GenomeNet

Database: Pfam
Entry: NEL
LinkDB: NEL
Original site: NEL 
#=GF ID   NEL
#=GF AC   PF14496.9
#=GF DE   C-terminal novel E3 ligase, LRR-interacting
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:E7K2H2_PDB:3ckd
#=GF GA   24.00 24.00;
#=GF TC   26.20 28.10;
#=GF NC   23.90 23.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19273841
#=GF RT   A family of Salmonella virulence factors functions as a distinct
#=GF RT   class of autoregulated E3 ubiquitin ligases.
#=GF RA   Quezada CM, Hicks SW, Galan JE, Stebbins CE;
#=GF RL   Proc Natl Acad Sci U S A. 2009;106:4864-4869.
#=GF DR   INTERPRO; IPR029487;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This NEL or novel E3 ligase domain is found at the C-terminus of
#=GF CC   bacterial virulence factors. Its sequence is different from
#=GF CC   those of the eukaryotic HECT and RING-finger E3 ligases, and it
#=GF CC   subverts the host ubiquitination process. At the N-terminus of
#=GF CC   the family-members there is a series of LRR repeats, and the NEL
#=GF CC   domain interacts with the most N-terminal repeat. The key
#=GF CC   residue for the ligation step is the cysteine, eg found at
#=GF CC   position 386 in UniProtKB:E7K2H2. The LRR section sequesters
#=GF CC   this active site until invasion has occurred [1].
#=GF SQ   219
#=GS A0A2N8GKQ1_9PSED/1180-1262  AC A0A2N8GKQ1.1
#=GS IPA9_SHIDS/261-471          AC Q326Z6.2
#=GS A0A2X4TFZ6_SALER/1-101      AC A0A2X4TFZ6.1
#=GS IPA3_SHIFL/287-497          AC Q83RJ4.1
#=GS IPA3_SHIFL/287-497          DR PDB; 3CVR A; 287-497;
#=GS A0A1D9IN15_9PSED/355-585    AC A0A1D9IN15.1
#=GS A0A1H1UGV5_9PSED/1771-1965  AC A0A1H1UGV5.1
#=GS A0A077ZK78_TRITR/20-230     AC A0A077ZK78.1
#=GS A0A4S5IWV6_9RHIZ/261-476    AC A0A4S5IWV6.1
#=GS A0A2R5GS35_9STRA/1265-1454  AC A0A2R5GS35.1
#=GS A0A3N4B6U4_YERPE/310-525    AC A0A3N4B6U4.1
#=GS I4N4I9_9PSED/1269-1487      AC I4N4I9.1
#=GS A0A2R5GUA5_9STRA/1736-1941  AC A0A2R5GUA5.1
#=GS Q32D09_SHIDS/324-534        AC Q32D09.1
#=GS Q89TU9_BRADU/327-548        AC Q89TU9.1
#=GS SLRP_SALTY/472-680          AC Q8ZQQ2.1
#=GS A9MG51_SALAR/390-602        AC A9MG51.1
#=GS A0A212KQ34_9CHLA/1-73       AC A0A212KQ34.1
#=GS A0A6B3P1N6_9PSED/10-256     AC A0A6B3P1N6.1
#=GS A0A1W6Z018_9BORD/1274-1490  AC A0A1W6Z018.1
#=GS J3DC55_9BURK/115-338        AC J3DC55.1
#=GS A0A2N8GNL2_9PSED/1242-1453  AC A0A2N8GNL2.1
#=GS Q327F7_SHIDS/281-491        AC Q327F7.1
#=GS A0A0H2UY03_SHIFL/303-513    AC A0A0H2UY03.1
#=GS A0A6B3NSH7_9PSED/352-571    AC A0A6B3NSH7.1
#=GS A0A0P1B904_9BASI/1-153      AC A0A0P1B904.1
#=GS C5BD28_EDWI9/401-621        AC C5BD28.1
#=GS A0A4R3Z5U2_9GAMM/343-553    AC A0A4R3Z5U2.1
#=GS F1VXA6_9BURK/210-399        AC F1VXA6.1
#=GS A0A1I4NXN3_9PSED/2055-2271  AC A0A1I4NXN3.1
#=GS A0A1W6YXX9_9BORD/8-223      AC A0A1W6YXX9.1
#=GS A0A1Y3P7R3_9PSED/1252-1476  AC A0A1Y3P7R3.1
#=GS Y4FR_SINFN/265-479          AC P55456.1
#=GS A0A0X1T1Y9_PSEAA/1363-1588  AC A0A0X1T1Y9.1
#=GS F1VW11_9BURK/23-255         AC F1VW11.1
#=GS A0A1I4XXN2_9GAMM/74-286     AC A0A1I4XXN2.1
#=GS A0A1D9IRJ0_9PSED/1358-1635  AC A0A1D9IRJ0.1
#=GS A0A1H1WBW9_9PSED/1330-1554  AC A0A1H1WBW9.1
#=GS A0A370MZ61_9BURK/158-354    AC A0A370MZ61.1
#=GS A0A2A2KFV8_9BILA/1155-1374  AC A0A2A2KFV8.1
#=GS Q89TQ6_BRADU/1-110          AC Q89TQ6.1
#=GS A0A4S5IWC8_9RHIZ/288-500    AC A0A4S5IWC8.1
#=GS A0A7K4EBZ8_PSEPU/2-216      AC A0A7K4EBZ8.1
#=GS A0A0X1T831_PSEAA/1213-1438  AC A0A0X1T831.1
#=GS A0A1V4LM61_9PSED/1390-1612  AC A0A1V4LM61.1
#=GS Q32F09_SHIDS/287-497        AC Q32F09.1
#=GS A0A1D9IIL7_9PSED/85-308     AC A0A1D9IIL7.1
#=GS Q89TL5_BRADU/304-518        AC Q89TL5.1
#=GS C3K5A0_PSEFS/374-584        AC C3K5A0.1
#=GS A0A068Z363_9GAMM/258-464    AC A0A068Z363.1
#=GS A0A4R3NND8_9RHIZ/423-580    AC A0A4R3NND8.1
#=GS A0A509D3S6_9ENTR/1-183      AC A0A509D3S6.1
#=GS A0A2X4W5S1_SALER/420-632    AC A0A2X4W5S1.1
#=GS A0A2X4TKF5_SALER/376-588    AC A0A2X4TKF5.1
#=GS IPA4_SHIFL/303-513          AC P18009.3
#=GS A0A2R5GXH3_9STRA/505-714    AC A0A2R5GXH3.1
#=GS A0A077LFZ9_9PSED/1574-1790  AC A0A077LFZ9.1
#=GS Q88K96_PSEPK/1217-1432      AC Q88K96.1
#=GS F1VWW6_9BURK/29-249         AC F1VWW6.1
#=GS A0A4U2UPI3_9GAMM/736-950    AC A0A4U2UPI3.1
#=GS G8Q505_PSEF3/1382-1615      AC G8Q505.1
#=GS A0A6B3SVH6_9BURK/442-642    AC A0A6B3SVH6.1
#=GS C3K857_PSEFS/1886-2110      AC C3K857.1
#=GS A0A2R5GA46_9STRA/224-423    AC A0A2R5GA46.1
#=GS A0A3S4I9M5_SALBN/192-401    AC A0A3S4I9M5.1
#=GS I4N376_9PSED/1385-1635      AC I4N376.1
#=GS Q88KS7_PSEPK/1197-1419      AC Q88KS7.1
#=GS A0A1B9YZ82_9BRAD/299-507    AC A0A1B9YZ82.1
#=GS A0A1H1ZY94_9PSED/1331-1558  AC A0A1H1ZY94.1
#=GS A0A1B2QYU4_9BORD/381-600    AC A0A1B2QYU4.1
#=GS A0A6S7BX55_9BURK/1-119      AC A0A6S7BX55.1
#=GS A0A109BE45_9BURK/331-544    AC A0A109BE45.1
#=GS A0A1B2R2B2_9BORD/257-490    AC A0A1B2R2B2.1
#=GS A0A1B2R2B9_9BORD/12-178     AC A0A1B2R2B9.1
#=GS A0A1G9LJJ3_9PSED/362-593    AC A0A1G9LJJ3.1
#=GS A0A0F0EGE2_9PSED/1165-1385  AC A0A0F0EGE2.1
#=GS A0A0X1T640_PSEAA/1299-1559  AC A0A0X1T640.1
#=GS A0A7D5NJP5_9GAMM/37-243     AC A0A7D5NJP5.1
#=GS A0A4Q2J257_9BURK/305-517    AC A0A4Q2J257.1
#=GS A0A4U2UPI3_9GAMM/228-442    AC A0A4U2UPI3.1
#=GS A0A1I4W0Y8_9PSED/1363-1606  AC A0A1I4W0Y8.1
#=GS A0A1I4VIL4_9PSED/1323-1538  AC A0A1I4VIL4.1
#=GS I4N2H7_9PSED/1166-1385      AC I4N2H7.1
#=GS A0A2R5GS88_9STRA/385-611    AC A0A2R5GS88.1
#=GS Q327F0_SHIDS/299-509        AC Q327F0.1
#=GS K8WYE3_9GAMM/423-639        AC K8WYE3.1
#=GS A0A1G6XNT6_9BURK/302-530    AC A0A1G6XNT6.1
#=GS A0A6G8IHT8_9BURK/496-720    AC A0A6G8IHT8.1
#=GS A0A509D2A3_9ENTR/1-50       AC A0A509D2A3.1
#=GS A0A2R5G8Y4_9STRA/707-916    AC A0A2R5G8Y4.1
#=GS A0A494Y3N0_9BURK/1869-2103  AC A0A494Y3N0.1
#=GS A0A068Z9B5_9GAMM/258-464    AC A0A068Z9B5.1
#=GS A0A5N7B8T5_9EURO/560-761    AC A0A5N7B8T5.1
#=GS I4N377_9PSED/1195-1461      AC I4N377.1
#=GS Q88K97_PSEPK/1201-1416      AC Q88K97.1
#=GS A0A1H1YJ40_9PSED/1321-1543  AC A0A1H1YJ40.1
#=GS A0A5N6DS16_ASPPA/559-756    AC A0A5N6DS16.1
#=GS A0A1H2PLS7_9BURK/308-518    AC A0A1H2PLS7.1
#=GS G2GXR7_9ENTR/1-145          AC G2GXR7.1
#=GS A0A6B3NUU2_9PSED/284-504    AC A0A6B3NUU2.1
#=GS Q886T4_PSESM/1702-1922      AC Q886T4.1
#=GS A0A1B9YZ01_9BRAD/328-544    AC A0A1B9YZ01.1
#=GS A9MNG3_SALAR/469-681        AC A9MNG3.1
#=GS A0A0Q6W239_9BURK/245-548    AC A0A0Q6W239.1
#=GS A0A6S7BGT6_9BURK/54-263     AC A0A6S7BGT6.1
#=GS A0A509C3W4_9ENTR/417-629    AC A0A509C3W4.1
#=GS A0A562BNC2_9BURK/358-578    AC A0A562BNC2.1
#=GS C3K067_PSEFS/1344-1561      AC C3K067.1
#=GS A0A1G7ASK6_9BURK/293-526    AC A0A1G7ASK6.1
#=GS A0A2X4WAS4_SALER/499-711    AC A0A2X4WAS4.1
#=GS Q8XZP6_RALSO/374-605        AC Q8XZP6.2
#=GS A9MJD9_SALAR/474-682        AC A9MJD9.1
#=GS Q327F8_SHIDS/303-513        AC Q327F8.1
#=GS A0A1X1EL27_PANCY/257-467    AC A0A1X1EL27.1
#=GS Q8XQI9_RALSO/243-450        AC Q8XQI9.2
#=GS A0A2X4TUK9_SALER/474-565    AC A0A2X4TUK9.1
#=GS A0A1I4VI94_9PSED/1330-1546  AC A0A1I4VI94.1
#=GS IPA9_SHIFL/261-471          AC Q8VSC3.2
#=GS IPA9_SHIFL/261-471          DR PDB; 3L3P A; 261-471;
#=GS A0A0X1T244_PSEAA/1340-1567  AC A0A0X1T244.1
#=GS A0A447M6G3_SALBN/31-246     AC A0A447M6G3.1
#=GS A0A509C3V7_9ENTR/20-232     AC A0A509C3V7.1
#=GS Q32F07_SHIDS/299-509        AC Q32F07.1
#=GS A0A3S4I6X3_SALBN/528-590    AC A0A3S4I6X3.1
#=GS A0A2R5GWB6_9STRA/1182-1400  AC A0A2R5GWB6.1
#=GS A0A1D9IJ01_9PSED/1331-1566  AC A0A1D9IJ01.1
#=GS A0A2R5G893_9STRA/1493-1690  AC A0A2R5G893.1
#=GS A0A380PKG6_YERPE/331-546    AC A0A380PKG6.1
#=GS F1VVU3_9BURK/3-182          AC F1VVU3.1
#=GS Q88JT1_PSEPK/1286-1536      AC Q88JT1.2
#=GS A0A0X1SZB4_PSEAA/1320-1543  AC A0A0X1SZB4.1
#=GS A0A2R5H1J0_9STRA/976-1168   AC A0A2R5H1J0.1
#=GS A0A1D9IRF3_9PSED/1855-2076  AC A0A1D9IRF3.1
#=GS A9MH39_SALAR/103-317        AC A9MH39.1
#=GS A0A1X7AL74_9GAMM/323-546    AC A0A1X7AL74.1
#=GS Q32HH8_SHIDS/145-355        AC Q32HH8.1
#=GS A0A2N8GHW3_9PSED/1420-1655  AC A0A2N8GHW3.1
#=GS A0A4Y9RES7_9BURK/476-684    AC A0A4Y9RES7.1
#=GS A0A068Z9P8_9GAMM/258-464    AC A0A068Z9P8.1
#=GS I4N0U8_9PSED/1556-1777      AC I4N0U8.1
#=GS A0A2R5GHV3_9STRA/547-753    AC A0A2R5GHV3.1
#=GS A0A2X4TT74_SALER/31-246     AC A0A2X4TT74.1
#=GS A0A068Z6R4_9GAMM/258-464    AC A0A068Z6R4.1
#=GS M5EXC9_9RHIZ/1-51           AC M5EXC9.1
#=GS A0A089YT92_9PSED/818-1040   AC A0A089YT92.1
#=GS Q87XT3_PSESM/1352-1571      AC Q87XT3.1
#=GS A0A1I4W0X1_9PSED/1367-1614  AC A0A1I4W0X1.1
#=GS Q326V4_SHIDS/28-238         AC Q326V4.1
#=GS A0A2R5FZS7_9STRA/1149-1356  AC A0A2R5FZS7.1
#=GS A0A2A2KD03_9BILA/1204-1421  AC A0A2A2KD03.1
#=GS A0A2R5GTS1_9STRA/777-976    AC A0A2R5GTS1.1
#=GS A0A1C9VHI9_9BURK/432-653    AC A0A1C9VHI9.1
#=GS A0A0H2USC0_SHIFL/292-502    AC A0A0H2USC0.1
#=GS A0A2R5GQG8_9STRA/2987-3183  AC A0A2R5GQG8.1
#=GS A0A509D260_9ENTR/20-150     AC A0A509D260.1
#=GS A0A4U8V457_9BURK/607-810    AC A0A4U8V457.1
#=GS A0A486XKL4_9BACT/647-857    AC A0A486XKL4.1
#=GS A0A4Q8QQT0_9BRAD/129-350    AC A0A4Q8QQT0.1
#=GS A0A1G7AV05_9BURK/134-364    AC A0A1G7AV05.1
#=GS A0A1V4LIB2_9PSED/1398-1637  AC A0A1V4LIB2.1
#=GS A0A1B2R567_9BORD/1275-1490  AC A0A1B2R567.1
#=GS A0A4Z0KNA4_SALET/42-250     AC A0A4Z0KNA4.1
#=GS A0A6S7B0Y4_9BURK/519-737    AC A0A6S7B0Y4.1
#=GS C5BD30_EDWI9/489-709        AC C5BD30.1
#=GS IPA7_SHIFL/281-491          AC P18014.2
#=GS IPA7_SHIFL/281-491          DR PDB; 3CKD B; 292-502;
#=GS IPA7_SHIFL/281-491          DR PDB; 3CKD A; 292-502;
#=GS IPA7_SHIFL/281-491          DR PDB; 3CKD C; 292-502;
#=GS Q32I41_SHIDS/303-513        AC Q32I41.1
#=GS A0A2X4WG93_SALER/250-464    AC A0A2X4WG93.1
#=GS A0A2R5GBH0_9STRA/537-737    AC A0A2R5GBH0.1
#=GS A0A516SFS2_9BURK/311-525    AC A0A516SFS2.1
#=GS A0A1I4TEJ3_9PSED/1387-1630  AC A0A1I4TEJ3.1
#=GS A0A068Z5Y5_9GAMM/258-464    AC A0A068Z5Y5.1
#=GS A0A2R5GF25_9STRA/555-752    AC A0A2R5GF25.1
#=GS SSPH2_SALTY/502-714         AC P0CE12.1
#=GS SSPH2_SALTY/502-714         DR PDB; 3G06 A; 502-714;
#=GS A0A6B3SUN1_9BURK/151-317    AC A0A6B3SUN1.1
#=GS A0A0H1R357_9RHIZ/330-544    AC A0A0H1R357.1
#=GS A0A068Z9E6_9GAMM/258-464    AC A0A068Z9E6.1
#=GS Q8XQ11_RALSO/97-306         AC Q8XQ11.2
#=GS A0A0X1T105_PSEAA/1382-1598  AC A0A0X1T105.1
#=GS A0A2R5G0Q0_9STRA/785-980    AC A0A2R5G0Q0.1
#=GS A9MLU8_SALAR/469-681        AC A9MLU8.1
#=GS A0A089YMI2_9PSED/1414-1655  AC A0A089YMI2.1
#=GS A0A0F0EDG3_9PSED/1215-1435  AC A0A0F0EDG3.1
#=GS A0A2Z6EUL6_9BURK/216-429    AC A0A2Z6EUL6.1
#=GS Q83R64_SHIFL/299-509        AC Q83R64.1
#=GS Q83R64_SHIFL/299-509        DR PDB; 5KH1 A; 299-509;
#=GS A0A2X4WHJ9_SALER/499-711    AC A0A2X4WHJ9.1
#=GS A0A2P9H989_PARUW/659-863    AC A0A2P9H989.1
#=GS A0A1Y6ITD6_9VIBR/359-695    AC A0A1Y6ITD6.1
#=GS E9CMD0_9GAMM/266-472        AC E9CMD0.1
#=GS A0A1G9LIR5_9PSED/319-537    AC A0A1G9LIR5.1
#=GS A0A089YQT0_9PSED/1132-1351  AC A0A089YQT0.1
#=GS A0A089YGJ0_9PSED/1223-1444  AC A0A089YGJ0.1
#=GS W0I3L7_9GAMM/491-700        AC W0I3L7.1
#=GS A0A1H1Z6R3_9PSED/1406-1640  AC A0A1H1Z6R3.1
#=GS A0A447M7P8_SALBN/1-129      AC A0A447M7P8.1
#=GS J2VA96_9BURK/168-387        AC J2VA96.1
#=GS A0A1W6Z678_9BORD/440-651    AC A0A1W6Z678.1
#=GS A0A6B3NIX2_9PSED/27-246     AC A0A6B3NIX2.1
#=GS A0A3S4E6H1_SALBN/1-57       AC A0A3S4E6H1.1
#=GS A9MH40_SALAR/285-500        AC A9MH40.1
#=GS A0A509CA53_9ENTR/287-347    AC A0A509CA53.1
#=GS A0A3S4E939_SALBN/465-680    AC A0A3S4E939.1
#=GS A0A0S1XW49_9BORD/433-691    AC A0A0S1XW49.1
#=GS A0A509CRK1_9ENTR/207-417    AC A0A509CRK1.1
#=GS A0A6B3NWG3_9PSED/1558-1778  AC A0A6B3NWG3.1
#=GS A0A7K4EB52_PSEPU/915-1133   AC A0A7K4EB52.1
#=GS A0A328ZWG9_9BURK/360-595    AC A0A328ZWG9.1
#=GS A0A509C9T5_9ENTR/1-59       AC A0A509C9T5.1
#=GS A0A0H2USG1_SHIFL/292-502    AC A0A0H2USG1.1
#=GS A0A1D9IIK3_9PSED/1814-2037  AC A0A1D9IIK3.1
#=GS A0A1V4LM60_9PSED/1175-1271  AC A0A1V4LM60.1
#=GS A0A0F0EJD9_9PSED/1404-1645  AC A0A0F0EJD9.1
#=GS A0A2G7FX06_9EURO/509-710    AC A0A2G7FX06.1
#=GS A0A109CAU6_9BURK/234-447    AC A0A109CAU6.1
#=GS Q88KC1_PSEPK/1121-1336      AC Q88KC1.1
#=GS Q88NY1_PSEPK/1155-1375      AC Q88NY1.1
#=GS A0A1V4LLZ8_9PSED/1320-1543  AC A0A1V4LLZ8.1
#=GS C5B8F6_EDWI9/369-580        AC C5B8F6.2
#=GS A0A0H2V170_SHIFL/324-534    AC A0A0H2V170.1
#=GS A0A1W6YV63_9BORD/415-639    AC A0A1W6YV63.1
#=GS L1M700_PSEPU/1558-1778      AC L1M700.1
#=GS A9MGX2_SALAR/389-601        AC A9MGX2.1
A0A2N8GKQ1_9PSED/1180-1262             ......................................WLEE.gDEGVREARQQIWQRLA....V.K...PS....G..STLLRVMDGLRLTA.........DFQVGY.........LSLQA..RVWRLLH....EA......D......T..S..E.....E.........L..-.......----------.........--.------.--.....-----------....--....-..--......-..-..----...-------------------------------...................................................................................................................--------.------.-------..-.-....-.---..---.-----.....--...--...--...-.....------.---.-........----..-...----....------...----------------wdwlrqsietrvgdaen................
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C3K857_PSEFS/1886-2110                 ......................................WLSG.vHANKHESLRFLWDALR....E.H...EG....AspDDTFRVLRDLTQSY.........DYRQGGr......irAGLTQ..RVWTLLI....AM......G......N..S..N.....H.........L..C.......ETIFLNTYA-.........AG.TCGDGA.IL.....TFSNMELMHRA....HQ....A..KS......Q..Q..GSHQ...VDKDLLVLAQGSYLIEQLDQFSEDLIARL--...................................................................................................................ETPEEPLD.AAEVTL.FFRVRLT..E.E....F.SLP..VHP.EQMLY.....AI...DE...RV...T.....EQHVQE.ARD.H........LNAL..R...STPA....LQDSIL...EREFWIEYLALSYP--ep...............................
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A0A6S7BX55_9BURK/1-119                 ...............................mtrllqi----..----------------....-.-...--....-..--------------.........------.........-----..-------....--......-......-..-..-.....-.........-..-.......----------.........--.------.--.....-----------....--....-..--......G..A..YDHR...-IDELVLRGRQVFRHTRLESIAAKKVPTLRF...................................................................................................................------AD.EIEVHL.AFQVKLN..E.V....L.QLG..SAV.RDMRF.....FD...VS...GV...T.....ESDLAG.AMT.E........VQTQ..E...-NEQ....FSAWLA...CWSPWGSMLKRH----dfek.............................
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A0A1B2R2B2_9BORD/257-490               ..............wmdqpdpelaarwteideplrhtr----..----------------....A.T...PP....T..LSFKRFLLGLTHSH.........IYRSG-.........-TTRE..EVAQWLV....QA......A......QpgR..E.....A.........L..R.......AEAFRICDEG.........SI.MCRDNA.LL.....TWNRLKMLLRK....AE....A..ME......G..Q..YADR...-LGELCHLALTTLRWETLESVAQAKIQALHKenqe...........................................................................................................rqkaGVPLIIID.PVEIML.DYQVNLA..E.A....L.HLP..LSV.KGMAF.....PD...LS...PV...T.....DLDIQQ.AKE.A........ITRI..E...-ADS....IATYLMl.dFTPFLA----------evrrqigpda.......................
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A0A1B2R2B9_9BORD/12-178                ..................................aqpl----..----------------....-.-...--....-..--------------.........------.........-----..-------....--......-......-..S..A.....Q.........L..R.......TEAFEACIEA.........AG.NCQDGA.LS.....IWNKLSMLAIE....AD....V..RE......G..R..YRGR...-LADLHSVARSIFRLKELETVASAKVEQLYAqeqq..........................................................................................................rteeeREESEIID.PLETHL.GYQLGLR..Q.A....L.DLP..IPV.TRMYY.....AD...TA...QL...T.....EEDIDQ.ALE.V........IRQA..E...-KER....FPAWLL...----------------ldfapflsevq......................
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A0A1G9LJJ3_9PSED/362-593               ......................................WLKT..---LSPEQRSKWQQLV....D.N...AElaaqV..GEFNSWLEAMRETA.........DYKSEKt.......rPHLEH..RMQSLLE....DLtr..mlE......T..S..D.....P.........I..RipkesplPTYLEIARDA.........VS.RCEDRV.LM.....GLDGMELQQVS....ER....A..SR......G..Q..YSDS...---QLIALGREMFIRDQISQIAEEKAKEL--...................................................................................................................PKGDDEEE.GVEVHL.TYLIGLR..D.R....L.GLT..LGS.QDMSF.....SS...LS...EV...G.....EEDLKR.AAQ.D........IQQQ..L..dTPGV....LRTFLA...DWEPIRQLVNQRHPAE.................................
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A0A0X1T640_PSEAA/1299-1559             ......................................WLDSsfTVAEQERKRAQWDLIA....H.E...PE....S..ETFLDAIAALRYSA.........DYRGEY........rSQLMR..RVWRMIE....AA......T......A..D..T.....Q.........L..R.......QALFDWTSD-.........LE.TCTDGF.TE.....VFSRLGGEVLL....YE....A..RQ......L..E..GDV-...REAAYLKLALGRSRLARLNDICKVETAHQDIlrasriedvraqaiaaara.............................................................................rdrsetdieeagrvaaeiaDARWPHVD.EVEIYL.AYRVDLA..E.R....L.ALP..WQP.LSMLY.....RG...AS...NV...T.....QDMTQE.AGD.Q........ILAV..E..sVPGK....QVELLL...EQPLWKDYLKT-----lpet.............................
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A0A7D5NJP5_9GAMM/37-243                .................................wlsaq----..------TAESAWAAME....K.E...DN....A..AAFSAFLSRLGETQ.........NTRENP.........-AFKV..RVTDWLT....RL......V......E..T..P.....A.........L..R.......ETTFAVAQEA.........TT.SCEDRV.TL.....AWNDMQKVALV....YD....V..EN......G..T..WDDR...-LPELMTAGCEMFRLEQLEQAARDKVKTLRL...................................................................................................................------VD.EVEVYL.AYQTGLR..D.A....L.RLT..SAG.ERMRY.....GD...VS...GV...T.....QEDLDR.ALV.Q........VRER..E...-KRA....FPTWLA...QWTPWKTALYRASP--g................................
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A0A1I4W0Y8_9PSED/1363-1606             ......................................WLEN.lSEEFRPDAEQLWNDLE....H.E...HG....S..QGFFDVIKLLRPES.........-FQTDDdealfsegrHDLTL..RIFEVMI....AI......D......Y..N..P.....Q.........F..R.......ERVFSLAGT-.........PA.NCADAG.AH.....LFNRIGVETLL....EN....I..RQ......G..R..NEQPgvsLENRLVSLARQSSRLDRVNALAHAEVRHRTAppeeg........................................................................................................glglafGSADNQVD.DVQVYL.AYQTGLK..T.R....L.DLP..WLS.EHMVY.....RN...TA...RV...T.....DEALDR.AYH.A........ILVQ..E...NGDG....LADGLL...EQTFWSEYLHDTHPA-d................................
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#=GR A0A1D9IIK3_9PSED/1814-2037  pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
A0A1V4LM60_9PSED/1175-1271             ......................................WLRE.sTNEQRQARRLIWQRLA....A.K...PQ....G..PRFLRIMDGLSLTA.........DFRVDY.........LTLQA..RVWRLLG....EA......D......A..S..E.....E.........L..W.......ARLVQDVEVA.........E-.------.--.....-----------....--....-..--......-..-..----...-------------------------------...................................................................................................................--------.------.-------..-.-....-.---..---.-----.....--...--...--...-.....------.---.-........----..-...----....------...----------------vdadnpfasftvledrarl..............
A0A0F0EJD9_9PSED/1404-1645             ......................................WLQG..---AGQAQRELWSTMF....E.S...RQ....N..AALREMLDRLTLSR.........EFQRDA.........PALRP..RVWTMLE....LA......S......Q..H..T.....P.........L..R.......EELLAIAEAF.........PV.TCGDAG.AD.....AFSDLEIAVLV....FQ....R..SA......Q..A..TASD...RGAELLALYKQLFRRHEVQRLADTLALARIVrrralldsvel............................................................................................ppldplddiddaLLRREKVD.DIEIRL.ALRQALA..G.V....L.DYP..EPS.NGMLY.....RN...MA...NL...T.....PKTIKR.VNN.A........VMAA..D...TVAN....RHAWMV...GENSWQRYLKQRYA--pq...............................
#=GR A0A0F0EJD9_9PSED/1404-1645  pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
A0A2G7FX06_9EURO/509-710               ...............................vsdwgln----..----------------....-.A...TQ....T..RNFRVFLNRLLETR.........DYRNVEs......rpRQIR-..RVDHMFE....IL......D......N..R..P.....E.........L..R.......CQFAALATSG.........TL.SCADMA.TW.....ALNNMDVAIGI....ED....A..KN......-..-..-AAD...PEAAMRALAAAHLRLSVVREHAMRISRAN--...................................................................................................................----PGRD.QAEIFL.AMETRLR..D.S....A.ALP..VTT.EDMLH.....RA...CA...AL...T.....EREYEA.ART.A.......aIQAA..S...DPQR....LDAFME...TWEPYRELQRPLE---aeh..............................
#=GR A0A2G7FX06_9EURO/509-710    pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
A0A109CAU6_9BURK/234-447               ...............................hafnelq----..-------VEPHWQKVA....G.T...QG....A..KRLCEVLDRIRTNE.........EGVDEQ.........--VQE..KVELLLQillfAM......R......G..D..A.....A.........M..L.......QSVLNAASRL.........PA.GVDS--.KI.....AVSKMYVAYME....HS....V..AV......G..E..LDAK...-PLVALQYARGVQRYTLLKAICQELLASVRV...................................................................................................................AAGYSALH.KFELCT.LFDNAMI..D.V....L.-LD..GGK.QAPSF.....EQ...DS...NP...A.....ADDLRT.AWY.E........MIQR..G...-SEG....FRDFLA...EWAPWQALMRRR----srp..............................
Q88KC1_PSEPK/1121-1336                 ......................................WLSG.fTPAQREVRLASWNRLN....Q.E...AG....A..QDLFRFFSDLRALR.........EYDAQP.........RDLQA..RVWHILE....AC......E......Q..H..A.....E.........V..R.......ASLFEQVAR-.........PR.SCSDEL.LL.....TLSELEVGALV....AK....A..GT......A..G..TGLQ...KERALVRLGRSLFRLDKVNAIAARHIADYFS...................................................................................................................------ND.PVEVYL.TYRVRLA..D.S....L.DLP..VQP.SHLSY.....ES...FS...GV...G.....REDLDA.ARS.E........VLRQ..E...TPQA....LAQALA...DRTFWQDYLQEQQAAR.................................
#=GR Q88KC1_PSEPK/1121-1336      pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
Q88NY1_PSEPK/1155-1375                 ......................................WANS.tADAERDRQQAIWTALL....E.E...PH....S..DGMFRFLADFVHGE.........DFEQHP.........GHYRS..RIWRILE....TC......E......Q..H..E.....Q.........L..R.......HQLFLEASG-.........PR.SCEDRL.LL.....LLEQMELGVLV....LR....A..VE......D..A..HGSR...MEARLLSLARGLFRLDEVDRHATLHVQRMHA...................................................................................................................-EHAPHID.EIETRL.FYRQRLA..R.P....L.GLP..IEL.DEMHY.....PS...FA...NV...T.....TSNLLR.VQD.A........VLQN..E...STDA....LIASLA...QRPFWEQYAREFHAQR.................................
#=GR Q88NY1_PSEPK/1155-1375      pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
A0A1V4LLZ8_9PSED/1320-1543             ......................................WLSG.qVGAELARKESLWSSLS....L.N...PR....S..RDFFHLLARLHDTA.........DYNLMQ.........IDLTQ..RVWDVLE....AA......G......E..D..D.....A.........L..R.......RALFQAARLG.........RV.SAQDAA.G-.....LFSDMVVRVLC....YR....A..VV......S..A..RTGNr.tLEGELVRLLRGLFRLQQVERQAMIEIGRRTQ...................................................................................................................SGPFSRAQ.ARELEL.IYRVRLA..Q.R....L.DLP..DQP.REMNF.....VR...NV...DV...S.....PEALES.AYQ.E........VAKA..E...NSDA....FLASIN...ARRFWYEYLLQTY---qde..............................
C5B8F6_EDWI9/369-580                   ......................................WLTP..ATEGEAASADRWQSIG....K.E...ED....A..AAFSSFLDQLKATQ.........HNQAA-.........-DFRM..QIAAWLT....QL......E......Q..D..D.....E.........L..R.......AKTFAMAMES.........TS.SCEDRV.TL.....AMNNMKSVQLV....HN....A..EK......G..E..FDSD...-IPGLVAVGREMFRLEKLELIAREKVKTLRV...................................................................................................................------VD.EIEVFL.GYQNKLK..K.S....L.ELT..GIT.EEMRF.....FG...VS...GI...T.....ESDLQA.AEI.Q........VKTA..E...-NSQ....FREWIL...RWEPLHNVLKRTAS--dh...............................
#=GR C5B8F6_EDWI9/369-580        pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
A0A0H2V170_SHIFL/324-534               ......................................WFPE..--ADRREVSTQWTSFS....T.E...EN....S..RAFSAFLDRLSDTV.........SARNTS.........-GFRE..QVAAWLE....KL......S......A..S..A.....E.........L..R.......QQSFAVAADA.........TE.SCEDRV.AL.....TWNNLRKTLLV....HQ....A..SE......G..L..FDND...-TGALLSLGREMFRLEILEDIARDKVRTLHF...................................................................................................................------VD.EIEVYL.AFQTMLA..E.K....L.QLS..TAV.KEMRF.....YG...VS...GV...T.....ANDLRT.AEA.M........VRSR..E...-ENE....FTDWFS...LWGPWHAVLKRTEADR.................................
#=GR A0A0H2V170_SHIFL/324-534    pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
A0A1W6YV63_9BORD/415-639               .......................eaneawiegqradpf----..----------------....-.-...-G....A..SELVKLLDRAWNLP.........ASRAN-.........DAVRD..NLRNVLR....KM......Q......QpgN..A.....G.........L..M.......MNCLQIARES.........TA.ACDDLV.LL.....TLNDLHVAALN....AD....A..EA......G..A..YDDR...-ILELMHLGEDMFNQDAVTRYVIKMLPELERrerer........................................................................................................lrqnnrPESDAHVD.QVEQIL.DMQNGLR..H.A....V.FLP..SGE.VDMQW.....AS...LS...LI...T.....WSDIEG.ARA.F........VEAE..R...NNGG....YLAYLA...DWAPLQSVMKRVAP--sl...............................
#=GR A0A1W6YV63_9BORD/415-639    pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
L1M700_PSEPU/1558-1778                 ......................................WLDR..ADAVSDARRQLWQQLE....T.G...DD....A..DDLLRLINRLRYTA.........EYRNAAt.......rPDLLE..RVWQVLT....IS......A......H..D..A.....E.........V..R.......LILNGMAEEPvrq...lrdYD.TCPDGI.RL.....EFNQMEVLVYT....GQ....A..LR......S..A..SAGQ...RGPVLYRLMRRLYRLHELDNIARQEAGAR--...................................................................................................................-------D.EAEVRL.AYRLNLA..G.Q....L.DLP..LAP.EQMLY.....AA...SA...SL...R.....PDELER.VAT.R........VRQG..E...NGQG....MLDYAA...QRDFWLSYLQETYT--sr...............................
#=GR L1M700_PSEPU/1558-1778      pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
A9MGX2_SALAR/389-601                   ......................................WLMP..AREGEPDPADRWHASG....Q.E...DN....A..AAFSLFLDRLRETE.........NFEKDA.........-GFKA..QISSWLA....LL......A......E..D..D.....V.........L..R.......AKTFAMATEA.........TS.SCQDRI.TL.....ALHHMKNVQLV....HN....A..EK......G..V..YDNN...-LPGLVSTGREMFRMEMLERIAREKARTLAF...................................................................................................................------VD.EIEVYL.AYQNKLK..K.P....L.GLT..SVT.AKMRF.....FG...VS...GV...T.....ASDLRS.AER.Q........VKAA..E...-KRE....FSEWIL...QWGPLHSVLERKEPER.................................
#=GR A9MGX2_SALAR/389-601        pAS   ..............................................................................................................................................................................................................*.....................................................................................................................................................................................................................................................................................................................................................................................
#=GC SS_cons                           ......................................TSSC..--CCCCCHHHHHHTTT....T.S...TT....H..HHHHHHHHHHHTSH.........TTHCTC.........-SHHH..HHHHHHH....HH......H......H..-..H.....H.........H..H.......HHHHHHHHHT.........TS.SSHCHH.HH.....HHHHHHHHHHH....HH....H..HH......T..T..TTT-...-HHHHHHHHHHHHHHHHHHHHHHHHHCT-SS...................................................................................................................------S-.HHHHHH.HHHHHTT..T.T....T.T-T..TS-.S-SST.....CC...GT...TS...-.....HHHHHH.HHH.H........HHHH..H...-HHH....HHHHHH...T-HHHHHHHHHHSHHH.................................
#=GC seq_cons                          ..................................................t..thWptht....p.c...tt....u..tsF.thLs+Lppot.........shppss..........shpp..pVhphLp....th......s......p..s..s.....t.........L..R.......pphFshAtcu.........sp.oCtDpl.sh.....sasphphshhs....tp....s..pp......s..h..hcsp....hstLlpluRphFRL-tl-plApcclpph...........................................................................................................................lD.-lEVhL.uapstLt..c.p....L.pLs..sts.pcMta.....hs...hu...sl...o.....tp-lpp.Apt.p........Vpst..E....spt....htpals...phs.WpphLcct.s...................................
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