GenomeNet

Database: Pfam
Entry: Mgr1
LinkDB: Mgr1
Original site: Mgr1 
#=GF ID   Mgr1
#=GF AC   PF08602.12
#=GF DE   Mgr1-like, i-AAA protease complex subunit
#=GF AU   Wood V;0000-0001-6330-7526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Manual
#=GF GA   25.00 25.00;
#=GF TC   26.80 26.60;
#=GF NC   21.40 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16267274
#=GF RT   A Genomewide Screen for Petite-negative Yeast Strains Yields a
#=GF RT   New Subunit of the i-AAA Protease Complex. 
#=GF RA   Dunn CD, Lee MS, Spencer FA, Jensen RE; 
#=GF RL   Mol Biol Cell. 2006;17:213-226.
#=GF DR   INTERPRO; IPR013911;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The S. cerevisiae Mgr1 protein has been shown to be required for
#=GF CC   mitochondrial viability in yeast lacking mitochondrial DNA. It
#=GF CC   is a mitochondrial inner membrane protein, which interacts with
#=GF CC   Yme1 and is a new subunit of the i-AAA protease complex [1].
#=GF SQ   80
#=GS Q6C720_YARLI/1-66         AC Q6C720.1
#=GS H2ATH6_KAZAF/103-388      AC H2ATH6.1
#=GS G8BU91_TETPH/1-389        AC G8BU91.1
#=GS A0A167BYH7_9ASCO/19-212   AC A0A167BYH7.1
#=GS A0A1S7HM68_9SACH/1-376    AC A0A1S7HM68.1
#=GS G0VAV2_NAUCC/1-441        AC G0VAV2.1
#=GS G8BE08_CANPC/112-170      AC G8BE08.1
#=GS MGR1_CANAL/1-119          AC Q5AHC2.1
#=GS K0KJQ3_WICCF/125-269      AC K0KJQ3.1
#=GS K0KJQ3_WICCF/1-87         AC K0KJQ3.1
#=GS A0A0H5CCR9_CYBJN/122-265  AC A0A0H5CCR9.1
#=GS A0A1D2VMG2_9ASCO/187-294  AC A0A1D2VMG2.1
#=GS G3BFN9_CANTC/211-322      AC G3BFN9.1
#=GS A5DP43_PICGU/1-98         AC A5DP43.2
#=GS G8JM33_ERECY/1-368        AC G8JM33.1
#=GS K0KJQ3_WICCF/76-128       AC K0KJQ3.1
#=GS G8YP11_PICSO/1-98         AC G8YP11.1
#=GS A0A1E3P7S5_WICAA/80-136   AC A0A1E3P7S5.1
#=GS C5DZ37_ZYGRC/1-370        AC C5DZ37.1
#=GS MGR1_LODEL/1-105          AC A5DV96.1
#=GS A0A061BBC2_CYBFA/132-276  AC A0A061BBC2.1
#=GS A0A1G4JW00_9SACH/1-368    AC A0A1G4JW00.1
#=GS J5RVD0_SACK1/138-286      AC J5RVD0.1
#=GS J7S5H4_KAZNA/12-401       AC J7S5H4.1
#=GS I2GWN9_TETBL/1-394        AC I2GWN9.1
#=GS G8BE08_CANPC/1-115        AC G8BE08.1
#=GS A0A1E5RI35_9ASCO/1-452    AC A0A1E5RI35.1
#=GS MGR1_ASHGO/1-366          AC Q751V6.1
#=GS A0A1S7I0U4_9SACH/1-376    AC A0A1S7I0U4.1
#=GS A0A376B9R3_9ASCO/1-451    AC A0A376B9R3.1
#=GS A0A1E5S1I5_HANUV/1-438    AC A0A1E5S1I5.1
#=GS G0W5H6_NAUDC/1-439        AC G0W5H6.1
#=GS J8Q7B9_SACAR/1-140        AC J8Q7B9.1
#=GS A0A367YLV8_9ASCO/1-100    AC A0A367YLV8.1
#=GS A0A1E4SC56_9ASCO/1-92     AC A0A1E4SC56.1
#=GS A0A1G4MGP8_LACFM/1-370    AC A0A1G4MGP8.1
#=GS A0A0H5CCR9_CYBJN/1-83     AC A0A0H5CCR9.1
#=GS A0A1E3QS19_9ASCO/6-79     AC A0A1E3QS19.1
#=GS W6MKE3_9ASCO/23-138       AC W6MKE3.1
#=GS MGR1_YEAST/1-139          AC P25573.1
#=GS J8Q7B9_SACAR/138-386      AC J8Q7B9.1
#=GS J5RVD0_SACK1/1-141        AC J5RVD0.1
#=GS A0A1E4REW8_9ASCO/1-118    AC A0A1E4REW8.1
#=GS A0A421JFQ0_9ASCO/1-98     AC A0A421JFQ0.1
#=GS C4YB94_CLAL4/9-95         AC C4YB94.1
#=GS G3AMP5_SPAPN/1-107        AC G3AMP5.1
#=GS A0A1G4JZB9_9SACH/1-372    AC A0A1G4JZB9.1
#=GS A0A0C7ND35_9SACH/1-372    AC A0A0C7ND35.1
#=GS A0A367XR92_9ASCO/1-101    AC A0A367XR92.1
#=GS MGR1_KLULA/2-351          AC Q6CUZ6.1
#=GS G8ZQS5_TORDC/1-395        AC G8ZQS5.1
#=GS MGR1_CANGA/1-445          AC Q6FX96.1
#=GS A0A4V1J3P2_9ASCO/25-115   AC A0A4V1J3P2.1
#=GS A0A1D2VMG2_9ASCO/34-136   AC A0A1D2VMG2.1
#=GS C4R0B9_KOMPG/6-89         AC C4R0B9.1
#=GS C5DK18_LACTC/47-417       AC C5DK18.1
#=GS A0A2T0FM18_9ASCO/1-55     AC A0A2T0FM18.1
#=GS G8YLN3_PICSO/1-100        AC G8YLN3.1
#=GS C5M5R4_CANTT/1-106        AC C5M5R4.1
#=GS G3BFN9_CANTC/1-96         AC G3BFN9.1
#=GS H2ATH6_KAZAF/1-111        AC H2ATH6.1
#=GS M3JFK7_CANMX/1-115        AC M3JFK7.1
#=GS MGR1_YEAST/139-388        AC P25573.1
#=GS A0A1E4TZS5_PACTA/5-79     AC A0A1E4TZS5.1
#=GS MGR1_LODEL/100-186        AC A5DV96.1
#=GS A7TFE5_VANPO/1-470        AC A7TFE5.1
#=GS A0A1E3QS19_9ASCO/113-264  AC A0A1E3QS19.1
#=GS MGR1_DEBHA/1-92           AC Q6BNL9.2
#=GS A0A1B7TCH9_9ASCO/1-391    AC A0A1B7TCH9.1
#=GS A0A1E3P7S5_WICAA/1-91     AC A0A1E3P7S5.1
#=GS A0A1E3P7S5_WICAA/139-273  AC A0A1E3P7S5.1
#=GS A0A1E3PIS1_9ASCO/4-85     AC A0A1E3PIS1.1
#=GS A0A1X7R3P6_9SACH/1-406    AC A0A1X7R3P6.1
#=GS A0A1E4REW8_9ASCO/155-314  AC A0A1E4REW8.1
#=GS MGR1_PICST/61-127         AC A3LN78.2
#=GS A0A1L0BHX6_9ASCO/42-125   AC A0A1L0BHX6.1
#=GS A0A1A0HH81_9ASCO/1-60     AC A0A1A0HH81.1
#=GS C5M5R4_CANTT/161-348      AC C5M5R4.1
#=GS A0A061BBC2_CYBFA/1-92     AC A0A061BBC2.1
#=GS A0A421JVF9_9ASCO/1-119    AC A0A421JVF9.1
Q6C720_YARLI/1-66                    ........................................................ma-------------...------.-...---NDK....DQDGFF........................PK....YQ.Q.PSFVLRMWGKLVPAADNKYALTIVCAAQMGVGV.LLLAYPR-.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rstfrakygk.......................................
H2ATH6_KAZAF/103-388                 .....................................................ieskp-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................-LQKLSRW.D....TTKKFIYLFSGTVILSQSLLELCRLSLLKYDPWYEEARCARDKKFFNDIIKYYNEGIDP..TK..I..QVKVKRSGGddsvSVN.P.NV.NEIKQSVAIVRAQNEASNPIIKWYGPI.E.LEPMSFNDYLGRME.YYLHMMEL...LQSR.Kir........nnDDNN.STNMLLNIISY....SNDEIE.K.VIEKNKQTRDVIMSDLskeislqqdnsnda.......eeepglrqditksiSSMMEQKRKQKVEHSS..NLLVPP......RNV.ILDPiQVKTSEDIDL..NEIWSLYDPWMNLGLDTSLSIKFIPTV.................................................
G8BU91_TETPH/1-389                   ..........................................................MTLYTPPDKNQ--...-KDKGD.A...AKNVDS....SNEPL-........................KL....YP.R.PSLGLKMWGPLVPASDNRVGLWSLVGAQTLIGL.FFLRRGWT.IRKNVNMRNLatg.............................vspAFKTDISNIPTLNRFS-.-N.GP.VAT..................---GTATTKPSIFA.........sILTRFI.KRQPTGSRF.GAry................................................................gyqNQQSWQGF.R....SFASLLYLFVGALVISQSTLEIMRLVLLKYDPWYDEAKSAREKKFFNDIVKYYHEGIDP..TK..I..KVKDASSGT....ALS.T.NS.PQVRQSVALVRAQAENESILTKWFGPV.Y.FKPMSFNDFLDKLE.YNLDIQDK...IDDK.K............KSKL.ISKSIQRKLRH....TPDELH.N.LKVINEENRKKTLQLL...................................DLNRGIGESDHQG--Q..KSEHPP......RGI.IMDD.ALTSPEEVDL..GEMWYLYNPWMNLALDTSLSIKFLPTV.................................................
A0A167BYH7_9ASCO/19-212              .............................................qqdaararqqavr-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.--------------KGQNP-SFWFGPT.G.YRAVEYKEWKRRMD.QALNKAQN...VGKSvN............LAKE.VYSEIRENNRQ...lSHKILE.E.LKRENEQDAQTRENKAlielkeeeghdiassssastsnsninsstsdsrnlN--TNNNNNSNGKSAT..GEKSRT......DSL.SVDS.LMSAIESLSTtkSDEWDALEPWEKLRLETDIAVRIMP--ht...............................................
A0A1S7HM68_9SACH/1-376               ..........................................................MALYTPPDKSSPQ...PRRSEV.E...EDKEGD....TQDDFK........................KF....YV.R.PSLGLRMWGPLVPASDNRIGLWTLVGIQTAVGA.FFLHRIRV.FRASLK----...................................VVKKDISDFPSLNRFST.TH.GE.MFL..................NPAKGGASSFFKSS..........S-----.TNGGIGIAR.IG.....................................................................KLFNSPRW.S....TFKNVVYLLAGTLLLSQSLLETSRLTVLKYDPWCEEARSVRDKKFYNDIIQFYHEGVDP..TK..V..KVKDATNGK....VMS.T.NI.PEVKQSVALVRAQAEAENLVIKWFGPL.E.YKPMSFTEFLDRLQ.YHFDIYDF...LQSK.R............TLKE.NAAQLSSQISH....SPSELE.E.YVRYNEEARQRIKDLV...................................----DNVPSGSIPVSP..QTRDLP.....lRGV.VLDA.DQQDADNIDF..EEIWSLYDPWMNLALDTSLSIKFLPTV.................................................
G0VAV2_NAUCC/1-441                   ..........................................................MALYTPPDKPDSS...NGDDHP.K...NGSIND....SNNDNDefe.................mkrhKF....YP.R.PSLGLKLWGPLVPASDNKNGLWTLIGVQTAMGV.FCFYRFRK.LGIRPFSTSPtasplgfik................nattfkqngkNTIKDIADLPSLNRFST.SH.GE.LLVndsa.........kgvtpGEISTALKPGLTGS..........SMSSFS.KKTSYDGKN.NE.....................................................................NFNYSSKF.T....TFKRALYIFTGALLLSQSLLETCRLEILKYDPWLEEAKSVRDKKLFNDIIKFYHEGIDP..TK..V..NVRDVMSGN....PVS.T.NI.PEVKQSVALVRAQSEAENPVIKWFGPI.E.YKPMTFTEYLDRVE.YHLEMFEY...FLSK.R............---A.VNTLLWETIRP....SSIALE.E.VKNKNDQFKEKIHKKFlksqpslhqqhm..........nqllpegsssektNTESKHPTEHALPPAM..-----G.....rRGI.VFDE.SIKSPEDIDL..KDIWSLYDPWMSLALDTSLSIKFIPTV.................................................
G8BE08_CANPC/112-170                 ...............................................nnrppqsvrsg-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.S....IFKSAVFVAVGATLVFGSGLEISRM-ILPYDPWYEEARHYRKM----------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------aikng............................................
MGR1_CANAL/1-119                     ..........................................................MGVYIPPPNDKDD..gDKKKQD.T...NSNTNQ....PTPPSSsspsgstt........iyipnpasSI....PR.N.PKVGL-IWGPLTPASDNLPALYSMIGLQFVIGC.GFFKYART.LSRL------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rpiggfqqqphahmapklvrt............................
K0KJQ3_WICCF/125-269                 ...............................................qaiargekpnf-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.----------------------WFGPL.D.YKPMSFKEWSEKVD.DWVEETES...QLNQ.-............---E.ESSSFITQNPQ....FHQVYK.Q.IRQLNKERNLEVLKNL...................................KTPGMNEFLGLNNSQF..INPEFD.....rPNL.TLPD.DNNLETNLDF..LEVWELNDPWESLGRDTDYVVRFIP--ky...............................................
K0KJQ3_WICCF/1-87                    ..........................................................MGLFIPPNSDKN-...-KDTQG.S...QNPSSD....SNKTI-........................-F....YT.R.PSVGLKLWGPLVPASDYLPGIYGLTALQTLLGL.TMFRHTRI.IWRQT-----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------slisrisk.........................................
A0A0H5CCR9_CYBJN/122-265             ................................................aiaqgkkpnw-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.----------------------WFGPL.D.QKPMSLAEWNEKMDvWILDQEEN...LDR-.-............----.QSTALVGSPEI....-KMGYN.H.IKEQNTRRQSEILEQLq.................................hNTFERNRPLHQSKVAL..RELHNP.....kHQV.VIPE.EYQSEENSDF..YEIWDLNDPWNVLANDANILVRFIPA-s................................................
A0A1D2VMG2_9ASCO/187-294             ...................................................inhpnye-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.------------------IFNSWFGPL.S.YKPIPFDEYLLRME.NWMNVSNY...ILQA.N............RKKI.IPILFPKVLDN....------.-.----------------...................................----------------..------......---.----.----------..---------------------------qiikipegediysnsflkerinllkthinsndkkslnifnltnsillnf
G3BFN9_CANTC/211-322                 .............................................ilqissisrlldh-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............---E.KFTQIYNNIRQ....ENEAIA.NnLLTNQLKDESEINKGN...................................--RLDLMMEGKYQFVV..DENYPK......PPI.VLGN.RRLETDD-DL..DAVWDYYDPWAELQVETDISIRLIP--ps...............................................
A5DP43_PICGU/1-98                    ..........................................................MGGYIPPAGSSGS...SSSTPT.G...SSSSSS....TIT-IPd.....................paSL....IP.RnPSVGLKHWGPLVPASDNKMALSMLTTLQVAIGI.LGFHKARV.LRRSNL----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------vamgipntfsr......................................
G8JM33_ERECY/1-368                   ..........................................................MSLFTPPTGGKG-...SSFNRV.P...SKDPEK....PEKDIR.......................sQF....YS.R.PSLGLKFWGPLVPASDNRVGLWSLVTAQTLVGL.FFMCKFRN.LGPK------...................................VIKRDISDFPSLNRFST.TF.GG.MYV..................-----TTHLFPEFG..........GTYSFH.RRVGERTGF.F-.....................................................................---YSKRF.A....NIKRVIYLTTGTVLLAQSMLEASRLTLLEYDPWEEQAKCVRDKQFFNDVVKYYHEGVDP..MR..F..KVRDANSGT....TLS.V.NI.PEVKQGVAVARAQANAENLVTKWLGPL.D.YKPLSFSDFLDKLE.HNLDMYDI...LHHT.N............----.-SKKIIDDTKHa.seRKAELE.F.LTEINRKNRERIRTLL...................................----DSTPSHSIPLSI..KLSDQG.....iRGV.TMDI.TYDSADDIDL..REMWSLHNPWINLALDTSLSIKFLPTV.................................................
K0KJQ3_WICCF/76-128                  ...................................................wrqtsli-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.S....RISKIFSTVTGSYLIFNSGLEISRL-IIPYDPWYEEAKSIRNQ----------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------aia..............................................
G8YP11_PICSO/1-98                    ..........................................................MGVYIPPGSDGGE..gDSSSSG.N...GNGGGT....II---Tip...................npsSF....IP.RnPSIGLKLWGPLVPASDNIPALYMLTGLQIFLGV.LGFHKTRQ.LRSSNLM---...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rmgvpniwq........................................
A0A1E3P7S5_WICAA/80-136              ..................................................iwhqtsfl-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.A....RTSKLLSVVTGGYLIFNSGLEISRL-ILPYDPWYEEAKVSRSKA---------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------ikqgl............................................
C5DZ37_ZYGRC/1-370                   ..........................................................MALYTPPDKSSPP..kAHENEE.D...KGGSNR....EQDDIK........................KF....YV.R.PSLGLRLWGPLVPASDNKMGLWSLIGIQTAVGT.FCLHRIRV.LRASMK----...................................FVSKDIANIPSLNRFSK.TH.GA.MVL..................NPVNNPLKKPLNSN..........------.-------SR.FR.....................................................................QLFSSPRW.S....TFKNVVYLLTGTLLLSQSLLEASRLTILKYDPWYEEAKSVRDKKFFNDIIQFYHEGIDP..TK..V..KVKDATNGN....VMS.T.NI.PEVKQSVALVRAQAEAENPIIKWFGPI.E.YKPMSFTEYLDRME.YHLDIDAL...LHDK.R............TLKE.NQQHLNTQITH....TEGELD.S.IVRHNQEVKERTKDLV...................................----KNAPEGSMALSS.vASQGFP.....lRSV.ILEV.DPQDPDSMDL..NEVWSLYDPWMNLALDTSLSIKFLPTV.................................................
MGR1_LODEL/1-105                     ......................................................mgyi----PPPGDNDDN..gKKSNKK.T...QNTSKP....ISSDSTpdgtti............tiinpmSL....IP.RnPSFGL-IWGPLTPASDNRPAMYTMVALQIAIGV.RFFRYARThLRRH------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------pvpqaqfha........................................
A0A061BBC2_CYBFA/132-276             .................................................ardaakahg-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.-----------------KKVNWWFGPW.D.FKPMSFQEWNKKID.RW-----I...LEQE.G............NATR.QGVALVGSPEI....-GKAYE.K.MREINTNRQSQILSQL...................................RDGSFKETLPHYQTSG..GSSQHPd....rQGV.VFPP.GNELKDDVDL..DEIWAINDPWELLGRDTDMLVRFIP--.................................................
A0A1G4JW00_9SACH/1-368               ..........................................................MGVYLPPDGSKNP...STNLPR.A...SNSGEN....GNDSA-........................KF....YV.R.PSLGLKLWGPLVPASDNRIGLWTLISIQTAVGL.LCMSRFRS.LGNG------...................................IIKKDISQIPSLNRFST.TH.GK.VYM..................-----AAHGPTTFG..........GTHSFR.ISDAGRLSF.--.....................................................................--FNSPRF.M....AIKRSLYLLGGSILLSQSLLETCRLTILKYDPWYEEARSVRDKQFFNDIIKFYHEGVDA..TK..F..KVKDATSGN....VLP.L.NI.PEVKQSVAVARATTEADTWVSQWYGPL.N.FKPMSFSEFLDKIE.YHLEMVDF...LRDK.R............TKDV.AAKLLGKQLHQ....DDAEKI.A.LKKGNKESRERIYELV...................................----KNAPKNSMHQIF..SRPTGA......NGI.MLGP.EVHNADEIDL..SETWSTFSPWLDLALETSLSIKFLPTV.................................................
J5RVD0_SACK1/138-286                 ......................................................piip-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................---RQSRF.I....SMRKLFWGLFGSLLLSQSLLEVTRLNLLKYDPWYDEMKSVRDKKFFNNIVKYYHEGIDP..TK..I..KVKDAMNGT....PLS.T.NI.PEVKQSVALARAQVEAQNPIIKWFGPL.E.YKPMPFNEYLNRME.FHLDMFEF...FQNK.R............NI--.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rgipl............................................
J7S5H4_KAZNA/12-401                  .........................................vppsaqhgmasennggn-------------...---PRE.V...KLDLQH....DDDDAG........................RF....YV.R.PSLGLKLWGPLVPASDNRPALWSLLGVQTAVGI.FCLYRFRK.FALSAR-TAA...................................ALRRDIADLPTLNRFSV.ASpGQ.AFL..................-----------LEG..........AEKQAA.KSASA----.-A.....................................................................GGPRSGRL.P....LVRKALWLVLGTALLSQSMLEFCRLKLLKYDPWAEEARTARDKKFFNDIVRFYYEGVDP..TK..I..KVKDPVSGD....AIS.T.NL.PQVRQSVALVRARAEQLNPVIKWYGPI.E.FKPMSFGEYLDKIE.YFLEMNEL...LTAR.K............RINA.KSLEMLTLLTH....SSGEVE.E.VAQKNAQLRQKIAADQvhieqrts...................elthalepQPEREHEESTSLAVPA..PAKKIE.....lHGI.VLDP.ETDSHKNVDV..AEVWKYYDPWLQLALDTSLSIKFIPTV.................................................
I2GWN9_TETBL/1-394                   ..........................................................MAVYTPPNKST--...DNSSKS.P...TDTTDD....SSRDIE........................KF....YI.R.PSLGLKMWGPLVPASDNKTGLWALVGTQTVIGI.LCVQRFRM.LRLRPISQSTstl............................gfkkLSGRNIADIPSLNRFST.AN.GS.LMT..................------SSKPKIFQ..........LISQFK.LKSSNSYKQ.F-.....................................................................----KTKY.Q....HFSKYIYLLFGSVILFQSSLETLRLTIIKYDPWCEEVKSLRNKKLFNDLIKFYHEGIDP..NK..V..KVKDATSGN....ILS.I.NI.PEVKQSVALVRAQAESQNPIIKWFGPI.Q.YKPMSFSDYLDQLE.FHLDMLES...FQKK.N............SVNE.ASEHLRNQLAN....TDEEIQ.N.FIKKNKENREKALKYVinssnv.......................sfidssDSQPNENSEADITERK..KLRRSN......RSI.ILGP.DKRNITDLDI..PELWTMYNPWTSLALDTSLSIKFLPTV.................................................
G8BE08_CANPC/1-115                   mgvyipppsdnnnndrddskgkhskkstpniptnpltsspssssdsttivipnpksli-------------...------.-...------....------........................--....PH.N.PSVGL-IWGPLTPSSDNRPALAAMVGLQFLLGV.SCFRGARNqLR--------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------hrlvavpnnrp......................................
A0A1E5RI35_9ASCO/1-452               ...........................mglysppdknpgssklregnssngnsdgnss-----------GS...NDNNNN.N...NNNRDN....NSSA-Qn.....................pmLF....TS.R.PSVGLRLWGPLVPASDCTWGMWTLLGIQTAIGF.TLLTKFRV.SLWKYRM-GK...................................TVTKEIADIPSLNRFST.TH.GT.IQYkpenl........lkqvnGTAPVAKNGLNQFG..........GTHTFH.FIHQPTRW-.-Eklv...............................................................gkwKNSMYSRW.M...sHSMRLVYLFSGSILLSLSMLEFSRLVVFDYDPWVEQMKSAREKQFYNDTSRFYREGVDP..SKfeV..KVQDAATGK....FVD.VtSD.PEIRAHVAMARALMVQNSWISKWFGPL.E.VKPLTFKEYLDKIE.QY-EVSK-...LAAE.E............AFKL.IDARLAMPLPE....AVQHLN.T.FALDSENTRKKTLELLhslpanvlpsvss.........iyannplndqpdgK-GAERKTLGQAPKEK.hNSLQLQ......DDIkIFPP.NCKEPQQVRV..GDTWLYNDPWSKLGVETHLGVKIIPS-t................................................
MGR1_ASHGO/1-366                     ..........................................................MALFTPPSED---...-KDGRD.R...SGGGDK....ASGVVR.......................tPF....HL.R.PSLGLALWGPLVPASDNRAGLWTLVGLQTLMGA.FFVSRFRA.LRPK------...................................LLKRDIADFPSLNRFSK.TS.GD.MHV..................----GPVHVFADFG..........GTHSFH.RRAGESPGF.F-.....................................................................---QSRRF.V....SLKRALYLSTGVVLLVQSALESARLTLLVYDPWEEQARGVRDKQFYNDVVRYYHEGVDP..AR..F..IVKDPASGN....TLP.V.NV.PEVKQGVALARAHTNARNIITRWLGPL.D.CKPLSSSEFLDKLE.HYLDTCDF...IQDM.N............NKRL.FGN--PAEVKA....RQKALD.A.LIQANKENRRRIRHIL...................................----DITPPRGLPLSP..KAVDQG.....lRSI.ILDP.DHESTEDLDL..HELWSIYNPWVDLALDTSLSIKFLPTV.................................................
A0A1S7I0U4_9SACH/1-376               ..........................................................MALYTPPDKSSPQ...PRRSEM.E...EDKDGG....TQDDFK........................KF....YV.R.PSLGLRMWGPLVPASDNRMGLWTLVGIQTAVGA.FFLHRIRV.FRASLK----...................................VVKKDISDFPSLNRFST.TH.GD.MFV..................NPARGGASSFFKSS..........ST----.-NGGIGIAR.IG.....................................................................KLFNSPRW.S....TFKNVVYLLTGTLLLSQSLLETSRLTVLKYDPWSEEARSVRDKKFYNDIIQFYHEGVDP..TK..V..KVKDATNGK....VMS.T.NI.PEVKQSVALVRAQAEAANSVIKWFGPL.E.YKPMPFTEYLDRLQ.YHFDIYDF...LQSK.R............TLKE.NAAQLSSQITH....SPSELE.E.YVRYNQETRQRVKDLV...................................----DNVPSGSIPVSP..QTRDLP.....lRGV.VLDA.DQQDADNIDL..EEMWSLYDPWMNLALDTSLSIKFLPTV.................................................
A0A376B9R3_9ASCO/1-451               ..........................................................MGLYSPPDKSSSPpssTDDNIK.N...AKSPND....ADDTET.......................iHF....YN.R.PSIGLRMWGPLVPGSDCRWGLWTLLTIQTFIGY.KFLRKFIK.ITFPYMTSNT...................................TVKRNIADIPSLNRFGG.KV.GDpIYVlqptspnavnpintttttN-------------..........------.NISSATISN.LSrfgagtrninrttinnsrnn.............................ndkhwftftfkknknqnnenNSNTDSKY.T....NFTRVFYFVSGCGLLGQSLLEFLRLTFFDYDPWYEQAKAVREKAFFNDIQKYYREGIDP..TK..IsvKVKDSKTGK....LKD.V.TSdSGVLSSVAIARATMKQSSFLNKWYGPM.D.YKPLSFEEYLDRIE.HFQEYNDS...LHKL.R............GVNElITASITGDHKShgsnLSKELE.K.LHNVNLKARNSTLKLLnnvpan.......................tlgtlqNGDENSTTDSSSFLTF..F--QIN.....dTVK.IIPS.MAKNYTNIEL..SNTWTLNDPWEKLAIETELGIKIIP--ns...............................................
A0A1E5S1I5_HANUV/1-438               ..........................................................MGLYSPPPGDENN...NKNKYHlS...NEDEDN....NDTSIS........................HF....YP.R.PSIGLRLWGPLVPASDCNWGLWLLTGTQLTVGY.YFLRKFRI.SIKEYF-MNK...................................PITKQIKDIPSLNRFSNeSK.GT.IQY..................TKTNHAGGNLINSKtgqmgmgnfgGSQSFH.I--------.-Qrqytkw........................................................eilmnryKKSKAYKYvE....NFKRFGFLLLGTALTSLSILEAMRLLLLDYDPWAEQAKISRDQKFYNDASKFYREGVDPskTR..I..RVKDQGTGK....LVDvT.ND.DSLKRNIALARAGLLQNDWIFEWFGPL.D.LKPLTFNEFLTHIE.HYEINKAA...LIES.R............TKDS.VVHALREEMKN....CKAMEL.G.LFDKNKKNRDLMMSIVeskanignfnansp......lgdvanqlsslnennAINNDNAKNIKYNLGEhvNNLNKS......NVV.ILPP.NARHEDQMSI..IDTWEANEPWTALGLSLDVTVKVVP--ys...............................................
G0W5H6_NAUDC/1-439                   ..........................................................MALYTPPDNSDSS...SNDSKS.Y...GKDNND....ISDDTKk.....................leKF....YS.R.PSLGLRLWGPLVPASDNQNGLWTLITIQTGIGL.FFLYRYRA.LGKHYS---K...................................SIIRDIADVPSLNRFST.TH.GQ.IPLtnn...........ispvNKVSTPNSKLASNTifkg.ktplfGISSFS.KRENPKDTS.SSgvgeprk.......................................................snwngndNFKYSSKF.I....IFKRILYGLTGAIILSQSLLETCRLKILKYDPWLEEAKCVREKKFFNDIIKYYNEGIDP..TK..V..KVKDSMSGN....PVS.T.NI.PEVKQSVALVRAQNEAENPIIKWFGPI.E.YKPMSFTEYLDRLE.YHLDMFDF...FQKK.R............---A.ANALLWNSITH....TTNDLE.E.IIRKNEAARKKICKKFeknkpsahqkhlqd.......llpdppltllpptpSADGEAASSQMLPPTL..NR----......NSI.VLDQ.SLQHSKEIDL..KEFWRLHDPWMNLGLETSLSIKFIPTV.................................................
J8Q7B9_SACAR/1-140                   ..........................................................MAVLTPPSDTNG-...-STDHP.R...SCDHDK....DDNDIK........................KF....YV.R.PSLGLKLWGPLVPAPDNLSGLYTLISIQSAVGL.FALWRLRR.LYKLPPPRRIathtrsdlsfg............elpsemivngktKMKKDIADFPTLNRFSV.TH.GD.IVL..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------apppiip..........................................
A0A367YLV8_9ASCO/1-100               .....................................................mgyip-----PPNDKDEG...TKKNQD.T...NSSSSS....SSSSSTpgstti...........vipnpatLI....PH.N.PKVGL-IWGPLTPASDNRPALYTMIGLQFAIGC.GFFKHARS.LSRL------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rpmggf...........................................
A0A1E4SC56_9ASCO/1-92                ..........................................................MGVYIPPPNDDDN...DKQPSG.S...GSGSSS....SGTTIVip...................npaSW....IP.RnPSVGL-MWGPLTPASDNLPALYFMIGLQVVLGM.VCMRKARH.MW--------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rpvlhrp..........................................
A0A1G4MGP8_LACFM/1-370               ..........................................................MGLYLPPGGSKSP...NASKLG.R...KEDPDD....ANEEGT........................KF....YV.R.PSLGLRLWGPLVPASDNRKGLWTLVAIQTGLGL.LCMKRFRS.IGAK------...................................VIKRDIADFPSLNRFST.TH.GN.MYV..................-----TKHGATTFG..........GTHSFR.RQAGEKTGF.F-.....................................................................---NSPKI.T....ALRRTLYLLSGTLLLSQSLLETCRLTLLKYDPWYEEARSVRDKQFFNDIIKFYHEGVDP..TK..F..KVKDASNGT....VLP.L.NI.PEVKQSVAVARATAQADNFIVEWFGPL.E.YKPMSFSDFLDRLE.YHIDMSDF...LRNK.Q............TQEV.AAELLGKKISH....GQSELE.E.LVERNTKNRERIFALL...................................----LAAPKNSIPQAT..ASHHVE.....sKGV.LLDP.DCRSPEDINL..DEIWSTFNPWMDLALETSLSIKFLPTV.................................................
A0A0H5CCR9_CYBJN/1-83                ......................................mglynprdsgdsnegsgipg-------------...------.-...------....VEKV--........................VF....YQ.R.PSFGLKIWGPFVPASDNLTALYSLTALQTVIGI.TMFRTVRM.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rwrdtsfwgrvtk....................................
A0A1E3QS19_9ASCO/6-79                .....................................................pgses-------------...------.-...--PADR....TSKGKT........................RF....YV.R.PSFGLTLFGPFVPASDCLPGLYGLTAFQLVSAL.GMFYAGRR.IRFR------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------qgfrfkllk........................................
W6MKE3_9ASCO/23-138                  .......................................................shq----TPNSAGTMA...QEVTKE.T...SSDSED....WLTTVT........................RW....KR.R.GDVGLWLWGPLAPAHDATSARKFLTVLQTGFGL.IFFKNAFK.LWRLKS----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------vrgpkrvvpmliniaaggilcynsfyeysyslr................
MGR1_YEAST/1-139                     ..........................................................MAVFTPPSGNSN-...STDHTH.T...QDDHDK....DDNDIK........................KF....YI.R.PSLGLKLWGPLVPAPDNLPGLYTLITIQSAVGF.FALWRLRR.LYKLPPPRRIatgthsdlsfg............elpsemivngktKIKKDIADFPTLNRFST.TH.GD.IVL..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------apppi............................................
J8Q7B9_SACAR/138-386                 .......................................................iip-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................---RQSRF.I....TVRKLIWGLFGSLLLSQSLLELTRLNFLKYDPWYDEMKSVRDKKFFNNIVKYYHEGIDP..TK..I..KVKDAMNGT....PLS.T.NI.PEVKQSVALARAQVEAQNPIIKWFGPL.E.YKPMSFNEYLNRME.FHLDMFEF...FQNK.R............NIRE.NSIELINSISHh.phSSADLE.D.LSESKKLHLQNVEKRL...................................HFLASSRDSIPTPVKK..RSNTVL.....sRGV.ILPH.ETNAPQDIDL..DTITSLYDPWMTLALETSLSIKFIPT-t................................................
J5RVD0_SACK1/1-141                   ..........................................................MAVFTPPPDT-NS...APDHPQ.S...QDIHDK....DDNDVK........................KF....YI.R.PSLGLKLWGPLVPAPDNLSGLYTLISIQSAVGL.FALFRLRR.LYRLPPPRRIathahsdlsfg............elpsemivngktKIRKDIADFPTLNRFST.TH.GD.IVL..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------apppiip..........................................
A0A1E4REW8_9ASCO/1-118               ...........................mgvyipppsesgsssddkedkkgqsknssdt-------------...------.-...------....-----NtstdssltissestdtsrvesfirKY....IPeN.PSFGLIFWGPFKPAPDNRPALYICTGTQLIASG.ILFNNFRK.LRRYPQ----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------lsgpdkymk........................................
A0A421JFQ0_9ASCO/1-98                ..........................................................MGGYIPPAGSSGS...SSTPSG.S...SGSSSTi..vIPDPIS........................LI....PR.N.PSVGLKHWGPLVPASDNKMALSMLTTLQVAIGI.LGFHKARV.LRRSNL----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------lakgipnsvgrr.....................................
C4YB94_CLAL4/9-95                    ......................................................flsa------PTSSSSS...AGASQS.S...PTAAAS....EPRPFA........................LF....PR.N.PSVGLRLLTPLVPASDNTPALAALTTAQLLFGI.GLMAR---.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rpvrigevvwrarv...................................
G3AMP5_SPAPN/1-107                   ..........................................................MGVYVPPPDDNDPk.kNQNQKN.S...NSSPAS....GSNSSSspsgstt..........iiipnpvAL....IP.RnPSVGL-IWGPLMPASDNRPALYASIGAQFLLGL.AMFRHARG.LFRL------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------qpiatglnt........................................
A0A1G4JZB9_9SACH/1-372               ..........................................................MGLYSPPDGSKNP...NRSKLV.Q...KEDPEK....PSEDKT.......................iEF....YA.R.PSLGLRLWGPLVPASDNRTGLWSLVGIQTLFGL.YCMRKFRL.SGSQ------...................................FSKRDISEFPSLNRFST.SR.GK.IYV..................-----TNHTGTTFG..........GTHSFH.RTGPTGSTS.--.....................................................................-FFNSAKF.T....IFKRSMFLLCGSVLLSQSLLEACRLTILKYDPWYEEARSVREKQFFNDIIKYYHEGIDP..TK..F..RVKDAVNGN....VLP.L.NT.PEVKQSVAFARAAVEADNWIVSWFGPL.E.YKPMSFTEYLDRLE.YHLEMTDF...FSKR.H............TKDV.TNQLLGRAIAH....GPEEVE.E.LKKQNAQVRENVHSLM...................................----ESAPKHSIPVTN..GSRQGT.....lKGI.IFDP.NLRAPEEIDL..FETWSTFNPWLDLALETSLSIKFLPTV.................................................
A0A0C7ND35_9SACH/1-372               ..........................................................MGLYSPPDGSKNP...NLSKIA.H...KEDPEK....PDDDKS.......................iQF....YP.R.PSLGLRLWGPLVPASDNRTGLWTLVGIQTAIGL.FCFKRFRT.LGSK------...................................IVKRDISEFPSLNRFST.SR.GD.IYM..................-----GTHLGTSFG..........GTHSFQ.RIGREGPSR.--.....................................................................-FFQSAKF.N....AFKRTIYLLSGSLLLSQSLLETCRLSILKYDPWYEEARSVREKQFFNDIVRYYHEGIDP..TR..F..KVKDAVNGN....VLP.L.NT.PEVKQSVALARATVEADSYLISWFGPL.E.YKPMTFTEYLDKLE.YHLEMTDF...IRNR.H............TKET.TTLLLGRAVSH....KKQELQ.D.LIKKNSQTKQLVHSLM...................................----ESAPKHSMPVSN..GPRQTA.....fKGL.IFDS.SLQDPQDIDL..AETWSAFNPWLDLALETSLSIKFLPTV.................................................
A0A367XR92_9ASCO/1-101               ...........................mgyipppndkdegtkknrdtnstssssssss-------------...------.-...------....-----Stpgstti..........vipnpatLI....PH.N.PKVGL-IWGPLTPASDNRPALYTMIGLQFAIGC.GFFKHARS.LSRL------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rpmggf...........................................
MGR1_KLULA/2-351                     .................................................aiytsgtqs-------------...------.-...-DNSE-....PVGNDP........................KF....YT.R.PSLGLKLWGPLVPSSDNTTGLWSLVAIQTGLGL.FLMQRFRK.LGKK------...................................WVKRDIADFPSLNRFST.TH.GD.MYM..................-----TRHIPVQFG..........GTHSFN.IRVGTRTGF.W-.....................................................................---YSERF.R....TIRRVTYLLAGTLILSQSMLEVSRLTLLKYDPWVEEAKSVREKQFFNDIVKYYHEGVDS..TK..F..KAKDELSGQ....SIS.L.NL.PEVKQSIAVARAQAQAENLVTKWFGPL.D.YKPQSFSEFLDKLE.YYLNMTDF...LNNL.R............-RQK.KNDKINS----....---QLV.K.LEEENKRNRQRIHTLM...................................----AHAPARAIRTNQ..EVQDIYa....iRKV.LLHH.DTESPNDIPL..TEIWAIYNPWTNLALDTALSIKFFPSV.................................................
G8ZQS5_TORDC/1-395                   ..........................................................MALYTPPGKSPSR...PQAKEN.E...NDKKDD....PKDDIS........................KF....YV.R.PSLGLRLWGPLVPASDNKVGLWSLIGIQSAVGI.FCMYRIRR.LRGSLN----...................................TVRKNIADIPSLNRFST.TQ.GE.LVM..................PPPSLTGSAPTTFT..........AGHGVQ.KASYGGTAF.GGassffks.......................................................sskengkSGFKFASF.M....TFKQVIYLLTGTLLLSQSLLEACRLTILKYDPWAEEARSVRDKKFFNDIIKFYHEGIDP..TK..V..RVKDASSGN....VMP.T.NI.PEVKQSVALVRAQAEAENPIIKWYGPL.E.YKPMSFSEYLDKLE.YHLEMIVF...LQED.K............KAKE.TAMEIMHKITY....SATEVE.E.LGKKNVENRKKAYELV...................................----TNAHKGSIPLSD..KVQTYP.....mRGV.LMET.DNQSPEDFDL..EEMWNLYDPWMNLALDTSLSIKFLPTV.................................................
MGR1_CANGA/1-445                     ..........................................................MGIFTPPGKSDKRd.aNEEKPT.L...LGSNSK....DETDVE........................KF....WV.R.PSLGLKLWGPLVPASDNKTGLWTLVAVQSMVGL.LCFYRFKS.LRIIDRNGALnsvgksgirptsvlvnepklynsaftqqeavsgkpLVKKDIADFPTLNRFST.TH.GD.MFV..................NTTNVNRNTPSLSA..........APVVAS.PVLSSAGHQ.SEimakse.........................................................aknnwkSFFKSDNW.L....IFKKVFYLLAGSIILSQSMLEACRLTILRYDPWCEEAKTVREKKFFNNIVKFYHEGIDP..TK..V..KVKDAVSGN....IMP.T.NV.PEVRQSVALVRAQTEAENPIISWFGPI.E.YKPMTFSEFLDRLE.YHLDMFEY...FQGK.R............AANE.TALGFLTGIKT....---ETS.N.LRDQNAQNRSRILKELkse............................dqlsNDLSIKTGNAKIPKGT..QRHGFSaa..anRSI.ILEE.DVAVPEDIDL..NEIWTLYDPWLNLALETSLSIKFIPTV.................................................
A0A4V1J3P2_9ASCO/25-115              ......................akahgrhsssekdgskgpgssstdspssfwlldlfl-------------...------.-...------....------........................DL....FP.RnPSVGLRFLTPIVPAADNRPALYMVTTAQLLLGL.QWMTRR--.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------vpriaesrfr.......................................
A0A1D2VMG2_9ASCO/34-136              ..............................................snpnsnsnsnsn----------SNPd.sASNSAS.N...SQNAAN....HLETHR........................KM....YS.R.PSLGLFLFGPLVPAPDCKNCILFLSSLQSLIGL.GFITIGRN.LYKKNLVINN...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------yqkrffprlik......................................
C4R0B9_KOMPG/6-89                    .................................................pddgkqsgg-------------...------.-...--QPNR....RAKVLS........................RFlppeHQ.R.PSIGLF-LGPFTPAADNEIALWTCIGAQLFSGL.ALLRMSRR.FVF-------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------spdqsvrrflfkt....................................
C5DK18_LACTC/47-417                  ..........................................................MGLYSPPDGSKAP...NAPALA.Q...KEAPDK....PNDGAL.......................iKF....YP.R.PSLGLRFWGPLVPASDNREGLWTLVGIQTVFGL.LCLRRSRS.IGSS------...................................IVKREISKIPSLNRFSV.TR.GS.MYV..................-----SEHGPTAFG..........STNSFS.RRGSNLWGF.L-.....................................................................---RSTKF.I....ALRKSLYLVGGTLLLSQSLLEACRLQILKYDPWYEEARSVREKQFFNNIIKYYHEGIDP..TK..F..KVKDASNGA....VLP.L.SS.PEVKQSVAFARATLEADSWFTSWFGPI.E.YKPMSFTEYLDRLE.YHLEMTDF...IRNG.R............NNDA.ASQLLGRPLSH....GTAELE.E.LIQKNRSSRKKIGNLM...................................----ESAPRQSMPVVS..GQRQSS.....lKGI.LLDP.NIQSSEDIDL..DETWSAFNPWLDLALETSLSIKFLPTV.................................................
A0A2T0FM18_9ASCO/1-55                ........................................................mk-------------...------.-...------....EDADPN........................KW....YP.N.PSVGLNVWGPLVPANDCKPCMAFMVGMQFVTGAaFCF-----.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------fpgrr............................................
G8YLN3_PICSO/1-100                   ..........................................................MGVYIPPGSDGGE...GDSSNS.G...NGNGGG....GGTIITip...................npsSF....IP.RnPSIGLKLWGPLVPASDNSPALYMLTGLQIFLGV.LGFHKARQ.LRSSNLM---...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rmgvpniwq........................................
C5M5R4_CANTT/1-106                   .......................................mgyipppndkdeankknqd-------------...------.N...SNNSNT....SSSSSSssssstpgs.....ttiiipnpatLI....PH.N.PKIGL-IWGPLTPASDNLPALYSMIGLQFILGC.GFFKHART.LSRL------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------rpmggf...........................................
G3BFN9_CANTC/1-96                    ..........................................................MGVYIPPNNNNGD...QSGDQ-.N...GG-NPR....KPTPVElfl.................reklNF....GT.N.PSFGLHFWGPLVPPPDNRTALKALTAAQFFLGL.GLISRSFA.LRSSR-----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------llrngrvp.........................................
H2ATH6_KAZAF/1-111                   ..........................................................MAVYTPSGNNNNS...GINDND.V...G-----....SASEME........................KF....FV.R.PSLGLKLWGPLVPASDNRTGLWTLLTIQTVVGI.GCFKRFNS.LRRAHQ----...................................VIKTNISRLPTLNRFSK.TD.KI.ISI..................E-------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------skplqkl..........................................
M3JFK7_CANMX/1-115                   ..........................................................MGVYIPPPNDKDE..gDKKNVS.K...NSNSNS....SSSSSSsssspgst.......timipnpagLI....PH.N.PKVGL-IWGPLTPASDNRPALFSMIGLQFIIGC.GFFKHART.LSRLR-----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------pmggyqvpnvapkmv..................................
MGR1_YEAST/139-388                   .......................................................iip-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................---RQSRF.V....SVRKLLWGLFGSLLLSQSLLELTRLNFLKYDPWCDEMKSVRDKKFFNNIVKYYHEGIDP..TK..I..KVKDAMNGT....PLS.T.NI.PEVKQSVALARAQVEAQNPIIKWFGPL.E.YKPMSFNEYLNRME.FHLDMFEF...FQNK.R............NIRE.NSIELINSISHnpqsSSTGLE.G.LSESKKLHLQNVEKRL...................................HFLASSGDSISAPVKK..RSSTTL.....sRGV.ILPH.DTKGPQDIDL..DTIRSLYDPWMTLALETSLSIKFIPT-t................................................
A0A1E4TZS5_PACTA/5-79                .....................................................lpkgn-------------...------.-...---ESN....DKDKTP........................IF....YA.R.PTVGLGFWGPLVPAPDNKTAILILSGVQFGLGL.LMF-KFAR.INWNT-----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------knrywtvrfrk......................................
MGR1_LODEL/100-186                   ..........................................qaqfhappglgvnsmi-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........-----S.TTANQTYSApPQ.....................................................................QFLRRSKG.D....VFKSILAITTGSLLIFGSGLEIARM-MLPYDPWYDEAQFYRKQA---------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------vrngdk...........................................
A7TFE5_VANPO/1-470                   ..........................................................MALYTPPEKSDNSg.qASTSTK.K...GNEGDD....LDD-SK........................RF....FV.R.PSIGLKMWGPLVPASDNRAGLWTLIGLQTGIGV.LCMIRFRQ.LRKLNTISKN...................................VIKKDIAEIPSLNRFSQ.SH.GT.VYVpkpm.........memsgNTAASPNSAAISNS..........GATTIS.NIETQNISN.NNsntidtgsndsnnknnniaasnaetntnspamaasttlpintaaysslnvvsqglnnkgfqgsegkwrySSSRSSRF.G....NFKSFMFFLAGSVVLFQSFLEAARMTLLKYDPWREEAKSVREKKFFNDIILFYHEGIDP..TK..I..KVKDAASGN....ALS.T.NI.PQVKQSVALVRAQAEAENPIIKWYGPL.D.YKPMSFNDFLDRLE.FQLDMRVS...LDNR.R............-STA.VSKSFTSQFKH....TEEELD.S.LINNNEKNRQLTLEGKlsppkn.......................nsvpefDVIKENTKDGTI----..-----P.....lRGI.VFQH.EQTSPDDIDL..EETWSLYNPWMNLALDTSLSIKFLPTV.................................................
A0A1E3QS19_9ASCO/113-264             .............................................rarleaeargerp-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.--------------------SWWFGPL.N.WKPIPYKQYSAEMD.RWITNAET...SNGI.G...........eHLEA.VQASRNHTFTK....MYAGIR.E.LNKKKAAELLATDEYR...................................-NVTEETKSTRVKNLN..LNNTYV......RAN.IELG.KVEINNEADF..LLVWGQLEPWENFALETDISLRFIP--qr...............................................
MGR1_DEBHA/1-92                      ..........................................................MGVYIPPGSGGND...NGKSGG.S...GDNTLT....IPNPAS........................FI....PQ.N.PSLGLRLWGPLVPASDNLPALYFLTSLQIGIGL.LSFNKVRY.LRRSNL----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------arfgient.........................................
A0A1B7TCH9_9ASCO/1-391               ..........................................................MGLYTPPPGEENH...NKPKIE.KvdpKEHDDD....NNNSNI........................LF....YS.R.PSIGLRLWGPLVPASDCNWGLWLLTGTQITVGY.IFLRRFRV.SMKNYF-MNR...................................PITKQIKDIPSLNRFSQdST.GT.IQF..................-----TKQSNGHFG..........GAQTFHiQRSPSKLEL.FT.....................................................................NKYKSSKW.YkyigHLTRFTYLLLGSVLTSLAVLEAMRLLLLDYDPWAEQAKAAREQQFYNDANQYYREGIDPskTR..I..RVKDPSSGK....LIDiT.ND.DSLRSNIAMARAGVLHNKFFFEWFGPV.N.MKPFDFNEFLTFIE.QY-EMNKE...AMKE.A............ILAN.PKRLLKEQDLQ....NCKKLElA.LDKQNRDNRETFLNMG...................................---TKTLGHQMAGTVS..NTTNSS......PVV.ILPP.NARDPDHMAF..IDTWETNEPWNRLGLDIHMSARFIPS-s................................................
A0A1E3P7S5_WICAA/1-91                ..........................................................MGLFIPPNSDRNN...NNNSKN.P...ANPKED....NQDDSK.......................iIF....FT.R.PSVGLKVWGPLVPASDCLPCLYGLTAFQTMMGL.IMFRHTRI.IWHQ------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------tsflarts.........................................
A0A1E3P7S5_WICAA/139-273             ........................................................nf-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.----------------------WFGPI.D.YKPMSFKEWSSKVD.TWVEETET...QINH.Q............----.ESPTFAMQNHQ....IHSIYQ.Q.LRALNKQHNQDILKNL...................................KMPGFKDMLPNFQSFT..NPEFDR......PQV.VIPK.GNELKDDIDF..LEAWELNDPWESLARDTEYEVRFIP--kf...............................................
A0A1E3PIS1_9ASCO/4-85                ..................................................fpssspsp-------------...-----T.S...TSKSAK....DTTSKW........................PY....YQ.Q.PSFGLALWGPLVPASDCKSCLYTLVLTQMSLGV.YM------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------qftpprrwfrniwafrasrv.............................
A0A1X7R3P6_9SACH/1-406               ..........................................................MAIYSPSNNDD--...---DKD.D...IKSNQE....PPQQTE........................RF....YV.R.PSLGLKLWGPLVPASDNRTGLWTLVGIQTALGL.LCFHRFRK.LVNRSLLTVAnkakk.........................egemfNTVKNIADIPTLNRFST.TH.KV.LVM..................NNLPLAQQTATN--..........------.---------.-G.....................................................................GTSGKSKF.S....MLRKVLYLISGTALLSQSMLEFCRLKVLKYDPWYEEARTARDKKFFNDIMKFYHEGIDP..NE..V..KVKDVTSGN....IMS.T.NI.PEVRQSVALIRAQAESQNPIIRWYGPI.E.FKPMSFSDYLDQME.YYLEMNDL...LLKK.KqfkkkssspsdtNNSS.GPVSLLSLISH....TDEEYQ.E.IKKQNKKINDDVLKNTfnvtrsenq.................evqdaesnsS-----GNSPHVPEYQ..RRTATSdltvpvRGV.TLDP.KLTDPQQINL..EEVWALYDPWMSLGLDTSLSIKFIPTV.................................................
A0A1E4REW8_9ASCO/155-314             ................................................rlaikngskp-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.--------------------TWWWGAIrQ.YKPMSFNTWLD--E.FSKDTYHQ...ILHR.Qiy.......enpELHQ.KTTPLPDND-K....FKEAYE.H.IKGRNDKASHDSLEGElkdv..........................nelnkASRLDDLMEGKGKVQL..NEHYAK......SPI.QLGN.HSIES-DDDL..ELVWYNFEPWDELKSDTTYDVRLIP--kc...............................................
MGR1_PICST/61-127                    ..................................................npstwiph-------------...------.-...------....------........................--....--.N.PSAGL-IWGPLTPSSDNRPALYGMVGLQFILGL.GFFRAARQ.LYRPRT----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------ivtsvnsipqhf.....................................
A0A1L0BHX6_9ASCO/42-125              ...........................................pltlppdkssvhgdi-------------...------.-...-SSTDL....PGSHEQ........................SF....IP.RnPSVGLRLFTPLVPASDNKPALFLVSTFQLLMGL.TLMTR---.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------riprigespfwart...................................
A0A1A0HH81_9ASCO/1-60                ......................................................slfp-------------...------.-...------....------........................--....-T.N.PSLGLFLFSPLVPAADNRPALALLTTVQLLLGL.SWMTRR--.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------apragesrararava..................................
C5M5R4_CANTT/161-348                 ..............................................rmaikngdkpsl-------------...------.-...------....------........................--....--.-.---------------------------------.--------.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.----------------------WFGAY.QyYKPMDFKTWINKVE.DWIKNVEKeieIEDS.N............NFAN.LSVELGKNINV....LNTTGI.N.TTGTNQIQTGGVLHKLnnkgkyleiyhrlrdn..nktrwnellqgdlkdvdELNKAQRLDDIMEGKT..NLINPNf...nkSSI.ILGN.H-RMDDDDQF..EMVWLNFEPWDELKLDTEYDIRLIPS-t................................................
A0A061BBC2_CYBFA/1-92                ..........................................................MGLYIPPTGGSSG...NSSNSS.G...GKSDGQggifPTGSTTk......................iIF....YS.R.PSVGLKIWGPLVPASDNLIALYGLTAFQGLFGL.MMLRTVRR.----------...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------kwpdttfk.........................................
A0A421JVF9_9ASCO/1-119               ..................................mgvyvpppddndpkknqnqkdsts-----PTSNSSNS...SST---.-...------....---DSSssasgsn.........tiiipnpvTL....IP.RnPSVGL-IWGPLIPASDNRPALYATTGLQFLLGV.AMFRHARS.LLRIQ-----...................................-----------------.--.--.---..................--------------..........------.---------.--.....................................................................--------.-....-----------------------------------------------------------..--..-..---------....---.-.--.---------------------------.-.--------------.--------...----.-............----.-----------....------.-.----------------...................................----------------..------......---.----.----------..---------------------------piatglntppvmarr..................................
#=GC seq_cons                        .........................................................................................tt......p............................h....h..p.PSlGLhhWGPLVPASDNp.uLahlhuhQhhlGh.hhht+hR..h..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
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