#=GF ID MutS_III
#=GF AC PF05192.21
#=GF DE MutS domain III
#=GF AU Studholme DJ;0000-0002-3010-6637
#=GF SE Prosite
#=GF GA 34.10 34.10;
#=GF TC 34.10 34.10;
#=GF NC 34.00 34.00;
#=GF BM hmmbuild --amino --handHMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF NE PF05190;
#=GF NL Q56239.3/411-502
#=GF RN [1]
#=GF RM 9722634
#=GF RT Domain organization and functional analysis of Thermus
#=GF RT thermophilus MutS protein [published erratum appears in Nucleic
#=GF RT Acids Res 1998 Oct 15;26(20):following 4789]
#=GF RA Tachiki H, Kato R, Masui R, Hasegawa K, Itakura H, Fukuyama K,
#=GF RA Kuramitsu S;
#=GF RL Nucleic Acids Res 1998;26:4153-4159.
#=GF RN [2]
#=GF RM 8036718
#=GF RT Colon cancer and DNA repair: have mismatches met their match?
#=GF RA Jiricny J;
#=GF RL Trends Genet 1994;10:164-168.
#=GF RN [3]
#=GF RM 8510668
#=GF RT The yeast gene MSH3 defines a new class of eukaryotic MutS
#=GF RT homologues.
#=GF RA New L, Liu K, Crouse GF;
#=GF RL Mol Gen Genet 1993;239:97-108.
#=GF RN [4]
#=GF RM 11048710
#=GF RT Crystal structures of mismatch repair protein MutS and its
#=GF RT complex with a substrate DNA.
#=GF RA Obmolova G, Ban C, Hsieh P, Yang W;
#=GF RL Nature 2000;407:703-710.
#=GF DR INTERPRO; IPR007696;
#=GF DR PROSITE; PDOC00388;
#=GF DC C-terminus.
#=GF DR HOMSTRAD; MutS_D2;
#=GF DR HOMSTRAD; MutS_D3;
#=GF DR HOMSTRAD; MutS_N;
#=GF DR HOMSTRAD; MutS_NC;
#=GF DR SCOP; 1ng9; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in proteins of the MutS family (DNA
#=GF CC mismatch repair proteins) and is found associated with
#=GF CC Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The
#=GF CC MutS family of proteins is named after the Salmonella
#=GF CC typhimurium MutS protein involved in mismatch repair; other
#=GF CC members of the family included the eukaryotic MSH 1,2,3, 4,5 and
#=GF CC 6 proteins. These have various roles in DNA repair and
#=GF CC recombination. Human MSH has been implicated in non-polyposis
#=GF CC colorectal carcinoma (HNPCC) and is a mismatch binding protein
#=GF CC [2]. The aligned region corresponds with domain III, which is
#=GF CC central to the structure of Thermus aquaticus MutS as
#=GF CC characterised in [4].
#=GF SQ 16151
#=GS A0A2K5NG54_CERAT/305-609 AC A0A2K5NG54.1
#=GS A0A0V1P714_9BILA/866-1151 AC A0A0V1P714.1
#=GS A0A3N4M7D0_9BACT/6-309 AC A0A3N4M7D0.1
#=GS R5DW61_9FIRM/266-557 AC R5DW61.1
#=GS H6L327_SAPGL/275-565 AC H6L327.1
#=GS A0A5J5ECS1_9PEZI/390-775 AC A0A5J5ECS1.1
#=GS E1V8H5_HALED/270-560 AC E1V8H5.1
#=GS A0A549SMX3_9RHIZ/302-600 AC A0A549SMX3.1
#=GS Q6FQA9_CANGA/300-624 AC Q6FQA9.1
#=GS A0A2A4G6I5_9FLAO/259-548 AC A0A2A4G6I5.1
#=GS A0A0J8DFN0_CLOCY/261-553 AC A0A0J8DFN0.1
#=GS F7CER9_XENTR/316-603 AC F7CER9.4
#=GS A0A1S8BIH0_9PEZI/380-729 AC A0A1S8BIH0.1
#=GS A0A1Y2GLD1_9FUNG/293-613 AC A0A1Y2GLD1.1
#=GS A0A5B8VMY1_9BACT/270-560 AC A0A5B8VMY1.1
#=GS A0A0U2Z9T8_9ALTE/288-576 AC A0A0U2Z9T8.1
#=GS A0A671SJV7_9TELE/738-1064 AC A0A671SJV7.1
#=GS U7VCV0_9FUSO/266-552 AC U7VCV0.1
#=GS G8NVP5_GRAMM/307-603 AC G8NVP5.1
#=GS A0A3Q0KQ51_SCHMA/209-497 AC A0A3Q0KQ51.1
#=GS MUTS_PROM0/364-658 AC A3PFD3.1
#=GS A0A183DTI8_9BILA/358-519 AC A0A183DTI8.1
#=GS A0A0D3LGW4_9BACT/277-566 AC A0A0D3LGW4.1
#=GS K6DDL8_9BACI/260-551 AC K6DDL8.1
#=GS A0A150G2D6_GONPE/514-880 AC A0A150G2D6.1
#=GS A0A7D8YU85_9TREE/316-623 AC A0A7D8YU85.1
#=GS MUTS_STRA5/256-547 AC Q8DWW1.1
#=GS A0A151U288_CAJCA/200-542 AC A0A151U288.1
#=GS A0A1G4MCN7_LACFM/299-622 AC A0A1G4MCN7.1
#=GS A0A1H6QTA2_9GAMM/294-598 AC A0A1H6QTA2.1
#=GS A0A2X0L6B8_9BASI/351-686 AC A0A2X0L6B8.1
#=GS A0A4Z1P058_9PEZI/161-461 AC A0A4Z1P058.1
#=GS A0A0D2DSS7_9EURO/373-736 AC A0A0D2DSS7.1
#=GS A0A667XSH8_9TELE/759-1084 AC A0A667XSH8.1
#=GS A0A421BFT9_9LACT/253-546 AC A0A421BFT9.1
#=GS F6AEG7_PSEF1/271-560 AC F6AEG7.1
#=GS A0A2T4K0W6_9RHOB/272-567 AC A0A2T4K0W6.1
#=GS R0F2C7_9BRAS/170-496 AC R0F2C7.1
#=GS F7EDR7_XENTR/716-1042 AC F7EDR7.4
#=GS A0A2K5CZE3_AOTNA/305-541 AC A0A2K5CZE3.1
#=GS A0A1H5F805_9FLAO/272-561 AC A0A1H5F805.1
#=GS R7J9C6_9BACT/142-529 AC R7J9C6.1
#=GS A0A3N2QQK4_9SPHN/265-560 AC A0A3N2QQK4.1
#=GS A0A669DGF4_ORENI/304-608 AC A0A669DGF4.1
#=GS A0A1Y5KHP1_9BACL/263-555 AC A0A1Y5KHP1.1
#=GS A0A384B2S4_BALAS/222-533 AC A0A384B2S4.1
#=GS X0D398_FUSOX/295-600 AC X0D398.1
#=GS N6XRR0_9RHOO/10-243 AC N6XRR0.1
#=GS N1JEI1_BLUG1/379-724 AC N1JEI1.1
#=GS A0A397VPD3_9GLOM/304-611 AC A0A397VPD3.1
#=GS A0A498D5J2_9FIRM/273-564 AC A0A498D5J2.1
#=GS MUTS_SHEDO/274-563 AC Q12PY3.1
#=GS A0A553HX35_9PEZI/295-599 AC A0A553HX35.1
#=GS A0A5D2SMD9_GOSMU/438-774 AC A0A5D2SMD9.1
#=GS A0A087V6H4_BALRE/93-356 AC A0A087V6H4.1
#=GS A0A369RZM2_9METZ/326-625 AC A0A369RZM2.1
#=GS A0A0W0V8U9_9GAMM/266-555 AC A0A0W0V8U9.1
#=GS A0A177VJ51_9BASI/659-956 AC A0A177VJ51.1
#=GS A0A1L9P4E0_ASPVE/199-507 AC A0A1L9P4E0.1
#=GS A0A1X7RSK3_ZYMTR/1-318 AC A0A1X7RSK3.1
#=GS A0A135L3P3_9BACI/265-556 AC A0A135L3P3.1
#=GS A0A4R2MW69_9PAST/272-559 AC A0A4R2MW69.1
#=GS L5KTC0_PTEAL/601-875 AC L5KTC0.1
#=GS A0A0C9VDD2_SPHS4/214-513 AC A0A0C9VDD2.1
#=GS A0A1M4M6P8_9FIRM/276-567 AC A0A1M4M6P8.1
#=GS J7M8B8_THEOR/397-720 AC J7M8B8.1
#=GS H3FJC5_PRIPA/1660-1969 AC H3FJC5.2
#=GS J8Q403_SACAR/255-579 AC J8Q403.1
#=GS A0A420HDZ0_9PEZI/530-831 AC A0A420HDZ0.1
#=GS A0A133Y6C8_9FIRM/282-573 AC A0A133Y6C8.1
#=GS A0A166ITL3_9AGAM/271-585 AC A0A166ITL3.1
#=GS A0A7E6DLI4_9CHIR/222-533 AC A0A7E6DLI4.1
#=GS A0A1M4YKN4_9RHOB/273-569 AC A0A1M4YKN4.1
#=GS A0A0Q3W274_9BACI/253-545 AC A0A0Q3W274.1
#=GS A0A1V6TXG5_9EURO/281-611 AC A0A1V6TXG5.1
#=GS A0A016WWK3_9BILA/255-560 AC A0A016WWK3.1
#=GS S7W6X5_SPRLO/216-572 AC S7W6X5.1
#=GS A0A6J0KGX3_RAPSA/170-499 AC A0A6J0KGX3.1
#=GS A0A183VM16_TRIRE/214-644 AC A0A183VM16.1
#=GS A0A1I7VD86_LOALO/579-911 AC A0A1I7VD86.1
#=GS A0A437BVR4_CHISP/238-484 AC A0A437BVR4.1
#=GS A0A388LVH8_CHABU/885-1205 AC A0A388LVH8.1
#=GS A0A507E1A2_9FUNG/308-619 AC A0A507E1A2.1
#=GS A0A5N5MC50_9ROSI/610-830 AC A0A5N5MC50.1
#=GS A0A0P1IF56_9RHOB/276-572 AC A0A0P1IF56.1
#=GS I9LD60_9FIRM/268-559 AC I9LD60.1
#=GS A0A1H8Z5J7_9RHIZ/283-581 AC A0A1H8Z5J7.1
#=GS G3AF40_SPAPN/312-641 AC G3AF40.1
#=GS A0A015L701_RHIIW/1-241 AC A0A015L701.1
#=GS A0A3Q7H950_SOLLC/543-755 AC A0A3Q7H950.1
#=GS A0A6B3PJD4_9BACT/271-560 AC A0A6B3PJD4.1
#=GS A0A150GM65_GONPE/617-937 AC A0A150GM65.1
#=GS A0A090D3U2_PODAN/6-361 AC A0A090D3U2.1
#=GS G2H1E9_9ENTR/273-601 AC G2H1E9.1
#=GS R5AXQ9_9BACT/269-558 AC R5AXQ9.1
#=GS A0A180FP30_9BACT/1-269 AC A0A180FP30.1
#=GS A0A341C9L1_NEOAA/525-823 AC A0A341C9L1.1
#=GS A0A1Z4S2Z0_9NOSO/307-598 AC A0A1Z4S2Z0.1
#=GS A0A4E0R6D8_FASHE/227-801 AC A0A4E0R6D8.1
#=GS A0A328U5R2_9BACL/262-554 AC A0A328U5R2.1
#=GS A0A518DS97_9BACT/276-567 AC A0A518DS97.1
#=GS A0A2U9AYD9_SCOMX/180-491 AC A0A2U9AYD9.1
#=GS A0A026WAP0_OOCBI/571-881 AC A0A026WAP0.1
#=GS MUTS_ALKEH/274-563 AC Q0A8K3.1
#=GS S8DSA7_FOMPI/410-705 AC S8DSA7.1
#=GS A0A4U7NF77_9SPIR/287-576 AC A0A4U7NF77.1
#=GS A0A6P3HC98_BISBI/738-1064 AC A0A6P3HC98.1
#=GS A0A4Y8ASH8_9FLAO/260-549 AC A0A4Y8ASH8.1
#=GS A0A1Y2J4A4_PYCCO/326-635 AC A0A1Y2J4A4.1
#=GS A0A1I1DEI5_9BURK/263-550 AC A0A1I1DEI5.1
#=GS A0A1M6NYK4_9PROT/279-581 AC A0A1M6NYK4.1
#=GS MUTS_SYNPW/376-670 AC A5GHU5.1
#=GS X7E276_9GAMM/275-564 AC X7E276.1
#=GS A0A160DWN0_9GAMM/317-605 AC A0A160DWN0.1
#=GS A0A3L9Y1W2_9RHOB/266-562 AC A0A3L9Y1W2.1
#=GS L9ZLT3_9EURY/269-561 AC L9ZLT3.1
#=GS A0A1Y2Q8N8_9SPHN/259-553 AC A0A1Y2Q8N8.1
#=GS A0A1F5L3P3_9EURO/197-505 AC A0A1F5L3P3.1
#=GS A0A250XG60_9CHLO/50-394 AC A0A250XG60.1
#=GS V4A064_LOTGI/636-959 AC V4A064.1
#=GS A0A1U8HWX2_GOSHI/299-606 AC A0A1U8HWX2.1
#=GS E4KLX5_9LACT/264-555 AC E4KLX5.1
#=GS A0A6D2KME1_9BRAS/299-606 AC A0A6D2KME1.1
#=GS A0A3N1XT50_9GAMM/278-567 AC A0A3N1XT50.1
#=GS A0A0U5GH64_9EURO/609-900 AC A0A0U5GH64.1
#=GS A0A433A2V1_9FUNG/281-480 AC A0A433A2V1.1
#=GS A0A2K8SRN8_9NOSO/307-598 AC A0A2K8SRN8.1
#=GS MUTS_FUSNN/293-582 AC Q8RFK2.1
#=GS A0A0Q7CWH7_9CAUL/284-588 AC A0A0Q7CWH7.1
#=GS A0A0F4YFI7_TALEM/203-496 AC A0A0F4YFI7.1
#=GS S6ABX0_SULDS/271-563 AC S6ABX0.1
#=GS L7VII7_THES1/271-562 AC L7VII7.1
#=GS A0A4Q7MT56_9BACT/8-211 AC A0A4Q7MT56.1
#=GS A0A4Q1BMQ3_TREME/409-772 AC A0A4Q1BMQ3.1
#=GS R7FTC4_9FIRM/272-563 AC R7FTC4.1
#=GS A0A0J0XUW4_9TREE/367-674 AC A0A0J0XUW4.1
#=GS A0A379MPH6_9BACT/282-569 AC A0A379MPH6.1
#=GS A0A4P9ZTP2_9FUNG/249-316 AC A0A4P9ZTP2.1
#=GS A0A6I8U8E9_AEDAE/305-610 AC A0A6I8U8E9.1
#=GS A0A0W0FYP2_9AGAR/495-835 AC A0A0W0FYP2.1
#=GS A0A367JTP8_RHIAZ/517-812 AC A0A367JTP8.1
#=GS A0A2T1LZL6_9CHRO/312-603 AC A0A2T1LZL6.1
#=GS A0A670YKI5_PSETE/715-1041 AC A0A670YKI5.1
#=GS A0A0D2GVC9_9EURO/376-739 AC A0A0D2GVC9.1
#=GS A0A2K1PYI1_9GAMM/335-624 AC A0A2K1PYI1.1
#=GS A0A151X4X9_9HYME/274-580 AC A0A151X4X9.1
#=GS A0A1M2VYF2_TRAPU/278-612 AC A0A1M2VYF2.1
#=GS A0A2G8RPY6_9APHY/688-982 AC A0A2G8RPY6.1
#=GS V4VL85_CITCL/170-496 AC V4VL85.1
#=GS A0A1K1LNP2_9BACL/267-559 AC A0A1K1LNP2.1
#=GS A0A2I0QWJ4_9BACI/258-549 AC A0A2I0QWJ4.1
#=GS F4S4H1_MELLP/315-629 AC F4S4H1.1
#=GS A0A4Q4XGZ2_9PEZI/259-567 AC A0A4Q4XGZ2.1
#=GS A0A1Y0MM70_9FLAO/267-556 AC A0A1Y0MM70.1
#=GS A0A329SGH8_9STRA/225-531 AC A0A329SGH8.1
#=GS A0A291BAH3_9GAMM/260-549 AC A0A291BAH3.1
#=GS A0A419MX42_9SPHN/266-561 AC A0A419MX42.1
#=GS R7BR63_9FIRM/278-569 AC R7BR63.1
#=GS W2RQ43_9EURO/635-929 AC W2RQ43.1
#=GS A0A177UB92_9BASI/311-619 AC A0A177UB92.1
#=GS A0A7E4VFR2_PANRE/6-188 AC A0A7E4VFR2.1
#=GS A0A317SBH3_9PEZI/423-714 AC A0A317SBH3.1
#=GS A0A5D0CUX5_9BACL/262-554 AC A0A5D0CUX5.1
#=GS A0A3N6MY91_9EURY/327-619 AC A0A3N6MY91.1
#=GS A0A657BAT2_9GAMM/260-549 AC A0A657BAT2.1
#=GS A0A1M6IF68_9FLAO/93-577 AC A0A1M6IF68.1
#=GS L0EWR5_LIBCB/296-594 AC L0EWR5.1
#=GS A0A166UJD5_9PEZI/196-525 AC A0A166UJD5.1
#=GS A0A2M8S4B8_9PAST/269-556 AC A0A2M8S4B8.1
#=GS D8JY61_HYPDA/318-619 AC D8JY61.1
#=GS A0A3Q7Y7X7_CICAR/189-516 AC A0A3Q7Y7X7.1
#=GS A0A371SMR2_9BACI/259-550 AC A0A371SMR2.1
#=GS A0A1Y2H878_9FUNG/407-737 AC A0A1Y2H878.1
#=GS D4GLF3_PANAM/348-635 AC D4GLF3.1
#=GS MUTS_STRMU/255-546 AC Q8DRW8.1
#=GS A0A6P5TJE2_PRUAV/47-379 AC A0A6P5TJE2.1
#=GS A0A371DJI1_9APHY/510-813 AC A0A371DJI1.1
#=GS H2YND8_CIOSA/553-878 AC H2YND8.1
#=GS A0A5N0TAX0_9GAMM/274-563 AC A0A5N0TAX0.1
#=GS A0A0L0C1K2_LUCCU/304-609 AC A0A0L0C1K2.1
#=GS A0A5Q3LDJ7_9BACT/264-555 AC A0A5Q3LDJ7.1
#=GS A0A498KAN3_MALDO/693-1009 AC A0A498KAN3.1
#=GS A0A0S4LMB9_9BACT/281-577 AC A0A0S4LMB9.1
#=GS A0A2P8ZFM7_BLAGE/139-436 AC A0A2P8ZFM7.1
#=GS A0A679HNB8_9BACT/282-577 AC A0A679HNB8.1
#=GS A0A1Q8RXG5_9PEZI/212-457 AC A0A1Q8RXG5.1
#=GS A0A2K5DPN6_AOTNA/242-553 AC A0A2K5DPN6.1
#=GS E1ZEZ8_CHLVA/496-844 AC E1ZEZ8.1
#=GS A0A1X7R868_9SACH/300-626 AC A0A1X7R868.1
#=GS A0A4Y8WNR5_9PORP/256-545 AC A0A4Y8WNR5.1
#=GS A0A1Q6A443_9SPHI/8-214 AC A0A1Q6A443.1
#=GS R7RA38_9FIRM/272-563 AC R7RA38.1
#=GS A0A2N5Y2X2_9GAMM/259-548 AC A0A2N5Y2X2.1
#=GS A0A2Z2I195_9EURY/270-565 AC A0A2Z2I195.1
#=GS A0A167DCW4_9ASCO/323-630 AC A0A167DCW4.1
#=GS V6DIL9_9BACT/61-367 AC V6DIL9.1
#=GS A0A3P1ZVN4_9BACE/271-560 AC A0A3P1ZVN4.1
#=GS R6CKP8_9BACE/272-561 AC R6CKP8.1
#=GS A0A6J3CS53_AYTFU/724-1050 AC A0A6J3CS53.1
#=GS A0A6I9IQQ9_VICPA/305-609 AC A0A6I9IQQ9.1
#=GS A0A2W7NEV3_9RHOB/276-571 AC A0A2W7NEV3.1
#=GS A0A3Q8SCB9_9BACL/262-554 AC A0A3Q8SCB9.1
#=GS A0A2I3S039_PANTR/608-934 AC A0A2I3S039.1
#=GS A0A2B7ZPM4_9EURO/295-624 AC A0A2B7ZPM4.1
#=GS A0A656HDF9_THINJ/269-558 AC A0A656HDF9.1
#=GS A0A1Q3EJ22_LENED/245-529 AC A0A1Q3EJ22.1
#=GS A0A6P6GM12_ZIZJJ/170-481 AC A0A6P6GM12.1
#=GS A0A2P1ELX4_9VIRU/323-655 AC A0A2P1ELX4.1
#=GS A0A420HEM0_9PEZI/292-596 AC A0A420HEM0.1
#=GS A0A1E4SEM2_9ASCO/599-893 AC A0A1E4SEM2.1
#=GS R5CYH8_9BACT/262-551 AC R5CYH8.1
#=GS A0A4P9ZL26_9FUNG/298-592 AC A0A4P9ZL26.1
#=GS A0A133VRA5_9EURY/363-732 AC A0A133VRA5.1
#=GS MUTS_PSEPK/269-558 AC Q88ME7.1
#=GS A0A1E4SB22_9ASCO/313-654 AC A0A1E4SB22.1
#=GS R9GNA4_9SPHI/271-560 AC R9GNA4.1
#=GS A0A4W3HR20_CALMI/416-714 AC A0A4W3HR20.1
#=GS A0A1M5UD82_9RHOB/266-562 AC A0A1M5UD82.1
#=GS A0A2R5F7C1_9PROT/278-566 AC A0A2R5F7C1.1
#=GS A0BIQ0_PARTE/524-842 AC A0BIQ0.1
#=GS A0A3P4LH92_GULGU/83-131 AC A0A3P4LH92.1
#=GS A0A0H4UY94_9COXI/276-566 AC A0A0H4UY94.1
#=GS A0A1Q9JRK1_9FIRM/272-563 AC A0A1Q9JRK1.1
#=GS E5AS57_MYCRK/310-604 AC E5AS57.1
#=GS R6JUP7_9PROT/285-585 AC R6JUP7.1
#=GS A0A0R3TEB9_RODNA/180-368 AC A0A0R3TEB9.1
#=GS B3QSH4_CHLT3/284-575 AC B3QSH4.1
#=GS A0A1U9Z6C5_9RHIZ/296-594 AC A0A1U9Z6C5.1
#=GS A0A191TJT9_9BACT/8-214 AC A0A191TJT9.1
#=GS A0A2H0ZXA1_CANAR/596-889 AC A0A2H0ZXA1.1
#=GS U1GMD1_ENDPU/295-599 AC U1GMD1.1
#=GS A0A383W701_TETOB/302-713 AC A0A383W701.1
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