOCA/117-310  AC A0A285L0C1.1
#=GS V5XG73_MYCNE/122-340      AC V5XG73.1
#=GS A0A1P8YCC9_9NOCA/117-319  AC A0A1P8YCC9.1
#=GS E6S9N5_INTC7/123-309      AC E6S9N5.1
#=GS A0A2S2BR07_9NOCA/119-326  AC A0A2S2BR07.1
#=GS A0A4S2V4Z5_9ACTN/119-327  AC A0A4S2V4Z5.1
#=GS A0A1X0H9B5_9MYCO/113-313  AC A0A1X0H9B5.1
#=GS A0A1X0H5Q5_9MYCO/128-325  AC A0A1X0H5Q5.1
#=GS A0A1X1TQ36_9MYCO/130-344  AC A0A1X1TQ36.1
#=GS A0A1X1T0L1_9MYCO/115-320  AC A0A1X1T0L1.1
#=GS A0A6I3L5W8_9NOCA/132-277  AC A0A6I3L5W8.1
#=GS C6WH39_ACTMD/115-321      AC C6WH39.1
#=GS A0A8J3YXS1_9ACTN/114-303  AC A0A8J3YXS1.1
#=GS Q9F356_STRCO/122-344      AC Q9F356.1
#=GS L7LGN5_9ACTN/130-363      AC L7LGN5.1
#=GS A0A3B7D117_9ACTN/107-310  AC A0A3B7D117.1
#=GS A0A0D1L4M0_9MYCO/128-310  AC A0A0D1L4M0.1
#=GS A0A3S4VGK0_MYCCI/115-314  AC A0A3S4VGK0.1
#=GS K5BJ63_MYCHD/103-310      AC K5BJ63.1
#=GS A0A6B2DAI3_9PSEU/118-315  AC A0A6B2DAI3.1
#=GS A0A4Y3WN56_9PSEU/126-350  AC A0A4Y3WN56.1
#=GS A0A841D879_PLAVE/124-327  AC A0A841D879.1
#=GS K5BD94_MYCHD/107-327      AC K5BD94.1
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