GenomeNet

Database: Pfam
Entry: MtrF
LinkDB: MtrF
Original site: MtrF 
#=GF ID   MtrF
#=GF AC   PF09472.13
#=GF DE   Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)
#=GF AU   TIGRFAMs;
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   TIGRFAMs
#=GF GA   22.00 22.00;
#=GF TC   22.00 22.90;
#=GF NC   21.40 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR013347;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Many archaea have evolved energy-yielding pathways marked by
#=GF CC   one-carbon biochemistry featuring novel cofactors and enzymes.
#=GF CC   This domain is mostly found in MtrF, where it covers the entire
#=GF CC   length of the protein. This polypeptide is one of eight subunits
#=GF CC   of the N5-methyltetrahydromethanopterin: coenzyme M
#=GF CC   methyltransferase complex found in methanogenic archaea. This is
#=GF CC   a membrane-associated enzyme complex that uses methyl-transfer
#=GF CC   reactions to drive a sodium-ion pump. MtrF itself is involved in
#=GF CC   the transfer of the methyl group from
#=GF CC   N5-methyltetrahydromethanopterin to coenzyme M. Subsequently,
#=GF CC   methane is produced by two-electron reduction of the methyl
#=GF CC   moiety in methyl-coenzyme M by another enzyme, methyl-coenzyme M
#=GF CC   reductase. In some organisms this domain is found at the C
#=GF CC   terminal region of what appears to be a fusion of the MtrA and
#=GF CC   MtrF proteins. The function of these proteins is unknown, though
#=GF CC   it is likely that they are involved in C1 metabolism.
#=GF SQ   59
#=GS MTRF_METAC/10-72          AC Q8TU04.1
#=GS H1YXH3_9EURY/9-66         AC H1YXH3.1
#=GS A0A1D3L4Q6_9EURY/182-238  AC A0A1D3L4Q6.1
#=GS D1YVZ4_METPS/6-67         AC D1YVZ4.1
#=GS D3E044_METRM/1-63         AC D3E044.1
#=GS D5E7Y8_METMS/9-71         AC D5E7Y8.1
#=GS D7EBK8_METEZ/10-72        AC D7EBK8.1
#=GS MTRF_METMA/8-70           AC P80654.4
#=GS Q12VU9_METBU/10-72        AC Q12VU9.1
#=GS MTRF_METTH/1-62           AC O27226.1
#=GS MTRF_METJA/2-63           AC Q58262.1
#=GS F7XQ95_METZD/9-71         AC F7XQ95.1
#=GS G7WPT8_METH6/27-88        AC G7WPT8.1
#=GS E1RDW8_METP4/10-66        AC E1RDW8.1
#=GS B8GE99_METPE/5-66         AC B8GE99.1
#=GS L0HIK8_METFS/6-65         AC L0HIK8.1
#=GS A0A4E0QT31_9EURY/9-71     AC A0A4E0QT31.1
#=GS A0A062VAV6_9EURY/171-231  AC A0A062VAV6.1
#=GS A0A2V3JCJ5_9EURY/185-246  AC A0A2V3JCJ5.1
#=GS I7LK65_METBM/5-66         AC I7LK65.1
#=GS A0A2V3JJD2_9EURY/43-104   AC A0A2V3JJD2.1
#=GS A0A162FL45_9EURY/1-63     AC A0A162FL45.1
#=GS A0A484F6Z2_9EURY/4-60     AC A0A484F6Z2.1
#=GS MTRF_METKA/12-73          AC Q8TVA7.1
#=GS R9SMM2_9EURY/1-63         AC R9SMM2.1
#=GS A0A1D2WBH5_9EURY/1-61     AC A0A1D2WBH5.1
#=GS A0A2U1S6S6_9EURY/1-63     AC A0A2U1S6S6.1
#=GS A2STR3_METLZ/3-60         AC A2STR3.1
#=GS A0A366M8K6_9EURY/1-63     AC A0A366M8K6.1
#=GS W9DQI1_METTI/9-71         AC W9DQI1.1
#=GS A0A498GZ13_9EURY/5-66     AC A0A498GZ13.1
#=GS A0A0X3BPR4_9EURY/5-66     AC A0A0X3BPR4.1
#=GS L0KXS0_METHD/10-72        AC L0KXS0.1
#=GS A0B8Y1_METTP/11-72        AC A0B8Y1.1
#=GS U6EEB8_9EURY/1-61         AC U6EEB8.1
#=GS A0A2Z4L8P1_9EURY/1-57     AC A0A2Z4L8P1.1
#=GS A0A1D3L4H5_9EURY/1-61     AC A0A1D3L4H5.1
#=GS F6BEA3_METIK/187-248      AC F6BEA3.1
#=GS A0A1V6N4J2_9EURY/1-63     AC A0A1V6N4J2.1
#=GS A0A166CFC4_9EURY/1-63     AC A0A166CFC4.1
#=GS Q2FRM9_METHJ/1-53         AC Q2FRM9.1
#=GS F0T8R9_METLA/1-61         AC F0T8R9.1
#=GS A0A062UZY6_9EURY/4-66     AC A0A062UZY6.1
#=GS A0A062V836_9EURY/11-72    AC A0A062V836.1
#=GS E3GZ45_METFV/2-63         AC E3GZ45.1
#=GS D7DUI1_METV3/188-249      AC D7DUI1.1
#=GS A0A483CSG6_9EURY/7-66     AC A0A483CSG6.1
#=GS A0A328PIJ7_9EURY/1-63     AC A0A328PIJ7.1
#=GS Q6LWY9_METMP/187-248      AC Q6LWY9.1
#=GS A7I5S5_METB6/6-65         AC A7I5S5.1
#=GS A0A2V3JGN7_9EURY/9-67     AC A0A2V3JGN7.1
#=GS A0A328SP31_9EURY/1-57     AC A0A328SP31.1
#=GS A6UWH8_META3/189-250      AC A6UWH8.1
#=GS F4BZJ1_METSG/10-71        AC F4BZJ1.1
#=GS A0A2V2N2Z2_9EURY/6-64     AC A0A2V2N2Z2.1
#=GS A0A166F2N7_9EURY/1-63     AC A0A166F2N7.1
#=GS Q2NI28_METST/2-55         AC Q2NI28.1
#=GS Q0W333_METAR/184-244      AC Q0W333.1
#=GS A0A328S3B6_9EURY/1-57     AC A0A328S3B6.1
MTRF_METAC/10-72                     ...........GVPMVLNPQMGAIDATVESIRYRAQLIARNQKLDSGVMSTGIIG.FAAGFLFSLLMVIiLPLM-a....
H1YXH3_9EURY/9-66                    .........pa------TIRMAAIKDMMEDIEFKAQVLARTNKLESSIMTSGGVG.FGVGLIISLVLVL.VPVFL.....
A0A1D3L4Q6_9EURY/182-238             ........kpv------APETALIDARIRNIQTQVKMIGANQRIFAGMYAGKVQG.LVIGLAFILTL--.-----gtill
D1YVZ4_METPS/6-67                    .....avaatq------APPESAFVPMIDEICYRAQLTARNQKLSSAVGATKVLG.FLIGALFALGMVL.IPLAL.....
D3E044_METRM/1-63                    ...........MVRFSNKPNTRGIRNASNNVEYRAKLLGREGRLFAGVISTRFSG.MAIGIGLALALAVvIPYL-a....
D5E7Y8_METMS/9-71                    ...........GVPMVIEPKMGAIDRVVEDIRYRAQLISRSQKLDSGVSAAGIVG.FTIGFLFALIMVIiLPLLV.....
D7EBK8_METEZ/10-72                   ...........GVPKVINPLMGPIESVVEKIRYRGQLIARNQKLDSGVSATGTIG.FAIGFIITMILTLvIPFLV.....
MTRF_METMA/8-70                      ...........GVPMVLAPQMGAIDATVESIRYRAQLIARNQKLDSGVAATGIIG.FAAGFLFSLLMVIvLPVAV.....
Q12VU9_METBU/10-72                   ...........GVPMVINPQMGAIENVVDRIRYRAQLIARNQKLDSGVNATAATG.FIVGFGFAVLMVLiLPLII.....
MTRF_METTH/1-62                      ...........MIILSNKPNIRGIKRVVEDIKYRNQLIGRDGRLFAGLIATRISG.IAIGFLLAVLLVG.VPAMM.....
MTRF_METJA/2-63                      ...........GVEVSNKPNVSSIQSYVEDLEYKVGLITRNRGLESGTESAGTKG.LIIGVVSAIVLMG.IPLAL.....
F7XQ95_METZD/9-71                    ...........GVPTIVNPQMGTVESTVKSIEYRAQLIARNQKLDSGVGAASMVG.FSIGFVLALLFVIiLPVII.....
G7WPT8_METH6/27-88                   ...........GLPTVLAPFMGPFDQITDSVLYRAQLVVRDQKLSSGVNAAMPIG.AVVGFLFAILMVL.LPVYI.....
E1RDW8_METP4/10-66                   ........tii--------RTAAIEAMVADMRYKGQILARTNKLESGIMDSGIIG.FMFGLLITLALTI.VPVYL.....
B8GE99_METPE/5-66                    ........gsk---AAGPIRMVAINNMVENMRYKSQILARTNKLESGIMDSGLVG.FAAGMLVALVLIV.VPALV.....
L0HIK8_METFS/6-65                    .......kstg------PVRMVAIDNMVENIRYKSQILARTNKIDSAVTASGLVG.FVAGLLTALILIV.LPVLL.....
A0A4E0QT31_9EURY/9-71                ...........GVPMVINPNMGPIEAVVEDIRYRAQLIARNQKLDSGVSATGISG.FLAGFVFILLMTIiLPMV-i....
A0A062VAV6_9EURY/171-231             .........gv---TTVSPELVAIEARVRAIEGEVKDLGKVQKVMSGLTSGLFQG.FVAGFVVTLVLFA.I----mrll.
A0A2V3JCJ5_9EURY/185-246             ....iplanpa------MPFMGVIAPAVESIRYKSQMLARDYKLSMAISKNSLIG.IITGLIMALIV-S.LPF--iy...
I7LK65_METBM/5-66                    ...........GIQTAGPIRMTAINRMMDSIRYKAQILARTTKLESGIMGSGILG.FAAGIIVAMLLIV.IPVLI.....
A0A2V3JJD2_9EURY/43-104              ...........GTPMVIEPFMEPFEAAVESVRRRAQLIARNQKLDSGFTAGAPLG.VAAGILFALILVL.LPLL-w....
A0A162FL45_9EURY/1-63                ...........MVKFSNKPNVRGIKSVTEDTKYKSQLIGREGRLFAGLISTRVTG.ITYGLLIAFVLVVvIPFLV.....
A0A484F6Z2_9EURY/4-60                ......qeirn-----------NLDELVSSISYRSQLISRAQKLDSGIITTRRIG.FIAGFLTAVVFVLvIPLII.....
MTRF_METKA/12-73                     iigapamadtd-----------RADTYVNDVRDSSQFFGRDARLYFGLNVNRFAG.LACGMVFAGVLLV.-PL--lll..
R9SMM2_9EURY/1-63                    ...........MVQISNKPNVRGLKNTADDIEYSSKLIGREGRAYAALSFTRTKG.IGIGVTIAFVLLIlLPYI-a....
A0A1D2WBH5_9EURY/1-61                .........ml---ISNKPNVRGIRKVAEDVKYRAGLIGRDQRLFAGLMATRIQG.MVMGFILAILLVG.LPIL-w....
A0A2U1S6S6_9EURY/1-63                ...........MVKISNKPNVNGINNVSEDVDYSAKLIAREGKLFAGLINTRFKG.FAYGIILALVLIViIPAI-a....
A2STR3_METLZ/3-60                    ........gsi-------IRMAAIDKMVDNIRYKGQILARTNKVDSAISSSGLVG.FAAGLVLALVLIL.VPVLV.....
A0A366M8K6_9EURY/1-63                ...........MVKLSNKPNVRGIKNVSEDVKYRSQLIGREGRLFAGLISTRFTG.IGLGLAIAFVLIVvIPYL-a....
W9DQI1_METTI/9-71                    ...........GVPMVITPQMGPIEAVVEDIRYRAQLIARNQKLDSGVSATGVAG.FVAGFIFAIVMVViIPM--fa...
A0A498GZ13_9EURY/5-66                ........gnk---AAGPIRMAAIDRSMNNIRYKAQIMARTNKLESGIQSGGLVG.FAAGILAAMVLIL.VPAV-f....
A0A0X3BPR4_9EURY/5-66                ...........GIQTAGPIRMTAINRMMDSIRYKAQILARTTKLESGIMGSGILG.FAIGIIVAMLLIV.IPVLI.....
L0KXS0_METHD/10-72                   ...........GVPMVISPQMGPIDNVVADIRARAQLIARNQKLDSGVSATGFIG.FAAGFIFAILMAVvLPLII.....
A0B8Y1_METTP/11-72                   ...........GTPAVIEPAMPLFDQIVDDIKYKAQLLARETKLSSGVIAAAPQG.FAIGFFLAVAMVL.GPFLL.....
U6EEB8_9EURY/1-61                    .........ml---ISNKPNIRGIKKVAADVKYRTQLIGRDQRLFSGLIATRIYG.MAIGFILAALLIG.IPVI-w....
A0A2Z4L8P1_9EURY/1-57                ........mrk--------NIEHINDLTNTIEYKTQLIGRNERLTSGVRETRLKG.ILIGFILTCIVIL.LPIL-y....
A0A1D3L4H5_9EURY/1-61                .........ml---ISNKPNVKGIKKTVEDIRYRTQLIGRDQRLFAGLINTRVYG.MAIGFVFAMLLVG.LPVL-w....
F6BEA3_METIK/187-248                 ...........GIPTVVEPDLEACQKLLEKLEYKVGLMTRDIGLASGVSSESVKG.FAIGSLLAVVLVG.IPIIL.....
A0A1V6N4J2_9EURY/1-63                ...........MVKLSNKPNVRGIKNVSEDIQYRSQLIGREGRLFAGLISTRFTG.IGLGIAIAFLLVVvIPYI-a....
A0A166CFC4_9EURY/1-63                ...........MVKFSNKPNIKGIRNTAEDTNYKAKLIGREGRLFAGLNATRITG.IAYGLILAFVLVIiIPLL-a....
Q2FRM9_METHJ/1-53                    ...........---------MAAIDAMMADMKYKGQILARTNKLESGIMGAGIIG.FAIGLAFALILVVpV----ilm..
F0T8R9_METLA/1-61                    .........mi---LSNKPNVRGIKSTVKDIKYRTGLIGRDQRLFAGLITTRVYG.MAVGFIFALLLVG.LPVI-y....
A0A062UZY6_9EURY/4-66                ..........k-IPLLVSPNARELNRMVSELERRVMIIGRDQRTFSGIFNLRARAyFVFGFLLALGLVF.LAMV-m....
A0A062V836_9EURY/11-72               ...........GVPMVVTPSMAAIESMIEDLRYRGQLIARNQKLESGVGSTGVIG.FIIGFFIVMMMVL.VPVL-r....
E3GZ45_METFV/2-63                    ..........a-ISLSNKPNIKGVKKTTDDICYRVQLIAREGRVFSGLIQTRIPG.LIYGILLAVILIGiVA---vf...
D7DUI1_METV3/188-249                 ...........GIPTVSEPDLEYVKKLNESLDYKVGLITRDLGLASGVQSESLTG.LLYGTIFALVFVA.IPLIL.....
A0A483CSG6_9EURY/7-66                ..........k---TSGAIRMAAIDNIMADIKYKAQIMARTNKLESGIMDSGIPG.FVAGAAIALILVV.VPVML.....
A0A328PIJ7_9EURY/1-63                ...........MIKLSSKPNVRGIKNVTEDIKYRTQLIGRDGRLFAGLIATRISG.ISYGLIIAFILGLiIPLLM.....
Q6LWY9_METMP/187-248                 ...........GIPTVAEPDIESMKSLNEALDYKVGLMTRDIGLASGVQTETVTG.LMYGSVFAVALIA.VPIAL.....
A7I5S5_METB6/6-65                    ........ksa-----GPVRMVAIDNMVENVRYKSQILARTNKVESASSTNGLIA.FVAGLLVAVILIV.VPALL.....
A0A2V3JGN7_9EURY/9-67                ...........MIPELHAPNTREIERMTESIKRRALLIGRDQRTYSGIYGTRIY-.LVIGFLCALLLML.V----gt...
A0A328SP31_9EURY/1-57                .......mksi---------INNIKEVTNSIEYKTQLIGRNQRLSSGVNNTRMTG.MAIGFLLTVIIIG.LPLL-y....
A6UWH8_META3/189-250                 ...........GIPSSVEPDLEYTKKFMDTLDYKVSLITREVGLSSGTQLKSIEG.AIYGSILAVVLVG.IPVLL.....
F4BZJ1_METSG/10-71                   ...........GLPAVIEPNMPMIDAIVEDVRYKGQLLARETKLSSGVMSTVSVG.FAIGFVLAIVMML.GPFA-f....
A0A2V2N2Z2_9EURY/6-64                ........kka-----GPVRMAAIEAMVSDIKYKGQILARTNKLESGAMDSGLIG.FAIGLAVALLMVV.-PV--ll...
A0A166F2N7_9EURY/1-63                ...........MVKLSNKPNIRGIKNVSGDVKYRSQLIGREGRLFAGLISTRITG.IGLGLAIAFVLVVlIPFL-a....
Q2NI28_METST/2-55                    ........ild-----------NIGKLVESIEYKSQLIGRKERLVCGVEKTRFKG.ILIGFIITLFIVG.LPFI-s....
Q0W333_METAR/184-244                 ........ttv---AAAKPD-KEIPPLVDDVCYRAQLCARNQKLTSAVGATKVLG.FVLGAVFVIAFVL.IPVWL.....
A0A328S3B6_9EURY/1-57                .......mkdt---------LNNIKKLTESIEYKTQMIGRNQRLISGVHNTRIMG.MLIGFLITFILVG.IPI--fy...
#=GC seq_cons                        ..............hs.pPphtuIcshs-slcY+uQLIuRsp+LtSGlhuotlhG.hshGhlhAllLll.lPhl......
//
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