#=GF ID MtrF
#=GF AC PF09472.13
#=GF DE Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)
#=GF AU TIGRFAMs;
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE TIGRFAMs
#=GF GA 22.00 22.00;
#=GF TC 22.00 22.90;
#=GF NC 21.40 21.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF DR INTERPRO; IPR013347;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Many archaea have evolved energy-yielding pathways marked by
#=GF CC one-carbon biochemistry featuring novel cofactors and enzymes.
#=GF CC This domain is mostly found in MtrF, where it covers the entire
#=GF CC length of the protein. This polypeptide is one of eight subunits
#=GF CC of the N5-methyltetrahydromethanopterin: coenzyme M
#=GF CC methyltransferase complex found in methanogenic archaea. This is
#=GF CC a membrane-associated enzyme complex that uses methyl-transfer
#=GF CC reactions to drive a sodium-ion pump. MtrF itself is involved in
#=GF CC the transfer of the methyl group from
#=GF CC N5-methyltetrahydromethanopterin to coenzyme M. Subsequently,
#=GF CC methane is produced by two-electron reduction of the methyl
#=GF CC moiety in methyl-coenzyme M by another enzyme, methyl-coenzyme M
#=GF CC reductase. In some organisms this domain is found at the C
#=GF CC terminal region of what appears to be a fusion of the MtrA and
#=GF CC MtrF proteins. The function of these proteins is unknown, though
#=GF CC it is likely that they are involved in C1 metabolism.
#=GF SQ 59
#=GS MTRF_METAC/10-72 AC Q8TU04.1
#=GS H1YXH3_9EURY/9-66 AC H1YXH3.1
#=GS A0A1D3L4Q6_9EURY/182-238 AC A0A1D3L4Q6.1
#=GS D1YVZ4_METPS/6-67 AC D1YVZ4.1
#=GS D3E044_METRM/1-63 AC D3E044.1
#=GS D5E7Y8_METMS/9-71 AC D5E7Y8.1
#=GS D7EBK8_METEZ/10-72 AC D7EBK8.1
#=GS MTRF_METMA/8-70 AC P80654.4
#=GS Q12VU9_METBU/10-72 AC Q12VU9.1
#=GS MTRF_METTH/1-62 AC O27226.1
#=GS MTRF_METJA/2-63 AC Q58262.1
#=GS F7XQ95_METZD/9-71 AC F7XQ95.1
#=GS G7WPT8_METH6/27-88 AC G7WPT8.1
#=GS E1RDW8_METP4/10-66 AC E1RDW8.1
#=GS B8GE99_METPE/5-66 AC B8GE99.1
#=GS L0HIK8_METFS/6-65 AC L0HIK8.1
#=GS A0A4E0QT31_9EURY/9-71 AC A0A4E0QT31.1
#=GS A0A062VAV6_9EURY/171-231 AC A0A062VAV6.1
#=GS A0A2V3JCJ5_9EURY/185-246 AC A0A2V3JCJ5.1
#=GS I7LK65_METBM/5-66 AC I7LK65.1
#=GS A0A2V3JJD2_9EURY/43-104 AC A0A2V3JJD2.1
#=GS A0A162FL45_9EURY/1-63 AC A0A162FL45.1
#=GS A0A484F6Z2_9EURY/4-60 AC A0A484F6Z2.1
#=GS MTRF_METKA/12-73 AC Q8TVA7.1
#=GS R9SMM2_9EURY/1-63 AC R9SMM2.1
#=GS A0A1D2WBH5_9EURY/1-61 AC A0A1D2WBH5.1
#=GS A0A2U1S6S6_9EURY/1-63 AC A0A2U1S6S6.1
#=GS A2STR3_METLZ/3-60 AC A2STR3.1
#=GS A0A366M8K6_9EURY/1-63 AC A0A366M8K6.1
#=GS W9DQI1_METTI/9-71 AC W9DQI1.1
#=GS A0A498GZ13_9EURY/5-66 AC A0A498GZ13.1
#=GS A0A0X3BPR4_9EURY/5-66 AC A0A0X3BPR4.1
#=GS L0KXS0_METHD/10-72 AC L0KXS0.1
#=GS A0B8Y1_METTP/11-72 AC A0B8Y1.1
#=GS U6EEB8_9EURY/1-61 AC U6EEB8.1
#=GS A0A2Z4L8P1_9EURY/1-57 AC A0A2Z4L8P1.1
#=GS A0A1D3L4H5_9EURY/1-61 AC A0A1D3L4H5.1
#=GS F6BEA3_METIK/187-248 AC F6BEA3.1
#=GS A0A1V6N4J2_9EURY/1-63 AC A0A1V6N4J2.1
#=GS A0A166CFC4_9EURY/1-63 AC A0A166CFC4.1
#=GS Q2FRM9_METHJ/1-53 AC Q2FRM9.1
#=GS F0T8R9_METLA/1-61 AC F0T8R9.1
#=GS A0A062UZY6_9EURY/4-66 AC A0A062UZY6.1
#=GS A0A062V836_9EURY/11-72 AC A0A062V836.1
#=GS E3GZ45_METFV/2-63 AC E3GZ45.1
#=GS D7DUI1_METV3/188-249 AC D7DUI1.1
#=GS A0A483CSG6_9EURY/7-66 AC A0A483CSG6.1
#=GS A0A328PIJ7_9EURY/1-63 AC A0A328PIJ7.1
#=GS Q6LWY9_METMP/187-248 AC Q6LWY9.1
#=GS A7I5S5_METB6/6-65 AC A7I5S5.1
#=GS A0A2V3JGN7_9EURY/9-67 AC A0A2V3JGN7.1
#=GS A0A328SP31_9EURY/1-57 AC A0A328SP31.1
#=GS A6UWH8_META3/189-250 AC A6UWH8.1
#=GS F4BZJ1_METSG/10-71 AC F4BZJ1.1
#=GS A0A2V2N2Z2_9EURY/6-64 AC A0A2V2N2Z2.1
#=GS A0A166F2N7_9EURY/1-63 AC A0A166F2N7.1
#=GS Q2NI28_METST/2-55 AC Q2NI28.1
#=GS Q0W333_METAR/184-244 AC Q0W333.1
#=GS A0A328S3B6_9EURY/1-57 AC A0A328S3B6.1
MTRF_METAC/10-72 ...........GVPMVLNPQMGAIDATVESIRYRAQLIARNQKLDSGVMSTGIIG.FAAGFLFSLLMVIiLPLM-a....
H1YXH3_9EURY/9-66 .........pa------TIRMAAIKDMMEDIEFKAQVLARTNKLESSIMTSGGVG.FGVGLIISLVLVL.VPVFL.....
A0A1D3L4Q6_9EURY/182-238 ........kpv------APETALIDARIRNIQTQVKMIGANQRIFAGMYAGKVQG.LVIGLAFILTL--.-----gtill
D1YVZ4_METPS/6-67 .....avaatq------APPESAFVPMIDEICYRAQLTARNQKLSSAVGATKVLG.FLIGALFALGMVL.IPLAL.....
D3E044_METRM/1-63 ...........MVRFSNKPNTRGIRNASNNVEYRAKLLGREGRLFAGVISTRFSG.MAIGIGLALALAVvIPYL-a....
D5E7Y8_METMS/9-71 ...........GVPMVIEPKMGAIDRVVEDIRYRAQLISRSQKLDSGVSAAGIVG.FTIGFLFALIMVIiLPLLV.....
D7EBK8_METEZ/10-72 ...........GVPKVINPLMGPIESVVEKIRYRGQLIARNQKLDSGVSATGTIG.FAIGFIITMILTLvIPFLV.....
MTRF_METMA/8-70 ...........GVPMVLAPQMGAIDATVESIRYRAQLIARNQKLDSGVAATGIIG.FAAGFLFSLLMVIvLPVAV.....
Q12VU9_METBU/10-72 ...........GVPMVINPQMGAIENVVDRIRYRAQLIARNQKLDSGVNATAATG.FIVGFGFAVLMVLiLPLII.....
MTRF_METTH/1-62 ...........MIILSNKPNIRGIKRVVEDIKYRNQLIGRDGRLFAGLIATRISG.IAIGFLLAVLLVG.VPAMM.....
MTRF_METJA/2-63 ...........GVEVSNKPNVSSIQSYVEDLEYKVGLITRNRGLESGTESAGTKG.LIIGVVSAIVLMG.IPLAL.....
F7XQ95_METZD/9-71 ...........GVPTIVNPQMGTVESTVKSIEYRAQLIARNQKLDSGVGAASMVG.FSIGFVLALLFVIiLPVII.....
G7WPT8_METH6/27-88 ...........GLPTVLAPFMGPFDQITDSVLYRAQLVVRDQKLSSGVNAAMPIG.AVVGFLFAILMVL.LPVYI.....
E1RDW8_METP4/10-66 ........tii--------RTAAIEAMVADMRYKGQILARTNKLESGIMDSGIIG.FMFGLLITLALTI.VPVYL.....
B8GE99_METPE/5-66 ........gsk---AAGPIRMVAINNMVENMRYKSQILARTNKLESGIMDSGLVG.FAAGMLVALVLIV.VPALV.....
L0HIK8_METFS/6-65 .......kstg------PVRMVAIDNMVENIRYKSQILARTNKIDSAVTASGLVG.FVAGLLTALILIV.LPVLL.....
A0A4E0QT31_9EURY/9-71 ...........GVPMVINPNMGPIEAVVEDIRYRAQLIARNQKLDSGVSATGISG.FLAGFVFILLMTIiLPMV-i....
A0A062VAV6_9EURY/171-231 .........gv---TTVSPELVAIEARVRAIEGEVKDLGKVQKVMSGLTSGLFQG.FVAGFVVTLVLFA.I----mrll.
A0A2V3JCJ5_9EURY/185-246 ....iplanpa------MPFMGVIAPAVESIRYKSQMLARDYKLSMAISKNSLIG.IITGLIMALIV-S.LPF--iy...
I7LK65_METBM/5-66 ...........GIQTAGPIRMTAINRMMDSIRYKAQILARTTKLESGIMGSGILG.FAAGIIVAMLLIV.IPVLI.....
A0A2V3JJD2_9EURY/43-104 ...........GTPMVIEPFMEPFEAAVESVRRRAQLIARNQKLDSGFTAGAPLG.VAAGILFALILVL.LPLL-w....
A0A162FL45_9EURY/1-63 ...........MVKFSNKPNVRGIKSVTEDTKYKSQLIGREGRLFAGLISTRVTG.ITYGLLIAFVLVVvIPFLV.....
A0A484F6Z2_9EURY/4-60 ......qeirn-----------NLDELVSSISYRSQLISRAQKLDSGIITTRRIG.FIAGFLTAVVFVLvIPLII.....
MTRF_METKA/12-73 iigapamadtd-----------RADTYVNDVRDSSQFFGRDARLYFGLNVNRFAG.LACGMVFAGVLLV.-PL--lll..
R9SMM2_9EURY/1-63 ...........MVQISNKPNVRGLKNTADDIEYSSKLIGREGRAYAALSFTRTKG.IGIGVTIAFVLLIlLPYI-a....
A0A1D2WBH5_9EURY/1-61 .........ml---ISNKPNVRGIRKVAEDVKYRAGLIGRDQRLFAGLMATRIQG.MVMGFILAILLVG.LPIL-w....
A0A2U1S6S6_9EURY/1-63 ...........MVKISNKPNVNGINNVSEDVDYSAKLIAREGKLFAGLINTRFKG.FAYGIILALVLIViIPAI-a....
A2STR3_METLZ/3-60 ........gsi-------IRMAAIDKMVDNIRYKGQILARTNKVDSAISSSGLVG.FAAGLVLALVLIL.VPVLV.....
A0A366M8K6_9EURY/1-63 ...........MVKLSNKPNVRGIKNVSEDVKYRSQLIGREGRLFAGLISTRFTG.IGLGLAIAFVLIVvIPYL-a....
W9DQI1_METTI/9-71 ...........GVPMVITPQMGPIEAVVEDIRYRAQLIARNQKLDSGVSATGVAG.FVAGFIFAIVMVViIPM--fa...
A0A498GZ13_9EURY/5-66 ........gnk---AAGPIRMAAIDRSMNNIRYKAQIMARTNKLESGIQSGGLVG.FAAGILAAMVLIL.VPAV-f....
A0A0X3BPR4_9EURY/5-66 ...........GIQTAGPIRMTAINRMMDSIRYKAQILARTTKLESGIMGSGILG.FAIGIIVAMLLIV.IPVLI.....
L0KXS0_METHD/10-72 ...........GVPMVISPQMGPIDNVVADIRARAQLIARNQKLDSGVSATGFIG.FAAGFIFAILMAVvLPLII.....
A0B8Y1_METTP/11-72 ...........GTPAVIEPAMPLFDQIVDDIKYKAQLLARETKLSSGVIAAAPQG.FAIGFFLAVAMVL.GPFLL.....
U6EEB8_9EURY/1-61 .........ml---ISNKPNIRGIKKVAADVKYRTQLIGRDQRLFSGLIATRIYG.MAIGFILAALLIG.IPVI-w....
A0A2Z4L8P1_9EURY/1-57 ........mrk--------NIEHINDLTNTIEYKTQLIGRNERLTSGVRETRLKG.ILIGFILTCIVIL.LPIL-y....
A0A1D3L4H5_9EURY/1-61 .........ml---ISNKPNVKGIKKTVEDIRYRTQLIGRDQRLFAGLINTRVYG.MAIGFVFAMLLVG.LPVL-w....
F6BEA3_METIK/187-248 ...........GIPTVVEPDLEACQKLLEKLEYKVGLMTRDIGLASGVSSESVKG.FAIGSLLAVVLVG.IPIIL.....
A0A1V6N4J2_9EURY/1-63 ...........MVKLSNKPNVRGIKNVSEDIQYRSQLIGREGRLFAGLISTRFTG.IGLGIAIAFLLVVvIPYI-a....
A0A166CFC4_9EURY/1-63 ...........MVKFSNKPNIKGIRNTAEDTNYKAKLIGREGRLFAGLNATRITG.IAYGLILAFVLVIiIPLL-a....
Q2FRM9_METHJ/1-53 ...........---------MAAIDAMMADMKYKGQILARTNKLESGIMGAGIIG.FAIGLAFALILVVpV----ilm..
F0T8R9_METLA/1-61 .........mi---LSNKPNVRGIKSTVKDIKYRTGLIGRDQRLFAGLITTRVYG.MAVGFIFALLLVG.LPVI-y....
A0A062UZY6_9EURY/4-66 ..........k-IPLLVSPNARELNRMVSELERRVMIIGRDQRTFSGIFNLRARAyFVFGFLLALGLVF.LAMV-m....
A0A062V836_9EURY/11-72 ...........GVPMVVTPSMAAIESMIEDLRYRGQLIARNQKLESGVGSTGVIG.FIIGFFIVMMMVL.VPVL-r....
E3GZ45_METFV/2-63 ..........a-ISLSNKPNIKGVKKTTDDICYRVQLIAREGRVFSGLIQTRIPG.LIYGILLAVILIGiVA---vf...
D7DUI1_METV3/188-249 ...........GIPTVSEPDLEYVKKLNESLDYKVGLITRDLGLASGVQSESLTG.LLYGTIFALVFVA.IPLIL.....
A0A483CSG6_9EURY/7-66 ..........k---TSGAIRMAAIDNIMADIKYKAQIMARTNKLESGIMDSGIPG.FVAGAAIALILVV.VPVML.....
A0A328PIJ7_9EURY/1-63 ...........MIKLSSKPNVRGIKNVTEDIKYRTQLIGRDGRLFAGLIATRISG.ISYGLIIAFILGLiIPLLM.....
Q6LWY9_METMP/187-248 ...........GIPTVAEPDIESMKSLNEALDYKVGLMTRDIGLASGVQTETVTG.LMYGSVFAVALIA.VPIAL.....
A7I5S5_METB6/6-65 ........ksa-----GPVRMVAIDNMVENVRYKSQILARTNKVESASSTNGLIA.FVAGLLVAVILIV.VPALL.....
A0A2V3JGN7_9EURY/9-67 ...........MIPELHAPNTREIERMTESIKRRALLIGRDQRTYSGIYGTRIY-.LVIGFLCALLLML.V----gt...
A0A328SP31_9EURY/1-57 .......mksi---------INNIKEVTNSIEYKTQLIGRNQRLSSGVNNTRMTG.MAIGFLLTVIIIG.LPLL-y....
A6UWH8_META3/189-250 ...........GIPSSVEPDLEYTKKFMDTLDYKVSLITREVGLSSGTQLKSIEG.AIYGSILAVVLVG.IPVLL.....
F4BZJ1_METSG/10-71 ...........GLPAVIEPNMPMIDAIVEDVRYKGQLLARETKLSSGVMSTVSVG.FAIGFVLAIVMML.GPFA-f....
A0A2V2N2Z2_9EURY/6-64 ........kka-----GPVRMAAIEAMVSDIKYKGQILARTNKLESGAMDSGLIG.FAIGLAVALLMVV.-PV--ll...
A0A166F2N7_9EURY/1-63 ...........MVKLSNKPNIRGIKNVSGDVKYRSQLIGREGRLFAGLISTRITG.IGLGLAIAFVLVVlIPFL-a....
Q2NI28_METST/2-55 ........ild-----------NIGKLVESIEYKSQLIGRKERLVCGVEKTRFKG.ILIGFIITLFIVG.LPFI-s....
Q0W333_METAR/184-244 ........ttv---AAAKPD-KEIPPLVDDVCYRAQLCARNQKLTSAVGATKVLG.FVLGAVFVIAFVL.IPVWL.....
A0A328S3B6_9EURY/1-57 .......mkdt---------LNNIKKLTESIEYKTQMIGRNQRLISGVHNTRIMG.MLIGFLITFILVG.IPI--fy...
#=GC seq_cons ..............hs.pPphtuIcshs-slcY+uQLIuRsp+LtSGlhuotlhG.hshGhlhAllLll.lPhl......
//
