GenomeNet

Database: Pfam
Entry: NLRC4_HD2
LinkDB: NLRC4_HD2
Original site: NLRC4_HD2 
#=GF ID   NLRC4_HD2
#=GF AC   PF17776.4
#=GF DE   NLRC4 helical domain HD2
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   ECOD:EUF06736
#=GF GA   33.10 33.10;
#=GF TC   33.10 33.10;
#=GF NC   33.00 33.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   27283905
#=GF RT   Crystal structure of NOD2 and its implications in human disease.
#=GF RA   Maekawa S, Ohto U, Shibata T, Miyake K, Shimizu T;
#=GF RL   Nat Commun. 2016;7:11813.
#=GF RN   [2]
#=GF RM   23765277
#=GF RT   Crystal structure of NLRC4 reveals its autoinhibition mechanism.
#=GF RA   Hu Z, Yan C, Liu P, Huang Z, Ma R, Zhang C, Wang R, Zhang Y,
#=GF RA   Martinon F, Miao D, Deng H, Wang J, Chang J, Chai J;
#=GF RL   Science. 2013;341:172-175.
#=GF DR   INTERPRO; IPR041267;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents a helical domain found in the NLRC4
#=GF CC   protein [2] and NOD2 protein [1].
#=GF SQ   14419
#=GS A0A672ILX8_SALFA/271-396    AC A0A672ILX8.1
#=GS A0A669E0N8_ORENI/725-860    AC A0A669E0N8.1
#=GS A0A669DYT6_ORENI/572-699    AC A0A669DYT6.1
#=GS A0A6Q2ZFB3_ESOLU/502-634    AC A0A6Q2ZFB3.1
#=GS A0A674DVG4_SALTR/249-373    AC A0A674DVG4.1
#=GS A0A3Q2V663_HAPBU/393-525    AC A0A3Q2V663.1
#=GS A0A672Z9N1_9TELE/510-638    AC A0A672Z9N1.1
#=GS A0A6G1QN60_9TELE/556-711    AC A0A6G1QN60.1
#=GS A0A672KUP9_SINGR/468-605    AC A0A672KUP9.1
#=GS A0A672GTR3_SALFA/435-562    AC A0A672GTR3.1
#=GS A0A665VDF8_ECHNA/581-734    AC A0A665VDF8.1
#=GS A0A7N6AUL9_ANATE/630-761    AC A0A7N6AUL9.1
#=GS A0A669EDS3_ORENI/562-705    AC A0A669EDS3.1
#=GS A0A6I9LUC7_PERMB/516-623    AC A0A6I9LUC7.1
#=GS A0A6Q2X0V5_ESOLU/562-686    AC A0A6Q2X0V5.1
#=GS A0A674CQX8_SALTR/568-701    AC A0A674CQX8.1
#=GS A0A6J3AVC3_VICPA/521-636    AC A0A6J3AVC3.1
#=GS A0A6P5DA72_BOSIN/449-564    AC A0A6P5DA72.1
#=GS A0A669C7Q4_ORENI/508-656    AC A0A669C7Q4.1
#=GS A0A669DH37_ORENI/536-666    AC A0A669DH37.1
#=GS A0A673I9V9_9TELE/422-553    AC A0A673I9V9.1
#=GS A0A0Q3VFU9_AMAAE/499-621    AC A0A0Q3VFU9.1
#=GS A0A6J0YCG0_ODOVR/587-702    AC A0A6J0YCG0.1
#=GS A0A674MLL3_TAKRU/509-636    AC A0A674MLL3.1
#=GS A0A7N6FGB1_ANATE/618-740    AC A0A7N6FGB1.1
#=GS A0A4W6BRM4_LATCA/523-673    AC A0A4W6BRM4.1
#=GS A0A0H2UKI8_DANRE/505-643    AC A0A0H2UKI8.1
#=GS A0A672G7D4_SALFA/435-568    AC A0A672G7D4.1
#=GS A0A4X2M647_VOMUR/448-567    AC A0A4X2M647.1
#=GS A0A6J2VVX9_CHACN/377-507    AC A0A6J2VVX9.1
#=GS A0A6J1XKJ4_ACIJB/481-598    AC A0A6J1XKJ4.1
#=GS A0A674CQW4_SALTR/470-603    AC A0A674CQW4.1
#=GS A0A3Q1AID8_AMPOC/444-577    AC A0A3Q1AID8.1
#=GS A0A673HQC4_9TELE/419-530    AC A0A673HQC4.1
#=GS A0A672F8H8_SALFA/484-611    AC A0A672F8H8.1
#=GS A0A673VZ17_SALTR/553-676    AC A0A673VZ17.1
#=GS A0A672JSM1_SALFA/519-643    AC A0A672JSM1.1
#=GS A0A0A0UE95_CAPHI/519-643    AC A0A0A0UE95.1
#=GS A0A3P8RJC6_AMPPE/404-521    AC A0A3P8RJC6.1
#=GS A0A6P8ENC0_CLUHA/475-606    AC A0A6P8ENC0.1
#=GS A0A673VYZ8_SALTR/476-612    AC A0A673VYZ8.1
#=GS A0A2R8Q891_DANRE/478-634    AC A0A2R8Q891.1
#=GS A0A3Q0FU30_ALLSI/521-667    AC A0A3Q0FU30.1
#=GS A0A668SMZ5_OREAU/510-658    AC A0A668SMZ5.1
#=GS A0A6P7P7S9_BETSP/639-771    AC A0A6P7P7S9.1
#=GS A0A671V0K7_SPAAU/503-634    AC A0A671V0K7.1
#=GS A0A1S3QFX3_SALSA/497-611    AC A0A1S3QFX3.1
#=GS A0A673NNV4_9TELE/402-536    AC A0A673NNV4.1
#=GS A0A671WE48_SPAAU/310-442    AC A0A671WE48.1
#=GS A0A556V5A1_BAGYA/192-317    AC A0A556V5A1.1
#=GS A0A3N0Y1B3_ANAGA/966-1099   AC A0A3N0Y1B3.1
#=GS A0A4W6CH88_LATCA/477-621    AC A0A4W6CH88.1
#=GS A0A669CWR9_ORENI/527-658    AC A0A669CWR9.1
#=GS A0A2K6L487_RHIBE/649-786    AC A0A2K6L487.1
#=GS A0A6Q2ZGV2_ESOLU/529-648    AC A0A6Q2ZGV2.1
#=GS A0A3N0YUS2_ANAGA/487-627    AC A0A3N0YUS2.1
#=GS A0A672MAJ4_SINGR/430-539    AC A0A672MAJ4.1
#=GS A0A2Y9F5H3_PHYMC/481-599    AC A0A2Y9F5H3.1
#=GS I3JN92_ORENI/699-829        AC I3JN92.2
#=GS A0A5A9PEQ6_9TELE/533-654    AC A0A5A9PEQ6.1
#=GS A0A5F4WBI4_CALJA/482-599    AC A0A5F4WBI4.1
#=GS I3JG99_ORENI/497-624        AC I3JG99.2
#=GS A0A668RNE6_OREAU/481-612    AC A0A668RNE6.1
#=GS A0A1S3QJC0_SALSA/504-631    AC A0A1S3QJC0.1
#=GS A0A665U8F6_ECHNA/520-647    AC A0A665U8F6.1
#=GS V8N8A7_OPHHA/486-601        AC V8N8A7.1
#=GS A0A3Q2VQK9_HAPBU/128-261    AC A0A3Q2VQK9.1
#=GS A0A674BGM1_SALTR/446-577    AC A0A674BGM1.1
#=GS A0A5C6MHU5_9TELE/515-649    AC A0A5C6MHU5.1
#=GS A0A6P7HFG2_9TELE/479-615    AC A0A6P7HFG2.1
#=GS A0A3Q3MZY2_9LABR/424-529    AC A0A3Q3MZY2.1
#=GS A0A6P7P8V5_BETSP/444-566    AC A0A6P7P8V5.1
#=GS A0A671WY32_SPAAU/664-791    AC A0A671WY32.1
#=GS A0A2I3SFI9_PANTR/536-653    AC A0A2I3SFI9.1
#=GS A0A673A334_9TELE/423-553    AC A0A673A334.1
#=GS E7FBD8_DANRE/640-761        AC E7FBD8.1
#=GS A0A2K5WML0_MACFA/447-570    AC A0A2K5WML0.2
#=GS A0A3Q1BVS3_AMPOC/528-656    AC A0A3Q1BVS3.1
#=GS A0A673XYS5_SALTR/651-784    AC A0A673XYS5.1
#=GS A0A287B6H0_PIG/489-624      AC A0A287B6H0.1
#=GS A0A2Y9P3R1_DELLE/517-669    AC A0A2Y9P3R1.1
#=GS V8NAB2_OPHHA/555-669        AC V8NAB2.1
#=GS A0A669DF12_ORENI/591-730    AC A0A669DF12.1
#=GS A0A1U8BTP6_MESAU/518-643    AC A0A1U8BTP6.1
#=GS F6QD53_CALJA/520-644        AC F6QD53.1
#=GS A0A665TDX6_ECHNA/565-692    AC A0A665TDX6.1
#=GS H3AM29_LATCH/309-430        AC H3AM29.1
#=GS A0A6P3S257_PTEVA/514-628    AC A0A6P3S257.1
#=GS A0A672TUI7_STRHB/480-600    AC A0A672TUI7.1
#=GS A0A2K6DYK0_MACNE/479-596    AC A0A2K6DYK0.1
#=GS A0A3Q1IP24_ANATE/628-755    AC A0A3Q1IP24.2
#=GS A0A669B9I3_ORENI/602-733    AC A0A669B9I3.1
#=GS A0A2K6DYI8_MACNE/479-596    AC A0A2K6DYI8.1
#=GS A0A669EF51_ORENI/519-647    AC A0A669EF51.1
#=GS A0A0R4IL22_DANRE/549-673    AC A0A0R4IL22.2
#=GS A0A3Q2WDX2_HAPBU/474-603    AC A0A3Q2WDX2.1
#=GS A0A6P8F265_CLUHA/415-534    AC A0A6P8F265.1
#=GS A0A669BG71_ORENI/502-608    AC A0A669BG71.1
#=GS A0A6P6H3A7_PUMCO/619-736    AC A0A6P6H3A7.1
#=GS A0A2K5J0G8_COLAP/623-733    AC A0A2K5J0G8.1
#=GS A0A3N0Y843_ANAGA/239-371    AC A0A3N0Y843.1
#=GS A0A5C6MK27_9TELE/486-599    AC A0A5C6MK27.1
#=GS A0A669EIX5_ORENI/603-736    AC A0A669EIX5.1
#=GS A0A087XZJ6_POEFO/483-614    AC A0A087XZJ6.1
#=GS A0A4W3GV81_CALMI/401-511    AC A0A4W3GV81.1
#=GS A0A6P6NC18_CARAU/559-684    AC A0A6P6NC18.1
#=GS A0A669ECY6_ORENI/519-661    AC A0A669ECY6.1
#=GS A0A1S3QIW8_SALSA/391-524    AC A0A1S3QIW8.1
#=GS A0A3P9NSR6_POERE/468-596    AC A0A3P9NSR6.1
#=GS A0A674BJZ2_SALTR/485-627    AC A0A674BJZ2.1
#=GS A0A674P9X2_TAKRU/418-560    AC A0A674P9X2.1
#=GS A0A6A5EWU1_PERFL/619-752    AC A0A6A5EWU1.1
#=GS A0A3Q3X856_MOLML/407-537    AC A0A3Q3X856.1
#=GS A0A2R8QEM0_DANRE/407-546    AC A0A2R8QEM0.1
#=GS A0A6P8U6M8_GYMAC/494-624    AC A0A6P8U6M8.1
#=GS A0A2R8QNA5_DANRE/417-541    AC A0A2R8QNA5.1
#=GS A0A3P8XXZ7_ESOLU/488-619    AC A0A3P8XXZ7.2
#=GS A0A6P7LPA6_BETSP/576-708    AC A0A6P7LPA6.1
#=GS A0A226NSE9_COLVI/520-666    AC A0A226NSE9.1
#=GS A0A671YYU8_SPAAU/560-712    AC A0A671YYU8.1
#=GS W5LP22_ASTMX/9-127          AC W5LP22.2
#=GS I3KM81_ORENI/499-632        AC I3KM81.2
#=GS A0A6P6PVX2_CARAU/641-761    AC A0A6P6PVX2.1
#=GS A0A3B5QVJ2_XIPMA/424-555    AC A0A3B5QVJ2.1
#=GS A0A5N4D2Q2_CAMDR/590-706    AC A0A5N4D2Q2.1
#=GS A0A665T3Z2_ECHNA/418-551    AC A0A665T3Z2.1
#=GS A0A2K6TBQ6_SAIBB/590-702    AC A0A2K6TBQ6.1
#=GS A0A671WL11_SPAAU/604-715    AC A0A671WL11.1
#=GS A0A667ZMR1_9TELE/415-537    AC A0A667ZMR1.1
#=GS A0A669BRK9_ORENI/432-564    AC A0A669BRK9.1
#=GS A0A665U6E0_ECHNA/640-769    AC A0A665U6E0.1
#=GS A0A671WPZ3_SPAAU/401-528    AC A0A671WPZ3.1
#=GS A0A672L9F2_SINGR/431-555    AC A0A672L9F2.1
#=GS A0A3Q3MVJ2_9TELE/468-597    AC A0A3Q3MVJ2.2
#=GS A0A674MAH4_TAKRU/181-315    AC A0A674MAH4.1
#=GS A0A673BIS8_9TELE/552-694    AC A0A673BIS8.1
#=GS A0A5C6P266_9TELE/386-528    AC A0A5C6P266.1
#=GS A0A669DJ28_ORENI/501-657    AC A0A669DJ28.1
#=GS A0A3Q3RKG0_9TELE/572-701    AC A0A3Q3RKG0.2
#=GS A0A6J2VYU0_CHACN/506-637    AC A0A6J2VYU0.1
#=GS A0A669B923_ORENI/270-394    AC A0A669B923.1
#=GS A0A5A9PEM8_9TELE/459-575    AC A0A5A9PEM8.1
#=GS A0A6P8F3D0_CLUHA/463-594    AC A0A6P8F3D0.1
#=GS A0A668RKY3_OREAU/128-261    AC A0A668RKY3.1
#=GS A0A3P9B755_9CICH/407-540    AC A0A3P9B755.1
#=GS A0A5C6MCW8_9TELE/392-519    AC A0A5C6MCW8.1
#=GS A0A2U4B4B4_TURTR/576-730    AC A0A2U4B4B4.1
#=GS A0A401Q1X1_SCYTO/295-407    AC A0A401Q1X1.1
#=GS A0A3Q0DA59_MESAU/685-795    AC A0A3Q0DA59.1
#=GS A0A674MVD5_TAKRU/482-609    AC A0A674MVD5.1
#=GS A0A6P7JY47_9TELE/518-647    AC A0A6P7JY47.1
#=GS L8YBC4_TUPCH/90-203         AC L8YBC4.1
#=GS A0A3P8TW14_AMPPE/487-616    AC A0A3P8TW14.1
#=GS A0A667YVM6_9TELE/522-649    AC A0A667YVM6.1
#=GS L5LU80_MYODS/445-559        AC L5LU80.1
#=GS A0A3P8XRC2_ESOLU/606-731    AC A0A3P8XRC2.1
#=GS A0A6P8UE57_GYMAC/548-683    AC A0A6P8UE57.1
#=GS K7AQT1_PANTR/514-629        AC K7AQT1.1
#=GS A0A6P7IFM4_9TELE/586-727    AC A0A6P7IFM4.1
#=GS A0A665X7E2_ECHNA/560-707    AC A0A665X7E2.1
#=GS A0A674AAL0_SALTR/611-735    AC A0A674AAL0.1
#=GS A0A665T2G9_ECHNA/448-581    AC A0A665T2G9.1
#=GS A0A6Q2YPN0_ESOLU/508-639    AC A0A6Q2YPN0.1
#=GS A0A673XV61_SALTR/597-748    AC A0A673XV61.1
#=GS A0A3N0Y1B4_ANAGA/520-642    AC A0A3N0Y1B4.1
#=GS A0A6Q2Y863_ESOLU/552-686    AC A0A6Q2Y863.1
#=GS A0A674AEJ7_SALTR/590-714    AC A0A674AEJ7.1
#=GS A0A6P8U413_GYMAC/595-730    AC A0A6P8U413.1
#=GS A0A673ZEP8_SALTR/517-650    AC A0A673ZEP8.1
#=GS A0A672T9N3_SINGR/427-549    AC A0A672T9N3.1
#=GS A0A3P8WKY4_CYNSE/563-686    AC A0A3P8WKY4.1
#=GS A0A3Q1BBQ4_AMPOC/481-611    AC A0A3Q1BBQ4.1
#=GS A0A1D5R1T2_MACMU/514-629    AC A0A1D5R1T2.2
#=GS A0A2U4B4Q3_TURTR/429-583    AC A0A2U4B4Q3.1
#=GS A0A672QS74_SINGR/438-560    AC A0A672QS74.1
#=GS A0A0R4ISH0_DANRE/434-570    AC A0A0R4ISH0.2
#=GS A0A6P8V485_GYMAC/631-762    AC A0A6P8V485.1
#=GS A0A6P6JQK9_CARAU/388-514    AC A0A6P6JQK9.1
#=GS A0A673GSW1_9TELE/508-654    AC A0A673GSW1.1
#=GS A0A7N6A4Z9_ANATE/630-761    AC A0A7N6A4Z9.1
#=GS A0A6J2W518_CHACN/653-781    AC A0A6J2W518.1
#=GS F1R095_DANRE/402-532        AC F1R095.2
#=GS A0A673I4Q4_9TELE/498-631    AC A0A673I4Q4.1
#=GS A0A6Q2ZAL8_ESOLU/548-679    AC A0A6Q2ZAL8.1
#=GS A0A671VRU5_SPAAU/561-699    AC A0A671VRU5.1
#=GS A0A5F4D703_CANLF/501-616    AC A0A5F4D703.1
#=GS A0A401NU56_SCYTO/618-734    AC A0A401NU56.1
#=GS A0A6J3AV74_VICPA/381-535    AC A0A6J3AV74.1
#=GS A0A671YYY3_SPAAU/447-579    AC A0A671YYY3.1
#=GS H2LRQ2_ORYLA/128-261        AC H2LRQ2.2
#=GS A0A4W5L9L7_9TELE/265-398    AC A0A4W5L9L7.1
#=GS A0A674AEJ8_SALTR/391-524    AC A0A674AEJ8.1
#=GS A0A2K6KGX3_RHIBE/452-562    AC A0A2K6KGX3.1
#=GS A0A6J3GMR6_SAPAP/604-722    AC A0A6J3GMR6.1
#=GS A0A5G2QX41_PIG/452-567      AC A0A5G2QX41.1
#=GS A0A672H3H0_SALFA/129-257    AC A0A672H3H0.1
#=GS G3S5J8_GORGO/580-698        AC G3S5J8.2
#=GS A0A1V4KC94_PATFA/521-667    AC A0A1V4KC94.1
#=GS A0A674DI17_SALTR/469-592    AC A0A674DI17.1
#=GS A0A671VG48_SPAAU/651-761    AC A0A671VG48.1
#=GS A0A6P6N7S6_CARAU/524-655    AC A0A6P6N7S6.1
#=GS A0A674ACA1_SALTR/648-781    AC A0A674ACA1.1
#=GS A0A6P6MVP6_CARAU/512-653    AC A0A6P6MVP6.1
#=GS A0A6P3VWF8_CLUHA/573-702    AC A0A6P3VWF8.1
#=GS A0A2Y9R9U2_TRIMA/414-528    AC A0A2Y9R9U2.1
#=GS A0A4W6C2V8_LATCA/521-654    AC A0A4W6C2V8.1
#=GS A0A087XFM0_POEFO/525-650    AC A0A087XFM0.2
#=GS A0A671WDD8_SPAAU/481-613    AC A0A671WDD8.1
#=GS A0A6P6P9I5_CARAU/494-621    AC A0A6P6P9I5.1
#=GS A0A6I9K3Z9_CHRAS/509-623    AC A0A6I9K3Z9.1
#=GS A0A671VGI1_SPAAU/662-788    AC A0A671VGI1.1
#=GS A0A6P3J0V4_BISBI/526-641    AC A0A6P3J0V4.1
#=GS A0A3Q4N6E3_NEOBR/478-539    AC A0A3Q4N6E3.1
#=GS A0A2R8QE06_DANRE/399-537    AC A0A2R8QE06.1
#=GS A0A096M7W5_POEFO/613-749    AC A0A096M7W5.1
#=GS A0A3Q3LL50_9TELE/517-644    AC A0A3Q3LL50.2
#=GS A0A673ZDW5_SALTR/525-650    AC A0A673ZDW5.1
#=GS A0A2K6RTM7_RHIRO/623-733    AC A0A2K6RTM7.1
#=GS A0A674DI21_SALTR/639-772    AC A0A674DI21.1
#=GS A0A669EVZ7_ORENI/545-675    AC A0A669EVZ7.1
#=GS A0A6P7KHG1_9TELE/540-684    AC A0A6P7KHG1.1
#=GS A0A5A9P6Y0_9TELE/501-627    AC A0A5A9P6Y0.1
#=GS A0A5C6NM29_9TELE/714-847    AC A0A5C6NM29.1
#=GS A0A3P9DI62_9CICH/327-459    AC A0A3P9DI62.1
#=GS A0A6P8SZU4_GYMAC/687-824    AC A0A6P8SZU4.1
#=GS A0A3Q3GG36_9LABR/427-559    AC A0A3Q3GG36.1
#=GS A0A6P8VMQ7_GYMAC/631-786    AC A0A6P8VMQ7.1
#=GS A0A673UPM4_SURSU/517-669    AC A0A673UPM4.1
#=GS A0A3P9DUA7_9CICH/550-681    AC A0A3P9DUA7.1
#=GS A0A671TXY4_SPAAU/497-627    AC A0A671TXY4.1
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